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RibFest goes drive-thru – Medicine Hat News

Posted on July 10, 2020 by Danzig

By MO CRANKER on July 10, 2020.

While COVID-19 has cancelled quite a few events this year, RibFest will still be happening.

The event will run differently, using a drive-through format, and funds raised will go to the Rotary Club of Medicine Hat.

This years RibFest will be running August 7-9 and four different rib vendors will be selling their southern barbecue classics. There will also be a Tater King booth and a lemonade stand.

Its going to be just like grabbing a coffee, but with southern barbecue, said organizer Andrew Reinhardt.

The event will run from 11 a.m. to 9 p.m. on Friday and Saturday at Murray Chevrolet. Sunday will run from 11 a.m. to 7 p.m.

People will enter the Murray parking lot in their vehicles and pick one of four lines to get into. They will drive up to a cashier with an iPad, place their order, pay with either cash or debt and then grab their food.

The cashier will operate the iPad so people dont have to themselves, said Reinhardt. People can stay in their car the entire time.

Reinhardt says the rib trucks are highly efficient and can do an order in 15-20 seconds and that they are expecting 2-2,500 cars over the weekend.

This is a safe fundraiser and were going to meet every guideline for Alberta Health, he said. I know people are dying to do something and this is going to be a fun event.

There will not be tables set up this year for people to sit and eat at, because of the ongoing COVID-19 pandemic.

Rotary Club treasurer Gail Halderman says the group is still looking to get sponsors on board and that it is planning on selling pop and other things to raise a bit of money.

Were holding this to get money so we can give back to the community, he said. We do a lot of work in our community like the Rotary Music Festival every year. We also put over $100,000 into a trail project last year that went from Desert Blume back to Medicine Hat.

The event has been held in previous years to support the local chapter of Big Brothers Big Sisters, but money from every sale will go to Rotary this year instead.

The RibFest people approached me and our board thought this was a great idea, said Halderman. We know they work with a lot of Rotary groups and were looking forward to this opportunity.

More information can be found by searching for Medicine Hat Rotary Drive Thru Ribfest on Facebook.

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RibFest goes drive-thru - Medicine Hat News

Nuclear Medicine Equipment Market In-Depth Analysis and Forecast 2017-2025 – Cole of Duty

Posted on July 10, 2020 by Danzig

Global Nuclear Medicine Equipment Market: Overview

Nuclear medicine equipment include special imaging devices such as single-photon emission computed tomography (SPECT) and gamma cameras a.k.a. scintillation cameras for diagnosing and treating chronic diseases such as cancer. Composed of radiation detectors, gamma cameras help to identify radioactive energy emitted from the patients body and converts it into an image. SPECT could work in combination with gamma cameras for producing 3D or more detailed images. This could be done with the rotation of gamma camera heads around the patients body.

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Global Nuclear Medicine Equipment Market: Key Trends

Over the course of the forecast period 20172025, the world nuclear medicine equipment market is prognosticated to register an attractive growth owing to some reliable factors. There could be favorable changes taking place in the world nuclear medicine equipment market on account of technological evolutions such as hybrid imaging, improvements in molecular imaging that do not necessitate radioisotopes, and the introduction of new radiopharmaceuticals to help in diagnosis and therapy.

However, lack of molecular and anatomic imaging training, insufficient evidence and data to support the capability of nuclear medicines to improve patient results, lack of cost-effectiveness, and lessened medical imaging reimbursement could pose some challenge to the world nuclear medicine equipment market. Nonetheless, market participants are predicted to be blessed with some profit-making business opportunities in the coming years.

The growth of the world nuclear medicine equipment market could be attributed to the exclusive benefit of specific deliverance of non-invasive and unique approach to data at cellular and molecular levels, which otherwise cannot be reproduced with the help of other imaging procedures. Against the background of the rise in awareness about chronic diseases, the world nuclear medicine equipment market is expected to witness a higher demand because of the advantage of earlier detection. A positive effect on the growth of the world nuclear medicine equipment market could be anticipated with the increase in diagnostic nuclear medicine procedures conducted on a worldwide platform.

Global Nuclear Medicine Equipment Market: Market Potential

The King Hussein Cancer Center (KHCC) in Jordan has appreciated the support of the International Atomic Energy Agency (IAEA) provided via the 2015 Practical Arrangements agreement between the two entities. Development of the IAEA Curricula for Nuclear Medicine Professionals, arrangement of clinical practices workshops and meetings, and direct training of nuclear medicine professionals are the three key areas of the collaboration. KHCC believes early diagnosis and treatment of cancer through nuclear medicine technologies and techniques are vital for improving the cure rate among patients.

Global Nuclear Medicine Equipment Market: Regional Outlook

The U.S. nuclear medicine equipment market is prophesied to testify a remarkable progress on the back of several technological advancements, thus raising the hopes of vendors operating in North America. As a result, North America could well run for attaining a dominant position in the international nuclear medicine equipment market. One of the factors that is envisaged to be responsible for the growth of North America is the rapid advent of novel radiopharmaceuticals for the purpose of conducting therapeutics and diagnosis.

Actively participating countries such as Japan could help the Asia Pacific nuclear medicine equipment market to grow at a faster rate. The analysts foresee Japan as a larger consumer of nuclear medicine equipment in Asia Pacific. Moreover, the country could exhibit a high development of nuclear medicine practice due to a telling increase in the count of hybrid SPECT/CT examinations performed in the recent past. Other countries such as India and China are foretold to expedite the growth of Asia Pacific with an augmenting demand for the diagnosis and treatment of Parkinsons and Alzheimers diseases.

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Global Nuclear Medicine Equipment Market: Competitive Landscape

The worldwide nuclear medicine equipment market could be branded by consistent elements that direct price trends and other vital factors. Envisioned to carry a secular nature, the worldwide nuclear medicine equipment market could bear the presence of top players such asSiemens Healthineers, Philips Healthcare, GE Healthcare, Digirad Corporation, and DDD-Diagnostics A/S.

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Nuclear Medicine Equipment Market In-Depth Analysis and Forecast 2017-2025 - Cole of Duty

Surge in the Adoption of Aesthetic Medicine And Cosmetic Surgery to Fuel the Growth of the Aesthetic Medicine And Cosmetic Surgery Market Through the…

Posted on July 10, 2020 by Danzig

A new intelligence report Aesthetic Medicine And Cosmetic Surgery Market has been recently Added to Aesthetic Medicine And Cosmetic Surgery Market Research set of top-line market research reports. Global Aesthetic Medicine And Cosmetic Surgery Market report is a meticulous comprehensive analysis of the marketplace which offers access to direct first-hand insights on the growth path of market at near term and long term. On the grounds of factual information sourced from authentic industry pros and extensive main business study, the report provides insights about the historical growth pattern of Aesthetic Medicine And Cosmetic Surgery Market and current market scenario. It then provides brief and long-term market growth projections.

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Competitive Businesses And Manufacturers in global market

key players in aesthetic medicine and cosmetic surgery market areAllergan, Inc., Alma Laser, Cynosure, Galderma S.A., Lumenis, Johnson and Johnson, Solta Medical, Inc. and Syneron Medical Ltd.

The research report presents a comprehensive assessment of the market and contains thoughtful insights, facts, historical data, and statistically supported and industry-validated market data. It also contains projections using a suitable set of assumptions and methodologies. The research report provides analysis and information according to market segments such as geographies, application, and industry.

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The regional analysis includes:

North America (U.S., Canada)

Latin America (Mexico. Brazil)

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Asia-Pacific (China, India, ASEAN, Australia & New Zealand)

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The report is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. The report provides in-depth analysis of parent market trends, macro-economic indicators and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographies.

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Strategies of key players and products offered

Potential and niche segments, geographical regions exhibiting promising growth

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Table of Contents Covered In this Market Report Are:

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Surge in the Adoption of Aesthetic Medicine And Cosmetic Surgery to Fuel the Growth of the Aesthetic Medicine And Cosmetic Surgery Market Through the...

COVID-19 case reclassified out of Medicine Hat zone, city down to 10 active cases – CHAT News Today

Posted on July 10, 2020 by Danzig

The South Zone recorded four additional cases over the past 24 hours. The total now stands at 1,385 1,283 recovered, 90 active and 12 deaths. Two people in the zone are in hospital, a drop of one.

Across Alberta, there are 37 new cases. There are 584 active cases, a decrease of 24, and 7,774 recovered cases, an increase of 58. The province now has 8,519 total cases.

There are 46 Albertans in hospital, seven of which are in ICU. The provincial death toll rose by three to 161.

There were 6,966 tests were completed in the past 24 hours.

Dr. Deena Hinshaw announced July 2 that she will not be providing daily updates this week but that the online numbers will be updated daily.

Cypress County has 30 total cases 21 recovered cases and nine active ones.

The County of Forty Mile has two active cases and three recovered.

The MD of Taber remains at 12 total cases, nine active and three recovered.

Special Areas No. 2 has no cases on the map. There was previously one recovered case and one death attributed to the region.

The County of Newell is showing one active case and 20 recovered. In Brooks, there remains one active case. There have been 1,119 total cases in the city and 1,109 are recovered. Brooks has recorded nine deaths.

The County of Warner has 41 total cases, 39 active, one recovered and one death.

The City of Lethbridge has a total of 49 cases. Of those, nine are listed as active and 40 recovered. Lethbridge County has five cases, two active cases and three recovered.

The figures on alberta.ca are up-to-date as of end of day July 8, 2020.

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COVID-19 case reclassified out of Medicine Hat zone, city down to 10 active cases - CHAT News Today

Donald Trump, President Winning-by-Losing, Is, in Fact, Losing – The New Yorker

Posted on July 10, 2020 by Danzig

Soon after the Supreme Court ruled, on Thursday morning, against Donald Trumps effort to stop a Manhattan prosecutor from obtaining his tax returns, the President lamented how unjust the decision was. Courts in the past have given broad deference, he tweeted. BUT NOT ME! He elaborated: This is all a political prosecution, he said. Not fair to this Presidency or Administration! POTUS is, as ever, a whiny loser.

His whinging, though, should not obscure the fact that Trump, yet again, has escaped to fight another day. In a 72 ruling, the Justices, including two Trump appointees, reaffirmed the principle that no one, not even the President, is above the law. But the decision allowed Trump to continue fighting in lower courts over the terms under which he must comply, a ruling that makes it all but certain that he will not have to turn over his tax returns before this falls Presidential election. He may lament PRESIDENTIAL HARASSMENT, but Trump seems to have once more managed to avoid having to produce information about his sketchy finances before facing voters. Losing just might be a form of winning after all. Sure enough, that was exactly what Trumps advisers took to claiming. This was a win for the President, the Administrations press secretary, Kayleigh McEnany, declared from the White House lectern. Asked about Trumps angry tweets, McEnany simply dismissed them as general comments. It is a big win, she added, before also saying, confusingly, that the President agreed with the dissenters in the case. I would underscore the victory here.

This is classic Trump Administration doublespeak. Reality is whatever the Trumpians say it is. The Supreme Court decision can be both terribly unfair and a great win. And why not? Trump has made a career of turning bad news into good, of rewriting bankruptcies and divorces and unfulfilled promises into spectacular accomplishments. After his Republican Party lost the House of Representatives, in 2018, Trump called the midterm-election results a Big Victory. After the special counsel Robert Mueller submitted a report, in 2019, documenting ten instances in which the President engaged in obstruction of justice, Trump called the report complete and total Vindication. But his problems now seem to be piling up, and I am not just referring to the question of when and how he will finally have to turn over his tax returns. As the coronavirus surges once again across America, polls show Trump losing more support by the day. This week, the nonpartisan Cook Political Report issued its July Electoral College ratings and determined that, as of right now, the Presidential election looks like a Democratic tsunami. Even the reliably pro-Trump polling agency Rasmussen registered the President at the lowest approval level of his tenure, with just thirty-nine-per-cent support. No wonder Trump is whining. He is always about ME! The question of the moment is this: With Americans suffering so deeply from the pandemic and the attendant economic crisis, and with a national election to decide his fate only a hundred and seventeen days away, can Trump pull off his most epic act of winning by losing yet?

In her scorching new book, Too Much and Never Enough: How My Family Created the Worlds Most Dangerous Man, Trumps niece Mary Trump portrays her Uncle Donald as an abusive narcissist with a rampant and undiagnosed antisocial personality disorder, and she blames many of his evident character flaws on his father, Fred, a sociopath who withheld love from his son when he needed it mostas a small child. It might seem contradictorybeyond even Trumps standardsto claim in the course of a few hours that the Supreme Court had been wildly unfair to him and had also handed him a significant victory. But his niece, who holds a doctorate in clinical psychology, shows that this has long been Trumps way. In the early nineteen-nineties, she notes, when his business was in increasingly serious trouble and banks were refusing to extend him any more credit, Trump found a long list of others to blame. Nothing was ever fair to him, she writes. At the same time, Trump had to please his father by continuing to portray himself as a wild success. The future Presidents demanding patriarch would not accept anything less. In the books particularly to-the-point conclusion, Mary Trump describes the toxic positivity that she says is his family legacy. The President, in other words, is simply incapable of accepting a harsh or unpleasant reality. He has no choice but to deny it. Losing is winning for him. It has to be.

This is also the strongly held view of various Trumpologists outside of his family, who have discerned in the Presidents biography a long history of being unable to deal with truly negative circumstances. He actually holds very few tools in his kit. Hes not equipped for compromise or changing direction. Indeed, he only knows how to move forward on the path he has determined, one of Trumps biographers, Michael DAntonio, told me. This is why he got into trouble with his bankruptcies way back whenhe failed to accept that he was a bad manager of complex organizations, and kept trying it until he was hemmed in by lenders who refused him further credit. Like Mary Trump, DAntonio said he believed that Trump is incapable of processing bad news and dealing with it. Letting in negative feedback is almost painful for him. In fact, it almost seems to me like he either cannot hear, or really hold in his mind, the bad news that he should receive and then let guide him in making adjustments, DAntonio told me.

The problem for Trump now is that, although his willful inversion of reality may work for him as a coping mechanism, it is wildly unsuited as a formula for governance, especially during a public-health crisis, when facts matter and spin is irrelevant. The coronavirus pandemic and the recession are the ultimate bad news for a President who cant bear it. On Wednesday, the German Chancellor, Angela Merkel, travelled to Brussels to speak to the European Parliamenther first appearance outside of Germany since the start of the pandemic. As always, she was understated but unyielding. You cannot fight the pandemic with lies and disinformation, she said. Here in Washington, where the grim march of the coronavirus is unrelenting, it sounded like a message aimed right at the man in the White House.

But President Losing-Is-Winning has an increasingly inarguable set of facts to wrestle with. The U.S. has repeatedly set records for new cases in recent days. The spike is sharp, and it is broad: the numbers are now going up in thirty-three states. In some, the pandemic is spreading at an alarming rate: a rise of thirty-eight per cent in new cases in California this week, twenty-eight per cent in Texas, twenty-five per cent in Florida. With more than a hundred and thirty thousand Americans already dead, a new projection this week suggests that more than two hundred thousand Americans will die of the coronavirus by November. Even a graphic on the Trump-friendly Fox News on Thursday was devastating. It showed total cases, total deaths, and new cases. Underneath the first two numbers was the phrase Most in the World.

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Donald Trump, President Winning-by-Losing, Is, in Fact, Losing - The New Yorker

A guided tour into the troubled mind of Donald Trump – Newsday

Posted on July 10, 2020 by Danzig

Mary Trump, a trained clinical psychologist and the niece of the president of the United States, knows of what she speaks.

"It's difficult to understand what goes on in any family perhaps hardest of all for the people in it. Regardless of how a parent treats a child, it's almost impossible for that child to believe that parent means them any harm," she observes in her new book, "Too Much and Never Enough," as she parses the legacy of the patriarch, Fred Trump Sr. "Abuse can be quiet and insidious just as often as, or even more often than, it is loud and violent. As far as I know, my grandfather wasn't a physically violent man or even a particularly angry one. He didn't have to be; he expected to get what he wanted and almost always did."

Mary's father, Fred Trump Jr., was crushed by those expectations and by his struggle with alcoholism, which she lays out in harrowing and courageous detail. (As a child, she once encountered her father laughing while aiming a shotgun at her mother's face, for example.) Fred Jr.'s demise is a key narrative arc of the book, but the two people who loom largest over the entire affair are Fred Sr. and one of his other sons, Donald both of whom she describes as deeply intertwined, driven and disturbed.

"Financial worth was the same as self-worth, monetary value was human value," Mary writes. "The more Fred Trump had, the better he was. If he gave something to someone else, that person would be worth more and he less. He would pass the attitude on to Donald in spades."

In a book filled with firsthand accounts of dysfunctional family gatherings, references to decades of unsettling reporting about the Trumps, documentation of financial grifting, and many episodes of parents and siblings jousting with one another over money, egos and abandonment, Mary draws a portrait of a surreal, scarred clan that might have been forgotten had one of its members not found his way into the White House. But the fact that Donald morphed from huckster to celebrity to president makes her account seminal and indispensable.

Mary's clarity, training, discipline and sharp eye help make her a reliable narrator, and she's a fluid, witty writer to boot. Much of what's she's written about I've covered as a journalist and an author (Donald unsuccessfully sued me for libel for my 2005 biography, TrumpNation). Everything in her book that I'm familiar with is spot on. There is plenty in the book, however, that I wasn't aware of, and I suspect that's the reason the president and his siblings have gone to court to try to halt its publication. The Trumps know that Mary's understanding of her family is authentic she's a true insider in an era when "insider" accounts of the president are a dime-a-dozen and that what she's written is likely to be indelible.

The subtitle of Mary's book is "How My Family Created the World's Most Dangerous Man," and she makes her case diligently and chronologically. Fred Sr. was steely and unforgiving, while his wife, Mary, lived in his shadow, emotionally distant and demanding. The Queens mansion where Donald grew up as his father's favorite is an intimidating pile that Mary calls The House. In the basement of The House, Fred Sr., a teetotaler, kept an elegant bar outfitted with everything but alcohol and guarded by a collection of life-sized wooden statues of Native American chiefs standing along a wall. An oil painting of a lovely Black nightclub singer with "generous swaying hips" backed by a Black jazz band hung on a wall nearby. That was apparently as close as Fred Sr. wanted Black people to get to his family. The son of a German immigrant, he slurred any person of color seeking to rent an apartment from him as "die Schwarze." Roy Cohn, the infamous lawyer and mob confidante, came into the Trumps' lives when Fred Sr. and Donald retained him to battle a Justice Department probe of racial discrimination at Trump properties in the 1970s.

Fred Sr. ruled the roost, and in Mary's view he did so as a sociopath, driving her father to ruin and forcing her Uncle Donald to adapt to his binary, winner-take-all view of the world. Losing was unacceptable, and the power of positive thinking was everything. "Just give it a quarter of a turn on the mental carburetor," Fred Sr. advised Fred Jr. as the way to conquer alcoholism. Mary writes that after Fred Jr. died, the Trumps apparently schemed to disinherit her and her brother, cutting off their health insurance when they wouldn't play along.

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Donald, more than any of his four siblings, reveled in Fred Sr.'s hothouse. He stole one of his brother's trucks as a child just so he could see how anguished his brother might become. He bucked authority as a teenager, prompting his parents to send him to military school. According to Mary, he paid someone to take the SAT exams for him so he could get into a better college. When Fred Sr. slipped into dementia soon before dying, Donald, strapped for cash, maneuvered unsuccessfully to push his siblings aside and gain control of an estate worth several hundred million dollars. Although Donald's entire career was built on Fred Sr.'s wealth and connections, Donald treated his father dismissively in his final years. Then again, Fred Sr. treated most people dismissively, and Donald is what Mary describes as a "Frankenstein's monster," shaped by his father's pathologies.

Fred Sr. lacked the marketing savvy and media know-how of his son, so he helped push Donald into the spotlight and risked the family fortune along the way so he could bask in his son's glory. Donald thrived on the attention and took advantage of the license afforded by his father's wealth, eventually adopting "cheating as a way of life." Mary takes the media to task for searching for a "strategy" in anything Donald does and for soft-pedaling what she describes as multiple psychological disorders, which, by her account, check a variety of boxes in diagnostic manuals. She thinks that Donald, at a minimum, suffers from an "antisocial personality disorder" and a longstanding but undiagnosed learning disability.

"The fact is, Donald's pathologies are so complex and his behaviors so often inexplicable that coming up with an accurate and comprehensive diagnosis would require a full battery of psychological and neuropsychological tests that he'll never sit for," she writes.

Mary's understanding of her family was also shaped by reporting in the New York Times. A landmark expose the Times published in 2018 about the Trump family's tax dodging and financial chicanery relied on her as a key source. She provided the paper with pivotal documentation that showed how the Trumps used a shell company to skim millions from the family business to avoid estate and income taxes. It was the Times's forensic work, using her documentation, that revealed the skimming to her and to readers and also made her realize that her aunts and uncles had most likely been cheating her out of significant sums of money as well.

For all of that, the tone of Mary's book isn't bitter. She maintains a sense of humor about some of the absurdities she's encountered (Donald was slow to pay her when she helped ghostwrite one of his books) and is forgiving, to a point, about the myriad shortcomings of her various relatives. But she is clearly disappointed. The book is ultimately a melancholy account of aunts and uncles who openly disdain Donald but are afraid to get in his way. The book quotes Donald's eldest sister, Maryanne, a former federal judge, saying that Donald "has no principles. None!" Maryanne is also quoted dismissing the possibility that her brother will be elected president: "He's a clown this will never happen." The fact that Donald was elected also informs the book's melancholy, with Mary stunned that tens of millions of voters were capable of embracing or overlooking her uncle's "blatant racism" and his "casual dehumanization of people."

Other observers have picked up on some of this over the years, of course. Liz Smith, the late New York gossip columnist, had a street-smart understanding of Trump. "There's something about him that's ever juvenile. It's hard to believe he's a grown-up person who went to college," she once told me. "He's like a kid, and he's got that brash, narcissistic thing that works for him. He has enormous appeal to the masses because of that."

But Mary understands that's not a benign matter anymore. "Donald today is much as he was at three years old: incapable of growing, learning or evolving, unable to regulate his emotions, moderate his responses, or take in and synthesize information," she writes. "This is far beyond garden-variety narcissism; Donald is not simply weak, his ego is a fragile thing that must be bolstered every moment because he knows deep down that he is nothing of what he claims to be. He knows he has never been loved."

Writ large on an international stage amid a pandemic and social upheaval, and with the powers of the presidency at Donald's disposal those resentments metastasize into something wildly menacing.

"He has suffered mightily," Mary writes of Donald's worldview, "and if you aren't doing all you can to alleviate that suffering, you should suffer too."

Timothy L. O'Brien is a senior columnist for Bloomberg Opinion.

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A guided tour into the troubled mind of Donald Trump - Newsday

JOHN KRULL: The Constitution, not Trump, protects images of Jesus – Goshen News

Posted on July 10, 2020 by Danzig

Even in an insane time, some bits of idiocy are too great to endure.

Take the debate about whether statues of Jesus will be pulled down amidst the current furor over whether monuments to Confederates and slaveholders should continue to stand.

A few days ago, President Donald Trump said the push to remove marble tributes to Jefferson Davis, Robert E. Lee and other historical figures who either took up arms against the United States or held human beings in bondage also could threaten similar representations of Abraham Lincoln and, yes, Jesus.

Trump vowed that never would happen.

Give me break.

Lincoln is a secular historical figure and public decisions about whether to honor or not honor him are just that public decisions. They can be voted on, up or down, just as questions about whether Barack Obama, George W. Bush or Donald Trump should be similarly honored can be.

Jesus is another matter altogether.

Likenesses of Jesus accurate or not cannot and will not be erected or torn down by a vote of the citizenry or through public pressure.

This isnt because the thrice-married Donald Trump, odd defender of supposed traditional values, will man the barricades and fight back the infidels.

No, its because of the U.S. Constitution a document this president really ought to get around to reading someday.

There shouldnt be any statues, busts or other representations of Jesus placed on public property at taxpayer expense in the first place unless, of course, the same tributes are open to and offered to all other faith traditions. The establishment clause of the First Amendment prevents government from endorsing any religion.

Statues of Jesus on private property, on the other hand, cant be touched by public pressure or majority vote. The free exercise clause of that same First Amendment prevents government the instrument of majority opinion from interfering with individual religious expression.

Those clauses in the Constitution exist because the founders wanted to make faith a private, individual matter. We dont get to take votes on whether our neighbor should be a Baptist, a Muslim or an atheist. Such questions are left up to our neighbor. Questions of conscience are her choice and her responsibility.

Not ours.

The right isnt absolute. No right is.

We dont have a First Amendment defense that would allow us to claim that a divine power urged us to shoot up a fast food restaurant or a nightclub and thus get away with murder. Nor can we rob banks and argue that were merely confronting the money changers.

But all reasonable individual expressions of faith including displaying statues or paintings of Jesus Christ are protected.

And, unless the First Amendment is repealed, those expressions of faith always will be.

Its possible Donald Trump does not understand this. The list of things this president does not know is long enough to be considered almost endless.

But, even if thats the case, its irresponsible for him to suggest that statues of Jesus somehow are imperiled for at least two reasons.

The first is that this national debate about how we should view the most painful parts of our countrys past is going to be agonizing enough as it is.

Make no mistake about this. The discussions millions of Americans are having right now about how we should regard the Civil War and our tortured history regarding race probe this nations deepest and most enduring wounds.

To have a president who refuses to be part of the healing process is bad enough.

To have one who insists on deepening those wounds is even worse.

Much worse.

The second reason Trump is irresponsible is that hes misleading Americans about their rights rights hes duty-bound as president to defend.

The fact that he may not understand those rights himself is no excuse.

Hes the president.

He should know his duty.

Even in an insane time, some bits of idiocy should not be tolerated.

This is one of them.

We are making critical coverage of the coronavirus available for free. Please consider subscribing so we can continue to bring you the latest news and information on this developing story.

John Krull is director of Franklin Colleges Pulliam School of Journalism and publisher of TheStatehouseFile.com, a news website powered by Franklin College journalism students.

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JOHN KRULL: The Constitution, not Trump, protects images of Jesus - Goshen News

The 12 Best Zombie Movies of All Time – Men’s Health

Posted on July 10, 2020 by Danzig

Columbia/Sony/Hulu

Zombie movies have been an important part of the horror field for a very long time, but the sub-genre has expanded to include picks that are comedic, action-heavy, and even romantic.

But if you're wondering just why people find zombie movies so fascinating, Stanford literary scholar Angela Becerra Vidergar once explained that, "We use fictional narratives not only to emotionally cope with the possibility of impending doom, but even more importantly perhaps to work through the ethical and philosophical frameworks that were in many ways left shattered in the wake of WWII [when the genre became popular]...In a way, survivalism has become a dominant mode of self-reference for a greater number of people. You see that in the obsession in apocalypse and disaster in the fictional stories we tell."

And while the current coronavirus pandemic has led many people to reach for happier, lighter movies to watch, there's also a good reason why you're reaching for your favorite post-apocalyptic flick: "There is this glimmer of hope that I am really interested in," Vidergar explains. "Even if as a society we have lost a lot of our belief in a positive future and instead have more of an idea of a disaster to come, we still think that we are survivors, we still want to believe that we would survive."

So if you're looking for a new zombie flick to watch, we have some picks for youhere are the 12 best zombie movies of all time.

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1Train to Busan

This South Korean film takes place on a train to Busan as a zombie apocalypse suddenly breaks out both in the country on the train, and the passengers have to figure out how to stay alive while also trying to find a safe station to stop the train. The movie's sequel, Peninsula, will be released this year.

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2World War Z

World War Z's power is in its realism, and the zombie outbreak is portrayed in locales worldwide from Newark, New Jersey to Cardiff, Wales. However, Brad Pitt is there to save the day as United Nations investigator Gerry Lane.

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3Zombieland

Woody Harrelson, Jesse Eisenberg, Emma Stone, and Abigail Breslin star in this comedic zombie tale about a group of survivors that try to find a sanctuary free from the zombies ravaging the nation. Expect funny gags, lots of zombie killings, and a cameo from a beloved actorand if you need even more zombie in your life, check out the sequel Zombieland: Double Tap.

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4Little Monsters

What do you get when you mix together Academy Award winner Lupita Nyong'o, a bunch of kindergarteners, and a sudden outbreak of zombies? Movie magic!

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5Dawn of the Dead

The classic 1978 film is the second entry in George A. Romero's Night of the Living Dead series, and it follows a group of survivors as they barricade themselves inside a suburban shopping mall amidst a zombie outbreak. Unfortunately, the 70's version isn't available for streaming online but you can also check out the 2004 remake.

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628 Days Later

This film was ranked on the top 100 list of the best British films ever, and it follows a group of four survivors as they struggle to cope with their new reality after a zombie outbreak starts when a group of animal activists release a chimpanzee infected a contagious rabies-like virus. It was later followed by a sequel titled 28 Weeks Later.

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7Warm Bodies

Warm Bodies will truly make you believe that you can find love anywhereeven in the middle of a post-apocalyptic zombie-infested world.

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8Shaun of the Dead

This film is definitely for viewers that like some laughs with their zombie flicks, and Shaun of the Dead includes references to Night of the Living Dead, Dawn of the Dead, and 28 Days Later.

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9The Cabin in the Woods

This movies follows a group of college kids (including Chris Hemsworth and Jesse Williams) as they spend a weekend in a remote forest cabin. What they don't know is that engineers are remotely controlling the cabin from a secret lab, and they soon fall victim to the zombies surrounding the property.

10Resident Evil

Based on the video game franchise of the same name, Resident Evil films follow former security specialist and covert operative Alice (Milla Jovovich) as she fights against the Umbrella Corporation, whose powerful bioweapons have triggered a zombie apocalypse. Fun factThe Resident Evil film series has grossed over $1 billion worldwide, making it the highest-grossing film series based on a video game.

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11The Dead Don't Die

Hold on, we need this movie's extremely stacked cast first: Bill Murray, Adam Driver, Tilda Swinton, Chlo Sevigny, Steve Buscemi, Danny Glover, Caleb Landry Jones, Rosie Perez, Iggy Pop, Sara Driver, RZA, Selena Gomez, Austin Butler, Tom Waits, and Carol Kane. Whew. The Dead Don't Die follows a small town's police force as they combat a sudden zombie invasion.

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12I Am Legend

While some say I Am Legend isn't a zombie film, there are plenty of fans of this Will Smith-helmed flick that believe its part of the genre. Based on Richard Matheson's 1954 novel I Am Legend, Smith plays a US Army virologist that's the last human in NYC after a virus which was originally created to cure cancer wipes out most of mankind.

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The 12 Best Zombie Movies of All Time - Men's Health

Global wildlife surveillance could provide early warning for next pandemic – Washington University School of Medicine in St. Louis

Posted on July 10, 2020 by Danzig

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Experts propose decentralized system to monitor wildlife markets, other hotspots

A juvenile saddleback tamarin is measured as part of an annual health check of a population of three primate species in southeastern Peru. In a perspective article published July 9 in Science, a team of wildlife biologists, infectious disease experts, and others propose a decentralized, global wildlife biosurveillance system to identify before the next pandemic emerges animal viruses that have the potential to cause human disease.

The virus that causes COVID-19 probably originated in wild bats that live in caves around Wuhan, China, and may have been passed to a second animal species before infecting people, according to the World Health Organization. Many of the most devastating epidemics of recent decades including Ebola, avian influenza and HIV/AIDS were triggered by animal viruses that spilled over into people. Despite the ever-present danger of a new virus emerging and sparking a worldwide pandemic, there is no global system to screen for viruses in wild animals that eventually may jump to humans.

In a perspective article published July 9 in Science, a diverse group of infectious disease experts, ecologists, wildlife biologists and other experts argue that a decentralized global system of wildlife surveillance could and must be established to identify viruses in wild animals that have the potential to infect and sicken people before another pandemic begins.

Its impossible to know how often animal viruses spill over into the human population, but coronaviruses alone have caused outbreaks in people three times in the last 20 years, said co-author Jennifer A. Philips, MD, PhD, referring to the SARS, MERS and COVID-19 epidemics. Philips is an associate professor of medicine and co-director of theDivision of Infectious Diseasesat Washington University School of Medicine in St. Louis. Even a decade ago it would have been difficult to conduct worldwide surveillance at the human-wildlife interface. But because of technological advances, it is now feasible and affordable, and it has never been more obvious how necessary it is.

Every animal has its own set of viruses, with some overlap across species. Often, an animal species and its viruses have lived together for so long that theyve adapted to one another, and the viruses cause either no symptoms or only mild to moderate disease. But when different animal species that dont normally have much contact are brought together, viruses have the opportunity to jump from one species to another. Most viruses dont have the genetic tools to infect another species. But viruses with such tools can be lethal to a newly infected species with no natural immunity.

Human activity is making such spillover events more and more likely. As the population of the world continues to grow, the demand for natural resources skyrockets. People push into wild areas to make space for new homes and businesses, and to access resources to fuel their economies and lifestyles. Wild animals are caught and sold for consumption, or as exotic pets at wildlife markets, where diverse species are jumbled together under crowded and unsanitary conditions. Wild-animal parts are shipped around the world as trinkets or ingredients for traditional or alternative medicines.

And yet there is no international system set up to screen for disease-causing viruses associated with the movement of wildlife or wildlife products.

In the lead up to this article, I spoke with friends and colleagues around the world who do wildlife research in Madagascar, Indonesia, Peru, Ecuador and asked them, Where do you take your samples for screening? said co-author Gideon Erkenswick, PhD, a postdoctoral research associate in Philips lab. Erkenswick is also the director of Field Projects International, a nonprofit organization dedicated to the study and conservation of tropical ecosystems. In almost every situation, the answer was Nowhere. Locally, there is nobody with dedicated time and resources to do this work. To find new disease-causing viruses, we have to find willing foreign collaborators, then get samples out of the country, which is difficult and expensive.

Philips, Erkenswick, and colleagues in the Wildlife Disease Surveillance Focus Group that authored the Science paper, suggest the establishment of a global surveillance network to screen wild animals and their products at hotspots such as wildlife markets. The idea would be to have local teams of researchers and technicians extract viral genomes from animal samples, rapidly sequence them on site and upload the sequences to a central database in the cloud. The cost and size of the necessary scientific equipment has dropped in recent years, making such screening affordable even in resource-limited settings where most such hotspots are located.

Theres now a genetic sequencer available that is literally the size of a USB stick, Erkenswick said. You could bring that and a few other supplies into a rainforest and analyze a sample for sequences associated with disease-causing viruses on site in a matter of hours. I mean, if you do chance upon something like the virus that causes COVID-19, do you really want to be collecting it, storing it, transporting it, risking further exposure, sample degradation, and adding months or years of delay, before you figure out what youve got? There are people with the expertise and skills to do this kind of work safely pretty much everywhere in the world, they just havent been given the tools.

Once viral sequences are uploaded, researchers around the world could help analyze them to identify animal viruses that may be a threat to people and to develop a better understanding of the universe of viruses that thrive in different environments. By comparing genomic sequence data, researchers can identify what family an unknown virus belongs to and how closely it is related to any disease-causing viruses. They can also identify whether a virus carries genes associated with the ability to cause disease in people.

By knowing the diversity out there, and tracking its evolution, we can ensure that we stay ahead of whats in wildlife populations and at the wildlife-human interface, Philips said. In the past, before modern transportation, spillover events would have been local and spread slowly, giving people elsewhere time to respond. But now the world is so small that an event in one place puts the whole world at risk. This is not someone elses problem. Its everyones problem.

Watsa M and the Wildlife Disease Surveillance Focus Group. Rigorous wildlife disease surveillance: A decentralized model could address global health risks associated with wildlife exploitation. Science. July 10, 2020. DOI: 10.1126/science.abc0017

Washington University School of Medicines 1,500 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Childrens hospitals. The School of Medicine is a leader in medical research, teaching and patient care, ranking among the top 10 medical schools in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked to BJC HealthCare.

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Bennett named chief of breast imaging section – Washington University School of Medicine in St. Louis

Posted on July 10, 2020 by Danzig

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Radiologist also will lead clinical services

Radiologist Debbie Lee Bennett, MD, has been named chief of the breast imaging section at Washington University School of Medicine in St. Louis.

After a national search, noted radiologist Debbie Lee Bennett, MD, has been named chief of breast imaging forMallinckrodt Institute of Radiology(MIR) at Washington University School of Medicine in St. Louis.

Bennett will oversee screening and diagnostic mammography services offered throughSiteman Cancer CenteratBarnes-Jewish Hospitaland Washington University School of Medicine, including at the Joanne Knight Breast Health Center.

Bennett comes to the university from Saint Louis University School of Medicine, where she had served on the faculty since 2014, most recently as an associate professor. There, she established the breast imaging section and began serving as its chief in 2015.

We are very excited that someone with Dr. Bennetts proven leadership and experience is joining our breast imaging faculty, said Richard L. Wahl, MD, the Elizabeth Mallinckrodt Professor of Radiology, head of the radiology department at the School of Medicine and director of MIR. She also is a welcome addition to our team of clinical experts, whose skill and experience make a difference in the lives of our patients.

Bennett serves on several committees of professional and academic organizations, including the American College of Radiology, Society of Breast Imaging, American Board of Radiology and Radiological Society of North America. She also is engaged in outreach and education, and has mentored many residents who have gone on to pursue careers in breast imaging.

After an internship in internal medicine at Vanderbilt University Medical Center, she completed a residency in diagnostic radiology and a fellowship in breast imaging, both at Massachusetts General Hospital.

She earned her medical degree from Harvard Medical School and bachelors degree from Princeton University, graduating magna cum laude from both institutions.

Washington University School of Medicines 1,500 faculty physicians also are the medical staff ofBarnes-JewishandSt. Louis Childrenshospitals. The School of Medicine is a leader in medical research, teaching and patient care, ranking among the top 10 medical schools in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked toBJC HealthCare.

Siteman Cancer Center, ranked among the top cancer treatment centers by U.S. News & World Report, also is one of only a few cancer centers to receive the highest rating of the National Cancer Institute (NCI) exceptional. Comprising the cancer research, prevention and treatment programs ofBarnes-Jewish HospitalandWashington University School of Medicinein St. Louis, Siteman treats adults at six locations and partners withSt. Louis Childrens Hospitalin the treatment of pediatric patients. Siteman is Missouris only NCI-designated Comprehensive Cancer Center and the states only member of the National Comprehensive Cancer Network. Through theSiteman Cancer Network, Siteman Cancer Center works with regional medical centers to improve the health and well-being of people and communities by expanding access to cancer prevention and control strategies, clinical studies and genomic and genetic testing, all aimed at reducing the burden of cancer.

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Bennett named chief of breast imaging section - Washington University School of Medicine in St. Louis

Edgewise Therapeutics Appoints Abby H. Bronson, M.B.A., as Vice President, Patient Advocacy and External Innovation – Business Wire

Posted on July 10, 2020 by Danzig

BOULDER, Colo.--(BUSINESS WIRE)--Edgewise Therapeutics, a biopharmaceutical company developing small molecule therapies for musculoskeletal diseases, today announced the appointment of Abby H. Bronson to the newly created position of Vice President, Patient Advocacy and External Innovation. Ms. Bronson will be responsible for leading patient advocacy and building key external relationships with the muscular dystrophy community with the goal of bringing patient insights into drug development. This comes at an important time as Edgewise prepares EDG-5506, the companys lead product candidate, for clinical development for Duchenne and Becker muscular dystrophy (DMD and BMD). Ms. Bronson brings a wealth of experience in the rare disease space, most recently serving as Senior Vice President of Research Strategy at Parent Project Muscular Dystrophy (PPMD), the largest patient centered advocacy organization devoted to finding a cure for Duchenne.

We are pleased to have Abby join our company as we advance our muscular dystrophy program and prepare EDG-5506 for clinical development, said Kevin Koch, Ph.D., President and Chief Executive Officer, Edgewise Therapeutics. Having a strong patient advocacy perspective and voice in the DMD community is integral to executing against our vision of creating novel drugs that will transform the lives of patients living with severe musculoskeletal diseases. Abby brings an extensive patient advocacy background and we are fortunate to have someone with her knowledge and passion for the patient community join our team.

Im excited to join the dedicated team at Edgewise and to support the advancement of EDG-5506, a potentially transformative product candidate in DMD, through meaningful engagement with the patient and scientific communities, said Ms. Bronson.

Ms. Bronson is a leader within the rare disease space and over her career has managed critical alliances and partnerships with academia, biopharmaceutical companies, National Institutes of Health (NIH)/federal programs, patient groups and other stakeholders. Most recently she worked at PPMD as Senior Vice President of Research Strategy where she led the Research Portfolio and built strong relationships with Duchenne academic and clinical researchers, industry and regulators to help incorporate the patient voice and improve drug development success in DMD. Prior to this, Ms. Bronson was at the NIHs Center for Advancing Translational Sciences, Division of Clinical Innovation where she was Director of Operations for the Clinical and Translational Science Awards Program. Additionally, Ms. Bronson held positions at Children's National Medical Center, where she managed the global development and execution of key translational and drug development initiatives in select rare diseases, focusing on Duchenne at the Research Center for Genetic Medicine; MedImmune (acquired by Astra-Zeneca), where she led marketing initiatives for Synagis (palivizumab) for RSV disease; Medtronic where she managed global product marketing for select medical devices; and Ciba-Geneva Pharmaceuticals (acquired by Novartis) where she was responsible for managing relationships with major managed care organizations and led sales and marketing initiatives for their cardiovascular franchise. Ms. Bronson received her M.B.A from The Wharton School, University of Pennsylvania and B.A. degree from the University of Vermont.

About Muscular Dystrophy

Muscular dystrophies are a group of genetic disorders associated with defects in the critical muscle-associated structural protein dystrophin or the sarcomere complex and are characterized by progressive muscle degeneration and weakness. In individuals with neuromuscular conditions such as Duchenne muscular dystrophy, muscle contractions lead to continued rounds of muscle breakdown that the body struggles to repair. Eventually, as patients age, fibrosis and fatty tissue accumulate in the muscle portending a steep decline in physical function that ends with mortality. There remains an unmet need for treatments that reduce muscle breakdown in patients with neuromuscular conditions. Arresting this amplified muscle response will have a dramatic effect on disease progression.

About Edgewise Therapeutics

Edgewise Therapeutics, founded in 2017 by Alan Russell, Ph.D., Peter Thompson, M.D. (Orbimed Advisors) and Badreddin Edris, Ph.D., (Springworks Inc.), is pioneering the development of first-in-class medicines for the treatment of high morbidity musculoskeletal diseases. Skeletal muscle is the largest organ system in the human body, regulating both force production to enable muscle contraction, locomotion, and postural maintenance and the metabolism of glucose, fatty and amino acids. By modulating these processes in skeletal muscle, we create therapeutic agents that will reduce muscle damage, normalize muscle function, decrease mortality and profoundly benefit our patients quality of life. To learn more, go to: http://www.edgewisetx.com

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Edgewise Therapeutics Appoints Abby H. Bronson, M.B.A., as Vice President, Patient Advocacy and External Innovation - Business Wire

Search for cure for common parasitic infection focus of $5.5 million NIH grant – Washington University School of Medicine in St. Louis

Posted on July 10, 2020 by Danzig

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Toxoplasma infection affects about 2 billion people globally

Parasitologist L. David Sibley, PhD (standing), the Alan A. and Edith L. Wolff Distinguished Professor of Molecular Microbiology at Washington University School of Medicine in St. Louis, talks with postdoctoral researcher Alex Rozenberg, PhD, (left) and staff scientist Joshua Radke, MD. The three are part of an international effort led by Sibley to find drugs to cure toxoplasmosis, a parasitic disease characterized by vision problems and brain complications.

L. David Sibley, PhD, the Alan A. and Edith L. Wolff Distinguished Professor of Molecular Microbiology at Washington University School of Medicine in St. Louis, has spent decades unraveling the secrets of Toxoplasma gondii, a parasite spread by cats and contaminated water and food. People infected with Toxoplasma can generally control the infection, but the parasite remains in their bodies for life and can reactivate to cause toxoplasmosis, a disease characterized by vision problems and life-threatening complications in the brain.

Sibleys discoveries have put him at the forefront of the field of parasite biology. A few years ago, he was busy fielding interview requests from journalists about his latest high-profile paper when he opened an email from a woman in Heidelberg, Germany.

I would like to ask you, wrote the woman, after explaining that her husband was dying of toxoplasmosis, how far (near?) is the possibility of human therapy based on your work?

To Sibley, the email was a wake-up call.

We always say that we do basic science so that one day there might be an improvement in human health, but we dont always push hard enough to convert our discoveries into benefits for patients, Sibley said. After thinking hard about this issue, my colleagues and I came up with the idea of trying to find chemical compounds that eliminate the chronic stages of the parasite, rather than just control it, like current drug therapies do. We know a lot about the biology of this parasite. My lab has spent 30 years figuring out all the tricks the parasite uses to block the immune system. We have developed sophisticated genetic tools and animal models to monitor infection. All this has led to a pile of high-profile papers, and recognition, but has not really had an impact on people who suffer from this infection. I thought, Why not see if we can identify small molecules that might lead to a curative drug?

That plaintive email eventually led Sibley and colleagues at the California Institute for Biomedical Research (Calibr) in La Jolla, Calif.; the Broad Institute in Cambridge, Mass.; and the International Centre for Genetic Engineering and Biotechnology in New Delhi, India to launch an effort to identify chemical compounds that eliminate the chronic stages of Toxoplasma and have the potential to be developed into drugs to eradicate the infection. As principal investigator, Sibley has received a $5.5 million grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) to support the research.

Toxoplasma is a parasite that naturally cycles between mice and cats. An infected cat excretes millions of the parasite in its feces in a form known as oocysts, contaminating the soil and water. A mouse gets infected by eating food such as fruit or seeds contaminated with oocysts, and a cat eats the mouse, completing the cycle.

Humans and other animals are accidental participants in this process. Herbivorous animals like cows and sheep can become infected as they graze. People become infected by eating undercooked meat from such animals or unwashed vegetables, or by drinking contaminated water. Some people become infected by failing to wash their hands after cleaning cats litter boxes. Once inside a persons digestive tract, the parasite emerges from the cyst, burrows through the intestinal wall and spreads to the muscle, heart, brain and eyes. There, it develops into a cyst form and remains for the rest of the persons life.

About a quarter of the worlds population is thought to be infected with Toxoplasma. Most people do not have symptoms because a healthy immune system keeps the parasite in check. In people with compromised immune systems, though, the parasites do not stay in their cysts and instead begin to multiply, causing debilitating, sometimes fatal, damage to the brain, eyes and other organs. Women who become infected during pregnancy may pass the infection to their fetuses, resulting in severe birth defects.

Drugs for toxoplasmosis only target the parasite in the active phase, leaving cysts untouched. Since parasites may emerge from the cysts at unpredictable times, people must continue taking the drugs for prolonged periods, sometimes more than a year. Even so, the risk of relapse is high. Supplementing current therapies with a drug that eliminates the cysts not only would speed up treatment, it would cure the infection.

Nobodys ever really looked for drugs that target the latent, cyst phase, Sibley said. You cant just take drugs that work against other microbial infections and repurpose them. Thats been tried and it doesnt work very well. Its hard to kill the cyst form. Thats why they form cysts: to protect themselves when they are in an inhospitable environment. Were going to have to really dig into the biology and thats difficult and takes time. Since the potential monetary payoff will likely be small, big pharma just isnt interested. If potential drugs are going to be found, they will have to be started by academic labs.

The research project is already underway. A group led by Stuart Schreiber, PhD, a chemical biologist at the Broad Institute, screened some 80,000 small molecules for their ability to inhibit parasite growth and identified several promising leads. A group of structural biologists at the International Centre for Genetic Engineering and Biotechnology led by Amit Sharma, PhD, is analyzing how the initial leads interact with their target enzyme. A detailed understanding of the molecular structure will inform efforts to optimize the compounds. Medicinal chemist Arnab Kumar Chatterjee, PhD, leads a group at Calibr that is creating new molecules based on the promising leads but with improved potency, safety, bioavailability and other features. And Sibleys lab at the School of Medicine is responsible for the biological testing, making sure the team stays focused on compounds that actually have the capacity to treat the cyst stage.

The compounds weve started working on may not ultimately lead to a drug that works, Sibley said. There are no guarantees in this kind of work. But I think what we can do is establish a path forward. We can identify appropriate targets, establish the potency, and define the safety profile that youd need for an effective clinical candidate. Then, maybe more people will pick up on our leads and do the very difficult work that is necessary to get drug candidates evaluated in humans and get one of those candidates approved as a medicine, so people dont have to suffer and die from this devastating illness.

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Search for cure for common parasitic infection focus of $5.5 million NIH grant - Washington University School of Medicine in St. Louis

Stoke Therapeutics Announces Publication of Data in the Journal Nature Communications That Support the Company’s Proprietary Approach to Addressing…

Posted on July 10, 2020 by Danzig

BEDFORD, Mass.--(BUSINESS WIRE)--Stoke Therapeutics, Inc. (Nasdaq: STOK), a biotechnology company pioneering a new way to treat the underlying cause of severe genetic diseases, today announced the publication of data in the journal Nature Communications that support the companys proprietary approach to precisely upregulate protein expression using TANGO (Targeted Augmentation of Nuclear Gene Output) antisense oligonucleotides (ASOs).

Stoke was founded on the idea that we could use unique insights in RNA biology to do something that has never been done before, said Isabel Aznarez, Ph.D., Co-Founder and Vice President, Head of Biology of Stoke Therapeutics and the corresponding author on the paper. Rather than address genetic diseases by replacing, repairing or editing faulty genes, we set out to increase or stoke protein output from healthy genes. These data show that we can increase full-length, fully functional protein expression from a variety of healthy genes, which supports our hypothesis and may lead to a new way of treating severe genetic diseases.

To evaluate the approach broadly, Stoke selected four gene targets that vary in type and abundance of non-productive splicing events, gene size and protein function: PCCA (propionic acidemia); SYNGAP1 (autosomal dominant mental retardation 5); CD274 (autoimmune diseases, including uveitis); and SCN1A (Dravet syndrome). Stoke designed TANGO ASOs to target the non-productive splicing events in these genes and their activity was evaluated. Dose-dependent reductions of non-productive mRNA were observed to lead to increases in both productive mRNA and protein levels for each of the target genes.

More than 10,000 genetic diseases are caused by mutations in a single gene, however, current therapeutic approaches address as few as 5% of these diseases. In the experiments published today, a proprietary bioinformatics analysis of RNA sequencing datasets was used to identify a variety of non-productive alternative-splicing events that lead to mRNA degradation and limit protein production. Stoke found 7,757 unique genes that contained at least one non-productive event, of which 16% (1,246) were associated with causing a specific disease.

A link to the publication, Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression, can be found here: https://www.nature.com/articles/s41467-020-17093-9

Pre-mRNA Splicing and TANGO

Human cells naturally regulate protein production to maintain health. Pre-mRNA splicing, including alternative splicing, is an important mechanism used to regulate how much protein and which protein variant is produced. During splicing, introns are removed and exons are joined together to generate the mRNA template that carries the code to synthesize proteins. More than one third of alternative splicing events in mammals do not produce functional proteins and lead to mRNA degradation through nonsense-mediated mRNA decay (NMD). TANGO ASOs act at the pre-mRNA level and prevent non-productive alternative splicing so that the body produces more protein-coding mRNA and thus more protein. This approach is particularly applicable to diseases that are caused by insufficient protein production.

About Stoke Therapeutics

Stoke Therapeutics, Inc. (Nasdaq: STOK), is a biotechnology company pioneering a new way to treat the underlying causes of severe genetic diseases by precisely upregulating protein expression to restore target proteins to near normal levels. Stoke aims to develop the first precision medicine platform to target the underlying cause of a broad spectrum of genetic diseases in which the patient has one healthy copy of a gene and one mutated copy that fails to produce a protein essential to health. These diseases, in which loss of approximately 50% of normal protein expression causes disease, are called autosomal dominant haploinsufficiencies. The companys lead investigational new medicine is STK-001, a proprietary antisense oligonucleotide (ASO) that has the potential to be the first disease-modifying therapy to address the genetic cause of Dravet syndrome, a severe and progressive genetic epilepsy. Stoke is headquartered in Bedford, Massachusetts with offices in Cambridge, Massachusetts. For more information, visit https://www.stoketherapeutics.com/ or follow the company on Twitter at @StokeTx.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to: our expectations about Companys proprietary approach to precisely upregulate protein expression using TANGO ASOs and the potential benefits thereof. These forward-looking statements may be accompanied by such words as aim, anticipate, believe, could, estimate, expect, forecast, goal, intend, may, might, plan, potential, possible, will, would, and other words and terms of similar meaning. These forward-looking statements involve risks and uncertainties, as well as assumptions, which, if they do not fully materialize or prove incorrect, could cause our results to differ materially from those expressed or implied by such forward-looking statements. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements, including: risks related to the direct and indirect impact of COVID-19; our ability to develop, obtain regulatory approval for and commercialize current and future product candidates; the timing and results of preclinical studies and clinical trials; the risk that positive results in a clinical trial may not be replicated in subsequent trials or success in early stage clinical trials may not be predictive of results in later stage clinical trials; risks associated with clinical trials, including our ability to adequately manage clinical activities, unexpected concerns that may arise from additional data or analysis obtained during clinical trials; the risk that regulatory authorities may require additional information or further studies, or may fail to approve or may delay approval of our drug candidates; risks related to the occurrence of adverse safety events; risks related to failure to protect and enforce our intellectual property, and other proprietary rights; risks related to failure to successfully execute or realize the anticipated benefits of our strategic and growth initiatives; risks relating to technology failures or breaches; our dependence on collaborators and other third parties for the development, regulatory approval, and commercialization of products and other aspects of our business, which are outside of our full control; risks associated with current and potential delays, work stoppages, or supply chain disruptions caused by the coronavirus pandemic; risks associated with current and potential future healthcare reforms; risks relating to attracting and retaining key personnel; failure to comply with legal and regulatory requirements; risks relating to access to capital and credit markets; environmental risks; risks relating to the use of social media for our business; and the other risks and uncertainties that are described in the Risk Factors section of our most recent annual or quarterly report and in other reports we have filed with the U.S. Securities and Exchange Commission. These statements are based on our current beliefs and expectations and speak only as of the date of this press release. We do not undertake any obligation to publicly update any forward-looking statements.

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Trending: CRISPR And CRISPR-Associated Genes Market Research Key Players, Industry Overview and forecasts to | Thermo Fisher Scientific, Editas…

Posted on July 10, 2020 by Danzig

LOS ANGELES, United States: QY Research has recently published a report, titled Global CRISPR And CRISPR-Associated Genes Market Size, Status and Forecast 2020-2026. The research report gives the potential headway openings that prevails in the global market. The report is amalgamated depending on research procured from primary and secondary information. The global CRISPR And CRISPR-Associated Genes market is relied upon to develop generously and succeed in volume and value during the predicted time period. Moreover, the report gives nitty gritty data on different manufacturers, region, and products which are important to totally understanding the market.

Key Companies/Manufacturers operating in the global CRISPR And CRISPR-Associated Genes market include: Thermo Fisher Scientific, Editas Medicine, Caribou Biosciences, CRISPR therapeutics, Intellia therapeutics, Inc., Cellectis, Horizon Discovery Plc, Sigma Aldrich, Precision Biosciences, Genscript, Sangamo Biosciences Inc., Lonza Group Limited, Integrated DNA Technologies, New England Biolabs, Origene Technologies CRISPR And CRISPR-Associated Genes

Get PDF Sample Copy of the Report to understand the structure of the complete report: (Including Full TOC, List of Tables & Figures, Chart) :

https://www.qyresearch.com/sample-form/form/1941094/global-crispr-and-crispr-associated-genes-market

Segmental Analysis

Both developed and emerging regions are deeply studied by the authors of the report. The regional analysis section of the report offers a comprehensive analysis of the global CRISPR And CRISPR-Associated Genes market on the basis of region. Each region is exhaustively researched about so that players can use the analysis to tap into unexplored markets and plan powerful strategies to gain a foothold in lucrative markets.

Global CRISPR And CRISPR-Associated Genes Market Segment By Type:

CRISPR is a type of gene-editing technology that lets scientists more rapidly and accurately cut and paste genes into DNA. Market Analysis and Insights: Global CRISPR And CRISPR-Associated Genes Market The global CRISPR And CRISPR-Associated Genes market size is projected to reach US$ XX million by 2026, from US$ XX million in 2020, at a CAGR of XX%% during 2021-2026. Global CRISPR And CRISPR-Associated Genes Scope and Market Size CRISPR And CRISPR-Associated Genes market is segmented 7, and 4. Players, stakeholders, and other participants in the global CRISPR And CRISPR-Associated Genes market will be able to gain the upper hand as they use the report as a powerful resource. The segmental analysis focuses on revenue and forecast 7 and 4 in terms of revenue and forecast for the period 2015-2026. The following players are covered in this report:Thermo Fisher ScientificEditas MedicineCaribou BiosciencesCRISPR therapeuticsIntellia therapeutics, Inc.CellectisHorizon Discovery PlcSigma AldrichPrecision BiosciencesGenscriptSangamo Biosciences Inc.Lonza Group LimitedIntegrated DNA TechnologiesNew England BiolabsOrigene Technologies CRISPR And CRISPR-Associated Genes

Global CRISPR And CRISPR-Associated Genes Market Segment By Application:

Biotechnology CompaniesPharmaceutical CompaniesAcademic InstitutesResearch and Development Institutes

Competitive Landscape

Competitor analysis is one of the best sections of the report that compares the progress of leading players based on crucial parameters, including market share, new developments, global reach, local competition, price, and production. From the nature of competition to future changes in the vendor landscape, the report provides in-depth analysis of the competition in the global CRISPR And CRISPR-Associated Genes market.

Key companies operating in the global CRISPR And CRISPR-Associated Genes market include Thermo Fisher Scientific, Editas Medicine, Caribou Biosciences, CRISPR therapeutics, Intellia therapeutics, Inc., Cellectis, Horizon Discovery Plc, Sigma Aldrich, Precision Biosciences, Genscript, Sangamo Biosciences Inc., Lonza Group Limited, Integrated DNA Technologies, New England Biolabs, Origene Technologies CRISPR And CRISPR-Associated Genes

Key questions answered in the report:

For Discount, Customization in the Report: https://www.qyresearch.com/customize-request/form/1941094/global-crispr-and-crispr-associated-genes-market

TOC

1 Report Overview1.1 Study Scope1.2 Key Market Segments1.3 Players Covered: Ranking by CRISPR And CRISPR-Associated Genes Revenue1.4 Market 71.4.1 Global CRISPR And CRISPR-Associated Genes Market Size Growth Rate 7: 2020 VS 20261.4.2 Genome Editing1.4.3 Genetic Engineering1.4.4 GRNA Database/Gene Librar1.4.5 CRISPR Plasmid1.4.6 Human Stem Cells1.4.7 Genetically Modified Organisms/Crops1.4.8 Cell Line Engineering1.5 Market by Application1.5.1 Global CRISPR And CRISPR-Associated Genes Market Share 4: 2020 VS 20261.5.2 Biotechnology Companies1.5.3 Pharmaceutical Companies1.5.4 Academic Institutes1.5.5 Research and Development Institutes1.6 Study Objectives1.7 Years Considered 2 Global Growth Trends2.1 Global CRISPR And CRISPR-Associated Genes Market Perspective (2015-2026)2.2 Global CRISPR And CRISPR-Associated Genes Growth Trends by Regions2.2.1 CRISPR And CRISPR-Associated Genes Market Size by Regions: 2015 VS 2020 VS 20262.2.2 CRISPR And CRISPR-Associated Genes Historic Market Share by Regions (2015-2020)2.2.3 CRISPR And CRISPR-Associated Genes Forecasted Market Size by Regions (2021-2026)2.3 Industry Trends and Growth Strategy2.3.1 Market Top Trends2.3.2 Market Drivers2.3.3 Market Challenges2.3.4 Porters Five Forces Analysis2.3.5 CRISPR And CRISPR-Associated Genes Market Growth Strategy2.3.6 Primary Interviews with Key CRISPR And CRISPR-Associated Genes Players (Opinion Leaders) 3 Competition Landscape by Key Players3.1 Global Top CRISPR And CRISPR-Associated Genes Players by Market Size3.1.1 Global Top CRISPR And CRISPR-Associated Genes Players by Revenue (2015-2020)3.1.2 Global CRISPR And CRISPR-Associated Genes Revenue Market Share by Players (2015-2020)3.1.3 Global CRISPR And CRISPR-Associated Genes Market Share by Company Type (Tier 1, Tier 2 and Tier 3)3.2 Global CRISPR And CRISPR-Associated Genes Market Concentration Ratio3.2.1 Global CRISPR And CRISPR-Associated Genes Market Concentration Ratio (CR5 and HHI)3.2.2 Global Top 10 and Top 5 Companies by CRISPR And CRISPR-Associated Genes Revenue in 20193.3 CRISPR And CRISPR-Associated Genes Key Players Head office and Area Served3.4 Key Players CRISPR And CRISPR-Associated Genes Product Solution and Service3.5 Date of Enter into CRISPR And CRISPR-Associated Genes Market3.6 Mergers & Acquisitions, Expansion Plans 4 Market Size 7 (2015-2026)4.1 Global CRISPR And CRISPR-Associated Genes Historic Market Size 7 (2015-2020)4.2 Global CRISPR And CRISPR-Associated Genes Forecasted Market Size 7 (2021-2026) 5 Market Size 4 (2015-2026)5.1 Global CRISPR And CRISPR-Associated Genes Market Size 4 (2015-2020)5.2 Global CRISPR And CRISPR-Associated Genes Forecasted Market Size 4 (2021-2026) 6 North America6.1 North America CRISPR And CRISPR-Associated Genes Market Size (2015-2020)6.2 CRISPR And CRISPR-Associated Genes Key Players in North America (2019-2020)6.3 North America CRISPR And CRISPR-Associated Genes Market Size 7 (2015-2020)6.4 North America CRISPR And CRISPR-Associated Genes Market Size 4 (2015-2020) 7 Europe7.1 Europe CRISPR And CRISPR-Associated Genes Market Size (2015-2020)7.2 CRISPR And CRISPR-Associated Genes Key Players in Europe (2019-2020)7.3 Europe CRISPR And CRISPR-Associated Genes Market Size 7 (2015-2020)7.4 Europe CRISPR And CRISPR-Associated Genes Market Size 4 (2015-2020) 8 China8.1 China CRISPR And CRISPR-Associated Genes Market Size (2015-2020)8.2 CRISPR And CRISPR-Associated Genes Key Players in China (2019-2020)8.3 China CRISPR And CRISPR-Associated Genes Market Size 7 (2015-2020)8.4 China CRISPR And CRISPR-Associated Genes Market Size 4 (2015-2020) 9 Japan9.1 Japan CRISPR And CRISPR-Associated Genes Market Size (2015-2020)9.2 CRISPR And CRISPR-Associated Genes Key Players in Japan (2019-2020)9.3 Japan CRISPR And CRISPR-Associated Genes Market Size 7 (2015-2020)9.4 Japan CRISPR And CRISPR-Associated Genes Market Size 4 (2015-2020) 10 Southeast Asia10.1 Southeast Asia CRISPR And CRISPR-Associated Genes Market Size (2015-2020)10.2 CRISPR And CRISPR-Associated Genes Key Players in Southeast Asia (2019-2020)10.3 Southeast Asia CRISPR And CRISPR-Associated Genes Market Size by Type (2015-2020)10.4 Southeast Asia CRISPR And CRISPR-Associated Genes Market Size by Application (2015-2020) 11 India11.1 India CRISPR And CRISPR-Associated Genes Market Size (2015-2020)11.2 CRISPR And CRISPR-Associated Genes Key Players in India (2019-2020)11.3 India CRISPR And CRISPR-Associated Genes Market Size by Type (2015-2020)11.4 India CRISPR And CRISPR-Associated Genes Market Size by Application (2015-2020) 12 Central & South America12.1 Central & South America CRISPR And CRISPR-Associated Genes Market Size (2015-2020)12.2 CRISPR And CRISPR-Associated Genes Key Players in Central & South America (2019-2020)12.3 Central & South America CRISPR And CRISPR-Associated Genes Market Size by Type (2015-2020)12.4 Central & South America CRISPR And CRISPR-Associated Genes Market Size by Application (2015-2020) 13 Key Players Profiles13.1 Thermo Fisher Scientific13.1.1 Thermo Fisher Scientific Company Details13.1.2 Thermo Fisher Scientific Business Overview13.1.3 Thermo Fisher Scientific CRISPR And CRISPR-Associated Genes Introduction13.1.4 Thermo Fisher Scientific Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020))13.1.5 Thermo Fisher Scientific Recent Development13.2 Editas Medicine13.2.1 Editas Medicine Company Details13.2.2 Editas Medicine Business Overview13.2.3 Editas Medicine CRISPR And CRISPR-Associated Genes Introduction13.2.4 Editas Medicine Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020)13.2.5 Editas Medicine Recent Development13.3 Caribou Biosciences13.3.1 Caribou Biosciences Company Details13.3.2 Caribou Biosciences Business Overview13.3.3 Caribou Biosciences CRISPR And CRISPR-Associated Genes Introduction13.3.4 Caribou Biosciences Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020)13.3.5 Caribou Biosciences Recent Development13.4 CRISPR therapeutics13.4.1 CRISPR therapeutics Company Details13.4.2 CRISPR therapeutics Business Overview13.4.3 CRISPR therapeutics CRISPR And CRISPR-Associated Genes Introduction13.4.4 CRISPR therapeutics Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020)13.4.5 CRISPR therapeutics Recent Development13.5 Intellia therapeutics, Inc.13.5.1 Intellia therapeutics, Inc. Company Details13.5.2 Intellia therapeutics, Inc. Business Overview13.5.3 Intellia therapeutics, Inc. CRISPR And CRISPR-Associated Genes Introduction13.5.4 Intellia therapeutics, Inc. Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020)13.5.5 Intellia therapeutics, Inc. Recent Development13.6 Cellectis13.6.1 Cellectis Company Details13.6.2 Cellectis Business Overview13.6.3 Cellectis CRISPR And CRISPR-Associated Genes Introduction13.6.4 Cellectis Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020)13.6.5 Cellectis Recent Development13.7 Horizon Discovery Plc13.7.1 Horizon Discovery Plc Company Details13.7.2 Horizon Discovery Plc Business Overview13.7.3 Horizon Discovery Plc CRISPR And CRISPR-Associated Genes Introduction13.7.4 Horizon Discovery Plc Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020)13.7.5 Horizon Discovery Plc Recent Development13.8 Sigma Aldrich13.8.1 Sigma Aldrich Company Details13.8.2 Sigma Aldrich Business Overview13.8.3 Sigma Aldrich CRISPR And CRISPR-Associated Genes Introduction13.8.4 Sigma Aldrich Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020)13.8.5 Sigma Aldrich Recent Development13.9 Precision Biosciences13.9.1 Precision Biosciences Company Details13.9.2 Precision Biosciences Business Overview13.9.3 Precision Biosciences CRISPR And CRISPR-Associated Genes Introduction13.9.4 Precision Biosciences Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020)13.9.5 Precision Biosciences Recent Development13.10 Genscript13.10.1 Genscript Company Details13.10.2 Genscript Business Overview13.10.3 Genscript CRISPR And CRISPR-Associated Genes Introduction13.10.4 Genscript Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020)13.10.5 Genscript Recent Development13.11 Sangamo Biosciences Inc.10.11.1 Sangamo Biosciences Inc. Company Details10.11.2 Sangamo Biosciences Inc. Business Overview10.11.3 Sangamo Biosciences Inc. CRISPR And CRISPR-Associated Genes Introduction10.11.4 Sangamo Biosciences Inc. Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020)10.11.5 Sangamo Biosciences Inc. Recent Development13.12 Lonza Group Limited10.12.1 Lonza Group Limited Company Details10.12.2 Lonza Group Limited Business Overview10.12.3 Lonza Group Limited CRISPR And CRISPR-Associated Genes Introduction10.12.4 Lonza Group Limited Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020)10.12.5 Lonza Group Limited Recent Development13.13 Integrated DNA Technologies10.13.1 Integrated DNA Technologies Company Details10.13.2 Integrated DNA Technologies Business Overview10.13.3 Integrated DNA Technologies CRISPR And CRISPR-Associated Genes Introduction10.13.4 Integrated DNA Technologies Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020)10.13.5 Integrated DNA Technologies Recent Development13.14 New England Biolabs10.14.1 New England Biolabs Company Details10.14.2 New England Biolabs Business Overview10.14.3 New England Biolabs CRISPR And CRISPR-Associated Genes Introduction10.14.4 New England Biolabs Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020)10.14.5 New England Biolabs Recent Development13.15 Origene Technologies10.15.1 Origene Technologies Company Details10.15.2 Origene Technologies Business Overview10.15.3 Origene Technologies CRISPR And CRISPR-Associated Genes Introduction10.15.4 Origene Technologies Revenue in CRISPR And CRISPR-Associated Genes Business (2015-2020)10.15.5 Origene Technologies Recent Development 14 Analysts Viewpoints/Conclusions 15 Appendix15.1 Research Methodology15.1.1 Methodology/Research Approach15.1.2 Data Source15.2 Disclaimer15.3 Author Details

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Europe Genetic Testing Services Market is expected to reach US$ 5840.9 Million by 2027 with CAGR of 11.4%. – Owned

Posted on July 10, 2020 by Danzig

Genetic tests, also called DNA tests, are used to identify changes in DNA sequences or chromosomal structures. Genetic testing also includes measuring the consequences of genetic alterations, such as RNA analysis as an output of gene expression, and biochemical analysis to measure specific protein outputs.

The Europe Genetic testing services market is expected to reach US$ 5,840.9 Mn in 2027 from US$ 2,521.6 Mn in 2019. The market is estimated to grow with a CAGR of 11.4% from 2020-2027.

Genetic testing is a type of medical test that identifies changes in chromosomes, genes, or proteins. The results of genetic tests can help identify or rule out suspicious genetic conditions or determine the likelihood of someone developing or inheriting a genetic disorder.

A medical device is any device intended to be used for medical purposes. Medical devices benefit patients by helping health care providers diagnose and treat patients and helping patients overcome sickness or disease, improving their quality of life.

The healthcare industryis undergoing rapid transformations since a few years now. Various technological improvementshave been witnessedin the segments including diagnosis and treatment options for chronic diseases. The increase in incidences of chronic illnesses and the increasing ageing population are the primary factors fuelling the growth of healthcare segment.

The Europe Genetic Testing Servicesmarketis growing along with the healthcare industry, but the market is likely to slow down its growth due to the shortage of skilled professionals, suggests the Business Market Insights report.

The Business Market Insights subscription helps clients understand theongoingmarket trends,identifyopportunities, and make informed decisions through the reports in the Subscription Platform. The Industry reports available in the subscriptionprovidean in-depth analysis on various market topics and enable clients to line up remunerative opportunities. The reportsprovidethe market size & forecast, drivers, challenges, trends, and more.

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France has well-developed policies and strategies in place for improving the prevention of hereditary cancers. Also, France is planning to develop a national plan for personalized medicine. Genomic Medicine France 2025, which was published in 2016, which appeals for healthcare and manufacturing firms to pilot genomic sequencing platforms. By 2020 the aim is to establish a network of centers able to process around 235,000 samples for whole genome sequencing.

These factorsare expectedto offer broad growth opportunities in the healthcare industry and this is expected to cause the demand forimmunochemistryassays in the market.

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Business Market Insights reports are usefulnot only forcorporate and academic professionalsbut also forconsulting, research firms,PEVCfirms, and professional services firms.

EUROPE GENETIC TESTING SERVICES MARKET SEGMENTATION

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By Disease

By Service Provider

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Europe Genetic Testing Services Market is expected to reach US$ 5840.9 Million by 2027 with CAGR of 11.4%. - Owned

Photos: Why The Gypsum Hills Are The ‘Best Kept Secret’ In Kansas – KMUW

Posted on July 10, 2020 by Danzig

Driving west from Sedgwick County on state Highway 160, the scenery is what youd probably expect on a Kansas road trip: farmland, a few rolling hills and the horizon stretching out in all directions.

Listen to this segment of Hidden Kansas, part of KMUW's weekly program The Range.

But just southwest of Medicine Lodge, theres a dramatic change. Ken Brunson, the Red Hills project coordinator for the Kansas Nature Conservancy, calls it the best-kept secret in the state.

"It's a beautiful, iconic country of buttes and mesas and grasslands and the red dirt and the gypsum outcrops," Brunson said. "Its the only place in Kansas where youll find that combination."

Brunson has worked in the Gypsum Hills or Gyp Hills for nine years.

The Nature Conservancys goals are to protect the land and streams, the wildlife, and the gypsum formations that give the area its unusual topography. This is ranch country, wild and windy and mostly too rough to farm.

There are dozens of ranches, ranging from a few thousand acres to Ted Turners massive Z-Bar Ranch, which covers nearly 43,000 acres sprawling west into Comanche County.

"They have ranches that have been passed down for generations," Brunson said. "They take great pride in the land and being able to make a living off the cattle industry here."

Most of this area is private land, but you can drive through it. Highway 160 west of Medicine Lodge is a designated scenic byway.

Another scenic drive heads south from 160; there are small back county roads barely wide enough for one car.

The smaller roads can be a bit rough in spots and definitely not meant for cars that are low to the ground. But its worth it. The craggy hills and canyons mingle with surprising bursts of color; green grasslands, red earth and carpets of wildflowers. (Purple poppy mallow)

In places, yellow sweet clover lines the roads, providing an irresistible photo op.

The Gyp Hills and the Red Hills just to the west contain the second largest intact grassland in the state, where cattle, bison and other wildlife come to graze.

Brunson will be retiring at the end of this year, and says he has mixed feelings at the thought of leaving it all.

"I love this beautiful land. Ill miss it and the wonderful people who live here and work it."

"I do refer to this country as 'the Enchanted Land,' stealing it from New Mexico," he said. "But there are some similarities [to New Mexico] with all the outcrops and hills and canyons. Its a different view from what a lot of people think of as Kansas."

As summer stretches on and the coronavirus shows no sign of letting up, people are being urged to use caution when traveling. That trip to the beach or mountains may be out this year. But the Gyp Hills have a rugged beauty that's different than what you usually see in south-central Kansas.

Its an easy day trip from Wichita but make sure you gas up before leaving Medicine Lodge. And you definitely want to bring a map.

Hidden Kansas explores intriguing spots across our state. Listen for a new segment each month on KMUW's The Range.

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Photos: Why The Gypsum Hills Are The 'Best Kept Secret' In Kansas - KMUW

Armed Man Who Allegedly Stormed Trudeau’s Residence Appears to Have Posted QAnon Content – VICE

Posted on July 10, 2020 by Danzig

Photos via Grindhouse Fine Foods Instagram and THE CANADIAN PRESS/ADRIAN WYLD

Update: This post has been updated to include the charges against Corey Hurren and comment from Marc-Andr Argentino.

Less than an hour before Corey Hurren allegedly drove his pickup truck through the gates of Rideau Hall, where Prime Minister Justin Trudeau lives, a social media account for his business posted a meme that blames the global elite for COVID-19.

At 6:05 AM, the Instagram account for Grindhouse Fine Foods, the company Hurren operates, posted a meme relating to Event 201a pandemic training event put on in part by the Bill Gates Foundation. At 6:40 AM, RCMP said Hurren rammed his truck, which contained multiple firearms, through the gates hard enough to set his airbags off. He left the truck on foot with a rifle in his hand and was intercepted by RCMP officers who, after hours of negotiation, were able to take him into custody without incident just before 8:30 A.M.

On Friday afternoon, RCMP announced a slew of firearms charges against Hurren, a member of the Canadian Armed Forces Reserve. They include: four counts of careless use of a firearm, four counts of illegally transporting of a firearm, four counts of possession of a weapon for a dangerous reason, one count of possession of of a prohibited devices, four counts of possession of a restricted firearm with ammunition, and one count of uttering threats. Hurren attended a bail hearing Friday afternoon but it was pushed back until July 17. He will remain in police custody till then.

RCMP Deputy Commissioner Mike Duheme said there was never any danger to Trudeau or Governor General Julie Payette as they werent at their homes at the time of the incident. While the RCMP says the man had several weapons on him they did not elaborate about the specifics of the weapons.

Citing anonymous sources, several media outlets have reported that Hurren was armed with several rifles and a shotgun, at least one of which was on him at the time of his arrest. Hurren also allegedly had a note on him that he wished to deliver to Trudeau.

According to LinkedIn, Hurren has operated Grindhouse Fine Foods, a meat company, since 2014. The companys Instagram account features posts that are related to the business, such as images of sausages, and others that are personal in nature, such as photos of Hurren.

Hurren in a Instagram post from Decemeber 2019. Photo via Grindhouse Fine Foods Instagram.

On March 27, Grindhouse Fine Foods posted a QAnon meme. It features a white rabbit (the mascot for the conspiracy) at the wheel of a car. The Instagram caption says: Has anyone else been following 'Q' and the 'White Rabbit' down the rabbit hole and how this all relates to the coronavirus/COVID-19 situation? Lots of coincidences in all these 'Q' posts if this turns out to be a 'Nothingburger'." He then lists a plethora of conspiracies in the hashtags which include the killing of Seth Rich, adrenochrome, pizzagate, pedogate, and several related to sex offender Jeffery Epstein. The account also posted several hashtags linked to QAnon like WWG1WGA, a storm is coming, and the deep state.

QAnon is a wide-ranging conspiracy in the United States that focuses on Donald Trumps battles with deep state enemies.

Marc-Andr Argentino, a PhD candidate at Concordia University who studies QAnon and similar movements, flagged Hurren's post to VICE. Argentino said Hurren's posts indicate that he's not a die-hard QAnon adherent, but may have gotten into the movement during the pandemic because of economic and political stress. However, Argentino stressed that we still dont have the full picture of what Hurren believes at the moment.

He's consumed enough of the content to know the very specific hashtags to use, said Argentino.

The meme Grindhouse posted shortly before Hurren allegedly rammed the gates at Rideau Hall was also posted to the account in May. It refers to Event 201, an international training exercise put on by Johns Hopkins Center for Health Security, the Bill and Melinda Gates Foundation, and the World Economic Forum in October 2019. The exercise was to test the readiness of the world in the event of a global pandemic. Many conspiracy theorists believe it indicates that Bill Gates, alongside other elites, orchestrated the pandemic. The Event 201 post was first reported on by the Toronto Star.

Hurren is from Bowsman, Manitoba, one of the northernmost farming communities in the province. In Grindhouses social media posts, Hurren frequently refers to the fact hes a veteran who recently rejoined the military as a Canadian Rangers member. The Rangers are a part of the national reserve that serve in remote regions.

A robot with the bomb squad recovered a collection of military rations in Hurren's vehicle following the arrest.

The instagram post referring to QAnon. Photo via Grindhouse Fine Foods Instagram.

In one of Grindhouses Instagram posts, Hurren said he had to temporarily shut down his business because of COVID-19.

"As some of you may already know, things have been on hold with my GrindHouse meat products due to the logistics of the COVID-19 situation," he wrote. "I am not sure what will be left of our economy, industries, and businesses when this all ends."

For most of the year, the posts focused on his company (his Ring of Fire sausage, in particular,) his time with the Rangers, and survivalism. That changed in March when COVID-19 hit, and the posts became far more focused on the pandemic and began to reference conspiracies.

The day before Hurren allegedly rammed the gates, an anti-Trudeau rally took place in Ottawa. While the rally was about a variety of subjects, including pushing back on COVID-19 safety measures, many of the attendees were adherents of the conspiracy. Footage of the gathering, which drew hundreds of people, was amplified by Q, the central figure of the QAnon conspiracy. Photos of the event show many attendees holding signs relating to Q. The group chanted where we go one we go all, the main slogan of the conspiracy.

There is no evidence directly linking Hurren to the rally. Duchene said at the press conference that as far as he knew, the suspect was not in Ottawa for another reason but declined to go into any details relating to his travel or activities in Ottawa prior to breaking through the gates of Rideau Hall armed.

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Armed Man Who Allegedly Stormed Trudeau's Residence Appears to Have Posted QAnon Content - VICE

ISC Result 2020 Released at cisce.org and results.cisce.org: How to Check CISCE Results Online, via SMS – News18

Posted on July 10, 2020 by Danzig

ISC Result 2020 Announced | As the Central Board of Secondary Education (CBSE) is yet to announce the results for Class 10 and 12 Board Results 2020, the Council for the Indian School Certificate Examinations has taken a step ahead. The CISCE has released the board results for Indian Certificate of Secondary Education and Indian School Certificate on Friday, July 11.

The ISC Class 12 Board Result 2020 is declared on the official website at cisce.org and results.cisce.org. The CISCE scheduled the ISC Exams in the month of February and March this year, however the board has to postpone the examination of a few subjects due to the Covid-19 outbreak in the country.

Earlier, the pending examinations for CISCE Class 12 2020 were scheduled to be conducted in July. However, keeping the Covid-19 situation in the country in the mind, the board decided to cancel all the examinations for the academic year.

CISCE ISC Assessment Process

CISCE has to cancel the pending examination for both ICSE and ISC students. For the subjects whose pending exams were cancelled, the board will assess students on the basis of internal exams. If a student fails to obtain the minimum marks to pass the subject, he/she will be getting the option to re-appear for the exams on a later date.

CISCE ISC Marksheet and Passing Certificate

The CISCE Board will upload the marksheet and the passing certificate for ISC Class 12 Results 48 hours after the declaration of the result. If a student is not satisfied with his or her marks, they are free to apply for the rechecking or revaluation process. A fee of Rs 1,000 will be charged per subject per student. The re-evaluation window is open from July 10 to 16.

CISCE ISC Exam Results

The students can check CISCE ISC Results online through the official website using their registration number. To check the ISC result 2020 through SMS, students need to type ISC roll number and send their test to 09248082883.

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ISC Result 2020 Released at cisce.org and results.cisce.org: How to Check CISCE Results Online, via SMS - News18

Adapting Sword Art Onlines massive world into a JRPG – PlayStation.Blog

Posted on July 10, 2020 by Danzig

Since its introduction in 2013, the Sword Art Online anime has garnered a huge number of fans worldwide. Its easy to see why, with its colorful cast of characters and exploration of the psychological effects of virtual reality. Sword Art Online Alicization Lycoris, out tomorrow, allows players to experience the animes latest arc in JRPG form. We spoke with Lead Producer, Yousuke Futami, to get the inside scoop on the latest addition to the Sword Art Online game series.

Q: This game follows the Alicization arc of the anime. What made you decide to follow the canon anime storyline instead of creating a game-specific storyline?

When describing the Alicization Arc, in order to express the vast world of the original work and the anime, we came to the conclusion that the opening part should be the same between the anime and the game. We wanted to explore themes of the original work such as Kirito and Eugios friendship, Artificial Intelligence, the differences among humans, what defines a spirit and so on. It is straightforward even for those who watch the anime or read the original work but havent played the previous games, so I think it is easier to jump in.

Q: Were there any challenges in adapting the anime storyline into a video game?

As you know, the volume of the first half of the Alicization anime is colossal. I assumed we could actually make a game out of the first 24 episodes. With that massive volume in mind, it was challenging to adapt the story in a way that it could coexist with the gameplay. We made sure players can play the anime story in the game without feeling stressed.

Q: Medina Orthinanos is a new game-original character. Can you take us through the process of creating a new character for a story that is already established?

We made her appear in the game sooner than many of the fans would probably expect. Kirito and Eugeo meet her just when they leave Rulid Village, but she goes to the Academy like Eugeo and the important point is that this spins into the later part of the story. Medina is a very strong and honest character. As AI lives are almost like the humans in the Under World, we set her character as someone who would explode their feelings.

In the anime and the original work, Alices struggle is shown, and in the game, there are friends like Kirito and Eugeo to share with. Media is a contrast; she is looked down on by different people. She was created to express the feelings, essential as an AI in this world. Medina has a very important role in the game version of the Alicization arc. Without her, the games theme cant be told. I really hope you can experience the games message throughout the journey with Medina.

Q: Did you have any reservations about adding an original character into the story?

As a daughter of a noble family, Medina is burdened with the dark side of the aristocracy and the humans. This part follows the original work or the anime settings, so we did not have reservations with adding her into the game.

Q: Should fans expect more Sword Art Online games that will follow the anime storyline?

Of course! I hope that young talents yet to come will create new SAO games for the next generation.

Q: What do you think sets Sword Art Online Alicization Lycoris apart from previous SAO games?

The battles feature the AI quite a lot. Your partner character will memorize their move sets as they fight more and more enemies. You can set and customize your partners memorized moves on your own, upload it, download from other online players partner AI, and so on.

Since it grows quickly as you fight, you can feel the members becoming stronger. Compared to past SAO games, this title has evolved for you to experience more SAO-like battles. I hope you enjoy playing the game with many of the partner characters you can choose from.

Q: What are you most excited about for fans to experience in this game?

I hope that fans will enjoy the world of SAO Alicization, experience the SAO story only told in this game with their favorite characters, and also have fun exploring the world of Underworld in general. I hope they can sense the meaning of the games catchphrase: The world will never forget you through their gameplay experience.

Sword Art Online Alicization Lycoris comes out tomorrow, July 10. Pick up a digital copy of the game for PS4 before August 13, 2020 to receive four bonus costumes.

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Adapting Sword Art Onlines massive world into a JRPG - PlayStation.Blog

Gautam Buddha gave his first sermon on Guru Purnima: A look at some of his teachings and quotes – Times Now

Posted on July 10, 2020 by Danzig

Gautam Buddha gave his first sermon on Guru Purnima: A look at some of his teachings and quotes

Guru Purnima, a day meant for paying an ode to teachers and mentors in India, is observed on the Purnima Tithi (full Moon night) in the month of Ashadha as per the Purnimant calendar. This year, Guru Purnima, which also marks the birth anniversary of sage Veda Vyasa, will be celebrated on July 5. Interestingly, Guru Purnima is also a significant day for followers of Buddhism. Read on to know why the festival is of great relevance to the Buddhists.

Gautama Buddha is believed to have given his first sermon at Sarnath after attaining enlightenment in Bodh Gaya. It is said that Lord Buddha travelled from Bodh Gaya to Sarnath five weeks after getting enlightened.

Buddha's five ascetic disciples, known asPanchavargika, had moved to ipatana (Rishipatana) in Sarnath even when Gautama Buddha was in Uruvilva (Bodh Gaya). After attaining enlightenment, Buddha marched towards Sarnath to give his first sermon to thePanchavargika. And since he delivered his first sermon,Dharmachakrapravartana Sutta, on the day of Ashadha Purnima, it is significant for the Buddhists.

Dharmachakrapravartana Suttaalso referred to as the wheel ofDharmaconsists of the following:

Four Noble truths- Dukkha (sufferings), Tanha (desire), Nirodha (renouncement) and Magga (the path to enlightenment)

Ariya Ahagika Magga- right view, right resolve, right speech, right action, right livelihood, right effort, right mindfulness and right samadhi.

On Guru Purnima day, Buddhists perform the Uposatha, a spiritual ritual that results in the cleansing of the impure mind. They also pay ode to their Gurus on this auspicious day.

Lord Buddha, the founder of the Buddhist religion, was formerly known as Siddhartha Gautama. He was born to King Suddhodana of the aristocratic Shakya clan and his Queen Mayadevi in Lumbini on the Purnima Tithi (full Moon night) in the month of Vaishakh. Incidentally, it is also on the same day, many years later, that Siddhartha attained enlightenment while meditating under a Peepal (Banyan) tree to become Buddha.

Interestingly, despite being born into a royal family with all the comforts and luxuries, Siddhartha chose to abandon mundane life. He stepped out of his palace in search of truth, and after performing penance for years, he attained knowledge that transcended the material world.

Here's wishing one and all a very happy Guru Purnima.

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Gautam Buddha gave his first sermon on Guru Purnima: A look at some of his teachings and quotes - Times Now

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