Dominic Cummings: Five of the most controversial moments from Boris Johnsons senior adviser – The Independent

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Ever since he rose to prominence as the campaign director for Vote Leave, Dominic Cummings political career has been defined by controversy.

Boris Johnsons senior adviser is seen by his supporters as an unconventional but highly effective strategist, while his opponents have labelled him arrogant and anti-democratic.

This weekend, Mr Cummings found himself in the most high-profile scandal of his career so far after reports claimed he broke lockdown rules twice by travelling from London to Durham.

Sharing the full story, not just the headlines

A strategist who has long claimed the elite in Westminster are out of touch with voters has now found himself on the wrong side of public opinion, according to a YouGov poll on Saturday which suggested 52 per cent of Britons thought he should resign.

As his position as one of the UKs most powerful political advisers is under threat, here is an overview of some of Mr Cummings most controversial moments.

As the campaign director for Vote Leave (the official pro-Brexit campaign), Mr Cummings was the man behind the widely-disputed campaign bus claim that the UK would give 350m a week to the NHS after leaving the EU.

The claim We send the EU 350m a week, lets fund our NHS instead was later proven to be untrue, but it is still considered to be one of key factors in helping the Leave side win the referendum.

In February 2017, Mr Cummings suggested the bus was one of the key reasons why the Leave campaign was successful.

Would we have won without immigration? No. Would we have won without 350m/NHS? All our research and the close result strongly suggests no, he said.

Would we have won by spending our time talking about trade and the single market? No way.

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Following the fallout from the EU referendum, MPs called for Mr Cummings to appear before a parliamentary committee investigating fake news to answer questions about his work at Vote Leave.

When he failed to appear for questioning, he was found to be in contempt of parliament and accused of showing a total disregard for the authority of the committee by Damian Collins, then-chair of the digital, culture, media and sport (DCMS) committee.

Mr Cummings claimed he was willing to speak to MPs but said he told Mr Collins to get lost after he was sent a summons.

My offer to give evidence to MPs remains open. As does my reasonable demand that ALL OF US ARE UNDER OATH TO TELL THE TRUTH. I hope they take it up but am not hopeful, he wrote on his blog.

In August last year, Mr Cummings fired Sonia Khan a special adviser to the Treasury without the permission or knowledge of then-chancellor Sajid Javid.

Ms Khan was escorted from Downing Street by a police officer after being accused of misleading Mr Cummings about contact with the former chancellor Phillip Hammond.

Dal Babu, former chief superintendent of the Metropolitan Police, called the incident a shocking abuse of armed officers and Ms Khan launched an unfair dismissal case this year.

In a meeting following the sacking, Mr Cummings is reported to have told a team of special advisers: If you dont like how I run things, theres the door.

In March, a government special adviser called Lynn Davidson was also sacked after she confronted Mr Cummings over his unkindness towards ministerial aides.

Last month, it was revealed that Mr Cummings had attended the Scientific Advisory Group for Emergencies (Sage) an independent body which has been advising the government on its response to coronavirus.

The attendance raised concerns about Sages political independence and about whether Mr Cummings had been interfering in the meetings.

Downing Street said it was factually wrong and damaging to sensible public debate to suggest that scientific advice was affected by government advisers attending the group.

However, Sir David King, a former government scientific adviser, told The Guardian: If you are giving science advice, your advice should be free of any political bias. That is just so critically important.

Earlier this year, Mr Cummings also denied a report in The Sunday Times which claimed he had set out the governments strategy as herd immunity, protect the economy and if that means some pensioners die, too bad.

In January, Mr Cummings sent out a call for misfits and weirdos to apply for jobs in government to help shake up the system.

That call is understood to have led to the hiring of Andrew Sabisky, an aide whose past comments on eugenics, race and the enforced uptake of contraception sparked outrage.

Sky News found comments under Mr Sabiskys name in 2014 which suggested there could be genetic reasons for differences between races in intelligence and suggested this could be taken into account in immigration policy.

The aide eventually resigned from his post over the backlash, citing media hysteria over his old comments which he said had become a distraction.

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Dominic Cummings: Five of the most controversial moments from Boris Johnsons senior adviser - The Independent

For cancer treatment and more, genetic-based precision medicine holds a lot of promise – Connecticut Magazine

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A month following surgery for thyroid cancer, a Hartford Hospital patients tumor grew to 10 inches. The case was presented to the hospitals tumor board, which involved 30 doctors from different specialties.

The gene mutation found to be controlling the patients tumor growth was already well-established as a driver of melanoma, the deadliest form of skin cancer, says Dr. Sope Olugbile, medical oncologist at Hartford HealthCare.Chemotherapy wouldnt work fast enough against the aggressive tumor. Tumor board members recommended a targeted therapy already treating patients with melanoma. Without that genetic information, we wouldnt have been able to come up with that therapy, he says. The treatment saved the patients life, so far. Our goal is to use more of the genetic information to drive the treatment of cancer patients.

This type of personalized care, known as precision medicine and its subset, genomic medicine, has been offered for years at world-renowned cancer-treatment hospitals such as Memorial Sloan Kettering Cancer Center in New York, Dana-Farber Cancer Institute in Boston and University of Texas MD Anderson Cancer Center in Houston. Its now the standard of care in Connecticuts Hartford HealthCare Cancer Institute, UConn Health Center in Farmington, Connecticut Childrens Medical Center in Hartford and Smilow Cancer Center at Yale New Haven Health.Cancer therapy has become precision therapy, says Dr. Roy Herbst, professor of medicinal oncology and pharmacology, and chief of medical oncology at Yale Cancer Center and Smilow Cancer Hospital.

Dr. Roy Herbst, of Yale Cancer Center and Smilow Cancer Hospital, says that precision care is often used in cancer treatment these days.

While its most commonly used with cancer patients, precision medicine is also making inroads into other areas of health care including the treatment of some cardiac patients. Its also being studied and used on a limited basis to treat those with rare diseases. In the U.S., newborns are screened with a blood test for hearing loss and heart defects. If detected and treated early, this can prevent death and disability in some cases. For some doctors and researchers, precision medicine holds the promise of effective targeted diseases and chronic conditions, and, even more revolutionary, the chance to prevent illness before it arises. The race is on to gather as much data as possible in order to increase understanding of the connection between genes and overall health; here in Connecticut, Yales Center for Genetic Health last fall launched its Generations project to collect DNA from 100,000 volunteers (see sidebar below).

Precision medicine involves the study of human genes, called the genome. The human genome contains 23 pairs of chromosomes within all human cells, and each chromosome contains hundreds to thousands of genes. Using high-level computing and mathematics, genomics researchers analyze massive amounts of DNA-sequence data to find variations or mutations that affect health, disease or response to drugs, according to an online description by The Jackson Laboratory for Genomic Medicine in Farmington.

Researchers can sequence an entire tumor to look for markers or abnormalities that can be treated with a targeted medication that attacks that mutation, unlike traditional chemotherapy that kills healthy cells along with cancer cells, says Herbst, also associate director for translational science at the Yale School of Medicine.

These days, when Yales precision medicine tumor board meets weekly, they dont focus on where the tumor began, he says. They look at what errors occurred in the DNA of the tumor, because once they know whats driving the tumor, they can treat it.For example, lung cancer is the most common cancer in the world. When a nonsmoker gets lung cancer, doctors sequence the tumors DNA to see if it contains one of eight genes known to mutate.

Each cancer cell has about 18,000 to 20,000 genes, and there are some cancers where just one of those genes is directing the growth of the cancer, Olugbile says. We call that the driver gene. The other 17,999 are just following the lead of that driver gene, he says. That means if we tag just that one gene with the medication then we can actually shut down the growth of the entire cancer.

Traditional chemotherapy can only be given for 4-6 months because of the side effects, while targeted oral medications have very few side effects and patients remain on them for an average of two years, Olugbile says.

In the past five years, genetic testing has become standard of care for some cancers specifically colon, lung and melanoma because those types of cancers tend to have genetic mutations that have been known to respond to therapy, says Sara Patterson, manager of clinical analytics and curation at Jackson Labs, which works with UConn and Yale researchers.But targeted therapy is not a cure-all, and researchers are still a long way from using precision medicine to treat all cancer patients. Even if cancers have the same genomic change and mutation, theres no guarantee they will all respond to the same therapy, she says.Overall, precision medicine is only effective at stopping the spread of cancer in an average of 20 percent of cancer patients treated, Olugbile says, with variations by cancer. Sometimes the cancer returns because the tumor changes to resist the therapy, Patterson adds.

As doctors and researchers do more genomic sequencing, the data pool will grow and so will knowledge of what medications work most effectively against various tumor types.The more information we gather, the better well know how to treat specific patients, Patterson says.

Reimbursement from insurance companies can be a challenge. If precision treatment for a particular type of cancer hasnt been approved by the insurance industry, its difficult to get reimbursed for genomic testing, says Sue Mockus, director of product innovation and strategic commercialization at Jackson Labs.Its a catch-22. Even though a patient with pancreatic cancer could benefit from a targeted therapy, unless that patient is part of a clinical trial that would pay for the genomic testing, the patient would have to pay out of pocket, the annual cost of which can run into the hundreds of thousands of dollars. If you do have a mutation identified and your physician wants to give you the medication off label, you have to fight with the insurance company, Mockus says.

Experts have suggested a value-based approach to precision medicine, reports the International Journal of Public Health. This means policy decisions about reimbursement and investment in research and development will factor in how long patients lives are prolonged and the quality of those lives, the Journal reports.

Oncologists also offer cancer patients immunotherapy, another form of personalized medicine, Patterson says. Theyre using diagnostic tests on tumors, independent of genomic sequencing, to determine if their tumor profiles make them a good immunotherapy candidate. Immunotherapy is approved for multiple tumor types, as long as they have certain markers, she says.

Former President Jimmy Carter became cancer free after receiving radiation and immunotherapy to treat the melanoma that had spread to his brain and liver. While immunotherapy can cure cancer for some, its only effective about 20 percent of the time, Olugbile says. It varies a bit by cancer, with some cancers having a higher success rate, he adds.

Through a collaboration with Memorial Sloan Kettering, Hartford HealthCares Advanced Disease Clinic was scheduled to open this spring to give patients even more options, he says. If targeted therapies and immunotherapies dont work or are not a match for patients, doctors will look for suitable clinical trials that offer potential treatments, Olugbile says.Our goal is to create awareness on two fronts, one is among the doctors. Yes, we are available to help if patients have gone through standard of care who didnt respond, he says. Its also an option for patients who want to be treated with precision medicine closer to home. The goal is to make it available so they dont have to go to New York or Boston, he says. Its right here in Hartford and hopefully at other cancer centers over time.

From Yale, Herbst leads a clinical trial through the National Cancer Institute where he and his team are trying to match the right patient to the right drug.Every tumor is getting sequenced. Thats accelerating the field. The sequencing techniques have gotten cheaper and faster, so we can analyze them at the point of care, Herbst says. This is why clinical trials are so important. Whats a clinical trial today is standard of care tomorrow.

In a study published in the journal Science Translational Medicine, a multi-institutional research team including a Connecticut doctor developed an advanced method to analyze existing data from thousands of clinical trials, comparing which genes FDA-approved drugs work against to the genes active in pediatric brain tumor patients. This sped up the lengthy process of developing cancer drugs.

Dr. Ching Lau, head of the oncology-hematology division at Connecticut Childrens Medical Center and the pediatric oncology-hematology department at UConn School of Medicine, is accessing the World Community Grid, an IBM-funded program that allows researchers worldwide to perform tens of thousands of virtual experiments. Instead of screening thousands and thousands of compounds to try to find a potential drug, we found we could use genomics data already available and do a more systems-approach analysis to figure out the predominant pathways driving the tumor cells, Lau, professor at The Jackson Laboratory, says in an email. Then we asked if there were any existing FDA-approved drugs that could potentially modulate those pathways.

The researchers identified eight drugs that could potentially fight medulloblastoma (MB) tumors, the most common malignant brain tumor in children. One of the drugs showed an increased survival rate in mice with MB tumors, and a clinical trial is being pursued.

Personalized medicineand heart disease

Precision medicines applications have expanded beyond cancer care. At first, much heart disease research relied on a genetic analysis of whether someone was predisposed to a disease. Thanks to a growing database of patient information that is shared worldwide, researchers can mine huge data sets with hundreds of thousands of cases for patterns and abnormalities that lead to discoveries, says Beth Taylor, associate professor of kinesiology at UConn and director of exercise physiology research in cardiology at Hartford Hospital. Researchers and clinicians know that about half the people who have heart attacks dont have the typical risk factors such as high blood pressure, obesity and diabetes. To determine why physically active people with healthy diets have heart attacks, researchers are using precision medicine to comb through large studies to find small predictors, Taylor says. Often the influence of any one factor is hard to detect unless you have a big sample size, she says.

The National Institutes of Health requires grant recipients to share their data to a national registry so that researchers have access to big data, she says. (Personal information such as date of birth, name and address are removed from files used for research studies.)

When we first began to really measure genetic variations, it was believed that was going to be the big hope in treatment, Taylor says. But genes are complex and environmental factors modify genetics for multiple generations.

For the first time ever, weve got wide-scale computing ability to analyze huge data points. This can better allow us to predict disease progression and optimize treatment, she says. Many of us would say that this concept of big data is as or more important than genetic risk. Genetic risks are not the whole picture.

For the first time ever, weve got wide-scale computing ability to analyze huge data points. This can better allow us to predict disease progression and optimize treatment.

Progress with diabetes

Precision medicine is not widely used in the treatment ofdiabetesin the U.S., except when it comes to a rare form of diabetes called neonatal diabetes mellitus. While type 1 and type 2 diabetes are controlled by two or more genesand additional genetic factors,neonatal diabetes mellitus involves a single gene and develops in babies under 6 months old.

Through genetic testing of babies with elevated blood sugar levels,researchers learnedthat about half the patients have gene mutations that respond well to a pill used to treat type 2 diabetes and they dont need to be on insulin for the rest of their lives like type 1 diabetics, says Karel Erion,director of research stewardship and communications for the American Diabetes Association.

When infants show signs of type 1 diabetes at Yale New Haven Childrens Hospital or Connecticut Childrens Medical Center, they are automatically tested for neonatal diabetes, hospital doctors say.

An example of precision medicine as a predictor of disease is the TrialNet database, which uses genetic testing to determine whether the relatives of those with type 1 diabetes have two or more of the five diabetes-related autoantibodies (proteins produced by the immune system directed against the persons own proteins) linked to increased risk of developing type 1 diabetes. Type 1 diabetics must take insulin for the rest of their lives to survive, and theres no known way to prevent the autoimmune disease. Type 1 diabetes, formerly called juvenile diabetes, typically strikes children and adolescents, causing the pancreas to stop producing insulin, a hormone needed to process sugar, or glucose, from food. Type 2 diabetes was formerly known as adult-onset diabetes, but the disorder is being seen in more children, thought to be the result of a rise in childhood obesity. Screening identifies the early stages of the disease years before any symptoms appear, according to the TrialNet website.

In a study published in the New England Journal of Medicine, researchers from the TrialNet Study Group, led by Yale Universitys Dr. Kevan Herold, found that an experimental medication delayed the onset of type 1 diabetes in high-risk participants by two years compared to the control group. The disease was diagnosed in 43 percent of the participants who received the medication, teplizumab, and 72 percent of those who received the placebo.

Alzheimers disease and dementia

Only 1 to 3 percent of the 5 million people living with Alzheimers disease have a genetic mutation that leads to whats called genetic or familial Alzheimers. But one in three older adults will eventually develop some form of dementia, says Rebecca Edelmayer, the Alzheimers Association director of scientific engagement.

Like other diseases that strike large segments of the population, researchers rely on big data to learn about Alzheimers and which genes play a role in who gets it.Researchers have learned that there are several risk factors that contribute to dementia, she says. Specifically, the presence of heart disease, high blood pressure, diabetes, social and cognitive isolation, poor nutrition and the level of education, can contribute to cognitive decline, she says.

Scientists from around the world share research data and draw from data in the Global Alzheimers Association Interactive Network, she says.The field has made some dramatic advances in understanding of how genetics play a role and how other underlying diseases play a role, Edelmayer says. We need to give doctors evidence-based recommendations.

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For cancer treatment and more, genetic-based precision medicine holds a lot of promise - Connecticut Magazine

Drug factories: GMOs and gene editing are poised to transform medicine. Here’s how. – Genetic Literacy Project

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No one likes getting a shot at the doctors office. As kids, we werent used to having a sharp needle prick our skin, let alone by someone doing it on purpose. An estimated 10% of the population is affected by trypanophobia the fear of needles or injections. Luckily, for most, shots are an infrequent occurrence often limited to vaccinations. However, for millions of others, injections are a more frequent fact of life required in dealing with disease. The need for these injections and their associated doctor visits mean the physical discomfort of the treatment is often compounded by a financial burden.

Fortunately, plant biotechnology is poised to drastically improve how we consume medication. Using the modern tools of genetic engineering, researchers are developing plant-based drugs that are cheaper, easier to take and even more effective than their existing counterparts.

Cant more medicines be reformulated for oral delivery?

While many diseases can be treated with orally administered medications, other drugs such as biologics or biopharmaceuticals, medicines derived from living organisms, must be delivered using other strategies. Conventional drugs like aspirin are chemically synthesized and can survive digestion, whereas biologics like hormones, antibodies, enzymes, and other complex organic molecules are vulnerable to degradation by enzymes in our saliva and stomach, as well as environmental conditions like pH and heat. This makes biologics in pill form unlikely to survive the harsh environment of the digestive tract.

Pricey biologics

In addition to the unpleasant nature of biologic injections is their associated costs. Biologics are made by taking the DNA blueprint for the molecule and expressing it in bacterial, yeast, or mammalian cells. Once these cells, typically grown in large vats filled with nutrient media, produce the molecule of interest, it must be isolated and purified. Each step of this process must be exact and carefully maintained as small variations may change the structure and identity of the drug, potentially altering its behavior. This complex manufacturing process in addition to more rigorous FDA regulations mean higher drug prices for consumers. Combined with the price of doctor visits to get these frequent injections or infusions, the annual cost of some biologics can reach hundreds of thousands of dollars.

There are more than 200 FDA-approved biologic drugs. While less than two percent of people in the US rely on biologics, they make up 40 percent of prescription drug spending. Identifying a better way to produce and administer biologics has the potential to ease the physical and financial burden associated with these drugs. For this reason, researchers are turning to the original inspiration for medications: plants.

Turning plants into pharmaceutical factories

Evidence for plant use in medicine dates back all the way to the Palaeolithic Age. But instead of trying to find new plants that produce medically relevant compounds, researchers are turning to genetic engineering to express the same biologics currently grown in bacterial, yeast, or mammalian cells.

Producing biologics in plants has a number of advantages. Plants are potentially less costly to grow, requiring inexpensive fertilizers instead of specialized cell culture growth media. Plants can also be grown in fields or greenhouses without requiring sterile environments, meaning that scaling up production would just require more growing area as opposed to additional expensive bioreactors. An added benefit is that plants do not serve as hosts for human pathogens, reducing the likelihood of harm from contaminants that bacterial or mammalian cells may house.

Once the drug-producing plants are grown, the medically relevant proteins may be extracted and purified. But plants allow for this platform to be taken one step further: by turning the biologic- expressing plants into a freeze-dried (lyophilized) powder and placing it into a capsule, the drugs can be delivered orally. Plant cell walls contain cellulose which cannot be digested by enzymes in the stomach but can be broken down by the commensal bacteria living in our intestines. Plant-encapsulated drugs are then released in the blood-rich absorptive environment of the small intestine, where they become bioavailable and distributed to target tissues. By producing these drugs in a lyophilized form, manufacturers can cut out the expensive purification process and the need for cold transport and storage.

Current research efforts

Theres been some reported success using this method, including a March 2020 paper from a team at the University of Pennsylvania describing a lettuce expressing a novel human insulin-like growth factor-1 (IGF-1). IGF-1 helps promote skeletal muscle and bone development. For this reason, IGF-1 injections have been used in the treatment of several muscle disorders and have the potential for therapeutic benefit in healing bone fractures.

To study if plant-grown IGF-1 might be an effective replacement for traditional IGF injections, the team modified human IGF-1 to allow for uptake through the gut. They found that their modified version not only stimulated proliferation of several cell types better than current commercial IGF-1, but also that the plant-encapsulated drug could be administered orally to mice and would effectively be delivered to blood serum. The team also found that this administration of the drug significantly increased bone density in diabetic mice as compared to a control group.

In addition to medication production, companies are also looking to utilize some of the benefits of plant-based production for vaccines. Medicago, a Canada-based company seeking approval for their plant-produced flu vaccine, has announced that using this same technology, they have produced a candidate vaccine for COVID-19 in twenty days. By growing the protein for the vaccine in plants, as opposed to using eggs to propagate the virus, Medicago has been able to cut the cost and time required to produce a new vaccine. The vaccine is now awaiting clinical testing and FDA approval.

Similar to the work on orally administered IGF-1, theres also a lot of interest in making edible vaccines. In the future, you may no longer need to go to a clinic to get a seasonal flu vaccine, but instead eat a salad made with vaccine-containing lettuce or tomatoes. This could potentially reduce patient discomfort and increase vaccine compliance, minimizing everybodys risk of contracting infectious diseases. Edible vaccines would also help expand access to immunization in parts of the world were delivering vaccines may be difficult.

Plant-produced pharmaceuticals have the potential to improve the quality of life for millions of people by reducing the physical and financial burden of relying on biologics to stay healthy. There may even come a day when getting a shot at the doctors office is a thing of the past replaced by a quick trip to the grocery store.

Tautvydas Shuipys is a PhD candidate in the Genetics and Genomics Graduate Program at the University of Florida. Follow him on Twitter @tshuipys

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Drug factories: GMOs and gene editing are poised to transform medicine. Here's how. - Genetic Literacy Project

How to know your risk factors for hypertension and whether high blood pressure is genetic – Insider – INSIDER

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Hypertension is the medical term for high blood pressure. It can cause serious health problems, like heart disease or stroke, if left untreated.

There are many risk factors that make it more likely for someone to develop hypertension. These include genetic factors, age, race, medical conditions, and unhealthy lifestyle choices.

Here's what you need to know about what increases the risk of high blood pressure.

Overall, one or more of these factors are most likely to cause high blood pressure:

One of the biggest culprits is smoking, which can double or triple the risk of developing hypertension. That's because smoking damages blood vessels and can reduce blood flow to the heart.

But these factors won't always cause hypertension alone genetics and medical conditions can also increase your risk.

"I would say the simplest answer to this is, yes, there is a genetic component," says Joshua Shatzkes, MD, a cardiologist at Mt. Sinai Hospital.

If your parents have hypertension, you are at an increased risk for high blood pressure.

A 2018 study involving over a million people identified 500 genes that influence blood pressure. Some of these genes influence the cells lining blood vessels, causing them to be abnormally constricted and raise blood pressure.

Other genes can cause high cholesterol, especially in a condition known as hypercholesterolemia, which can also increase blood pressure.

In addition, genetic factors often combine with other adverse lifestyle choices, which can further increase the risk of hypertension.

For example, when you're growing up, if your family eats an unhealthy diet high in sodium, creates a high stress environment, smokes too many cigarettes, and doesn't exercise often, then you're more likely to inherit those behaviors and more likely to develop hypertension.

While there's no universal way to describe obesity, it's often considered a condition where someone has a high body mass index (BMI). A BMI over 40 can double or triple your likelihood of developing obesity-related illnesses.

"When someone is obese, it simply takes more work for the heart to pump blood throughout the whole body," says Christopher Granger, MD, a cardiologist at Duke Health. "And when it has to pump blood throughout the whole body, it has to generate a higher kind of pressure to do so."

In fact, a study from 2015 suggests that excess body fat accounts for 65% to 75% of hypertension cases. Moreover, a 2017 study found that childhood obesity increased the rate of developing adult hypertension by 65%.

Diabetes is a condition where your body doesn't react to high blood sugar properly, which may cause it to be too high or too low longer than normal. Insulin is the hormone designed to take glucose (sugar) from the blood to the cells, but if there's not enough insulin, glucose stays in the blood, elevating blood sugar levels.

Over time, high blood sugar can cause plaque to build up in your blood vessels, which narrows the vessel and increases blood pressure.

Granger explains that high blood sugar can cause the arteries to stiffen because it can increase the production of free radicals tiny particles that damage cells and reduce nitrous oxide, a chemical that dilates blood vessels.

As a result, 30% of people with type 1 diabetes develop hypertension. Those with type 2 diabetes are 2.5 times more likely to develop hypertension and 50% to 80% will develop hypertension. However, diabetics who carefully control their blood sugar levels can effectively decrease the risk of developing hypertension.

The American Heart Association has found that over 40% of non-Hispanic African-Americans have high blood pressure, and that it can develop earlier in their lives and become more severe.

Overall, black Americans are twice as likely to develop hypertension by the age of 55 compared to white Americans. Systemic issues could explain this increase in blood pressure.

There's an association between racism and higher blood pressure in African-American men, according to the CDC. Black Americans are also exposed to more factors that can increase chronic stress such as discrimination and lower socioeconomic status which may contribute to high blood pressure.

Older people are more likely to develop hypertension because the arteries stiffen as we age. This process is called atherosclerosis, and it describes plaque build-up in blood vessels.

According to Granger, young people's arteries are able to expand and more effectively accommodate the pulse of blood flow.

Overall, your lifetime risk for developing hypertension is 90%, according to Johns Hopkins Medicine. Even if you have heart-healthy habits, you'll still most likely develop hypertension, according to the National Institute on Aging.

However, certain lifestyle changes, such as exercising every day, sleeping adequately, and avoiding smoking, can lower the risk of developing high blood pressure.

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How to know your risk factors for hypertension and whether high blood pressure is genetic - Insider - INSIDER

Israeli Lab: Drugs For Gaucher Disease May Work Against Coronavirus, Other Viral Infections | Health News – NoCamels – Israeli Innovation News

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Israeli scientists at the Israel Institute for Biological Research (IIBR) have found that a combination of two existing antiviral drugs for Gaucher disease appears to inhibit the growth of SARS CoV-2, the virus that leads to COVID-19 and may work against other viral infections, including a common flu strain.

The IIBR is a governmental research center specializing in biology, chemistry and environmental sciences that falls under the jurisdiction of the Prime Ministers Office. During the pandemic, announcements have been issued by the Defense Ministry.

According to a press announcement on Tuesday, scientists at the secretive bio-defense lab tested an analog of the FDA-approved drug Cerdelga, and an analog of a second drug, Venglustat, currently in advanced trials. They found that, in combination, the drugs led to a significant reduction in the replication capacity of the coronavirus and to the destruction of the infected cells.

The two drugs are used to treat Gaucher disease, an inherited genetic condition most common in people of Ashkenazi Jewish descent that leads to the buildup of fatty substances in certain organs, particularly the spleen and liver, and can affect their function. The disease can also lead to skeletal abnormalities and blood disorders, In rare cases, Gaucher disease can also lead to brain inflammation, according to the Mayo Clinic. The disease is unrelated to COVID-19.

The Israeli researchers tested the drugs on mouse models using four different RNA viruses: Neuroinvasive Sindbis virus (SVNI), an infection transmitted via mosquitos that can lead to years of debilitating musculoskeletal symptoms; West Nile virus (WNV), also a mosquito-borne disease that can cause neurological disease and is potentially fatal; Influenza A virus, a strain of the flu; and SARS-CoV-2.

The researchers found that the two drugs were effective in all four cases. They work by inhibiting glucosylceramide synthase *GCS), an enzyme involved in the production of glucocerebroside, a lipid that accumulates in the tissues of patients affected with Gaucher disease. In the lab setting, they inhibited the replication of the viruses, and in the case of mice infected with SVNI, increased their survival rate.

In the case of COVID-19, the drugs have an antiviral effect on the SARS-CoV-2 clinical isolate in vitro, with a single dose able to significantly inhibit viral replication within 2448 h.

The two drugs are currently being tested for their effectiveness in treating animals infected with the coronavirus.

The study, published in bioRxiv, has not yet been peer-reviewed. The authors are all from the IIBRs Department of Infectious Diseases

The data suggests that GCS inhibitors can potentially serve as a broad-spectrum antiviral therapy and should be further examined in preclinical and clinical trial, the scientists wrote, adding that repurposing approved drugs can lead to significantly reduced timelines and required investment in making treatment available.

Treatment of a new disease such as COVID-19 using an existing, approved drug may serve as an effective short-term solution considering that one of the major challenges in addressing such a pandemic is the length of time it takes for both the research and approval phases of new drugs, the Defense Ministry wrote in the announcement.

The lab has been conducting various research into COVID-19 for several months, including studies on possible treatment and a vaccine. Israeli Prime Minister Benjamin Netanyahu tapped the institute in early February to begin development on inoculation. In early April, the center reported significant progressand trials on animals.

The institute has also been involved in plasma collection from Israelis who have recovered from COVID-19 to research antibodies, proteins made by the immune system that can attack the virus.

Earlier this month, the IIBR said it completed a groundbreaking scientific development toward a potential treatment based on an antibody that neutralizes SARS-CoV2. The development had three key parameters, according to the IIBR: first, the antibody is monoclonal (lab-made identical immune cells that are all clones of a unique parent cell), and contains a low proportion of harmful proteins; second, the institute has demonstrated the ability of the antibody to neutralize the coronavirus; and third, the antibody was specifically tested on SARS CoV-2.

The Ness Ziona-based institute said it is now pursuing a patent for its development after which it will approach international manufacturers.

A number of Israeli scientific teams and over 100 groups worldwide are currently working to develop a vaccine or a treatment for COVID-19.

At least 10 candidate vaccines are in clinical evaluation, including those of Massachusetts-based company Moderna which was the first to develop an experimental vaccine that went into trial quickly, and California-based biotech firm Gilead Sciences, which is evaluating the safety and efficacy of its novel antiviral drug Remdesivir, developed originally for Ebola, in adults diagnosed with COVID-19.

Last month, Israeli scientists at theMigal Galilee Research Institute formed a new company, MigVax, to further adapt a vaccine they developed for a deadly coronavirus affecting poultry for human use. The scientists had been working for four years to develop a vaccine for IBV (Infectious Bronchitis Virus) which affects the respiratory tract, gut, kidney and reproductive systems of domestic fowl.

Also in April, an Israeli scientist wasawarded a US patent for his innovative vaccine design for the corona family of viruses and indicated that he was on track to develop a vaccine for SARS CoV2.

Meanwhile, two Israeli bio-medical companies nabbed FDA approval for separate trials in the US with their respective solutions for COVID-19 as part of a compassionate use program, a treatment option that allows for the use of not-yet-authorized medicine for severely ill patients.

BothRedHill BioPharma, a publicly-traded specialty biopharmaceutical company, andPluristem Therapeutics, also a public company that specializes in placental cell therapy, were given the green light for their imminent separate studies with the investigational drug, opaganib, and the placental cell therapy PLX, respectively.

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Israeli Lab: Drugs For Gaucher Disease May Work Against Coronavirus, Other Viral Infections | Health News - NoCamels - Israeli Innovation News

Venture capital found its footing in biotech. Then came the virus. – BioPharma Dive

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Amir Nashat has spent nearly two decades building biotechnology companies. The first he worked on, Alnylam Pharmaceuticals, pioneered a new way to make genetic medicine. He's since helped advise and nurture at least 16 others, several of which were acquired for hundreds of millions of dollars.

Despite this track record, Nashat, a partner at the venture firm Polaris Partners, says most of his career in venture capital took place under "really crappy circumstances" that made it challenging to invest in young drug companies. Only in the last five or so years did things really start to change.

It was during this period that public markets came to love young biotechs, buying into record stock offerings. Large drugmakers, starved for innovation, also turned to them for their next drugs. This created a "hyper-compressed, hyper-intense environment," according to Nashat, where venture firms had much clearer and quicker paths to earn returns on their investments. For venture capitalists, there had never been a better time to invest in drug startups and, coming into 2020, many expected another big year.

Their predictions were quickly upended by the spread of the new coronavirus, which has infected millions and brought the global economy to a halt. In the past, economic downturns shaped how venture firms fund and incubate drug companies. Now, a pandemic threatens to do the same.

BioPharma Dive spoke with half a dozen venture capitalists who grow drug companies, as well as legal and financial advisors who work with healthcare venture firms. Almost all said the spread of the new coronavirus is affecting to some degree how they manage existing investments or think about new ones.

"It used to be that we had a lot of chaos, but the rest of the world was predictable," said Noubar Afeyan, CEO of Flagship Pioneering, the biotech incubator which founded coronavirus vaccine developer Moderna along with more than 25 other companies. "Now, we have chaos and the rest of the world has chaos, and so there are some adjustments being done."

As venture capitalists assess the damage caused by the pandemic, they appear to be treading lightly financial data provider PitchBook found biopharma venture deals are down roughly 16% compared to last year. Some firms told BioPharma Dive that, in the current environment, they'd be apprehensive to invest in certain kinds of drug companies.

Even small adjustments could have a lasting impact on the drug industry, given the vital role venture firms play in it. Many biotechs wouldn't exist without venture money and support, making these investors a powerful force over the drugs that could become available in the future.

After the recession in the early 2000s, scientific breakthroughs led to a surge in biotech investments, many of which would ultimately disappoint. When the financial crisis hit in 2008, healthcare-focused venture firms found it extremely difficult to raise money from their investors, who viewed biotech as a risky bet.

Their attitude didn't start to change until about 2013, by which time the recession was over and advances in drug research had made biotech more attractive to a wider group of investors and potential buyers. Biopharma acquisitions and initial public offerings, typically the two main ways venture firms receive returns, would hit record highs in the following years, giving these firms and their backers the confidence to keep putting in money.

Indeed, since 2013 there's been an annual uptick in the number of funding deals venture firms are doing, with almost every year having about 70 more than the one prior, according to PitchBook. By 2019, the deal count had hit 941.

The collective value of these deals, which range from small angel investments to the larger funding rounds that follow, has grown too. In four of the last five years it surpassed $10 billion.

The favorable conditions also made it so that venture firms could go back to their investors for more money. Polaris Partners, 5AM Ventures, Third Rock Ventures and Versant Ventures, among others, each secured hundreds of millions of dollars across 2018 and 2019, while Flagship, Arch Venture Partners and venBio closed new funds this spring worth almost $3 billion combined.

Deerfield, a type of investor known as a "crossover" because it invests in both private and publicly traded companies, also just completed raising $840 million to put into healthcare companies.

While money has been plentiful, the economic disruption caused by the coronavirus raises doubts about whether that will continue.

Bob Nelsen, managing director at Arch, said he'd be surprised if any new, first-time funds can raise cash at all this year. Firms with existing networks of investor relationships may be able to pull off follow-on funds, he added, but they'd likely take longer to complete.

If a slowdown persists, young biotechs could find it difficult to close their next rounds of financing. Already, the pace of biopharma venture deals appears to be lagging, as PitchBook counted 228 deals between early February and mid-May this year, down from the 271 seen in a similar time frame in 2019.

One top concern is that crossover investors, who often come in later and supply a substantial amount of the funding that props up a company until it goes public, will back away from biotech startups. Without those investors, early-stage venture backers might have to dig deeper in their pockets to push their companies forward.

"It can take $1 billion to get a drug to market," said Kristopher Brown, a partner in the life sciences group at law firm Goodwin. "There are few venture capitalists who can afford to fund that."

Nelsen predicts some crossover investors will take a break from biotech startups and focus on public stocks that are now cheaper because of a turbulent market. But Jon Norris, a managing director at Silicon Valley Bank who works on deals with healthcare venture firms, isn't so sure.

Biotech stocks have held up relatively well this year compared to the rest of the market, which Norris said bodes well for continued crossover interest. What's more, the number of biotechs that have gone public this year 14 as of May 26 is just a tick down from the 17 IPOs completed by the same date in 2019.

"It just means to me that people continue to see this sector as one that's worthy of investing," Norris said. "If you see good returns, people are not going to be quick to exit the market."

After dip, biotech stocks have outperformed the market

XBI vs S&P; 500, values indexed to Jan. 2, 2020=100

Still, much is unknown about how the pandemic will further unfold.

For drug companies, the impact of social distancing and its ripple effects on the economy are expected to be more dramatic in the second and third quarters. In a possibly foreboding sign, industry bellwethers Merck & Co. and Johnson & Johnson have lowered their revenue forecasts for the year by billions of dollars.

"I do worry about the delays that are inherent to having this whole economy come to a stop and hospital systems being overwhelmed," Norris said. "To me, that's a big deal over the next quarter."

In the meantime, venture firms need to put the money they've already raised to work.

Early-stage investors who spoke to BioPharma Dive said their core strategies are still intact in spite of the coronavirus. Flagship and Arch prefer companies with technology platforms that, in theory, can give rise to multiple drugs. Polaris, as it has in the past, works its close relationships with academic institutions to find new startup opportunities. Atlas Venture remains fairly agnostic, while San Francisco-based venBio looks for companies on track to hit a meaningful milestone in the next three to five years.

And yet, the pandemic does weigh on their thinking.

To attract new investors, development partners and potential acquirers, biotech startups need to hit goals like moving a drug into and through human testing. But they've found a new obstacle in the coronavirus. By late May, nearly 100 drug companies of all sizes had reported impacts to their clinical trials related to the pandemic.

"There could be significant dollars lost and significantly extended timelines" for biotechs on the verge of, or already in, clinical testing, said James Flynn, managing partner at Deerfield.

As such, some firms are investing more selectively. Aaron Royston, a managing partner at venBio, said his team will be "very cautious" when putting money into any drug company that's close to starting an important trial or launching a new product.

Funding also might be harder to come by for biotechs built around a single drug program, as there's not much cushioning if that program runs into complications.

"Companies that are purely based on single assets with a clinical readout are in deep shit," Nelsen said.

By contrast, companies at the earliest stages of research may benefit. Investors assume that, by the time these companies reach human trials, some of the challenges and uncertainties surrounding the coronavirus will have been ironed out.

Royston, for instance, said he has little apprehension investing in biotechs that will be working on early research for the next 12 to 18 months.

"Preclinical investment is almost a safe place to hide while everybody else is on the later-stage side, trying to figure out how to deal with delays in clinical trials," SVB's Norris said.

For now, venture firms say they've been more frequently checking in with companies that could face setbacks because of the disruption and, if needed, helping devise plans to conserve cash.

"At the end of the day, data is the currency of how we value our progress," said Atlas Venture partner Bruce Booth. "So, as long as the biotech has enough capital to get it through those data collections and can get out from some of those R&D delays, then I think we'll be in an OK place coming out of this crisis."

In responding to the disruption brought by the pandemic, venture capitalists may revisit approaches honed after the last big economic downturn in 2008.

Then, a dried up IPO market alongside difficulties raising money led some venture firms to leave life sciences investing altogether. Others doubled down on their existing strategies or adopted new ways to build companies.

Versant, for example, was known to start companies with a prearranged buyer in place. Atlas gave some companies, like Nimbus Therapeutics, a limited liability structure that made it easier to sell individual drugs to buyers, though more complicated to go public. Such tools are "less critical now than they were during that challenging period" because biotechs can still conduct IPOs, Booth says.

At Polaris, hard economic times reinforced the firm's trust in a type of group investing called syndicates, which can spread risk between firms. Flagship, on the other hand, backed away from forming biotechs with other investors because the process felt too restrictive.

"What we found was that, when people were traumatized through financing risks and through uncertainty, a syndicate was only as strong as its weakest link," Afeyan said. "In other words, if you had five investors sitting around a board table, the weakest one was the one that got to decide what you did."

Flagship has since shifted resources to focus almost exclusively on creating startups in its own labs. And it isn't alone. Firms such as Third Rock have become known for an intensely hands-on approach, incubating companies and ultimately owning significant stakes when those biotechs go public.

Another popular strategy has been to stagger, or tranche, investments to limit risk. Typically, this means firms give smaller chunks of cash early on and larger chunks later, once a startup has provided more evidence that its medicines might pan out.

And yet, despite the unprecedented challenges posed by the pandemic, venBio and others appear optimistic that a 2008-like shakeout isn't coming, and that they won't have to rely on unorthodox strategies to navigate the future. Royston's view on 2020 opportunities hasn't changed; Nelsen doesn't foresee the pandemic preventing Arch from investing right now; and Flagship is still on track to spin around 10 projects into full companies over the next year and a half, Afeyan said.

There's a key difference this time around, several firms and advisors said, and that's the money which has so far stayed readily available to healthcare investors. Cowen Healthcare Investments just last week finished raising nearly half a billion dollars, adding to the string of recent hauls from other firms.

"We've seen these things come and go, and frankly we've done some of our best companies in the down cycles," Nelsen said.

A pandemic, however, isn't just another down cycle.

Past downturns didn't threaten to overwhelm the healthcare system, as the outbreak of the coronavirus has. Hundreds of thousands of Americans have been sickened by coronavirus infections. And for millions of people with diseases other than COVID-19, how they seek and receive care changed overnight.

The widespread shutdown of businesses across the country, meanwhile, has created economic hardship not seen since the Great Depression, and it's unlikely a stop-and-start reopening will quickly heal those wounds.

"No one fully can comprehend, even in a world as smart as the biotech scientific world, the trajectory and the impact of the current situation," said Amy Schulman, a managing partner at Polaris.

Whether the pandemic persists into next year or lingers much longer, venture capitalists do acknowledge it will have profound effects on society and, by extension, the drug industry.

Nashat envisions that "new kinds of entrepreneurs" will rise amid the chaos, while others will be "scared off." Nelsen predicts big changes in how healthcare is delivered, which will "shock" the system and create new opportunities.

That means investors will need to adapt too.

"It would be incredible, to me," Afeyan said, "if people just forgot this and resumed their old normal."

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Venture capital found its footing in biotech. Then came the virus. - BioPharma Dive

Rapid Growth on Genetic Testing Market with COVID-19 Impact Analysis, Top Key Companies like Abbott Laboratories Bio-Rad Laboratories Inc.,…

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The Global Genetic Testing Market is expected to register substantial growth in the near future due to rise in incidence of genetic disorders & cancer and growth in awareness and acceptance of personalized medicines.

Genetic testing is also known as DNA testing. Genetic testing is the study of gene present in cells and tissues. This study is further applied in the field of biology and medicine to better understand genetic disorders such as cancer, sickle cell anemia, cystic fibrosis, Down syndrome, and others. The scope of the report discusses the use of gene tests for the development of personalized medicine, targeted cancer treatment, and other genetic diseases.

In addition, advancements in genetic testing techniques and increasing application of genetic testing in oncology are expected to boost the market growth during the forecast period.Genetic tests involve a set of lab tests for the study of the genetic makeup of patients and identify any gene mutations and alterations in the healthy structure of DNA leading to the development of genetic disorders. The Geographical Segmentation includes study of global regions such as North America, Latin America, Asia-Pacific, Africa, and Europe. The report is designed to incorporate both qualitative and quantitative aspects of the industry within each of the regions and countries involved in the study.

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Different top-level key players are also enlisted in order to obtain in-depth knowledge and informative data of companies. Some of the key players are also profiled in this research report, which includes Genetic Testing Market. Different industry analysis tools such as SWOT and Porters five-technique are further used while analyzing the global Genetic Testing Market.

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The report also draws attention to recent advancements in technologies and certain methodologies which further help to boost the outcome of the businesses. Furthermore, it also offers a comprehensive data of cost structure such as the cost of manpower, tools, technologies, and cost of raw material. The report is an expansive source of analytical information of different business verticals such as type, size, applications, and end-users.

Furthermore, the report also caters the detailed information about the crucial aspects such as driving factors & challenges which will define the future growth of the market.

Table of Content:

Chapter 1:Genetic Testing Market Overview

Chapter 2: Global Economic Impact on Industry

Chapter 3:Genetic Testing Market Competition by Manufacturers

Chapter 4: Global Production, Revenue (Value) by Region

Chapter 5: Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6: Global Production, Revenue (Value), Price Trend by Type

Chapter 7: Global Market Analysis by Application

Chapter 8: Manufacturing Cost Analysis

Chapter 9: Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10: Marketing Strategy Analysis, Distributors/Traders

Chapter 11: Genetic Testing Market Effect Factors Analysis

Chapter 12: GlobalGenetic Testing Market Forecast to 2025

Finally, all aspects of the Genetic Testing Market are quantitatively as well qualitatively assessed to study the Global as well as regional market comparatively. This market study presents critical information and factual data about the market providing an overall statistical study of this market on the basis of market drivers, limitations and its future prospects.

About Us:Market Research Inc is farsighted in its view and covers massive ground in global research. Local or global, we keep a close check on both markets. Trends and concurrent assessments sometimes overlap and influence the other. When we say market intelligence, we mean a deep and well-informed insight into your products, market, marketing, competitors, and customers. Market research companies are leading the way in nurturing global thought leadership. We help your product/service become the best they can with our informed approach.

Contact Us:Author KevinUS Address: 51 Yerba Buena Lane, Ground Suite,Inner Sunset San Francisco, CA 94103, USACall Us: +1 (628) 225 1818Email: [emailprotected]

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More insight into the cytokine storm caused by Covid-19 could lead to a treatment – Health24

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The immune system response triggered by Covid-19, causing an overproduction of cytokines, has been big news during the pandemic.

While Covid-19 deaths are usually caused by acute respiratory distress syndrome (ARDS), especially in older adults and those with co-morbidities, some younger Covid-19 patients have suffered severe symptoms because of an overreaction by their immune systems, rather than the virus itself.

Now, a new clinical trial will test a treatment that targets this immune response, according to a press release from the Howard Hughes Medical Institute.

The mechanism behind the cytokine storm

According to leading immunologists in Japan, a molecular mechanism could lead to possible ways to treat this overreaction by the immune system. The research was published in the journal Immunity.

The immune system response to the coronavirus may lead to ARDS, causing patients to struggle for oxygen in their inflamed, fluid-filled lungs.

"To rescue the patients from this condition, it is vital to understand how SARS-CoV-2 triggers the cytokine storm that leads to ARDS," stated Masaaki Murakami, the head of the immunology laboratory at Hokkaido University's Institute for Genetic Medicine.

His study suggested that the novel coronavirusenters human cells by attaching to the ACE2 surface receptor. Then, a human enzyme called TMPRSS2 is utilised.

"Drugs that block the ACE2 receptor or that inhibit the enzyme could help treat the initial stages of the disease," says Murakami. "However, ARDS with cytokine storm starts to appear in the later phase of infection even when the numbers of the virus decrease. So, there must be another pathway that causes the cytokine storm, Murakami explained in a news statement.

Closer to a treatment?

The treatment that will be tested in a clinical trial by the Howard Hughes Medical Institute involves a common type of alpha-blocker. Through mouse studies, the team determined that this drug might break the hyperinflammation before it causes the severe symptoms seen in Covid-19 patients.

"The approach we're advocating involves treating people who are at high risk early in the course of the disease, when you know they're infected but before they have severe symptoms. If the trial's results suggest the drug is safe and effective against Covid-19, it could potentially help many people recover safely at home and lessen the strain on hospital resources, stated Howard Hughes Medical Investigator Bert Vogelstein.

Together with his team at the John Hopkins University School of Medicine, Vogelstein is currently recruiting patients aged 45 to 85 at the John Hopkins Hospital to participate in the trial. The prerequisites are that they have to be hospitalised, but not ventilated or in ICU.

How will an alpha blocker stop the cytokine storm?

A hyperactive immune system isnt a new response solely seen in Covid-19. Usually, this type of response is seen in people already suffering from autoimmune diseases or cancer.

What happens during a cytokine storm is that cells called macrophages, which are either found in the tissues or in the blood as white blood cells, are activated to detect and fight the pathogen. As soon as this happens, cytokines are released to help the body fight off the intruder.

Unfortunately, the macrophages dont only release cytokines, but also molecules called catecholamines, which trigger the immune system to release even more cytokines.

According to the news release, Vogelsteins team was already investigating how this reaction in cancer patients could be halted with immunotherapy.

They then looked at alpha-blockers which are usually prescribed for prostate conditions and high blood pressure. This medication is meant to help curb the cells that trigger cytokine storms.

The initial research in mice was published in the journal Nature in 2018.

How likely is this method to be successful?

While alpha-blockers were already approved for human use, Vogelsteins team needed to look at medical claims data to see how patients with pneumonia and ARDS responded to alpha-blockers for unrelated conditions.

The conclusion was that the use of alpha-blockers were correlated to lower death risk, but this simply wasnt enough evidence for a new condition such as Covid-19.

Now, the patients on trial will take increasing doses of an alpha-blocker over six days. The team will then evaluate whether those patients had lower risk of ICU admission and being placed on ventilators.

A second trial will be needed to establish whether this approach is safe and effective. According to Vogelstein, this method may be great for helping to mitigate symptoms before they become severe and deadly.

"Eventually, hopefully, a vaccine will be produced, and that will be the essence of prevention," he stated. "But until vaccines are available, secondary prevention makes a lot of sense."

Image credit: Getty Images

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More insight into the cytokine storm caused by Covid-19 could lead to a treatment - Health24

insideHPC Special Report: HPC and AI for the Era of Genomics – insideHPC

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This special report sponsored by Dell Technologies, takes a deep dive into HPC and AI for life sciences in the era of genomics. 2020 will be remembered for the outbreak of the Novel Coronavirus or COVID-19. While infection rates are growing exponentially, the race is on to find a treatment, vaccine, or cure. Governments and private organizations are teaming together to understand the basic biology of the virus, its genetic code, to find what can stop it.

Significant amounts of computing power are aimed at this problem, including using the most powerful high performance computing (HPC) systems in the world today. Finding a cure or eliminating COVID-19 will not only benefit the worldwide population, but will also be the foundation for tackling the next pandemic, which some scientists say will happen in the not too distant future.

This technology guide, insideHPC Special Report: HPC and AI for the Era of Genomics, highlights a lineup of Ready Solutions created by Dell Technologies which are highly optimized and tuned hardware and software stacks for a variety of industries. The Ready Solutions for HPC Life Sciences have been designed to speed time to production, improve performance with purpose-built solutions, and scale easier with modular building blocks for capacity and performance.

Introduction

2020 will be remembered for the outbreak of the Novel Coronavirus or COVID-19. While infection rates are growing exponentially, the race is on to find a treatment, vaccine, or cure. Governments and private organizations are teaming together to understand the basic biology of the virus, its genetic code, to find what can stop it. Significant amounts of computing power are aimed at this problem, including using the most powerful high performance computing (HPC) systems in the world today.[1] Finding a cure or eliminating COVID-19 will not only benefit the worldwide population, but will also be the foundation for tackling the next pandemic, which some scientists say will happen in the not too distant future.[2]

Artificial Intelligence (AI)

Slav Petrovski, Head of Genome Analytics and Informatics at AstraZenecas Centre for Genomics Research (CGR) explains that there is a wide range of uses for AI within this field. He says that the approximately three billion base pairs that make up the human genome can be analyzed through AI to find genetic variations. The next step is to determine the level of confidence to be placed in the differing data to decide if it represents a biological genetic variant.

AI is being combined with traditional HPC simulations to predict more accurate results. Based on previous completed computations, an algorithm is able to determine what the next input or result could be. For example, if protein A shows a possible affinity to kill the Coronavirus, then does protein B (or others) have a better chance or could be more effective?

There are a number AI uses within genomics research that can identify and facilitate drug target interaction. By combining analytical and automated processes with the ongoing study of genomics, a more complete understanding of this field will progress. AI can lead to greater insights into the patterns and anomalies in the data, where humans may not see the correlations at first. By using machine and deep learning techniques, new and more effective medicines can get to patients faster and will be better targeted to fight diseases.

Produvia, a research company, has identified five areas where AI will benefit genomic research moving forward:

Precision Medicine

While AI can benefit genomic research, the end goal is to create treatments that specifically attack the genetic code of the infection or disease, and to create treatments that are tailored to an individuals genetic makeup. To do this requires significant data, computing power, and collaborations that combine expertise from many disciplines.

With a combination of faster and more accurate genomic sequencing with faster computer systems and new algorithms, the movement of discovering what medicine will work best on individual pathogens and patients has moved from research institutions to bedside doctors. Physicians and other healthcare providers now have better, faster and more accurate tools and data to determine optimal treatment plans based on more data. This is especially true for pediatric cancer patients.

Personalized or precision medicine holds the key to innovative approaches to manage diseases on an individual level. Various decisions regarding the management of healthcare to each pathogen and/or individual is customized, based on the knowledge of the genetic or cellular information. Diagnosis of diseases, and the resulting treatments can be tailored for each person. However, a number of challenges exist as this scientific field moves forward, such as regulatory oversight, intellectual property rights and patient privacy.

Worldwide, many countries are dedicating resources and efforts to learn more about genomics and how to apply this knowledge to personalizing medicine. Figure 1 shows the worldwide effort to bring precision medicine to those in need. Figure 2 shows how the cost of decoding a human genome has come down, even faster than Moores Law.

Over the next few weeks we will explore these topics surrounding HPC and AI for life sciences in the era of genomics:

Download the complete insideHPC Special Report: HPC and AI for the Era of Genomics, courtesy of Dell Technologies.

[1] COVID-19 HPC Consortium

[2] Scientists in race to protect humanity from future pandemics

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insideHPC Special Report: HPC and AI for the Era of Genomics - insideHPC

UCalgary researchers launch 360-degree study of children and COVID-19 – UCalgary News

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When it comes to children and COVID-19, we have many more questions than answers. Why are most children not getting as sick from the virus? Why are some becoming critically ill? Why are some developing puzzling symptoms? And, are children carrying the virus and spreading it silently through families and communities?

A multidisciplinary team of UCalgary researchers is studying the genes and immune response of Alberta children, and the unique genetic code of the virus itself in pan-Alberta research focused on tracking the transmission of COVID-19.

Children here in Alberta, and around the world, have milder symptoms and recover more rapidly than adults with COVID, says Dr. Jim Kellner, MD(pictured above), a professor in the departments of Paediatrics, Microbiology, Immunology and Infectious Disease, and Community Health Sciences at the Cumming School of Medicine (CSM), and an infectious disease researcher at the CSMs Alberta Childrens Hospital Research Institute (ACHRI).

We want to better understand how contagious children are, precisely how the virus is affecting their young bodies, and how children develop immunity against COVID-19.

Kellner is leading a team of 29 child health and wellness scientists and physicians to study children with COVID-19 across the province. The Alberta Childhood COVID-19 Cohort Study (AB3C) will investigate how children are responding to the infection and how they are spreading it. The UCalgary study, a collaboration between the University of Alberta, Alberta Health Services (AHS), the Alberta Childrens Hospital and Alberta Precision Laboratories (APL), is funded by Genome Alberta and the Alberta Childrens Hospital Foundation through ACHRI.

Alberta is a Canadian leader in COVID testing, completing more than 200,000 tests, testing more than 22,000 children and youth, including some with no symptoms, says Kellner, also a member of the Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, and the OBrien Institute for Public Health.

We are so fortunate in Alberta to have province-wide systems and teams AHS, APL, and electronic medical records that facilitate the study of the virus infection in children and detection of antibodies in children who have contracted the disease.

This research will draw from provincial COVID test results and collect blood, urine and stool samples which will be biobanked. Kellners team will then follow up with families to track short- and long-term symptoms of the disease and its impact on family and community members.

A member of the Canadian COVID-19 Immunity Task Force Leadership Group, Kellner will report Alberta findings to a national network of scientists, clinicians and public health experts. This powerful collaboration between a national initiative and UCalgary scientists will allow us to share detailed evidence on COVID-19 spread, the development of immunity and targets for potential treatments and vaccines, says Kellner.

Francois Bernier, left, with David Bailey of Alberta Genome.

Riley Brandt, University of Calgary

The team will also look at the biology of the virus, the childs genome and immune response to the infection. One aim of this deep dive is to study whether the virus is changing as it moves through the population. Dr. Francois Bernier, MD, head of the Department of Medical Genetics and professor in the Department of Paediatrics at the CSM and an ACHRI physician-scientist, is leading the genomics arm of the study.

Bernier and his colleagues will delve into the unique bar code of each instance of the virus itself. The genetic code of the virus is like a FedEx label, says Bernier. Deep analysis of the viruss genes will allow us to precisely trace transmission, allowing us to say This one originated in Europe, and this one came from the United States, he says.

Investigating COVID-19 in children will help scientists understand why some people become critically ill with the virus and others only mildly ill. To that end, the genomics team will also investigate the full biology of Albertans infected with the virus. The interplay between the viruss genes and the genes of infected Albertans is a key focus.

Not everyone is equally susceptible to COVID, says Bernier. We suspect genetics play a critical role.

Data mining is also essential to our understanding the complexities of COVID, he continues. We have big data experts at UCalgary who will use machine learning to give us real answers on this virus, how it is moving and spreading, and how it is interacting with the genes and the immune system of Albertans who are infected.

The multi-disciplinary team includes immunologists, epidemiologists, infectious and inflammatory disease experts, geneticists, bioinformaticians, health economists, and advanced computing experts. Bernier will share his teams data with national and international research groups including GISAID, contributing to a global effort to map the pandemics movement, its evolving genetics, and the latest development of medical countermeasures.

As social isolation policies change and we focus more keenly on community spread, it will be increasingly important to identify, quantify and track infections, immunity, and disease severity to be better able to predict and prevent the risk to children and families, says Kellner.

Information on UCalgarys response to COVID-19 can be found on the Emergency Management website.

The University of Calgary is uniquely positioned to find solutions to key global challenges. Through the research strategy forInfections, Inflammation, and Chronic Diseases in the Changing Environment (IICD), top scientists lead multidisciplinary teams to understand and prevent the complex factors that threaten our health and economies.

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UCalgary researchers launch 360-degree study of children and COVID-19 - UCalgary News

4000 Years of contact, conflict and cultural change had little genetic impact in Near East – University of Birmingham

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A 2,000-year-old individual sequenced in the study. Photo credits: Directorate General of Antiquities (Lebanon)

The Near East was a crossroad for the ancient worlds greatest civilizations, and invasions over centuries caused enormous changes in cultures, religions and languages. However, a new study of the DNA of ancient skeletons spanning 4,000 years has revealed that most of these changes had no lasting effect on the genetics of the local population of Beirut.

Whilst the invasions and conquests may have been revolutionary for the elite rulers, researchers at the Wellcome Sanger Institute, University of Birmingham, French Institute of the Near East in Lebanon and their collaborators found only three time periods that had any impact on the long-term genetics of the ordinary people. These were the beginning of the Iron Age, the arrival of Alexander the Great, and the domination of the Ottoman Empire.

Reported today (28 May) in the American Journal of Human Genetics, the study shows the value of using genetics alongside archaeology to help understand what could be happening in the lives of ordinary people throughout history.

Over the centuries, the Levant has had many different rulers, including the Egyptians, Babylonians, Assyrians, Persians, Greeks, Romans, Crusaders, Arabs, and Ottomans. Most of these had permanent cultural effects on the local population, including changes to religion and even languages, as shown by the historical records and archaeological findings.

However, despite this, previous research showed that present-day local people in Lebanon were mainly descended from local people in the Bronze Age (2100-1500 BCE), with 90 per cent of their genetic make-up coming from around 4,000 years ago, and very few lasting traces of even the Crusaders invasion around the 11th-13th Century.

To understand this potential contradiction and build a picture of the genetic history of ordinary people in the region, the researchers studied the DNA of ancient skeletons through 4,000 years. The team sequenced the genomes of 19 ancient people who lived in Lebanon between 800BCE and 200CE, and by combining with previous ancient and modern data, created an 8-point time line across the millennia.

Scientists detected lasting genetic changes in the local people from just three time periods - during the beginning of the Iron Age (about 1,000 BCE), the arrival of Alexander the Great (beginning 330 BCE), and the domination of the Ottoman Empire (1516 CE) but not from the other times.

Dr Marc Haber, first author from the University of Birmingham and previously from the Wellcome Sanger Institute, said: We revealed a genetic history of the area across 4,000 years, with a time-point approximately every 500 years. This showed us that despite the huge cultural changes that were occurring during this period, there were only a few times that the genetics of the general population changed enough to affect the ordinary people.

The study revealed that some people did mix and form families with people from other cultures. One burial site was found to contain the remains of an Egyptian mother, and her son whose father had Egyptian and Lebanese ancestry. However, this cosmopolitan mixing did not seem to be widespread.

Historical evidence is based on archaeological findings and written records, but these are biased towards the elite rulers and people with money and influence, as they have far more resources and write the history. It can be difficult to understand the lives of the ordinary people.

Dr Joyce Nassar, an author on the paper and archaeologist from the French Institute of the Near East, Lebanon, said: This study is really exciting, as the genetic evidence is helping us to interpret what we find. Some people might think that when a land was invaded, that the population would change. But this study shows it isnt that simple, and reveals there was only limited biological mixing, despite the cultural and political influence of the invasions.

The skeletons came from four archaeological excavation sites in Beirut, which were discovered during building projects in the Lebanese capital city and rescued by the Directorate General of Antiquities*. The archaeologists and researchers then worked together to transfer the bones to a laboratory in Estonia dedicated to ancient DNA, where the surviving ancient DNA was extracted from the temporal bone in the skulls. The DNA was then sequenced and analysed at the Sanger Institute. Recent advances in DNA extraction and sequencing technology made studying the ancient and damaged DNA possible.

Dr Chris Tyler Smith, senior author on the paper and previously from the Wellcome Sanger Institute, said: We see that people like the Egyptians and the Crusaders came to Lebanon, lived, raised families and died there. Their DNA sequences reveal this, but a little while later, there may be no trace of their genetics in the local population. Our study shows the power of ancient DNA to give new information about the human past, that complements the available historical records, and reveals the benefits of archaeologists and geneticists working together to understand historical events.

For more information or interviews, please contact:Hasan Salim Patel, Communications Manager (Arts, Law and Social Sciences) or contact the press office out of hours on +44 (0) 7789 921 165.

Or Contact:Dr Samantha Wynne, Media OfficerWellcome Sanger Institute,Phone: +44 (0)1223 492368

*Directorate General of Antiquities (DGA) at the Ministry of Culture is the authority responsible for the Lebanese heritage, including all the excavations led on the Lebanese territories, museums and historical buildings and cities. The DGA gave the permission to conduct DNA analysis on the material and to publish it.

About the University of Birmingham

The University of Birmingham is ranked amongst the worlds top 100 institutions. Its work brings people from across the world to Birmingham, including researchers, teachers and more than 6,500 international students from over 150 countries.

Publication:Marc Haber et al. (2020) A genetic history of the Near East from an aDNA time course sampling eight points in the past four thousand years. American Journal of Human Genetics. DOI: 10.1016/j.ajhg.2020.05.008

Funding:This work was supported by Wellcome (098051); the European Union through the European Regional Development Fund [Project No. 20142020.4.01.160030]; and the Estonian Research Council [PRG243].

The French Institute of Near East, Lebanon / Institut Francais du Proche-Orient (IFPO)The French Institute of Near East, a research centre of international renown, is organized into 3 scientific departments: Archaeology and History of Antiquity (DAHA), Arabic, Medieval and Modern Studies (DAMM) and Contemporary Studies (DC). From Beirut, where its headquarters are located, IFPO has regional competence over 5 countries with branches in Jordan (Amman), the Palestinian territories, Iraq (Erbil), and Syria (Damascus and Aleppo). The research carried out at IFPO concerns many disciplines in Human and Social Sciences, carried out through a multidisciplinary and cross-period approach aiming to understand the societies of the Near East from prehistory to the present days. For more information, visit the websiteor follow us on Twitter, Facebook, LinkedIn, and Instagram.

The Wellcome Sanger Institute

The Wellcome Sanger Institute is a world leading genomics research centre. We undertake large-scale research that forms the foundations of knowledge in biology and medicine. We are open and collaborative; our data, results, tools and technologies are shared across the globe to advance science. Our ambition is vast we take on projects that are not possible anywhere else. We use the power of genome sequencing to understand and harness the information in DNA. Funded by Wellcome, we have the freedom and support to push the boundaries of genomics. Our findings are used to improve health and to understand life on Earth. Find out more at http://www.sanger.ac.uk or follow us on Twitter, Facebook, LinkedIn and on our Blog.

About Wellcome

Wellcome exists to improve health by helping great ideas to thrive. We support researchers, we take on big health challenges, we campaign for better science, and we help everyone get involved with science and health research. We are a politically and financially independent foundation.

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4000 Years of contact, conflict and cultural change had little genetic impact in Near East - University of Birmingham

NOT REAL NEWS: A look at what didn’t happen this week – wausaupilotandreview.com

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By ALI SWENSON, ARIJETA LAJKA, BEATRICE DUPUY and AMANDA SEITZ

A roundup of some of the most popular but completely untrue stories and visuals of the week. None of these are legit, even though they were shared widely on social media. The Associated Press checked them out. Here are the facts:

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CLAIM: Video appears to show presumptive Democratic presidential candidate Joe Biden on The View avoiding a question about inappropriate touching.

THE FACTS: The video, taken from Bidens April 26, 2019, appearance on ABCs daytime talk show The View, was edited to make it appear he failed to give a direct answer to the question about inappropriate touching. The Daily Caller, a conservative website, posted the edited clip on April 26, 2019, and labeled it as satire. Social media users shared the spoof video a year later with negative comments and no satire label. Do you really want this man as your President? Seriously @JoeBiden #RacistBiden is not fit to be a leader even of his own home. Listen to him on the view. It is so funny how the ladies are trying to help him. Even put words on his mouth. Nothing worked for #CreepyJoeBiden, stated one Twitter user, who shared the video on May 25. The video features multiple misleading edits, where key portions of Bidens response were taken out. For example, in one instance, co-host Sunny Hostin asks Biden, Are you prepared to apologize to those women? In the actual exchange Biden states, Look, heres the deal, I have to be and everyone has to be much more aware of the private space of men and women and I am much more cognizant of that. The camera stays fixed on Biden. The edited clip takes out large portions of Bidens response to the question to make it appear incoherent: Look, heres the deal, I am so, like for example, I actually thought in my head when I walked out here, I mean, do I were friends. I should be able to read better. But I have never in my life done anything in approaching a woman that has been In the edited clip, the co-hosts appear shocked at Bidens response. Their facial expressions were spliced in and taken from other points of the interview. In another part of the edited clip, co-host Joy Behar says, Heres your opportunity right now to just say you apologize, youre sorry, I think we can clean this up right now. In the actual clip, she poses this comment when discussing Anita Hill. Hill accused then-Supreme Court-nominee Clarence Thomas of sexual harassment and Biden led the Senate Judiciary Committee hearing into the accusation. Clips of the original interview can be found on official accounts belonging to The View on Twitter and YouTube.

CLAIM: Two photos circulating on social media show the Minneapolis police officer who was videotaped kneeling on a black mans neck during an arrest on Monday. In one the man pictured is wearing a baseball cap that says Make Whites Great Again, and in the other he is on stage at a Trump rally.

THE FACTS: The officer, Derek Chauvin, is not in either of the photos. On May 27, a photo was shared widely on social media featuring a man wearing a Make Whites Great Again hat and holding a blackberry between his thumb and index finger. The hand appeared to be making an OK sign, a gesture that has been used widely by white supremacists. Jonathan Lee Riches, a known internet troll, confirmed he is the man in the photo, but he says the image was altered and he was not wearing the hat. Facebook and Twitter users shared the image on Wednesday claiming it showed Chauvin. In many cases the photo was juxtaposed with a photo of Chauvin kneeling on Floyds neck. Chauvin and three other police officers were dismissed from the department soon after a video emerged that showed him kneeling on Floyds neck, even after he complained of being unable to breathe. Several prominent Twitter users, including Ice Cube, posted the photo under the false impression it showed Chauvin. Riches said his face was edited into the image, but did not provide the original photo when asked. The windows and landscape in the background of the photo appear to match the backgrounds of photos Riches has posted on Facebook. Riches is known for creating outrageous posts after tragic and politically charged events. He pretended to be the shooters uncle after a 2012 elementary school shooting in Newtown, Connecticut, and was indicted in federal court in 2018 for posing as the gunman who shot former U.S. Rep. Gabby Giffords.

Other photos shared widely on social media after Floyds death wrongly claimed Chauvin was among police officers onstage with President Donald Trump at a rally in Minneapolis last October. The officers are smiling in shirts that said Cops for Trump. Photos Released on Social Media Appeared to Show Minneapolis Police Officer Who Murdered George Floyd, read the headline of a Facebook post by left-leaning news website the Political Tribune, which had racked up nearly 120,000 views on Wednesday. Did this murder Make America great again? read a post retweeted more than 1,700 times. The widespread photos actually show Bloomington Police Federation President Mike Gallagher, not Chauvin, according to Minneapolis police union president Lt. Bob Kroll. Can you put a stop to the false narrative please? Kroll told the AP. None of the officers in the incident were near the Trump rally. Gallagher did not return a request for comment.

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CLAIM: Photo shows a federal agent disguised as a protester to incite violence in the protests demanding justice for George Floyd, who died after a Minneapolis police officer knelt on his neck for several minutes as he begged for air.

THE FACTS: The photo was taken during a protest in Germany earlier this month, before Floyds death on Monday and the protests that followed in Minneapolis this week. The photo, which showed a man wearing a mask, a red hoodie and a black beanie with an earpiece sticking out underneath, circulated widely on social media. Posts cited the earpiece as evidence the man was a federal agent hiding among the protesters in Minneapolis. A reverse image search found the photo on social media posts as early as May 18, a week before Floyds death. The man in the photo was identified in posts as an antifascist taking part in protests there. The photo was shared with #falseflag hashtags, which has been used by conspiracy theorists to say that events or protests are staged, and an #AgentProvocateur hashtag. One post with the photo received more than 1,000 likes and retweets on Twitter. Anti-lockdown protesters demonstrated across Germany during the weekend prior to May 18, including in Frankfurt, where they protested against the measures enacted to curb the spread of coronavirus. The photo was shared Friday to suggest it showed a federal agent pretending to be a protester in Minneapolis, where protests some violent erupted after Floyds death in police custody. Who is this Minnesota protester taking orders from? one post shared in an online forum said. A Qanon account that also shared the photo Friday on Instagram received more than 4,000 likes. You think these events happen organically? Try again.., the post said.

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CLAIM: A photograph shared on social media shows a building fire in Minneapolis amid protests in the aftermath of the officer-involved death of George Floyd.

THE FACTS: The photo shows a mini-mall on fire during the 1992 riots in Los Angeles. As protests and riots erupted in Minneapolis in the wake of Floyds death, a Minnesota gun rights Facebook group shared a photograph of a fire crew responding to a building engulfed in flames. The post, which quickly amassed more than 27,000 views on Wednesday, addressed the states governor directly: Paging Governor Tim Walz, are you.. uhh gonna stop any of this or ? However, a reverse image search of the photo reveals it was actually taken more than 25 years ago in Los Angeles. The April 30, 1992, image, captured by photographer Mike Nelson, depicts firefighters spraying water on a burning mini-mall during the LA riots. Demonstrations rocked the city that year after the acquittal of officers involved in an excessive force lawsuit for their arrest and beating of Rodney King. Though the photo is old, it is true that Minneapolis has faced three nights of protests after the death of George Floyd, and that some of the protesters set fires.

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CLAIM: Looters steal childrens Thomas the Tank Engine mall train during Minneapolis protests.

THE FACTS: The photo of people driving a childrens train down a city street was taken in August 2014 during protests in Ferguson, Missouri. The photo circulated widely on social media this week with posts that falsely claimed protesters in Minneapolis stole the childrens Thomas the Tank Engine train from a nearby mall. Looters have stolen the childrens train out of the #Minneapolis one post shared on Facebook stated. The post had nearly a thousand shares. Another post on Twitter falsely claimed the train was stolen from the mall: Minneapolis trippin fr they stole the mall train, said a tweet posted on May 28. The post had over 8,000 retweets. On Aug. 9, 2014, white Ferguson police officer Darren Wilson fatally shot Michael Brown, who was black and unarmed. The shooting prompted demonstrations that lasted for weeks. Police responded with tear gas and rubber bullets. Several journalists covering the Ferguson protests at the time posted photos and videos on social media showing people riding the train in August 2014.

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CLAIM: Protesters looted Mall of America Wednesday night, with a video showing someone driving a car through North Americas largest shopping complex.

THE FACTS: No incidents have occurred at the Mall of America since protests erupted in Minneapolis this week, Mall of America spokeswoman Sarah Grap confirmed to The Associated Press. Social media users are falsely claiming in Facebook and Twitter posts that the Mall of America was trashed this week during protests. Some are using a 2019 video of a car driving through an Illinois mall to make the false claim. The video was taken in September 2019 at the Woodfield Mall in Schaumburg, Ill. A witness at the time captured the film of the SUV driving through the mall, sending shoppers scurrying. That witness video was used by several Chicago news outlets that reported on the incident. The Mall of America is in Bloomington, a suburb of Minneapolis, about seven miles south of the police station near where Floyd was arrested.

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CLAIM: The coronavirus has an HIV protein that proves it was genetically modified.

THE FACTS: Experts say the coronavirus has no HIV sequences in its genetic makeup. Since the early days of the coronavirus outbreak, social media posts have tried to cast doubt on its origins. Recently, online posts have tried to link the coronavirus and HIV to suggest the novel coronavirus was man-made. Those little spikes that come out of the Coronavirus and make it attach inside our lungs so efficiently are Spike Glycoproteins, better known as S-proteins for short. Well the Covid-19 strain thats currently going around has S-protein 120 spikes. S-protein 120 is only found in one other virus known to man, HIV, states a claim circulating on Facebook. It goes on to say that shows the current Covid-19 strain was indeed genetically modified by the insertion of these HIV proteins into the Coronavirus and therefore weaponizing it. Vincent Racaniello, a professor of microbiology and immunology at Columbia University, says such claims are not true. The coronavirus has no HIV-1 sequences, which can be seen by looking at the genome sequence, he said. The spike glycoprotein of SARS-CoV-2 is just like the spike of every other CoV, Racaniello said in an email. It is not from HIV-1. This post is pure nonsense, fake science, and not worth responding to. Similar posts circulated early this year after a scientific paper was published on bioRXIV, a repository for scientific papers that have not yet been peer reviewed or published in a traditional scientific journal. The paper was posted by Indian scientists who said they had found uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag. At the time, the paper was widely debunked by scientists on social media. It was withdrawn from bioRXIV following the criticism, but the paper was used as fodder for conspiracy theorists and continues to circulate online in various forms. A new version of the false claim attempts to make a link between the number (120, they falsely state) of spike proteins on coronavirus, which allow the virus to attach to human cells, and the molecular weight, 120kDa, of the glycoprotein protein on the outer layer of HIV. The gp120 protein in HIV helps the virus find a targeted host cell so it can replicate. Dr. Phyllis Kanki, a professor of health sciences in the department of immunology and infectious diseases at the Harvard T.H. Chan School of Public Health, said the 120 connection the post makes is inaccurate and means nothing. I dont know where they get this idea that it has 120 spikes, that is clearly wrong, Kanki said. It would be far greater than that. Experts further say the genes in the coronavirus spike protein and HIV gp120 look nothing alike. Its like saying that because a dog has legs and we have legs then we are both the same thing, said Dr. Joseph Petrosino, chair of molecular virology and microbiology and director of the Alkek Center for Metagenomics and Microbiome Research at Baylor College of Medicine. That 120 has nothing to do with the 120 thats on the HIV molecule. The posts also suggest that Dr. Anthony Fauci, the nations top infectious disease expert, was involved in creating the virus because he is listed on several patents related to HIV research. Fauci received the Presidential Medal of Freedom in 2008 for his work around HIV and AIDS. The false claim around the genetic makeup of the coronavirus, which has killed more than 100,000 people in the U.S. and 350,000 people globally, plays into a larger conspiracy theory that suggests the virus was made in a lab. It continues to circulate online despite the scientific proof that the virus comes from nature. A paper published in March in Nature, one of the worlds leading science journals, completed an analysis of the public genome sequence data of the virus and related viruses, and concluded that the coronavirus originated through natural processes.

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CLAIM: Italy discovers through autopsies that COVID-19 is not a virus, but a bacterium, which clots the blood. COVID-19 can easily be treated with aspirin and blood thinning medicine.

THE FACTS: Posts circulating on social media misrepresent information from an Italian study of people who died of COVID-19. The study, which hasnt been peer-reviewed, refers to COVID-19 as a virus, not bacterium. COVID 19 is for sure a virus and antibiotics do not have any effect against this infection, Aurelio Sonzogni, a pathologist at Ospedale Papa Giovanni XXIII, a hospital in Bergamo, and an author of the report, told the AP in an email. In addition, while blood clotting can occur in those infected with the disease, anticoagulants cant treat the infection. The widely-shared post contains several other false claims, including that the World Health Organization law does not allow autopsies on those who died with COVID-19. Sonzogni said that by performing 100 autopsies, they found that COVID 19 was able to trigger a damage to blood vessels of lungs and of other organs, leading to diffuse thrombotic occlusions. Thrombotic occlusions happen when a blood clot forms inside the blood vessels. According to AP reporting, its not clear how many patients with the virus develop the clots. But studies from China, Europe and the U.S. suggest that clots develop in anywhere from 3% to 70% of patients hospitalized with COVID-19. Patients commonly receive blood thinning drugs for prevention, the AP noted. The posts also falsely state, Ventilators and ICU units were not necessary, for those infected with COVID-19, and suggest that aspirin and anticoagulants can easily treat the virus instead. Some doctors are moving away from treating patients using ventilators, but it is because they are seeking new, less invasive ways of treating the virus, according to AP reporting. And while anticoagulants may be used to address blood clots, doctors cant just treat the infection with blood thinners. Clotting is triggered by many illnesses, Agnes Lee, medical director of the Thrombosis Program at the University of British Columbia in Vancouver, told the AP. We do not use aspirin or anticoagulants to treat infection. Thats not the use for these medications. Another false claim in the post states that Italy is demanding Bill Gates and the World Health Organization be held accountable for crimes against humanity for misleading, misdirecting, and withholding life saving information from the world, which cost the lives of thousands. The government has made no such demand. In the last few months, there have been several conspiracy theories swirling online that target Gates, the billionaire founder of Microsoft, for his work around vaccines. On May 14, Sara Cunial, an independent member of Italys Chamber of Deputies, made a speech suggesting that Gates should be arrested. She is part of the populist 5-Star Movement, whose founder Beppe Grillo casts doubt on vaccines, pharmaceutical companies and the health industry.

___

This is part of The Associated Press ongoing effort to fact-check misinformation that is shared widely online, including work with Facebook to identify and reduce the circulation of false stories on the platform.

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NOT REAL NEWS: A look at what didn't happen this week - wausaupilotandreview.com

Precision Medicine Market Overview By Growing Demands, Trends And Business Opportunities 2020 To 2027 – Cole of Duty

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Trusted Business Insights answers what are the scenarios for growth and recovery and whether there will be any lasting structural impact from the unfolding crisis for the Precision Medicine market.

Trusted Business Insights presents an updated and Latest Study on Precision Medicine Market 2019-2026. The report contains market predictions related to market size, revenue, production, CAGR, Consumption, gross margin, price, and other substantial factors. While emphasizing the key driving and restraining forces for this market, the report also offers a complete study of the future trends and developments of the market.The report further elaborates on the micro and macroeconomic aspects including the socio-political landscape that is anticipated to shape the demand of the Precision Medicine market during the forecast period (2019-2029).It also examines the role of the leading market players involved in the industry including their corporate overview, financial summary, and SWOT analysis.

Get Sample Copy of this Report @ Precision Medicine Market Research Report Forecast to 2029 (Includes Business Impact of COVID-19)

Abstract, Snapshot, Market Analysis & Market Definition: Precision Medicine MarketIndustry / Sector Trends

Precision Medicine Market size was valued at USD 52.6 billion in 2018 and is expected to witness 10.5% CAGR from 2019 to 2025.

U.S.Market Segmentation, Outlook & Regional Insights: Precision Medicine Market

Precision Medicine Market, By Technology, 2018 & 2025 (USD Million)

Growing demand and advancements in cancer biology will drive personalized medicine market during the forecast period. Accessibility to large-scale human genome database including next-generation sequencing (NGS) and computational tools foster industry growth. Development of innovative genetic technologies examines the functional effect of genetic makeup that leads in developing cancer, thus, should propel huge demand for cancer biology. Several such tools are widely used to study the mechanism of DNA repair, epigenetic changes related to cancer and gene regulation in cancerous cells that offer opportunities for cancer biology in personalized medicine.

Moreover, improving efficiencies within the health care system will serve to be positive impact rendering factor personalized treatment business growth. Benefits offered by personalized medicines and treatment includes target treatment for patient, optimal dosing, focus on prevention and earlier intervention as well as preventing adverse events. Thus, above mentioned features will foster the demand for personalized medication market growth. However, high cost associated with precision medicine may impede industry growth over the forecast period.

Precision Medicine Market, By Technology

Drug discovery segment held over 21% revenue share in 2018 and is projected to grow significantly by 2025. Focus of business players on developing technologically advanced drugs enabling superior treatment for several life-threatening diseases will create segmental growth opportunities. Bio-pharmaceutical companies utilize bioinformatics software to introduce customized novel drugs that should augment the segmental growth.

Gene sequencing segment is anticipated to show exponential CAGR of around 11% over the coming years. Benefits offered by gene sequencing technique such as relevant information about patients genome and biological research ensures quick drug discovery process that should boost segmental growth.

Precision Medicine Market, By Application

Immunology segment accounted for over USD 9.5 billion in 2018 and is estimated to witness considerable growth trend during the analysis period. Growing demand for bioinformatics and big data analytics to segregate human genome data obtained from immunological processes favors segmental growth.

Oncology segment held significant revenue share in 2018 and is assessed to show more than 10.5% CAGR during the forecast period. Segment growth is attributable to increasing prevalence of cancer cases resulting in development of innovative drugs with specific drug formulations in precision medicine.

Germany Precision Medicine Market Size, By Application, 2018 (USD Million)

Precision Medicine Market, By End-use

Healthcare IT companies segment held more than 27% revenue share in 2018 and will show lucrative growth over coming years. Increasing demand for developing technologically advanced tools for rapid integration, storage, and analysis of patient data should augment the business growth.

Diagnostic companies segment was valued around USD 9.5 billion in 2018. Such companies provide solutions that bridges the gap between clinical needs of patients and technology. Various benefits such as high quality of the medical diagnostic devices enabling precise patient management will foster industry growth.

Precision Medicine Market, By Region

North America precision medicine market is predictable to show around 9% CAGR over the analysis period. Rising prevalence of respiratory and oncology diseases as a result of lifestyle changes is the key factor driving demand for market. Rising healthcare expenditure coupled with presence of major industry players in North America will spur the business growth.

Asia Pacific precision medicine industry was valued more than USD 11 billion revenue in 2018. Regional growth can be attributed to technological advances in sequencing technology. Moreover, presence of large patient pool in Asia Pacific along with growing investments in R&D activities will accelerate personalized medication business growth.

MEA Precision Medicine Market Size, By Country, 2025 (USD Million)

Key Players, Recent Developments & Sector Viewpoints: Precision Medicine Market

Few of the prominent industry players operating in precision medicine industry include Biocrates Life Sciences, Tepnel Pharma Services, Qiagen, Menarini Silicon Biosystems, Novartis, NanoString Technologies, Pfizer, Eagle Genomics, Quest Diagnostics, Roche, Intomics, and Teva Pharmaceutical. The business players implement several strategies including acquisitions, partnerships and innovative product enhancement to capitalize on market growth opportunities.

Recent industry developments:

In October 2018, Eagle Genomics partnered with Microsoft Genomics to tackle computational challenges of genomics era. This partnership aimed to inculcate scale and power of cloud to precision medicine, across the production of fundamental research and core services.

In January 2018, Syapse collaborated with Roche in order to advance precision medicine in oncology. Also, this partnership focuses on clinical delivery and product development for introducing precision medicine to more patients.

Precision Medicine Industry Viewpoint

History of precision medicine can be tracked back in 1950s when Watson and Crick discovered the structure of the DNA as double-helix. Efforts to supplement the DNA structure, researchers cracked the genetic code in early 1960s. Additionally, introduction of the first DNA sequencing technology was developed in 1970s where researchers discovered first enzyme linked to individual variation in response to dosing. In early 1980s Polymerase Chain Reaction (PCR) was first discovered allowing for fast amplification of DNA sequences. These advances continued in 1990s where human genome project was launched along with FDA approval for first personalized medicine with a companion diagnostic, for the treatment of HER2 positive breast cancer. Such form of advancements continued in 2000s where first targeted therapies for lung cancer, leukemia, melanoma, cystic fibrosis, HIV, and other diseases accelerated tremendous growth opportunities for precision medicine. Moreover, increasing demand for personalized medication for secured patient management will drive industry growth during the forthcoming years

Key Insights Covered: Exhaustive Precision Medicine Market1. Market size (sales, revenue and growth rate) of Precision Medicine industry.2. Global major manufacturers operating situation (sales, revenue, growth rate and gross margin) of Precision Medicine industry.3. SWOT analysis, New Project Investment Feasibility Analysis, Upstream raw materials and manufacturing equipment & Industry chain analysis of Precision Medicine industry.4. Market size (sales, revenue) forecast by regions and countries from 2019 to 2025 of Precision Medicine industry.

Research Methodology: Precision Medicine Market

Quick Read Table of Contents of this Report @ Precision Medicine Market Research Report Forecast to 2029 (Includes Business Impact of COVID-19)

Trusted Business InsightsShelly ArnoldMedia & Marketing ExecutiveEmail Me For Any ClarificationsConnect on LinkedInClick to follow Trusted Business Insights LinkedIn for Market Data and Updates.US: +1 646 568 9797UK: +44 330 808 0580

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Precision Medicine Market Overview By Growing Demands, Trends And Business Opportunities 2020 To 2027 - Cole of Duty

It’s Way Past Time to Honor the Golden Rule – OB Rag

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by Ernie McCray

Ive been getting a few memes on my Facebook feed kind of around the theme that God doesnt give you more than you can handle.

Such a sentiment makes me shudder as people right now, who are way overburdened with a situation brought on by a deadly virus, are dying left and right all around us and all around the world.

Im not religious but I was raised in a home with people who were religious to the bone, two of the truest Christians Ive ever known: my mother, a soulful gospel piano playing woman who played for our churchs choir, and her father, my grandfather, a man who had sailed several seas and honored his Lord as easily as he breathed.

But their faith was reflected, less on cutesy Bible verses and the like, and more on just being respectful of their fellow human beings and giving way more than they received.

My point being they would never have made any struggling overwhelmed person feel at ease spouting claims that God wont allow you to be burdened too much and they, the both of them, endured and overcame a plethora of lifes daunting challenges and they gave thanks for their blessings. But they knew that didnt apply to everybody as they, as well as I over my lifetime, have seen many folks go under because they couldnt handle their lifes conditions.

They modeled, for me, how Christians should be although Ive shed much of the pure sacredness aspects of my upbringing as religion has simply, to myliking, been too full of hallelujahs and you cant do this and you cant do that and talk about the devil and the enemy and stuff like that.

However, what I took from that was a Do unto others what you would have them do unto you philosophy that has guided my behavior throughout my life.

Like in sports I was in an opponents face like Sherlock Holmes on a murder case but I never tried to hurt anybody intentionally because I didnt want anybody trying to injure me.

On the playground I stood on the sidelines of the Yo Mama putdowns and other such trash talking traditions of renown because I didnt want to hurt anybodys feeling and didnt want anybody to hurt mine.

The Golden Rule has suited me just fine.

And that brings me back to this day and time, to my Facebook timeline that expresses a few of my friends religious beliefs, their need to praise their God, something I fully understand, but I wish theyd be considerate of others when they post sentiments like:

Gas in the Car!Still got a job!Somebody needs to tell GodThank you!!!

Their feelings inspired a range of true dats and amens and I, too, felt thankful that so far, at least, Im not having any trouble making ends meet but Icouldnt help but wonder how such a message resonated with someone who:

cant pay their bills,keep food on the table,gas up their carand has no job.What should theytell God?

I wouldnt, if I were one of them, want to be greeted online with rejoicing that treated me as if I and my misfortunes didnt exist.

So, it seems to me, and Im sure my mom and granddad, if they were still around, would agree that if were to get through our ordeal as a world of people, we will simply have to treat each other the way wed like to be treated.

A world honoring the Golden Rule is an idea way past its time as such behavior might be the answer to what our collective duty should be all about during these times: saving humankind.

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It's Way Past Time to Honor the Golden Rule - OB Rag

The Class of 2020 | Class of 2020 | tetonvalleynews.net – Teton Valley News

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I take my cowboy hat off to the graduating class. This year has been peculiar. Doubt that any will surpass.

But one thing is for certain. Its a gamble worth the bet. The year of 2020 you will dang sure not forget.

Some have given up and sure to cause them certain strife, but you have reached your first achievement in your many days of life.

Youre young and full of spirit, like a filly shakes her tail. Never give up dreaming cuz youre afraid that you might fail.

A cowboys life aint cheap and with equipment comes expense. A healthy education brings you more than just horse sense.

So be diligent when studying. Youve got no time to shirk. And if you plan on making bank, for sure its worth the work.

Theres more to life than money, but it takes a lot to live. So, choose an occupation where youll have some left to give

To someone wholl be starting out, the way you are right now. Youll soon find out that everyone can use a break somehow.

Remember, in this life theres not a single thing for free. Somebodys got to pay it and its usually you and me.

Exhibit deeds of kindness. Cowboys have a Golden Rule. Youll treat each other with respect. If not, then youre a fool.

Some days will be discouraging. You wont know what to do. But this cowboys telling you therell be a light come shining through.

Your best years are ahead of you. Be ready for each task. Your God is there to help you. All you gotta do is ask.

So, congratulations seniors. You are gonna love the world. Take a step and cowboy up. Youre about to be unfurled.

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The Class of 2020 | Class of 2020 | tetonvalleynews.net - Teton Valley News

Rules, Rescheduled Games and a Covenant Worth Preserving – The New York Times

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The Premier League Handbook is so long that calling it a handbook is, in many ways, a bit of a stretch. It runs, all told, to 665 pages. It falls somewhere between a particularly dense instruction manual and an especially didactic piece of scripture.

It lays out, in a sea of sections and subsections, exactly how a club must be run if it wishes to be part of the most popular domestic sports league in the world. And exactly means exactly: No stone is left unturned, no detail uncovered.

What players must wear while performing off-field duties: clothing bearing the clubs crest. How long a postgame warm-down can last: 15 minutes, and not a second longer. What teams are and are not allowed to show on the big screens in their home stadiums: no rolling live footage, thank you very much.

The only thing that is not included, as became abundantly clear on the evening of March 13, is what might happen if the league season cannot be completed. Section C The League Championship had nothing to say on the matter.

The handbook will, presumably, be updated; there is already a 50-page appendix governing how teams should safely return to training in the midst of the coronavirus pandemic, which forced the seasons suspension more than two months ago. That will be done either by decree or according to precedent, but the absence of such instruction felt then (and it still feels now) like something of an oversight.

The arrival of an aggressive pathogen is, after all, not the only thing that might have caused the cessation of soccer. War has done it in the past, civil unrest has done it elsewhere, and player strikes have managed it in other sports. Given soccers economics, it is not entirely unimaginable that the collapse of a broadcast partner might pose an existential threat, too.

But the handbook did not offer guidance. This was the one eventuality nobody seemed to have considered. It spoke only silence. And so, for the last two months, there has been nothing but noise.

Over the course of hours and hours of meetings and days and weeks of whisper and suggestion and briefing the executives of the Premier League have tried to conjure an answer to the one question none of them had ever previously felt the need to ask.

Only on Thursday, as the end of May drew close, did they land upon one. In Germany, the Bundesliga had already been playing for two weeks. In Spain, the games authorities had long since committed themselves to playing out the season. In France, where the leagues hand was forced by the government, Paris St.-Germain had already been named champion.

Now, at last, England has a way forward, too: The Premier League will return on June 17, as long as it retains political permission and there is no spike in either the positive tests returned by players or the infection rate across Britain.

If the league cannot return, the season will be determined on a points-per-game basis (effectively freezing the table as it stands, with one or two exceptions). It will name a champion. It will relegate its three worst teams. At last, the idea of null and void is off the table.

For a while, that seemed to be the preferred solution of a number of teams who exist entirely to play soccer. For some time, there has been a constituency in the Premier League to whom all that matters is being there: not excelling, not winning games, not entertaining anyone, but simply existing in the top flight of English soccer. Null and void seemed to be the natural conclusion of that approach: It did not matter if anyone played soccer at all, it turned out, as long as they could keep cashing those television checks.

It was initially dressed up in an understandable, fairly compelling, morality: The very idea that soccer should return was almost offensive, they said. Then, later: The idea that the season should be played out in empty stadiums, compromising its integrity, was unfair, they said. Then, later still: Soccer could be played without fans, they said, but not at neutral venues; or it could be played at neutral venues, but nobody could be relegated.

There is merit to some of these arguments. Certainly, in April, it felt distasteful to try to map out the return of a mere sport (we have established previously that it is morally OK to miss sports, no matter what else is going on) as the pandemic raged at its peak and it seemed there was no end to the nightmare.

Less significantly, the Bundesligas experience does suggest that the absence of fans has a dramatic impact on results: Home-field advantage seems, almost overnight, to have disappeared in Germany. And it is true that the desire to play games at neutral venues in case crowds gather outside stadiums is, in essence, an egregious insult to those fans upon whom the entire edifice rests.

That those arguments have not won the day, though, is a relief. Not because the only fair way to settle the season was always to play it out. Not because of the economic imperative for the health of the clubs and, to some extent, the game as a whole to find a way back.

And not because it is necessarily right that soccer will return. It remains, after all, a delicate balance. There is no guarantee that the English or even the German season will be able to finish. It may well be that one or both will be decided, in the end, off the field, by some mathematical formula.

But that is vastly preferable to voiding it, to scratching it from the record books, pretending it never happened, starting over whenever we can. Not because that was never really necessary, or because it is inherently unfair, or because it prioritizes things that did not happen over things that did. No, it is preferable for a much more fundamental reason.

There is a covenant between fans and the sports they follow. It assures that what the fans are watching, what they are investing their time and money in, counts for something. It matters. It has meaning an artificial meaning, something that we impose, rather than something inherent, but a meaning nonetheless.

To write off the season, then, would not only strip the first nine months of this season of that meaning, it would also jeopardize the meaning of any season in the future. It would make it hard to invest financially in a season ticket or a television subscription. More important, frankly, it would make it hard to invest emotionally in a team again.

Why would you, after all, if someone might tell you a few months later that what you were watching happened, but didnt count, didnt mean anything? Voiding the season would have ruptured the bond we have with the sport. One of the rationales you hear, frequently, from those who would have abandoned it is that at a time like this soccer doesnt matter. Cancellation would have been confirmation that it doesnt matter at any time.

That, perhaps, is what the revised Premier League Handbook should reflect. Just an addendum to Section C: a clause that says, in case the worst should happen again, what you are watching, what you are playing in, what you are part of, cannot be extinguished by some force majeure. It will all, in the end, count for something.

This Is the Future, for Now. We Might as Well Try.

There is a golden rule of the internet. It is not, despite what a lot of people think, Godwins Law. It is this: If you put something online, at some point in the process some man and it is, essentially, always a man will hijack it for the purposes of some form of sexual gratification.

And so nobody, but nobody, should have been surprised on Thursday that when the Danish club AGF Aarhus invited fans to follow its first game of the resumed season on Zoom, two men had to be cut from the feed by the clubs moderator for exposing themselves. (Thankfully, before their little stunt had been seen by anyone.)

It is a bleak reality, dont get me wrong. It isnt funny. I cant explain it. I dont even begin to understand it. But it should also not distract from the fact that there is something encouraging in Aarhuss experiment. If we accept that fans are not going to be in stadiums for some time, then clubs, leagues and broadcasters should be looking for ways not so much to soften the blow, but to adapt.

In Germany, the leagues broadcaster is offering ambient crowd noise to viewers watching at home. In South Korea, it was pumped directly into the stadium. Bringing fans into the stands through Zoom is a valiant attempt to go a step farther. (Our friend Tariq Panja wrote about the AGF match, and the video is fun.)

All of these modifications are anathema to the purist, of course. But to reuse a phrase the perfect cannot be the enemy of the good. Fans cannot go into stadiums. Soccer can spend the coming months bemoaning that. Or it can find a way to make this reality as palatable as possible. Who knows? Perhaps some of the ideas might last longer than the crisis.

Sadly, Necessity Doesnt Always Bring Invention

There was a suggestion, presented to me by a friend not long ago, that could solve so many problems, and that made such perfect sense, that it was inevitable, really, that English soccer should ignore it completely.

It ran like this. The glamour and significance of the F.A. Cup have been fading for years. It now ranks, for most teams, as either a nuisance or an afterthought. Its a competition for the reserves and the squad players and the stiffs. Many fans treat it with contempt. It serves, too often, as an unwelcome interruption of the league season.

But this years edition would need to be finished. So, rather than trying to squeeze it in amid a breathless schedule of Premier League games, why not wait? Why not allow the league to finish, and then play the last three rounds of the Cup quarterfinals, semifinals, final in a single week, all at the same location?

It would be an emergency measure, of course, given the circumstances, but there is absolutely no reason this should not be how the F.A. Cup works in future. It is perfect: Rather than cluttering up the calendar and disfiguring the league through March and April, the cup can be put on ice from the quarterfinal stage. Everyone gets a bit of breathing room, some time to think.

And then, once the league is done, when fans around the world are searching for something to watch, you have a week of high-stakes Cup games: a compelling mini-tournament that functions, as the cup final always did, as the natural conclusion and climax to the season. It is simple, and it is perfect.

On Friday, the F.A. confirmed it was doing something else entirely. Some people just do not want to be helped.

Last weeks column on the effect of Athletic Bilbaos buy-local approach to transfers prompted quite a few questions. Patricia Zengerle had mixed feelings about the idea, asking: In an international, multicultural sport, does the team stay white white white? The answer is not entirely Athletics star performer this year has been the striker Iaki Williams and the policy does not officially see color, as it were. But (without having conducted a survey) I would guess that Athletics team is whiter than most in Spain, and has been for some time.

Daniel Arbelaez wrote that the underlying elements of nationalism in the policy were disturbing. Edward Baker pointed out that Athletics definition of Basque can be traced to Sabino Arana, the father of Basque nationalism, who is now widely regarded as a problematic figure. There is nothing, absolutely nothing, charming about this repulsive blood-and-soil nationalism and its expression in the history of Athletic de Bilbao, Baker wrote.

There is, of course, an uncomfortable undertone to the roots of Athletics approach, and one that should have been acknowledged; these are valid critiques. So, too, is the reminder from the author Phil Ball that other teams in the Basque region tend to suffer from Athletics predation of the best local talent.

It would not be possible for Athletics model to be implemented directly elsewhere; in an ideological sense, it would not necessarily be desirable. Last weeks column was an attempt not to condone that, but rather to suggest that what could be learned is that it is possible both to find pleasure in and to take pride from a sports team while accepting that it will not win all of the time.

Mere mention of Sporting Clube de Portugal, too, encouraged Francisco Valente and he was not alone to set me right. The reason we dont use Sporting Lisbon is simple: We are proud to support a club that, despite its Lisbon origins, became a national one, bringing together supporters from all corners of our small country, he wrote. Hes right, too. It turned out it was quite a bright idea.

Thats all for this week. Thanks for all the messages. As ever, ideas, hints, tips and assessments of controversial Spanish historical figures are all welcome at askrory@nytimes.com, or on Twitter. We talked about how coaches manage players on this weeks Set Piece Menu. And feel free to send your friends and relatives here, and tell them it has made lockdown a little bit more bearable for you.

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Rules, Rescheduled Games and a Covenant Worth Preserving - The New York Times

Cepeda: The War on Masks is yet another battle dividing our country – Roanoke Times

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LAKE GENEVA, Wis.- This quaint downtown looked unremarkable on a quiet, rainy Monday morning: Businesses were starting to open, traffic was light. Clusters of teens, elders with dogs, and people carrying bundles of mail for the post office strolled down the street almost none wearing protective masks over their nose and mouth.

I broke quarantine to bear witness to Wisconsins mixed status. Many of the states larger metropolitan areas such as Madison and Milwaukee are retaining most of the governors safer-at-home measures to combat the spread of coronavirus. Meanwhile, the rest of the state is taking advantage of the Wisconsin Supreme Courts decision to strike down the order to stay closed giving them the option to roam free.

Tiny towns bordering Illinois took a turn in the Chicago media spotlight as refugees from the windy citys far off exurbs crossed the border to sit at bars with others who just wanted a cold beer and a cheeseburger amid all this COVID-19 craziness.

Over the weekend, the resort town of Lake Geneva was reportedly hoppin with visitors from both sides of the border, and many of them were promenading down the main drag, hitting the beach and taking cruises on the lake.

All for it, Dave Gragnani of close-by McHenry, Illinois, told the Wisconsin State Journal. He added that he planned to visit a coffee shop and a skatepark without a mask or hand sanitizer. People should have a choice. Im having a wonderful time.

Truth be told, I, too, had a wonderful time Monday, as the rain fell softly outside of Jonis Diner, a local favorite that bills itself the Best Breakfast in Lake Geneva. Walking into the 1950s-themed replica railcar after months of eating at home or while driving in the family minivan was, well, a relief.

The experience was a little weird, though there was no counter seating, and each set of visitors sat with an empty booth between them and the next diners. There was also only a limited number of items on the table (no creamer, ketchup or mustard sitting out, for instance).

The small, mom and pop business relies almost entirely on seasonal tourists to get through the year financially, but the waitress said they were wading back into sit-down service slowly and carefully.

The staff seemed just as relieved to be back to work as I was to have delicious diner coffee and a fresh, crisp golden Belgian waffle with full-sugar syrup.

None of the staff wore masks, and though my husband and I wore masks in, we kept them off during the meal. We also kept our distance, if thats even a sufficient manner of avoiding infection.

Condemn me if you will, but I had an opportunity to venture out of my hiding hole and took it. I relished it, thanking the universe for keeping me from political confrontation.

In some places, like the grocery store, you get the glare or side-eye if youre not wearing a mask over your face. In others, like Walmart, the hardware store or the gas station, you might get a weird look if you are wearing a mask.

Some assume that those who wear a mask are weak willed, easily brainwashed and possess socialist leanings. Instead, the person wearing the mask might instead just be covering their mouth and nose as a courtesy to others, including the elderly and immunocompromised.

Those who do wear masks might look at those without a face covering and think that he or she doesnt believe in science and is a selfish supporter of President Trump. And those who dont wear masks might rebut this with sincere beliefs about individual liberties and choice.

The war on masks is a way of taking a public health crisis a situation that demands political unity and best practices in governance and reshaping it into a culture war competition, wrote Zack Beauchamp on Vox.com. The question is not are we doing a good job handling this so much as whose team do you want to be on, the namby-pamby liberals or the strong fearless conservatives?

Masks and restaurant and bar visits have become a point of contention all over the country, fueling violence against innocent frontline food and restaurant employees who are just doing their best to stay healthy while working a high-touch, minimum wage essential job.

Its a tough time all around. Just remember, as we start venturing out of quarantine, to be nice and follow the golden rule. It stands up well through times of trauma: Treat others the way youd want to be treated.

Cepeda is a columnist for the Tribune Content Agency.

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Cepeda: The War on Masks is yet another battle dividing our country - Roanoke Times

Henry Cejudo Breaks the Golden Rule of Pro Wrestling After His AEW Debut – Essentially Sports

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All Elite Wrestling has been on a roll in the past few weeks. After a blockbuster night at Double or Nothing, the promotion has presented some spectacular episodes of Dynamite with the recent brawl between Mike Tyson and Chris Jericho getting unprecedented attention for the company. Another man who has been in the spotlight is former Olympic gold medalist and UFC legend Henry Cejudo.

The American mixed martial artist has been acting as an ally of Iron Mike in his beef with Y2J. Needless to say, fans are dying to see Cejudo mix it up with Jericho and his Inner Circle. However, recent actions by Cejudo have left a sour taste in their mouths.

A video has been doing the rounds on social media where Cejudo can clearly be seen breaking kayfabe. Triple C can be seen making a video where he is enjoying a laugh with Chris Jericho backstage.

Now, many of you might think that this is just overreaction as kayfabe is a myth in modern pro wrestling. WWE has acknowledged that fact and it repeatedly telecasts programs like 24 on the WWE Network where on-screen rivals are seen chilling with each other behind the scenes.

However, for the core fanbase of Professional Wrestling, this is what has pushed them away from the company. Even if fans know that the action is scripted, they want the realism associated with the product to sustain.

If you recall, the most popular days of wrestling in the Attitude era saw superstars like Steve Austin and The Rock maintain kayfabe even when they are not in action. Recently, Broken Matt Hardy became popular because of this strict adherence to his character even during interviews.

AEW has been developed by Cody Rhodes and The Young Bucks on the premise of being a different product. They had pledged to save professional wrestling by taking it away from cheap theatrics to some real cold-blooded action.

It can be argued that Henry Cajudo being seen with Jericho backstage takes a lot of steam away from this angle. These are the avoidable mistakes which the company needs to do away with.

Do you think kayfabe is still an integral part of the business?

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Henry Cejudo Breaks the Golden Rule of Pro Wrestling After His AEW Debut - Essentially Sports

Opinion: "The only thing necessary for the triumph of evil is for good men to do nothing" – CT Examiner

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Dad, did you see that another black man got killed by the police?

Yes, I did. What do you think about that?

Its crazy, clearly he was down. People were standing there watching them telling them to stop. The other police was just standing there. It was crazy!

And so began another conversation about the realities of life with my fourteen-year-old daughter.

Hate is a strong word. I dont use it flippantly. But, I hate the abuse of power! Thats what we witnessed: bad police officers abusing their power.I like the police. I appreciate their service to our community. I dont like that there are bad police who abuse their authority. I know good police officers, and I know that they dont like bad police officers either. I know one good police officer who exposed the abuse of other bad officers on the police force and it cost him his job. That might be part of the reason why bad police officers stay in their positions. They seem to leave a wake of victims.

Abuse of power isnt unique to the police. If you give a person power, or authority, they might abuse it. Ive seen ministers abuse their power. Ive also seen congregations abuse their ministers. At some point, weve all been aware of a boss who was abusing power. Im in the middle of a political campaign. Good thing politicians dont abuse their power!

Edmund Burke once said, The only thing necessary for the triumph of evil is for good men to do nothing. As a black person this gets complicated, frustrating, infuriating. When a video like the George Floyd video emerges, black people get upset. When the response to our anger is excuses, deflections, and outright silence from our white brothers and sisters complication, frustration, infuriation. Sometimes I am asked if I would feel the same way if this kind of thing happened to a white person. My answer is, YES! Injustice is injustice. I have profound sadness that injustice happens more often to people of color. I dont want it to happen to anyone. I also dont understand how videos of abuse that seem to surface on a regular basis do not motivate people to do right, seek justice, work to weed out the bad apples, and call upon our authorities to police themselves.

Let me be clear, rioting is not the solution. Neither is blaming victims by pointing out their personal flaws, or the problems plaguing their community. I can attest that black community leaders speak out about the issues in their communities. Ministers, teachers, politicians, and community elders preach and teach the importance of education, self-respect, faith, and the Golden Rule. They do this when no camera is around. When a camera is thrust in their face, they cry injustice. The response they often receive is that they are shouting at the wrong people, and that they need to speak to their own people. They already have spoken to their own people and they will continue to speak to their own people when the camera goes away.

The argument becomes us vs. them, black vs. white, liberal vs. conservative. It is no longer about resolving an injustice, its about winning a debate. Edmund Burkes words become a prophecy fulfilled in front of our eyes: Good men do nothing.

If I was not running for political office, I would have thought these ideas and may have even put them pen to paper, but I would not have had a forum to share them. So while I have this forum, I will share. And I will conclude by asking a personal favor of you.

Never be afraid to approach me if you see me acting in an unjust manner. I understand that if I win this election, I will receive authority. I dont want to be corrupt. I want to help people, not hurt them. Sometimes even folks like me can be tempted to stray off track. So pray for me, and feel free to hold me accountable. I need it and you deserve it!

Brendan Saunders

Saunders is the Republican candidate for the 33rd District state senate seat for Chester, Clinton, Colchester, Deep River, East Haddam, East Hampton, Essex, Haddam, Lyme, Portland, Westbrook and Old Saybrook

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Opinion: "The only thing necessary for the triumph of evil is for good men to do nothing" - CT Examiner

I Have a Dream – The New York Times

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THURSDAY PUZZLE Man, did this one ever take me down. Congratulations to the constructor, Tracy Bennett. You win. And its only Thursday.

Maybe I just wasnt on the same wavelength with her today, because this is a great puzzle. Its clean and filled with a lot of exciting entries, AS NEAT notwithstanding. The theme is excellent. And yet it gave me more trouble than the average Saturday puzzle.

At first I thought it might contain a rebus element, because that is often the culprit when I am struggling to make progress in a crossword. Its not a rebus puzzle.

There was a lot of general knowledge in Ms. Bennetts puzzle, and the clues seemed a bit tougher than usual, but in general I think I just wasnt braining well today. These things happen.

5A. I totally missed this one. Hunk did not inspire me to think of GOB, but I guess they are synonyms: You can have a hunk of something and a whole GOB of it as well.

36A. Dont panic. We are not thinking of that kind of flasher. A Flasher at a rock concert is a STROBE light.

40A. My brain which totally betrayed me today, in case I havent mentioned it got stuck on the word unto for the clue Golden rule word. That doesnt fit, however. We are supposed to do unto OTHERS.

41A. Shout-out to Sam Ezersky, our associate puzzles editor and an alumnus of the University of Virginia. I didnt not know about the famed serpentine garden walls.

46A. I missed this one, too. The Confucian scholar in the clue is Chu HSI.

52A. Just stopping here to mention that this theme clue was initially my least favorite until I thought about it some more and then it cracked me up. The singer Barry White was known for his low baritone and would definitely be beyond the range of THE SOPRANOS in a singing contest.

59A. I had HALITE for the longest time and when the T was marked wrong, I ran through the alphabet to find the missing letter. Fortunately, I didnt have to go too far. The answer is HALIDE.

60A. The use of Just deserts versus Just desserts comes up a lot, so I will just leave this here for those who want to argue. The Cause of just deserts not desserts is BAD KARMA.

2D/3D. I liked the side-by-side clues Snorty ride (STEED) and Sporty ride, informally (VETTE).

25D. The DAW is a cousin to the black crow. Its been in the New York Times Crossword 75 times. You would think I would know it by now.

31D. I will freely admit that I asked my kids about this one. The Playable kid in the Super Smash Bros. games is NESS. By the way, if you ever run into my children and they challenge you to a game, do not play them for money.

45D. Like many of the clues in this puzzle, I went in the wrong direction for this one. Things many people work on all day long sounds like projects to me, but no, its DESKS.

This theme hit me in two parts, which for my money was part of the fun. Two television shows are mashed together to make a wacky phrase.

At first I thought only the first part of each theme phrase was a TV show, but no, the theme was a two-word show plus a one-word show. For example, at 19A, the answer to the clue What to do if you want to win bar trivia? is GET SMART FRIENDS. That is the sitcom GET SMART plus the sitcom FRIENDS.

And look at some of this fill: VISIGOTHS! SMARM! FREE AT LAST! BAD KARMA! What a fun puzzle. I wish I could have solved it.

These days, most puzzle themes come to me in the liminal space between dreaming and waking. Other times Ill stumble on an idea while Im in a rabbit hole, researching a clue in editorial or fact-checking mode.

I dont remember how this theme idea began, but I do recall that the R&D phase was absorbing, because it involved sorting, combining and regrouping, tasks that I find soothing whether Im manipulating words, colored pencils or socks. I wanted to achieve formal as well as syntactic integrity in the theme, so I ultimately focused on television shows that would fit a two-word plus one-word pattern, though I considered other permutations along the way.

The first version I submitted had four entries, two of which were deemed stronger than two others. (Alas, my Kung Fu Entourage will have to kick ass in another theme.) I did a second round of brainstorming, and we settled on three solid 15s in a 72-word grid.

Its great to be back in The New York Times. I miss seeing my tribe at the A.C.P.T.!

Almost finished solving but need a bit more help? Weve got you covered.

Warning: There be spoilers ahead, but subscribers can take a peek at the answer key.

Trying to get back to the puzzle page? Right here.

Your thoughts?

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I Have a Dream - The New York Times