Science Daily | Decoding the genome's cryptic language: New tool to map RNA ... Science Daily Bioengineers have developed a new tool to identify RNA-DNA interactions. The tool can provide a full account of all the RNA molecules that interact with a ... |
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Decoding the genome's cryptic language: New tool to map RNA ... - Science Daily
SINGAPORE Researchers here have come up with a new way to test a patients reaction to a drug even before it is administered.
By first testing a drug on stem cells made from from the patients blood, scientists from the Institute of Bioengineering and Nanotechnology (IBN) of A*STAR and the National Cancer Centre Singapore (NCCS) have found that doctors may screen for possible side effects to drugs..
This, the IBN said, can help create personalised medicine for every individual and improve healthcare and treatment outcome.
Revealing its research findings on Tuesday (Feb 28), A*STAR said it had tested this concept on five kidney cancer patients who had previously been exposed to the cancer drug pazopanib.
Based on their medical history, three of the five patients had displayed adverse reactions to pazopanib in the past.
The researchers used stem cells from the five patients to create liver cells that were then exposed to pazopanib. The study found that the effects of pazopanib on the newly created liver cells tallied with how each of them had previously reacted to the drug.
Furthermore, for those who suffered adverse reactions, the researchers were also able to analyse how pazopanib caused liver damage to them, which was previously unknown to doctors even after many years of using the drug.
This study is the first proof-of-concept that our approach can predict drug-induced liver damage for an individual, said principal research scientist Dr Tan Min-Han. Now that we know how the drug work, we can introduce another agent/drug to combat the side effect. Its like selecting the correct antidote. Thats the next step, to be tested in clinical trials at NCCS.
Fellow researcher Dr Ravindran Kanesvaran said: We are very excited that this study demonstrates an approach that could transform how drug toxicities are evaluated. It also sheds light on the mechanism of a particular side effect of pazopanib, which may lead to ways to overcome it.
The research team said it will conduct further studies on drugs that affect other types of organs, and hope to work with industry partners to commercialise the technology.
IBNs executive director Jackie Y Ying said: Adverse side effects from drugs are a major clinical concern, which could and should be preventable... We are confident that our personalised stem cell technology will be of significant clinical value, said.
According to a study published in 2016, 8.1 per cent of all hospital admissions in Singapore are caused by adverse drug reactions. The study also found that patients suffering from adverse drug reactions also tend to be hospitalised longer than others, while the most common drugs causing adverse reactions were cardiovascular drugs.
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Singapore researchers devise way to test potential drug side effects using stem cells - TODAYonline
Currently, there is no cure or vaccine that provides immunity against SARS-CoV-2. Scientists, however, are still on the hunt to find the best treatments for the disease, says anarticle.
Currently, the broad approaches that scientists are trying to study include antibodies, malaria drugs, and, of course, a vaccine.
Another approach being looked at by scientists is the harvesting of antibodies from the blood plasma of people who survived the illness.
However, this approach is a slow process, and there is no assurance that it can work. Also, there is a need to recruit former patients of the illness to donate plasma.
Then, the next step is to process that plasma and transform it to be used therapeutically.
According to one of the Netflix documentary 'Pandemic: How to Prevent an Outbreak' researcher, Doctor Jacob Glanville, he believes that he had found a shortcut.
Doctor Glanville is the leader of Distributed Bio, a computational immune engineering organization that centers on creating antibody therapeutics and vaccines. For weeks, Glanville and his team had spent a lot of time on their laboratory to engineer a potential treatment for COVID-19.
On April 1, he announced through social media that their team had made a breakthrough.
He revealed that in the last nine weeks, his team had been working had to create an antibody therapy to neutralize and cure COVID-19 patients.
Antibodies are proteins produced by a person's immune system. It helps the body fight against intruders and pathogens, such as the novel coronavirus. It helps keep a person from getting sick.
According to Doctor Glanville, his team had engineered specific antibodies that are good at the task of blocking the deadly novel coronavirus.
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Answers from the Past
Doctor Glanville shared that to save time and get immediate results, he looked back at the antibodies that were proven to be effective at fighting the 2003 SARS virus.
According to Glanville, the 2003 SARS virus is related to the novel coronavirus. It is why his team studied the antibodies that bound SARS. The antibodies are known to have the ability to neutralize the SARS virus. This means that those antibodies will be useful medicine if the2003 SARS viruscame back, the doctor added.
Distributed Bio was able to locate five SARS antibodies successfully. Theseantibodieswere then modified to allow it to bind to receptors of the novel coronavirus.
According to Doctor Glanville, the 2003 SARS virus antibodies were capable of cross-neutralizing antibodies.
The concept used is that the modified antibodies can attach themselves to receptors of the novel coronavirus. This helps prevent the SARS-CoV-2 from invading and infecting healthy human cells.
The COVID-19 treatment that Doctor Glanville and his team are proposing is not a vaccine. According to a coronavirus expert Doctor Anthony Fauci, the discovery of Glanville and his team will become a "game-changer" for a virus that may make a return.
Doctor Glanville and his team's research is similar to the COVID-19 convalescent plasma, which is currently under testing status.
Tagsbioengineering, COVID-19 cure, COVID-19 Treatment, 2003 SARS Virus Antibodies
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Synthetic Antibodies: Bioengineering 2003 SARS Virus Antibodies to Provide Immunity to COVID-19 - Latin Post
Screening and obtaining a novel high activity cellulase and its producing microbe strain is the most important and essential way to improve the utilization of crop straw. In this paper, we devoted our efforts to isolating a novel microbe strain which could produce high activity cellulase. A novel strain Trichoderma virens ZY-01 was isolated from a cropland where straw is rich and decomposed, by using the soil dilution plate method with cellulose and Congo red. The strain has been licensed with a patent numbered ZL 201210295819.6. The cellulase activity in the cultivation broth could reach up to 7.4 IU/mL at a non-optimized fermentation condition with the newly isolated T. virens ZY-01. The cellulase was separated and purified from the T. virens culture broth through (NH4)2SO4 fractional precipitation, anion-exchange chromatography and gel filtration chromatography. With the separation process, the CMC specific activity increased from 0.88 IU/mg to 31.5 IU/mg with 35.8 purification fold and 47.04% yield. Furthermore, the enzymatic properties of the cellulase were investigated. The optimum temperature and pH is 50 C and pH 5.0 and it has good thermal stability. Zn2+, Ca2+ and Mn2+ could remarkably promote the enzyme activity. Conversely, Cu2+ and Co2+ could inhibit the enzymatic activity. This work provides a new highly efficient T. virens strain for cellulase production and shows good prospects in practical application. Full article
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Bioengineering | An Open Access Journal from MDPI
The Columbus Idea Foundry provides a glimpse of the future of manufacturing. The Idea Foundry is an expression of the maker movement, a renewed interest in things and objects, in making and manufacture, and in the skilled trades, which have been in decline over the past two generations.
Manufacturing at the Idea Foundry is smaller scale, based on batch processing, and on customizable, bespoke goods, not on the model of a giant factory with thousands of workers. In many ways, the Idea Foundry is a post-industrial enterprise that harkens back to pre-industrial patterns of manufacturing.
Where students now study computer science or software design, we could begin to see college students take the route toward manufacturing and making. That route, however, will not be the one that existed in the U.S. in the 1950s, where an 18-year old might graduate high school and the next day begin work in a factory. Todays manufacturing is hi-tech: look at the 3-D printers and other technologies found at the Idea Foundry. To operate such tools requires advanced skills.
The Massachusetts Department of Higher Education is already looking ahead to the workforce development needs for this advanced manufacturing. They announced their Advanced Manufacturing Workforce Plan in the Spring of 2015, which stated that [We must] look beyond the requirements of todays advanced manufacturing workforce to new and possibly higher-level competencies that will be required of the next generation workforce. While the current focus of workforce demand is centered on todays definition of the production manufacturing worker, accelerating advances in materials, technologies and supply chain processes will require a workforce with substantially new and different knowledge, skills and abilities to build the products of the future.
This means that four-year universities, not only technical and community colleges, must be geared up to train workers in advanced manufacturing skills.
As a measure of the high tech nature of manufacturing, much of what occurs in a factory is done by robots, machines and other forms of automation. Fewer workers monitor the technology that actually does the manufacturing.
Automation has always been the driving force in manufacturing after the Industrial Revolution: the historical trajectory has been the substitution of machines (capital) for human labor, and there is every reason to believe that long-term trend will continue unabated.
According to a McKinsey report, some 59 percent of all manufacturing activities could be automated, given technical considerationsWithin manufacturing, 90 percent of what welders, cutters, solderers, and brazers do, for example, has the technical potential for automation.
Returning manufacturing jobs from China and Mexico was a central feature of the Trump campaign, and indeed the President has taken some executive actions to reverse this and to bring some of these manufacturing jobs back to the U.S. But many economists have noted that job loss in manufacturing has been less the result of overseas outsourcing as it has from automation.
It is possible that President Trump will realize this reality, and if he remains committed to restoring manufacturing jobs, he might begin to institute policies to regulate automation. Might Trump insist that manufacturing be conducted by human laborers, else the companies using robots and other such technologies will be subject to taxes or other forms of retribution? Might consumers also begin to demand that the products they buy not only be Made in the USA but also Made by Human Hands? I think these are unlikely scenarios: it has been a truism of the Industrial Revolution that machines replace human labor, and I see no real challenge to that economic logic. But by the same token, some consumers have been demanding that foodstuffs not contain GMOs, and so it is possible that a similar sort of grass roots rejection of automated-manufactured goods could emerge.
We have long associated manufacturing with mechanical things: the production of automobiles, consumer goods, industrial materials. There is every reason to believe that the next phase of the Industrial Revolution will involve not only mechanical things but also the manufacture of biological objects.
Bioprinting is still in the experimental stage, but the technology promises the ability to print out living tissue, even human organs, through a process similar to the 3-D printers. Rather than printing off plastic objects, bioprinting involves spraying layer upon layer of cells in a manner similar to an ink-jet printer, thereby additively manufacturing living organs.
The initial uses for such biological objects will be for organic matter that will be used for drug testing. Rather than using lab animals, living human organsmanufactured organscan be tested instead. Some experiments have already produced manufactured arteries, and very soon manufactured liver cells might be injected into patients who are suffering from liver disease.
Ultimately, the goal is to be able to print an entirely new liver for a patient in need of a replacement. To work in this form of biological manufacturing will require advanced degrees in biology, chemistry and biological engineering.
All of this is by way of saying that manufacturing jobs in the future might just as likely involve the production of living, squishy, pulsating biological objects.
David Staley is president of Columbus Futuristsand a professor of history, design and educational studies at The Ohio State University. He is the host of CreativeMornings Columbus.
The next Columbus Futurists monthly forum will beThursday February 23 at 6:30 PMat the Panera Bread community room (875 Betel Rd.) Our topic for the evening will be Blockchain and the Future of the Internet.
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NEXT: The Future of Manufacturing will be Driven by Automation and Bioengineering - columbusunderground
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A prominent university in Texas has developed an inexpensive, automatic and hand-held ventilator that could soon be available to doctors in the US and help them combat the coronavirus pandemic that has infected over 164,000 people and claimed the lives of 3,170 others in the country. Across the United States, hospitals are facing shortages of ventilators, some medical device makers have agreed to ramp up supplies. But because patients diagnosed with or suspected to have COVID-19 often require breathing support, there is widespread concern that these devices won''t be developed and shipped quickly enough.
Texas-based Rice University and Canadian global health design firm Metric Technologies have developed an automated bag valve mask ventilation unit that can be built for less than USD 300 worth of parts and help patients undergoing treatment for COVID-19. The collaboration expects to share the plans for the ventilator by making them freely available online to anyone in the world. The varsity team designed and built a programmable device able to squeeze a bag valve mask. These masks are typically carried by emergency medical personnel to help get air into the lungs of people having difficulty breathing on their own. But the masks are difficult to squeeze by hand for more than a few minutes at a time.
"It's automatic, electric, and works independently of a tech," Wettergreen, a varsity professor and member of the Design Kitchen team, told PTI. "It's not designed for people who are critical cases, but rather who are in respiratory distress," the professor said. That delineation is important: the automated Bag Mask Valve (BVM) would take less-critical patients off ventilators and free them up for only those in dire need. The benefit could be a game changer for those on the front lines of the COVID-19 battle, Wettergreen said.
"When a crisis hits, we use our skills to contribute solutions. If you can help, you should, and I''m proud that were responding to the call," said the professor. The design has caught the attention of the Department of Defense, which may authorise the Navy to utilise it in the near future. It's a huge feat for the small unit, dubbed the Apollo BVM team, whose students worked around the clock and took classes online in order to deliver the project as soon as possible.
Rohith Malya - an assistant professor of emergency medicine at Baylor College of Medicine, an adjunct assistant professor of bioengineering at Rice, and a principal at Metric Technologies - coined the name as a tribute to Rice''s history with NASA and former US President John F Kennedy''s now-famous speech kicking off the nation''s efforts to go to the moon.
"This project appeals to our ingenuity, it's a Rice-based project and it's for all of humanity. And we''re on an urgent timescale. We decided to throw it all on the table and see how far we go," he said. Malya inspired the Rice project two years ago after seeing families try to keep critically ill loved ones at the Kwai River Christian Hospital in Thailand alive by bag-ventilating them for hours on end.
He expects the new Apollo BVM to serve that purpose eventually, but the need is now worldwide. "This is a clinician-informed end-to-end design that repurposes the existing BVM global inventory toward widespread and safe access to mechanical ventilation," Malya said, noting that more than 100 million bag valve masks are manufactured around the world each year.
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US-Based University Develops Hand-Held, Automatic Ventilators To Fight Coronavirus - News Nation
Financing will support i20 Therapeutics growth and R&D of platform for oral delivery of injectable biologic drugs
i2O Therapeutics, an innovative biotech company developing a platform for oral delivery of traditionally injectable biological drugs, announced today it has raised a $4 million seed funding round led by Sanofi Ventures and JDRF T1D Fund.
Founded by a team of researchers from Harvard University, i2O Therapeutics is focused on the development of safe and effective oral formulations of therapies that are conventionally limited to injections, e.g. biologics, large molecules, and peptide-based pharmaceuticals such as insulin. The foundational technology has been exclusively licensed to i2O by Harvards Office of Technology Development. The companys innovative platform enables drugs that traditionally wouldnt survive the hostile environment of the digestive system to pass through safely by utilizing a unique coating that dissolves in the small intestine, thereby releasing the active drug. I2Os initial focus is on developing a novel oral formulation for GLP-1 analogs.
The technology was initially developed in the Harvard lab of Samir Mitragotri, PhD, who is Hiller Professor of Bioengineering and Hansjorg Wyss Professor of Biologically Inspired Engineering at Harvard John A. Paulson School of Engineering and Applied Sciences and a Core Faculty member at Harvards Wyss Institute for Biologically Inspired Engineering.
"Our technology has the potential to enable the oral delivery of high-value drugs in a safer, more effective and patient-friendly way and also by easing the treatment burden for dozens of therapeutics that were previously restricted to intravenous or subcutaneous delivery," commented Mitragotri, Co-founder of i2O Therapeutics.
"The support and partnership of Sanofi Ventures and JDRF T1D Fund marks a major milestone for i2O, and potentially millions of people around the world. This round of financing will enable us to rapidly expand our team and ramp up research and development at i2O as we seek to create the next generation of oral peptide and protein-based therapies," commented Ravi Srinivasan, PhD, Co-founder of i2O Therapeutics.
"i2O Therapeutics is developing an extremely promising new platform for oral biologics with the potential to significantly ease treatment burden for countless patients who rely on drugs that can only be administered via injection," said Christopher Gagliardi, PhD, Director of Investments at Sanofi Ventures.
"We are excited to partner with i2O Therapeutics, whose platform has the potential to revolutionize the way people with diabetes manage their disease," commented Katie Ellias, Managing Director of the JDRF T1D Fund. "The possibility of an oral insulin product, among other exciting applications of the i2O platform, represents a significant commercial opportunity and more importantly, has the potential to improve glycemic management and decrease hypoglycemia risk over todays injectable insulins."
Both Christopher Gagliardi and Katie Ellias will join the i2O Board of Directors.
About i2O Therapeutics
i2O Therapeutics is a biotechnology company developing safe and effective oral formulations of therapies traditionally limited to injections. Using an innovative ionic liquid technology, this platform leverages the benefits of protecting the drug cargo while also transiently enhancing permeation across the epithelial lining when administered orally. i2O is focused on creating the next generation of oral peptide and protein-based therapies. Visit us at http://www.i2OBio.com.
About JDRF T1D Fund
The JDRF T1D Fund (https://t1dfund.org/) is a venture philanthropy fund accelerating life-changing solutions to cure, prevent and treat type 1 diabetes (T1D) through catalytic equity investments. Through its investments in partnership with private capital, including venture capital, corporations and foundations, the T1D Fund seeks to attract the private investment necessary to advance therapeutics, devices, diagnostics, and vaccines into the hands of those living with T1D. The T1D Fund invests in areas strategically aligned with JDRF, the leading global organization funding T1D research, with an exclusive focus on supporting the best commercial opportunities. The T1D Fund reinvests any realized gains into new investments to further its mission.
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About Sanofi Ventures
Sanofi Ventures is the corporate venture capital arm of Sanofi. Sanofi Ventures invests in early-stage biotech and digital health companies with innovative ideas and transformative new products and technologies of strategic interest to Sanofi. Among these areas are oncology, immunology, rare diseases, vaccines, potential cures in other core areas of Sanofis business footprint, and digital health solutions. For more information, visit http://www.sanofiventures.com.
View source version on businesswire.com: https://www.businesswire.com/news/home/20200409005121/en/
Contacts
Gregory Johnson, PhDMacDougallGjohnson@macbiocom.com
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i2O Therapeutics Raises $4 million in Seed Funding Co-led by Sanofi Ventures and JDRF T1D Fund - Yahoo Finance
The Bioreactors and Fermentors market report will provide one with overall market analysis, statistics, and every minute data relating to the Bioreactors and Fermentors market necessary for forecasting its revenue, factors propelling & hampering its growth, key market players [Bioengineering AG, Applikon Biotechnology, Pall Corporation, GE Healthcare, Sartorius AG, Eppendorf, Thermo Fisher Scientific, Cellexus, Celltainer Biotech BV, Finesse Solutions, Merck Millipore, PBS Biotech, Cellution Biotech, CerCell ApS, Electrolab Biotech, Infors AG, Pierre Guerin, Techniserv, Broadley-Jamesn], and much more. In addition, the key focus points of the report are services, analytics, billings, management, and system.
The report offers a statistical analysis of every market aspect that would assist our clients in outlining business strategies and decision-making. Further, it will also aid them to jot down the future interest and accordingly execute their plans.
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The Bioreactors and Fermentors market report entails a market synopsis and offers definition & outline of the Bioreactors and Fermentors market. The information provided in the report cover over-the-board data such as market trends, drivers, restraints, opportunities, market shares, challenges, economy, supply chain, and finance in addition to specifics such as software, and communication. Furthermore, the Bioreactors and Fermentors market is categorized based application, end-user, technology, the types of product/service, and others, as well as regions. Additionally, the report encompasses the computed expected CAGR of the Bioreactors and Fermentors market derived from previous records about the Bioreactors and Fermentors market and existing market trends together with future developments. The report also highlights other market factors like consumption, asset tracking, and security. To summarize, the report entails: Overall market summary Growth factors (drivers & restraints) Segmentation Regional analysis Revenue Market players Latest trends and opportunities
The team here entails proficient market researchers, knowledgeable consultants, and trustworthy data providers. The team employs proprietary data resources and a number of tools and methods such as NEST, PESTLE, Porters Five Forces, and so on to collect and evaluate the market statistics and other relevant data. Also, the team works round the clock to incessantly update and revise the market data in order to mirror the up-to-the-minute data and trends.
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All in allTo conclude, the Bioreactors and Fermentors market report will provide the clients with a high-yielding market analysis assisting them to understand the market status and come up with new market avenues to capture hold of the market share.
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Global Bioreactors and Fermentors Market Factors Impacting Future Performance 2019: Bioengineering AG, Applikon Biotechnology, Pall Corporation, GE...
Scientists at the School of Chemistry, Trinity College Dublin and AMBER, the SFI Research Centre for Advanced Materials and Bioengineering Research think so
Scientists at the School of Chemistry, Trinity College Dublin and AMBER, the SFI Research Centre for Advanced Materials and Bioengineering Research think so.
Unlike current fossil fuel based energy production systems fuel cells offer a clean and efficient way to generate electricity with water and heat the only waste products.
The drawback? Current fuel cell technology relies on high value and scarce metals such as platinum to act as a catalyst and speed up reactions in the fuel cell.
If such metals can be removed from the process, the potential for fuel cells to form part of the solution to climate change and energy storage challenges are impressive, as they could provide power for large and small scale systems from power stations to laptop computers.
Scientists have long looked at the potential for carbon nanostructures to take the place of platinum, and other metals, in fuel cells, while maintaining performance.
In the journal SMALL a team from Trinity College and AMBER led by Prof Paula Colavita and Prof Max Garca-Melchor have provided a roadmap for carbon material design to enable the next generation of metal-free fuel cell catalysts.
Speaking about the research, which features on the front cover of the SMALL, Prof Colavita said: Our findings offer a new vision of cooperativity among different properties of carbon materials that must be met to lower the cost of fuel cells.
Together with Prof Garcia-Melchor, we have identified important design principles for the next generation of smart carbons to enable an expansion of technologies based on renewables sources.
Prof Garca-Melchor said: We believe these new insights may open up new avenues to leverage synergistic effects improving performance and allowing us to push the limits of carbon nanomaterials to outperform the state-of-the-art catalysts based on precious metals.
The research was conducted by the School of Chemistry, Trinity College Dublin, in conjunction with School of Physics, Department of Electronic and Electrical Engineering, Trinity College Dublin, and the Faculty of Physics, University of Bucharest, Romania.
Scientists at the School of Chemistry, Trinity College Dublin and AMBER, the SFI Research Centre for Advanced Materials and Bioengineering Research think so.Unlike current fossil fuel based energy production systems fuel cells offer a clean and efficient way to generate electricity with water and heat the only waste...
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Could the future of energy production be nano-enabled fuel cells? - Engineers Journal
The recent study on Vertical Garden Construction Market Share | Industry Segment by Applications (Residential and Commercial), by Type (Indoor Vertical Garden Wall and Outdoor Vertical Garden Wall), Regional Outlook, Market Demand, Latest Trends, Vertical Garden Construction Industry Growth & Revenue by Manufacturers, Company Profiles, Growth Forecasts 2025. Analyzes current market size and upcoming 5 years growth of this industry.
There are a number of insights are included or analyzed in this market study which is helpful in devising strategies for the future and take necessary steps. New project investment feasibility analysis and SWOT analysis are offered along with insights on industry barriers.
The market study also explains the key market players, especially the wholesalers, distributors, businesspersons along with the industrial chain structure. The development of market trends is considered along with the competitive landscape in various regions, countries, provinces which would boost top and arising market players to discover the lucrative investment pockets.
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The major market players operating in the industry are:
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BOCA RATON, Fla., Nov. 23, 2019 /PRNewswire/ --Florida Atlantic University faculty, staff and students came together with local officials and community partners today to celebrate the 20th anniversary of FAU's John D. MacArthur Campus at Jupiter with a ceremonial groundbreaking for the new FAU Neuroscience Building and a new residence hall.
"I can't think of a better way to commemorate the 20th anniversary of our Jupiter campus than with a celebration marking the construction of two new state-of-the-art buildings," said FAU President John Kelly. "Our Jupiter campus is the only place on earth where Scripps and Max Planck sit next to each other, and FAU is working to ensure this incredible synergy is leveraged to create a unique learning laboratory where exemplary students can shine."
The university will construct the 58,000-square-foot FAU Neuroscience Building to enhance collaborative research with Scripps Research and Max Planck Florida Institute for Neuroscience (MPFI). The building will increase shared research and office space for new STEM faculty and provide the additional teaching and instructional space needed to support projected enrollment growth, especially in specific areas such as neuroscience, biotechnology, bioengineering, bioinformatics/data science and chemistry. The structure will also support increasing FAU intellectual property licensing activity and "spinout" companies. The $35 million transformative research space represents a significant investment by the state of Florida, FAU and its research partners. Construction is expected to start in the summer of 2020.
The $17.1 million, 165-bed residence hall will provide a total of 435 beds for the Jupiter campus that is currently at max capacity. Construction will begin in spring 2020 with completion set for summer 2021. Residential students living in the new hall will enjoy a fitness area, study rooms, laundry on each floor, computer lab and a rooftop patio.
These two new structures build on FAU's aggressive moves to ramp up its research footprint and academic offerings at the Jupiter campus. In November 2018, FAU expanded on existing graduate and undergraduate opportunities with the announcement of the FAU-Max Planck Academy, the only academic program in the world that will allow the brightest STEM high school students to work side-by-side with preeminent scientists at one of the world's leading neuroscience research institutions. FAU, MPFI and the Germany-based Max Planck Society will welcome the academy's first class in the fall 2020 semester.
"I am incredibly proud of the strides that FAU and the world-class research institutes located on its campus have made in building a robust life science ecosystem in Palm Beach County," said State Rep. MaryLynn Magar. "I am honored to carry that message to Tallahassee and encourage my fellow legislators to continue the state's investment in the unprecedented educational programs and groundbreaking research partnerships that are taking place here in Jupiter."
Other 20th anniversary celebratory events include a ribbon cutting on May 11, 2020 when FAU and MPFI officials open the FAU-Max Planck Academy building.
Named after businessman and philanthropist John D. MacArthur, FAU's Jupiter campus opened on 135 acres of land donated by the John D. and Catherine T. MacArthur Foundation in the fall of 1999. The campus established the nationally ranked Harriet L. Wilkes Honors College, the first public honors institution to be built from the ground up in the United States. FAU's Jupiter campus was built into the master plan of the Abacoa community to help engage local residents and to serve the people of Palm Beach and Martin counties. In 2005, FAU welcomed Scripps Research faculty and staff to its Jupiter campus and a groundbreaking for the MPFI building was held in 2010.
In addition to being home to Scripps Research and MPFI, FAU Jupiter is home to the faculty labs of the Charles E. Schmidt College of Science. Recognized as a center of scientific activity, the campus also serves as the headquarters for two of FAU's primary research organizations, the Brain Institute and the Institute for Human Health and Disease Intervention (I-HEALTH). The College of Education also hosts the Academy for Community Inclusion and the community-centered Center for Autism and Related Disabilities (CARD) program on the Jupiter campus. The Osher Lifelong Learning Institute, housed in the Elinor Bernon Rosenthal Lifelong Learning Complex on the Jupiter campus, is the largest membership organization of its kind in the country delivering personal enrichment courses covering a broad range of stimulating topics that are taught by leading experts.
- FAU -
About Florida Atlantic University:Florida Atlantic University, established in 1961, officially opened its doors in 1964 as the fifth public university in Florida. Today, the University, with an annual economic impact of $6.3 billion, serves more than 30,000 undergraduate and graduate students at sites throughout its six-county service region in southeast Florida. FAU's world-class teaching and research faculty serves students through 10 colleges: the Dorothy F. Schmidt College of Arts and Letters, the College of Business, the College for Design and Social Inquiry, the College of Education, the College of Engineering and Computer Science, the Graduate College, the Harriet L. Wilkes Honors College, the Charles E. Schmidt College of Medicine, the Christine E. Lynn College of Nursing and the Charles E. Schmidt College of Science. FAU is ranked as a High Research Activity institution by the Carnegie Foundation for the Advancement of Teaching. The University is placing special focus on the rapid development of critical areas that form the basis of its strategic plan: Healthy aging, biotech, coastal and marine issues, neuroscience, regenerative medicine, informatics, lifespan and the environment. These areas provide opportunities for faculty and students to build upon FAU's existing strengths in research and scholarship. For more information, visit http://www.fau.edu.
This news release was issued on behalf of Newswise. For more information, visit http://www.newswise.com.
Media Contacts: Lynda Rysavy LFigueredo@fau.edu Phone: 561-475-0960
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Groundbreaking for Neuroscience Building and Residence Hall Mark 20th Anniversary Of FAU's John D. MacArthur Campus - P&T Community
The University of California San Siego (UCSD) has formed the San Diego Institute for Materials Discovery and Design, a joint initiative of the Jacobs School of Engineering and Division of Physical Sciences at UCSD. Shirley Meng, Zable Professor of NanoEngineering, will serve as director of the Institute; Michael Sailor, Distinguished Professor of Chemistry and Biochemistry, will serve as co-director.
The institutions goal is to position UC San Diego as the recognized global academic leader in nanoscale and quantum materials design and discovery. The Institute will apply data analytics and machine learning together with rapid materials synthesis and multi-scale characterization in order to accelerate the discovery, design, synthesis and evaluation of novel functional materials. Application areas include energy systems, electronics, information technology, telecommunications, space systems and medicine.
The Institute will build on UC San Diego resources such as the Nano3 Facility and the San Diego Supercomputer Center. In addition, the campus-wide Materials Science and Engineering Graduate Program will be an important part of the Institute.
This program, which is administered by the Mechanical and Aerospace Engineering (MAE) Department under the leadership of MAE Professor Prabhakar Bandaru, already includes more than 90 participating faculty from the departments of MAE, Structural Engineering, Bioengineering, Electrical and Computer Engineering, NanoEngineering, Physics, Chemistry and Biochemistry, Scripps Institution of Oceanography, as well as the School of Medicine and Division of Biological Sciences.
The San Diego Institute for Materials Discovery and Design will initially focus on several important initiatives, including:
Deployment of Frontier Instrumentation: The Institute will build up a world-class nanoanalytical instrumentation facility, within the Nano3 facilities in Atkinson Hall. The first acquisition is a state-of-the-art Thermo Fisher Scientific Transmission Electron Microscope (Talos F2001 S/TEM) dedicated to materials characterization. Installation of the TEM is expected to be complete by January 2020.
Contributions to Graduate Education: The Institute aims to develop new training and curricula in data analytics and machine learning applied to materials science and engineering as well as nanoanalytical/nanofabrication training associated with the Nano3 facility. The Institute will also work towards establishing new graduate fellowships in materials science through collaboration with industry, foundation and community partners.
Multi-Investigator Grants: As the Institute builds up the campus research instrumentation capability, UC San Diego will be better positioned to compete for large multi-investigator materials research center awards. Several joint proposals are already under development or have been submitted.
Distinguished Seminar Series: The Institute will host a distinguished seminar series aimed at catalyzing new collaborations while raising UC San Diegos national profile and international stature.
See more here:
UC San Diego launches Institute for Materials Discovery and Design - Green Car Congress
NEW YORK, Oct. 30, 2019 /PRNewswire/ --
Fermenters Market by Process (Batch Fermentation, Continuous Fermentation, and Others), Application (Food, Beverage, Healthcare & Personal Care, and Others), and Mode of Operation (Semi-automatic and Automatic): Global Opportunity Analysis and Industry Forecast, 2018 - 2025
Read the full report: https://www.reportlinker.com/p05793234/?utm_source=PRN
The global fermenters market was valued at $1,135.5 million in 2017, and is projected to reach $1,781.3 million by 2025, growing at a CAGR of 5.7% from 2018 to 2025
Fermenters are complex vessels designed to maintain optimum environmental conditions for the growth of microorganisms. Fermenters are cylinder shaped containers in which biological processes are carried out under controlled environment. They are designed to bear high pressure and temperature conditions mediated by the fermentation medium. Furthermore, they are available in different shapes and sizes ranging from a few milliliters to thousands of liters. They are used in a variety of end-use industries from food to pharmaceuticals, from cosmetics and personal care to biofuels.
The key factors that drive the growth of the global fermenters market include increase in technological innovations and rise in demand for fermenters in the pharmaceutical and alcohol industries. Moreover, customized solutions according to specific requirements and designs have created new opportunities for the market growth. However, factors such as high price of fermenters and difficulty in optimization and integration of large-scale fermenters are expected to impede the overall market growth. Furthermore, novel innovations for fermenters such as automation, miniaturization, and customization have gained huge traction in the recent years, which in turn are anticipated to create lucrative opportunities for the market growth in the future.
The global fermenters industry is segmented into process, application, mode of operation, and region. Based on process, the market is divided into batch fermentation, continuous fermentation, and others. The applications covered in the study include food, beverage, healthcare & personal care, and others. Depending on mode of operation, the market is bifurcated into semi-automatic and automatic. Region wise, it is analyzed across North America (U.S., Canada, and Mexico), Europe (UK, Germany, France, Spain, Italy, and rest of Europe ), Asia-Pacific (China, Japan, India, Australia, South Korea, and rest of Asia-Pacific ), and LAMEA (Latin America, Middle East, and Africa )
Key players profiled in the report include Eppendorf AG, Sartorius AG, Thermo Fisher Scientific Inc., GEA Group Aktiengesellschaft, General Electric Company, PIERRE GUERIN SAS, CerCell ApS, Electrolab Biotech Ltd, Applikon Biotechnology BV, Bioengineering AG, ZETA Holding GmbH, and BBI-Biotech GmbH
KEY BENEFITS FOR STAKEHOLDERS The report provides an extensive analysis of the current and emerging market trends and opportunities in the global fermenters market. The report provides detailed qualitative and quantitative analysis of current trends and future estimations that help evaluate the prevailing market opportunities. A comprehensive analysis of the factors that drive and restrict the growth of the market is provided. An extensive analysis of the market is conducted by following key product positioning and monitoring the top competitors within the market framework. The report provides extensive qualitative insights on the potential and niche segments or regions exhibiting favorable growth.
KEY MARKET SEGMENTS
By Process Batch Fermentation Continuous Fermentation Others
By Application Food Beverage Healthcare & Personal Care Others
By Mode of Operation Semi-automatic Automatic
By Region North America o U.S. o Canada o Mexico Europe o UK o Germany o France o Spain o Italy o Rest of Europe Asia-Pacific o China o Japan o India o Australia o South Korea o Rest of Asia-Pacific LAMEA o Latin America o Middle East o Africa
Read the full report: https://www.reportlinker.com/p05793234/?utm_source=PRN
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The global fermenters market was valued at $1,135.5 million in 2017, and is projected to reach $1,781.3 million by 2025, growing at a CAGR of 5.7%...
The Global Capsule Filters Market report provides information by Top Players, Geography, End users, Applications, Competitor analysis, Sales, Revenue, Price, Gross Margin, Market Share, Import-Export, Trends and Forecast.
Initially, the report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure. The Capsule Filters market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status.
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Global Capsule Filters market competition by top manufacturers, with production, price, revenue (value) and market share for each manufacturer.
Major players profiled in the report are Amazon Filters Ltd, Amiad Water Systems, BEA Technologies, Critical Process Filtration, Entegris, Hangzhou Tailin Bioengineering Equipments, JURA FILTRATION, KITZ MICRO FILTER CORPORATION, Merck Millipore, MITA Biorulli, Outotec, PALL, Sartorius AG, Thermo Scientific, Whatman, Wolftechnik Filtersysteme.
On the basis of products, report split into, Capsule Filters.
On the basis of the end users/applications, this report focuses on the status and outlook for major applications/end users, consumption (sales), market share and growth rate for each application, including Final Product Processing, Small Molecule Processing, Biologics Processing, Cell Clarification, Raw Material Filtration, Media and Buffer Filtration, Bioburden Testing.
The report introduces Capsule Filters basic information including definition, classification, application, industry chain structure, industry overview, policy analysis, and news analysis. Insightful predictions for the Capsule Filters market for the coming few years have also been included in the report.
Development policies and plans are discussed as well as manufacturing processes and cost structures are also analyzed. This report also states import/export consumption, supply and demand Figures, cost, price, revenue and gross margins.
The report focuses on global major leading Capsule Filters Market players providing information such as company profiles, product picture and specification, capacity, production, price, cost, revenue and contact information. Upstream raw materials and equipment and downstream demand analysis is also carried out.
The Capsule Filters industry development trends and marketing channels are analyzed. Finally the feasibility of new investment projects are assessed and overall research conclusions offered.
Table of Contents
1 Capsule Filters Market Overview
2 Global Capsule Filters Market Competition by Manufacturers
3 Global Capsule Filters Capacity, Production, Revenue (Value) by Region (2013-2018)
4 Global Capsule Filters Supply (Production), Consumption, Export, Import by Region (2013-2018)
5 Global Capsule Filters Production, Revenue (Value), Price Trend by Type
6 Global Capsule Filters Market Analysis by Application
7 Global Capsule Filters Manufacturers Profiles/Analysis
8 Capsule Filters Manufacturing Cost Analysis
9 Industrial Chain, Sourcing Strategy and Downstream Buyers
10 Marketing Strategy Analysis, Distributors/Traders
11 Market Effect Factors Analysis
12 Global Capsule Filters Market Forecast (2018-2025)
13 Research Findings and Conclusion
14 Appendix
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News Live 2019: Global Capsule Filterss Market Rise to High Globally In Next Five Years - Maxi Wire
There is no doubt that viral disease transmission is a risk to many countries, one that requires a coordinated international response and a strong scientific basis to feed our understanding of viral outbreaks that cause some of the worst diseases in the world today. There have been dozens of registered alerts in the past decade; for example, in July, the World Health Organization (WHO) declared the current Ebola outbreak in the Congo a public health emergency of international concern, while last year, there was a Nipah Virus encephalitis outbreak in the Kerala state of India, and lets not forget the Zika pandemic of 2016 that caused more than 3,700 children to be born with birth defects.
Global Virus Network Responds to Ebola Outbreak in the Democratic Republic of the Congo (Image credit: GVN)
All these warnings are crucial evidence that our world is immensely interconnected and surprisingly vulnerable. Moreover, researchers and scientists are racing to develop urgent and proactive measures to address the challenges that viruses, including those that are yet unknown, pose to global health and security. To that purpose, theGlobal Virus Network (GVN), which catalyzes collaborative research into diseases caused by every class of virus in humans and animals, announced the addition of the Wyss Institute for Biologically Inspired Engineering at Harvard University as one of its new Centers of Excellence.
Wyss will provide its virus expertise and core technologies, including their human Organ Chips, which they began developing in 2016, along with researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS). The first entirely multi-material 3D printed organ-on-a-chip was a Heart Chip with integrated soft sensors to track the beating tissue. It can be quickly fabricated with customizable size, shape, and other physical properties while allowing researchers to easily collect reliable data for extended times in culture.
At the time, Johan Ulrik Lind, first author of the paper and postdoctoral fellow at SEAS and the Wyss Institute, declared that the new programmable microfabrication approach to building organs-on-chips not only allows us to easily change and customize the design of the system but also drastically simplifies data acquisition.
Organs on chips mimic the structure and function of native tissue and have emerged as a promising alternative to traditional animal testing. For the Heart-on-a-Chip, Harvard experts developed six different inks that integrated soft strain sensors within the microarchitecture of the tissue. In a single, continuous procedure, the team 3D printed those materials into a cardiac microphysiological device.
3D printing has proven very helpful in creating and integrating multiple functional materials within printed devices. But Wyss will also contribute their knowledge on genome engineering, synthetic biology, and immunomaterials, as well as diagnostics capabilities to participate in GVNs collaborative approach to virus detection and therapy.
It is one of six new Institutes to join the GVN as Centers of Excellence and Affiliates, including theManipal Academy of Higher Education, in India; The Tropical Medicine Institute Alexander von Humboldt of the Universidad Peruana Cayetano Heredia; the Korea National Institute of Healths Center for Infectious Diseases Research; the Research Institute of Virology, at the Ministry of Health of the Republic of Uzbekistan; and the Antiviral Pharmacology Laboratory and Clinical Trials Research Center Virology Program at the University of Zimbabwe. The conglomerate already houses 52 centers and nine affiliates in 32 countries and is founded on the principle that preparedness for emerging viral diseases will need deeply rooted collaborative research between local and global partners, and the transformation of diagnostic tools and regional surveillance networks.
The announcement was made in late October by the GVNs President Christian Brchot and Robert Gallo, Co-Founder and Chairman of the International Scientific Leadership Board of the GVN and best known for his role in the discovery of the human immunodeficiency virus (HIV) and in the development of the HIV blood test.
Since HIV/AIDS first appeared, I strongly believed mankind will best be served if the worlds leading virologists are organized and better equipped to deal with existing and new viral threats, said Gallo. These diverse new members of the GVN add depth of expertise and global reach to our network. They will help us better combat viral threats and train the next generation of virologists.
Wyss will help leverage recent insights into how Nature builds, controls and manufactures to develop new engineering innovations, a new field of research that institute researchers are referring to as Biologically Inspired Engineering. They claim that by emulating biological principles of self-assembly, organization, and regulation, Wyss is developing disruptive technology solutions for healthcare, energy, architecture, robotics, and manufacturing, which are translated into commercial products and therapies through the formation of new startups and corporate alliances.
The Institutes uniqueOrgan-on-a-Chip technology enables modeling of human tissues within vivo-like architectures and physiologies to study viral infection, propagation, evolution, patient-to-patient transmission, and host responsesin vitro. Wyss researchers are applying human Organ Chips and a variety of its other core technologies in a highly multi-disciplinary approach to create rapid, sensitive, and highly specific diagnostics for the detection of viruses, broad-spectrum anti-virus vaccines, new antiviral therapeutics, novel drug delivering viral vectors, and culture-free viral infectivity assays.
Organ-on-a-Chip (Image credit: Wyss Institute at Harvard University)
We offer the GVN a truly unique skill set in bioengineering and technology innovation that will nicely complement the more classic virology focus of most other members of the network, as well as numerous powerful enabling technologies that GVN members should find extremely useful. We look forward to the GVN helping us to identify relevant funding opportunities and sources of clinical samples, and to team with us to build stronger consortia around specific problems, and if possible, to provide support for fellows and trainees, confirmed Wyss Founding Director and Professor of Bioengineering at SEAS, Donald Ingber.
Wyss has been at the forefront of bioengineering technology for many years, with two researchers working on a new way to develop 3D printed organs, and a multi-disciplinary team looking to create a functioning kidney subunit with current work to build the branched vascular networks unique to each organ. Its also launching a human Organ Chip project to model influenza virus infection and develop new therapies. Its an exciting time for Wyss and now will become even more challenging as they attempt to solve together with other worldwide institutions some of the most devastating viruses we have ever seen.
Multi-material, direct-write 3D printing of a cardiac microphysiological device, designed for in vitro cardiac tissue research (Image credit: Lori K. Sanders/Harvard University)
The GVN continues to serve as a catalyst uniquely connecting top virus research institutions from around the world to build collaborative, effective alliances and eradicate viral threats. In fact, these six Centers and Affiliates perfectly illustrate the concept of combining Centers with highly complementary skills, from all over the world, said Brchot, who is also Professor at the University of South Florida.
Increasing population mobility across permeable borders coupled with weakened health systems is a terrible combination that can lead to the spread of outbreaks, epidemics, and pandemics. The GVN is recruiting some of the most forward-thinking institutions around the world to provide a defense to the emerging, exiting and unidentified viruses on the planet. Working closely to advance knowledge and provide treatments to combat these deadly viruses is the first line of defense, avoiding outbreaks to go from specifically delimited areas to countries, and beyond. Using some of the most advanced technology, like 3D printing Organ Chips, bioprinting and bioengineering can make a big difference in the way humans target, resolve and treat evolving biological agents.
Discuss this and other 3D printing topics at 3DPrintBoard.com or share your thoughts below.
More:
Wyss Institute will Help Combat Viral Threats with 3D Printed Organ-on-a-Chips - 3DPrint.com
The Biomedical Engineering Society supports students with an interest in the biomedical engineering field.
The biomedical engineering field bridges the gap between engineering and medicine by combining engineering principles and design skills with medical and biological sciences to advance healthcare.
Through BMES, members have the opportunity to learn more about the field, tour local biotech companies and attend bioengineering symposiums.
BMES vice president Nikolas Marquez said the highlight of his time with the organization has been the chance to interact with graduate students, professors and professionals who share his passion for the advancement of biotechnology. This interaction has given him a better idea of what a bioengineering career will be like.
Is your organization open to all majors or is it major specific?
BMES is open to all STEM majors. When it comes to finding new members for your organization, what type of students are you looking for?
We look for students who are interested in the biotech field or want to learn how bioengineers impact the world.
When are your meetings and is there a membership fee?
Our meetings are held every other Friday from 12-1 p.m. in the Mechanical Engineering Conference Room. The membership fee is $15.
How can students find more information about your organization?
Students can learn more about the BMES by visiting our Facebook page, emailing us at sdsubmes@gmail.com or stopping by the SDSU bioengineering lab which is located in the Engineering Building, room E329.
What kind of activities does your organization plan/attend?
BMES plans a bioengineering symposium, an event where the bioengineering labs on campus present their research, as well as a bioengineering panel. We also regularly host guest speakers. BMES also plans tours of local biotech companies.
Which SDSU faculty have had an impact on your organization?
Professor Karen May-Newman, our faculty adviser, has helped BMES get to where it is today. She founded the club a few semesters ago and has had a big presence since. We are very grateful for her support.
More here:
Student Organization Spotlight: Biomedical Engineering Society - SDSU Newscenter
Bike riders can use the Zagster bikes for free during the first two hours
By Sandra Baltazar Martinez on February 7, 2017
Bryan Marty Martinez, a fourth year student and current GCAP director, led a team of students to implement UCRs first Zagster bike share program. sandra baltazar martnez
Riding on two wheels to get from one end of campus to the other just got easier.
A few weeks ago, 50 new bicycles became available to all UC Riverside students, staff, and faculty members, via UCRs Zagster Bike Share program, UCRs first campuswide bike share program. The white bikes are parked at seven locations throughout the campus, including lot 30, Glen Mor, and near the HUB. They can be accessed by downloading an app on both iPhone andAndroid.
This program came together with the collaboration of Green Campus Action Plan (GCAP), Associated Students of UCR (ASUCR), Transportation and Parking Services (TAPS), and the Student Recreation Center (SRC). Procurement Services and Capital Planning also played key roles.
The real work started more than a year ago, with the vision of a former UCR undergraduate student Michael Ervin, who served asASUCR vice president of Campus Internal Affairs. Then, this past summer, fourth-year student and current GCAP Director Bryan Marty Martinez worked all summer to finalize logistics, contracts, and execution of the program.
When students returned from winter break, 50 Zagster bikes and 100 racks were in place. Theyve quickly becoming popular, probably because riders use the bike for free for the first two hours. After that, its $1 per hour, and charges cap at $6 per day. A local vendor has been contracted to service bikes, Martinez said.
Martinez, a sustainability studies major and political science minor, said GCAP is the primary funder of the bike share program because it wants to support UCRs bike-friendly atmosphere, as well as offer an inexpensive mode of transportation to the campus community.
Students can get to class on time, its environmentally friendly, and for commuters, it can help expedite their arrival to campus, Martinez said.
He also encourages staff and faculty members to pick up a bike. Why not? Everyone is doing it. You can improve your health, and getting used to riding a bike [again will be] like a childhood memory, Martinezsaid.
William Grover, assistant professor of bioengineering at the Bourns College of Engineering, decided to ride a bike on a recent January morning. sandra baltazar martnez
Assistant Professor of bioengineering at the Bourns College of Engineering, William Grover, is excited about having access to a bike on campus. This way he can bike to a meeting on the other side of campus, or ride to pick up lunch at University Village.
Groveris hopeful the bikes will help students arrive at his class on time, especially when walking from University Village.
On a recent afternoon, Grover checked out a bike and roamed the campus.
It made me realize how bike-friendly our campus is broad paths and car-free, really well suited for a bike share. I was surprised by how nice the bikes are lots of gears, easy-to-adjust seat, a little basket for storing stuff, even a bracket for holding the bike lock, Grover said.
William Grover, assistant professor of bioengineering, shows $0 charges after riding the bike.
For Jacquelyn I. Gonzlez, a graduate teaching assistant pursuing her masters in Public Policy, the bike share program and its free two-hour policy was great news.
When I came across the Zagster station by the HUB and saw that it was free for two hours, I knew I had found the solution to my commuter problem. And with my late night classes and study sessions, it has also given me a better sense of safety in getting to my car in lot 26, Gonzlez said.
Zagster is a Massachusetts-based company that offers bike share programs to cities, businesses, and universities. The contract with Zagster runsthrough January 2018. After that, the program will be evaluated based on usage and interest from students, staff, and faculty members, said Laurie Sinclair, ASUCR executive director.
The bike share program is meant to provide convenience for the campus community, Sinclair said. Its also meant to encourage and inspire sustainability.
Here is how it works:
To sign up and find the nearest Zagster location: ASUCR Website.
Archived under: Inside UCR, ASUCR, bike share program, Bryan Marty Martinez, GCAP, Jacquelyn I. Gonzlez, Laurie Sinclair, SRC, TAPS, William Grover, Zagster
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Bike Share Program: Getting Around Campus on Two Wheels - UCR Today (press release)
February 24, 2017 Artistic rendering of RNA-DNA interactions. A 3-D structure of tightly coiled DNA is depicted as the body of a dragon in Chinese myth. Interacting RNAs are depicted as hairs, whiskers and claws, which are essential for the dragon to function. Credit: Victor O. Leshyk
Bioengineers at the University of California San Diego have developed a new tool to identify interactions between RNA and DNA molecules. The tool, called MARGI (Mapping RNA Genome Interactions), is the first technology that's capable of providing a full account of all the RNA molecules that interact with a segment of DNA, as well as the locations of all these interactionsin just a single experiment.
RNA molecules can attach to particular DNA sequences to help control how much protein these particular genes produce within a given time, and within a given cell. And by knowing what genes produce these regulatory RNAs, researchers can start to identify new functions and instructions encoded in the genome.
"Most of the human genome sequence is now known, but we still don't know what most of these sequences mean," said Sheng Zhong, bioengineering professor at the UC San Diego Jacobs School of Engineering and the study's lead author. "To better understand the functions of the genome, it would be useful to have the entire catalog of all the RNA molecules that interact with DNA, and what sequences they interact with. We've developed a tool that can give us that information."
Zhong and his team published their findings in the Feb. issue of Current Biology.
Existing methods to study RNA-DNA interactions are only capable of analyzing one RNA molecule at a time, making it impossible to analyze an entire set of RNA-DNA interactions involving hundreds of RNA molecules.
"It could take years to analyze all these interactions," said Tri Nguyen, a bioengineering Ph.D. student at UC San Diego and a co-first author of the study.
Using MARGI, an entire set of RNA-DNA interactions could be analyzed in a single experiment that takes one to two weeks.
The MARGI technique starts out with a mixture containing DNA that's been cut into short pieces and RNA. In this mixture, a subset of RNA molecules are interacting with particular DNA pieces. A specially designed linker is then added to connect the interacting RNA-DNA pairs. Linked RNA-DNA pairs are selectively fished out, then converted into chimeric sequences that can all be read at once using high-throughput sequencing.
Zhong and his team tested the method's accuracy by seeing if it produced false positive results. First, the researchers mixed RNA and DNA from both fruit fly and human cells, creating both "true" RNA-DNA pairs, meaning they're either fully human or fully fruit fly, and "false" RNA-DNA pairs, meaning they're half human and half fruit flythese are the ones that shouldn't be detected. The team then screened the entire mixture using MARGI. The method detected a large set of true RNA-DNA interactions, but it also detected approximately 2 percent of the false ones.
"This method is not perfect, but it's an important step toward creating a full functional annotation of the genome," said co-first author Bharat Sridhar, a visiting bioengineering researcher in Zhong's group.
Explore further: Size matters... and structure too: New tool predicts the interaction of proteins with long non-coding RNAs
More information: Bharat Sridhar et al, Systematic Mapping of RNA-Chromatin Interactions InVivo, Current Biology (2017). DOI: 10.1016/j.cub.2017.01.011
Far from just reading the information contained in the human genome, and in order to fully understand how it works, researchers aim to know the ins and outs of all the elements in this tiny regulated gear. Many laboratories, ...
Every cell has its own individual molecular fingerprint, which is informative for its functions and regulatory states. LMU researchers have now carried out a comprehensive comparison of methodologies that quantify RNAs of ...
After the 2003 completion of the Human Genome Project which sequenced all 3 billion "letters," or base pairs, in the human genome many thought that our DNA would become an open book. But a perplexing problem quickly ...
What used to be dismissed by many as "junk DNA" is back with a vengeance as growing data points to the importance of non-coding RNAs (ncRNAs)genome's messages that do not code for proteinsin development and disease. ...
An algorithm which models how proteins inside cells interact with each other will enhance the study of biology, and sheds light on how proteins work together to complete tasks such as turning food into energy.
Since the completion of the human genome an important goal has been to elucidate the function of the now known proteins: a new molecular method enables the investigation of the function for thousands of proteins in parallel. ...
Photographers, poachers and eco-tour operators are in the crosshairs of a Canadian conservationist who warns that tracking tags are being hacked and misused to harass and hunt endangered animals.
Bioengineers at the University of California San Diego have developed a new tool to identify interactions between RNA and DNA molecules. The tool, called MARGI (Mapping RNA Genome Interactions), is the first technology that's ...
Small "bubbles" frequently form on membranes of cells and are taken up into their interior. The process involves EHD proteins - a focus of research by Prof. Oliver Daumke of the MDC. He and his team have now shed light on ...
The first skirmish was fought last week in what could be a long war over a revolutionary patent on gene-editing technology, with colossal amounts of money at stake.
Scientists from The University of Western Australia have identified a tiny mutation in plants that can influence how well a plant recovers from stressful conditions, and ultimately impact a plant's survival.
The last Neanderthal died 40,000 years ago, but much of their genome lives on, in bits and pieces, through modern humans. The impact of Neanderthals' genetic contribution has been uncertain: Do these snippets affect our genome's ...
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New tool to map RNA-DNA interactions could help researchers ... - Phys.Org
About Bioengineering Bioengineering applies engineering principles and practices to living things, to solve some of the most challenging problems that face our world today.
The field of bioengineering seeks to integrate quantitative and design approaches to biological systems, encompassing a range of specific disciplines from macro to nano-scales.Bioengineering, also known as Biomedical Engineering, has traditionally been a field largely driven by biomedical applicationssuch as medical imaging, prosthetics, biomechanics and related fields. As knowledgein the biological and biophysical basis of cell function has increased, opportunities have expanded for advancing the understanding of cell and molecular scale functioning of organic matter, as well as designing applications in diverse areas of medical treatment and diagnostics, tissue regeneration and replacement, biologically-inspired devices, energy, and the environment.
Bioengineering at Berkeley We seek to define the new discipline of bioengineering by concentrating on cutting-edge research and training of advanced undergraduate and graduate students to be the next leaders in the field.
At Berkeley, our research and teaching agenda has evolved into five primary areas, with many overlaps, which we consider to be foundational: regenerative medicine and therapeutic engineering, biomaterials and nanotechnology, instrumentation, computational biology and bioinformatics, systems and synthetic biology. Our principal focus ison a broad strategy of translational bioengineering, describing our interest and emphasis on translation of developments from our laboratories into the clinic, into new companies, and into industry.
The Department of Bioengineering at UC Berkeley grants the Bachelor of Science and Master of Engineering degrees in bioengineering, and jointly grants the Ph.D. and Masters of Translational Medicine degrees in bioengineering with the University of California, San Francisco.
Our History Established in 1998, the Department of Bioengineering at UC Berkeley draws on the talents of a diversegroup of outstanding faculty, and upon the long history of interdisciplinary bioengineering research at UC Berkeley. Prior to 1998, undergraduate education flourished as an emphasis in the Engineering Science Program. BioE graduate education was formalized here in 1983 with the founding of the UC Berkeley UCSF Graduate Group in Bioengineering, which continues to administer our graduate program.
The Department of Bioengineering was the firstnew department to be established within the College of Engineering in over 40 years, and has seen astounding growth in size and demand since its founding.
Growth and ExcellenceThe BioE graduate and undergraduate programs are continually ranked in the Top 10 according to US News & World Report. A more detailed study of graduate education by the National Research Council (NRC rankings) has placed our graduate program among the very top in the country.
The bioengineering department is part of theCollege of Engineering, a world-renowned program consistently ranked in the top three overall engineering schools in the country by U.S. News & World Report. UC Berkeley as whole has been ranked as the top public university in the world.
Thank you for your interest in bioengineering at Berkeley. Please continueto explore our website for more information, orcontact us.
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About us - UC Berkeley Department of Bioengineering
Biological engineering or bio-engineering (including biological systems engineering) is the application of concepts and methods of biology (and secondarily of physics, chemistry, mathematics, and computer science) to solve real-world problems related to life sciences or the application thereof, using engineering's own analytical and synthetic methodologies and also its traditional sensitivity to the cost and practicality of the solution(s) arrived at. In this context, while traditional engineering applies physical and mathematical sciences to analyze, design and manufacture inanimate tools, structures and processes, biological engineering uses primarily the rapidly developing body of knowledge known as molecular biology to study and advance applications of organisms and to create biotechnology.This may eventually include the possibility of biologically engineering machines and 3D printing that re-order matter at a molecular scale. Physicist Richard Feynman theorized about the idea of a medical use for these biological machines, introduced into the body, to repair or detect damages and infections. . Feynman and Albert Hibbs suggested that it might one day be possible to (as Feynman put it) "swallow the doctor". The idea was discussed in Feynman's 1959 essay There's Plenty of Room at the Bottom.[1]
Industrial bio-engineering extends from the creation of artificial organs by technical means or finds ways of growing organs and tissues through the methods of regenerative medicine to compensate reduced or lost physiological functions (Biomedical Engineering) and to develop genetically modified organisms, i.e., agricultural plants and animals as well as the molecular designs of compounds with desired properties (protein engineering, engineering enzymology). In the non-medical aspects of bio-engineering, it is closely related to biotechnology, nanotechnology and 3D printing.
An especially important application is the analysis and cost-effective solution of problems related to human health (human bioingeneering), but the field is much more general than that. For example, biomimetics is a branch of biological engineering which strives to find ways in which the structures and functions of living organisms can be used as models for the design and engineering of materials and machines. Systems biology, on the other hand, seeks to exploit the engineer's familiarity with complex artificial systems, and perhaps the concepts used in "reverse engineering", to facilitate the difficult process of recognition of the structure, function, and precise method of operation of complex biological systems.
The differentiation between biological engineering and biomedical engineering can be unclear, as many universities loosely use the terms "bioengineering" and "biomedical engineering" interchangeably.[2] Biomedical engineers are specifically focused on applying biological and other sciences toward medical innovations, whereas biological engineers are focused principally on applying engineering principles to biology - but not necessarily for medical uses. Hence neither "biological" engineering nor "biomedical" engineering is wholly contained within the other, as there can be "non-biological" products for medical needs as well as "biological" products for non-medical needs (the latter including notably biosystems engineering).
Biological engineering is a science-based discipline founded upon the biological sciences in the same way that chemical engineering, electrical engineering, and mechanical engineering[3] can be based upon chemistry, electricity and magnetism, and classical mechanics, respectively.[4]
Biological engineering can be differentiated from its roots of pure biology or other engineering fields. Biological studies often follow a reductionist approach in viewing a system on its smallest possible scale which naturally leads toward the development of tools like functional genomics. Engineering approaches, using classical design perspectives, are constructionist, building new devices, approaches, and technologies from component parts or concepts. Biological engineering uses both approaches in concert, relying on reductionist approaches to identify, understand, and organize the fundamental units, which are then integrated to generate something new.[5] In addition, because it is an engineering discipline, biological engineering is fundamentally concerned with not just the basic science, but its practical application of the scientific knowledge to solve real-world problems in a cost-effective way.
Although engineered biological systems have been used to manipulate information, construct materials, process chemicals, produce energy, provide food, and help maintain or enhance human health and our environment, our ability to quickly and reliably engineer biological systems that behave as expected is at present less well developed than our mastery over mechanical and electrical systems.[6]
ABET,[7] the U.S.-based accreditation board for engineering B.S. programs, makes a distinction between biomedical engineering and biological engineering, though there is much overlap (see above). Foundational courses are often the same and include thermodynamics, fluid and mechanical dynamics, kinetics, electronics, and materials properties.[8][9] According to Professor Doug Lauffenburger of MIT,[10][11] biological engineering (like biotechnology) has a broader base which applies engineering principles to an enormous range of size and complexities of systems ranging from the molecular level - molecular biology, biochemistry, microbiology, pharmacology, protein chemistry, cytology, immunology, neurobiology and neuroscience (often but not always using biological substances) - to cellular and tissue-based methods (including devices and sensors), whole macroscopic organisms (plants, animals), and up increasing length scales to whole ecosystems.
The word bioengineering was coined by British scientist and broadcaster Heinz Wolff in 1954.[12] The term bioengineering is also used to describe the use of vegetation in civil engineering construction. The term bioengineering may also be applied to environmental modifications such as surface soil protection, slope stabilization, watercourse and shoreline protection, windbreaks, vegetation barriers including noise barriers and visual screens, and the ecological enhancement of an area. The first biological engineering program was created at Mississippi State University in 1967, making it the first biological engineering curriculum in the United States.[13] More recent programs have been launched at MIT [10] and Utah State University.[14]
Biological engineers or bio-engineers are engineers who use the principles of biology and the tools of engineering to create usable, tangible, economically viable products.[15] Biological engineering employs knowledge and expertise from a number of pure and applied sciences,[16] such as mass and heat transfer, kinetics, biocatalysts, biomechanics, bioinformatics, separation and purification processes, bioreactor design, surface science, fluid mechanics, thermodynamics, and polymer science. It is used in the design of medical devices, diagnostic equipment, biocompatible materials, renewable bioenergy, ecological engineering, agricultural engineering, and other areas that improve the living standards of societies.
In general, biological engineers attempt to either mimic biological systems to create products or modify and control biological systems so that they can replace, augment, sustain, or predict chemical and mechanical processes.[17] Bioengineers can apply their expertise to other applications of engineering and biotechnology, including genetic modification of plants and microorganisms, bioprocess engineering, and biocatalysis.
Because other engineering disciplines also address living organisms (e.g., prosthetics in bio-mechanical engineering), the term biological engineering can be applied more broadly to include agricultural engineering and biotechnology, which notably can address non-healthcare objectives as well (unlike biomedical engineering). In fact, many old agricultural engineering departments in universities over the world have rebranded themselves as agricultural and biological engineering or agricultural and biosystems engineering. Biological engineering is also called bioengineering by some colleges, and biomedical engineering is called bioengineering by others, and is a rapidly developing field with fluid categorization. Depending on the institution and particular definitional boundaries employed, some major fields of bioengineering may be categorized as (note these may overlap):
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Biological engineering - Wikipedia