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Honeywell and SLM Solutions qualify parameters for 3D printing thicker aluminum aerospace parts – 3D Printing Industry

Posted on July 26, 2020 by Danzig

German metal 3D printer manufacturer SLM Solutions has worked with the aerospace division of multinational manufacturing conglomerate Honeywell, to produce a parameter set for 3D printing aluminum F357.

Developed as part of the companies ongoing partnership, the material reportedly provides 3D printed parts with considerably improved properties compared to those created through die-casting methods. In addition, the advanced additive metal could also address both partners wider goals of reducing manufacturing times and costs, and 3D printing aircraft components that meet industry standards.

The open architecture system of the SLM machine provides huge advantages like high flexibility, and parameter sets can be customized, said Dr. Sren Wiener, Senior Director of Technology and Advanced Operations at Honeywell Aerospace. With this open access strategy and the great support of SLM Solutions, we step forward to achieving our next goals.

SLM and Honeywells 3D printing partnership

Based in Luebeck, Germany, SLM Solutions is a specialist in developing and providing Selective Laser Melting (SLM) 3D printers. TheSLM 800metal additive systemwas revealed at Formnext 2017, and features a quad-laser configuration with four 400 W or 700 W lasers, and a large build envelope measuring 500 x 280 x 850 mm.

The companys additive manufacturing technology has been utilized within a range of applications, including in the production of the worlds largest 3D printed rocket engine for British aerospace firm Orbex. This was followed by collaborations with Italian service bureau BEAMIT, which saw the companies develop new printing settings for SLM printers, and cycling supplier CeramicSpeed, where it 3D printed pulley wheels for professional cyclists.

Nonetheless, neither of the companys existing partnerships yielded impressive financial results for SLM Solutions, and it announced a 38.3 percent decline in sales last year. Since then, SLM has begun working with Honeywell to qualify new additive manufacturing parameters, to enable 3D printing at increased thicknesses, and its fortunes have changed. Now, not only has the company revealed record financial results for the first quarter and will likely be hoping that its collaboration with Honeywell, could lead to new applications of its metal 3D printing technology.

The aerospace applications of aluminum F357

In the early stages of their collaborative work in December last year, Honeywell began attempting to qualify aluminum builds using its quad-laser SLM 500 3D printer. Working with the aluminum alloy F357, a new beryllium free version of AlSi7Mg0,6 (A357), the company experimented with increasing the layer thicknesses of parts to 60 and 90 m respectively.

SLM Solutions initially provided generic aluminum parameter sets for Honeywell to completematerial qualification and achieve optimal material properties, but now development has reached an important milestone. Using a new set of printing settings, the companies have 3D printed components that display significantly increased mechanical properties in comparison to those exhibited by conventional diecast parts.

Moreover, such robust, high-strength parts are now able to meet the required standard for enabling widespread aerospace adoption. As a result, F357 aluminum is highly sought after within the industry and it provides desirable mechanical properties too, such as enhanced corrosion resistance, and high-strength across a wide temperature range. The alloy also reportedly offers great weldability, and excellent suitability for post-processing, like mechanical machining or within electrochemical processes such as anodizing.

These characteristics lend themselves to creating thin, complex structures for applications in both the aerospace and automotive industries. As a result, the newly-developed printing parameters represent a landmark achievement in the companies ongoing partnership.

It is a privilege to work together with one of the leading companies in the aerospace world, concluded Benjamin Haas, Product Manager for Materials & Parameters at SLM Solutions. This way, we can learn a lot from each other leading to perfectly suited, industry proven solutions from which all of our customers can benefit.

Aluminum materials in the 3D printing industry

Aluminum alloys are commonly used for manufacturing automotive and aerospace components, but they have been used to produce a range of end-use parts, ranging from sports equipment to dashboard panels. More recently, 3D printing companies have sought to develop metals with enhanced mechanical performance, in order to expand on these applications and create parts with improved qualities.

Metal additive manufacturing specialist Amaerohas entered the final phase of gaining international patent approval for its Amaero HOT Al aluminum alloy. The newly-developed metal has high scandium content and can be heat treated and age hardened after 3D printing, giving it a boost to strength and durability.

Materials manufacturer QuesTek Innovations LLC meanwhile, is developing a new 3D printer feedstock in collaboration with the German Aerospace Center (DLR). An aluminum alloy, the new material from the two companies, will exhibit high strength at elevated temperatures between 200 and 300C.

California-based HRL Laboratorieshas developed a powder format aluminum 3D printing material, which it claims is the strongest additive manufacturing aluminum to date. The alloy has already been utilized within a variety of industries, including on the Marshall Space Flight Center, which has begun using the material to produce large-scale aerospace components.

You can now nominate for the 2020 3D Printing Industry Awards. Cast your vote to help decide this years winners.

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Looking for a job in the additive manufacturing industry? Visit 3D Printing Jobs for a selection of roles in the industry.

Featured image shows SLM Solutions SLM 3D printing technology in action. Image via SLM Solutions.

Honeywell and SLM Solutions qualify parameters for 3D printing thicker aluminum aerospace parts - 3D Printing Industry

Md. on the Hook for $27K in Legal Fees to Conservative Group – Josh Kurtz

Posted on July 26, 2020 by Danzig

The State of Maryland is on the hook for $27,000 in legal fees to a national conservative organization that sued the state three years ago over voter registration rolls.

Its part of a settlement the state reached with the group Judicial Watch after a federal court earlier this year ordered the state to make all voter registration data available to the conservative organization.

Judicial Watch sued Maryland to obtain voter list data in 2017 after alleging that there were more registered voters in Montgomery County than citizens over the age of 18 who were eligible to register. It was part of the conservative groups nationwide campaign to clean up voter rolls.

In August 2019, U.S. District Court Judge Ellen L. Hollander ordered the State Board of Elections to produce the Montgomery County voter data, concluding that Maryland election law is an obstacle to the intent of the National Voter Registration Act of 1993.

Following the court ruling, state elections officials initially provided Judicial Watch with a list of registered voters but one that did not include their dates of birth. On April 17, the court ordered the state to produce the registration list with every voters date of birth.

Maryland politicians fought us tooth and nail to keep Judicial Watch from uncovering the full truth about their dirty election rolls, Judicial Watch President Tom Fitton said in April following the federal court ruling. This latest court victory will allow Judicial Watch to ensure Maryland and Montgomery County are removing voters who have moved or died long ago.

The Maryland Board of Public Works is set to vote Wednesday to confirm the $27,000 settlement payment to Judicial Watch.

At the same meeting, the BPW is scheduled to vote on a proposed $35,600 payment to reimburse attorneys for the Maryland Green Party and the Libertarian Party of Maryland for ballot access litigation against the state.

The third parties sued the state in May to reduce the signature requirement to appear on the November ballot. They argued that the states stay-at-home order and social distancing guidelines since the outbreak of COVID-19 made it impossible for them to exercise their First Amendment rights.

The Greens and Libertarians reached a settlement with the state a month ago cutting in half the petition signature requirement for gaining ballot access for the November general election.

As part of the settlement, the Green Party and its law firm are in line for a $25,000 payment from the state, while the Libertarians and the Center for Competitive Democracy, a national ballot access organizational, will split $10,600.

In a related development, Amber Ivey, an unaffiliated candidate for Congress in the 7th District, announced Monday that she had reached an agreement with state elections officials that would cut her signature requirement for ballot access in half. Initially, the State Board of Elections had said the state ballot access settlement with the Green and Libertarian parties would not apply to independent candidates, but Ivey sued.

I believe that every person has the right to ballot access, she said in a statement. COVID-19 restrictions have made it especially hard for candidates to collect signatures, which interferes with their constitutional right to seek to be on the ballot.

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Md. on the Hook for $27K in Legal Fees to Conservative Group - Josh Kurtz

Litecoin, Stellars Lumen, and Trons TRX Daily Analysis July 23rd, 2020 – Yahoo Finance

Posted on July 26, 2020 by Danzig

Litecoin

Litecoin rose by 2.83% on Wednesday. Following a 4.53% rally on Tuesday, Litecoin ended the day at $45.02.

It was a mixed start to the day. Litecoin rose to an early morning high $44.00 before hitting reverse.

Falling short of the first major resistance level at $44.66, Litecoin fell to a late morning intraday low $43.22.

Steering clear of the first major support level at $42.45, Litecoin recovered to a late intraday high $45.17.

Litecoin fell broke through the first major resistance level at $44.66 to wrap up the day at $45 levels.

At the time of writing, Litecoin was up by 1.00% to $45.47. A bullish start to the day saw Litecoin rise from an early morning low $44.96 to a high $45.75.

Litecoin came up against the first major resistance level at $45.72 earl in the day.

Litecoin would need to avoid a fall through the $44.50 pivot to support another run at the first major resistance level at $45.72.

Support from the broader market would be needed, however, for Litecoin to break back through to $45.70 levels.

Barring another crypto rally, the first major resistance level and the morning high $45.75 would likely cap any upside.

Failure to avoid a fall through the $44.50 pivot would bring the first major support level at $43.77 into play.

Barring an extended crypto sell-off, however, Litecoin should steer clear of sub-$43 levels. The second major support level sits at $42.52.

First Major Support Level: $43.77

First Major Resistance Level: $45.72

23.6% FIB Retracement Level: $62

38.2% FIB Retracement Level: $78

62% FIB Retracement Level: $104

Stellars Lumen gained 1.10% on Wednesday. Following on from a 2.59% rally on Tuesday, Stellars Lumen ended the day at $0.097241.

It was a mixed start to the day. Stellars Lumen rose to an early morning high $0.096339 before hitting reverse.

Falling short of the first major resistance level at $0.09887, Stellars Lumen slid to a late morning intraday low $0.094291.

Finding support the first major support level at $0.09439, Stellars Lumen rallied to a late intraday high $0.098196.

Coming up short of the first major resistance level at $0.09887, Stellars Lumen eased back to sub-$0.09750 levels.

At the time of writing, Stellars Lumen was up by 2.12% to $0.099306. A bullish start to the day saw Stellars Lumen rise from an early morning low $0.09737 to a high $0.099396.

Stellars Lumen broke through the first major resistance level at $0.09886.

Story continues

Stellars Lumen would need to avoid a fall through the first major resistance level to support a run at the second major resistance level at $0.10048.

Support from the broader market would be needed, however, for Stellars Lumen to break out from the morning high $0.099306.

Barring another broad-based crypto rally, the second major resistance level would likely limit any upside.

Failure to avoid a fall through the first major resistance level at $0.9886 would bring sub-$0.097 levels into play.

Barring an extended crypto sell-off, however, Stellars Lumen should avoid the pivot level at $0.09658. The first major support level sits at $0.09496.

First Major Support Level: $0.09496

First Major Resistance Level: $0.09886

23.6% FIB Retracement Level: $0.1051

38% FIB Retracement Level: $0.14336518

62% FIB Retracement Level: $0.2050

Trons TRX rose by 2.25% on Wednesday. Following a 2.42% rally on Tuesday, Trons TRX ended the day at $0.017984.

It was a mixed start to the day. Trons TRX rose to an early morning high $0.017630 before hitting reverse.

Falling short of the first major resistance level at $0.01786, Trons TRX fell to a mid-morning intraday low $0.017425.

Steering clear of the first major support level at $0.01732, Trons TRX rallied to a late intraday high $0.018001 before easing back.

Trons TRX broke through the first major resistance level at $0.01786 before easing back to sub-$0.018 levels.

The second major resistance level at $0.01807 capped the upside on the day.

At the time of writing, Trons TRX was up by 0.42% to $0.018059. A bullish start to the day saw Trons TRX rise from an early morning low $0.017968 to a high $0.018100.

Trons TRX left the major support and resistance levels untested early on.

Trons TRX would need to avoid a fall through the $0.01780 pivot level to support another run at the first major resistance level at $0.018180.

Support from the broader market would be needed, however, for Trons TRX to break out from the morning high $0.01810.

Barring an extended crypto rally, the first major resistance level and morning high would likely cap any upside.

Failure to avoid a fall through the $0.01780 pivot level would bring the first major support level at $0.01761 into play.

Barring another extended crypto sell-off, Trons TRX should steer clear of sub-$0.01720 levels. The second major support level at $0.01723 should limit any downside.

First Major Support Level: $0.01761

First Major Resistance Level: $0.01818

23.6% FIB Retracement Level: $0.0322

38.2% FIB Retracement Level: $0.0452

62% FIB Retracement Level: $0.0663

Please let us know what you think in the comments below

Thanks, Bob

This article was originally posted on FX Empire

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Litecoin, Stellars Lumen, and Trons TRX Daily Analysis July 23rd, 2020 - Yahoo Finance

The Vital Role Genetic Testing Plays in Bladder Cancer Treatments – Cancer Therapy Advisor

Posted on July 26, 2020 by Danzig

Sponsored Content by the Janssen Pharmaceutical Companies of Johnson & Johnson

Recent research suggests cancer patients who have undergone genetic testing for inherited or acquired mutations were more likely to have prolonged overall survival than patients who did not, as genetic tests can direct healthcare providers to targeted treatment paradigms featuring therapies specific to an individuals genetic makeup.1,2

Various genetic alterations impact how specific tumors can arise or develop, including BRCA1/2, p53, HER2 and the RAS family of genes, among others.3 As researchers continue to study how genetic changes impact cancer development, findings have led to improvements in cancer care including the increased use of targeted therapies and early detection strategies.3

Treating with an inhibitor or a targeted therapy may slow or halt uncontrolled cell growth that may be driven, in part, by a genetically-altered cancer and can provide clinical benefits to patients, said Tracy McGowan, MD, Strategic Area Lead for Medical Affairs at Janssen Biotech, Inc. Analyzing a patients DNA or RNA for actionable genetic alterations can help direct a cancer patients treatment plan, and is intended to provide patients and providers with treatment options that are specific to the unique characteristics of an individuals specific tumor type.

An example of the above is the fibroblast growth factor receptor (FGFR) genetic alteration, which occurs in approximately one in five patients with metastatic urothelial carcinoma (mUC).4,5 FGFR genes, a family of receptor tyrosine kinases, impact tumor cell proliferation, migration and survival in both non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC) including mUC.6 This is also true in a variety of other tumor types as well.4

Dr. McGowan is hopeful that, over time, more healthcare providers will recommend genetic testing earlier in the course of bladder cancer to ensure that appropriate treatment options are available for consideration. In the evolving era of precision medicine, it is important to inform patients and their families about the role of genetic testing to help them navigate treatment opportunities. For healthcare providers, talking to patients about the role of genetic testing in their care plan is the beginning of important conversations especially when specific targeted therapies are now available.

References

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The Vital Role Genetic Testing Plays in Bladder Cancer Treatments - Cancer Therapy Advisor

CRADLE GENOMICS: Expands Executive Team, Accelerating Efforts to Transform Non-Invasive Prenatal Testing and Patient Care – Patient Daily

Posted on July 26, 2020 by Danzig

Cradle Genomics issued the following announcement on July 24.

Cradle Genomics today announced the expansion of its executive team with the additions ofTanya Moreno, PhD, as Vice President of Development andSue Gross, MD, as Chief Medical Officer.

"Our mission at Cradle is to deliver genetic knowledge for life, with a vision of better outcomes for every pregnancy," saidTristan Orpin, CEO of Cradle Genomics. "The outstanding additions of Dr. Moreno to lead clinical development and Dr. Gross as CMO will enable Cradle to achieve our vision of transforming prenatal testing and patient care."

Dr. Moreno has over 13 years of experience in diagnostics development and the commercialization of genomic tests. As the head of clinical sciences, in multiple clinical laboratories, she has led development programs across a broad range of advanced genomic tools to empower patients and physicians with precision medicine. Dr. Moreno earned her Ph.D. in molecular genetics and developmental biology at the California Institute of Technology and received her postdoctoral training at the Salk Institute for Biological Studies. She is widely published in peer-reviewed journals and has both led and participated in a number of research studies in consumer and clinical genomics. She is an inventor of several novel genomic applications with multiple patents pending and issued.

Dr. Gross has had a distinguished clinical career with roles at Montefiore Einstein where she was Professor of Obstetrics and Gynecology, Pediatrics and Genetics; Natera where she was Chief Medical Officer; and most recently at Mount Sinai Hospital and Sema4 where she was the Medical Director for the Reproductive Lab and Clinical Analysis Division. She is double board certified in Obstetrics and Gynecology as well as Medical Genetics.Dr. Gross has served on national and international guideline committees and has lectured and published extensively on prenatal screening and genetic testing, with a focus on new technologies and public health policy.

About Cradle GenomicsCradle Genomics is headquartered inSan Diego, California.Cradle is developing novel fetal genetic analysis and pregnancy health solutions at the earliest stages of pregnancy.For more information, visit http://www.cradlegenomics.com

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CRADLE GENOMICS: Expands Executive Team, Accelerating Efforts to Transform Non-Invasive Prenatal Testing and Patient Care - Patient Daily

Elevation Oncology Emerges from Stealth with $32.5M Series A to Develop Precision Medicines for Tumors Harboring Rare Genetic Driver Alterations -…

Posted on July 26, 2020 by Danzig

NEW YORK, July 21, 2020 /PRNewswire/ --Elevation Oncology, a clinical stage biopharmaceutical company focused on the development of precision medicines for patients with genomically defined cancers, announced today the launch of the Company with a $32.5M Series A financing, initiation of the Phase 2 CRESTONE study, and new partnerships with Next Generation Sequencing diagnostic providers including Ashion Analytics, Strata Oncology, and Tempus to explore innovative models for real-time identification, patient referral, and enrollment of patients with tumors driven by rare genomic alterations. The Series A financing was led by Aisling Capital and a syndicate of investors including Vertex Ventures HC, Qiming Venture Partners USA, Driehaus Capital Management, and BVF Partners.

"At Elevation Oncology, we envision a future in which each unique genomic testing result can be matched with a purpose-built precision medicine and bring clarity to the patient treatment journey. Focused drug development paired with open collaboration will be instrumental for our industry to fully realize the potential of precision medicine for all patients with cancer," said Shawn Leland, PharmD, RPh, Founder and Chief Business Officer of Elevation Oncology. "With our lead development program, seribantumab, and the partnerships announced today, we are taking our first steps toward this future."

Seribantumab and the Tumor-agnostic CRESTONE Study

Seribantumab is a fully human IgG2 monoclonal antibody that binds to human epidermal growth factor receptor 3 (ERBB3 or HER3). HER3 is traditionally activated through binding of its primary ligand, neuregulin-1 (NRG1). The NRG1 gene fusion is a rare genomic alteration that combines NRG1 with another partner gene to create chimeric NRG1 "fusion proteins."

Seribantumab was acquired in 2019 by Elevation Oncology, and the development program builds on prior clinical experience from over 800 patients demonstrating consistent safety and tolerability. Previous clinical trials with seribantumab did not select for tumors with an NRG1 fusion. The CRESTONE study leverages seribantumab's rational design with recent discoveries on the significance of the NRG1 gene fusion and improvements in diagnostic sensitivity. Novel preclinical data generated by Elevation Oncology demonstrating the ability of seribantumab to prevent the activation of HER3 signaling in NRG1 fusion models are supportive of CRESTONE and are expected to be released in publications and at scientific conferences later this year.

Although rare, NRG1 gene fusions are oncogenic drivers that can be found in a variety of solid tumors, including lung, pancreatic, gallbladder, breast, ovarian, colorectal, and neuroendocrine cancers, and sarcomas. Importantly, NRG1 gene fusions are mutually exclusive with other known driver mutations and are considered a unique oncogenic driver event essential for tumor cell survival. Following recent regulatory approvals of tumor-agnostic treatments associated with oncogenic drivers, CRESTONE is designed as a registration-enabling Phase 2 "basket trial" to evaluate the efficacy and safety of seribantumab in patients with any solid tumor that harbor an NRG1 fusion.

"Genomic testing and matched precision therapeutics are creating a revolution in oncology development and regulatory approval paths," said Lori Kunkel, MD, Chair of the Elevation Oncology Scientific Advisory Board and former Chief Medical Officer LOXO Oncology. "The FDA has recently approved several oncology therapeutics for tumor-agnostic indications. I am encouraged to see the evolution in our understanding of how to achieve better clinical outcomes to address the unmet clinical need among patients with a genomically defined cancer, regardless of its tissue of origin. The CRESTONE study potentially expands the actionability of genomic tests to tumors with an NRG1 fusion and is a promising approach for furthering this genomically-driven tumor-agnostic development pathway."

Innovative Models for Patient Enrollment

Sarah Cannon Research Institute(Sarah Cannon) has been selected as the first strategic site for CRESTONE and is open and enrolling patients today. Sarah Cannon's world class clinical research leadership and insights as well as additional prospectively selected clinical sites are foundational to ensuring rigorous study conduct.

"Identifying potential driver alterations, such as NRG1 gene fusions, enables us to approach cancer treatment in a more targeted way," said David Spigel, MD, Chief Scientific Officer, Sarah Cannon Research Institute at Tennessee Oncology and one of the investigators of the CRESTONE study. "Today, all cancer patients facing a treatment decision without clear standard of care should consider comprehensive genomic testing for their tumor. Collaborations across the healthcare ecosystem help to ensure that the value of each genomic test is maximized and to expand access to critical treatment opportunities for patients."

Diagnostic partnerships will enhance traditional patient enrollment in the CRESTONE study through real-time, nationwide identification of NRG1 fusion positive patients withintheAshion, Strata Oncology, Tempus, and other partner networks. Through various partnership models, patients may also be enrolled in CRESTONE through active referral to current strategic sites or "just-in-time" site initiation.

These innovative models address specific challenges encountered by genomically-driven, tumor-agnostic trials such as the rarity of genomic driver alterations and the impracticality of comprehensive clinical site coverage by both geography and organ-system of study. In addition, these models may reduce the burden on patients by minimizing the number of diagnostic tests they may need and maximizing the treatment opportunities available to them, regardless of where they may live. Bringing clinical trials to patients using the "just-in-time" site initiation model can further help to minimize travel and keep patients safe in the face of ongoing travel restrictions due to COVID-19.

"With the strong backing of a dynamic and experienced investor syndicate, Elevation Oncology is well positioned to execute on our mission of delivering precision medicines to physicians and their patients with cancer," said Steve Elms, Chairman and Interim Chief Executive Officer of Elevation Oncology and Managing Partner of Aisling Capital. "Our development approach to seribantumab sets the stage for our broader vision: the elevation of precision medicine to the forefront of every patient journey through building a collaborative industry-wide ecosystem. Together with diagnostic developers, clinical researchers, patient advocates, and the Elevation Oncology team, we are looking to build a pipeline of precision oncology medicines that can amplify each other's efforts towards our shared goal of improving patient outcomes."

About Elevation Oncology

Elevation Oncology is founded on the belief that every patient with cancer deserves to know what is driving the growth of their disease and have access to therapeutics that can stop it. We make genomic tests actionable by selectively developing drugs to inhibit the specific alterations that have been identified as drivers of disease. Together with our peers we work towards a future in which each unique test result can be matched with a purpose-built precision medicine to enable an individualized treatment plan for each patient. Our lead candidate, seribantumab, inhibits tumor growth driven by NRG1 fusions and is currently being clinically tested in the Phase 2 CRESTONE study for patients with tumors of any origin that have an NRG1 fusion. Details on CRESTONE are available at http://www.NRG1fusion.com. For more information visit http://www.ElevationOncology.com.

About Ashion Analytics

Ashion Analytics, LLC, is a CLIA-certified and CAP-accredited clinical laboratory that uses advanced genomic technologies to offer a wide range of testing capabilities to assist physicians, health systems, research and commercial partners to provide precision cancer treatments. Ashion was developed and launched by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope. TGen is a pioneer in the use of genomics to identify treatment options for cancer patients.

About Strata Oncology

Strata Oncology, Inc. is a precision medicine company dedicated to transforming cancer care by building a platform to systematize precision oncology across a network of health systems and biopharma companies. Strata Oncology empowers health systems to deliver a comprehensive, system-wide precision oncology program that integrates cutting-edge tumor molecular profiling and a portfolio of biomarker-guided with routine care, so that all patients with advanced cancer have the opportunity to benefit. This large network of trial-ready health systems provides a mechanism to rapidly and predictably enroll precision therapy trials. For more information visitwww.strataoncology.com.

About Tempus

Tempus is a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare. With one of the world's largest libraries of clinical and molecular data, and an operating system to make that data accessible and useful, Tempus enables physicians to make real-time, data-driven decisions to deliver personalized patient care and in parallel facilitates discovery, development and delivery of optimal therapeutics. Additionally, the TIME TrialNetwork leverages a unique and comprehensive infrastructure to bring the right clinical trials to the right patients in under two weeks.The goal is for each patient to benefit from the treatment of others who came before by providing physicians with tools that learn as the company gathers more data. For more information, visit tempus.com.

Media Contact:Elevation OncologyDavid Rosen, Argot PartnersPhone: +1 (716) 371-1125Email: [emailprotected]

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Cradle Genomics Expands Executive Team, Accelerating Efforts to Transform Non-Invasive Prenatal Testing and Patient Care – PRNewswire

Posted on July 26, 2020 by Danzig

SAN DIEGO, July 24, 2020 /PRNewswire/ --Cradle Genomics today announced the expansion of its executive team with the additions of Tanya Moreno, PhD, as Vice President of Development and Sue Gross, MD, as Chief Medical Officer.

About Cradle Genomics Cradle Genomics is headquartered inSan Diego, California.Cradle is developing novel fetal genetic analysis and pregnancy health solutions at the earliest stages of pregnancy.For more information, visitwww.cradlegenomics.com

SOURCE Cradle Genomics

Cradle Genomics Expands Executive Team, Accelerating Efforts to Transform Non-Invasive Prenatal Testing and Patient Care - PRNewswire

How six months of pandemic have changed Illinois forever – Crain’s Chicago Business

Posted on July 26, 2020 by Danzig

Since Illinois reported its first case of the novel coronavirus on Jan. 24, COVID-19 has cut through every aspect of lifefrom the most basic social interactions to education, health care and travel.

In a span of six months, 168,000 Illinoisans have tested positive for the virus and more than 7,300 have died. Roughly 1.5 million people have applied for unemployment benefits in Illinois since March, employers' costs have skyrocketed as they implement new safety measures and governments statewide face steep budget gaps and rising calls for relief. More than 4,000 Chicago-area businesses shut down as stay-home restrictions and fear of infection kept customers out of restaurants and stores. Meanwhile, as case rates rise in other states, leaders are bracing for a new surge.

But in the midst of the gravest public health crisis in generations, people are adapting to a new way of life, full of e-learning, mask wearing and socially distant celebrations. Whether the pandemic will lead to permanent work flexibility, bigger investments in public health and unemployment, or meaningful moves toward equity is still unknown.

But how did we get here? Crain's asked Chicago-area decision-makers, business leaders and workers how the first six months of the pandemic in Illinoisfrom the controversial calls to the most pivotal momentshave affected them and what life is going to look like in the future as a result. Here's what they said. (Interviews have been edited for length and clarity.)

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How six months of pandemic have changed Illinois forever - Crain's Chicago Business

The COVID-19 Host Genome Structural Variant Consortium Formed by Dr. Ravindra Kolhe at Augusta University Creates a Massive Expansion in the Scope of…

Posted on July 26, 2020 by Danzig

SAN DIEGO, July 24, 2020 (GLOBE NEWSWIRE) -- Bionano Genomics, Inc. (Nasdaq: BNGO) announced today that a recently formed international consortium of clinical and research sites is using its Saphyr genome imaging system to identify genomic variants that influence resistance or sensitivity to the SARS-CoV2 virus, or COVID-19 disease progression and drug response. The consortium is comparing the genome structures of those patients who show no or mild symptoms and those who show severe illness, while controlling for the known risk factors of age and chronic illness such as asthma, heart disease, diabetes, or other immune-compromising disease. The team plans to analyze at least 1,000 patient genomes with Saphyr.

The consortium was founded by Dr. Ravindra Kolhe, the Vice-Chair of Pathology and Section Chief of Molecular and Genetic Pathology at Augusta University and Dr. Alka Chaubey, Scientific Director for the Georgia Esoteric & Molecular Lab at Augusta University. Additionally, it consists of co-investigators from Baylor College of Medicine, Bostons Children's Hospital of Harvard University, Childrens National Medical Center, Columbia University, George Mason University, MD Anderson Cancer Center, the National Cancer Institute, Oregon Health and Science University, Rockefeller University, San Francisco State University, Sanford Burnham Prebys, UC San Diego, UC Santa Cruz, and Virginia Commonwealth University, with many more in the process of joining.

A number of companies have committed to supporting this effort as part of a global Tech Against Covid initiative. Rescale, the High-Performance Computing cloud platform fully integrated with Saphyr, and Amazon, a leading provider of on-demand cloud computing, are donating compute time for the Bionano data analysis. Genoox, the platform for annotation and classification of genomic variants, is donating its compute resources to analyze available sequencing data combined with Bionanos structural variation calls for an integrated analysis of small and large genomic variants.

Initial unpublished findings from the first 30 patients that have been analyzed show that Saphyr detects large amounts of structural variation in many putatively relevant genes, demonstrating that point mutations alone are unlikely to explain disease differences between patients. Bionanos Saphyr system is expected to provide the crucial structural variation data needed for a full understanding of genome structure in patients.

Dr. Ravindra Kolhe, founder of the consortium commented: We strongly believe that Bionanos Saphyr platform is uniquely capable of identifying variants that play an important role in regulating COVID-19 in patients, and may be able to explain some of the extreme variation in disease severity and progression that we see in patients. Other studies of the host genome are based on short-read sequencing or SNP-microarrays, and those technologies are unable to detect and account for the large amounts of structural variation thats present in clinically important regions of the genome. We are hopeful that our initial results will translate into discoveries that truly advance our understanding of this devastating disease, and will improve our ability to treat the sickest patients.

Erik Holmlin, PhD, CEO of Bionano Genomics commented: The COVID-19 Host Genome Structural Variation Consortium is an important expansion of Bionanos efforts to help the scientific and medical community in the development of novel, targeted, antiviral therapies or vaccines. We believe that Bionanos genome imaging technology is the only technology capable of detecting the structural variants that could protect against or predispose patients to the viral infection and influence the severity of the disease. We are thrilled that our technology is being used in a global effort to help bring this pandemic to a halt.

About Bionano GenomicsBionano is a genome analysis company providing tools and services based on its Saphyr system to scientists and clinicians conducting genetic research and patient testing. Bionanos Saphyr system is a platform for ultra-sensitive and ultra-specific structural variation detection that enables researchers and clinicians to accelerate the search for new diagnostics and therapeutic targets and to streamline the study of changes in chromosomes, which is known as cytogenetics. The Saphyr system is comprised of an instrument, chip consumables, reagents and a suite of data analysis tools, and genome analysis services to provide access to data generated by the Saphyr system for researchers who prefer not to adopt the Saphyr system in their labs. For more information, visitwww.bionanogenomics.com.

Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as may, will, expect, plan, anticipate, estimate, intend and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) convey uncertainty of future events or outcomes and are intended to identify these forward-looking statements. Forward-looking statements include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: planned scope of the consortiums research; preliminary findings regarding COVID-19 through the use of Saphyr; and Saphyrs ability to contribute to research and treatment of COVID-19, including discoveries that can advance an understanding of COVID-19 and improve the ability to treat patients. Each of these forward-looking statements involves risks and uncertainties. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the risks and uncertainties associated with: the impact of the COVID-19 pandemic on our business and the global economy; general market conditions; changes in the competitive landscape and the introduction of competitive products; changes in our strategic and commercial plans; our ability to obtain sufficient financing to fund our strategic plans and commercialization efforts; the loss of key members of management and our commercial team; and the risks and uncertainties associated withour business and financial condition in general, including the risks and uncertainties described in our filings with the Securities and Exchange Commission, including, without limitation, our Annual Report on Form 10-K for the year ended December 31, 2019 and in other filings subsequently made by us with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made and are based on management's assumptions and estimates as of such date. We do not undertake any obligation to publicly update any forward-looking statements, whether as a result of the receipt of new information, the occurrence of future events or otherwise.

CONTACTSCompany Contact:Erik Holmlin, CEOBionano Genomics, Inc.+1 (858) 888-7610eholmlin@bionanogenomics.com

Investor Relations Contact:Ashley R. RobinsonLifeSci Advisors, LLC+1 (617) 430-7577arr@lifesciadvisors.com

Media Contact:Kirsten ThomasThe Ruth Group+1 (508) 280-6592kthomas@theruthgroup.com

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The COVID-19 Host Genome Structural Variant Consortium Formed by Dr. Ravindra Kolhe at Augusta University Creates a Massive Expansion in the Scope of...

UBC scientists sequencing the genomes of Canadians with COVID-19 – UBC Faculty of Medicine

Posted on July 26, 2020 by Danzig

For years, genome sequencing has helped scientists better understand the factors that predispose humans to disease. Now, the tool is being used in the fight against COVID-19.

Through the Canadian COVID Genomics Network (CanCOGeN)a new initiative launched by Genome Canada and backed by $40 million in federal fundingscientists across Canada are collaborating on genomics-based research to find solutions to COVID-19.

Dr. Terry Snutch

Among those involved are UBCs Dr. Terry Snutch and Dr. Steven Jones, both professors in the faculty of medicine. Dr. Snutch, professor in UBCs Michael Smith Laboratories and Djavad Mowafaghian Centre for Brain Health, is leading the $20 million COVID-19 genome sequencing component of the initiative, called CanCOGeN-VirusSeq. Meanwhile, Dr. Jones, who is co-director and head of bioinformatics at Canadas BC Michael Smith Genome Sciences Centre (GSC) at BC Cancer, is leading the B.C. branch of the CanCOGeN-HostSeq team to sequence the genomes of 10,000 Canadians who have tested positive for COVID-19an initiative supported by another $20 million investment from the federal government.

In this Q&A, Drs. Snutch and Jones discuss how their findings could lead to better assessment and treatment of the most vulnerable COVID-19 patients.

Dr. Steven Jones

TS: By determining SARS-CoV-2 genome sequences, we can easily identify small mutations, or variants, that arise as the virus is generating billions of copies of itself. By following the trail of these variants as they appear in patients across different regions, we can determine where that variant originated and, combined with that persons travel history, when it was introduced into the region. This is crucial to distinguishing between infections arising from travel versus community spread and provides health authorities with critical information towards recommendations regarding outbreak control and where to direct resources.

SJ: We know that COVID-19 affects people differently. Seniors and those with other diseases tend to have worse symptoms and outcomes compared with young and healthy people. But some young and otherwise relatively healthy people are also seriously affected. By assessing people who have tested positive for COVID-19, and comparing the genomes of those that have responded poorly to infection to those who responded relatively well, we can tease out differences in genes that may indicate why people respond to the virus differently.

A flow cell, the site where DNA sequencing takes place. (Photo credit: GSC)

SJ: Although we did not sequence this particular virus (laboratories in China did shortly after its initial discovery in Wuhan), UBC researchers were the first in the world to sequence a related virus, SARS-COV-1, that was responsible for the SARS epidemic in 2003. We know from that work that understanding the sequence of the virus genome can accelerate the process of finding a vaccine.

TS: The virus genome codes for about two dozen proteins. By chance, some mutations will arise spontaneously in proteins that are currently targeted for vaccine development. It is crucial that we identify and understand how viral mutations appear in vaccine-targeted proteins. If the virus mutates at a critical targeted site, a vaccine that took months or years to develop might only be partially effective by the time it is available to the public.

TS: On the genome data side, I hope that the effort will evolve into the collective Canada-wide ability to track the virus in near real time (e.g., 24-48 hours) thus becoming an invaluable tool towards COVID-19 surveillance as new outbreaks arise and the predicted second wave appears. I also hope that the viral genome data will allow us to predict and track the development of viral resistance to therapeutics treatments.

SJ: The genes associated with outcomes for COVID-19 are part of a complex puzzle. We think there is a genetic connection associated with disease trajectory and outcome, but we wont know the extent of that until we complete this study analyzing the genomes of people affected by the virus. The studies that come from this work will tell us a lot more about the genetics of viral infections. While we dont know the immediate impact the current COVID-19 pandemic, we intend to be better armed with knowledge of the behaviour of this virus, which will help us to be better prepared for future pandemics.

Project collaborators include Dr. Richard Harrigan, professor in the UBC department of medicine, Dr. Marco Marra, head of the UBC department of medical genetics and director of Canadas Michael Smith Genome Science Centre at the BC Cancer Research Institute, and Dr. Naveed Aziz, chief administrative and chief scientific officer at CGEn.

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UBC scientists sequencing the genomes of Canadians with COVID-19 - UBC Faculty of Medicine

Trends: To have or not to have a baby childless author Emma Gannon is blazing a trail for choice – Metro Newspaper UK

Posted on July 26, 2020 by Danzig

AT THE age of 51, Jennifer Aniston is a wealthy movie star beloved by fans across the globe with an enviable jet-set lifestyle and a career she relishes. Why then, has she been portrayed for years as someone to be pitied because she hasnt cradled her own baby in her arms?

In a candid moment six years ago, Aniston told Allure magazine, I dont like [the pressure] that people put on me, on women that youve failed yourself as a female because you havent procreated.

Despite her status and celebrity, Aniston is far from alone. Her treatment reflects societys view that having a child is the right and valid thing to do and that, by implication, choosing not to is wrong.

So, kudos to Emma Gannon, best known for the Ctrl, Alt, Delete podcast and business book The Multi-Hyphen Method, for creating a titular character in her first novel, Olive, who doesnt want to be a mother by choice.

In 2018, the Office for National Statistics revealed 19 per cent of women whod reached 45 did not have children; a proportion thats doubled in a generation, so the books themes will no doubt resonate with many women whove been maligned because theyre not mothers.

Kim Cattrall [Samantha in Sex And The City] inspired me. I read an article where she said you must say childfree, not childless. Cattralls another woman who takes up a lot of space in the world but because shes not married or has children, people turn their nose up at her and I just think that needs to change, says Gannon, 31, whos known for a long time she doesnt see herself having children and was keen to find other women who felt the same.

I really dont have that formula in my head that having a child will make me feel complete. I feel complete and I just want women out there who feel the same to know that is valid. Its very different to someone who might be in pain because they havent had the child they always wanted. This is a choice. Maybe we just need to reframe what this strange definition of having it all actually means because I personally think I have it all, says Gannon, who studied English and film at Southampton University before moving to London and getting a job in a big shiny PR agency.

Its something she regards as invaluable given shes created her own brand out of a blog she started at 20 and was named one of Forbes 30 Under 30 in 2018.

Its never really appealed to me to follow the crowd. I didnt follow the one, two, three-step guide to a successful job, I made my own career, so Im OK with staying away from what people think is the norm. Im lucky I dont have any judgement from my parents or friends. Maybe there are women who find it harder to break away and feel judged, and for some people, saying, I dont want children is a bigger thing.

But when Gannon turned to social media to find those who felt the same way she discovered she was far from alone.

I tweeted I was looking for women who were childfree by choice and got about 200 replies in minutes and then my emails blew up and I realised my feelings were very much those of others. There was no sense of shame or victimisation. It wasnt poor us, it was more, were here and unapologetic about our life choices and can someone shine a light on us? I knew this was going to be my first novel.

The book is about four lifelong friends in their early 30s, Olive, Bea, Isla and Cec, who are facing the inevitable issue of motherhood, but in markedly different ways.

Olive thinks her friends are being selfish because all they talk about is their children. They think Olive is being selfish because shes quite rightly obsessed with her own feelings and break-up and then youve got Isla going through IVF and is incredibly self-absorbed, which she has every right to be because shes going through a traumatic time. They all have struggles, all make mistakes, and are all insensitive at times, says Gannon, who adds she isnt Olive, but writing this novel is the closest Ive got to expressing myself in the truest way.

And its through Olives experiences Gannon reflects the reality for many childfree women.

As part of her research, she asked the women about the most irksome remarks theyre subjected to.

It was the same across the board Whos going to look after you when youre old? Arent you scared youre going to be lonely? Wont you regret it? Dont you want to leave behind a legacy? It was scaremongering, says Gannon. Then theres the belief that childfree women are out partying every night without a care in the world.

Im getting married next year, and we stay home a lot. I love nesting. And Im not this person who has all this endless amount of time. I have other commitments. Thats something I really wanted to show in the book, that just because someone is childfree, theyre not gallivanting around town.

Gannon hopes her book will prompt honest conversation, and show theres nothing wrong with taking your time to make up your mind about what you want in your life.

A lot of women fall into having children because their mother and grandmother did and there are a lot of women out there who think, Hmm, I dont know whether I wouldve done this differently, and thats OK as well, she says.

I think were too quick to judge people for their decisions, even our friends sometimes. Were all just figuring out our own way, whatever path we choose.

Researchers predict the worlds population will peak at 9.7 billion around 2064, before falling down to 8.8 billion by the end of the century.

If the fertility rate falls below approximately 2.1, then the size of the population starts to fall.

The average number of children a woman gives birth to is falling, due to more women being in education and work, and more access to contraception. Researchers at the University of Washingtons Institute for Health Metrics and Evaluation showed the global fertility rate nearly halved between 1950 and 2017.

The University of Washingtons study predicts that by 2100, the rate will fall below 1.7. With 23 nations including Spain, Portugal, South Korea and Japan expected to see populations halve by 2100.

I realised that so much of the pressure I was feeling was from outside sources and I knew I wasnt ready to take that step into motherhood Kim Cattrall

If I had kids, theyd hate me. Theyd end up on a show talking about me; because something [in my life] would have had to suffer and it wouldve probably been them Oprah Winfrey

You have to really want to have kids and neither of us did Portia de Rossi

As a comic, always working and on the road, I have had to decide between motherhood and living my fullest life and I chose the latter Sarah Silverman

Motherhood has never been an ambition. I dont think like that Rene Zellweger

Having children was not my destiny, I kept thinking it would be, waiting for it to happen, but it never did and I didnt care what people thought Helen Mirren

Olive by Emma Gannon (HarperCollins) is out now

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Trends: To have or not to have a baby childless author Emma Gannon is blazing a trail for choice - Metro Newspaper UK

COVID19 Impact- Global Repair Tire Sealant Market Recent Industry Developments and Growth Strategies Adopted by Top Key player Slime, Bikeradar,…

Posted on July 26, 2020 by Danzig

Global Repair Tire Sealant Market: Trends Estimates High Demand by 2027

Repair Tire Sealant Market report 2020, discusses various factors driving or restraining the market, which will help the future market to grow with promising CAGR. The Repair Tire Sealant Market research Reports offers an extensive collection of reports on different markets covering crucial details. The report studies the competitive environment of the Repair Tire Sealant Market is based on company profiles and their efforts on increasing product value and production.

Repair Tire Sealant research study involved the extensive usage of both primary and secondary data sources. The research process involved the study of various factors affecting the industry, including the government policy, market environment, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers, and challenges.

The final report will add the analysis of the Impact of Covid-19 in this report Repair Tire Sealant industry.

Adapting to the recent novel COVID-19 pandemic, the impact of the COVID-19 pandemic on the global Repair Tire Sealant market is included in the present report. The influence of the novel coronavirus pandemic on the growth of the Repair Tire Sealant market is analyzed and depicted in the report.

Some of the companies competing in the Repair Tire Sealant market are: Slime, Bikeradar, LiquiTube, Berryman, Quadboss, Ride-On, Orange Seal, and Fix-A-Flat

Get a Sample Copy of the [emailprotected] https://www.reportsandmarkets.com/sample-request/global-repair-tire-sealant-market-research-report-2020?utm_source=primefeed&utm_medium=34

The report scrutinizes different business approaches and frameworks that pave the way for success in businesses. The report used Porters five techniques for analyzing the Repair Tire Sealant Market; it also offers the examination of the global market. To make the report more potent and easy to understand, it consists of info graphics and diagrams. Furthermore, it has different policies and development plans which are presented in summary. It analyzes the technical barriers, other issues, and cost-effectiveness affecting the market.

Global Repair Tire Sealant Market Research Report 2020 carries in-depth case studies on the various countries which are involved in the Repair Tire Sealant market. The report is segmented according to usage wherever applicable and the report offers all this information for all major countries and associations. It offers an analysis of the technical barriers, other issues, and cost-effectiveness affecting the market. Important contents analyzed and discussed in the report include market size, operation situation, and current & future development trends of the market, market segments, business development, and consumption tendencies. Moreover, the report includes the list of major companies/competitors and their competition data that helps the user to determine their current position in the market and take corrective measures to maintain or increase their share holds.

What questions does the Repair Tire Sealant market report answer pertaining to the regional reach of the industry

The report claims to split the regional scope of the Repair Tire Sealant market into North America, Europe, Asia-Pacific, South America & Middle East and Africa. Which among these regions has been touted to amass the largest market share over the anticipated duration

How do the sales figures look at present How does the sales scenario look for the future

Considering the present scenario, how much revenue will each region attain by the end of the forecast period

How much is the market share that each of these regions has accumulated presently

How much is the growth rate that each topography will depict over the predicted timeline

The scope of the Report:

The report segments the global Repair Tire Sealant market on the basis of application, type, service, technology, and region. Each chapter under this segmentation allows readers to grasp the nitty-gritties of the market. A magnified look at the segment-based analysis is aimed at giving the readers a closer look at the opportunities and threats in the market. It also address political scenarios that are expected to impact the market in both small and big ways.The report on the global Repair Tire Sealant market examines changing regulatory scenario to make accurate projections about potential investments. It also evaluates the risk for new entrants and the intensity of the competitive rivalry.

Reasons for Read this Report

This report provides pin-point analysis for changing competitive dynamics

It provides a forward looking perspective on different factors driving or restraining market growth

It provides a six-year forecast assessed on the basis of how the market is predicted to grow

It helps in understanding the key product segments and their future

It provides pin point analysis of changing competition dynamics and keeps you ahead of competitors

It helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments

TABLE OF CONTENT:

Chapter 1: Repair Tire Sealant Market Overview

Chapter 2: Global Economic Impact on Industry

Chapter 3: Repair Tire Sealant Market Competition by Manufacturers

Chapter 4: Global Production, Revenue (Value) by Region

Chapter 5: Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6: Global Production, Revenue (Value), Price Trend by Type

Chapter 7: Global Market Analysis by Application

Chapter 8: Manufacturing Cost Analysis

Chapter 9: Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10: Marketing Strategy Analysis, Distributors/Traders

Chapter 11: Repair Tire Sealant Market Effect Factors Analysis

Chapter 12: Global Repair Tire Sealant Market Forecast to 2027

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COVID19 Impact- Global Repair Tire Sealant Market Recent Industry Developments and Growth Strategies Adopted by Top Key player Slime, Bikeradar,...

The 1 Reason a Wooden Deck May Be a Better Choice Than Composite – Motley Fool

Posted on July 26, 2020 by Danzig

Adding a deck to your property is a smart move that could pay off in different ways. But not all decking material is created equal, and these days, many homeowners are opting for composite decking over classic wood. The reason? Composite is much easier to maintain. But in spite of that, it could still pay to opt for a wooden deck, especially if you're flipping a house or preparing your own house to sell.

The average cost to add a wooden deck onto a home is $14,360, according to Remodeling Magazine's most recent Cost vs. Value Report. By comparison, the average composite deck costs $19,856. As such, there's a lot of upfront savings to be reaped when you choose wood over composite.

But that's not all. From a return on investment perspective, wood is also a better choice. The average homeowner or house-flipper who installs a wooden deck will recoup $10,355, or 72.1% of that project's initial cost. By contrast, with composite decking, the average amount recouped is $13,257, representing a cost recovery of 66.8%. As such, if your primary goal in installing a deck is to add to your home's resale value and recoup the largest chunk of your investment, then wood may be the smarter choice.

From an investment perspective, it's clear that wood decking over composite is a good bet. But what if you're not flipping or selling a house? What if you're installing a deck for your own enjoyment? In that case, it could actually pay to choose composite.

Wood decking requires a lot of ongoing maintenance. You need to seal and sand it every year and paint or stain it every other year. You'll also need to pressure-wash your deck every year, and sometimes more frequently than that. If you don't maintain your wooden deck properly, it can warp, splinter, and even rot through completely, resulting in a major hazard.

Composite decking, on the other hand, requires very little maintenance. You may need to pressure-wash it every year, but that's really about it. In fact, over time, you're apt to spend a lot less money maintaining a composite deck than a wooden deck. If you're adding a deck and selling your property shortly after the fact, that's not a concern, as you won't be the one stuck with that maintenance. But if you're planning to stay in your home for a long time, then you may be better off spending more on composite and saving yourself the money and hassle over time.

Of course, if you happen to prefer the look of wood, then you might opt for it anyway in spite of that maintenance. Aesthetics should play a role in your decision, too.

Ultimately, any type of deck is a good addition to your home. It can help you better enjoy your outdoor space and add to your property's resale value. While wood decking may offer a better return on investment, if that's not your primary concern, then composite may be a more suitable choice.

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The 1 Reason a Wooden Deck May Be a Better Choice Than Composite - Motley Fool

This saucy, smothered tofu with peppers and onions will have you dreaming of the Mexican coast – Borneo Bulletin Online

Posted on July 26, 2020 by Danzig

Joe Yonan

THE WASHINGTON POST Mexican cuisine, said Eddie Garza, doesnt have to be all about cheese, meat and lard. In his 2016 cookbook, Salud!, he points to pre-Hispanic Mesoamericas big focus on fruits, vegetables, legumes and grains. As his grandmother told him, Before the Spanish came to Mexico, food was provided by the Sun and Earth.

The son of Mexican immigrants who grew up in a border town at the southern tip of Texas, Garza now works for the Humane Society of the United States, where he helps reform food systems in Latinx communities and trains cooks in the joys of plant-based recipes. I first started cooking from Garzas book because his adaptations of traditional dishes are rooted in a deep understanding of Mexican cooking instilled by his abuelita. And the results have never disappointed me.

Theyre not all pre-Hispanic, either. My latest obsession is his Tofu Steak Veracruzana, seared cutlets smothered in a classic Veracruz-style salsa that includes bell peppers, tomato, olives, capers and white wine. Those capers and olives, he writes, represent some of the European ingredients that came to characterise the coastal states cooking, along with tropical fruit and, of course, seafood.

Tofu, famous for its mildness, works well with the salsas tart, salty, slightly spicy punch.

But Garza adds flavour wherever he can, so before you sear it and sauce it, you treat the tofu to a lime-heavy marinade. Theres nothing fishy about that.

TOFU STEAK VERACRUZANA

Active: 30 minutes | Total: one hour

Four servings

Seared tofu cutlets get a classic coastal Mexican treatment usually reserved for seafood. Serve with rice and/or a green salad, if youd like.

INGREDIENTS

One package water-packed extra-firm tofu, drained

Two garlic cloves, finely chopped, divided

1/4 cup homemade or low-sodium store-bought vegetable broth

1/4 cup fresh lime juice

One teaspoon dried Mexican oregano

1/2 teaspoon kosher salt, plus more to taste

1/2 teaspoon freshly ground black pepper, plus more to taste

One tablespoon vegetable oil

One medium red onion, thinly sliced

One medium red bell pepper, stemmed, seeded and thinly sliced

One jalapeo chile pepper, stemmed, seeded and thinly sliced

1/2 cup pitted green olives, chopped

1/4 cup capers, drained, rinsed and chopped

Three large plum tomatoes, seeded and thinly sliced

One tablespoon vegan butter, such as Miyokos or Earth Balance

STEPS

Wrap the tofu in paper towels or a clean dish towel and microwave on high for one minute.

Unwrap, rewrap with fresh towels, and repeat. (This gets rid of excess liquid and is faster than pressing the tofu.)

Unwrap, let cool, and cut into four planks.

Combine the tofu, half the garlic, the stock, lime juice, oregano, salt and pepper in a large bowl or zip-top bag.

Cover or seal and marinate at room temperature for 30 minutes to one hour, turning occasionally. (If desired, you can marinate the tofu in the refrigerator for up to 24 hours.) Drain the tofu and reserve the marinade for another use.

In a cast-iron skillet over medium-high heat, heat the oil until shimmering. Add the drained tofu and sear it without disturbing until well browned, four to six minutes.

Turn each piece over, and sear on the other side until browned, about four minutes. Transfer to a plate.

Add the onion, bell pepper and jalapeo to the skillet and cook, stirring, until they start to soften, about four minutes.

Stir in the olives, capers and the remaining garlic and cook, stirring, until all the vegetables are tender, about three minutes.

Add the tomatoes. Reduce the heat to medium, return the tofu to the skillet, and cook until the sauce reduces slightly and the tofu is heated through, about five minutes.

Stir in the butter, then taste and season with additional salt and pepper, if desired.

To serve, either leave the tofu planks whole or slice them on the bias, and spoon over the sauce and vegetables. Serve hot.

Empire Metals slides as Munni Munni transaction is threatened – Proactive Investors UK

Posted on July 26, 2020 by Danzig

Empire Metals Limited (), the resource exploration and development company, lost a quarter of its value at 2.3p following an announcement by Aussie miner Artemis Resources.

Empire has previously announced its intention to acquire from Artemis a 58.6% interest in Munni Munni, a wholly-owned subsidiary of Artemis that holds a 70% interest in the Munni Munni Palladium Project.

Platina, Artemiss 30% joint venture partner in the Munni Munni Project, has started legal proceedings against Artemis because it claims the proposed sale of a controlling interest in its Munni Munni subsidiary breaches the joint venture agreement.

AstraZeneca PLC () was the best performing blue-chip, up 2.8% at 9,255p, after promising developments on an experimental coronavirus vaccine.

The vaccine, which is being developed by Oxford University in collaboration with AstraZeneca, has proved safe with some signs of efficacy in its first human trial.

More than 1,000 people took part in the trial, with signs that the vaccines boosted both antibodies and cells to fight the virus.

1.00pm: Pensana Rare Earths surges after finding potential partner for its Longonjo Project

(LON:PRE) climbed 12% to 24p after entered into a heads of agreement with China Great Wall Industry Corporation.

The two will cooperate on Pensanas rare earths Longonjo Project in Angola.

China Great Wall is a company with expertise and experience in international engineering that is actively engaged in a range of engineering projects in Africa.

(), up 311% at 150p, was easily the top riser in London after it announced heartening results of a potential coronavirus treatment.

Chief executive Richard Marsden said positive results from a clinical trial of its drug to tackle the severe symptoms of coronavirus (COVID-19) could signal a major breakthrough in the treatment of hospitalised patients.

People who received SNG001, an inhaled formulation of interferon beta had a 79% lower risk of developing a severe disease compared to those given the placebo, the data revealed. They were also more than twice as likely to recover from the illness than those receiving the substance with no therapeutic value.

UK Mortgages Limited (LON:UKML) advanced 14% to 63p after it emerged it had rebuffed several bid approaches from M&G Investment Management Limited.

The most recent approach was made on July 15 and proposed a cash offer at 67p per share.

M&G said the board of UkMortgages has declined to enter into discussions that might lead to a firm offer being made and has, therefore, made the bid approaches public to allow shareholders to decide for themselves on the merits of the possible offer.

() has been granted vehicular access to its Lahtojoki diamond deposit, sending the shares 35% higher at 2.85p.

The granting of vehicular rights of way by the National Land Survey of Finland will facilitate the company in its technical assessment of the Lahtojoki diamond deposit over which it has been granted a mining concession.

The two-hectare Lahtojoki diamond deposit is located in the Kaavi region of Eastern Finland and lies in the Karelian Craton which extends across north-eastern Russia and northern Finland. The world-class Lomonosov and Grib Pipe diamond deposits have been discovered in the Russian sector of the Craton.

Sealand Capital Galaxy Limited () sank 6.1% lower to 1.55p in early trade on Monday despite announcing a contract win for its ePurse subsidiary.

Epurzse has signed a 24-month strategic partnership with JM International, the Hong Kong company behind the Qiaohuajiao brand, which includes a variety of fish maw products, used in numerous industries, such as health, cosmetics and food production.

ePurse has successfully helped JM International to enter Tmall International, an online marketplace that is part of the .

Haydale Graphene PLC (), however, climbed 6.3% higher to 4.2p after it signed an exclusive distribution agreement with US-based Zirconia Inc.

The agreement is for 30 months and allows Haydale full distribution rights of Zirconias CeramycShield geopolymers in the UK water infrastructure sector. The plan is to address previously unsolvable water infrastructure problems in the UK.

Zirconia's patented Ceramic Surface Treatment technology is a new, advanced material technology, in a new class of inorganic ceramic polymers, that uses Haydale's silicon carbide microfibre as a reinforcement. This technology has now been commercialised by Zirconia in the US where the products are readily available.

() chief executive Richard Marsden said positive results from a clinical trial of its drug to tackle the severe symptoms of coronavirus (COVID-19) could signal a major breakthrough in the treatment of hospitalised patients. People who received SNG001, an inhaled formulation of interferon beta had a 79% lower risk of developing a severe disease compared to those given the placebo, the data revealed. They were also more than twice as likely to recover from the illness than those receiving the substance with no therapeutic value. A total of 101 people took part in the clinical assessment at nine sites between March 30 and May 27.

s () Cascadura project has been confirmed as a significant discovery in a new independent reserves report. Consultant GLJ Ltd has estimated Cascadura hostsbetween 241.2 and 571.5 billion cubic feet of discovered natural gas in place, with the best estimate pitched at 398.5bn. GLJ gives the project some 73,19mln barrels of oil equivalent (boe) reserves in the 3P (proved, probable, possible) category, with 2P (proved and probable) reserves set at 45.03mln boe and theres 23.62 boe of proved reserves. The reserves are valued by GLJ in a range between US$802.9mln and US$287.7mln, with 2P reserves valued at US$519.2mln.

Shanta Gold Ltd () produced 22,216 ounces of gold from its New Luika mine in Tanzania during the second quarter of 2019, up on the 20,167 ounces produced in the first quarter. Free cash flow amounted to US$15.5mln, up from US$3.9mln in the first quarter. The company said it has also been working up the resource at Singida, which now stands at 243,000 ounces.

() said a decision to focus in-house activities on its retinal disease and exosome-based programmes will provide significant near-term opportunities to deliver value-enhancing data and commercial partnerships as it updated on the progress of its various treatments. In its results for the year ended March 31, 2020, the cell-based therapeutics firm said its hRPC stem cell therapy candidate for the retinal disease had delivered positive and sustained top-line efficacy data in an ongoing US Phase 1/2a clinical trial, with further readouts from an expanded study expected over the next 12 months, leading to intention to file an application in the second half of 2021 to commence a pivotal clinical study. The company also said it has received regulatory approval in the US and UK to expand the Phase 2a study to allow for a subsequent potential single pre-approval clinical study and shorter route to market.

MTI Wireless Edge Ltd () said its Mottech Water Solutions subsidiary has launched a new wireless irrigation solution developed for the French wine market. The system, dubbed Tethys, already has a customer list of 200 French vineyards since it is used by four water associationswho provide irrigation services to the wine producers. The Tethys water management system enables accurate water distribution and irrigation management, resulting in a 30% increase in crop yields while reducing costs by around 30% from efficient use of water, fertiliser, energy and labour, MTI Wireless noted.

Alien Metals Limited () has said finalisation of the geophysical review for the Donovan 2 copper-gold project in Mexico is essentially complete. The company is hoping to finalise the upcoming drill programme at Donovan 2 at the end of next week. The independent review confirms the company's internal work, providing some priority targets that have the potential to delineate hidden copper-gold mineralisation. The company said it will push ahead with drill planning in the third quarter of this year.

() said the first half of 2020 saw all of its divisions make progress towards its goal of being profitable this year. The functional fibres division reported a profit during this period, the ProBiotix division was profitable in three of the six months, and the consumer health division was profitable in one of the six months, OptioBiotix told investors. Total invoiced sales of LPLDL and SlimBiome as an ingredient or final product shot up by 398% to 741,504 from 148,818 in the first half of last year.

() said its first-half trading was in line with forecasts with momentum continuing into the second six months of the year. The software group, which has developed and sells packages used to record R&Ddata, said revenues for the six months ended June 30, 2020, were up 20%, or 12% on a like-for-like basis. Cash generation was strong, leaving Instem with 9.1mln, which when added to the 15.75mln raised earlier this month leaves it with significant capital to accelerate its acquisition strategy. It said it has many potential compelling opportunities for bolt-on deals, with more substantial targets havealso been identified.

() has welcomed legal changes to allow battery projects larger than 50Mw in England and 350Mw in Wales. The new legislation removes energy storage, except pumped hydro, from the Nationally Significant Infrastructure Projects regime in England and Wales, said the fund. This will allow larger projects to receive planning permission without government approval.

() said the results of a new study from the University of Southern California (USC), published in the International Journal of Molecular Sciences, have highlighted the key advantages of its Parsortix liquid biopsy system compared to a standard of care tissue biopsy. The AIM-listed firm said in addition to the known advantages of a non-invasive, repeatable and low-cost procedure, the USC study showed that potential actionable therapeutic targets were found in the Parsortix biopsy that were missed in the tissue biopsy of a single metastatic site.

() has been granted rights of way over the entire Naviskangas private forest road, together with a side road, giving vehicular access to the companys Lahtojoki diamond deposit, the adjacent Lahtojoki South exploration permit area and the surrounding reservation in the Kaavi region of Finland. The granting of vehicular rights of way by the National Land Survey of Finland will facilitate the company in its technical assessment of the Lahtojoki diamond deposit over which it has been granted a mining concession. The two-hectare Lahtojoki diamond deposit is located in the Kaavi region of Eastern Finland and lies in the Karelian Craton which extends across north-eastern Russia and northern Finland.

() has updated on its operations, revealing that drilling of the Duff well at the Greater Stanley projectwill start in the fourth week of July. Additionally, the group said, results of a workover in the Stanley-1 well are expected shortly and preparations are underway for the Falcon-1 well with site works due in late August ahead of drilling in September.The project operator is also planning the proposed Stanley-4 well.

() has booked A$903,215 in second quarter royalty payments from the Koolyanobbing iron ore project in Australia. The increased payment is a result of strong iron ore prices, as well as the continued ramp-up of operations at Koolyanobbing. The iron ore price increased significantly over the second quarter, rising by 19% to US$99.4 per tonne from US$83.3per tonne, with an intra-month peak of US$105.7 per tonne. Whats more, that price trend has continued into the third quarter, with spot prices reaching US$112 per tonne in mid-July.

() has completed its due diligence concerning the Hope copper project in Namibia, and the parties are now proceeding to the administrative process of completing the acquisition. As announced onJune 19, 2020, theacquisition of 100% of Virgo Resources Ltd and its interests in the Hope copper-gold project in Namibiawas subject to certain conditions precedent, including completion of due diligence, regulatory consents for Bezant to proceed, and execution. "The completion of our corporate and technical due diligence on the acquisition of Virgo and its +70% interest in the Hope gold-copper project is an important milestone for Bezant, executive chairman Colin Bird said in a statement.

Bezant Resources also said its annual general meeting (AGM) will be held at 7/8 Kendrick Mews, South Kensington, London SW7 3HG, England, at 10.00am. on Monday, August 10, 2020. In light of current restrictions on public gatherings and to ensure shareholders can comply with the government measures, the company has concluded that shareholders will not be permitted to attend in person and therefore requests that shareholders cast their votes by proxy 48 hours in advance of the AGM.

() said theMinto copper mine in the Yukon, Canada, which it partially owns, produced 6,820 wet metric tonnes of concentrate during the second quarter of 2020. Payments of US$9.8mln were received by Minto from its major customer Sumitomo, itadded. The next shipment to Japan is planned before the end of the third quarter, based on current production levels.

() () (OTCQB:NQMIY) said it has appointed Deutsche Gesellschaft fr Wertpapieranalyse GmbH (DGWA - the German Institute for Asset and Equity Allocation and Valuation), a mining and resource focused European investment banking boutique, as its Investor and Corporate Relations advisor in Europe. With offices in Frankfurt, Berlin and Vienna as well as representatives in Australia and Canada, NQ said DGWA will focus on the growing interest in mining and exploration within the European financial community due to Europe's considerable investment commitments in the clean energy, electric vehicle and energy storage systems industry.

() said its BlackOak Alpha Growth Fundhad seen a significant rise in interest since April though there has been an impact from the coronavirus (COVID-19) disruption. Several major US registered investment advisors, or RIAs, havenow moved to the next step of conducting due diligence on the BlackOak fund, it added. Alpha Growth hasalso started discussions with certain proprietary funds to manage the longevity assets within those funds through separately managed accounts. Longevity assets are life insurance policies sold before the maturity date to a third party for cash.

() (CSE:XOP) said it has raised 1.3mln in a share placing and has also reached a debt exchange agreement with creditors. The placing investors comprise two institutions and two high net worth investors. Some 621mln new shares will be issued, at a price of 0.3p each. In the proposed debt exchange transaction, the company will issue around 411mln new shares as settlement of debts to unsecured creditors, along with accrued payments due to employees and management.

Galantas Gold Corporation () (), the gold producer and explorer with a 100% interest in Northern Ireland's Omagh gold mine said its proposed private placement for 2,833,132 common shares for gross proceeds of C$637,454 (376,240), previously announced on June 26, 2020, and July 03, 2020, has now closed and was fully subscribed. A four-month hold period will apply to the common shares issued under the private placement which will expire on November 18, 2020.

(LON: CTEA), the AIM-quoted provider of digital media and technology, has announced that Guy Meyer, its interim chief executive officer, has taken on the role of permanently with immediate effect. The firm also said it has conditionally granted options to certain directors over 15,631,579 new ordinary shares, with all of the options having an exercise price of 3.8p: Meyer has been conditionally granted options over a maximum of 11,578,947 new ordinary shares (representing a maximum of 5.34% of the current issued capital of the company); John Farthing, its chief financial officer, has been conditionally granted options over a maximum of 4,052,632 new ordinary shares (representing a maximum of 1.87% of the current issued capital of the company).

() (), a global, commercial-stage biopharmaceutical company dedicated to developing and commercializing novel therapeutics to treat patients suffering from serious and lie threatening rare diseases has said it will issue its unaudited financial results for the second quarter ended June 30, 2020, on August 6, 2020, at 12.00pm BST. It added that management will host a webcast for analysts and investors on August 6 at 1.30pm BST.

() has said its annual general meeting will be held at 12.00pm BST on August 5, 2020, at the offices of Novum Securities, 8-10 Grosvenor Gardens, Belgravia, London, SW1W 0DH. Whilst the UK government's current social distancing rules and guidelines remain in place, no shareholders will be permitted to attend the meeting in person and any shareholder who attempts to attend the meeting in person will have to be refused entry.

Quadrise PLC () announced that its chairman, Mike Kirk, and CEO, Jason Miles, will provide a live presentation at a Shares & AJ Bell investor evening webinar on Tuesday, July 21, 2020. It will be the first of four companies presenting, each having a presentation slot followed by Q&A, with the webinar taking place from 6.00pm BST. The group said no new material information will be disclosed at the presentation and a copy of the company's updated presentation being provided will be available on the Quadrise website on the evening of Tuesday, July 21, 2020.

Hardman & Co Research has issued a research note on (), a long-established specialist in the prevention, diagnosis and treatment of allergies. It noted that another reassuring trading update stated that the company has hit new records and has the resources in place to fund its pending R&D investment programme required to get its products approved by the regulators. The research report can be viewed at: https://www.hardmanandco.com/research/corporate-research/record-sales-and-a-covid-19-wildcard/

Empire Metals slides as Munni Munni transaction is threatened - Proactive Investors UK

Lovina’s Amish Kitchen: Wedding memories and Mother’s raisin pie – Traverse City Record Eagle

Posted on July 26, 2020 by Danzig

July 15 was our 27th anniversary. Lots of memories throughout the years since Joe and I were married.

This is what my mother wrote in her column in July 1993 about our wedding. Mother wrote:

The weather was ideal for the wedding of daughter Lovina to Joe Eicher. Lots of work at such a time.

The Tuesday before the wedding, which was Thursday, July 15, about two dozen women came to help. They baked 90 pies (oatmeal, cherry, raisin, and rhubarb) and made 14 batches of nothings. Didnt really want that many pies, but that number came upon us before we knew or thought of it. Well anyways no worry to run out of pies.

Wednesday about a dozen girls came to peel potatoes, cut up vegetables for the dressing and make potato salad for which I had cooked a twenty-quart cooker full of potatoes. Also, the tables were set and the last minute cleaning done. Our wash house or shed saw lots of life out there, as all the work was done in there to prepare for the wedding ceremony. Wednesday evening quite a few of our friends came to see the wedding tables, and refreshments were served to the ones that came. It was an enjoyable evening.

Then came the wedding day. We started to fry chicken (300 pounds) at 4:15 a.m. which was served for dinner. Had enough for supper too and also served boneless ham. Our meals consisted of chicken and noodles, gravy, mashed potatoes, dressing, chicken, buttered corn, green beans (which came out of our garden), pork and beans, potato salad, carrot salad, lettuce salad (plenty from the garden), hot peppers, Swiss cheese, fruit salad, tapioca pudding, pies, cakes, nothings, celery sticks, coffee, bread, rhubarb jam, and butter. There were around 18 skillets used to fry the chicken. We cooked 3 twenty-quart cookers of potatoes for dinner for mashed potatoes and 2 twenty-quart cookers for chicken and noodles. In the afternoon we again cooked over 3 twenty-quart cookers of potatoes to be mashed and more chicken and noodles for supper. Also 16 quarts of gravy. There were 28 women to prepare the meals. We could seat 98 people in the house and 70 in the wash house. The tool shed was cleaned out where the wedding services were held and later used to set up a table for the children for the noon and evening meals. We had quite a crowd here for both meals. Well enough of this for now. What a relief to have it over with.

I have so many precious memories of mother and how much she did for her family. Joe was called back in to work this week after being laid off since March 23. It sure is a relief to us to have his income coming in again.

Yesterday, son Benjamin turned 21, so he wanted the family to come home for supper. He ordered out pizza and wings for all of us. What a treat is was! Chips, cheese ball and crackers, and ice cream were also added to the menu. I didnt get time to make a cake and didnt for daughter Lorettas birthday either. With son Josephs birthday coming up next week, it looks like we will have one cake for all the July birthdays. Its almost too much cake for one month if we have three. Benjamin said he wouldnt eat cake anyway, so he didnt care that there wasnt a cake.

Since I am running out of space, I will write about our family gathering at sister Leah and Pauls house next week. I will share the recipe for Mothers raisin pie. God bless!

2 (8-inch) unbaked pie crusts

1 C. raisins

2 T. clear gelatin

pinch of salt

1 C. sugar

1 T. apple cider vinegar

1 C. water

Preheat the oven to 400 degrees. Use one crust to line an 8-inch pie pan. Cook the raisins with water to cover in a kettle over medium heat until plump and juicy, about 15 to 30 minutes. In a bowl, make a thickening with the gelatin, salt, sugar, vinegar, and water. Pour into the raisin mixture. Cook until the mixture is thick enough to stick to a spoon. Add more sugar if it is not sweet enough for you. Pour into the pie shell. Cover the top with the remaining pie crust and seal and flute the edges. Cut slits in the center for steam to escape. Bake for 30 minutes, until the top is golden brown. Makes 1 (8-inch) pie.

We are making critical coverage of the coronavirus available for free. Please consider subscribing so we can continue to bring you the latest news and information on this developing story.

Lovinas Amish Kitchen is written by Lovina Eicher, Old Order Amish writer, cook, wife, and mother of eight. Readers can write to Eicher at PO Box 1689, South Holland, IL 60473 (please include a self-addressed stamped envelope for a reply); or email LovinasAmishKitchen@MennoMedia.org and your message will be passed on to her to read. She does not personally respond to emails.

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Lovina's Amish Kitchen: Wedding memories and Mother's raisin pie - Traverse City Record Eagle

Third Parties Not Responsible for Defective Motion to Seal – JD Supra

Posted on July 26, 2020 by Danzig

The US Court of Appeals for the Federal Circuit held that a district court did not abuse its discretion in denying reconsideration of a previous order denying a litigants defective motion to seal with regard to the litigants own information, but vacated and remanded for further consideration with regard to third-party information. Uniloc 2017 LLC v. Apple, Inc., Case Nos. 19-1922, -1923, -1925, 1926 (Fed. Cir. July 9, 2020) (Mayer, J.).

Uniloc sued Apple for patent infringement in the Northern District of California. Apple moved to dismiss. The briefing on the motion included material that Uniloc had designated as highly confidential. Both parties filed motions to seal. Unilocs motions to seal covered quotations from published opinions and matters of public record, among other things. Unilocs supporting declarations included only boilerplate assertions of harm from disclosure. Non-party Electronic Frontier Foundation asked Uniloc to narrow its redactions, and when Uniloc declined, Electronic Frontier moved to intervene for the purpose of opposing Unilocs sealing motions. The district court denied the motions to seal as overbroad under the local rules, which require such motions to be narrowly tailored.

Uniloc sought an extension of time and ultimately filed a motion for leave to seek reconsideration. In that motion, it agreed to make public more than 90% of the material it had originally sought to seal. It also filed a new motion to seal the remainder. In support, it attached a much more specific declaration supporting sealing the more limited set of materials, as well as several declarations of third-party licensees, who stated that disclosure of their confidential information would be harmful to them. The court denied the motion seeking leave as not meeting the local rules requirements for reconsideration. The court also denied the narrower motion to seal, reasoning that Uniloc should have filed a proper motion to seal in the first instance. Uniloc appealed.

Uniloc argued that the district court had abused its discretion in denying the narrower motion to seal. In considering Unilocs argument, the Federal Circuit distinguished between Unilocs information and third-party information. Applying Ninth Circuit law, the Court held that the district court had not abused its discretion by strictly enforcing its local rules with regard to Unilocs information. Uniloc had violated the local rules in its motion to seal and subsequent motion for reconsideration. Moreover, the Court explained that notwithstanding the submission of a narrowly tailored motion, the burden is always on the moving party to provide compelling reasons for sealing, which Uniloc had failed to do.

Next, the Federal Circuit explained that third-party information calls for an analysis not dependent on the overbreadth rationale because third parties should not be harmed by a litigants failure to follow the local rules. Because the district courts analysis had been based on overbreadth, the Court found that the district court failed to make findings sufficient to allow us to adequately assess whether it properly balanced the publics right of access against the interests of the third parties in shielding their . . . information from public view. It thus remanded to the district court for further consideration of this issue.

Practice Note: In dicta, the Federal Circuit notified the bar that it considered overbroad motions to seal to be a problem in patent litigation, and characterized the district court as having sent a strong message that litigants should submit narrow, well-supported sealing requests in the first instance. Parties should narrowly tailor requests to seal and support such requests with declarations identifying specific harms stemming from the disclosure of the particular information sought to be sealed as well as the parties efforts to keep the information secret.

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Third Parties Not Responsible for Defective Motion to Seal - JD Supra

Maintaining a rhythm of devout prayer and reflection at Lough Derg – Derry Now

Posted on July 26, 2020 by Danzig

The prior of Lough Derg, Father La Flynn who is spending this pilgrim season on the island feels at ease with being alone as he continues to maintain a tradition of prayer in St Patricks Purgatory.

Father La rises in the morning at around 5.40am for early morning Mass.

Less than an hour later, he is under an open sky as birds fly overhead undertaking the Stations in his bare feet leaving solitary footprints where before many soles left their imprint on the earth.

Housemartins

A station takes around an hour and ten minutes to do and Father La does so under the swooping wings of the Housemartins amidst a backdrop of blooming nature during these calm but drizzly mornings.

At 8am, the boatmen come onto the island. Each day Thomas Gallagher from Ballyshannon, Reece McGrath from Pettigo and Joe Sheeran from Mountcharles arrive on the island and undertake their own work. They leave at 4pm.

Really, I can hardly remember the last time in my life I was lonely. I am at ease with my own company, he said.

As they leave the island, Father La is well into his day.

I would be hard pushed to find a time when I have been busier.

People are afraid that I am bored but Im not. The team are exceptionally busy, they have been putting so much work into alternative ways to keep in touch with pilgrims. We have set ourselves to be in outreach mode, he said.

In the evening, Father La goes up to the Basilica for night prayer.

My thoughts are to honour the rhythm of the pilgrimage season, he says.

This year, those affiliated with the island are busy in new and alternate ways.

Father La said that many people have been sending petitions to those on the island: We get a lot of people who send us petitions asking for prayer for this or that, Father La said.

In his prayers, he remains faithful to those people and the heartfelt petitions that they have undertaken to write and to send to the island.

Virtuous pilgrimage

On the last weekend in June, Father La invited people to do the full pilgrimage with him from wherever they were.

It was not a virtual pilgrimage, he said, but a virtuous one and people did fast and pray as if they were on the island.

People signed up online to participate.

Father La recalls that the pilgrimage was one where they were not blessed with favourable weather.

The rain was horizontal. It was driving rain and constant wind.

It was relentless during the night. On Saturday we got through reasonably well, he said.

Those who participated were bestowed with a certificate which carries the Lough Derg seal and are signed by the prior.

All of the certificates had to be sent out by the team to those who participated.

A pilgrimage season did not take place on the island in 1828 as result of a dispute with boatmen.

However, many more pilgrims came to the island the following year.

Pilgrimage path

There is now a newly refurbished path on the lake shore of Lough Derg.

The path which was recently relaunched would have been used by pilgrims in the medieval times.

In the 1400s pilgrims from as far away as Spain, Italy and Hungary used part of this trail as they made their way to what medieval Europe knew of as St Patricks Purgatory.

Work was being carried out on the path before the pandemic struck and six new boards were designed and ready to go when the lockdown came into effect.

There are now six display boards which bring to life the story of the Pilgrim Path and those who walk the path can enjoy stopping to read the boards.

Father La said that the full walk is around 12k along the shore road and to Saints Island.

We went to the point where pilgrims used to cross to Saints Monastery where they were given hospitality before being brought to Station Island, he said.

People can also take a shorter loop and everyone can do the walk at their own pace.

Some people like to do it in soft contemplation and reflection whilst other people like to absorb the surroundings.

Many people enjoy taking photographs in the historic and picturesque surroundings.

I led two guided groups on Saturday and Sunday, he said.

Numbers were limited as a result of the Covid-19 church and State guidelines, those who took part enjoyed it.

One-day retreat

Father La said that it remains to be seen whether a one-day retreat will take place on the island this year.

It remains to be seen whether we can open for a one-day retreat at this time, he said.

However, a meeting for the matter to be discussed will take place before the end of the week.

August 15

It is expected that Father La will remain on the island until August 15.

Enjoying his own company, reflection and prayer, Father La seems content during this years traditional pilgrimage time.

He has now become familiar with a goose who comes onto the island to graze in the grass.

The goose can be found behind St Marys, at times, and when startled will take off honking at great speeds, at times.

His presence is one that the reflective priest appreciates.

I am kind of glad for his company.

It is amazing the company that God sends you when you are on your own, he fondly says.

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Maintaining a rhythm of devout prayer and reflection at Lough Derg - Derry Now

Medical schools need to lower the cost of producing doctors – STAT – STAT

Posted on July 26, 2020 by Danzig

Medicine has become a profession accessible mainly to the rich. Just look at the price tag for medical school.

In the 1960s, the four years of medical education needed to earn an M.D. in the United States could be had for about $40,000 in todays dollars. The price is now $300,000, a 750% increase. About 70% of students take out loans to pay for medical school, graduating with an average of $200,000 in debt. One in five graduates who finance their medical education with loans accumulate more than $300,000 of debt. That average debt is increasingly concentrated in fewer people who individually owe more.

Thats not the right direction to be going in at a time when the U.S. aims to make the medical profession more inclusive. Clinician diversity improves patient care, and access to high-status professional roles in society should be available for all.

Those dollar amounts, however, reflect only the price of medical school. Reducing the price has been the focus of many efforts to put a career in medicine within broader reach. Scholarships supported by philanthropy can lower it, for example, as they have at New York University and Weill Cornell Medicine.

But as we argued recently in the New England Journal of Medicine, price is not the same thing as cost.

Trying to bring down the price of medical education tackles the issue from the wrong end. What we should really target is a reduction in the actual cost of producing a physician: the faculty time, course materials, classrooms, and administrative time. If we can lower the cost of medical education, we can lower its price and redirect the philanthropy behind those scholarships to other needed areas.

The Covid-19 pandemic is pointing to ways to do that.

Early in the pandemic, medical instruction that used to happen in physical classrooms went online. In March, medical students at the nearly 200 U.S. medical schools began learning subjects like reproductive endocrinology through Zoom or another virtual platform. Couldnt they all use the same lectures?

Undergraduate teaching across the U.S. also went online in March, but the issues arent identical. Yes, the same lectures might run across the nation, reducing costs. But the point of college is only partly about learning Shakespeare and chemistry, which can largely be delivered online, and mostly about growing up and developing independence, which requires more presence. In the first few years of medical school, the ratio is reversed: Its mostly about learning reproductive endocrinology, then later developing into an independent doctor.

In fact, many medical schools have long put online their preclinical courses, the period before students spend much time with patients. Few students even show up for the in-person sessions, viewing them on their own time and often at twice the speed, compressing an hour of lecture into 30 minutes of instruction. Why recreate that instruction 200 times each year at 200 medical schools?

Sharing lectures is just one way to lower the cost of producing doctors. Another is to shorten medical school from four years to three, as schools like NYU, Wisconsin, Duke, and others already strive toward, saving the cost of that instruction (paid by future doctors) by $160,000 to $230,000. That reflects one less year of tuition, an additional year of earning, and adding a years medical practice for the community.

The high prices of medical education and the high costs of medical education are both important. High prices have been linked to doctors avoiding lower-paying specialties, like primary care, where they may be needed most. High prices also partly explain why 73% to 79% of students entering medical school between 1988 and 2017 came from households in the top two income quintiles.

If it were less costly to produce doctors, it would be less pricey to become one. Philanthropic scholarships remain essential for a diverse workforce because its unlikely that the cost of medical education will fall low enough to eliminate its effectively exclusionary pricing. But by insulating students from the price of medical education, scholarships inadvertently insulate schools from the cost of medical education and risk perpetuating old ways.

The way we produce doctors is expensive, and we all benefit if we can do it at lower cost. The costly production of doctors is part of the reason what doctors do is so expensive. It is part of the reason a more diverse population doesnt enter medicine. It is part of the reason that philanthropy going to making medical school less pricey isnt available for making cancer care better.

And so, while we are achieving some success in lowering the price of medical education, we need to put more effort toward reducing its cost.

David A. Asch is an internist, executive director of the Center for Health Care Innovation, and professor at the Perelman School of Medicine and the Wharton School at the University of Pennsylvania. Justin Grischkan is an internal medicine resident physician at Massachusetts General Hospital and a clinical fellow in medicine at Harvard Medical School. Sean Nicholson is a professor and director of the Sloan Program in Health Administration at Cornell University.

All World football: For Owasso’s Emaud Triplett, Army and medical school are in his future, but first another 6AI title run – Tulsa World

Posted on July 26, 2020 by Danzig

OWASSO One of Emaud Tripletts heroes has always been his mother, Shelley.

The matriarch of the Triplett family served in the Navy for a decade and currently works as a nurse practitioner while pursuing her doctorate. So when the Owasso senior linebacker found an opportunity to follow in his moms footsteps in the medical field and still continue his football career, Triplett jumped at the chance.

In early June, the Rams standout announced on his Twitter page he had committed to play football at Army.

Before I had dreams of playing football, I wanted to go to medical school and be a pediatrician. I always wanted to be like my mom, Triplett said. So when the Army said they would pay for (my medical school), that just blew my mom away.

Before he heads to West Point, Triplett and fellow senior linebacker Brenden Dye hope to put a bow on their high school careers, which already include a pair of state championships. Both Triplett and Dye are candidates at linebacker in the 2020 All World Preseason Football Contest presented by Bill Knight Automotive.

The contest allows readers to vote for their favorite players at each of eight positions. Candidates were chosen on the basis of past performance, projected 2020 accomplishments and college potential. Players from all grades are eligible and may only be selected at one position.

Readers may vote once per day per device. Voting will run through 3 p.m., Aug. 13, and the winners will be announced in the Tulsa World and at OKPrepsExtra.com in late August. Go to OKPrepsExtra.com for weekly updates on who is in the lead.

Triplett led all of Class 6AI with 140 total tackles a year ago. The 5-foot-11, 210-pounder tallied eight sacks and eight tackles for loss and was a World player of the year finalist following his junior season. He is No. 1 in the Worlds preseason linebacker rankings and Dye is No. 4.

Triplett will be a three-year starter at linebacker. He also has been deployed at running back, including in last years state championship game against Jenks. Triplett scored a touchdown on a 2-yard run that helped the Rams to a 14-6 win and capped off the programs first unbeaten season.

Owasso head coach Bill Blankenship attributed some of Tripletts success at linebacker to his snaps with the offense.

Emaud benefits from having running back eyes and the experience of being a running back, Blankenship said. He sees holes, hits holes. Thats what linebackers do.

Dye will also be a three-year starter. The 6-2, 225-pounder collected 112 tackles, including seven sacks, a season ago.

In last years state semifinal win over Broken Arrow, Dye tallied 11 tackles, two sacks and a fumble recovery.

Blankenship touted his linebacker tandem as good as anybody anywhere and said both will shoulder significant loads this season after graduation losses in the secondary and a shakeup in the coaching staff.

They are, without a doubt, the heart of the defense, Blankenship said. Everything defensively starts with those two inside linebackers. Theyve got to be run stoppers and theyve got to help with the pass. They are the tone-setters for toughness. They are everything.

Vote Now: Here are the 2020 All World linebackers. You pick the best.

Owasso 5-11210Sr.

Committed to Army. The only returning All World football player of the year finalist. In 2019, led the Rams' defense with 140 tackles, including 48 solos, with eight sacks. Produced 18 tackles each against Mustang and Moore. In the regular season against Broken Arrow, had 15 tackles and a 65-yard interception return. Filled in at running back after injuries depleted that position in the playoffs and had 23 carries for 110 yards, including the Rams' second and last TD in a 14-6 win over Jenks in the 6AI state final.

Click here to vote for Emaud

Broken Arrow 6-2225Sr.

Had 95 tackles and two sacks to help the Tigers reach the 6AI semifinals last season. Recorded 16 tackles with nine solos and a key fumble recovery in a 17-15 win over Jenks. Was involved in four first-half sacks in a 35-13 win over Norman. Had five rushing TDs as a freshman for Victory Christian in 2017 before moving to Broken Arrow and helping the Tigers win a state title in a reserve role in 2018.

Click here to vote for Darryan

Metro Christian 6-1170Sr.

Shared District 2A-4 defensive player of the year honors with teammate Price Allman last year. Had 135 tackles with seven sacks and four fumble recoveries to help the Patriots post a 15-0 record and win the 2A state title. Caught a 22-yard TD pass in a playoff game against Kiefer. Had 12 tackles plus two touches for 29 yards in a season-opening win over Broken Bow. Had 87 tackles with two sacks as a sophomore in 2018.

Click here to vote for Cade

Owasso 6-2225Sr.

Had 112 tackles with seven sacks for the Rams last season. Recorded 18 tackles in a 24-10 win over Mustang. Produced 11 tackles with four for losses in a 6AI semifinal victory over Broken Arrow. Scored on a blocked punt return in the opener against Bentonville West. Had a sack or an interception in the last five games. In 2018, had 54 tackles in eight games.

Click here to vote for Brenden

Jenks 6-0190Sr.

Had 85 tackles in his first season with the Trojans helping them reach the 6AI state final. Was involved in 20 tackles against Edmond Santa Fe. The only returnee from last summer's linebacker rankings. Moved from Lincoln Christian, where he had 253 tackles over the 2017 and '18 seasons. Had 17 tackles against a 2018 3A playoff opener. In 2017, had a career-high 21 tackles against Seminole.

Click here to vote for Tyson

Stillwater 6-2220Jr.

Produced 126 tackles and three takeaways last season. Had 39 tackles in the playoffs, including nine solos in the 6AII final against Bixby. Recorded season-highs of 14 tackles against Norman and in the semifinals against Choctaw. Scored on a fumble return against Southmoore.

Click here to vote for Gabe

Bartlesville 6-2235Sr.

In 2019, had 126 tackles with seven sacks, three forced fumbles and two fumble recoveries. Was named a team captain as a junior. Has a 4.59 time in the 40. Had 87 tackles in 2018, including 16 against 6AII semifinalist Booker T. Washington and 15 against 5A semifinalist Collinsville. Also used a tight end/fullback.

Click here to vote for Braeden

Bixby 5-9200Sr.

In 2019, had 76 tackles, including 8 1/2 for losses, with three sacks and five quarterback hurries to help the undefeated Spartans win the 6AII state title. Had a season-high 11 tackles and a sack in a semifinal win over Del City. Was involved in eight tackles and had a fumble recovery against 6AI runner-up Jenks. Produced 17 tackles in a reserve role for the Spartans' 2018 state champions.

Click here to vote for Nick

Wagoner 5-8200Sr.

Led the Bulldogs defense with 143 tackles and 16 sacks. Also recovered three fumbles and had an interception. Recorded 16 tackles with a school-record six sacks in a 21-14 win at Bethany in the 4A quarterfinals. Wagoner coach Dale Condict said Gause was "dominant" and "had a breakthrough year."

Click here to vote for Trey

Lincoln Christian 5-9160Sr.

Recorded 116 tackles with three sacks to help the undefeated Bulldogs win the 3A state title last year. Had a season-high 13 tackles, including eight solos, and scored on an interception return against Stigler. Had 10 tackles with two for losses against Inola in a playoff opener. Produced 11 tackles each in the semifinals and final. Had 52 tackles in 2018.

Click here to vote for Daymon

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The 2020 All-World Preseason Football Contest presented by Bill Knight Automotive is underway, giving readers the chance throughout the summer

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All World football: For Owasso's Emaud Triplett, Army and medical school are in his future, but first another 6AI title run - Tulsa World

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