The evolution of pricing bonds and the data journey – Risk.net

Jason Waight, head of regulatory affairs, Europe at MarketAxess, considers why access to flexible data is key to using new trading protocols in fixed income

Jason Waight

Buy-side traders in the fixed income markets can have very different execution goals from one trade to the next. Price may be the key target for one investment, speed for another. The size of orders can also vary considerably, which impacts trading costs.

Help is at hand via new trading protocols and a wider variety of trading counterparties that allow firms to price bond trades in a variety of ways, according to circumstances.

All-to-all trading is not new conceptually, but is still being adopted by many firms. It is allowing non-bank traders to become price-makers, either to cut costs or even generate alpha, while still engaging in a pool of liquidity containing traditional dealers.

Internal crossing is also a valuable tool for European investors, as asset managers can find portfolios buying or selling the same assets simultaneously and exchange them at a mid-price instead of paying the spread in the market. US markets are expected to allow this model very soon, following a proposal made to the US Securities and Exchange Commission in June.

Dealers have built auto-quoting algorithms to stream prices to their clients, which can allow for rapid trading, typically in smaller-sized clips.

These different trading styles allow investment traders to find the right counterparty and trade size, at the right price. To be confident of the pricing being offered particularly where new activity extends beyond existing skill sets that trading desks had historically needed they have to be well supported by data and analytics to make the best decisions.

While bond prices are typically less volatile than equity markets, pinpointing the right price is challenging. The frequency of trading for any one instrument is far lower in bonds than in equity, creating gaps in pricing data. The number of individual instruments in bond markets is far higher and trading more fragmented as the market trades bilaterally or over the counter. These are time-limited instruments, making the proximity to issue or redemption a consideration. That makes the process of price formation more time-consuming and complex.

There are also market structural issues that make pricing less consistent. Prices for the same bond will vary depending on whether a trade is in the interdealer market or the dealer-to-client market, and the pricing of bonds for a smaller $300,000 trade will also be quite different to the pricing of a trade for a $10million block. Consequently, looking at bare numbers alone is not a good guide to pricing a trade in the future they need context.

Additionally, in 2020, price volatility for some parts of the credit space has been closer to the volatility that might be expected in equity markets, as investors look for alpha in a near-zero rate environment.

This volatility is increasing the appetite for new trading protocols but, to take advantage of them either as a price-maker or a price-taker, firms need to use pricing information that is timely, relevant and accessible. This demands sources of pricing information that capture multiple inputs and use them appropriately.

When asset managers engage with counterparties via new trading protocols, they need third-party data to benchmark the prices being offered. They can use proprietary data as well, but it is constrained because it naturally has biases based on a firms own activity rather than taking in a market-wide view of pricing. Counterparties will see a broader market of trading firms and activity and will stand their trading decisions in that context.

Where third-party pricing feeds are used, they must be transparent so they can be correctly understood and represented within analytics. The data used for one style of trading may not be appropriate for another.

For example, in all-to-all trading, firms can support price-making if they can be confident of where a bond ought to trade at a given point in time, making the timeliness of data vital, particularly if they are seeking to take advantage of volatility. That can deliver returns directly to investors.

Internal crossing removes the need for an external trading mechanism, but it must be supported by a composite price that clients can see and trust, to ensure both buyer and seller received a fair deal when the instruments were exchanged.

Having the right data sources is key to employing varied and effective trading protocols in the fixed income space. No single dataset will be sufficient given the different priorities and outcomes each is seeking to achieve. Access to data should reach across functions, so anyone within trading, portfolio management or risk who is needed to support a decision can do so in a timely fashion. MarketAxess Axess All platform the closest it has to an intraday tape in Europe has seen a growth in use beyond the trading desk to support a single view of the market and better management of trading as a part of the larger investment picture.

Data must also be accessible to support post-trade activity for each of these trading models. Whether using transaction cost analysis or other execution quality analysis, traders will need to benchmark execution against several measures, including the prices offered across several possible execution choices, and this hinges on the right data being available.

Improving execution quality over time is only viable if traders can use independent data to check the prices they are provided, and to frame that within similar market activity at that point. That information should include information that will help to contextualise implicit costs.

These costs might include that of not filling an order or of the market impact that a trade incurs, as well as explicit costs such as the fees charged by a trading platform and the spread at that point in time. Through quantitative analysis of execution quality across different trading protocols, buy-side firms have been able to exert pressure on their sell-side liquidity providers to provide better quotes.

During the height of market volatility in March, buy-side participation in all-to-all trading on MarketAxess Open Trading protocol nearly doubled. Firms that have begun to use this and other protocols for the first time are becoming more flexible in managing market risk and returns. Flexible access to data must develop in parallel to support this evolution.

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The evolution of pricing bonds and the data journey - Risk.net

Global Home Healthcare Equipment Market Predicted to Witness Sustainable Evolution in Years to Come by : Lifescan, Medtronic, A&D Company, Limited,…

Global Home Healthcare Equipment Market presents comprehensive insights into the present and upcoming industry trends, enabling the readers to identify the products and services, hence driving the revenue increase and effectiveness. The research report presents a complete breakdown of all the major factors affecting the market on a global and regional scale, including drivers, constraints, threats, challenges, opportunities, and Home Healthcare Equipment industry-specific trends. Further, the report mentions global facts and figures along with downstream and upstream analysis of leading players.

The study gives answers to the following key questions:

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Major Players:

LifescanMedtronicA&D Company, LimitedAbbott LaboratoriesOmron CorporationRochePanasonicYuwellSANNUOOSIMSiemensInsuletAnimasMicrolifePhonakWilliam DemantInvacare

This research presents Home Healthcare Equipment market growth rates and the market value based on market dynamics, growth factors. The complete knowledge is based on the newest innovation in the business, opportunities, and trends. In adding up to SWOT analysis by key suppliers, the report contains an all-inclusive market analysis and major players landscape.

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The regional segmentation covers:

Segmentation by Type:

Blood Glucose MonitorBlood Pressure MonitorRehabilitation equipmentOthers

Segmentation by Application:

Diagnostics and MonitoringTherapeuticsCare and RehabilitationOthers

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Global Home Healthcare Equipment Market Size, Status and Forecast 2020-2024

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Global Home Healthcare Equipment Market Predicted to Witness Sustainable Evolution in Years to Come by : Lifescan, Medtronic, A&D Company, Limited,...

Gamification Market Predicted to Witness Sustainable Evolution in Years to Come | Cognizant Technology Solution, MPS Interactive Systems, Microsoft -…

Keep yourself up-to-date with latest market trends and maintain a competitive edge by sizing up with available business opportunity in Global Gamification Market various segments and emerging territory. The research report presents a comprehensive assessment of the Global Gamification Market and contains thoughtful insights, facts, historical data, and statistically supported and industry validated market data. It also contains projections using a suitable set of assumptions and methodologies. The research report provides analysis and information according to categories such as market segments, geographies, type of product and competition landscapes.

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What is Global Gamification?Gamification refers to the utilization of game design principles to enhance customer engagement in non-game businesses. The particular strategies used range from the creation of reward schedules to creating levels of accomplishment via status and badges. Companies use gaming principles to extend interest in a product or service, or simply to deepen their customers relationship with the brand. Based on the platform, the market has been segmented into an open platform and closed/ enterprise platform.

Market Drivers

Market Trend

Restraints

Opportunities

Challenges

Important Features that are under offering & key highlights of the Global Gamification market report:

> The study is conducted by collecting data of various companies from the industry, and the base for coverage is NAICS standards. However, the study is not limited to profile only few companies. Currently the research report is listed with players like Cognizant Technology Solution Corp. (India), MPS Interactive Systems Limited (India), Microsoft Corporation (United States), Callidus Software Inc. (United States), Cut-e GmbH (AON, PLC) (Germany), Axonify Inc. (Canada), IActionable Inc. (United States), Bunchball Inc. (United States), SAP SE (Germany) and Salesforce.com, Inc. (United States). According to Market Analyst at AMA, the Global Gamification market may see a growth rate of 31.2%

> In the premium version of report, two-level of regional segmentation allows user to have access to country level break-up of market Size by revenue and volume* Additionally it also highlights how local reforms have made impact in the country and how business segments are performing or may perform in future.

* Wherever applicable

> Yes, for a deep dive we do provide add-on segmentation in premium version of report to better derive market values. The standard version of this report covers segmentation by Application, by Type and by Regions and players

The Global Gamificationsegments and Market Data Break Down are illuminated below:Application (Retail, Banking, Government, Healthcare, Education and Research, IT and Telecom, Others), Enterprise Size (Small and Medium Enterprises, Large Enterprises), Platform (Open Platform, Closed/ Enterprise Platform), Deployment (On-premise, On-cloud)

Analytical Market Highlights & Approach:The Global Gamification Market report provides the rigorously studied and evaluated data of the top industry players and their scope in the market by means of several analytical tools. The analytical tools such as Porters five forces analysis, feasibility study, SWOT analysis, and ROI analysis have been practiced reviewing the growth&operational efficiency of the key players operating in the market.

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What benefits does AMA research studies provides:

On the basis of geographical regions, the Global GamificationMarket is segmented broadly into Latin America, Europe, the Middle East and Africa, and Asia Pacific. The global market is still in its exploratory stage in most of the regions but it holds the promising potential to flourish steadily in coming years. The major companies investing in this market are situated in Canada, U.K., and the US, India, China and some more countries of Asia Pacific region. Consequently, Asia Pacific, North America, and Western Europe are estimated to hold more than half of the market shares, collectively in coming years.

Table of ContentGlobal Global Gamification Market Research Report

Chapter 1:Global Gamification Market Overview

Chapter 2: Global Economic Impact on Industry (COVID Impact Analysis, Local Reformsetc)

Chapter 3: Global Market Competition by Manufacturers

Chapter 4: Global Revenue (Value) , Supplies (Production), Consumption, Export, Import by Regions (2014-2025)

Chapter 5: Global Revenue (Value), volume, Price Trend by Type (2014-2025)

Chapter 7: Global Market Analysis by Application (2014-2025)

Chapter 8: Manufacturing Cost Analysis, Benchmarking (2019)

Chapter 9: Industrial Chain, Sourcing Strategy and Downstream Buyers

.

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Key questions answered

Definitively, this report will give you an unmistakable perspective on every single reality of the market without a need to allude to some other research report or an information source. Our report will give all of you the realities about the past, present, and eventual fate of the concerned Market.

Thanks for reading this article, we can also provide customized report as per companys specific needs. You can also get separate chapter wise or region wise report versions including North America, Middle East & North Africa (MENA), Europe or Southeast Asia, Asia-Pacific.

About Author:Advance Market Analytics is Global leaders of Market Research Industry provides the quantified B2B research to Fortune 500 companies on high growth emerging opportunities which will impact more than 80% of worldwide companies revenues.Our Analyst is tracking high growth study with detailed statistical and in-depth analysis of market trends & dynamics that provide a complete overview of the industry. We follow an extensive research methodology coupled with critical insights related industry factors and market forces to generate the best value for our clients. We Provides reliable primary and secondary data sources, our analysts and consultants derive informative and usable data suited for our clients business needs. The research study enable clients to meet varied market objectives a from global footprint expansion to supply chain optimization and from competitor profiling to M&As.

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Gamification Market Predicted to Witness Sustainable Evolution in Years to Come | Cognizant Technology Solution, MPS Interactive Systems, Microsoft -...

Global Industrial PC Market Predicted to Witness Sustainable Evolution in Years to Come by : Advantech, Adlinktech, Siemens, EVOC, Norco, Contec,…

Global Industrial PC Market presents comprehensive insights into the present and upcoming industry trends, enabling the readers to identify the products and services, hence driving the revenue increase and effectiveness. The research report presents a complete breakdown of all the major factors affecting the market on a global and regional scale, including drivers, constraints, threats, challenges, opportunities, and Industrial PC industry-specific trends. Further, the report mentions global facts and figures along with downstream and upstream analysis of leading players.

The study gives answers to the following key questions:

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Major Players:

AdvantechAdlinktechSiemensEVOCNorcoContecAnovoAAEONAxiomtekB&R Automation

This research presents Industrial PC market growth rates and the market value based on market dynamics, growth factors. The complete knowledge is based on the newest innovation in the business, opportunities, and trends. In adding up to SWOT analysis by key suppliers, the report contains an all-inclusive market analysis and major players landscape.

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The regional segmentation covers:

Segmentation by Type:

Panel IPCRackmount IPCBox IPCOther

Segmentation by Application:

Energy & PowerOil & GasChemicalPharmaceuticalAutomotiveAerospace & DefenseOther

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Report Objectives

Global Industrial PC Market Size, Status and Forecast 2020-2024

Browse Detailed TOC & Table Of Figures

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Global Industrial PC Market Predicted to Witness Sustainable Evolution in Years to Come by : Advantech, Adlinktech, Siemens, EVOC, Norco, Contec,...

Tale of an intersection written in change: State and Union undergoes evolution – Traverse City Record Eagle

TRAVERSE CITY Traverse Citys new civic gathering space, Rotary Square, will bring big changes to the southeast corner of State and Union streets.

Big changes are nothing new to this intersection.

Over the last 150 years this area has been home to a lumberyard, a wagon works factory, gas stations, an early version of a farmers market, and numerous commercial enterprises.

Long before white settlement, local Anishinaabek regularly came to West Bay to pick berries and fish.

A trail marker on the southwest corner of Lake Avenue and Cass Streets commemorates one of the trails that crisscrossed this region. It is highly likely that tribal members moved along the banks of the Boardman River, very near the soon-to-be-built Rotary Square.

When white settlers first arrived in northern Michigan in the mid-1800s, agriculture dominated the American economy. But by the 1870s the American Industrial Revolution was well under way.

This mix of agriculture and industry was reflected in the earliest businesses arising around State and Union.With lumbering considered sometimes agricultural, and sometimes industrial, a Hannah & Lay Co. lumberyard on the northeast corner of the intersection was the perfect example of this mix.

In 1890 the corner section of the lumberyard was replaced by a saloon, although its safe to assume that a sizeable portion of the saloons customers still worked in the lumber industry.

The lumberyard was not this areas only hint of agriculture.

As late as 1919 the northwest corner housed a small clapboard building, almost a shack, where farmers would exchange crops. Perhaps it could be thought of as an early, low-key Sarah Hardy Farmers Market.

In the 1890s, just to the north of the exchanges location, stood a blacksmiths shop. And for the first couple of decades of the 20th century the southwest corner of the intersection was the location of A.J. Petertyls Traverse City Wagon Works.

By the 1920s both of these small industrial operations, as well as many of the larger industrial enterprises along West Bay and Boardman Lake, were closing down. Industry was waning. Broader commercial activities, and even tourism, began driving Traverse Citys economy.

For tourists and townspeople alike, the internal combustion engine was overtaking the horse as Americas main mode of transportation. All of this was reflected in the developments at State and Union.

By 1929 businesses on three of the intersections four corners catered to the automobile. Filling stations sat on the northwest and southeast corners. On the southwest corner the wagon works had been replaced by an auto repair shop, although the current U.S. Post Office opened at that location in 1939.

Those catty-cornered gas stations, operating under several different owners, remained in business to the turn of the 21st century.

The Rennie Oil Company occupied the northwest corner from 19401970, and was replaced by Kinneys Pioneer Service, which ran until 2007. The corner is now filled with a three-story mixed-use commercial and residential building.

Long-time resident Larry Hains recalls both the Rennie Oil Company and Kinneys Pioneer Service displaying a kind of three-dimensional public service announcement.

I remember for years the stations had the practice of placing vehicles from extremely bad wrecks right on the corner, easily seen by all. They were a warning to drive carefully, said Hains.

Across Union Street the saloon on the northeast corner at some point closed, and in the 1940s the building was occupied by The James Electric and Appliance Company. Esthers Beauty Shop served customers in that space from 1950 1979, and Strong, Drury and Elkins Architects occupied it from 19791993. Since 1993 the site has hosted Cousin Jennys Cornish Pasties.

Esther Sprague ran Esthers Beauty Shop. Memories paint a picture of a place where people felt welcomed and at ease.

Esther was a wonderful person to work for. She was so generous with all of us ladies that worked there, recalled Millie Acre Salensky.

Barbara Smith recounts a summer family tradition from the late 1950s and early 1960s: As soon as school was out, her mother would take her and her two sisters to Esthers for summer haircuts.

For years they would receive very short pixie cuts. Smith is pretty sure that was their only hair cut each year, after which they would let it grow out until the next summer.

I met my future wife there, but not while getting a pixie haircut! says Douglas Salensky.

What of the southeast corner itself? The first known building on that corner was the State Street School, which was moved there in 1877.

The school was originally built in 1869 facing Park Street, at a time when it still ran south of State Street all the way to the bank of the Boardman River. The school sat at approximately the location of todays Park Place Hotel annex.

It was an addition to the 1856 White School, named for its paint job, which was the first building built as a school within the city limits.

In the 1880s a string of four more buildings were constructed facing Union Street to the south of the State Street School. The various businesses housed in these buildings reflected Traverse Citys continuing development as a commercial hub.

Those businesses included several restaurants, grocers, a dress shop, a barber, a tailor, a crockery and furniture store, a bicycle shop, a sewing machine shop, a pawn broker, and, eventually, the gas stations that sat catty-corner from Rennies and Kinneys.

The gas station on that southeast corner belonged to Jess Letherby in the late 1930s, and by the 1960s was owned by Curley Crandall. By 1998 the building had been remodeled to house NPI Wireless and Noverr Publishing, then Northwestern Bank, and most recently, Chemical Bank.

Another big change soon will be coming to the intersection of State and Union. Over more than a century and half, Traverse City has successfully adapted to the times. Through agricultural, industrial, commercial, and tourist economies, this town continues to be the thriving little city that could.

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Tale of an intersection written in change: State and Union undergoes evolution - Traverse City Record Eagle

WW3 warning: Russia and China investing in submarines to target US – Daily Express

The chilling claims were made by Lt Gen Glen VanHerck as he testified before the Senate Armed Services Committee as part of his confirmation process to be the Commander of US Northern Command. Lt Gen VanHerck currently serves as director of the Joint Staff in the Pentagon.

He told the hearing on Tuesday that he expects a "full challenge" from America's adversaries if he is approved for the top level position.

At at the front of the pack, he said, would be Russia and China.

He discussed how the US has found itself in a new situation as both Moscow and Beijing work to find ways to challenge America's global military dominance.

Lt Gen VanHerck said the national security challenge faced by the US today is more serious than it has been in more than three decades.

He also said America's foes, particularly China and Russia had been closely "watching" the US to plan their next moves.

He told senators: "Over 32 years of service, I don't think I've ever seen as strategic and dynamic a national security challenge as we have today.

"Over the last three decades, our competitors and potential adversaries have watched the United States and our way of deterring and our way of competing and our way of conflict.

"They have taken the opportunity to adapt to that environment by watching us, specifically China and Russia, across all domains."

READ MORE:Trump vs Putin: US President sends dire warning to Russia

He went on to single out Russia, which he says boasts sophisticated submarines which can carry weapons capable of hitting the US

He added: "Russia develops strategic capabilities, such as their submarines, which now are a significant challenge for tracking and pose the potential for cruise missiles that can strike the homeland."

And he warned that China would follow the Russians down the same route.

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He said the Chinese "will do the same" as the Russians "in the not so distant future as they continue to develop their capabilities and become more expeditionary."

His warning comes days after Russia's strongman president said the Russian Navy would be armed with hypersonic nuclear strike weapons and underwater nuclear drones, which the defence ministry said were in their final phase of testing.

President Putin, who says he does not want an arms race, has often spoken of a new generation of Russian nuclear weapons that he says are unequalled and can hit almost anywhere in the world.

Some Western experts have questioned how advanced they are.

The weapons, some of which have yet to be deployed, include the Poseidon underwater nuclear drone, designed to be carried by submarines, and the Tsirkon (Zircon) hypersonic cruise missile, which can be deployed on surface ships.

Meanwhile China has also been busy investing in new defence systems and earlier this year showcased two new submarines.

The vessels are capable of carrying nuclear-tipped ballistic missiles.

The country's navy deployed the latest additions back in April.

The subs shore up the third leg of China's nuclear triad - which is based on air, land and sea defence systems.

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WW3 warning: Russia and China investing in submarines to target US - Daily Express

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What Is Brexit? And What Happens Next? – The New York Times

Mary Turner for The New York Times

After three years of haggling in the British Parliament, convulsions at the top of the government and pleas for Brussels to delay its exit, Britain closes the book on nearly half a century of close ties with Europe on Jan. 31.

Its split with the European Union was sealed when Prime Minister Boris Johnsons Conservative Party won a resounding victory in Decembers general election. That supplied Mr. Johnson with the parliamentary majority he needed to pass legislation in early January setting the terms of Britains departure, a goal that repeatedly eluded his predecessor, Theresa May. European lawmakers gave the plan their blessing later in the month.

Mr. Johnson, a brash proponent of withdrawal, will now guide the country through the most critical stage of Brexit: trade negotiations that will determine how closely linked Britain remains with the bloc.

Little will change overnight. At midnight in Brussels on Jan. 31 11 p.m. in London, a reminder that the European Union sets the terms of departure Britain will begin an 11-month transition in which it continues to abide by the blocs rules and regulations while deciding what sort of Brexit to pursue.

What ultimately emerges as Britain parts ways with the European Union could determine the shape of the nation and its place in the world for decades. What follows is a basic guide to Brexit: what it is, how it turned into a political mess and how it may ultimately be resolved.

Lets start with the basics

A portmanteau of the words Britain and exit, Brexit caught on as shorthand for the proposal that Britain split from the European Union and change its relationship to the bloc on trade, security and migration.

Britain has been debating the pros and cons of membership in a European community of nations almost from the moment the idea was broached. It held its first referendum on membership in what was then called the European Economic Community in 1975, less than three years after it joined. At the time, 67 percent of voters supported staying in the bloc.

But that was hardly the end of the debate.

In 2013, Prime Minister David Cameron promised a national referendum on European Union membership with the idea of settling the question once and for all. The options offered to voters were broad and vague Remain or Leave and Mr. Cameron was convinced that Remain would win handily.

That turned out to be a serious miscalculation.

As Britons went to the polls on June 23, 2016, a refugee crisis had made migration a subject of political rage across Europe. Meanwhile, the Leave campaign was hit with accusations that it had relied on lies and that it had broken election laws.

In the end, a withdrawal from the bloc, however ill-defined, emerged with the support of 52 percent of voters.

Brexit advocates had saved for another day the tangled question of what should come next. Even now that Britain has settled the terms of its departure, it remains unclear what sort of relationship with the European Union it wants for the future, a matter that could prove just as divisive as the debate over withdrawal.

How did the referendum vote break down?

Most voters in England and Wales supported Brexit, particularly in rural areas and smaller cities. That overcame majority support for remaining in the European Union among voters in London, Scotland and Northern Ireland. See a detailed map of the vote.

Young people overwhelmingly voted against leaving, while older voters supported it.

Why is it such a big deal?

Europe is Britains most important export market and its biggest source of foreign investment, while membership in the bloc has helped London cement its position as a global financial center.

With some regularity, major businesses have announced that they are leaving Britain because of Brexit, or have at least threatened to do so. The list of companies thinking about relocating includes Airbus, which employs 14,000 people and supports more than 100,000 other jobs.

The government has projected that in 15 years, the countrys economy would be 4 percent to 9 percent smaller if Britain left the European Union than if it remained, depending on how it leaves.

Mrs. May had promised that Brexit would mean an end to free movement that is, the right of people from elsewhere in Europe to live and work in Britain. Working-class people who see immigration as a threat to their jobs viewed that as a triumph. But an end to free movement would cut both ways, and the prospect was dispiriting for young Britons hoping to study or work abroad.

How did we end up with a Jan. 31 deadline?

Before Parliament approved Mr. Johnsons withdrawal agreement in January, just about the only clear decision it made on Brexit was to give formal notice in 2017 to quit, under Article 50 of the European Unions Lisbon Treaty, a legal process setting it on a two-year path to departure. That made March 29, 2019, the formal divorce date.

But departure was delayed when it became clear that hard-line pro-Brexit Conservative lawmakers would not accept Mrs. Mays withdrawal deal, which they said would trap Britain in the European market.

The European Union agreed to push the date back to April 12. But the new deadline did not bring about any more agreement in London, and Mrs. May was forced to plead yet again for more time. This time, European leaders insisted on a longer delay, and set Oct. 31 as the date.

Mr. Johnson took office in July, and vowed to take Britain out of the bloc by that deadline, with or without a deal. But opposition lawmakers and rebels in his own party seized control of the Brexit process, and moved to block a no-deal withdrawal, which would have meant Britain leaving without being able to cushion the blow of a sudden divorce.

That forced Mr. Johnson to seek an extension, something he had said he would rather be dead in a ditch than do. European leaders agreed to extend the deadline by three months, to Jan. 31, as Britain considered its options.

Ultimately, Mr. Johnson persuaded enough opposition lawmakers to agree to an early general election. His Conservative Party won an 80-seat majority, the largest since Margaret Thatcher in 1987.

What happens next?

Much as Jan. 31 marks a symbolic milestone, it is merely the beginning of a potentially more volatile chapter of the turbulent divorce, in which political and business leaders jockey over what sort of Brexit will come to pass.

Every path holds risks for Mr. Johnson, all the more so after an election in which he was buoyed by voters in ex-Labour heartland seats in northern and central England who stand to suffer from trading barriers with Europe.

And the clock is ticking: The end of the transition period is Dec. 31. Any request to extend that deadline would have to be made by June.

Mr. Johnson, though, has repeatedly vowed to complete the departure by the end of the year. If he sticks to his word, Britain and the European Union will have to strike a deal governing future trade across the English Channel at an unusually fast pace. (It took seven years, for example, for the European Union and Canada to negotiate their 2016 trade deal.)

That will involve negotiations over trade in manufactured goods as well as services, which make up the bulk of the British economy. Should the two sides fail to reach an agreement, even a narrow one that leaves some issues for next year, Britain would crash out of the bloc with no deal at all, raising the prospect of tariffs and border disruption that would mirror the sort of no-deal Brexit that lawmakers have long feared.

Among the points of contention will be Mr. Johnsons wish to break from European standards on labor, the environment and product safety. The more space Britain puts between its rules and Europes, the blocs leaders have said, the more they will hamper Britains access to the European market. Any restrictions of that sort would threaten British jobs, reliant as many of them are on European customers.

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What Is Brexit? And What Happens Next? - The New York Times

Pro-Brexit and right-wing academics ‘forced to censor views’ for fear of being shunned – Daily Express

Academics who identify their political views as right-wing are much more likely to conceal their views from their employers. This was intensified among Brexit supporters, with many fearing expressing such views would have a negative impact on their careers.

The report titled Academic Freedom in the UK, by the Policy Exchange think tank, found university campuses are increasingly governed by unwritten rules, which encourage academics to hide unfashionable opinions.

It found that right-wing and pro-Brexit academics were most likely to censor their political views, in fear of being ostracised or passed over for promotion.

The authors described this as having a chilling effect on academic research and teaching.

A YouGov poll of 820 academics, carried out on March 27 2020, found that almost one third of respondents (32 percent) of those who say their political views are right or fairly right have stopped openly airing opinions in teaching and research.

This was compared with 13 percent of those in the centre and on the left.

When it came to views on Brexit, 27 percent of pro-Leavers said they had refrained from publishing or airing views for fear of consequences to their career.

This compares with 11 percent of Remain supporters.

The report also found there is widespread support for discrimination on political grounds in publication, hiring and promotion - especially when it came to views on Brexit.

JUST IN:POLL: Should Boris walk away now or enter into autumn talks with EU?

It found that only 54 percent of academics said they would feel comparable sitting next to a known Leave supporter at lunch, while 86 percent said they would be happy to sit next to a Remainer.

Furthermore, a third of academics said they would avoid hiring a known Leave supporter.

The researchers also estimated that between a third and a half of those reviewing a grant bid would mark it lower if it took a right-wing perspective.

The report said: It is likely that academics do not discriminate more than other professions, nor does left discriminate more than right.

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The evidence, however, is that due to the small number of academics who identify as on the right, there is a structural discriminatory effect against them.

Hostile or just uncomfortable attitudes signal to those subject to such discrimination that they should conceal their views and narrow their research questions to conform to prevailing norms, if they wish to progress and enjoy a positive workplace experience.

The 123-page report pointed out that UK-based academics are now significantly more left-leaning than before, with fewer than 20 percent voting for right-leaning parties, and about 75 percent voting for Labour, the Lib Dems or the Green parties in the 2017 and 2019 general elections.

As a result, the smaller proportion of Tories in academia results in a much larger discriminatory effect against them, the report claimed.

The report was written by Remi Adekoya, who teaches politics at Sheffield University, Eric Kaufmann, professor of politics at Birkbeck College, and Tom Simpson, associate professor of philosophy at Oxford and published on Monday.

The authors call for Parliament to create a director for academic freedom with ombudsman powers.

The sample of 820 academics interviewed for the study consisted of 484 currently employed and 336 retired.

It also urges MPs to put forward an Academic Freedom Bill to ensure that universities support intellectual dissent and allow for all lawful speed to be protected on campus.

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Pro-Brexit and right-wing academics 'forced to censor views' for fear of being shunned - Daily Express

DUPs Brexit ads: Who bankrolled the secretive 435,000 campaign? – The Irish Times

Longford-born journalist Peter Geoghegan was sitting in a train carriage in Newcastle just before the Brexit referendum in 2016 when a quest began to unravel a mystery about the Democratic Unionist Partys role in winning it.

Flicking through a well-thumbed copy of the Metro newspaper, Geoghegan, who works now in Glasgow and London, saw the free newspapers front page wraparound advertisement.

In it, British voters were urged to Take back control, the slogan of the official Vote Leave campaign, Geoghegan recalls in his new book, Democracy for Sale, which is published by Head of Zeus on Thursday.

I turned the paper over. An imprint on the back said that the advert had been paid for by the Democratic Unionist Party, says Geoghegan, a journalist with opendemocracy.net.

This was very curious. Since its foundation in 1971, the Democratic Unionist Party had never run a single candidate outside Northern Ireland, he writes.

It was a little epiphany that ultimately led him down a number of other tracks and has resulted in the book.

It is filled with the likes Steve Bannon, Donald Trump, Dominic Cummings, Boris Johnson, Nigel Farage and a former head of Saudi Arabian intelligence, Prince Nawwaf bin Abdul Aziz al Saud.

Right there, too, is the DUP, which spent 435,000 on a massive ad campaign promoting Brexit in England. I knew that election spending in the UK is tightly capped.

I also knew, having worked as a reporter in Belfast, that political donations to Northern Irish parties were kept secret under anachronistic local laws. Perhaps this was a way around campaign limits?

So, would he solve the mystery?

In his sleuthing Geoghegan examines how the DUP was bankrolled by the biggest [political] donation in Northern Irish history to support the campaign to take the UK out of the European Union.

Geoghegan contends in Democracy for Sale that the money was channelled to the DUP through the official Vote Leave campaign because Vote Leave had almost used up its permitted spending of 7 million.

Vote Leave and the DUP have denied the claim.

Other organisations on both sides of the campaign were allowed additional spending of up to 700,000. The author recounts how he discovered that an uncommunicative organisation called the Constitutional Research Council (CRC) donated 435,000 to the DUP to support the Leave crusade.

To prop up his Vote Leave-DUP connection conviction, Geoghegan writes, Two months before the referendum, Matthew Elliott, Vote Leaves chief executive, wrote in an email to senior staff: The DUP also have a 700k spending limit, which can be spent nationwide!

At that stage the DUP had yet to register as a referendum participant, Geoghegan writes. It only did so in late May. When the CRC started giving money to the DUP, Vote Leave had almost completely exhausted its spending allowance.

Geoghegan writes how the DUPs Brexit spending spree began on June 9th, exactly two weeks before the vote, when the DUP bought 100,000 worth of placards, bags, window stickers, T-shirts and badges from a small branding agency called Soopa Doopa.

This company was based in the Cambridgeshire cathedral town of Ely. The location and the company was a surprising choice for the DUP, thought Geoghegan. The fact that it published more than 800,000 of material for various Leave-supporting groups reinforced his belief that this was part of the alleged Vote Leave-DUP nexus.

Two days before polls opened, Geoghegan writes, the CRC donated a further 334,993 to the DUP, much of which was spent on the wraparound ad in the Metro a paper that does not circulate in Northern Ireland.

He also says the DUP spent 32,000 on digital advertising through a Canadian company called AggregateIQ (AIQ) which had bought millions of pounds worth of Facebook ads on behalf of a suite of pro-Brexit campaigns clustered around Vote Leave.

The Westminster fake news inquiry that began in 2017 and concluded in 2019 heard that AIQ had links with Cambridge Analytica, the political consulting firm founded by US billionaire Robert Mercer and US president Donald Trumps former chief strategist Steve Bannon, although this has been denied by AIQ co-founder Zack Massingham.

Cambridge Analytica got in serious trouble over allegedly misappropriating digital information, including acquiring the personal data of tens of millions of Facebook users.

Geoghegan, following the money trail, writes that according to Cambridge Analytica whistleblower Chris Wylie, the DUP were simply a front organisation to allow Vote Leave to go beyond spending limits imposed by election laws again a charge that Vote Leave and the DUP strongly deny.

Geoghegan explores how the only publicly known person associated with the CRC the group that gave the 435,000 to the DUP is Scottish businessman Richard Cook, a Conservative Party activist and Glasgow Rangers supporter.

He is depicted as a colourful figure, who in 2013 jointly founded a company called Five Star Investments with Prince Nawwaf bin Abdul Aziz al Saud, a former director general of the Saudi intelligence agency who died in 2015. Cook held 5 per cent of the shares, the prince 75 per cent, and a third man, Danish national Peter Haestrup, held the other 20 per cent.

Haestrup was allegedly linked to an Indian gun-running case known as the Purulia Arms Drop. Haestrup told Geoghegan he was never charged, had a 100 per cent clean record and had done nothing wrong. He also explained how the wealth management business did not get off the ground and was dissolved in 2014 after a lot of good dinners.

Despite these intriguing connections, Geoghegan portrays Cook as a man who would not have 435,000 to easily hand over to the DUP. He is convinced the CRC money came from other sources. Former Scottish Labour leader Jim Murphy told Geoghegan that Cook, his long-time political adversary in East Renfrewshire, was a bizarrely unlikely middle-man for this sort of money.

In addition to the 435,000, the author writes about how the CRC made two further contributions to the DUP after the Brexit referendum, totalling more than 13,000 the DUP very generally and impenetrably saying it had used the money to further the cause of unionism at home and abroad.

Geoghegan writes that Cook refused to reveal the source of the cash and said that, although he had administered the massive DUP donation, he had never received any money from his involvement in the CRC. I just run a small consultancy company, doing some waste energy stuff internationally, he said.

Geoghegan does a lot of mining to find the other CRC backers but, as he admits, the gold seam proves elusive, his work not helped by electoral law in Northern Ireland or the DUPs refusal to answer questions.

Under previous electoral legislation in the North, political donors during the Troubles did not have to disclose their names or the size of their contributions because doing so could endanger their lives.

In July 2017 that changed when then northern secretary James Brokenshire decided that life had moved on and donation details could be published.

It could have been the moment that changed everything. However, it was not to be. Brokenshire could have backdated that legislation to January 2014, but decided not to.

This led to allegations that he had done a side deal with the DUP a charge bolstered by the fact that this was at a time when the DUP had signed up to a 1.5 billion confidence and supply deal to keep then UK prime minister Theresa Mays Tory government in power.

It prompted former head of the Norths Electoral Commission Seamus Magee to deduce: The deal on party donations and loans must be part of the DUP/Conservative deal. No other explanation.

This was denied at the time by DUP MP Jeffrey Donaldson.

Geoghegan, still chasing, writes how, in mid December 2017, 17 MPs met in a Westminster committee room to consider a legal order that would bring donor transparency to Northern Ireland.

During a truncated and bad-tempered debate, DUP MPs Sammy Wilson and Ian Paisley, who were observers, insisted that their party had been wholly transparent about the 435,000 donation.

Saying that the failure to backdate the legislation stinks, Labour MP Ben Bradshaw added: The only conclusion that any reasonable person can draw is that the DUP was used, with its knowledge, by the CRC to funnel money to the Leave campaign in a way that to this day keeps the source of that money secret. By refusing to make this provision retrospective, the government are effectively complicit in covering that up.

In his book Geoghegan addresses many fascinating issues in relation to dark money, Brexit and political funding but in the end admits his investigation into the DUP and CRC does did not answer the big question.

The wall of silence could not be penetrated. He concedes, Just how much control the DUP had over its record donation and how it was spent remains unclear. And who was behind the money is still a mystery.

View original post here:

DUPs Brexit ads: Who bankrolled the secretive 435,000 campaign? - The Irish Times

Brexit hit looms for industries that escaped worst of pandemic – The London School of Economics and Political Science

Businesses that have escaped the worst effects of the economic fallout from the COVID-19 pandemic are typically in sectors which are more likely to feel the impacts of Brexit, a new analysis finds.

The reportCOVID-19 and Brexit:Real-time updates on business performance in the United Kingdomwas published today (29 July 2020) by the LSEs Centre for Economic Performance (CEP). It shows that sectors which entail more human contact such as airlines, restaurants, hotels and arts and entertainment have been hardest hitby the pandemic.

Meanwhile, those sectors that rely more on business-to-business demand, and which can be delivered virtually, have been less hard hit. These include ICT services and professional, technical and scientific industries such as accounting, legal activities and scientific research.

Report authors, Josh De Lyon and Dr Swati Dhingra,alsoshow that sectors affected by Brexit are generally different to those currently impacted by COVID-19. When comparing the effect of COVID-19 with the predicted impact of increased trade barriers with the EU, there is some evidence that those lesshitby COVID-19 are likely tosuffer more fromBrexit. Electrical and Optical Equipment and Chemicals and Chemical Products are examples of such sectors.

A closer look shows the experiences of industries differs a lot. While businesses such as hotels and restaurants have been hit hard by COVID-19, they are predicted to see little change from trade rules with the EU. Other sectors, however, such as Inland Transport have been impacted by the pandemic and are also expected to be significantly affected by a no-deal Brexit, thus experiencing a double hit.

The analysis uses data from the real-time business survey of member and non-member firms collected by the Confederation of British Industry (CBI). This shows how business performance and expectations have varied in April, May and June 2020.

It reveals:

Josh De Lyon, research assistant at CEP, said:As the impacts of COVID-19 on different types of business become clearer, the government must move beyond its broad assessment of Brexit impacts to much more finely tuned plans that account for the differences in market conditions and constraints faced by UK businesses in the biggest slowdown of our lifetime.

Dr Swati Dhingra, CEP associate and Associate Professor in Economics at LSE, said:The large negative hit from the pandemic has reduced the capacity of the UK economy to take further shocks. The UK is highly integrated with Europe and these links are likely to be even more important throughout the pandemic. The slowdown of the world economy has also cast another shadow on the idea of a Global Britain unlocking a higher trade potential outside of the EU.

Our analysis shows that the sectors that will be affected by Brexit and those that are suffering from the COVID-19 pandemic and lockdown are generally different from each other. Rushing Brexit through this year without a new deal in place would therefore broaden the set of sectors that see worsening business conditions.

The report concludes that government policies to stimulate demand, support workers to remain in employment or find new employment, and to support businesses remain essential.

The full report can be read here:COVID-19 and Brexit: Real-time updates on business performance in the United Kingdom

See the article here:

Brexit hit looms for industries that escaped worst of pandemic - The London School of Economics and Political Science

Government says medicines must be stockpiled for no-deal Brexit on top of Covid-19 pressures – The Independent

The government has written to to medicine suppliers urging them to stockpile drugs for a possible no-deal in EU trade talks at the end of the year after firms warned that this may not be possible because of the pandemic.

In a letter made public on Monday officials at the health department said the government recognises "that global supply chains are under significant pressure" because of coronavirus, but said the expensive precaution was still necessary.

In June a pharmaceutical industry memo said original stockpiles meant for no-deal had been used up entirely and that it might not be possible to replenish them before December, when the UK is due to leave the single market.

Sharing the full story, not just the headlines

Boris Johnson refused to extend the Brexit transition period last month despite disruption caused by coronavirus and the fact the UK is facing a cliff-edge at the end of the year.

Flagging trade talks mean it is increasingly likely that Britain will leave the single market without any trade agreement at all, with disruption to trade and supply chains expected.

"Holding additional stock in the UK provides a further buffer against some disruption and we believe, where its possible, its a valuable part of a robust contingency plan," the letter, signed by Steve Oldfield, chief commercial officer at the Department of Health and Social Cares says.

"To build upon past work and ensure a co-ordinated approach, we will be asking suppliers to confirm their contingency plans for the end of the [transition period], and in particular the balance between stock-holding in the UK, re-routing away from the short straits and readiness for new customs and border arrangements.

"We recognise that global supply chains are under significant pressure, exacerbated by recent events with COVID-19. However, we encourage companies to make stockpiling a key part of contingency plans, and ask industry, where possible, to stockpile to a target level of 6 weeks total stock on UK soil. DHSC stands ready to support companies with their plans if required and understands that a flexible approach to preparedness may be required that considers a mixture of stockpiling and rerouting plans as necessary."

But the memo reported earlier in the year from the pharmaceutical industry warned that there would be less or zero product available in the market to allow for stockpiling a broad range of products thanks to the pandemic.

It continued: We would warn against any drastic policies mandating wholesale changes to global supply chains, as this could fundamentally disrupt the supply of medicines for the NHS and patients in other countries."

Pro-Brexit supporters celebrating in Parliament Square, after the UK left the European Union on 31 January. Ending 47 years of membership

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Big Ben, shows the hands at eleven o'clock at night

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Pro Brexit supporters attend the Brexit Day Celebration Party hosted by Leave Means Leave

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Brexit Party leader Nigel Farage smiles on stage

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People celebrate in Parliament Square

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A Brexit supporter celebrates during a rally in Parliament square

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Police form a line at Parliament Square to prevent a small group of anti-Brexit protestors from going through to the main Brexit rally

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Nigel Farage speaks to pro-Brexit supporters

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JD Wetherspoon Chairman Tim Martin speaks as people wave flags

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Brexit supporters wave Union flags as they watch the big screen

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Brexit Party leader, Nigel Farage arrives

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Brexit supporters gather

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Ann Widdecombe speaks to pro-Brexit supporters

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Brexit supporters wave Union flags as they watch the big screen

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People wave British Union Jack flags as they celebrate

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Pro-Brexit demonstrators celebrate on Parliament Square on Brexit day

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A pro-Brexit supporter jumps on an EU flag

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AFP via Getty

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A man waves Union flags from a small car as he drives past Brexit supporters gathering

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A pro-Brexit supporter pours beer onto an EU flag

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An EU flag lies trampled in the mud

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AFP via Getty

Pro-Brexit supporters celebrating in Parliament Square, after the UK left the European Union on 31 January. Ending 47 years of membership

PA

Big Ben, shows the hands at eleven o'clock at night

AFP via Getty

Pro Brexit supporters attend the Brexit Day Celebration Party hosted by Leave Means Leave

Getty

Brexit Party leader Nigel Farage smiles on stage

AFP/Getty

People celebrate in Parliament Square

Reuters

A Brexit supporter celebrates during a rally in Parliament square

AP

Police form a line at Parliament Square to prevent a small group of anti-Brexit protestors from going through to the main Brexit rally

PA

Nigel Farage speaks to pro-Brexit supporters

PA

PA

JD Wetherspoon Chairman Tim Martin speaks as people wave flags

Reuters

Getty

Brexit supporters wave Union flags as they watch the big screen

AFP via Getty

Brexit Party leader, Nigel Farage arrives

Reuters

Brexit supporters gather

AP

Ann Widdecombe speaks to pro-Brexit supporters

PA

Brexit supporters wave Union flags as they watch the big screen

AFP via Getty

AFP via Getty

People wave British Union Jack flags as they celebrate

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Government says medicines must be stockpiled for no-deal Brexit on top of Covid-19 pressures - The Independent

Brexit will deliver double shock to UK economy, study finds – The Guardian

A Brexit hit is looming for sectors that have emerged relatively unscathed from the Covid-19 pandemic, analysis by the London School of Economics suggests.

The LSE report says Brexit will deliver a double shock to the economy with business conditions worsening for those sectors that have survived the impact of coronavirus and lockdown measures whether Boris Johnson secures a deal with the EU or not.

The analysis, seen by the Guardian before its publication on Wednesday, includes information from a monthly survey of Confederation of British Industry members.

Our analysis shows that the sectors that will be affected by Brexit and those that are suffering from the Covid-19 pandemic and lockdown are generally different from each other, said Swati Dhingra, an economics professor who co-authored the report.

A simultaneous impact from Brexit and coronavirus will be felt across the business spectrum from the autumn when the chancellor Rishi Sunaks pandemic policies aimed at supporting the unemployed end and the new trading environment for the UK outside the EU begins to bite, the research finds.

The report, Covid-19 and Brexit: Real-Time Updates on Business Performance in the United Kingdom by the LSEs Centre for Economic Performance, shows sectors that entail more human contact including hospitality, air travel, restaurants, hotels, and arts and entertainment have been the hardest hit by the pandemic.

The affect on other sectors such as the scientific industries, professional services, including accountancy and legal services, and publishing has been less severe because they can continue to operate with staff working from home.

Among those reportedly continuing to operate with remote working are firms such as Vodafone, Google, the accountancy firm KPMG, GlaxoSmithKline, Rolls-Royce and the consumer goods group Unilever.

But Brexit will impose barriers on those trading goods or services with the EU, whether it is pharmaceutical companies seeking regulatory approval, banks or services needing to transfer data from servers in the bloc or car manufacturers or clothes importers being required to fill in customs declarations for the first time in decades.

The report points out that as far back as 2017 the government announced that Brexit would be guided by impact assessments across sectors; it has provided detailed analysis in only 10 sectors to date.

The government must move beyond its broad assessment of Brexit impacts to much more finely tuned plans in preparation for the biggest slowdown of our lifetime said Josh de Lyon, a research assistant at the LSE centre who co-authored the report.

Dhingra said the coronavirus pandemic had reduced the capacity of the UK economy to take further shocks, and rushing Brexit through would broaden the set of sectors that experienced worsening business conditions.

Using monthly data collected by the CBI on business experiences and expectations of growth or declines, along with what it describes as state of the art modelling, the centre has been able to assess the outlook for the next three months.

LSE, like other big institutions, is loath to put a figure on the projected combined shock to the economy although various sectors have warned of hardship coming down the tracks. The manufacturing body Make UK warned that more than half of the manufacturing sector was planning redundancies when the business support schemes ended.

The LSE report urges the government to put in place an industrial strategy that must reflect the cold reality of being in a post-Brexit UK which is placed in a post-Covid world economy in which global trade shrinks.

Read more:

Brexit will deliver double shock to UK economy, study finds - The Guardian

From the C to the B – Putting the B back in Brexit – Finextra

Do you remember when Brexit dominated almost every element of the daily discourse? Every headline, every TV news story, every social media link involved the B-word. Half of all conversations touched upon or outright focussed on the latest B-news. You could barely look a computer, a billboard or dare I say a bus without seeing B-stuff. It was almost a relief when you looked at a news outlet and something dramatic had happened because at least it afforded some slight respite from bloody Brexit!

Then in true Sesame Street fashion, the next episodes of life were brought to us by the letter C and as well as the actual pandemic there was a pandemic of coverage. C-themed stories were everywhere and the deluge of C-topics washed away all those B-stories. Ok, this is not entirely true as there were one or two B-C-stories such as our transition deal membership of the EU keeping UK food supplies moving, the contribution of EU nurses to our heroic NHS frontline and the failure to accept the EUs help with PPE. But Im sailing dangerously close to the political line that business commentators are best avoiding. In an effort to navigate back to safer waters and reinforce my theme, lets just agree that pesky C pushed troublesome B off of the agenda.

Bringing it

Well the good news is that Im bringing back Brexit!

Admittedly, this is probably only good news if you are totally fed up with crummy COVID (almost certainly yes). Are nostalgic for all the Brexit talk (pretty sure youre not). Or involved in banking and wondering how to dispose of that excess budget this year (guess thats probably nope too).

So why do we want to discuss Brexit? Simple. Its the end of July. That simple really. The real question is why arent we discussing Brexit?

Barring a spectacular change in direction (though 2020 so far has taught me not to ruleanything out) this Brexit business happens in 5 short months. The remainder of this article focuses on what that means for regulatory transaction reporting.

The bamboo chopping board of fate

At the 30,000 feet level, there is currently an EU-wide implementation of EMIR, MiFIR and SFTR that covers the 27 EU countries plus the UK. At the stroke of midnight on December 31st the hand of fate takes a meat cleaver and chops each of these three regimes into two very similar, but nonetheless distinct versions. Whilst many are raising their festive glasses to the new year, UK/FCA versions of EMIR, SFTR & MiFIR will come into being.

The following morning when many are nursing sore heads, the ESMA or EU-27 countries versions of these three regulations will similarly be facing the hangover of being greatly diminished and disrupted by the departure of Britannia. 28 minus one might not seem a big margin but its hard to overstate the contribution of the UK financial markets in the European context. With all due respect London is more comparable to New York or Tokyo, than say Paris, Frankfurt or Madrid.

Infantile problems

Phases 1 & 2 of SFTR went live earlier this month so its basically a newborn, screaming a lot and causing sleepless nights. Phase 3 goes lives in October. By December SFTR is a toddler at best. Many firms will still be busy with early remediation items and bedding down the controls, data and processes around SFTR. But nonetheless it will be split into UK-SFTR and EU-SFTR and many of those firms will need to adapt to a new landscape.

The Trade Repositories will offer separate UK and EU TR businesses. Each with separate connectivity, onboarding, reports and so on. The regulation itself insists upon Operational Separation so the firms running the TRs have no choice but to separate them out. Adapting your brand new reporting solution to start sending some transaction reports to a different TR and integrating all the responses and reports back from the new TR is a considerable undertaking. Especially for the firms that have yet to catch their breath from the October phase going live.

The EMIR regulation also gets split into European EMIR and UKMIR. Ok I might have made that last bit up and UK-EMIR or FCA-EMIR is more accurate nomenclature for the UK slice. But in these crazy times Im not sure Id fully rule out the UK tabloids campaigning to kick the E out of our sovereign Market Infrastructure Regulation.

Splitting their EMIR reporting into two versions is slightly less fraught for the reporting firms compared to SFTR, as EMIR is a much more mature regulation. But as well as separate UK/EU Trade Repositories, connectivity and so forth there are other challenges to consider. What about the impact on Delegated Reporting for firms either offering a delegated service or firms utilizing such a service? What about the explicit permissions that was implemented earlier this year? Firms need to ensure they have the appropriate explicit permissions at each TR for the appropriate clients.

Fitting in the REFIT

And what about the EMIR REFITs introduction of Mandatory Delegated Reporting which, as of last month, means the FC (Bank or large dealer) selling OTC derivatives to an NFC- (small non-financial firm below the clearing threshold) has a mandatory obligation to report on behalf of the smaller firm. This was introduced to make the burden on the smaller firms more appropriate. But what happens when the Bank/Dealer finds themselves on a different EMIR jurisdiction to their NFC- client? For example, a London based bank facing a small continental based manufacturing company where the bank falls under the UK-EMIR and their client falls under the EU-EMIR. The mandatory element is gone but the desire to service the client surely remains.

The REFIT is also very much an inflight initiative with many more changes coming including potentially new fields and the introduction of an ISO 20022 schema that Ive been predicting for the lastfour years. On the 1st of January 2021 the EU & UK versions of EMIR will be essentially carbon copies of each other. But each jurisdiction has the potential to diverge and any of the many firms caught with obligations to report to both will need to deal with any divergence. The REFIT is the most obvious example of potential divergence but it only takes an update to the ESMA EMIR Q&As, the ESMA validation rules or the FCA to publish its own guidance and the two versions will be branching off in different directions. There is a slight possibility the FCA and ESMA try to collaborate and agree any changes in common but that looks like a slim chance currently.

The Cheeseboard

And last but by no means least there is the MiFIR regulation or rather the reporting components of the MiFID 2 regulation. The Brexit cheese wire will split this regulation into UK cheddar and EU mozzarella slices. Under MiFIR Transaction Reporting, firms have the option of reporting directly to their home country regulator or reporting via an Approved Reporting Mechanism (ARM).

This reporting directly to the home regulator will alleviate a lot of the disruption to MiFIR reporting firms. However, the ARMs and the firms using them are impacted similarly to the TRs under EMIR & SFTR and in order to provide ARM services for EU firms the ARM needs to be located within an EU country. Many of the ARMs will need to split their offerings into a UK based one and an EU based one.

Anyone familiar with MiFIR reporting will also be aware that firms are dependent on data aggregated by the various regulators across the EU and published by ESMA. For example the Financial Instrument Reference Data (FIRDs) or Financial Instrument Transparency System (FITS) data which ESMA is mandated to publish are key inputs into firms MiFIR reporting. Brexit impacts a few things here. Firstly, the UK data that currently feeds into this system will end and needs decoupled. Secondly the FCA needs to start publishing the UK only version of this data to support UK firms with their UK-MiFIR reporting obligations. The firms themselves need to adapt and configure their systems appropriately for the new data feeds landscape.

And thats just the summary

All the issues mentioned above are the simplified big picture items. In a globalised world with the European financial infrastructure so closely interlinked, the reality will be a lot more complicated for most firms. Very few of the medium to bigger sized firms will have the luxury of falling neatly into UK regulations or EU regulations. The majority will need to deal with both after the Brexit bifurcation.

Im frankly curious why this topic is not getting more coverage. Part of me wonders if some firms are in denial, given how much work and expenditure went into preparing for the previous 2019 March 29th date. [Though I still think the go-live date of April 1st 2019 is the more apt date for that one]. Is there a danger that having put so much work into something that didnt happen that firms are awaiting another Hail Mary event to postpone the pain? Or is it more a case that the heavy lifting was done for the previous deadline and firms are simply dusting down the previous plans and updating them?

Regardless, its time to start discussing the B word again. And no, I dont mean Boris!

The rest is here:

From the C to the B - Putting the B back in Brexit - Finextra

Brexit Tears: A pithy political collection of images and clever wordplay – The National

BREXIT Tears is published by Kettillonia, the small press run by the novelist James Robertson. I wrote about Robertsons novels in The National in an essay called Pushing boundaries (June 10, 2019).

Brexit Tears pushes boundaries of a different kind from those encountered in Robertsons novels.

Its a collection of images by Calum Colvin, the artist and professor of Fine Art Photography at the University of Dundee, along with a series of epigrammatic puns by Robert Crawford, the poet and professor of Modern Scottish Literature at St Andrews University.

Words and images talk to each other through forceful but ambiguous meanings. The words themselves engage ambiguity while emphasising the value of judgment. We can enjoy the playfulness, but they also sustain protest and lament, both angry and determined.

The work is resigned: there is no sentimental wishfulness about what we have failed to prevent (at least, so far, in Scotland), but there is also a sense of why we need to keep resisting it. The lament is there in the title: tears are being shed, but the sheer tearing away, the violence in the word tears (whats being torn) is registered as well.

The book is beautifully produced, on silk art paper, with bold upper case lettering and brightly coloured, sharp and vivid pictures. But the cover, white letters on a black background, is as stark and decisive as a headstone. Consider a few examples of the texts.

LEAVE.CON

ITS impact is instantaneous and should need no further comment. However, as the great American poet William Carlos Williams once said, You should never explain a poem, but it always helps.

Were surely all or almost all of us aware of email addresses that end in dotcom or literally .com and its easy to mistake the m sound for an n sound, so you might look twice before you see what should be obvious.

And thats how con-tricks work. Con as in confidence: the trick is to seduce you into having confidence in something you should be sceptical about, that you should not trust for a moment for a moment is all it takes. Brexit is surely the biggest Leave con-trick of them all (Like Better Together answer: Stronger Apart).

The letters on the page pun and provoke, back and forth, covering years of Westminster government ineptitude, malevolent self-servicing intention, and skilful manipulation (because it has operated effectively). The meanings the letters construct employ all these things and more.

Ali Smith once said she grew up with an appetite for reading everything she could see, the side of a cornflakes packet, the side of a pencil, the side of a bus. If only more people could have read the side of a bus, truthfully.

SCOTTISH LABOUR PAINS

AN interface: Scottish Labour and labour pains: two pairs of words that should belong in different worlds, you might think. Bring them together and theres a judgment: Scottish Labour pains because its so awful, so evasive of necessary questions, and its history of Unionism has been horrible to see unfolding.

But remember the actual birth of the Labour Party through the potency of the Labour movement, breaking through from the Liberal Party as once was in the 19th century into outright opposition to class privilege and entitlement which the Conservative and Unionist Party stood and still stands for.

Labours formation began with the Scottish Labour Party in 1888, then the Independent Labour Party in 1895, and only then the Labour Party as such in 1906.

WE might recollect the founders, Keir Hardie and RB Cunninghame Graham. In their day, more than 100 years ago, home rule and independence were Labour priorities, to break up the British Empire and its history of exploitation, and to establish rights for working men and women.

Do the three words of the poem suggest even fancifully that a truly Scottish Labour Party might even yet begin to feel its own birth pangs returning? Perhaps a sufficient number of party members believe in Scottish independence to suggest that its possible. If so, it would be a fulfilment of Cunninghame Grahams practical insistence that the Labour movement and the vision of an independent Scotland could only realise something valuable by working together.

BREXIT WITHDRAW ALL AGREEMENT

WITHDRAWAL Agreement is replaced by its opposite meaning, Withdraw All Agreement, which seems no more than a fair description and as pessimistic as you might imagine. Then you might ask how the words connect with the terrifying suggestion in the image.

UNTIED KINGDOM

AND the positive sense of breaking free from an imprisonment, liberation from diminishment and limitation, is surely a positive prospect. But the warning remains.

WAR IS JOHNSON

AND a much larger sense of neither dependence not isolationism is affirmed in the idea of interdependence, which requires both individual nations and internationalism.

ECOSSE YOURE WORTH IT

AND to illustrate that, instead of the insidious lie of the advertising campaign (buy this for the sake of your self-esteem: BECAUSE), we have the understanding that Scotland is multiple, seen through the French language (Ecosse), or implicitly as it might be understood through any number of languages in the world, in its own right, in an international context.

YOUR COUNTRY NEEDS EU

IN her novel Spring, Ali Smith writes: Now what we dont want is Facts. What we want is bewilderment. What we want is repetition. What we want is repetition. What we want is people in power saying the truth is not the truth and We need it not to matter what words mean. And: Were what this countrys needed all along ,were what you need, were what you want.

This book reminds us that we want something else.

Brexit Tears costs 10 (including postage and packing) via PayPal from http://www.kettillonia.co.uk

Payment by cheque is also possible by arrangement with the publisher.

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Brexit Tears: A pithy political collection of images and clever wordplay - The National

‘The younger the child, the likelier to find causative gene of infant epilepsy’ – Korea Biomedical Review – Korea Biomedical Review

A research team at Samsung Medical Center has found that the younger the patients age, the higher the probability of finding the causative gene of infant epilepsy.

Epilepsy is a neurological disease caused by a variety of causes. However, it is difficult to find the cause of the outbreak, and hospitals conduct various tests and treatment methods to customize treatment for each patient. In some cases, patients develop epilepsy at a very young age, despite their brain MRI test results coming back normal. There remain high unmet needs for a diagnosis to establish the cause.

To resolve the issue, the team, led by Professors Lee Ji-won and Lee Ji-hoon, conducted a genetic panel test using next-generation sequencing on 116 patients under two years of age diagnosed with epilepsy despite having a normal brain MRI.

As a result of the study, the probability of finding the cause gene through genetic panel examination was 34.5 percent for patients under two years of age, 39.6 percent for those under one year old, and 50 percent for babies under six months old.

Until now, it was common for patients, who had epilepsy despite having a normal brain MRI, to receive antiepileptic drugs, the team said. Based on the results of this study, however, we think we have paved the way for selecting an appropriate drug according to the mutation of the causal gene.

In an additional study involving 13 benign rolandic epilepsy patients, the researchers could also diagnose the patients early and quickly provide optimal drugs, it added.

Although more than 50 percent of patients have yet to find the cause of their disease, the team expects to find more causal genes through the ongoing familial genome research, Professor Lee Ji-won said. To establish effective customized treatments, research is underway to produce a cell model that expresses the phenotype of a patient whose causative gene has been identified and screen the therapeutic agent.

Professor Lee Ji-hoon also said, Identifying the genes that cause epilepsy through the diagnostic capabilities of pediatrics clinicians can be a crucial aid in selecting therapeutic drugs, allowing doctors to predict to some extent what prognosis the young patients will show as they grow up.

Molecular Genetics & Genomic Medicine has published the results of the study.

corea022@docdocdoc.co.kr

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Known genes associated with male infertility doubled – BioNews

3 August 2020

Thirty-three genes associated with male infertility have been identified through a 'genomics-first' approach to understanding the condition.

Researchers from the King Faisal Specialist Hospital and Research Centre in Saudi Arabia used exomesequencing, a method for sequencingall the protein-coding regions of genesin a genome, to establish a genetic basis for infertility in male patients. It is hoped that a more complete understanding of the molecularbiology behind male infertility, alongside greater application of genomic medicine, will lead to improvements in treatment and diagnosis.

'Male factors account for nearly half of infertility caseswith nearly seven percent of the male population estimated to suffer from infertility' the authors reported in the journal Genetics in Medicine. 'However, current estimates of the contribution of genetics to male infertility (15 percent) suffer from the lack of comprehensive genomic analysis in large cohorts.'

From a non-selected sample of 285 infertile male patients, 69 (24.2 percent) were suspected of displaying a monogenic form of male infertility, meaning that it was caused by a defect in a single gene. Over 400 genes have already been associated with male infertility in mouse models, suggesting that that the monogenic contribution in humans has been significantly underestimated.

The current standard method for diagnosing the cause of male infertility involves screening for chromosomal aberrations, such as Y-chromosome micro-deletions too small to spot by karyotype. However, this technique has a low diagnostic yield, and aberrations were only identified in 30 (10.5 percent) of the patients included in the study.

Of the 285 patients included in the study, 237 presented with non-obstructive azoospermia a failure to make sperm resulting in no sperm in the ejaculate. The remaining 48 patients displayed severe oligospermia, characterised by a sperm count lower than one million sperm per millilitre. An identical number of fertile men were recruited to the study as controls.

'The 33 candidate genes we identified in this study represents by far the largest number of male infertility genes discovered by a single study,' Dr Fowzan Alkuraya, the principal clinical scientist behind the study toldGenomeWeb. 'There are only around 40 genes linked to non-obstructive azoospermia in humans. Thus, our study nearly doubles the genes linked to this phenotype.'

These candidate genes were also selected and verified based on known biological roles in male germ celldevelopment, as well as from compatible mouse models. Three of these genes were deemed as having 'strong evidence' of a connection to male infertility in humans, based on evidence from mouse models, as well as displaying independent variants in multiple unrelated patients.

The scientists are hopeful that these results will encourage further research dissecting the molecular basis of male infertility, as well as the development of future therapies and methods to improve its diagnosis and management.

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Known genes associated with male infertility doubled - BioNews

Alnylam Submits CTA Application for ALN-HSD, an Investigational RNAi Therapeutic for the Treatment of Nonalcoholic Steatohepatitis (NASH) – Business…

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics company, announced today that the Company has submitted a clinical trial authorization (CTA) application to The Medicines and Healthcare Products Regulatory Agency (MHRA) in the United Kingdom to initiate a Phase 1 study of ALN-HSD, an investigational RNAi therapeutic targeting HSD17B13 for the treatment of nonalcoholic steatohepatitis (NASH). The Company plans to initiate a Phase 1 study in late 2020, upon obtaining MHRA approval.

We are excited to advance our ALN-HSD program to the clinic in partnership with Regeneron, particularly given the mass prevalence and high unmet need in NASH, a progressive disease associated with high morbidity and mortality. Given the genetic validation of the target, we believe ALN-HSD has the potential to change the course of this serious and potentially life-threatening disease for which there are currently no approved pharmacologic treatment options, said David Erbe, Ph.D., Senior Distinguished Investigator, Program Leader, ALN-HSD program at Alnylam. Pending feedback from the MHRA, we look forward to initiating the Phase 1 study to evaluate the safety and preliminary pharmacodynamic activity of ALN-HSD in healthy volunteers and patients with NASH.

About ALN-HSD

ALN-HSD is an investigational, subcutaneously administered RNAi therapeutic targeting HSD17B13 in development in collaboration with Regeneron Pharmaceuticals for the treatment of nonalcoholic steatohepatitis. ALN-HSD utilizes Alnylam's Enhanced Stabilization Chemistry Plus (ESC+) GalNAc-conjugate technology, which enables subcutaneous dosing with increased selectivity and a wide therapeutic index. The safety and efficacy of ALN-HSD have not been evaluated by the FDA, EMA or any other health authority.

About NASH

Nonalcoholic steatohepatitis (NASH) is a highly prevalent chronic liver disease in which inflammation and liver cell injury are caused by accumulation of hepatic fat. NASH is a subset of a group of conditions called nonalcoholic fatty liver disease (NAFLD) that can lead to progressive fibrosis, cirrhosis, and hepatocellular carcinoma. Comorbidities include obesity, metabolic syndrome, and type 2 diabetes. Approximately 16 million people in the US live with NASH, with prevalence of the disease increasing due to rising rates of obesity. NASH is projected to be the leading indication for liver transplants in developed countries within the next 10 years. There are currently no approved medical therapies for NASH.

About RNAi

RNAi (RNA interference) is a natural cellular process of gene silencing that represents one of the most promising and rapidly advancing frontiers in biology and drug development today. Its discovery has been heralded as "a major scientific breakthrough that happens once every decade or so," and was recognized with the award of the 2006 Nobel Prize for Physiology or Medicine. By harnessing the natural biological process of RNAi occurring in our cells, a new class of medicines, known as RNAi therapeutics, is now a reality. Small interfering RNA (siRNA), the molecules that mediate RNAi and comprise Alnylam's RNAi therapeutic platform, function upstream of todays medicines by potently silencing messenger RNA (mRNA) the genetic precursors that encode for disease-causing or disease pathway proteins, thus preventing them from being made. This is a revolutionary approach with the potential to transform the care of patients with genetic and other diseases.

About Alnylam Pharmaceuticals

Alnylam (Nasdaq: ALNY) is leading the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare genetic, cardio-metabolic, hepatic infectious, and central nervous system (CNS)/ocular diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach for the treatment of a wide range of severe and debilitating diseases. Founded in 2002, Alnylam is delivering on a bold vision to turn scientific possibility into reality, with a robust RNAi therapeutics platform. Alnylams commercial RNAi therapeutic products are ONPATTRO (patisiran), approved in the U.S., EU, Canada, Japan, Brazil, and Switzerland, and GIVLAARI (givosiran), approved in the U.S., EU, and Brazil. Alnylam has a deep pipeline of investigational medicines, including six product candidates that are in late-stage development. Alnylam is executing on its "Alnylam 2020" strategy of building a multi-product, commercial-stage biopharmaceutical company with a sustainable pipeline of RNAi-based medicines to address the needs of patients who have limited or inadequate treatment options. Alnylam is headquartered in Cambridge, MA. For more information about our people, science and pipeline, please visit http://www.alnylam.com and engage with us on Twitter at @Alnylam or on LinkedIn.

Alnylam Forward-Looking Statements

Various statements in this release concerning Alnylam's future expectations, plans and prospects, including, without limitation, the potential of investigational RNAi therapeutics, in particular ALN-HSD, Alnylam's filing of a CTA for ALN-HSD and its expectations regarding the anticipated timing for initiation of a Phase 1 study of ALN-HSD, and expectations regarding the continued execution on its Alnylam 2020 guidance for the advancement and commercialization of RNAi therapeutics, constitute forward-looking statements for the purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. Actual results and future plans may differ materially from those indicated by these forward-looking statements as a result of various important risks, uncertainties and other factors, including, without limitation: the direct or indirect impact of the COVID-19 global pandemic or a future pandemic, such as the scope and duration of the outbreak, government actions and restrictive measures implemented in response, material delays in diagnoses of rare diseases, initiation or continuation of treatment for diseases addressed by Alnylam products, or in patient enrollment in clinical trials, potential supply chain disruptions, and other potential impacts to Alnylams business, the effectiveness or timeliness of steps taken by Alnylam to mitigate the impact of the pandemic, and Alnylams ability to execute business continuity plans to address disruptions caused by the COVID-19 or a future pandemic; Alnylam's ability to discover and develop novel drug candidates and delivery approaches and successfully demonstrate the efficacy and safety of its product candidates; the pre-clinical and clinical results for its product candidates, which may not be replicated or continue to occur in other subjects or in additional studies or otherwise support further development of product candidates for a specified indication or at all; actions or advice of regulatory agencies, which may affect the design, initiation, timing, continuation and/or progress of clinical trials or result in the need for additional pre-clinical and/or clinical testing; delays, interruptions or failures in the manufacture and supply of its product candidates, including ALN-HSD, or its marketed products; obtaining, maintaining and protecting intellectual property; intellectual property matters including potential patent litigation relating to its platform, products or product candidates; obtaining regulatory approval for its product candidates, including ALN-HSD, and maintaining regulatory approval and obtaining pricing and reimbursement for its products, including ONPATTRO and GIVLAARI; progress in continuing to establish a commercial and ex-United States infrastructure; successfully launching, marketing and selling its approved products globally, including ONPATTRO and GIVLAARI, and achieving net product revenues for ONPATTRO within its revised expected range during 2020; Alnylams ability to successfully expand the indication for ONPATTRO in the future; competition from others using technology similar to Alnylam's and others developing products for similar uses; Alnylam's ability to manage its growth and operating expenses within the ranges of guidance provided by Alnylam through the implementation of further discipline in operations to moderate spend and its ability to achieve a self-sustainable financial profile in the future without the need for future equity financing; Alnylams ability to establish and maintain strategic business alliances and new business initiatives, including completing an agreement for funding by Blackstone of certain R&D activities for vutrisiran and ALN-AGT; Alnylam's dependence on third parties, including Regeneron, for development, manufacture and distribution of certain products, including eye and CNS products, Ironwood, for assistance with the education about and promotion of GIVLAARI, and Vir for the development of ALN-COV and other potential RNAi therapeutics targeting SARS-CoV-2 and host factors for SARS-CoV-2; the outcome of litigation; the risk of government investigations; and unexpected expenditures; as well as those risks more fully discussed in the "Risk Factors" filed with Alnylam's most recent Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (SEC) and in other filings that Alnylam makes with the SEC. In addition, any forward-looking statements represent Alnylam's views only as of today and should not be relied upon as representing its views as of any subsequent date. Alnylam explicitly disclaims any obligation, except to the extent required by law, to update any forward-looking statements.

ALN-HSD has not been evaluated by the FDA, EMA, or any other regulatory authority and no conclusions can or should be drawn regarding the safety or effectiveness of this investigational therapeutic.

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Alnylam Submits CTA Application for ALN-HSD, an Investigational RNAi Therapeutic for the Treatment of Nonalcoholic Steatohepatitis (NASH) - Business...

Cancer drug is first therapy to emerge from 23andMe-GSK deal – STAT – STAT

The pharmaceutical giant GlaxoSmithKline is starting human trials of the first medicine, a cancer drug, that has emerged from its two-year-old collaboration with consumer genetics firm 23andMe.

The novel partnership focuses on using 23andMes massive genetic database, composed of the test results and self-reported health data from 12 million consumers who have taken its tests to learn about their ancestry and a smattering of disease-related genes, and who have said their samples could be used in research. GSK uses the database to try and validate genes and proteins that could be what researchers call targets for new drugs that is, the proteins and other molecules whose functions medicines block or otherwise change.

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Dr. Rana on the Rationale for Video Genetic Counseling in Prostate Cancer – OncLive

Huma Q. Rana, MD, MPH, discusses the rationale for the ProGen trial, which compared the effectiveness of video education versus in-person genetic counseling for men with prostate cancer.

Huma Q. Rana, MD, MPH, anassistant professor of medicine at Harvard Medical School andclinical directorofCancer Genetics and Prevention at Dana-Farber Cancer Institute, discusses the rationale for the ProGen trial, which compared the effectiveness of video education versus in-person genetic counseling for men with prostate cancer.

There are increasing indications for germline genetic testing in prostate cancer, says Rana. Through several clinical studies, the field has recognized that there is a high prevalence of inherited mutations among men with advanced prostate cancers, and this could have significant implications on treatment. Men with advanced prostate cancer, particularly those with underlying mutations in genes such asBRCA2, are known to have poor outcomes, says Rana. Therefore, it is important to identify these men and make matched targeted therapy available to them and their oncologists.

In recognizing that prostate cancer is a very common disease and that traditional germline genetic testing would be very difficult to implementpotentially overwhelming already strained systems for genetic testinga randomized controlled trialwas conducted. In the trial, investigators compared the effectiveness of a short videothat focused on the educational components of a genetic counseling visit with in-person genetic counseling for men with potentially lethal prostate cancers, concludes Rana.

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Dr. Rana on the Rationale for Video Genetic Counseling in Prostate Cancer - OncLive

Metastatic Lung Cancer Study Finds That Bionano’s Saphyr Outperforms NGS for the Detection of Structural Variants – GlobeNewswire

SAN DIEGO, Aug. 03, 2020 (GLOBE NEWSWIRE) -- Bionano Genomics, Inc. (Nasdaq: BNGO), today announced the publication of the first study to utilize its genome imaging system, Saphyr, for the analysis of structural variants (SVs) in lung cancer and metastases. The study, published in Translational Lung Cancer Research by a team of scientists from Fudan University Shanghai Cancer Center and Shanghai Medical College, analyzed SVs using both short-read next-generation sequencing technology (NGS) and Bionanos Saphyr system on a primary lung squamous cell carcinoma sample, and on matched metastases from lymph node and pulmonary vein. The study showed that Saphyr outperformed NGS-based methods in the detection of structural variants to characterize the genetic heterogeneity between the primary tumor and the matched metastases.

Of 1026 large SVs detected on average by Saphyr in each of the tumor types, the NGS-based methods failed to detect an average of 77%. Saphyr identified 52 SVs shared between the metastases, while no shared SVs were found by NGS-based methods.

The study authors stated that Saphyr is more capable of detecting large and complex SVs, without the computational and bioinformatic challenges that come with SV calling from NGS data. They found that like with point mutations and small insertions/deletions detected with NGS, SVs make up a large part of tumor heterogeneity. The authors describe that the combination of NGS and Saphyr allowed for a more comprehensive understanding of the variation between primary tumor and metastases, with Saphyr making up for the inability of NGS to detect large SVs.

Erik Holmlin, Ph.D., CEO of Bionano Genomics commented: Researchers are increasingly becoming aware of the importance of genome-wide and unbiased detection of structural variants in cancer and of the severe limitations of NGS-based methods to do so.We are pleased to see this publication showing that Saphyr provided a comprehensive view of structural variants in lung cancer, the most commonly occurring cancer worldwide.Unlike short-read sequencing protocols which start with fragmenting the genomic DNA of the tumor, Bionanos genome imaging analyzes long, intact DNA molecules that are hundreds of thousands to millions of basepairs long, which enables Saphyrto detect structural variants that couldnt be identified before. We believe this study and the growing body of publications on Bionano data show that Saphyr is indispensable for personalized medicine and for furthering the understanding of tumorigenesis and cancer progression.

The study is available at http://tlcr.amegroups.com/article/view/40176/html.

About Bionano Genomics

Bionano is a genome analysis company providing tools and services based on its Saphyr system to scientists and clinicians conducting genetic research and patient testing. Bionanos Saphyr system is a platform for ultra-sensitive and ultra-specific structural variation detection that enables researchers and clinicians to accelerate the search for new diagnostics and therapeutic targets and to streamline the study of changes in chromosomes, which is known as cytogenetics. The Saphyr system is comprised of an instrument, chip consumables, reagents and a suite of data analysis tools, and genome analysis services to provide access to data generated by the Saphyr system for researchers who prefer not to adopt the Saphyr system in their labs. For more information, visitwww.bionanogenomics.com.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as may, will, expect, plan, anticipate, estimate, intend and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) convey uncertainty of future events or outcomes and are intended to identify these forward-looking statements. Forward-looking statements include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: Saphyrs capabilities in comparison to NGS-based methods; and Saphyrs potential as an indispensable tool for personalized medicine and furthering understanding of cancer in the medical community. Each of these forward-looking statements involves risks and uncertainties. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the risks and uncertainties associated with: the impact of the COVID-19 pandemic on our business and the global economy; general market conditions; changes in the competitive landscape and the introduction of competitive products; changes in our strategic and commercial plans; our ability to obtain sufficient financing to fund our strategic plans and commercialization efforts; the loss of key members of management and our commercial team; and the risks and uncertainties associated withour business and financial condition in general, including the risks and uncertainties described in our filings with the Securities and Exchange Commission, including, without limitation, our Annual Report on Form 10-K for the year ended December 31, 2019 and in other filings subsequently made by us with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made and are based on management's assumptions and estimates as of such date. We do not undertake any obligation to publicly update any forward-looking statements, whether as a result of the receipt of new information, the occurrence of future events or otherwise.

CONTACTSCompany Contact:Erik Holmlin, CEOBionano Genomics, Inc.+1 (858) 888-7610eholmlin@bionanogenomics.com

Investor Relations Contact:Ashley R. RobinsonLifeSci Advisors, LLC+1 (617) 430-7577arr@lifesciadvisors.com

Media Contact:Kirsten ThomasThe Ruth Group+1 (508) 280-6592kthomas@theruthgroup.com

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Metastatic Lung Cancer Study Finds That Bionano's Saphyr Outperforms NGS for the Detection of Structural Variants - GlobeNewswire