Brainiac: The history and science of doping

The return of the Olympics means that we'll get to enjoy some of those weird and delightful summer sports -- stuff like archery, handball, and synchronized swimming. Unfortunately, it also means the return of a thorny and frustrating subject: doping. In Run, Swim, Throw, Cheat, Chris Cooper, a professor of biochemistry at the University of Essex, provides an extraordinarily thorough account of the history and science of drugs in sports. We tend to think about doping in a relatively unsophisticated way, Cooper argues: It's bad, and we want to stop it. In fact, however, the science of doping is extraordinarily complex, and its history is nuanced and surprising. We need to understand doping better.

The first thing to grasp about doping, Cooper writes, is that, for most of history, no one's cared about it -- the idea of "doping" simply didn't exist. The ancient Greeks were entirely open about their use of nutritional and pharmaceutical aides: "Charmis of Sparta swore that dried figs led him to Olympic gold in 668 B.C.," Cooper writes, while the great Greek physician Galen "noted the positive benefits of eating herbs, mushrooms, and testicles." In 1904, runner Thomas Hicks won the St. Louis Olympic Marathon "on a combination of strychnine injections laced with brandy," and no one seemed to mind; in the inter-war years, scientists on both sides of the Atlantic openly and enthusiastically endorsed performance-enhancing drugs, including cocaine. In the 1930s, British soccer teams proudly boasted about the supplements they used: the Wolverhampton Wanderers, for example, "informed the media of their latest pharmaceutical tricks, publicizing their use of extracts of monkey glands in the newspaper the News of the World." Doping was banned at the Olympics in 1938, but still didn't have a real stigma -- professional athletes continued to use drugs.

For most of history, Cooper writes, "The debate, as far as we can judge, was about methods not morals. The view seemed to be that any way to obtain an edge was fine." Really, Cooper argues, it should come as no surprise that no one cared about doping: Ordinary people were enthusiastic about drugs in everyday life, too. In the 1940s and 50s, it was totally normal for a person to pop an amphetamine pill to boost his mood. It was only when society as a whole turned against drugs after the 1960s that doping in sports became a truly moral issue.

So we are still working out own attitudes toward doping, which are relatively recent -- and those attitudes must contend with the science of doping, which, Cooper shows, is equally double-edged. In the first place, it's hard to know what really works -- and, therefore, which offenses an athlete ought to be punished for. Clinical trials of performance-enhancing drugs, he points out, are of limited relevance to elite athletes, since they have bodies which differ in substantial ways from those of even very fit ordinary people. And, at the highest levels, elite athletes often possess built-in advantages which are 'unfair,' and which can be arranged on a spectrum along with pharmaceutical or nutritional advantages. Some athletes, for example, are "doped" by their genes -- like the Finnish skier Eero Mantyranta, who won seven Olympic medals, in part because he possessed a mutant gene which caused his body to over-produce EPO, a hormone which drives the production of red blood cells. EPO, as it happens, is also a performance-enhancing drug. Similarly, a small percentage of female athletes, Cooper points out, are born with hormonal profiles which give them unusual strength and speed. Above and beyond these issues, there's the fact of "technological doping" -- the benefits which an economically advanced home country can provide for an athlete-in-training.

Doping, in short, is complicated, and hard to talk about in a monolithic way. The only way to make sense of it is to think very carefully, on a case-by-case basis, about which sorts of interventions constitute effective, meaningful cheating. (Some doping interventions might in fact boil down to the placebo effect.) Unfortunately, our approach to doping is as inconsistent as our policy on recreational drugs. Caffeine, for example, has a demonstrable and substantial affect on athletic performance, and yet no one's outlawed it -- almost certainly because it's legal in civilian life. This suggests that many of our attitudes about doping may have little to do with sports. Instead, they proceed out of our moral concerns about drug use in general.

Cooper devotes most of the book to a fine-grained discussion of the science of doping, and shows that it's full of surprising wrinkles and exceptions. As a whole, his account suggests that we are not spending enough money and time to really understand the problem. Ultimately, he makes the case for a more empirical and pro-active approach to thinking about drugs in sports, driven by research. More research would help us anticipate new developments and concentrate on those doping practices which truly create unfairness. "We can no more 'win' a war on drugs in sport than we can 'win' a war on drugs in society," he concludes -- the best we can do is be informed, and to focus on increasing fairness, one case at a time.

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Brainiac: The history and science of doping

Tracking breast cancer cells on the move

Public release date: 14-Jun-2012 [ | E-mail | Share ]

Contact: Angela Hopp 240-283-6614 American Society for Biochemistry and Molecular Biology

Breast cancer cells frequently move from their primary site and invade bone, decreasing a patient's chance of survival. This process of metastasis is complex, and factors both within the breast cancer cells and within the new bone environment play a role. In next week's Journal of Biological Chemistry "Paper of the Week," Roger Gomis and colleagues at the Institute for Research in Biomedicine in Spain investigated how breast cancer cells migrate to bone.

In particular, they examined the role of NOG, a gene important to proper bone development. Previously, NOG was associated with bone metastasis in prostate cancer, but its specific role in breast cancer to bone metastasis remained unknown.

Gomis and colleagues showed that once breast cancer cells are on the move NOG enables them to specifically invade the bone and establish a tumor. It does this in two ways. First, NOG escalates bone degeneration by increasing the number of mature osteoclasts (bone cells that break down bone), essentially creating a spot in the bone for the metastatic breast cancer cells to take up residence. Second, NOG keeps the metastatic breast cancer cells in a stem-cell-like state, which enables them to propagate and form a new tumor in the bone environment.

Gomis explains that the reason NOG expression leads to an increased potential for breast cancer to bone metastasis is because it not only affects features inherent to aggressive cancer cells (such as the ability to establish a new tumor) but also influences properties of the bone environment (such as osteoclast degeneration of bone).

###

From the article: "Identification of NOG as a specific breast cancer bone metastasis-supporting gene" by Maria Tarragona, Milica Pavlovic, Anna Arnal-Estap, Jelena Urosevic, Mnica Morales, Marc Guiu, Evarist Planet, Eva Gonzlez-Surez, Roger R. Gomis

Link to "Paper in Press": http://www.jbc.org/content/early/2012/04/30/jbc.M112.355834.full.pdf+html

Corresponding author: Roger R. Gomis, Oncology Programme, Institute for Research in Biomedicine in Barcelona, Spain; e-mail: roger.gomis@irbbarcelona.org

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UNC’s Saskia Neher selected as 2012 Pew Scholar

Newswise CHAPEL HILL, N.C. - Saskia B. Neher, PhD, assistant professor in the department of biochemistry and biophysics at the University of North Carolina School of Medicine, was one of twenty-two of Americas most promising scientists to be named Pew Scholars in the Biomedical Sciences by the Pew Charitable Trusts.

Neher is the eleventh such recipient for UNC since the program began in 1985 and she is one of 8 women among 22 awardees, overall, nationwide.

The 2012 Pew Scholars will join a select community that includes MacArthur Fellows, recipients of the Albert Lasker Medical Research Award and three Nobel Prize winners. The program encourages early-career scientists to advance research that leads to important medical breakthroughs and treatments.

Nehers research explores the molecular systems that help to activateand disablethe breakdown of fat. When we consume food rich in fat, molecules called lipases break down the fat so that it can be used as a source of fuel or be stored. In humans, defects in a lipase called LPL increase an individuals risk of cardiovascular disease. The activity of this molecule is regulated by a pair of proteins: one that activates LPL and another that switches it off when an animal fasts. Neher uncovered evidence that suggests how the activating protein functions.

Nehers work now will be to determine how the regulators of LPL interact, using sophisticated approaches in biochemistry, molecular biology and crystallography. Her research should provide insights into the regulation of an important process that could produce new targets for the treatment or prevention of cardiovascular disease.

Pew is pleased to provide this countrys most ambitious and dedicated scientists with timely funding that enables them to explore novel areas of investigation early in their careers, at what may be the most inventive and creative period in their research, said Rebecca W. Rimel, president and CEO of The Pew Charitable Trusts.

The program has invested more than $125 million to fund over 500 scholars. Recipients receive $240,000 over four years to pursue their research without restriction. Applicants are nominated by an invited institution and demonstrate both excellence and innovation in their research. This year, 179 institutions were requested to nominate a candidate and 134 eligible nominations were received.

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UNC's Saskia Neher selected as 2012 Pew Scholar

Novel biochemistry in Bovine immunodeficiency virus [erv]

Many roads lead to Rome there is no one right way to solve an evolutionary hurdle. Viruses encounter the same evolutionary problems, but have evolved lots and lots and lots of different solutions to the exact same problems. Random chance of mutations + the bumbling blindness of natural selection (good enough is selected, not BEST!) means all that bumbling mess leads to different solutions. Some might work better than others, but they all work, and thats good enough.

Its easy to comprehend an RNA virus doing something differently than a very distantly related DNA virus. But differences exist between closely related viruses as well. We all know no-new-genes-no-new-functions Michael Behe and his Creationist BFFs hate the evolutionary capacity of new-genes-new-functions HIV-1. They have to hate its cousin Bovine immunodeficiency virus too:

The bovine immunodeficiency virus Rev protein: identification of novel nuclear import pathway and nuclear export signal among retroviral Rev/Rev-like proteins

There are lots of different ways to get a protein. Retroviruses operate like a sheet cake it makes one bit mRNA that gets cuts up into lots of little mRNAs as it leaves the nucleus, which go one to be translated into all the proteins the retrovirus needs.

But then how to you get a retroviral genome into the babby viruses? The retroviral genome is a big uncut piece of mRNA. If it always gets cut up when it leaves the nucleus, how can you ever get that big uncut RNA genome into new viruses?

Lentiviruses have an answer to this dilemma Regulator of Virion Expression, Rev.

Rev escorts the mRNA out of the nucleus, so it can be chopped up in different ways to get different retroviral proteins, or, prevent the RNA from being cut entirely so full genomes can be packaged into babby viruses.

And of course, its not just about Rev getting out of the nucleus with its RNA companion. It must also be able to get itself into the nucleus. Proteins like Rev are made in the cytoplasm on ribosomes it needs to perform a few tricks to get itself into the nucleus to pick up its RNA buddy.

So Rev does two things gets into the nucleus, gets out of the nucleus with RNA. Gets into the nucleus, gets out of the nucleus with RNA. Over and over.

You would think that Rev from HIV and Rev from BIV would look and behave in the same manner. Theyre the same protein from the same family of retrovirus (lentivirus) that accomplish the same function.

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Novel biochemistry in Bovine immunodeficiency virus [erv]

Project L.E.A.N. Childhood Obesity Prevention Program Shows Excellent Results at the End of Its Second Year

Pepperidge Farm, Inc., Norwalk Hospital, Norwalk Health Department and Jefferson Elementary School Join Forces to Combat Childhood Obesity

NORWALK, Conn.--(BUSINESS WIRE)--Two hundred second and third graders at Jefferson School are ending the school year on a very healthy note. These students now have a significantly broader knowledge base about the importance of good nutrition and physical activity. Furthermore, they have made behavioral changes that will improve their long-term health. This is all due to the instruction they received from Project L.E.A.N. (Learning with Energy from Activity and Nutrition), a childhood obesity prevention program being offered at Jefferson School in Norwalk. The pilot program was started in 2010 through collaboration between Pepperidge Farm, Inc., Norwalk Hospital, Norwalk Department of Health, and Norwalks Jefferson Elementary School.

In particular, the principal at Jefferson School, John Reynolds, and the teachers deserve much of the credit for this programs success. From the very beginning, everyone including the students, teachers, parents and partners embraced the Project L.E.A.N. approach to improve the childrens health.

Project L.E.A.N. was designed to improve the overall health of children by teaching them lifelong habits of healthy eating and exercise. The program includes a breakfast boot camp, in-school nutrition classes taught by Cindy Sherlock MS, RD, CD-N, a dietician at Norwalk Hospitals Clinical Nutrition Department, and after school family events.

At the end of the second year, the program results are excellent. The students who have gone through the program have demonstrated a significant increase in their knowledge about good nutrition which has led to positive behavioral changes, says Ruthann Walsh, Director, Corporate Citizenship at Pepperidge Farm and one of the programs organizers. For example, the vast majority of the children now understand that it is unhealthy to be overweight and furthermore, they can cite specific chronic medical conditions that can arise from being overweight such as diabetes, heart disease and cancer. The children who have not gone through Project L.E.A.N. are not nearly as aware of these potential health risks. Additionally, Project L.E.A.N. students have dramatically reduced their consumption of sugar sweetened beverages, replacing them with water and milk, they have increased their consumption of fruits and vegetables and they have increased their level of physical activity. Furthermore, the BMI (Body Mass Index) profile of the Project L.E.A.N. students is better than all other classes at Jefferson.

Project L.E.A.N. stemmed from a desire to combat the national obesity crisis, starting on a local level. National and local statistics reveal a dire need for change:

Jefferson Elementary was chosen as a pilot school for the program because it is the largest elementary school in Norwalk, serves the largest minority population (83%) of elementary schools in Norwalk, and has a large population of children who receive free or reduced rate lunchesan indicator of financial need.

Pepperidge Farm is proud to be one of the founding sponsors of Project L.E.A.N. Its an innovative approach to combating childhood obesity and could not have gotten off the ground without the partnership between the hospital, school, health department and the business sector, said Walsh. In particular, the principal at Jefferson School, John Reynolds, and the teachers deserve much of the credit for this programs success. From the very beginning, everyone including the students, teachers, parents and partners embraced the Project L.E.A.N. approach to improve the childrens health.

Project L.E.A.N. will start up again in the fall at Jefferson School, but in the meantime, the students will be invited to attend three Project L.E.A.N. Summer festivities, keeping everyone in tip-top shape for the fall.

About Pepperidge Farm

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Project L.E.A.N. Childhood Obesity Prevention Program Shows Excellent Results at the End of Its Second Year

The science of training and development in organizations: What really matters, what really works

Each year in the United States about $135 billion is spent in training employees but those billions do not always improve the workplace because the skills often do not transfer to the actual job.

"Learning is a way of life in organizations," says Eduardo Salas, a psychological scientist from the University of Central Florida. "Everyone gets training. But what matters? What works? What influences learning and skill acquisition?"

In a new report published in Psychological Science in the Public Interest, a journal of the Association for Psychological Science, Salas and co-authors conclude that when this money is well spent, "training and development activities allow organizations to adapt, compete, excel, innovate, produce, be safe, improve service and reach goals."

One of the most important things that "matters", the researchers found in their survey of the vast scientific literature on the science of training, is that human resource executives, chief learning officers and business leaders should view training as a whole system and not a one-time event. This means that what happens before and after the actual training are just as important as the training itself.

Training is especially effective when various jobs in the organization have been analyzed, the skill sets of its employees are understood, supervisors and leaders are all on the same page and trainees are motivated to learn. During the training, whether it is computer and technology based or in a classroom, sufficient structure and guidance should be offered to trainees while still giving them opportunities to make decisions about their learning experience. After the training, trainees should have ample time and opportunities to use what they have learned in the real world with real feedback.

The individual characteristics that trainees bring to a learning environment are especially important to consider when implementing training programs. Research shows that trainees who believe that their abilities actually influence training outcomes are more likely to persist in learning activities, even when they encounter challenges. And psychological science has also shown that trainees who are oriented toward mastery or learning may perform better when they can control how they explore and organize training material, whereas trainees who are oriented toward performance seem to do better in highly structured environments that involve successively more complex tasks.

The broader psychological science of learning can also inform effective training programs. Research shows that a gap exists between performance in training and the integration of newly learned skills on the job. But that gap can be narrowed through the application of various empirically tested insights into learning. For example, repeating tasks within increasingly complicated contexts helps to ensure that learning lasts over time. Furthermore, encountering errors during training helps to prepare trainees for real-life situations as they are required to apply concepts learned in training. Finally, watching someone else perform certain skills can also contribute to learning, a concept scientists refer to as behavioral role modeling.

Despite the wealth of practical and scientific research in this field, as Paul W Thayer, professor of psychology from North Carolina State University in Raleigh points out in his commentary accompanying the article, "There is still a tendency in business, government, and academia to adopt programs based on little more than attractiveness, modishness, or a desire to keep up with others in the field."

Salas and his colleagues have tips for policymakers, too, who may need to assess skills across an entire country or geographic region, and whose goals are more likely to include skills that are relevant to many jobs to ease employee transfers. Establishing a well-prepared labor pool can help to attract businesses, provide jobs, and increase competitiveness in a given area or industry. With this in mind, the authors emphasize that "government should not be promoting or investing in training efforts that fail to incorporate the principles of good training."

Policymakers can use the best practices of training evaluation to scrutinize funded training programs for inefficiencies and determine whether those programs still merit funding.

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The science of training and development in organizations: What really matters, what really works

Attention Doctors: Is Personalized Healthcare the Answer to Your Practice Woes? Find Out at Upcoming Seminar

LAS VEGAS, June 12, 2012 /PRNewswire/ --While many doctors continue to struggle with stagnant or decreasing revenues, long wait times for patients and the frustration that comes with dealing with medical insurance companies, others are saying personalized healthcare has helped turned their practices around.

Find out if personalized healthcare is right for you at a unique session for medical professionals that will be held immediately following the open to the general public "Live Better, Longer Optimal Health and Wellness withHormones, Nutrition and Preventive Medicine" Seminar, Saturday, June 16, from 11-noon at Life Time Athletic 10721 W. Charleston Blvd. Summerlin, NV 89135 Third Floor Conference Room.

During the special follow-up session, Dr. Michael S. Mall, Personalized Health Care, will explain why he, and many other experts, believe personalized health care is the future of medicine in the United States.

"Personalized healthcare provides doctors with an easier business model to reach out to patients with personalized and preventative healthcare," Mall said. "In fact, studies have shown that patients receiving personalized healthcare make, on average, 65% less hospital visits than patients receiving traditional medical care."

Mall said personalized healthcare offers a number of benefits for both patients and doctors. For example, patients enjoy:

Meanwhile, physicians get steady monthly revenue that ranges from $1,500 to $2,200 per patient and that includes a 90% yearly renewal rate.

Session attendees will learn how to take advantage of the growing personalized healthcare trend to organize their practice in a way that increases sales and profits while allowing them to provide improved patient care.

They'll also learn how to increase gross sales by over $1 million in just one year; receive financial tips from a Wells Fargo banker who specializes in helping medical practices; learn how to start using age management programs to send sales soaring; and much more.

In addition, the follow-up session will include more information on hormone therapy and how it in particular and anti-aging/age management programs in general can help increase a practice's profits.

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Attention Doctors: Is Personalized Healthcare the Answer to Your Practice Woes? Find Out at Upcoming Seminar

Anatomy of an aftermath: Movie being planned about Melinda Elkins Dawson

It probably is assumed by most people that Melinda Elkins Dawsons story had a definitive end.

In June of 1998, Dawsons mother, Judith Johnson of Barberton, was raped and murdered. A

6-year-old niece also was attacked and raped. Dawsons then-husband, Clarence Elkins, was charged with the crimes, based on the childs account to police.

After Clarence Elkins went to prison, Dawson took it upon herself to prove his innocence, an effort that took seven years.

Clarence Elkins eventually was able to surreptitiously acquire DNA evidence via a cigarette butt from Earl G. Mann, Johnsons former neighbor, who also happened to be imprisoned with Elkins. It matched DNA found at the crime scene. Mann eventually pleaded guilty.

After Elkins was exonerated and released from prison in 2006, he reached a $1.075 million settlement with the state. In 2010, the Elkins family settled a $5.25 million federal lawsuit against the Barberton Police Department. A suit against the Summit County Prosecutors Office was dismissed.

Dawsons life story recently was optioned by movie producer/screenwriter David Massar, who said a script is in development. Massar said he would like to shoot parts of the film in Barberton, Akron and the Magnolia area. The Elkinses were living outside of Magnolia in Carroll County when Clarence Elkins was arrested. The couple divorced in 2007.

TAX FIGHT

But these days, Dawson is fighting a different battle, this one with the Internal Revenue Service, which has informed her that she owes taxes on her share of the compensation money received from the federal suit.

We should not have to fight for something that was rightfully awarded to my sons, myself, and Clarence, she said. There needs to be an amendment to the federal tax law that will cover this subject, not only for my family but for the countless other families that will face this issue one day.

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Anatomy of an aftermath: Movie being planned about Melinda Elkins Dawson

Grey's Anatomy Star Eric Dane and Rebecca Gayheart Talk Kids—and the Show's Finale Surprise

Dane, 39, and Gayheart, 40, say Billie is finally warming up to little Georgina.

"Billie is being a great big sister now," Gayheart gushed to us at the Chrysalis Butterfly Ball in L.A.

"We've had a couple rough patches but she really adores her," she said. "She's really sweet. It's like her live baby doll."

That means Billie is getting more hands-on with mom and dad's baby duty.

"She helps change her diaper and give her food and put her bib on," Gayheart said, adding, "but sometimes she regresses and wants the pacifier for herself."

Meanwhile, Dane dished his thoughts about Grey's Anatomy's shocking season eight finale in which costar Chyler Leigh was surprisingly killed off.

"I wasn't [shocked] because I knew that Chyler wanted to spend some more time with her family," Dane said. "It's a tough schedule to keep up and she's been working on the show for five seasons. So I wasn't shocked. A little surprised but not shocked. We're going to miss her."

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Grey's Anatomy Star Eric Dane and Rebecca Gayheart Talk Kids—and the Show's Finale Surprise

Anatomy of a Successful PPC Ad

So much technical work goes into your online marketing that you may get lost in the minutiae. Sometimes its easy to forget that creative advertising still matters.

A great example: ad copywriting, which plays a crucial factor in your companys success. Nowhere is this more evident than in PPC advertising, where you have little time to capture the attention of a potential customer.

Stop dwelling on audience targeting and all of the technical settings you can use. Its far more important to write ad copy that resonates with your customers.

Understanding the elements of a successful PPC ad include will:

There are five important PPC ad copy elements that will affect your prospects decision to take action and click through on your ad, and then once on your page to convert to a customer.

Your potential visitor is looking for a solution to their pain points. In fact, customers care about solving their problem, not necessarily buying your product. You must convince them that you will solve those pain points (support, new products, and services).

Saving money is a huge perceived value. Everyone wants to save money by finding a cheap way to solve their problem (or even better, solve the problem free of cost!). Your ad copy should emphasize what problem youll be solving for the user.

While your customers want to solve their problem, they also want to guard against the risk of wasting time and money. This is why risk reversal is such an important element of your ad copy.

To help users guard against risk, you must convince them of the value of clicking on your ad and not wasting time by getting suckered in to something that doesnt work for them.

At every step of the way, you want to reduce the friction of taking the next step. Convince users of the value of clicking on your ad, and you will get more relevant visitors.

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Anatomy of a Successful PPC Ad

Bye Bye Birdees Consulting Services, LLC Becomes Part of the Global Travel Organization

Benicia, CA (PRWEB) June 13, 2012

Bye Bye Birdees Consulting Services,LLC , based in Benicia, CA , announced today that it has become a part of NEST (Network of Entrepreneurs Selling Travel), a travel organization that includes the most knowledgeable travel consultants and top travel suppliers in the world today.

The dedicated consultants at Bye Bye Birdees arrange travel experiences for both vacationers and business travelers that best fit their needs and budgets. They have strong relationships with the crme de la crme of travel suppliers, the companies that consumers most know and trust -- including cruise lines, tour operators, hotels, airlines and car rentals. And, they make personal recommendations drawing on their own travels.

Because Bye Bye Birdees belongs to the NEST group (and is affiliated with its international parent company American Marketing Group, Inc.), they have access to the finest vacation products around the world that are among the lowest prices in the marketplace. In addition, the agency can tap into a network of partners on virtually every continent that provides local travel knowledge, insights and in-country personal assistance.

Bye Bye Birdees is also perfectly positioned to help corporations better manage their global travel spend while providing them with unparalleled personal service in key markets worldwide. The agency offers business clientele a global preferred rate hotel program featuring over 96,000 negotiated hotel rates in 124 countries; a policy-compliant corporate self-booking tool; and a travel data consolidation tool to help control travel expenditures.

Juliet Vercelli of Bye Bye Birdees commented about why they chose to join NEST and the benefits to their customers: "At Bye Bye Birdees, we confidently meet the varied needs of all types of travelers, in part because our affiliation with NEST provides us with the relationships, resources, technology and opportunities that we, in turn, pass along to our clientele. Wherever in the world our clients want to go, we can get them there at price points that deliver great value. There are tremendous travel values available right now. So, the most important question is: where do you want to go next?"

Bye Bye Birdees Consulting Services, LLC was established February 4, 2010 featuring a small team of travel professionals. The company specializes in group travel specifically destination weddings, reunions and any major milestone in a destination. All members are tenured in world wide travel keeping abreast of the latest hotspot destinations. Education and Certifications are important to include up to date information on tour operators, destinations and upcoming travel interests such as Space Tourism, Honeymoons and Destination Weddings, and Sustainable Tourism.

"We're pleased to welcome Bye Bye Birdees Consulting Services, LLC to NEST," said Kathryn Mazza-Burney, President of NEST. "We're very selective in our process of identifying and inviting travel advisors to become part of our organization. They are among the very best travel consultants available today, and they are standing by ready to serve travelers with the personal touch that they expect and deserve. We encourage travelers to call the agency and take advantage of the incredible deals and unforgettable experiences they offer."

Contact: Juliet Vercelli 707-313-3113 Juliet(at)byebyebirdees(dot)com

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Bye Bye Birdees Consulting Services, LLC Becomes Part of the Global Travel Organization

Budapest, Hungary The Top European Bargain This Summer; London Crowned The Costliest For American Travelers

NEWTON, Mass., June 13, 2012 /PRNewswire/ -- TripAdvisor, the world's largest travel site*, today announced TripIndex 2012 a cost comparison of accommodations and an evening out on the town for two people in popular tourist cities across the United States and throughout the world.

To view the multimedia assets associated with this release, please click: http://www.multivu.com/mnr/49269-tripadvisor-tripindex-top-global-and-domestic-steals-and-splurges

(Photo: http://photos.prnewswire.com/prnh/20120613/MM22781)

(Logo:http://photos.prnewswire.com/prnh/20080902/TRIPADVISORLOGO)

The TripAdvisor TripIndex is based on the combined costs for two of a one-night stay in a four-star hotel, one cocktail per person, a two-course dinner with a bottle of wine, and round-trip taxi transportation (two journeys of two miles).

The costs listed apply to the upcoming summer months (June 1 August 31, 2012).

Global Travel Steals

Expensive Escapes

Southern Hospitality

For the second year, TripIndex reveals the Southern U.S. as the top region for travelers looking for domestic deals. The South features four of the top 10 most affordable U.S. destinations on the TripIndex: Dallas, New Orleans, Atlanta and Orlando, all with total prices between $283 and $309.

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Budapest, Hungary The Top European Bargain This Summer; London Crowned The Costliest For American Travelers

Passports with Purpose Partners With Expedia.com for Annual Travel Bloggers Fundraiser

BELLEVUE, WA--(Marketwire -06/13/12)- Passports with Purpose (PwP) today announced that Expedia.com, the world's leading online travel agency, will join thousands of travel enthusiasts in the annual travel bloggers community fundraiser as the platinum sponsor. In its fifth year, Passports with Purpose co-founders Beth Whitman, Pam Mandel, Michelle Duffy and Debbie Dubrow will announce the 2012 beneficiary at the Expedia Summer Shindig party at the Travel Blog Exchange (TBEX) in Colorado on June 16 at 7:00 pm (MDT).

Each year Passports with Purpose has surpassed its fundraising goal through the support of sponsors, and a network of travel bloggers and individual donors, leading to the creation of two libraries in Zambia, a school in Cambodia and a village in India. The 2012 philanthropic effort will begin November 27, 2012 and end December 11, 2012 on http://www.PassportswithPurpose.org.

Expedia.com also supported Passports with Purpose as its official travel sponsor for co-founders Beth Whitman, Debbie Dubrow and Michelle Duffy for their visit to one of the two Room to Read libraries in Zambia.

"The bloggers behind Passports with Purpose are a perfect example of how travel can inspire us to find our passions and our purpose," said Joe Megibow, Vice President and General Manager, Expedia.com. "We're thrilled to be partnering with these bloggers to change another pocket of the world this year."

"We're delighted to have Expedia support Passports with Purpose this year. We feel that together, we can create strong momentum to make the 2012 fundraiser the most successful and broad-reaching effort to date," said Beth Whitman.

"This year, our relationship with Expedia allows us to expand our reach in ways we never thought we'd be able. Their global support gives us the opportunity to grow our audience in ways we couldn't have done on our own," said Pam Mandel. "A bigger audience means more participation, and more participation means that, working with causes we believe in, we can make an even bigger difference in the world. Passports with Purpose and Expedia share in the vision that travel has the power to change the world."

During the fundraiser, participating bloggers procure a prize, post about Passports with Purpose and the prize on their blog, and promote the fundraiser in social media and among their network of contacts. Past prizes included vacation packages, electronics and gear and amazing travel experiences. The Passports with Purpose website hosts a list of all the available prizes and donors make a tax-deductible donation. For each $10 donated, eligible donors will be entered to win a prize of their choice. After the fundraiser ends, a winner is randomly selected for each prize. All of the funds raised go to the chosen beneficiary.

About Passports with PurposeIn 2008, Debbie Dubrow, Michelle Duffy, Pam Mandel and Beth Whitman, the bloggers behind Delicious Baby, WanderMom, Nerd's Eye View and Wanderlust and Lipstick, respectively, began a travel-inspired initiative to raise money online. Passports with Purpose also filled the need to do long-lasting good for people in the places travelers visit by uniting an online community and leveraging the social media platforms of more than 100 travel bloggers around the world. PwP initiatives benefited Heifer International; the Passports School with American Assistance for Cambodia and a village in Tamil Nadu, India for 25 Dalit families with Land for Tillers' Freedom. In 2011, funds were raised to build two libraries in Zambia with Room to Read. For more information about Passports with Purpose visit, http://www.PassportswithPurpose.org, http://www.Facebook.com/PassportswithPurpose or http://www.Twitter.com/PassportPurpose.

About Expedia.comExpedia.com is the world's leading online travel site, helping millions of travelers per month easily plan and book travel. Expedia.com (http://www.expedia.com/ 1-800-EXPEDIA) aims to provide the latest technology and the widest selection of vacation packages, flights, hotels, resorts, rental cars, cruises and in-destination activities, attractions, and services. With the Expedia Best Price Guarantee, Expedia.com customers can get the best rates available online for all types of travel.

2012 Expedia, Inc. All rights reserved. Expedia, Expedia.com and the Airplane logo are either registered trademarks or trademarks of Expedia, Inc. in the U.S. and/or other countries. Other logos or product and company names mentioned herein may be the property of their respective owners. CST # 2029030-50

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Passports with Purpose Partners With Expedia.com for Annual Travel Bloggers Fundraiser

Super Computer for Sale – Video

12-06-2012 19:45 Antec LANBOY air i7 2600k 3.4 (4.5 overclocked) Asus Sabertooth TUF edition P67 Motherboard 2x 590 GTX Quad Sli 3GB memory Cooler Master V10 TEC cooler 16 gb of corsair memory 1600 mhz and about 3.5 TB of hard drive space It sports a total of 1024 CUDA processing cores, 128 texture units, 96 ROP units, and 32 tessellation engines for making the most of one of the most sought-after DirectX 11 (DX11) features. The card's graphics clock runs at 607 MHz, its processor clock at 1215 MHz, and its memory clock at 3414 MHz. It's loaded with 3072MB of GDDR5 memory for the frame buffer, which operates over a 384-bit memory interface. CONTACT FOR MORE DETAILS AND HD PHOTOS.

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Super Computer for Sale - Video

Abunda to try stem cell therapy for mom

MANILA, Philippines -- "The Buzz" host Boy Abunda is going to Europe this weekend with his mother, who is suffering from dementia and Alzeimers disease.

In an interview with ABS-CBN News on Tuesday afternoon, Abunda said he will bring his mother to Germany to try stem cell therapy.

"Ako ay pupunta sa Europe hindi para magbakasyon. Dadalhin ko po ang aking ina para magpagamot sa Germany. Ito po 'yung fresh stem cell therapy. Maganda 'yung dini-diretso na dahil napag-uusapan ito," Abunda said.

While Abunda is in Germany, Kris Aquino will take his place on ABS-CBN's entertainment talk show "The Buzz."

In the interview, Abunda also said he's proud of Aquino, who's now open to doing extreme adventures, while continuing to be a good mother to her two sons.

"Ang daming nagbago kay Kris. May mga bagay na hindi ko inakala na gagawin ni Kris like 'yung diving, zipline at marami pang iba. Natutuwa ako that she has become more open to many things. She has become more adventurous. She has retained being the doting mother that she is pero mas malalim ang halakhak niya ngayon sa buhay. She's just so joyful. Natutuwa ako habang pinapanood ko ang kanyang adventure sa 'KrisTV,'" Abunda said.

Abunda said he's also hoping to do a new project with Aquino.

"I'm hoping na someday ay muli kaming magtagpo sa isang palabas dahil marami ang humihiling na kami ay magsama sa isang palabas. Sigurado ako sa puso ko na kami ay gagawa at gagawa dahil magkadugtong ang aming pusod," he said.

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Abunda to try stem cell therapy for mom

New Applications in Drug Discovery Platforms to Fuel Advance of Stem Cells, Says Frost & Sullivan

Ethical, Clinical and Commercial Issues to be Navigated before Full Potential of Stem Cell Therapies can be Unleashed

LONDON, June 13, 2012 /PRNewswire-Asia/ -- Stem cells offer exciting potential in regenerative medicine, and are likely to be widely used by mid-2017. Pharmaceutical, biotech and medical device companies are showing increased interest in stem cell research.

New analysis from Frost & Sullivan (http://www.pharma.frost.com), Analysis of the Stem Cell Markets-Unlocking the New Era in Therapeutics, finds that the market will be driven by stem cell applications in drug discovery platforms and by successful academia commercial company partnership models.

"The high attrition rates of potential drug candidates has piqued the interest of pharmaceutical and biotech industries in stem cell use during the drug discovery phase," notes Frost & Sullivan Consulting Analyst Vinod Jyothikumar. "Previously, animal cell lines, tumours, or genetic transformation have been the traditional platform for testing drug candidates; however, these 'abnormal' cells have significantly contributed to a lack of translation into clinical studies."

Many academic institutes and research centres are collaborating with biotechnology and pharmaceutical companies in stem cell research. This will provide impetus to the emergence of novel cell-based therapies.

Key challenges to market development relate to reimbursement, ethics and the complexity of clinical trials.

Securing reimbursement for stem cell therapeutic products is expected to be critical for commercial success. However, stem cell therapies are likely to be expensive. Insurers, therefore, may be unwilling to pay for the treatment. At the same time, patients are unlikely to be able to afford these treatments.

"The use of embryonic stem cells raises a host of thorny ethical, legal, and social issues," adds Jyothikumar. "As a result, market prices for various products may be affected."

Moreover, many research institutes are adopting policies promoting the ethical use of human embryonic tissues. Such policies are hindering the overall research process for several companies working in collaboration with these institutes.

"In addition to apprehensions about how many products will actually make it through human-based clinical trials, companies are also worried about which financial model can be applied to stem cell therapies," cautions Jyothikumar. "Possibly low return on investment (ROI) is also resulting in pharmaceutical companies adopting a cautious approach to stem cell therapeutics."

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New Applications in Drug Discovery Platforms to Fuel Advance of Stem Cells, Says Frost & Sullivan

Scientists see new hope for restoring vision with stem cell help

This is a human ES cell-derived optic cup generated in our self-organization culture (culture day 26). Bright green, neural retina; off green, pigment epithelium; blue, nuclei; red, active myosin (strong in the inner surface of pigment epithelium). Credit: Nakano et al. Cell Stem Cell Volume 10 Issue 6

Human-derived stem cells can spontaneously form the tissue that develops into the part of the eye that allows us to see, according to a study published by Cell Press in the 5th anniversary issue of the journal Cell Stem Cell. Transplantation of this 3D tissue in the future could help patients with visual impairments see clearly.

"This is an important milestone for a new generation of regenerative medicine," says senior study author Yoshiki Sasai of the RIKEN Center for Developmental Biology. "Our approach opens a new avenue to the use of human stem cell-derived complex tissues for therapy, as well as for other medical studies related to pathogenesis and drug discovery."

During development, light-sensitive tissue lining the back of the eye, called the retina, forms from a structure known as the optic cup. In the new study, this structure spontaneously emerged from human embryonic stem cells (hESCs)cells derived from human embryos that are capable of developing into a variety of tissuesthanks to the cell culture methods optimized by Sasai and his team.

The hESC-derived cells formed the correct 3D shape and the two layers of the optic cup, including a layer containing a large number of light-responsive cells called photoreceptors. Because retinal degeneration primarily results from damage to these cells, the hESC-derived tissue could be ideal transplantation material.

Beyond the clinical implications, the study will likely accelerate the acquisition of knowledge in the field of developmental biology. For instance, the hESC-derived optic cup is much larger than the optic cup that Sasai and collaborators previously derived from mouse embryonic stem cells, suggesting that these cells contain innate species-specific instructions for building this eye structure. "This study opens the door to understanding human-specific aspects of eye development that researchers were not able to investigate before," Sasai says.

The anniversary issue containing Sasai's study will be given to each delegate attending the 2012 ISSCR meeting in Yokohama, Japan. To highlight the ISSCR meeting and showcase the strong advances made by Japanese scientists in the stem cell field, the issue will also feature two other papers from Japanese authors, including the research groups of Akira Onishi and Jun Yamashita. In addition, the issue contains a series of reviews and perspectives from worldwide leaders in stem cell research.

More information: Nakano et al.: "Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs." DOI 10.1016/j.stem.2012.05.009

Journal reference: Cell Stem Cell

Provided by Cell Press

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Scientists see new hope for restoring vision with stem cell help

Lockheed Martin Advanced Technology Center Delivers Flight Hardware For NASA's Magnetospheric Multiscale Mission

PALO ALTO, Calif., June 13, 2012 /PRNewswire/ --Engineers and scientists at the Lockheed Martin [NYSE: LMT] Space Systems Advanced Technology Center (ATC) have completed delivery of key hardware subsystems for NASA's Magnetospheric Multiscale mission (MMS). The delivery comprised four flight subsystems and one flight spare unit. The prime contractor Southwest Research Institute (SWRI) partnered with Lockheed Martin to develop and build the Hot Plasma Composition Analyzer (HPCA) as part of the MMS instrument suite.

When it launches in 2014, the MMS mission will provide unprecedented insights into a little-understood physical process at the heart of all space weather. This process, known as magnetic reconnection, sparks solar flares, coronal mass ejections, and other phenomena that can imperil Earth-orbiting spacecraft and terrestrial power grids. High-resolution data from MMS will provide researchers much greater clarity into the mechanisms involved in magnetic reconnection and associated phenomena.

"Magnetic reconnection at the Earth's magnetopause is the mechanism by which magnetic fields in different regions in this case, from the Interplanetary Magnetic Field (IMF) carried by the solar wind, and the Earth's magnetic field change topology to open magnetospheric field lines. This connection allows energy and momentum to flow from the solar wind into the magnetosphere," said Dr. Karlheinz Trattner, Lockheed Martin ATC space plasma physicist, and co-investigator on MMS.

The MMS mission is a Solar Terrestrial Probes mission comprising four identically instrumented spacecraft that will use Earth's magnetosphere as a laboratory to study the microphysics of magnetic reconnection and two other fundamental plasma processes: energetic particle acceleration, and turbulence. These processes have implications for many space science research areas since they occur in all astrophysical plasma systems but can be studied in situ only in our solar system and most efficiently only in Earth's magnetosphere, where they control the dynamics of the geospace environment and play a significant role in space weather.

The four satellites of the MMS mission will be deployed in an orbit to skim the boundary layer between the magnetosphere and the interplanetary magnetic field where magnetic reconnection is known to exist.The MMS spacecraft are being developed at NASA's Goddard Space Flight Center (GSFC) in Greenbelt, Maryland. GSFC is also responsible for the overall management of the MMS mission and mission operations.

The ATC is the research and development organization of Lockheed Martin Space Systems Company (LMSSC) and creates the technology foundation for the company's business. In addition, the ATC conducts basic research into understanding and predicting space weather and the behavior of our Sun, including its impacts on Earth and climate. It has a five-decade-long heritage of spaceborne instruments.

LMSSC, a major operating unit of Lockheed Martin Corporation, designs and develops, tests, manufactures and operates a full spectrum of advanced-technology systems for national security and military, civil government and commercial customers. Chief products include human space flight systems; a full range of remote sensing, navigation, meteorological and communications satellites and instruments; space observatories and interplanetary spacecraft; laser radar; ballistic missiles; missile defense systems; and nanotechnology research and development.

Headquartered in Bethesda, Md., Lockheed Martin is a global security and aerospace company that employs about 123,000 people worldwide and is principally engaged in the research, design, development, manufacture, integration and sustainment of advanced technology systems, products and services. The Corporation's net sales for 2011 were $46.5 billion.

Media Contact: Buddy Nelson, (510) 797-0349; e-mail, buddy.nelson@lmco.com

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Lockheed Martin Advanced Technology Center Delivers Flight Hardware For NASA's Magnetospheric Multiscale Mission