Pirates of the Caribbean: How Johnny Depp OVERCAME Disney’s nervous low expectations – Express

Back in 2003, Pirates of the Caribbean: The Curse of the Black Pearl hit cinemas, making over $650 million worldwide and bagging a Best Actor Oscar nomination for Johnny Depps Captain Jack Sparrow. Almost 20 years later and the gamble of a film based on a Disneyland Ride has massively paid off, spawning four sequels to date, with a sixth film in the works, and billions made at the box office. But now Greg Ellis, who played Lieutenant Commander Theodore Groves in three of the five Pirates movies has revealed how there was a feeling of nervousness and low expectations at the first films cast reading.

Speaking exclusively with Express.co.uk, the 52-year-old who was promoting his video podcast series The Respondent said: I remember the first cast read-through we had at The Viper Room on Sunset, the famous club.

Depp owned the venue at the time, which is presumably why the script reading took place there.

Painting a picture of the scene, Ellis continued: It was this strange mixture of LA-based actors, superstars, celebrities.

There were about eight or nine actors who had flown in from England; literally jet-lagged, pasty faced.

READ MORE:Pirates of the Caribbean star reveals Johnny Depps acting process

The Lieutenant Groves actorspoke of how representatives from Disney and producer Jerry Bruckheimer were all sitting around the outside of a big long table with Depp, Barbossa star Geoffrey Rush and others.

Apparently many of the actors were smoking and you could hear the coughs from the executives.

Ellis said: I remember that day I read quite a few characters because only about 15 of the core cast were there.

There was nervousness and low expectation.

It had been almost a decade since the last Hollywood movie about pirates (other than Muppet Treasure Island) hit cinemas.

Cutthroat Island, starring Geena Davis and Matthew Modine, was a total bomb and led to the closure of Carolco Pictures as a result.

With this in mind, Ellis said of the first Pirates of the Caribbean movie: Nobody expected it to do as well as it did.

And Disney were particularly concerned with Depps Jack Sparrow character, who would go on to be one of the most iconic blockbuster leads of the 21st century so far.

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Ellis said: Johnnys career up until that point, he was a superstar who did seemingly independent movies.

For him to combine with the huge corporate world of Disney and play a doddering, slightly drunken, effeminate, overly-dressed pirateI think there was a lot of nerves on the studios part of how audiences would receive it.

The Pirates actor even pointed out how Depp overdressed himself by a third for a Jack Sparrow costume fitting as he knew the studio would want to tone down his look.

Even Depp himself has previously claimed, in an interview with GQ, how Disney hated his vision for the pirate and were thinking of every way they could to get rid of me, to fire me.

Ellis new video podcast series The Respondent explores a whole host of topics includingpositive masculinity, family law, parenting, sexuality, men's rights, comedy and greek gods.

The actor also explores how families communicate, how we cope with device dependency and finding the good in people.

He argued: All of that conversation seems to have been very stilted, stopped and stunted in the court of public opinion, [which is] judging everyone and cancelling so many people who are losing their livelihoods.

To watch the first episode of Greg Ellis video podcast,click here.

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Pirates of the Caribbean: How Johnny Depp OVERCAME Disney's nervous low expectations - Express

"Return to Love" – A Song of Inspiration by Bajan Singer Krisirie – Caribbean News – caribbeannationalweekly.com

When singer Krisirie first met musicians Willie Stewart and Handel Tucker at Stewarts On The Beat recording studio in South Florida three years ago, there was an instant synergy.

Call it Caribbean chemistry: Krisirie who is from Barbados and Stewart and Tucker who are Jamaicans, gelled so much that day, they co-wrote the stirring Return to Love.

That ballad was finally released in June. With Tucker on piano, Krisiries emotional plea for a peaceful world, tugs at the heart strings.

Stewart, former drummer with Grammy-nominated band Third World, and Tucker, World-Renowned Grammy Producer were blown away by the then 19-year-olds maturity and talent. From left: Tucker, Krisirie and Stewart

She has a unique sound and a sincerity in her delivery. She really has a style of her own, said Stewart. It should come as little surprise that Krisirie hit it off with her more experienced colleagues.

Born Kristen Walker, she grew up in the parish of Christ Church, Barbados listening to mainly reggae; Bob Marley, Beres Hammond and Third World are some of her biggest influences.

Because of the COVID-19, promoting Return to Love has been restricted to social media. A gripping music video has attracted a rush of longtime admirers and new fans of Krisirie who began recording three years ago.Were very happy with how things are going. The social media and public response has been great, said Stewart.

Krisirie is the latest act he and Tucker have worked with at On The Beat. Others include Krisiries compatriot, Arturo Tappin; sibling Jamaican trio, 3B4Jhoy, Josef George, a singer from the British Virgin Islands, and Norre Stephenson, brother of singer/songwriter Duane Stephenson.

Stewart, who has promoted to the successful Rhythms of Africa show in South Florida for the past 11 years, is confident Return to Love and Krisirie have the potential to go all the way. She is singing a message that the world needs to hear. Its timeless. If we dont have love, we dont have nothing, he reasoned.

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"Return to Love" - A Song of Inspiration by Bajan Singer Krisirie - Caribbean News - caribbeannationalweekly.com

Art Caribbean Fusion Cuisine brings island experience to downtown GR – WOODTV.com

GRAND RAPIDS, Mich. (WOOD) A new restaurant is bringing a taste of the islands to downtown Grand Rapids.

Art Caribbean Fusion Cuisine opened last weekend with an experience that doesnt stop at the plate. The restaurant at 55 Monroe Center NW immerses guests in Caribbean culture with original art everywhere, including traditional hand-painted metal coffee cups from the Dominican Republic, called jarros de caf.

The local artists can bring their pictures here, their art, and if customers are willing to buy it, then theyll be able to do that from here. So its a way of support also for our local artists, owner and chef Gilma DeLaCruz said.

Island music also floats through the Caribbean restaurant, which is the first of its kind downtown, according to DeLaCruz.

When you travel to the Caribbean, when you get to the airport, the first thing that they have is music, live music. So we want to be able to give you have that experience here without having to travel right now, (since) that is impossible to do, she said.

DeLaCruzs food made its mark on downtown Grand Rapids in September 2018 with the areas first Caribbean food truck, El Caribe. The pandemic forced the popular food truck to shut down for about 45 days, but it is once again feeding visitors in Rosa Parks Circle and other areas, now by pre-order.

DeLaCruz says inquiries from visitors in love with El Caribes food pushed her to expand to a place that wont have to close when winter hits.

With the food truck, we kept traveling and traveling and we had a lot of customers asking, When, where are you going to have a brick and mortar? When are we going to be able to find your food in one spot and not moving around? DeLaCruz said.

Some of the food that has made El Caribe so popular is on the menu at Art Caribbean, including the Cuban sandwich with plantain chips, steak jibarito made with plantains instead of bread, and empanadas made from scratch.

The menu also has some new options, including Caribbean nachos. Visitors can also order yuca fries and malanga fries.

Caribbean (food) is the seasoning, too. All of the flavors that we bring together in a meal when you taste it, its not just blend, but youll have different tastes, DeLaCruz said. Your taste buds will be able to have so many explosions when you try Caribbean food, from spiciness to sweet, being able to explore all of that in one dish.

Creating food is in DeLaCruzs blood. Her mother runs Rincon Criollo restaurant off Grandville Avenue near Clyde Park Avenue and her sister-in-law is the executive chef for Hard Rock Stadium in Miami.

Her relatives inspired her to pursue a career in culinary arts and helped her open Art Caribbean, from the menu planning to preparing the space.

Were a very strong family and we try to support each other, she said. So when were open, youll see my mom here running around and telling me how to do things and how to open because thats how we are. We are a family of support and we have each others back.

DeLaCruzs restaurant combines her childhood experiences of growing up in the restaurant industry and in the Dominican Republic.

I wanted to bring, share with Grand Rapids, that culture, she said.

My husband and I have always traveled to Florida (and) New York. When we go there, we love the fact that we can visit so many different restaurants and be able to have that diversity. And we wanted to have that change here in Grand Rapids. We wanted to bring that diversity and food to the downtown area, she added.

COVID-19 delayed Art Caribbeans opening by about three months. While DeLaCruz was waiting, a riot erupted downtown near her restaurant.

I did not sleep at night, she said. My husband and I were sitting on in the bed and we were like, we dont know whats going to be tomorrow morning. I mean, if they, if our business got destroyed, whats next?

Daylight brought relief in the form of a friends phone call the restaurant only needed its sign fixed and windows cleaned.

My husband was able to come here and help other businesses clean up their windows, put boards up. And it was very amazing. The night of the riots (was) a lot of sadness, (being) anxious. And the next morning was happiness, seeing how our community came together to help clean up and get all these businesses back to open, she said.

DeLaCruz says challenges created by COVID-19 are still emerging.

Probably one of my biggest right now is food supply. Prices and food have gone up. So we have had to make changes to our original menu to make sure that were not losing money and still being able to offer authentic and quality food to our guests, she said.

DeLaCruz also had to change the dining experience, spacing out seating for social distancing, using disposable menus, adding hand sanitizing stations and utilizing outdoor seating set up by Downtown Grand Rapids Inc. for takeout customers.

All staff will be wearing masks. Guests are asked to do so as well when theyre not eating.

We ask that every guest that comes in is also mindful of the staff thats here trying to offer you an experience, she said. That (we) all work together to make sure that were all staying healthy. So thats one of the challenges making sure that were all protecting each other.

Normally, the restaurant could fit 50 people. Coronavirus precautions cut that in half.

Its day by day. I mean, we were at a point where we asked ourself, Are we going to go through this? We thought this was not going to happen. And then they decide to open this (outdoor seating) thing, she said.

While there have been plenty of obstacles, DeLaCruz remains positive and determined to diversify downtown.

There is a lot of opportunities for us to create new things, she said. Grand Rapids is growing and its such a beautiful city that sometimes we lack the movement of making change. So Im here to make a change, to make a difference, to be part of a community and to bring something new to everybody.

Art Caribbean Fusion Cuisine will celebrate its grand opening Thursday with a ribbon-cutting ceremony at 3:30 p.m.

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Art Caribbean Fusion Cuisine brings island experience to downtown GR - WOODTV.com

Being LGBTQ in the Caribbean; Sentencing of transgender woman’s killer throws spotlight on discrimination – Antigua Observer

By Elesha georgeElesha.george@antiguaobserver.comDiscrimination against LGBTQ people in the Caribbean has come under fresh scrutiny following the sentencing of the killer of a transgender woman in Antigua.Arnal Angel Joseph, 25, was stabbed to death in September 2018 by her partner Timothy Jackman, who was last week sentenced to almost 12 years in prison for manslaughter.And while Josephs death was not due to a hate crime, the case has caused residents in Antigua and Barbuda, the Caribbean and internationally to flood Twitter with messages of support for LGBTQ people and the hurdles they face.The sentencing sparked a lively discussion about growing up queer in the Caribbean with Josephs picture posted on various social media sites with the hashtag #sayhername.Voices from across the region openly shared their opinions about the hurdles facing the LGBTQIA which stands for lesbian, gay, bisexual, transgender, questioning, intersex, and asexual community in the Caribbean.Among those tweeting was Antigua and Barbuda Labour Party (ABLP) Senator Aziza Lake who pointed out that black men who identify with the gender they were born as (known as cishet men) but who are queer, have to hide in the proverbial closet.Lake said that men who exhibit what are viewed as feminine traits experience violence and ostracisation, and suggested that transexual women as part of the LGBTQ+ community are more vulnerable because their presence challenges peoples ideas of masculinity.Others shared that they thought being a black queer person conflicts with Christianity a system which has a long history of fighting against and killing them.Sarah-Anne Gresham cofounder of feminist group Intersect Antigua tweeted that shame is a large part of Christian teaching and another example of violence that compounds emotional distress, trauma and self-hatred among what she termed Queeribbean people.One person remarked that they were no longer practicing Christianity because of the shame and conflict it caused them to feel. They also identified Christian colonial ideas as a barrier that prevents the decriminalisation of buggery and the legalisation of same sex marriage within the region.As it relates to violence against other genders, one participant tweeted that it was mentally taxing to go about their day knowing that people are out there who will go out of their way to bring them harm just because they exist differently to others.Many queer persons have a close relationship with depression and anxiety, they tweeted.Another participant this time from St Vincent and the Grenadines said ending general public discrimination, having laws in place to protect queer and transpeople from being victims of hate crimes. Basically seeing queer people as people (worthy of living) can go a long way.Persons also called for Caribbean lawmakers to prioritise decriminalising laws against transgender people, saying that these people have been at the forefront of LGTBQ+ activism but have benefited the least.Further questions and comments spoke of marriage equality, allowing comprehensive sex education inclusive of other genders to be taught at schools, and the psychological impact of violence and discrimination of Queeribbean people.Todays Twitter conversation is actually part of an educational campaign that we initiated this year called the Caribbean Feminist Stories project. We are launching a website where we will be curating Caribbean and Queeribbean feminist stories which will allow people to share their fiction, non-fiction, poetry, and art around different thematic areas, a statement written by Nneka Nicholas and Sarah-Anne Gresham, co-founders of Intersect read.The women explained that they have been sharing infographics on Instagram, excerpts from early submissions, and hosting Twitter chats around various themes.One of them is Growing Up Queer in the Caribbean which, for a lot of people, means fighting every day for their existence to be affirmed and validated and being subjected to violence. The murder of Angel Joseph is a stark reminder that despite people thinking that they dont have it so bad, that isnt the reality, the statement continued.The theme was also relevant because the women believe that it is important to show up for, and celebrate, queer voices while they are still alive and not offer empty condolences after they have been murdered.Transwomen, especially black transwomen, are extremely vulnerable to violence around the world, including the Caribbean. Amplifying the voices of Queeribbean people, especially transwomen, is imperative. The best way to do so is to let them tell their own stories, the statement added.Through this project, the women say they hope to emphasise that transwomen and LGBTQ+ people in Antigua and Barbuda deserve to live in a society where they are cared for, valued, loved, and cherished.Intersect has been advocating for an end to violence against members of the LGBTQIA community since 2015.

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Being LGBTQ in the Caribbean; Sentencing of transgender woman's killer throws spotlight on discrimination - Antigua Observer

Zimbabwe: Churches mediate between government and opposition – Vatican News

The Zimbabwe Heads of Christian Denominations (ZHOCD) meet with political leaders to discuss pressing issues affecting the country.

By Fr. Benedict Mayaki, SJ

The heads of Christian denominations in Zimbabwe have gathered religious and political leaders in a meeting, in the wake of the countrys pronounced socio-economic problems, now exacerbated by the Covid-19 crisis.

In a press statement, the Zimbabwe Heads of Christian Denominations (ZHOCD) said the meeting is part of a series of consultations lined up by the churches to find consensus on the current but also the long-standing challenges facing the nation.

The meeting, which took place last week in Harare, saw representatives from seventeen political parties in attendance. However, representatives from the countrys ruling party, ZANU PF (Zimbabwe African National Union Patriotic Front) were noticeably absent from the meeting.

The ZHOCD reports that participants at the meeting discussed a series of issues affecting the nation.

The participants raised concerns about the current state of the health sector characterized by the protracted strike by medical personnel, especially as the nation battles with increasing Covid-19 cases. They also noted that the resources mobilized for the pandemic were not being satisfactorily put to use.

Another point of unease was the failure to implement the constitution. The Christian leaders and political representatives agreed this has led to an increase in fear among citizens confronted by violence and unresolved cases of abductions and systematic torture at the hands of persons alleged to be state functionaries.

The participants also highlighted the negative effects of the current economic collapse in the country. They pointed out that even the informal economy, which had become the source of livelihood for many citizens, has been destroyed not only by the pandemic, but also because of poor economic policies. In addition, the increase in the level of poverty has further marginalized citizens, especially women and children.

At the same time, the political representatives noted that at the heart of many of the countrys issues is the failure to bring closure to the many hurts and human rights violations of the immediate and long-past, including, but not isolated to,Gukurahundi.They pointed out that due to this wounded past, some communities feel marginalized from national development priorities.

TheGukurahundirefers to a series of killings of mainly Ndebeles in Matabeleland from 1983 to 1987 by military forces. It is estimated that approximately 20,000 civilians were killed. This Shona word Gukurahandi loosely translates as the early rain which washes away the chaff before the spring rains.

In light of these concerns, the participants pointed out that the intertwined and overarching nature of these issues require an urgent, inclusive, broad-based national dialogue process involving political parties, churches, the security and business sectors, among others.

The participants, therefore. requested the collaboration of all stakeholders as these issues can neither be addressed in isolation nor by a few actors.

According to the World Bank, poverty in Zimbabwe rose from 29 percent in 2018 to 34 percent in 2019, with a population increase from 4.7 to 5.7 million people.

Severe droughts in the country, which used to be the breadbasket of southern Africa, have now made it one of the most food-insecure countries in the world.Electricity and water supplies have also been reduced, with widespread rationing.

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Zimbabwe: Churches mediate between government and opposition - Vatican News

President Ilham Aliyev: Armenian leadership needs some kind of crisis to divert thoughts from fundamental issues, and it deliberately resorted to this…

BAKU, Azerbaijan, July 18

Trend:

The Armenian leadership today needs some kind of a crisis to divert thoughts from these fundamental issues, and it deliberately resorted to this provocation, said President of the Republic of Azerbaijan Ilham Aliyev during the meeting of the Cabinet of Ministers dedicated to the results of socio-economic development in the first quarter of 2020 and future objectives, Trend reports.

As for the reasons for the Armenian military provocation, of course, we cannot know them for sure, life will tell. But there are many logical assumptions, and I would like to share my thoughts on this with the citizens of Azerbaijan. I believe that the first reason is the current political and economic crisis in Armenia. This is no secret to anyone. Two years ago, a group funded from abroad, receiving salaries and instructions from foreign funds and using their coup technologies, seized power by illegal means and made many promises. They promised that there would be prosperity and paradise in Armenia. They stated that investments of tens of billions of dollars would be made in Armenia in a short time, the population of Armenia would soon reach 5 million although it is less than 2 million people now, life in Armenia would be rebuilt, there would be justice, democracy would develop, human rights would be protected they made other promises, said President Ilham Aliyev.

He noted that the Armenian people are so disgusted with Sargsyan's regime that they would have believed anyone.

If someone else had organized that coup, the Armenian people would have voted for him as well because the hatred for Sargsyan's regime was enormous. The group that took advantage of this and seized power by force had to fulfill these promises to the end. But how can they do it if there is no experience, competence, domestic resources or foreign investment? On the contrary, today they treat foreign investors with contempt and drag them into litigation. Strategic investors who are helping Armenia stand on its feet are being prosecuted and accused of corruption. They are committing dirty deeds even against companies of the country they are attached to, so to speak. Of course, all of this will scare any potential investor away. If this is how you treat the closest companies that invest in your country, create infrastructure there and provide your people with jobs, then what should investors from other countries think? said President Ilham Aliyev.

The head of state pointed out that therefore, it is natural that the collapse of these promises has already led to the emergence of a crisis in Armenia.

How did the authorities react to this? Instead of uniting society, it actually creates political prisoners, political opponents are detained, prosecuted and deprived of immunity, the constitution is flagrantly violated, illegal amendments that are possible only through a referendum are made to it. They know perfectly well that these amendments will not pass in a referendum. Power has been usurped and there is no division of powers. Power is concentrated in the hands of one person, there is no democracy at all and never has been. What kind of democracy, human rights can we talk about in a fascist state? But the current situation is even more deplorable, because the promises made for the economic sphere were never fulfilled, while from a political point of view Armenia has driven itself into isolation. This was once again confirmed by their silly actions related to the convocation of a special session of the UN General Assembly on the initiative of Azerbaijan. The whole world supported us, only Armenia opposed, said President Ilham Aliyev.

The head of state noted that democratic principles are completely violated in Armenia, recommendations of the Venice Commission are rejected, political opponents are prosecuted and there is a dictatorship.

Therefore, the Armenian leadership today needs some kind of a crisis to divert thoughts from these fundamental issues, and it deliberately resorted to this provocation. Why 12 July? This is also no coincidence. This is being linked to certain events in Armenia now. I do not want to touch on this issue, because I have never touched on family matters and do not advise anyone to do this. But I believe that the main reason for this was the special session of the UN General Assembly, which was officially declared open on 10 July. Because this is yet another huge success, another great victory for our country, as we received the support of 130 countries. Azerbaijan is a country that has drawn attention to the COVID-19 problem that occupies the entire agenda, has held two major summits and after that a special session of the UN General Assembly. This is the reason, said President Ilham Aliyev.

The head of state pointed out that there may be many reasons.

I just want to share my thoughts. The fact is that it is no coincidence that Armenia committed this military provocation at this particular time. But they have received a fitting response. I want to say again that the Azerbaijani army is in full control of the situation. I should also note that although our villages were shelled and an elderly person was killed, none of the inhabitants of our villages budged, not a single person left anywhere. At the same time, according to the operational data we have, people from some villages and cities of Armenia are being evacuated. There is panic there now. This is the difference. The citizens of Azerbaijan live on their land with dignity. The Azerbaijani state and the Azerbaijani army protect and will continue to protect them, said President Ilham Aliyev.

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President Ilham Aliyev: Armenian leadership needs some kind of crisis to divert thoughts from fundamental issues, and it deliberately resorted to this...

Global Food Security Does the Solution for Local Food Production Lie with Israel? – Georgia Today

The COVID-19 pandemic and the ensuing global economic crisis revealed a very troubling fact: the world is unprepared for food security. The complex global systems that were created in the era of accelerated globalization are threatening to collapse: Leading food producers have placed limitations on the export of agricultural goods from their territory, disturbances and interruptions have been encountered along the entire global supply chains from production in the field, to the international marketing of food, the decline in demand and buying-power due to the global economic recession, shortage of farm-hands and the contraction of disease amongst workers in the food-packing factories.

But what is important to emphasize is that we still have not truly distanced ourselves from the danger of hunger and the interruption in the global food supply mechanisms. At the same time, the phenomena of rising food prices, the lack of foreign currency for purchasing food on the global market, market disturbances etc., continue vigorously. Tens of millions of people in the Middle East, Africa, Asia and other areas of the world have joined the 820 million people that, prior to the pandemic, were already defined as under-nourished and in danger of hunger or starvation. The World Bank estimates that approximately 40 million people have entered the category of immediate risk in western Africa alone. UN reports, and first among them, that of the International Food and Agriculture Organization (FAO), warn of a rising threat of hunger, and the UN called upon the international community to maintain open commerce and to refrain from national protectionist policies.

The situation in Georgia is also of considerable concern. According to the UNEP (United Nations Environment Program), land resources are limited in Georgia: only 15% of the country is cultivated, while 70% is forests, bush, meadows and pastures. Agricultural cultivation methods are still largely traditional or unsustainable, which, when combined with climatic and terrestrial conditions, results in the unfortunate fact that more than a third of agricultural land is affected by degradation, erosion, pollution and soil damage. Moreover, around 4% of farmland is vulnerable to desertification. Naturally, that affects food security: Georgia is 70% self-sufficient in vegetables, but only 8% self-sufficient in wheat, according to official statistics.

Just this week, the UN published its annual report on The State of Food Security and Nutrition in the World 2020. According to it, projections show that the world is not on track to achieve Zero Hunger by 2030 and, despite some progress, most indicators are also not on track to meet global nutrition targets. The food security and nutritional status of the most vulnerable population groups is likely to deteriorate further due to the health and socio-economic impacts of the COVID-19 pandemic.

This situation raises the question of what we can do to prevent a global food crisis which may result in hunger, political and security instability and rampant migration. Without doubt, international trade systems for food and agricultural necessities such as fertilizers, machinery, fuel, etc. must be kept open and functioning. At the same time, states would do well if they increased their local food production capacity. This food, in addition to supplying caloric needs, must be healthy, nutritious and available to everyone and at an affordable price. For this, local farming requires significant incentives and support in order to increase its production and variety.

The State of Israel, having proved itself over a period of decades an expert in successful innovative farming in some of the most challenging desert and drought prone areas of the world, can be a supplier of quick, efficient and low-cost solutions for these needs. Drip-irrigation is one of the best examples of this. It is amazing that, to date, most of the agricultural crops the world over are still grown by dry farming, i.e. farming that is reliant on rain for field irrigation. Moving to irrigated farming would increase the crop yield, would save water and greenhouse gases, and would, over time, create food security. Vegetables, for instance, could be grown a number of times during the year via drip-irrigation as opposed to only once a year when relying on natural precipitation during the rainy season.

Precise agriculture, which supplies all plant needs on an almost individual basis, is another example. Today, sensors are capable of informing precisely how much water and fertilizer is required for each tree and from what diseases it is suffering, and accordingly, an individualized treatment which is often administered via drones or other methods. The use of satellites for information gathering and remote sensing, computerized greenhouses and continuous monitoring of temperature, humidity, pests/insects, etc. from afar also increase agricultural crop yields and creates more food.

Everyone knows that without water, nothing can be grown, and in arid Israel, unlimited solutions have been found and implemented, such as the use of purified sewage water for farming, or even the use of saline water, leak prevention and/or the identification of their source in water supply systems, and hydroponics (a form of farming that allows for growing vegetables in water). Water conservation, irrigation monitoring and many other solutions developed in Israel can be implemented relatively easily and at low cost throughout the world.

Among other things, the COVID-19 crisis has also exposed the exaggerated reliance on animal-based food. The closure of slaughter houses and meat packaging facilities, due to the contraction of the disease by their employees, gave a very strong push to the market of plant based substitutes for protein. This industry is seeing an accelerated growth and many technologies such as cultivated meats will begin to see mass use in the coming years. This process will also be accelerated since we know that cultivation of livestock creates heavy damage to the planet and is unsustainable and must therefore be reduced. As a result, the importance of protein sources whose origin is found in plants or cultivated meats, will grow considerably. In Israel, there is extensive research in this area and Israeli startups are on the frontline of the global development of such foods.

The need to strengthen local agricultural produce grows even stronger against the backdrop of the ever-worsening phenomena of climate change, widespread global desertification and water crises, and the extinction of animal and plants species, and with it, huge damage to biodiversity. These and other issues are threatening our ability to supply food over the long term. As a result, there is great importance in preparing ourselves to be able to guarantee food security and for agricultural production by means that do not adversely affect the environment and the climate.

In conclusion, the COVID-19 crisis is still very far from being resolved and we will continue to experience its ramifications in almost every realm of our daily lives. Therefore, it is more important today than ever before to understand the fragility of the global food supply chains, the vulnerability of food security to different sources of disturbance, and to increase local food production wide-scale.

Israel would be both happy and honored to share its rich experience and knowledge in these areas with our Georgian partners. MASHAV (Israels International Development Cooperation Agency) has been operating in Georgia for almost 30 years and has so far trained more than 1,500 Georgian women and men in various professional spheres relating to agriculture, irrigation, entrepreneurship, womens empowerment, public health and numerous other disciplines. The COVID-19 pandemic presents us not only with challenges, but also with fresh opportunities for increasing food security in Georgia and the entire Caucasus. Israel and MASHAV are ready to continue partnership with Georgia (both the public and private sectors) and invest in a better, healthier and safer future for all.

By Ambassador of Israel, Ran Gidor

Isreli water technology innovators share best practices with high-level Indian stakeholders. Source: 2030wrg.org

16 July 2020 17:50

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Global Food Security Does the Solution for Local Food Production Lie with Israel? - Georgia Today

PacBio’s Focus on Human Genomics And Read Length Sweet Spot – Bio-IT World

By Allison Proffitt

July 21, 2020 |It seems like a very long time ago, now, that Illumina and Pacific Biosciences dissolved their merger agreement, but in fact their announcement is just about six months old. Since then, PacBio has been busy reestablishing itself as an independent business and looking ahead, their sights set on the human genome sequencing market.

The dissolution of the Illumina mergercalled off due to the lengthy regulatory approval process and continued uncertaintydid require some back-pedaling. We were actively moving as much as we could without the full regulatory review having completed, Luke Hickey, Senior Director of Strategic Marketing, told Bio-IT World. But Hickey is optimistic about PacBios future.

There was a fairly large breakup fee that ended up giving us significant operating capital, Hickey said of the $98 million termination fee. We have a healthy balance sheet and wereif anythingmore energized to continue as an independent company within the long read space.

As for competitive exposure, Aaron Wenger, Principal Scientist at PacBio, is not worried.

I know that there was some sharing of information, but PacBio has been developing SMRT sequencing for, I think, 20 years, Wenger said. I think there are ways to protect the technology through patents that Illumina can't legally copy, and then also I think many trade secrets that they did not have access to. An added strength, Wenger noted: the many people who could actually execute that on the day to day basis here are still employed at PacBio.

Hickey agreed. We feel like were in an incredibly strong position with the patent portfolio andto Aarons pointhow many years its taken to develop a robust and reliable system for doing the sequencing.

The PacBio sequencing system announced an overhaul itself in 2019. About a year ago, the company launched its Sequel II platform. PacBio shipped 104 Sequel II platforms to customers between June and December 2019, Hickey said, highlighting a healthy mix of existing and new customers. While PacBios historical customers may have focused on microbial or plant and animal sequencing, We have seen just great adoption from the human biomedical market, he emphasized. He name-dropped a few groups to adopt the new platform: the NIHs All of Us program, Mercy Childrens Hospital in Kansas City, Ira Halls group at Washington University in St. Louis, and Evan Eichler at the University of Washington.

The Sequel II system takes advantage of a new read typeHiFi readsthat the company announced in January 2019. The corresponding paper was published in Nature Biotechnologyin August 2019; Wenger is first author (DOI: 10.1038/s41587-019-0217-9). The team optimized circular consensus sequencing (CCS) to improve the accuracy of single-molecule real-time (SMRT) sequencing and generate highly accurate (99.8%) long high-fidelity (HiFi) reads with an average length of 13.5kilobases (kb).

What we were able to do, was significantly increase the efficiency of being able to get multiple observations of the DNA molecule, Wenger explained, through repetitive or circular sequencing of the same DNA. That first time through you detect with 87% accuracy. Then you go around the turn and go back in the other direction and now you get another read thats 87% accurate. But its an independent read from the first one. Now you have two things, each of which are 87% accurate, but you make different mistakes in the two times through. By making multiple observations in series of the same physical DNA molecule, you can generatein softwarea consensus of those passes, he said. If you do 5 passes, you can get 99% accuracy; if you get 8 passes, you get 99.9% accuracy.

The result is highly accurate reads that are opening up new applications.

Our CCS method matches or exceeds the ability of short-read sequencing to detect small variants and structural variants, Wenger and his co-authors wrote in August 2019 paper. De novogenome assembly using CCS reads alone produced a contiguous and accurate genome with a contig N50 of >15megabases (Mb) and concordance of 99.997%, substantially outperforming assembly with less-accurate long reads.

The Sequel II platform enabled researchers to generate the new read type at greater scales than before. By April 2019, at least five early adopter institutions were using Sequel II platforms, and Luke Tallon from the University of Maryland Institute for Genome Services reported seeing, comparable data quality with yields 8-9 times higher than that of the Sequel.

The new platform and read types have been included in several publications including a paper from the PacBio team with scientists from the University of Washington describing improved assembly and variant detection of a haploid human genome published in the Annals of Human Genetics(DOI: 10.1111/ahg.12364). Two additional papers are in review and published on bioRxiv.

Already there have been some interesting trends emerging, Wenger said: some things you would have predicted, and some things we didnt.

Sequencing has labored under a general wisdom, Wenger said, that short, very accurate reads are critical to calling small variants like single nucleotide variants, while do novoassembly required long reads, even with less accuracy. But the HiFi reads, Wenger says, have struck a middle ground. They are accurate and longer (though not as long as longest PacBio reads): about 15,000-20,000 base pairs at greater than 99% accurate.

The question is, how does do these HiFi reads perform compared to either the short or long reads we are used to? Whats interesting is actually seeing thatat least for human genomesthese highly accurate, pretty long reads just significantly outperform even reads that are 100,000 or 150,000 bases long, Wenger says.

A HiFi read that is 20,000 base pairs long and 99% accurate is superior to a 60,000 base pair read that is 85% accurate, Wenger argues. When you call something in the genome a repeat, theyre never 100% identical, he said. If two things are 98% identical in the genome, but your reads are 99% accurate, then you can tell those two things apart. This accuracy lets you resolve more repeats than having long reads.

Wenger says this balance between read length and accuracy is not only scientifically interesting, but also somewhat surprising. At this current point [with the Sequel II], what the platform can deliver is likely enough to completely assemble human genomes from telomere to telomere, he says.

New Applications

There is a group working on that. The Telomere to Telomere Consortiumis an open, community-based effort headed by Adam Phillippy of NIH/NHGRI and Karen Miga of UC Santa Cruz. Their goal is to sequence human chromosomes from end to endincluding tricky centromeresfilling hundreds of gaps across the genome including segmental duplications, ribosomal rRNA gene arrays, and satellite arrays.

We aim to finish these remaining regions and generate the first truly complete assembly of a human genome, the group writes on their website. The ultimate goal of this effort is to drive technology to dramatically increase the throughput of complete, high quality telomere-to-telomere assemblies from diploid human genomes.

At AGBT in 2019 (Feb 27-March 2), Phillippy presented the sequence of the full human X chromosome which was assembled, then iteratively polished with a combination of technologies from Oxford Nanopore, PacBio (both the continuous long reads and the HiFi reads), 10x Genomics/Illumina, and Bionano Genomics. Since then, Wenger says, HiFi has been used to sequence through more centromeres. Now with the HiFi reads, a number of groups have been able to assemble centromeres. Now, I think, theyve assembled nearly half the human centromeres using 15,000 to 20,000 base pairs and 99% accuracy rate, he said. (The sequenced X chromosome was published July 14 in Nature, DOI: 10.1038/s41586-020-2547-7.)

The Human Pangenome Reference Sequence Project is another project making use of the combination of long reads plus accuracy, Hickey added. That project includes researchers from the University of Washington, Washington University and the University of California, Santa Cruz. The two sequencing centersUniversity of Washington and Washington Universityare using the PacBio HiFi reads as the primary sequencing technology for assembly, Hickey said. The group will also use Oxford Nanopore for scaffolding work. The group has done 30 human reference genomes this year, Wenger addeda huge increase from output in the past.

Sweet Spot

The Sequel II and HiFi reads mark a shift in PacBios technical focus moving forward. Wenger says that 20,000 bases is, likely sufficient for anything youd want to do in a human genome, so pushing for longer read lengths isnt a priority. There are still a few centromeres that have to be finished, so maybe youll need 30,000 for those. But Im kind of skeptical. I think that 20,000 is going to be plenty and that its just continued algorithmic improvements that will take it the rest of the way, he said.

He also pointed out a practical reason that 20,000 base pairs is an ideal read length. We found that the 20,000 base-pair-range is the comfortable range where people can collect samples, consistently process them, and generate good libraries at that read length. When you try to push to more extreme read lengths, there become a lot more limitations on sample collection and libraries fail a lot more. Thats not a problem with the sequencing technology, thats a problem with the upstream DNA handling.

Hickey agreed. The next step for us is not necessarily to drive up read lengths, because we think that is sufficient, but to drive down the cost. Thats our roadmap for 2020 We are trying to get to one human genome, on one SMRT cell, in one day. For just over $1,000 in consumable costs, Hickey points out, and could give you, all of the answers you want.

Hickey sees clinical utility in the platforms future. The NIH-funded research has an eye toward eventual clinical applications and he mentions a HudsonAlpha group exploring the Sequel II for diagnostics.

As those studies get published, that will really set us up for maybe more of push into the clinical market for using the whole genome sequencing with HiFi in a more routine way, Hickey said. But certainly for the next few years, well be in this basic human genetics research, and then all of this translational, clinical, exploratory research realm to demonstrate utility.

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Staten Biotechnology, in collaboration with Novo Nordisk, starts dosing of anti-apoC3 antibody SST-5058 in First-in-Human Trial | Antibodies | News…

DetailsCategory: AntibodiesPublished on Tuesday, 21 July 2020 11:10Hits: 179

Clinical trajectory initiated towards development of novel treatment for dyslipidaemia

NIJMEGEN, The Netherlands I July 21, 2020 I Staten Biotechnology B.V. announced today the initiation of dosing of the Companys lead asset, STT-5058, in a First-in-Human clinical study.

STT-5058 is a monoclonal antibody that targets the lipoprotein ApoC3 and is being developed in collaboration with Novo Nordisk. Staten Biotechnology and Novo Nordisk entered a collaboration and exclusive option agreement in December 2018 to develop novel therapeutics for the treatment of dyslipidaemia. Novo Nordisk is providing funding and support to Staten for the development of STT-5058 in this indication.

Hilde Steineger, CEO of Staten Biotechnology, said: Staten Biotechnology, with great support from Novo Nordisk, has been able to rapidly progress from research to product manufacturing to a clinical trial for our lead drug candidate. We are very excited to dose the first healthy volunteer.

Professor John Kastelein, Chief Medical Officer of Staten Biotechnology, added: The commencement of the FIH trial is an important milestone for the Company. We believe STT-5058, based on its favourable safety profile and novel mechanism targeting ApoC3, which is supported by human genetics, has the potential to address an unmet medical need in patients with mixed dyslipidaemia and high cardiovascular risk.

About Staten Staten Biotechnology B.V. aims to develop novel and innovative strategies for the treatment of dyslipidaemia, with a focus on hypertriglyceridemia treatment. BioGeneration Ventures (BGV) provided the companys seed financing in 2014 and Forbion led the Series A round, as the sole new investor. Staten is a prime example of Forbions and BGVs company building activities, growing great scientific ideas into promising companies. For further information: http://www.statenbiotech.com

About STT-5058 STT-5058 is a humanized, monoclonal antibody targeting novel and unique epitopes on apoC3. This recycling antibody with extended half-life has the potential to lower triglyceride levels and increase clearance of ApoC3-containing atherogenic particles. Multiple studies have identified ApoC3 levels to be inversely associated with a favourable lipid profile and insulin resistance, both key components in managing residual cardiovascular risk. This antibody was licensed from Statens research collaboration partner argenx and is developed in collaboration with Novo Nordisk.

About ApoC3 ApoC3 is a small apolipoprotein that inhibits the uptake of lipoprotein particles by the liver and inhibits the activity of lipoprotein lipase leading to high levels of lipoproteins and triglycerides. It is secreted from the liver and small intestine and circulates on both triglyceride-rich lipoproteins such as very-low-density-lipoproteins (VLDL), chylomicrons in addition to high-density lipoproteins. Population groups with loss-of-function mutations in apoC3 have reduced incidence of vascular and heart diseases. High levels of apoC3 correlates with higher amounts of triglycerides and increased incidence of vascular and heart disease. This supports the potential of the anti-apoC3 antibody to act as key molecule in dyslipidemia management.

SOURCE: Staten Biotechnology

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FDA Action Alert: Jazz, ANI and Ultragenyx – BioSpace

Wrapping up the month of July, there are three PDUFA dates on the U.S. Food and Drug Administration (FDA) calendar, although one of the drugs has already been approved and another company is in the process of refiling their application. Heres a look.

Jazz Pharmaceuticals Drug for Cataplexy

Jazz Pharmaceuticals has a target action date of July 21 for its New Drug Application (NDA) for JZP-258 for cataplexy or excessive daytime sleepiness (EDS) in patients seven years of age and older with narcolepsy. The drug is a novel oxybate product with a unique composition of cations resulting in 92% less sodium than Jazzs Xyrem (sodium oxybate).

At this time, Xyrem is the only product approved to treat both cataplexya sudden loss of muscle tone with retained consciousnessand EDS in patients with narcolepsy ages seven years and older.

We developed JZP-258 to be a safer and long-term treatment option for patients, said Robert Iannone, executive vice president, research and development of Jazz, back in March when the FDA accepted the NDA application. JZP-258 represents between 1,000 and 1,500 milligrams daily reduction of sodium for patients currently treated with Xyrem, depending on the dose. Given the broad scientific consensus that reducing daily sodium consumption is associated with clinically meaningful reductions in blood pressure and cardiovascular disease risk, we believe that JZP-258 has the potential to be an important treatment option for patients living with the life-long condition of narcolepsy. Narcolepsy patients are known to be at increased risk of comorbidities, including obesity, hypertension, diabetes and dyslipidemia.

ANI Pharmaceuticals Purified Cortrophin Gel Prior Approval Supplement

ANI Pharmaceuticals had a target action date of July 23, 2020, for its supplemental new drug application (sNDA) for Purified Cortrophin Gel (Repository Corticotropin Injection USP). In an announcement in March, when it submitted the sNDA, the company noted the current annual market for the drug is about $950 million and there is only one competitor.

Cortrophin Gel was originally approved by the FDA in 1954 and halted use in the 1980s. The drug has more than 54 indications in its previously approved label, including acute exacerbations of multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus and ulcerative colitis. The company acquired the NDA from Merck in January of 2016 and spent more than four years and over $100 million to re-establish and validate the commercial corticotropin active pharmaceutical ingredient and the drugs manufacturing processes. This included rebuilding a U.S.-based supply chain.

On April 28, the FDA issued a Refusal to File (RTF) letter regarding the sNDA. The FDA said on preliminary review, certain portions of the Chemistry, Manufacturing and Controls section were not sufficiently complete to permit a substantive review. On June 1, ANI provided an update and indicated it plans to refile the sNDA when it completes the review process.

Ultragenyx Pharmaceuticals UX007 for Long-chain Fatty Acid Oxidation Disorders

Ultragenyx Pharmaceuticals has a target action date of July 31 for UX-007 for long-chain fatty acid oxidation disorders (LC-FAOD). On June 30, the FDA approved UX007 (triheptanoin) under the trade name Dojolvi.

LC-FAOD are a group of rare, lifelong and life-threatening genetic disorders. In them, the body cannot convert long-chain fatty acids into energy. Dojolvi is a highly purified, synthetic, 7-carbon fatty acid triglyceride designed to provide medium-chain, odd-carbon fatty acids as an energy source and metabolite replacement for LC-FAOD patients. When people are born in the U.S. and certain European countries, LC-FAOD is included in newborn screening panels because of the risk for serious health issues, including early death. The current treatments include avoiding fasting, low-fat/high-carbohydrates diets, carnitine and even-carbon medium-chain triglyceride (MCT) oil, a medical food product. These diseases affect about 2,000 to 3,5000 children and adults in the U.S.

FDA approval of Dojolvi for the treatment of long-chain fatty acid oxidation disorders is a huge milestone for patients and their families, as it is the first such medication, said Jerry Vockley, Professor of Human Genetics and chief of Medical Genetics at Childrens Hospital of Pittsburgh of UPMC. While we have been able to identify these disorders at birth for many years, treatment options have been limited. Dojolvi brings hope as a new tool now available to clinicians taking care of these patients.

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FDA Action Alert: Jazz, ANI and Ultragenyx - BioSpace

Coronavirus is not mutating to be weaker over time, genetics show – Business Insider – Business Insider

People wear face masks as they attend the live broadcast of Pope Francis' Sunday Angelus prayer at Saint Peter's Square in Vatican City, March 8, 2020. Antonio Masiello/Getty Images

Experts continue to throw out conflicting ideas about whether the coronavirus has changed. Some Italian doctors say it's gotten weaker over time. A group of researchers has suggested the opposite: that a mutated version of the virus became dominant worldwide because it's more transmissible than the original.

All viruses, including the coronavirus, change over time by accumulating mutations as they replicate. But according to Emma Hodcroft, a geneticist at the Nextstrain project, there's still no evidence this virus changed in any significant way not to become less deadly, and not to be more contagious.

The Nextstrain project has been tracking changes in the coronavirus for months. So far, Hodcroft's team has collected and sequenced the genome of thousands of virus samples collected around the world since December 2019.

Geneticists differentiate these samples into five clades the term for groups of virus samples that have descended from a common ancestor characterized by mutations that have accumulated over time in one or more of a dozen genes.

But none of those mutations have meaningfully changed how lethal or infectious the coronavirus is, Hodcroft said.

It's easy to think that humanity's attempts to control the coronavirus's spread via social distancing, mask wearing, and lockdowns may have applied evolutionary pressure on the virus. Given impediments to its spread, this line of logic suggests, perhaps the virus might evolve to improve how it passes between people.

But according to Hodcroft, the virus has no significant impetus to change right now.

"The virus is very successful at what it's doing most people who get infected don't die. They pass along the virus to a new host and recover," Hodcroft said. "It's current strategy has helped it cover the whole world in months."

People wearing masks wait on a crowded subway platform on May 30, 2020, in New York City. Alexi Rosenfeld/Getty Images

If the original strain of the coronavirus killed its host within a few days, then perhaps it might have mutated over time to not kill as quickly, she added that would give it more opportunities to jump to new hosts. But on average, people die of COVID-19 18 to 19 days after symptoms start, according to a study from Wuhan, China.

Alternatively, if social distancing were having an effect, Hodcroft said, the coronavirus might mutate to become more infectious "to overcome barriers we put in its way."

Research has in fact shown that a mutated coronavirus strain became dominant worldwide one that appears to be more transmissible between human cells than the original virus. But Hodcroft said the strain might simply have gotten lucky, since it ended up being the version that spread to countries in Europe and North America. Many of those countries did not enact lockdowns for weeks after their first cases appeared, which allowed that version of the virus to proliferate.

Plus, scientists still aren't sure whether observations at the cellular level apply to real people.

"We don't know how things we see in a lab scale up to a size of a full human. Transmissibility in cells and people are completely different ballgames," Hodcroft said.

An artists's rendering of the coronavirus. Corona Borealis Studio/Shutterstock

She added that such mutations, though possible, "happen over decades or centuries."

In a June op-ed, 10 Italian doctors suggested that the coronavirus was weakening and had changed to be less lethal.

The "virus from the clinical point of view no longer exists" in Italy, they wrote, citing a marked reduction in symptomatic coronavirus cases and hospitalizations. The op-ed also noted that viral loads how much of the virus is present in swabs from many Italian patients were so negligible that patients were not even contagious.

"The concentration of viral RNA on the swab is so small that it does not infect anything," Giuseppe Remuzzi, one of the op-ed co-authors, told Politico last week.

A hospital employee wearing protective gear shows a cotton swab for taking a coronavirus sample. Miguel Medina/AFP via Getty

But Hodcroft said"there isn't any validity to those claims."

In fact, she added, it's "misleading for Italian doctors to say this when they're looking at only Italian patients."

Michael Ryan, the executive director of WHO's Health Emergencies Program, similarly warned in June: "We need to be exceptionally careful not to create a sense that all of sudden the virus, by its own volition, has now decided to be less pathogenic. This is still a killer virus."

Nurses transport a COVID-19 patient in a biological containment stretcher in the Da Procida Hospital in Salerno, Italy, in April. Ivan Romano/Getty Images

The more likely explanation for the trend the Italian doctors have observed, Hodcroft said, is that in March, Italy's healthcare system was strained, so most patients admitted to the hospital had very severe cases. At that time, about 6,500 new cases were being reported per day in Italy. But by the end of May, the number had dropped to about 300. That may have enabled more Italians with milder cases to get care, which could explain the lower viral loads in swab tests.

Indeed, two studies found that people who develop more severe respiratory issues linked to COVID-19 have higher viral loads when admitted to the hospital relative to people with mild cases.

"As the pandemic slows down, more of the general population is getting tested, so you'll probably pick up more people with mild symptoms," Hodcroft said. "If you don't account for that, that could lead you to believe the virus has become less severe."

Adam Payne contributed reporting to this story.

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Coronavirus is not mutating to be weaker over time, genetics show - Business Insider - Business Insider

Humanized Mouse Model Market Key Players are Aggressively Investing on Research and Development – BioSpace

TMR Research speaks on the core issues and characteristics of the global humanized mouse model market, along with its nuances and opportunities of growth over the coming years, in Humanized Mouse Model Market Global Industry Analysis, Size, Share, Trends, Analysis, Growth, and Forecast 2017 2025.

The leading factor augmenting the growth rate of the global humanized mouse model market at the moment is the high demand posed by the pharmaceutical industry. The prevalence of diseases has been on the rise over the years and the healthcare and pharmaceutical industry are hard pressed to find optimal solutions for the incoming waves of both new and old diseases. This is creating a very high demand for humanized mouse models, especially in the pharma business, where research benefits massively through the use of mice that are integrated with human DNA, microbiomes, tumors, or tissue. The mice also hold a high value in the fields of genetics and drug development.

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National governments are also playing an important role in the overall development of the global humanized mouse model market through increasing incentives and investment initiatives. The growing number of incentives and grants received by the leading players in the market is expected to propel the global humanized mouse model market over the coming years.

The genetic models segment is expected to show the greater demand volume in the global humanized mouse model market over the coming years, above cell-based humanized mouse models. This demand is speculated to rise due to the increasing scope of applications that genetic model mice will hold.

Geographically speaking, the global humanized mouse model market can be segmented on the basis of the key regions involved. North America has been leading the market over the recent past, thanks to an advanced pharmaceutical infrastructure where investments for research and development are very high. It is likely for North America to remain in the lead over the coming years. Meanwhile, the booming healthcare and pharmaceutical infrastructure across Asia Pacific is expected to provide a massive surge to the global humanized mouse model market in the immediate future.

The leading players in the global humanized mouse model market, at the moment, include Horizon Discovery Group PLC, genOway S.A., Axenis S.A.S, ingenious targeting laboratory, HuMurine Technologies, Inc., Harbour Antibodies BV, and The Jackson Laboratory. The competitive landscape of the market is such that the leading entities are extremely focused on investing more in research and development. At the same time, they are interested in improving their professional profile through mergers and acquisitions.

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The widespread drive for humanized mouse models has stemmed from the substantial need for robust pre-clinical animal models for the study of a spectrum of human diseases. These animal models are proving to be promising in closely reflecting human biological systems. The rising clinical use of humanized mice in expanding our understanding of cancer therapies, regenerative medicine, allergies, and immunity-related diseases is propelling the growth of the market.

To shed in-depth light on such trends and factors influencing the growth trajectory of the market, TMR Research has published a new report, titled, Humanized Mouse Model Market Global Industry Analysis, Size, Share, Trends, Analysis, Growth, and Forecast 20172025.

The attractive demand for humanized mice models for pre-clinical tools for biomedical research to discover more efficacious drugs is boosting the market. The rise in strategic mergers and acquisitions entered by pharmaceutical companies in various parts of the world to boost drug discovery activities is fortifying the demand for these cutting-edge platforms. The sizeable funds and grants committed by governments in several countries for research and development activities related to humanized model is providing a robust catalyst to the demand.

The growth of the humanized mouse models market is expected to reflect well from the rising efforts by pharmaceutical and biotech companies in personalized medicines. The growing adoption of mouse models with humanized immune systems to act as in vivo platform for assessing the efficacy of new drugs is also propelling the markets growth. They prove to be useful in-vivo models for graft rejection research. Furthermore, the notably rising demand for cell-based humanized mouse models in genetic studies world over is accentuating the market.

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Some of the prominent players holding a substantial stake in the global humanized mouse models market are The Jackson Laboratory, Harbour Antibodies BV, HuMurine Technologies, Inc., Ingenious Targeting Laboratory, Axenis S.A.S, GenOway S.A., and Horizon Discovery Group PLC.

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The Villages in Florida and the coronavirus – Boston.com

THE VILLAGES, Fla. For months, many of the residents at one of Americas biggest retirement communities went about their lives as if the coronavirus barely existed. They played bridge. They held dances. They went to house parties in souped-up golf carts that looked like miniature Jaguars and Rolls-Royces.

And for months they appeared to have avoided the worst of the pandemic. From March through mid-June, there were fewer than 100 cases in The Villages, a sprawling community in Central Florida where about 120,000 people mostly 55 and older live.

But now as cases spike across Florida, the virus appears to have caught up with the residents of The Villages.

Since the beginning of July, hospital admissions of residents from The Villages have quadrupled at University of Florida Health The Villages, the hospitals critical care doctors said. As of last week, the hospital admitted 29 Villages residents, all of them with the virus, said Dr. Anil Gogineni, a pulmonologist and critical care doctor there. That was up from the single digits three weeks before.

In Sumter County, the biggest of three counties where most of The Villages is concentrated, the number of cases ballooned from 68 in the first week of June to more than 270 last week, according to the countys Health Department.

The Villages is a sprawling palm-tree-lined complex so big it has three ZIP codes, 55 golf courses and multiple libraries and movie theaters, drawing affluent retirees from all over the country.

Now many residents are confronting their new reality. Its seeping in, no matter what, Rob Hannon, 64, said as he sipped a beer, adding that friends that would come down for years are saying, Were not going to go.

The golf course is still crowded, he said, as well as the hair salon where his wife, Michelle, 53, works. The women are still coming in but theyre a little more anxious, Rob Hannon said. You cant stop living. But you can stop being cavalier.

In an email to residents last week, Jeffrey Lowenkron, the chief medical officer of The Villages, said cases were increasing and urged them to take proactive steps to reduce the risk of disease transmission.

They should consider postponing participation in social events with more than 10 people, particularly those events held indoors, he wrote. The upward trend is accelerating.

That The Villages had initially seemed to escape the worst of the virus had been a point of pride for Gov. Ron DeSantis. The governor, a Republican who has strong support from the community, brushed off concerns about the risks during a visit in April. There were articles written saying, Oh, The Villages is going to crash and burn, he said. They have like a 2% or 2.5% infection rate.

But when he returned early in July, the infection rate had jumped to 9%.

More than a third of the cases in the state, one of the worst hit in the nation, have been among people ages 15-34, particularly in big cities, according to the Florida Department of Health. There have been serious outbreaks since the beginning in jails, nursing homes and farms.

Now there are signs that the age of Floridians getting the virus is shifting. Jackson Health System, Miami-Dade Countys public hospital, said last week that 18% of its coronavirus patients were 80 or older. Two weeks before, that figure was 9%.

About 20% of Floridas population is 65 or older, the highest percentage in the nation alongside Maine, and that age group has made up half of its coronavirus hospitalizations and over 80% of deaths. As of Saturday, more than 45,000 of the states 350,000-plus cases are among that age group.

The rise in cases among older residents most likely stems from the spread of the virus by young people who are not taking preventive measures like wearing masks, said Dr. Madiha Syed, an infectious-disease specialist who works at University of Florida Health.

You see, they dont wear their masks, Syed sighed. What do you do?

But even as cases climb, doctors in The Villages say they are prepared for an increase in patients. The hospital has enough capacity and antiviral drugs, Gogineni said.

One area of concern, however, is the four nursing homes in the community, and a number of others on the outskirts that also cater to residents.

Early in the pandemic, DeSantis took an aggressive approach to nursing homes, and the states outbreaks were not as deadly as they were in places like New York. DeSantis banned visits to nursing homes, ordered them to not readmit residents unless they tested negative twice, and opened at least 14 coronavirus-only facilities.

That helped slow the spread, but now health officials are concerned that nursing homes will not be able to avoid a coming onslaught of cases.

Lady Lake Specialty Care, which sits just outside The Villages boundaries and cares for some of its residents, reported 47 cases last week, according to Greystone Healthcare Management.

In the latest effort by the Florida government, the Agency for Health Care Administration last week issued a pair of emergency rules mandating that every nursing home and assisted living facility in the state test staff members every two weeks. (The rules do not apply to long-term care facilities.)

DeSantis on Wednesday said that more than 120,000 staff members of nursing homes and assisted living facilities have been tested during the past week, about 2.8% of whom were positive. We are actually happy with that, he said. Still, he played down a recent outbreak at an unnamed long-term care facility in north-central Florida where 50 staff members had tested positive.

Even with the spike, many residents at The Villages say they are conflicted about the virus and what to do now.

Some steps have been taken to help slow infections. Crowds around the faux Spanish colonial buildings and fountains are smaller, theaters are closed and the bands have stopped playing.

Yet, residents still congregate every day without wearing masks. They turn up the volume on a radio and dance in the squares. They crowd bars where songs by Elvis Presley and Bobby Sherman play. There are picnics and water aerobics classes.

Jim Lomonaco, 67, a former law enforcement official, shrugged off the latest headlines.

Im not pushing my luck but Im not overly concerned. If its here, its here by now we dont have walls, he said on a recent day. Bursts of loud laughing were heard from other retirees clustered around tables at a nearby restaurant. A few feet away, dozens of others were practicing a dance.

Don Phillippi and his partner, Flo Collins, both 79, sat watching in their golf cart, which many in The Villages call a golf car.

Collins, a retired nurse, said the couple wore masks when grocery shopping, and mostly stayed indoors playing card games. Im a nurse, so I know, she said.

The only time they socialize is when they celebrate a birthday with friends at a restaurant. But well have a private room, Phillippi insisted. And we take the temperature and all that kind of stuff. To make sure everybody is OK.

Even if they have had the virus, most Villages residents are reluctant to talk about it.

One resident declined to be interviewed because he was embarrassed after getting infected at a party.

People are being very secretive, said Neil Craver, 66, who said he got the virus two weeks ago. Its like the plague and they dont want to let anybody else know that theyre sick.

Residents say they have not received any directions about informing the management if they get sick.

About two-thirds of the residents are Republicans, according to local party chairs, and like elsewhere, some precautions are drawn politically.

You can tell who is a Democrat, who is a Republican by their masks, said Chris Stanley, the leader of The Villages Democratic Club.

It makes no sense to me that there is some sort of a magical umbrella keeping the virus at bay, particularly because people are having parties around, with houses that have six, five golf cars parked out front, she said.

Amy Rose, a Villages resident, lost her husband, Chad, a lab technician at one of The Villages hospitals, to what she believes was the coronavirus. His death, however, was recorded as a heart attack.

She and her husband both had coronaviruslike symptoms in January after visiting Disney World when the virus raised little concern in the United States. In April, Rose, 47, who had a heart condition, suddenly collapsed after exercising.

Roses cardiologist told her the coronavirus had likely contributed to his heart attack by narrowing the arteries. They said that because he had that history of a heart attack they didnt do the autopsy. They just declared it.

His death was very violent, she said, breaking down in tears. It was awful.

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The Villages in Florida and the coronavirus - Boston.com

Dozens tested on Long Island for COVID-19 got false positives – Newsday

Seventy-four Long Island residents testedfor COVID-19 over a five-day period earlier this month received false positive results, according to Nassau and Suffolk counties.

Sunrise Medical Laboratories in Hicksville said in a statement that the isolated incident does not impact any patients who received a negative result during that time or testing performed at any other time or by any other facility.

The impacted patients were tested between July 9 and July 14, according to the lab, which added that about 1.5% of patients tested in that period were affected. Sunrise did not saywhich doctors or urgent care centers usetheir labs. It added that there was a "possible COVID-19 specimen contamination issue."

Corrected reports were issued to providers caring for all affected patients on July 16 and 17, 2020, the lab said in a statement. After extensive consultation with the New York State Department of Health [NYSDOH], and out of an abundance of caution, we are offering retesting to all patients receiving the corrected report at no charge. We are currently working with providers to reach out to the affected patients and complete the retesting as soon as feasible.

Suffolk County said about 68 residents were affected. Suffolk, for now, is still treating the cases as positive.

"Out of an abundance of caution, the [Department of Health] will still treat them as positive cases until the 14-day window to become symptomatic concludes or they test negative," Derek Poppe, a spokesman for County Executive Steve Bellone, wrote in an email. "Our contact tracers will still follow up with them daily to check in."

Nassau County spokesman Michael Fricchione said the county's department of health is aware of the six residents notified of receiving false positive test results from the private laboratory, and is in contact with these residents."

There have been other reports nationwide of testing errors. For example, the Connecticut Department of Public Health said Monday that the state laboratory found mistakes in the testing system that led to 90 false positives. Connecticut said many of the false positives were for nursing home residents.

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Over the weekend, Vermont officials said at least 30 patients also received false positive results.

Dr. Dwayne Breining, executive director of Northwell Health Labs, said false positives become a risk asmore asymptomatic people are tested for COVID-19.

"Molecular testing is so sensitive," Breining said. "We've had a very small number of false positives as well. I can probably count them on one hand, but when it happens, we retest, and ask the person to isolate while we retest them and investigate."

Breining added that a vast majority of the test resultsare accurate.

But COVID-19 tests are not perfect, in part, because the virus itself is new, said Alvin Tran, professor of public health at the University of New Haven in West Haven, Connecticut.

"There is no gold standard diagnostic test yet," Tran said. "But news like this shouldn't deter anyone from being tested, especially if they have symptoms."

Howard Austin, 56, of Smithtownsaid he was among those who received false positives from Sunrise,and was then asked by state contact tracers to quarantine until he got a follow-up message that was confounding.

I received a call from Sunrise saying that I was actually negative, Austin said. I was stunned. I went a full week thinking I was positive.

Austin said his daughter was also tested, but her test came back negative. Austin added that his patient portal has been updated to reflect he tested negative for COVID-19.

David Reich-Hale reports on the business of health care, banking and other topics. He joined Newsday in 2014. He has also worked at American Banker and the New Haven Register. He is from Trumbull, Connecticut.

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Dozens tested on Long Island for COVID-19 got false positives - Newsday

From reopenings to masks, how Georgia Gov. Kemp has handled the coronavirus pandemic – ABC News

Since officials announced Georgia's first confirmed cases of COVID-19 on March 2, the state has drawn national attention over the coronavirus pandemic. It was one of the first states in the country to begin reopening its economy, and has since joined others in pausing its phased approach amid rising numbers of new cases and hospitalizations.

Most recently, its Republican governor, Brian Kemp, has become engaged in a legal dispute with the mayor of Atlanta over mask mandates, which more states and cities have been issuing as coronavirus cases rise.

As of Monday, Georgia had 145,575 confirmed cases of COVID-19 and 3,176 deaths, according to state data. Hospitalizations have also steadily increased since mid-June. The state reported a record number of new COVID-19 cases on Saturday, with 4,689.

Here's a look at some of the key moments in Kemp's handling of the coronavirus pandemic so far.

With COVID-19 spreading around the globe, including in the United States, Kemp announces the creation of a coronavirus task force to assess the state's preparedness in addressing the virus.

In a late-night press conference, Kemp announces Georgia's first cases of COVID-19, involving two residents of Fulton County in the same household, one of whom had recently returned from Italy. The state health department later determines that Georgia had cases as early as Feb. 1.

Governor Brian Kemp holds a press conference at the Georgia State Capitol in Atlanta, July 17, 2020.

The governor directs state agencies to implement teleworking policies and suspend nonessential travel for most state employees. The same day, the state reports its first death from COVID-19 -- a 63-year-old man who had underlying medical conditions. Later, the health department updates its data to report that the first death was on March 5.

With 64 confirmed cases of COVID-19 in the state, Kemp declares a public health state of emergency. He also authorizes up to 2,000 National Guard troops to assist in the emergency response.

Kemp signs an executive order closing all elementary, secondary and post-secondary public schools from March 18 to March 31.

Per federal and state health officials, Kemp urges that the state start prioritizing COVID-19 tests "for our most vulnerable populations," first responders and healthcare workers, in an effort to conserve hard-to-find medical supplies.

People stand in line to get tested for COVID-19 at a free walk-up testing site on July 11, 2020, in Atlanta.

An executive order goes into effect closing all bars and nightclubs, banning gatherings of 10 or more people unless social distancing is in place, and requiring at-risk populations to shelter in place for two weeks.

Schools are closed through the end of the school year. At a coronavirus press briefing, Kemp draws ridicule after saying that he only recently became aware that asymptomatic people could spread the virus.

A statewide shelter-in-place order goes into effect, issued as the state reports more than 4,600 confirmed COVID-19 cases.

Kemp signs executive orders extending Georgia's public health state of emergency through May 13 and activating 1,000 more National Guard troops. He also extends the statewide shelter-in-place order through the end of the month.

The state expands testing criteria to include symptomatic critical infrastructure workers and asymptomatic people who have had direct contact with positive COVID-19 patients. In a statement, Kemp says, "Our testing numbers in Georgia continue to lag."

The governor also signs an order suspending enforcement of Georgia's anti-mask statute "so people can follow the guidance of public health officials without fear of prosecution," Kemp says, adding, "I want to thank Atlanta Mayor Keisha Lance Bottoms for raising awareness about this issue."

Kemp announces the completion of a 200-bed alternate care facility at the Georgia World Congress Center to provide treatment to non-critical COVID-19 patients.

In the wake of new reopening guidelines released by the White House, Kemp announces that he will let his shelter-in-place order expire on April 30 and allow some nonessential businesses to reopen, starting with gyms, bowling alleys, hair salons, barbershops, nail salons and other similar businesses on April 24 and restaurant dine-in service on April 27. The move draws criticism, including from President Donald Trump, who says, "I think it's too soon."

In this April 24, 2020, file photo, barber Tommy Thomas gives his long-time customer Fred Bentley a haircut after the Georgia governor allowed a select number of businesses to open during the COVID-19 restrictions in Atlanta.

On the day the statewide shelter-in-place order expires, Kemp extends the public health state of emergency through June 12 "to continue enhanced testing across Georgia, ramp up contact tracing, and maintain effective emergency response operations in every region." Vulnerable populations are also ordered to continue to shelter in place through June 12.

The governor renews the state of emergency for a third time, through July 12. On the same day, he loosens public gathering restrictions up to 25 people and announces more reopenings, including bars and nightclubs starting June 1 and amusement parks and water parks starting June 12.

Kemp rolls out more reopenings, including live performance venues starting July 1, and increases limitations on gatherings to up to 50 people with social distancing in place.

Kemp extends the public health emergency through Aug. 11 as the state "has seen an increase in new cases reported and current hospitalizations." An ABC News analysis finds that Georgia has recently seen record numbers of new cases.

The governor announces he is reactivating the Georgia World Congress Center, which had discharged its last patient in late May. That day, the state reports a record number of new coronavirus cases, with 4,484.

Three days after Bottoms announces that Atlanta is reverting to "Phase One" due to rising cases in the city, Kemp releases a statement that the action is "non-binding and legally unenforceable" and asks residents to follow his orders.

Atlanta Mayor Keisha Lance Bottoms appears on "Good Morning America," July 7, 2020.

Kemp voids at least 15 local mask mandates, including those in in Atlanta, Augusta, Savannah and Rome, instead encouraging voluntary mask wearing in the state.

Kemp sues the city of Atlanta over its requirement to wear masks in public. "Governor Kemp must be allowed, as the chief executive of this state, to manage the public health emergency without Mayor Bottoms issuing void and unenforceable orders which only serve to confuse the public," the lawsuit states.

Tune into ABC at 1 p.m. ET and ABC News Live at 4 p.m. ET every weekday for special coverage of the novel coronavirus with the full ABC News team, including the latest news, context and analysis.

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From reopenings to masks, how Georgia Gov. Kemp has handled the coronavirus pandemic - ABC News

U.S. Reports More Than 70,000 New Coronavirus Cases for the Second Time – The New York Times

michael barbaro

Hey, there. Its Michael.

This week, were revisiting people we met in the early weeks of the pandemic, listening back and hearing whats happened to them since our original conversations.

Today: Tilly Breimhorst.

Its Friday, July 17.

(SINGING) I am recording and it is working. Hey, Tilly?

Hi.

Hey, how are you?

Im doing OK.

Tilly, what is that in your hand? It looks like a blanket or a stuffed animal.

Its a blanket.

Oh, what does it say on it?

It says powered by pizza.

And does it look like it has an image of pepperoni pizza on it? Is that Im glimpsing?

Yeah, pepperoni.

Thats pretty great. Well, Tilly, I really want to thank you for getting on the phone with us, or I guess this Google Hangout with us. And I wonder if you could tell me your full name and how old you are?

Matilda Rose Breimhorst, and then I am 12.

Mm-hm. And I just want to start with a very simple question: How have you been feeling this past week?

Um, Im kind of in and out of moods usually. The two moods that Im mostly in are sad and angry.

And why do you think that youre sad and angry? What about?

I dont know were I feel like were sad and angry because I think angry more that its not fair that hes gone. And I feel like sad is really were sad that hes gone and sad that were being sad.

From The New York Times, Im Michael Barbaro. This is The Daily.

More than 50,000 Americans have died from the coronavirus. One of them was Craig Breimhorst.

Today, his granddaughter remembers him.

Its Friday, May 1.

I wonder if you could tell me a little bit about your grandfather. How would you describe your grandfather physically? What did he look like? What would he wear, those kind of things?

Um, well, hed wear pastor clothes and stuff.

Was he a pastor?

Yes, he was a pastor. He used to be a mail man, and then he didnt like that job.

Mm.

And he had white hair, and then the mustache that goes right into the beard.

Mm-hm.

And when I was little, I played with his beard because it just felt so interesting touching it with my hands.

What do you mean?

It felt all rough and scrapey, but like not too scrapey.

Hed wear glasses, and sometimes I stole his glasses. And he was like, Tilly, bring them back! And, like, whenever I walked into the house, hed just be like, Hoddy ho! I dont know where that came from, but it was just its always something he said.

Hoddy ho?

Hoddy ho.

Its more interesting than hello.

Yeah.

Did he have any kind of nickname for you?

Tilly B was my one.

Tilly B?

Yeah, cause for Breimhorst. They just called me Tilly B and and it kind of just rhymes.

Wait, what part? Which part rhymes?

Tilly, and then B. Its just kind of, like, it just goes together.

Hm.

Tilly B.

Tilly B.

Yeah.

And then hed always make me happy. Id never, like, really get upset around him, unless I was hurt.

Unless you were hurt, you said.

Yeah, because we did all sorts of crazy things.

Wait, now, I need to understand some of the crazy things you did with him.

Um, well, hed take me out on the roof. Once we brought sleeping bags on the roof.

The roof of your house?

No, my grandpas house, but we didnt tell my dad about it until afterwards.

Wow. It sounds like he has a slightly mischievous quality to him.

Yeah.

Can you tell me about that? What was that like?

Well, it would usually be like the middle of summer. And we would grab the stepladder, and open the window, pull up the screen, climb up onto the edge of the roof up to our special spot.

Just laid there on the roof. And we just looked at the stars and talked for a while.

What kinds of things would your grandfather say?

Um, Here, Tilly, lets look for the Big Dipper, maybe the Milky Way if were lucky, and Mars. I might be like, Wait, but isnt Mars a planet, not a star? He would just be like, But we can see it as a red star kind of.

Mm-hm.

The stars were really bright and it was really warm outside, and it was beautiful.

How often would you see your grandfather?

We wouldnt see him, like, every single weekend, but, like, wed see him a lot. Hed, like, come to my school and hed sit in the lunchroom with me.

Wow. He would just show up? Did he announce himself? Was it unexpected?

He would never tell me that he was coming. And hed just be waiting for me right next to the lunchroom door, just waiting for me. And then Id just look around for him every time.

Mm-hm.

Hed sit right next to me. And Id have my lunchbox and hed kind of just pick out things from it. Sometimes, hed take my chips, and Id be like, Papa! Hed talk to my friends. Hed talk about, like, all these fun things, like all his stories about, like, going to Tanzania and all sorts of things.

And what would you think when you saw him?

Um, I think Id be proud. Id be proud that my grandpa comes to my school a lot to just eat lunch with me and tell my friends all these stories.

Mm-hm.

He was just there right when I needed it, which made me feel really nice.

Yeah, I dont know a lot of grandpas or grandmas whod do that. Thats really special.

Yeah.

So I want you to tell me, if youre willing, the story of the last few weeks and what happened with your grandfather.

Yeah.

And I wonder I dont know where you think we should start.

Uh, I think we should, like, start from the beginning.

Um, so papa and my grandma went to the holy lands. He wanted to take his church group there.

So they went to the Middle East?

Yeah, where baby Jesus was born and like thats sort of the place. And then they got this warning there, an outbreak has started here of the coronavirus. And so when they came back, they were straight into quarantine. But right when they came back, papa started getting really ill. He had high fever, a really high fever. And in my mind, the first week he was home, I was like, Oh, hes fine. Hell get through this. Hes strong. But then he got worse and worse. And I was like, Oh, no, its going to happen. I was just kind of in a worried state, but like not like a oh, my gosh, Im really, really sad, that sort of thing, until a couple weeks later. He just couldnt do it and he got lifted to the hospital here.

And Tilly, were you talking to him during this time?

No, I didnt get to talk to him at all. I mean, we sent him, like, letters, but I dont know if he even got to read those.

I remember so when I heard about that he was put in the hospital cause it got worse, mom was like, do you want to sleep with one of his shirts? I was like, yeah. So she brought me this shirt. It was just like a greenish-brown T-shirt.

Were you wearing it or was it just beside you?

I was wearing it. It felt really, really big on me. Um, it was kind of like cold, but it felt really soothing to wear it though.

I wanted to feel like I was close to him, I was giving him a hug. And I thought about him the whole night. I prayed that he would make it through, that he wouldnt have to go.

But my prayer really didnt come true because he had a stroke during the night from a heart disease that he had.

Mm.

And that made it super worse. Even if we did get him back, he wouldnt actually, like, his body would be there, but he wouldnt be there. He couldnt do anything, like he couldnt talk he couldnt do the things that made him him.

Mm-hm. And how did you learn the news?

Mom got a call, and then I looked at her and I saw worry. So I kind of just did stuff. And then mommy told me what happened.

And what did she tell you?

She told me about the living will that my grandma, my dad, and my uncles read it well, the doctor read it to them that it said that if something happened, he wanted to go. He didnt want to, like, have to suffer in this state.

So your grandfather had written a will that made clear that if he got very sick and hed reached a condition where things werent working out, that he wanted to be allowed to die?

Yeah. And he just wanted to go to heaven and be with God. Like he says, he wanted to fall in the arms of God.

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U.S. Reports More Than 70,000 New Coronavirus Cases for the Second Time - The New York Times

The Coronavirus Exposed the Wests Weakest Link – The Atlantic

Europe already stands accused of letting Italy down at its moment of greatest needwhen hospitals were overwhelmed and Rome asked for supplies and aid, European nations initially looked the other way, before eventually offering support. That may have already been too late, coloring Italians views of their neighbors. With the bailout package, the EU was again divided. The Netherlands, Austria, Denmark, Sweden, and Finland had been wary of endorsing the plan out of a historic reluctance to send money to what they see as the profligate countries of the South. (Never mind that Italy didnt bring the virus upon itself, and that the countries in the euro zone are deeply interconnected.)

Within Italy, too, there is intense political debate about the funds. The countrys coalition government is supportive of the plan, but the right-wing opposition League party has been critical, saying the support would come with too many strings attached.

Yet beyond the political squabbles, whether in Rome or other European capitals, lies a greater challenge: To make effective use of the EU funds, Italy needs political vision, something it has singularly lacked for decades. Following the introduction of the euro in 2002, Silvio Berlusconi dominated the political landscape. The former prime ministers cult of personality and sex scandals took center stage, rivals were united only in opposition to him, and Italy lost years to mismanagement of its economy. Berlusconi left power at the height of the European debt crisis, in 2011, but the countrys economy never fully recovered.

Read: Berlusconi was Trump before Trump

The EU plan recommends that countries spend the funding on long-term investments like green technology and digital infrastructure, areas in which Italy lags. This poses difficult questions. When does the present become the future? When youve rallied to put out a fire like the coronavirus, how do you begin to rebuild? If the future isnt the same as the past, how can we live if we only exist in the present, without planning, hope, or imagination? the columnist Ezio Mauro recently wrote in La Repubblica, a center-left daily. A shrinking middle class and networks of local interest groups, Mauro continued, can easily trap weak political leadership into placating them, rather than articulating a plan to transform the country.

Italys largest political parties are more and more disconnected from the European mainstream, with none presenting a far-reaching vision of what a modern Italy could look like. The governing Five Star Movement, a contradictory collection of environmentalism and right- and left-wing policies, is the largest party in Parliament, but it trails in the polls. Its coalition partner, the center-left Democratic Party, has been treading water for years and, unlike other aging movements, such as those in France, lacks a Macron-like figure who can reinvent it. Neither is as popular as the League, led by Matteo Salvini, who has ridden a nationalist, anti-immigrant message and savvy use of social media to the top of the polls.

I used to say that Italy was a great laboratory for political ideas, the Silicon Valley of populism, and that there were lessons to learn from Italy that could spread, Giuliano da Empoli, an erstwhile adviser to former Italian Prime Minister Matteo Renzi, told me. Now its no longer a laboratory; its a loose cannon.

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The Coronavirus Exposed the Wests Weakest Link - The Atlantic

That fake story connecting dead bodies and Black Lives Matter is back – PolitiFact

The logo at the top of a website called Now 8 News looks like it could be the logo of a local television station. The slogan below it reads: "First in news." But the supposed news story that social media users are now sharing from the site is fake.

"Los Angeles police: 12 white female bodies in garage freezer tagged, Black Lives Matter," it says. Though the story is undated, it claimed the Los Angeles Police Department made the "gruesome discovery today."

"Upon arriving at the scene, police knocked on the door to be greeted by a man under the influence of drugs," the story says, italicizing that detail. "Upon further investigation, they found 12 White Female Bodies in Garage Freezer Tagged, Black Lives Matter."

The victims were all white women in their mid-20s with blond hair, according to the story, and a suspect is identified only as "Mathis."

This post was flagged as part of Facebooks efforts to combat false news and misinformation on its News Feed. (Read more about our partnership with Facebook.)

The images that appear with the story one of a Black man looking at the camera and the other showing the back of a man in a shirt that says "coroner" are the same images from a similar hoax we fact-checked in 2017. Only in that version of the story, a 39-year-old man in Chicago was arrested after police found "19 white female bodies in freezers with Black Lives Matter carved into skin."

But we called LAPD to be sure. "Fake news," a spokesperson said.

We rate this story Pants on Fire.

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That fake story connecting dead bodies and Black Lives Matter is back - PolitiFact

Here is why Liberty Latin America Ltd. (LILAK) stock volatility recorded over the last month was 4.97% – The InvestChronicle

For the readers interested in the stock health of Liberty Latin America Ltd. (LILAK). It is currently valued at $9.50. When the transactions were called off in the previous session, Stock hit the highs of $9.67, after setting-off with the price of $9.61. Companys stock value dipped to $9.395 during the trading on the day. When the trading was stopped its value was $9.68.

Recently in News on July 2, 2020, VTR Completes Issuance of $1.15 Bn New Notes. Average Maturity Extended to 7 Years Weighted Average Interest Rate for New Notes of 5.7%. You can read further details here

Liberty Latin America Ltd. had a pretty Dodgy run when it comes to the market performance. The 1-year high price for the companys stock is recorded $19.84 on 01/03/20, with the lowest value was $8.02 for the same time period, recorded on 05/14/20.

Price records that include history of low and high prices in the period of 52 weeks can tell a lot about the stocks existing status and the future performance. Presently, Liberty Latin America Ltd. shares are logging -52.38% during the 52-week period from high price, and 18.45% higher than the lowest price point for the same timeframe. The stocks price range for the 52-week period managed to maintain the performance between $8.02 and $19.95.

The companys shares, operating in the sector of Communication Services managed to top a trading volume set approximately around 1640583 for the day, which was evidently higher, when compared to the average daily volumes of the shares.

When it comes to the year-to-date metrics, the Liberty Latin America Ltd. (LILAK) recorded performance in the market was -51.18%, having the revenues showcasing -9.52% on a quarterly basis in comparison with the same period year before. At the time of this writing, the total market value of the company is set at 1.25B, as it employees total of 10000 workers.

According to the data provided on Barchart.com, the moving average of the company in the 100-day period was set at 10.37, with a change in the price was noted -7.67. In a similar fashion, Liberty Latin America Ltd. posted a movement of -44.67% for the period of last 100 days, recording 1,203,529 in trading volumes.

Raw Stochastic average of Liberty Latin America Ltd. in the period of last 50 days is set at 39.00%. The result represents downgrade in oppose to Raw Stochastic average for the period of the last 20 days, recording 44.12%. In the last 20 days, the companys Stochastic %K was 45.83% and its Stochastic %D was recorded 40.66%.

Considering, the past performance of Liberty Latin America Ltd., multiple moving trends are noted. Year-to-date Price performance of the companys stock appears to be encouraging, given the fact the metric is recording -51.18%. Additionally, trading for the stock in the period of the last six months notably deteriorated by -49.79%, alongside a downfall of -42.81% for the period of the last 12 months. The shares 0.74% in the 7-day charts and went up by -5.19% in the period of the last 30 days. Common stock shares were lifted by -9.52% during last recorded quarter.

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Here is why Liberty Latin America Ltd. (LILAK) stock volatility recorded over the last month was 4.97% - The InvestChronicle

Emirates Mars Mission to begin journey to the red planet – CU Boulder Today

The assembled Mars Hope probe sits in a clean room. (Credit: MBRSC/Ken Hutchison)

This month, researchers from Boulder and beyond will watch live as a slice of space exploration history launches from a pad on the Japanese island of Tanegashima.

TheEmirates Mars Mission (EMM) is slated to blast off aboard an H-IIA rocket. As soon as the weather in Japan behaves, whichit hasnt done recently, the event will mark the first step in the mission's 7-month-long journey to the red planetthe first voyage to another planet undertaken by the Arab world. The mission is led by the Mohammed Bin Rashid Space Centre (MBRSC) in the United Arab Emirates.

How to watch the launch

The EMM launch has been delayed due to weather. Once a new launch time is confirmed, viewers can watch it live online.

Launch the Livestream

The EMM team is waiting for a clear weather window, said Omran Sharaf, project director for the mission, which we expect daily now.

The launch of the spacecraft, called the "Mars Hope probe," will also be a big moment for the Laboratory for Atmospheric and Space Physics (LASP) at the University of Colorado Boulder. Since 2014, researchers at the institute have worked side-by-side with dozens of young scientists and engineers from the UAE to help them make this mission a reality.

Hope will capture the ebbs and flows of weather on Mars to a degree that wasnt possible before," said Daniel Baker, director of LASP. "Its a showcase for how space exploration has become an increasingly international endeavor."

Read the announcement from LASP

CU Boulder Chancellor Philip DiStefano applauded the efforts of the Colorado scientists and students who worked on the mission and their colleagues overseas.

This new Mars mission shows Colorados growing leadership in the aerospace industry, both here at home and around the world, DiStefano said. That our scientists and engineers can share their knowledge with the next generation of space pioneers across borders is inspiring.

For LASP, the Emirates Mars Mission is the latest step in more than 70 years spent exploring the solar system. For example, LASP is the lead research institute for the Mars Atmosphere and Volatile Evolution (MAVEN) mission, which arrived at Mars in 2014. Among other pursuits, the mission investigates how gases escape from the Martian atmosphere into space, leaving the planet with unusually thin air.

Hope science will be complementary to the science data gathered by MAVEN and a number of other orbital missions that have taken atmospheric measurements on the planet. The probe will enter into a unique orbit around Mars, allowing it to observe weather patterns at every point around the red planet and from the top to the bottom of its atmospheresomething that no mission from any country has ever done to date.

If theres a dust storm on Mars, changes in temperature, how do those impact rates of atmospheric escape? said Sarah Al Amiri, EMMs science lead, in last weeks press conference.

Designing a spacecraft to do all of that was no easy feat, said Pete Withnell, program manager for EMM at LASP.

To finish the project in just six years, the UAE partnered with LASP to assemble and test the spacecraft in facilities on the CU Boulder campus. The UAEs goal for the project was to build it not buy it, according to Sharaf.

Teams worked on both sides of the globe, both separately, and in extended trips and stays. The hands-on experience of building hardware happened primarily in Boulder, but team members experienced cultural exchanges and outdoor adventures in both locations.

The effort was a lesson in how people from different cultures can work together to complete a space mission on time and under budget. Knowledge transfer on the mission came in the form of hands-on learning through an integrated team approach with shared responsibilities.

There are multiple stories of Emirates engineers who started on the program with perhaps little experience in aerospace and ended up defending complex spacecraft subsystems and designs in front of seasoned review panels, Withnell said.

Withnell added that the team is confident that EMM will get the job done, but that wont make the next few weeks any less nerve-wracking. About an hour after the Hope Probe leaves its launch pad, the spacecraft will separate from its rocket and extend its solar panels. From there, it will begin making moves that will take it to Marsnot an easy target to hit from Earth.

Its equivalent to an archer hitting a 2-mm target 1 kilometer away, Withnell said. This is not for the faint of heart.

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Emirates Mars Mission to begin journey to the red planet - CU Boulder Today