GameChanger DNA Bonus Builds When You Share This Video! (Yeti/110 bonus bucks no longer available) – Video

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Product Launch formula 3.2 Bonus here: http://www.youtube.com you can find the bonus LIST where you can see each bonus that you can get as more people join. My first bonus will be an iPad 2. You can get an iPad 2 and then when another person joins, that person will also get an iPad 2, and you will both get bonus #2

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GameChanger DNA Bonus Builds When You Share This Video! (Yeti/110 bonus bucks no longer available) - Video

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ROUTINE OF EXERCISES TO LOSE WEIGHT WITH THE BIOLOGICAL AND DOMESTIC GYMNASTICS OF LUIS MORI – Video

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FRIENDS OF YOUTUBE. I WANT THE LADIES ARE AT HOME UNDERSTAND HOW THE FAT IS REMOVED OF THE FATTY LAYER IF WAS CERTAIN THAT FOODS MAKE GET FAT THEN THE THIN ONES HAVE TO TAKE CARE TO DO NOT PUT ON WEIGHT; BUT THOSE WHO HAVE ALREADY GAINED WEIGHT WANT THE SOLUTION¿WHAT DO THEY HAVE TO DO TO RETIRE ALL THAT EXCESS OF FAT THAT THEY HAVE IN THEIR BODY? WHAT INFLUENCES DIRECTLY IN THE REDUCTION OF WEIGHT IS THE EXECUTION OF THE 21 EXERCISES THAT FORM THE ROUTINE AND EACH EXERCISE HAS A SPECIFIC BENEFIT WITHIN THE ROUTINE.

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ROUTINE OF EXERCISES TO LOSE WEIGHT WITH THE BIOLOGICAL AND DOMESTIC GYMNASTICS OF LUIS MORI - Video

BIOLOGICAL GYMNASTICS OF WEIGHT'S REDUCTION BY LUIS MORI-YEAR 2012 – Video

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FRIENDS OF YOUTUBE. IF WAS CERTAIN THAT FOODS MAKE GET FAT THEN THE THIN ONES HAVE TO TAKE CARE TO DO NOT PUT ON WEIGHT; BUT THOSE WHO HAVE ALREADY GAINED WEIGHT WANT THE SOLUTION¿WHAT DO THEY HAVE TO DO TO RETIRE ALL THAT EXCESS OF FAT THAT THEY HAVE IN THEIR BODY? WHAT INFLUENCES DIRECTLY IN THE REDUCTION OF WEIGHT IS THE EXECUTION OF THE 21 EXERCISES THAT FORM THE ROUTINE AND EACH EXERCISE HAS A SPECIFIC BENEFIT WITHIN THE ROUTINE.

See more here:
BIOLOGICAL GYMNASTICS OF WEIGHT'S REDUCTION BY LUIS MORI-YEAR 2012 - Video

Here are 101 ways to get good night sleep

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When it comes to good night sleep tips, everyone has his/her own tips to share with others. There are different types of sleep tips for different kind of sleep disorders. What ever we do, our aim is to get a good peaceful sleep. There are different forums for different sleep disorders and every sleep forum's motto is to help forum members or visitors to get rid of their sleep problems and get a good night sleep.

There are many sleep tips for Insomnia, Sleep Apnea, Snoring, Restless Leg Syndrome, Narcolepsy, Baby Sleep, Circadian Rhythms, Hypersomnia and the list goes on Every one who visits our forum want to know how to get good night sleep, we share our personal experience with them, how we are working on to get rid of the sleep disorders. Those suffered/suffering from a sleep problem knows more than any one about that disorder. Read more...

AyurGold for Healthy Blood

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Thoughts from Digital Pathology Consultants on FDA Panel

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Amanda Lowe from Digital Pathology Consultants has a couple of recent nice posts on FDA panel at Pathology Visions last week. Check them out on her blog. She has been following this item and has some great insights and feelings on the matter.

Part 1: An Update on the FDA’s Regulation of Digital Pathology

Part 2: Digital Pathology is Not an LDT! Now What?

 

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Indica Labs Extends Capabilities for Neuroscience with Microglial Activation Analysis Software

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Product-microglia
Albuquerque, New Mexico   11/10/2011 – Indica Labs, Inc. extends its capabilities in the field of neuroscience by releasing a highly advanced image analysis software package for measuring microglial cell activation in brightfield microscopic images.  The software is the first of its kind for providing quantitative, objective, detailed metrics for measuring overall glial cell activation in brain tissue sections.

Microglial cells act as defenders of the brain and their activation level can be an important indicator of brain injury, disease, or toxins.  The measurement of microglial cell activation has become a critical aspect of research for many neurological diseases including Alzheimer’s disease, Parkinson’s disease, and autism.  Traditionally, these measurements are made by researchers who take on the arduous task of manually characterizing tens of thousands of cells on a single tissue sample.

Indica’s new patent pending software uses advanced image processing algorithms to automatically detect and measure microglial cells and their level of activation.  In addition to characterizing microglial cell activation, the software reports a wealth of additional measurements describing glial cell density, cell process length, thickness, and branching.  This depth of information is simply unattainable via manual microscopy methods.

Indica Labs, CEO Steven Hashagen remarked:

“We are pleased to be able to announce the release of this groundbreaking software.  It took an enormous amount of research and development effort to deliver this highly advanced software for microglial cell analysis.  Now these efforts can be leveraged by the talented scientists who are working on the important task of understanding and treating neurological diseases.”

Coupled with the axon quantification software released earlier this year, Indica Labs has moved into the forefront of technology providers for neuroscience research.  For more information about these products or any other Indica Labs products, please visit their website at http://indicalab.com/products.html, or contact info@indicalab.com to schedule a complementary demonstration.

###

About Indica Labs, Inc. 

Indica Labs provides sophisticated pathology image processing software for whole-slide tissue analysis.  Indica Labs software tools integrate seamlessly into leading digital pathology platforms to provide reproducible and highly quantitative data to pathologists in hospitals, academic medical centers, government research institutions, global pharmaceutical companies, and small biotech firms.  For more information, please visit http://www.indicalab.com.  Indica Labs products are intended for research use only.

 

Contact

Indica Labs, Inc. info@indicalab.com

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Invitation from 3DHISTECH: CaseCenter Webinar, November 15th – Register Now

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 3DHISTECH invites you to the CaseCenter Webinar, where you get a comprehensive insight into Digital Pathology visualization and demonstration presented by Mr. Ferenc Szip?cs, the Product Manager of CaseCenter project at the 3DHISTECH Ltd! 


Date: 15th of November, 2011.

Please choose between the following two sessions:

9:00 CET (13:30 IST, 16:00 SGT, 17:00 JST) session!

17:00 CET (11:00 EST, 10:00 CST, 8:00 PST) session!

If you choose the second session please follow the instructions described in this mail! 

Program of the CaseCenter Webinar:

- Introduction to CaseCenter
- Teleconsultation/Education
- User rights management
- Scan To CaseCenter directly
- Instant access to slides/ cases from anywhere in the world.

Please download and install the free version of Pannoramic Viewer software to see our digital slides during the teleconsultation part of the presentation! 


Please, join the CaseCenter Webinar of 3DHISTECH presented by the leading company in Digital Pathology!

This event requires registration.

Topic: Webinar CaseCenter
Host: Mr. Ferenc Szip?cs
9:00 CET (13:30 IST, 16:00 SGT, 17:00 JST) 15th of November, 2011.
Registration password: 2241

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To register for the online event
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1. Click here to register
2. Click "Register".
3. On the registration form, enter your information and then click "Submit".

Once the host approves your registration, you will receive a confirmation email message with instructions on how to join the event.

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For assistance
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You can contact Mr. Ferenc Szip?cs at:
ferenc.szipocs@3dhistech.com

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Articles published in past one month for Journal of Pathology Informatics ( J Pathol Inform)

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Abstracts: Pathology Informatics 2011 Meeting
 J Pathol Inform 2011, 2:43 (4 October 2011)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
Autofocus methods of whole slide imaging systems and the introduction of a second-generation independent dual sensor scanning method
Michael C Montalto, Richard R McKay, Robert J Filkins
J Pathol Inform 2011, 2:44 (19 October 2011)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
High-definition hematoxylin and eosin staining in a transition to digital pathology
Jamie D Martina, Christopher Simmons, Drazen M Jukic
J Pathol Inform 2011, 2:45 (19 October 2011)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
Evaluation and optimization for liquid-based preparation cytology in whole slide imaging
Roy E Lee, David S McClintock, Nora M Laver, Yukako Yagi
J Pathol Inform 2011, 2:46 (19 October 2011)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
Image microarrays (IMA): Digital pathology's missing tool
Jason Hipp, Jerome Cheng, Liron Pantanowitz, Stephen Hewitt, Yukako Yagi, James Monaco, Anant Madabhushi, Jaime Rodriguez-canales, Jeffrey Hanson, Sinchita Roy-Chowdhuri, Armando C Filie, Michael D Feldman, John E Tomaszewski, Natalie C Shih, Victor Brodsky, Giuseppe Giaccone, Michael R Emmert-Buck, Ulysses J Balis
J Pathol Inform 2011, 2:47 (29 October 2011)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
Standardization of whole slide image morphologic assessment with definition of a new application: Digital slide dynamic morphometry
Giacomo Puppa, Mauro Risio, Kieran Sheahan, Michael Vieth, Inti Zlobec, Alessandro Lugli, Sara Pecori, Lai Mun Wang, Cord Langner, Hiroyuki Mitomi, Takatoshi Nakamura, Masahiko Watanabe, Hideki Ueno, Jacques Chasle, Carlo Senore, Stephen A Conley, Paulette Herlin, Gregory Y Lauwers
J Pathol Inform 2011, 2:48 (29 October 2011)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]
Review of methods in medical informatics: Fundamentals of healthcare programming in Perl, Python and Ruby by Jules J. Berman
Alexis B Carter
J Pathol Inform 2011, 2:49 (29 October 2011)
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

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Join a free Ventana webinar on HER2 testing with the FDA-approved Dual ISH assay on Nov. 15

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Ventana Presents:
HER2 Dual ISH - Concordance, Interpretation & Troubleshooting

HER2_Dual_ISH

Title: Ventana Presents: HER2 Dual ISH - Concordance, Interpretation & Troubleshooting
Date: Tuesday, November 15, 2011
Time: 1:30 PM - 2:30 PM EST
Speaker: Eric E. Walk, MD, FCAP

The content provided in this webinar is intended for U.S. healthcare professionals. Space is limited.

Reserve your Webinar seat now at: https://www3.gotomeeting.com/register/546297062

During this webinar we will discuss:
- HER2 Testing Methodologies
- HER2 Dual ISH Concordance with FISH
- Pre-analytical Considerations
- HER2 Dual ISH Interpretation
- Troubleshooting

After registering you will receive a confirmation email containing information about joining the Webinar.

System Requirements:

PC-based attendees Required: Windows® 7, Vista, XP or 2003 Server
Macintosh®-based attendees Required: Mac OS® X 10.5 or newer

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Soenksen Steps Down as CEO of Aperio; Will Focus on Customer Partnerships and Development

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Aperio Strengthens Executive Team, Intends to Develop Deeper Customer Partnerships and Speed Innovation

Aperio Founder to focus on Customers and New Solutions; recruits David Schlotterbeck as CEO to lead Commercialization

Vista, CA –November 8, 2011 – Aperio, the global leader in providing digital pathology solutions that improve patient care, has announced that Dirk G. Soenksen, Aperio founder, President of the Digital Pathology Association, and inventor of the first ultra-fast scanner for digital pathology, will focus on customer partnership and leading the development and marketplace adoption of digital pathology solutions.

In his new role as President and Futurist, Soenksen will focus on creating deeper partnerships with customers and accelerating the development of innovative solutions that will enable pathologists to expand the scope of their practice and gain access to new tools that will enhance their role in providing personalized medicine.

“Aperio’s accelerating growth has created the need for additional leadership.  We have more systems installed than all competitors combined.  In addition, we have an exciting and well defined product roadmap that will enable pathologists to be more effective in supporting the patient’s care team,” said Soenksen.  “I intend to focus my time on customer needs, partnerships and on the execution of product and solution development.” 

“I am excited to have recruited David Schlotterbeck, retired CEO of CareFusion, to serve as Chief Executive Officer of Aperio.  Splitting leadership responsibilities allows the company to execute and scale with increasing speed,” said Soenksen. “Dave has a proven 20-year track record of creating value in the healthcare space and I look forward to working with Dave as he leads our efforts to commercialize our products and solutions globally.” 

“I am delighted to serve as CEO of Aperio and to work with Dirk and the Aperio team to improve patient care through digital pathology,” said Schlotterbeck. “I am stepping back into a full-time role because of my excitement about the business opportunity for Aperio to deliver products and solutions that can positively impact the practice of pathology.  Adoption of digital pathology is accelerating globally and I’m thrilled to help Aperio achieve worldwide growth.”

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A letter to digital pathology companies from a group of pathologists for digital pathology

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Dear manufacturer,

We are a group of pathologists who appreciate your vision, inventions and innovations.  There is unlikely more than a handful of pathologists who on some level do not realize the advantages of digital pathology when compared with light microscopy.  The ability for multiple people to view the same slide at the same time, independent of slide or pathologist location and consult with colleagues or view remote slides to assist in patient care remains one of single greatest innovations in the day-to-day practice of pathology over the past several decades.  

PathvuIn our practice currently, we use video or scanner generated images to render diagnoses for remote frozens, immediate fine needle aspirations, image analysis, image morphometry, consults across our group or to other specialists and experts, virtual IHC, virtual consults, education, conferences, tumor boards and research.  It has been a useful adjunct technology just as IHC, improved laboratory information systems, voice recognition technologies and molecular techniques have. 

It is a rare day when an image other than that generated from a microscope itself is not used in some fashion to support the work of our pathology group caring for our patients.  

Multiheadmicroscope

We understand that last week the FDA and others presented at a panel at the annual Pathology Visions supported by the Digital Pathology Association (DPA) and others to review the requirements on regulating devices and software that comprise a digital pathology system.

We have been following this discussion since industry representatives and pathologist leaders in digital pathology met in October of 2009.  At that meeting we believe the FDA stated WSI systems are not class 1 exempt and therefore subject to pre-market approval (PMA).  Topics such as intended use which the FDA relies heavily upon, nature of the systems, patient safety and effectiveness were discussed in the available presentation entitled "Digital Pathology Devices Panel Meeting" presented by a FDA representative.

Prior to that meeting, specific clearances were given for image analysis and digital read applications for HER2 and PR were given a "green light" by the FDA.  More recently, another digital pathology system in addition to the slide stainer and immunohistochemical stain for HER2 were given the "go ahead" for digital reads.

In the past two years between public discussions, it is also our understanding that a DPA FDA Task Force representing a coalition of industry leaders has been in discussions with the FDA and projects such as "Project Pink" have been conducted to add to the body of knowledge towards clearance of whole slide imaging for primary H&E diagnosis.  

This is the good news.  The bad news now seems that despite not hearing much since October of 2009 we now know that these devices and systems will be regulated as Class 3 devices for primary H&E diagnosis although no mention of education, research, tumor board, previously cleared image analysis and interpretations nor consultations was discussed.  Additionally, a representative from CMS (which manages CLIA) stated that whole slide imaging could not be self-validated within a U.S. laboratory setting.

Our group has a difficult time reconciling prior clearances for immunohistochemical stains and no mention of consultations, which in many cases may represent the "primary" diagnosis that precedes a treatment and/or management plan or appropriate follow-up (this of course is the very reason someone is actually consulted in the first place much like any other specialty or industry that relies on sub-specialists to answer specific questions - in the case of pathology it is a diagnosis) and now a requirement for primary H&E diagnosis.   

Nonetheless, now we can stop worrying about what the FDA was going to say and prepare to cross this barrier with you.

While primary H&E diagnosis may not be our primary application we have no reservations about using it for such and offer our services to assist with your submissions.  Like thousands of laboratories in this country, we accession thousands of specimens annually and generate tens of thousands of slides from a broad range of specimen and part types encompassing a wide range of diagnoses, both neoplastic and non-neoplastic in nature.  We all recognize this is an important part of the diagnostic process but is best when used in conjunction with past medical history, clinical history, presentation, family history (when applicable) and gross clinical or surgical findings.  Fortunately, this information is commonly available or presented at the time of biopsy or surgery.  We are use to validating tests, technologies and procedures. CAP, CLIA and JCAHO accreditation mandate competency for laboratories for successful inspections and accreditations.  It happens on a daily basis.  Pathologists are also the consummate physicians when it comes to self-regulation and validation in terms of proficiency testing, internal quality assurance, mandatory internal peer reviews and external reviews in the best interests of diagnostic accuracy and patient safety.  As you know, much of this is commonly being done with digital pathology today.

Fortunately, more good news for both you as a provider of technology and we as consumers know that there is a long history of being able to make an H&E diagnosis off a computer monitor. In fact, many of us remember this newspaper headline from 1986 (Colburn D. The next best thing to being there.  And now, diagnosis by satellite. Washington Post 1986;August 27:7 - click on image to enlarge):

                               Satellitediagnosis

Since this proof-of-concept was successful, a search of PubMed for terms such as "digital pathology", "telepathology" and "whole slide images" reveals hundreds of peer-reviewed studies and publications with thousands of cases studied showing the effectiveness and validity of H&E diagnoses rendered with images on a computer monitor compared with conventional light microscopy.  A few historic notables include work done by the Veterans Administration Healthcare System (Dunn), University Health Network (Evans) and the U.S. Military Healthcare System (Kaplan) as examples of early validations and ongoing remote primary H&E diagnostic pathology services.

More recently, several peer-reviewed articles have been published suggesting that whole slide images offer not only equivalent accuracy when compared with "truth diagnoses" but actually may be superior to conventional microscope reads and offer not only better diagnoses but access of the right slide to the right person at the right time (i.e. primary diagnosis) in addition to the "same slide, same time" value proposition (i.e. secondary consultation) and more offer more intangibles not possible with glass slides alone.

A study in e-pub ahead of print in Clin Transplant (2011 Sep 29) looking at Banff score reproducibility from several folks at the University of Alberta who know a thing or two about this as they wrote the guidelines recently published "Superiority of virtual microscope versus light microscopy in transplantation pathology".  The authors conclude "The agreement for acute rejection between virtual and glass slides was not different from the agreement between two readings of glass slides. Thus, virtual microscopy is a reliable and more reproducible technology and has several advantages over glass slides, e.g., accessibility via internet, no fading. We recommend virtual microscopy for transplant diagnostics, including utilization for clinical trials."  

A group of researchers in France recently published "Prostate needle biopsy examination by means of virtual microscopy" and concluded "Virtual microscopy does not compromise, but might improve, the accuracy of grading in prostate needle biopsies".  

Thirdly, a collaboration of researchers in Denmark recently looked at "Automated digital volume measurement of melanoma metastases in sentinel nodes predicts disease recurrence and survival".

Last, but not least, multiple clinical investigators from several institutions and laboratories in Pittsburgh and Indianapolis recently published their experience with "Interinstitutional and interstate teleneuropathology". Lessons learned from this successful venture can be used to facilitate future efforts in this ever-growing practical vehicle for distributing pathology subspecialty expertise.

The time has come.  

To these pioneers we say, you are welcome to read our kidney transplants that are "rule out rejection" or compare thousands of our prostate biopsies and prostatectomies to insure accurate Gleason grading. Clearly we alone with our microscopes cannot automate volume of metastases in lymph nodes nor do many groups have immediate subspecialty expertise when the need arises.  

To all of the digital pathology technology providers we say that while we don't agree with the FDA requirement for PMA for your devices and software, we are ready to assist with the appropriate submissions and studies for what necessary clearance for us to provide the highest level of care possible to our patients with the help of your innovations to find solutions for everyday needs not unique to our group or laboratory.  Validated systems that can provide safe and reliable H&E reads will provide countless opportunities and together pathologists and technology providers can succeed.

Sincerely yours,

Pathologists for Digital Pathology 

 

 

 

 

 

 

 

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