Mr.

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Can someone help me in this, of course I am new on this line.

I have a client whose factory is fitted with 9 units of smoke spill fan, incidently this section caught fire at the AHU room in which the SSF panel was fitted. My problem now is that, they do not have the soft and hard copy of the sc

Dancing Creek Farm

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What is the formula to calculate the verticle force in horse power or watts of a boat or other vessle on a dead weight as the vessel is lifted by a wave or swell? I have a displacement of 3,600 pounds with a rise of 8' in 5 seconds. Do I first need to calculate the density from volume/displacement?

Electo-mechanical loads

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Dear Team,

We always have conflictinig issues between electrical and mechanical departments on loading of load. The electircal says no-load current is OK and hence motor is perfect, mechanical load is the problem. The mECHANICAL Claims all the loads / alignment are perfect and motor is the prob

Black Ninja Monday is When the Commenter Trolls Get Their Due [Comments]

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Several star commenters have noted recently that the troll factor is rising again. This post is reminder that all comments wasting words and the comment moderator's time wondering about such issues as "why does gizmodo love/hate/get paid by company XYZ?" may result in zero warnings and then a ban. And whatever happens to your comment account, remember: it's not my fault if you lose your account because you said something stupid. Black Ninja Monday is when the action goes down, so you've got two days to turn things around. The obvious choices: You can have fun in troll hell, or join the ranks of the thoughtful, starred, proud and clever commenters everyone appreciates. Again, Monday: that's when there'll be internet blood everywhere. But it won't be mine. More »


The problem with Comparative Whole Genomics……

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I have been having this debate with a good friend and mentor.


I think Complete Genome Comparison could be a Killer App.

He thinks it could be a legal and scientific nightmare.

I think he's right.

Let's really think about this for a second. If history has anything to say about human behavior we need look no further than the secrecy with which gene sequences were hunted.

Hell, even Science makes mention of it several times. The Article "Data Hoarding Blocks Progress in Genetics" might be a good read if you are interested.

Guys like Daniel MacArthur over at Genetic future point out some good points about the difficulty in making sense of all the noise that exists in genomes. But the problems go even further than that. Hell, CNV can differ in IDENTICAL TWINS!!!! Say Wha?

So what do we have to say about this? Phenotype and comparison are kings. Databases of "normals" and disease afflicted need to be developed. They need to be curated, they need to be "shared"

Ahem, excuse me? Did you say "shared?"

Yes, I did say shared.

Exec/USGOVT/BGI/UK/Etc- "Well, sure we would like to give that idea more credence and study it. And the implications it may bring. Would you be so kind as to forward your attorney's information so that our attorneys can consult with yours in order to bankrupt you and send you away with you radical thinking?"

He has me convinced (a tough thing to do) that the level of collaboration amongst human geneticists and Venture Capitalists might not be exactly the level of their physician brethren....

What happens when you get access to a database, but not "all of it"

Who pays? Who benefits? Who gets rights of discovery? Who pays the Nosferatu? (sorry Dan)

With Sequencing as a Service, do you have these problems licked? Probably not.

So when Daniel points out every geneticist afflicted with a disease feel good discovery, there are about 100 nightmare scenarios of chasing down rare variants that turn out to be nothing except a good excuse to burn through 10 million dollars........

I begin to say, well how can we pick that up quicker? Comparative Whole Genomics.

Great, which database do I start with? Do I have to use 20 or 200 databases? How can I afford such work? Which one of the 200 won't make a play legally to own my discovery?

Ahh, yes. It is a good time to be a genome centric attorney. But a nightmare to launch a business where you depend on someone else's database.........

The Sherpa Says: Yes, sugar plums, ponies and lemon drops for as far as the eye can see for Genomics! I hope Andy will bring this back to earth........Or maybe Glenn Close can show us where the fruit punch swimming pool is?

Re polarizing ceramic magnets.

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This may be an easy one for the right person but for me up to this point I have yet to ever do it on purpose.

Can the ceramic magnets in servo motors be re polarized, have their polar orientations moved, simply by brute force from a stronger electromagnetic field?

Reason being I have a lar

The FDA, 2c19 and the ACC

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Did anyone see the FDA issuance of the better warning that as many as 14% of patients will not benefit from Plavix/Clopidogrel?

Did anyone see the cold shower being poured on by the press and the cardiologists?

Christopher Cannon Assoc. Prof at Harvard says:
The ACC will need to develop protocols, "Thus a real conundrum"

He then says "I expect mass confusion in response to this FDA warning"

Well Chris, It's not as if we haven't been shouting from the rooftops about this for over a year now.......

"The test costs about 500 USD according to Courtney Harper PhD, Director of the FDAs division of chemistry and toxicology devices. But cost isn't the only issue."

Which BTW is false 23andME is cheaper......But wait, isn't that medicine?

"The time to get a result varies. It may be a few hours to a day or two, or other labs may take a few weeks"

This is absolutely true. It takes me 3 weeks for a test from Quest. I am certain that there has to be some lab to do it quicker.......

BUT, the FDA has only approved AmpliChip for this testing.....

This sounds to me like the FDA needs to approve some kits and PDQ with the ACC meeting coming up like,

My guess

1. The ACC will address and release its prelim algorithm

2. The ACC conference will have even further data regarding this released.

3. The last step is to FDA in some kits to do this test, quicker and more standardized.

We need a company that can direct us to

So the question, why all the cold water on this killer app? Well, because it is getting lumped in with DTC genomics, which is feeling a backlash from hype and failed promises. Or trying to play medicine.
As well as a flat disregard for medicine. So when the press and the healthcare providers are against you, you can feel it.

But this is what I have been frustrated about all along. I saw this coming. Doctors blowing off PGx thinking it is SNPChip Hype. Journalists pouncing on overpromising and intellectually dishonest DTC Genomics companies.....

This is why I was so mad about the blimp.

When something really awesome comes around, people are burned out from Open Bars......

The Sherpa Says: Let's really do this. Genomics and PGx IS medicine. Let's say it proud, Let's ay it loud. Quit screwing around to avoid regs. Let's how the world how we can use this to help mankind!