Human reproduction – Wikipedia

Human reproduction is any form of sexual reproduction resulting in human fertilization, typically involving sexual intercourse between a man and a woman. During sexual intercourse, the interaction between the male and female reproductive systems results in fertilization of the woman's ovum by the man's sperm. These are specialized reproductive cells called gametes, created in a process called meiosis. While normal cells contains 46 chromosomes, 23 pairs, gamete cells only contain 23 chromosomes, and it is when these two cells merge into one zygote cell that genetic recombination occurs and the new zygote contains 23 chromosomes from each parent, giving them 23 pairs. After a gestation period, typically for nine months, is followed by childbirth. The fertilization of the ovum may be achieved by artificial insemination methods, which do not involve sexual intercourse.

The male reproductive system contains two main divisions: the testes where sperm are produced, and the penis. In humans, both of these organs are outside the abdominal cavity. Having the testes outside the abdomen facilitates temperature regulation of the sperm, which require specific temperatures to survive about 2-3C less than the normal body temperature i.e. 37C. In particular, the extraperitoneal location of the testes may result in a 2-fold reduction in the heat-induced contribution to the spontaneous mutation rate in male germinal tissues compared to tissues at 37C.[1] If the testicles remain too close to the body, it is likely that the increase in temperature will harm the spermatozoa formation, making conception more difficult. This is why the testes are carried in an external pouch viz. scrotum rather than within the abdomen; they normally remain slightly cooler than body temperature, facilitating sperm production.

The female reproductive system likewise contains two main divisions: the vagina and uterus, which will receive the semen, and the ovaries, which produces the ova. The vagina is attached to the uterus through the cervix, while the uterus is attached to the ovaries via the Fallopian tubes. At certain intervals, the ovaries release an ovum, which passes through the fallopian tube into the uterus.

The fertilization of the ovum with the sperm occurs at the ampullary-isthimic junction only. That is why not all intercourse results in pregnancy. The ovum meets with Spermatozoon, a sperm may penetrate and merge with the egg, fertilizing it with the help of certain hydrolytic enzymes present in the acrosome. The fertilization usually occurs in the oviducts, but can happen in the uterus itself. The zygote then becomes implanted in the lining of the uterus, where it begins the processes of embryogenesis and morphogenesis. When the fetus is developed enough to survive outside the womb, the cervix dilates and contractions of the uterus propel it through the birth canal, which is the vagina.

The ova, which are the female sex cells, are much larger than the spermatozoon and are normally formed within the ovaries of the female fetus before its birth. They are mostly fixed in location within the ovary until their transit to the uterus, and contain nutrients for the later zygote and embryo. Over a regular interval, in response to hormonal signals, a process of oogenesis matures one ovum which is released and sent down the Fallopian tube. If not fertilized, this egg is flushed out of the system through menstruation.

Human reproduction normally begins with sexual intercourse, followed by nine months of pregnancy before childbirth, though it may be achieved through artificial insemination. Many years of parental care are required before a human child becomes independent, typically between twelve and eighteen or more. Pregnancy can be avoided with the use of contraceptives such as condoms and Intrauterine devices.

Human reproduction takes place as internal fertilisation by sexual intercourse. During this process, the male inserts his penis, which needs to be erect, into the female's vagina, and then either partner initiates rhythmic pelvic thrusts until the male ejaculates semen, which contains sperm, into the vaginal canal. This process is also known as "coitus", "mating", "having sex", or, euphemistically, "making love". The sperm and the ovum are known as gametes (each containing half the genetic information of the parent, created through meiosis). The sperm (being one of approximately 250 million sperm in a typical male ejaculation) travels through the vagina and cervix into the uterus or Fallopian tubes. Only 1 in 14 million of the ejaculated sperm will reach the Fallopian tube. The egg simultaneously moves through the Fallopian tube away from the ovary. One of the sperm encounters, penetrates and fertilizes the ovum, creating a zygote. Upon fertilization and implantation, gestation of the fetus then occurs within the female's uterus.[2][3][4][5]

Pregnancy is the period of time during which the fetus develops, dividing via mitosis inside the female. During this time, the fetus receives all of its nutrition and oxygenated blood from the female, filtered through the placenta, which is attached to the fetus' abdomen via an umbilical cord. This drain of nutrients can be quite taxing on the female, who is required to ingest slightly higher levels of calories. In addition, certain vitamins and other nutrients are required in greater quantities than normal, often creating abnormal eating habits. Gestation period is about 266 days in humans. While in the uterus, the baby first endures a very brief zygote stage, then the embryonic stage, which is marked by the development of major organs and lasts for approximately eight weeks, then the fetal stage, which revolves around the development of bone cells while the fetus continues to grow in size.[6]

Once the fetus is sufficiently developed, chemical signals begin the process of birth, which begins with the fetus being pushed out of the birthing canal. The newborn, which is called an Infant in humans, should typically begin respiration on its own shortly after birth. Not long after, the placenta eventually falls off on its own. The person assisting the birth may also sever the umbilical cord.

A human baby is nearly helpless and the growing child requires high levels of parental care for many years. One important type of early parental care is lactation, feeding the baby milk from the mother's mammary glands in her breasts.[7]

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Human reproduction - Wikipedia

Vitrification of Oocytes & Embryos by Suzanne Cawood Part 2 – Video


Vitrification of Oocytes Embryos by Suzanne Cawood Part 2
This lecture was part of the scientific program of IVF Lite 2011, which was held in August 2011 at Radisson Blu Resort, Goa. The landmark conference was sponsored by the IVF Lite Foundation...

By: IVF Lite Foundation

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Vitrification of Oocytes & Embryos by Suzanne Cawood Part 2 - Video

human reproduction – eschooltoday

Introduction to sexual reproduction Almost every growing up person has wondered where babies come from. If you are learning with us today, then you are probably a grown up kid and hopefully, you shall understand this bundle of excitement, and you shall learn to be more responsible in your boy-girl activities.

Reproduction generally means the action or process of making a copy of something. Human reproduction, specifically, is a wonderful, natural instance of humans making new humans (offspring) or giving birth to new humans (babies).

Reproduction is necessary for continuity of humans. This means without it, humans will no longer exist, as there will be no replacement when we grow very old and die.

There are two types of reproduction in living things

involves two individuals of the same species, usually a male and female. Asexual reproduction can occur without the involvement of another, and this is usually found in single cell organisms and in some plants.

As children grow up to become adults, their brains work with their reproductive organs to get them ready reproduce. This sexual development process takes time and it is called puberty. To understand this lesson, make sure to read about these: (Puberty For Boys, Puberty for Girls and Menstruation)

Let us start by looking at the female reproductive organ.

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human reproduction - eschooltoday

Keep calm and… stop? Fertility treatment in a pandemic – BioNews

16 March 2020

The spread of a novel coronavirus (SARS-CoV-2), which causes the disease COVID-19, presents UK fertility clinics and patients with a unique set of challenges. Some of this is because we simply don't know enough about the effects of the infection on fertility, fertility treatment and early pregnancy. Early data, summarised in the Royal College of Obstetricians and Gynaecologists guidance, are reassuring, but the number of reported cases is still small.

Clinics could face logistical challenges if large numbers of staff are unable to work due to quarantine requirements, or if elective work in hospitals is shut down to make space for emergencies. Should this prospect impact the advice we give patients? The UK Government, at the time of writing, has held back from the more radical social distancing measures implemented in other countries. This leaves clinics with a dilemma of whether to continue to offer fertility treatment to unaffected patients, or to go beyond current Government advice and suspend services.

Patients' anxieties are understandable and those who wish to delay their treatment should be accommodated. It makes sense for anyone who meets the criteria for self-isolation (which are also evolving as we write) to be advised not to start treatment and indeed to stop active treatment if already commenced.

Some would go further and say that all elective fertility treatment should be delayed. The European Society forHuman Reproduction and Embryology advises that all fertility patients should 'avoid becoming pregnant at this time'. A Twitter poll targeting reproductive medicine clinicians found 45.5 percent support for delaying frozen embryo replacement in patients in areas with a high COVID-19 burden.

The question then arises, for how long should treatment be delayed? It is reported that the UK will see the peak of infections three months from now, with a tail persisting into the autumn and a potential second peak after this. If we were to delay all fertility treatment, UK clinics may struggle with the capacity to cope with demand when treatments re-start. One could easily envisage a delay of six months, which may well harm the chances of conception for some patients. Hence the need for advice to be tailored to each individual patient's situation. Delaying treatment, in effect closing clinics, would have other impacts including financial strain (particularly for smaller stand-alone clinics) and loss of morale among the more vulnerable fertility patients.

Furthermore, Chinese researchers have identified that testicular Leydig cells and seminiferous tubules express the angiotensin-converting enzyme 2 (ACE2) receptor, which is used by the virus to gain entry into cells. This short discussion paper has not been peer-reviewed and there is no evidence to suggest that the virus is found in the testes, as reported in BioNews 1039. However, this paper does alert to the need for further research into whether male fertility may be affected by COVID-19, so that patients can be adequately counselled.

The fact is that this is a fast-moving situation, with facts and knowledge changing daily. This makes it hard for professional bodies to issue meaningful guidance to practitioners and patients. The American Society for Reproductive Medicine even calls its guidance 'suggestions', showing the tentative nature of such advice. As far as UK clinics are concerned, unless restriction of movement is introduced, it is reasonable to continue treatment for those who are well and wish to continue. However, centres must be prepared to terminate or complete treatment (including through cycle cancellation, oocyte or embryo freezing) and cease initiating new treatments as and when 'lock-down' commences.

Clinicians have in their toolbox measures, which can be taken proactively, to reduce the risk to patients who find themselves in a situation where treatment has to stop. A patient may develop symptoms, or fall into a risk group, for COVID-19 after having started ovarian stimulation. Patients on a g onadotropin-releasing hormone (GnRH) antagonist regime could be managed by stopping follicle-stimulating hormone (FSH) administration and continuing antagonist administration until the patient's ovarian response has settled. Data from small case studies indicate that GnRH antagonist continuation after the trigger of final oocyte maturation is effective in reducing the risk of ovarian hyperstimulation syndrome (OHSS). Where concern exists about a high ovarian reserve, consideration should be given to co-treatment with letrozole, keeping oestradiol levels low and reducing concern about the risk of OHSS.

The key is anticipation of problems, both clinical and organisational. All centres should have a contingency plan in place that describes a stepwise reduction in their activities. This allows prioritisation down to a minimal activity if needed. It is unlikely that any licensed fertility clinic can shut down completely; work goes on behind the scenes, in particular around the maintenance of storage banks. There are practical considerations for this maintaining tanks for example but also the regulatory issues around consent expiry and data management. Urgent medical issues will still arise, and it may be appropriate to maintain a fertility preservation service for cancer patients. This prioritisation must take into account national and local pandemic policies, as well as recognition of likely reduced levels of staffing due to illness and isolation. Mitigation policies may include replacing consultations with phone- or video-calls and making sure there is a good communication policy for patients who have treatment-related problems.

We must also bear in mind the anxiety that is generated by how this pandemic is playing out. In our connected world, news, including fake news, travels faster than the virus. It is hard to escape the sense of a storm looming or a tidal wave about to break. In some countries, of course, the storm is now raging and the tide has overwhelmed even well-resourced health systems.

Fittingly for the first pandemic of the social media age, there have been extensive informal discussions on these issues among clinicians across many social media platforms. US colleagues have collated a number of measures, gleaned from social media, that clinics should consider in their response to this challenge.

Things are moving apace, and we must respond in a safe and effective way, but without panic. The British Fertility Society and the Association of Reproductive Clinical Scientists are committed to providing guidance to UK clinics as the situation evolves.

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Keep calm and... stop? Fertility treatment in a pandemic - BioNews