HCCC’s renovated science labs ‘amazing’

Bonita Gibb hovered over a new microscope examining a piece of cardiac muscle. While the Herkimer County Community College student did not take science classes prior to construction of the $2.8 million laboratory renovation project, she is benefiting from the better organized, high-technology equipped, spacious and cheery classrooms at the college. Fifty percent of the cost of renovations was matched by the state, while the other half is being funded by donations. For about two weeks, students and faculty have enjoyed the refurbished science labs in the Edward Manning and Shirley Angar Gaynor Science Center. Last week, biology Professor Jennifer Herzog wrote on a white-painted portion of the wall which serves as a white board in the front of the microbiology lab as a few of her students analyzed microbes. Its amazing. Its so much more spacious, she said. Im finally able to get everything taught with students working in a safe environment. Herzog said students and faculty were impressed with the renovations, and noted she can see all her students as they work. We had the ahh factor when we opened the door, she said. During the planning process, faculty was asked for their opinions on what should be included in each of the specific labs microbiology, chemistry, biology, physics and anatomy. Each room is equipped with 24 stations. From new microscopes, computers and touch-screen televisions to clear cabinets for easily finding tools, the five labs were designed with everyone in mind. It was everything I asked for down to the pull-out drawers, Herzog said as she pulled a wooden slab hidden within one of the stations. The new labs also means the college will be able to offer more classes as well as new programs down the line, said Henry Testa, associate dean of academic affairs for business, health, science and technology. Down the hall, physics and astronomy Professor Faith Thompson said her request was for plenty of outlets. Plenty, where theyre not dangerous, she said, noting the stations are large enough to fit the equipment now and dont bulk under the weight. Theyre stable for vibrations, Thompson said. Second-year student Jennifer Canter, who sat in Thompsons lab room, said the old labs made it difficult to work in groups. Compared to the old labs, (these) are more functional and easier to get around in, she said.

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HCCC’s renovated science labs ‘amazing’

DNA evidence fails to convince jury of man’s guilt in 1983 killing

A retrial is expected in a San Francisco cold case murder in which DNA evidence failed to lead to a conviction Tuesday.

Just three of the 12 jurors believed there was enough evidence even after matching DNA samples to convict 48-year-old William Payne of strangling to death 41-year-old Nikolaus Crumbley while raping him in a car in John McLaren Park on Nov. 16, 1983.

On Wednesday, Deputy Public Defender Kwixuan Maloof, who represents Payne, said the hung jury proves that despite what we see on television, the presence of DNA does not prove a person is guilty of a crime.

But prosecutors appear determined to prove otherwise. Motions in Paynes retrial begin today, the Public Defenders Office said, with opening arguments scheduled for Oct. 22.

DNA evidence and independent corroborating testimony linked the defendant to the brutal rape and murder of Mr. Crumbely, District Attorney George Gascn said following Tuesdays outcome.

Payne was 19 years old when Crumbleys body was found facedown at the intersection of John Shelley Drive and Mansell Street. Prosecutors said Crumbleys pants and underwear were pulled down to his ankles.

Prosecutors believe Payne killed Crumbley while the two were having sex in Crumbleys rental car, which was later found in Oaklands Lake Merritt.

Three years ago, cold case investigators tied DNA found in Crumbleys rectum to Payne, whose DNA had been entered in a criminal database after he assaulted a woman in 1984.

In January, Payne was charged with first-degree murder during the course of sodomy.

But the DNA evidence wasnt enough to convince nine jurors of Paynes guilt.

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DNA evidence fails to convince jury of man’s guilt in 1983 killing

Posted in DNA

RainDance Technologies and Integrated DNA Technologies to Develop Reagents and Consumables for Digital PCR

LEXINGTON, Mass. & CORALVILLE, Iowa--(BUSINESS WIRE)--

RainDance Technologies, Inc., the Digital Biology Company, and Integrated DNA Technologies (IDT) Inc., the world leader in oligonucleotide synthesis, today announced a collaboration focused on consumables specifically tailored to perform the fast-growing application of digital PCR. Under the terms of the agreement, the companies will work together on the development of reagents compatible with the RainDrop Digital PCR System. Financial terms of the agreement were not disclosed.

The RainDrop Digital PCR System is a breakthrough research platform that is transforming the performance of molecular assays by enabling digital answers across a number of important applications including low-frequency tumor allele detection, gene expression, copy number variation, and SNP measurement. Built using RainDances proven RainStorm picodroplet technology, the RainDrop System generates up to 10 million picoliter-sized droplets per sample. Since each droplet encapsulates no more than a single molecule, researchers can quickly determine the absolute number of droplets containing specific target DNA and compare that to the number of droplets with background, wild-type DNA.

We have achieved a new gold standard in sensitivity, quantitation and multiplexing through enhancements in every aspect of system and reagent refinement, said Rena McClory, Ph.D., Marketing Director for Digital PCR at RainDance Technologies. We are pleased to be working with market leaders such as IDT on the development and broad availability of best-in-class reagents in support of our new RainDrop Digital PCR System.

IDT is a leader in manufacturing and developing custom oligonucleotideproductsfor use in the research and diagnostic life science markets.This includesdesign and synthesis ofdual-labeled probes for gene expression and genotyping as part of the PrimeTime qPCR product family. Founded by Dr. Joseph Walder in 1987, IDTs development has been guided by an uncompromising approach to quality, a belief in the value of good service, and a determination to minimize consumer costs.

We are pleased to be working with RainDance in supporting scientists who are seeking to apply the powerful attributes of digital PCR to their research projects, said Stephen Gunstream, Senior Vice President of Marketing and Strategy at IDT. Digital PCR is redefining the science of directly quantifying and amplifying nucleic acids and will open the doors to an exciting era of new discoveries.

For more information about the RainDrop Digital PCR System, please visit http://www.RainDanceTech.com.

About RainDance Technologies

RainDance Technologies, the Digital Biology Company, is pioneering the use of high-throughput picodroplet-based analysis in human health and life science research. The company's core RainStorm technology generates millions of discrete droplets that can encapsulate a single molecule, cell or reaction and be digitally analyzed and sorted one at a time. The power, precision and simplicity of picodroplets enable researchers to answer complex questions with unprecedented sensitivity and quantitation. The complete RainDance solution includes automated instrumentation, customizable bioinformatics and high-value consumables and reagents for applications including targeted next-generation DNA sequencing, methylation, digital PCR. Based in Lexington, Massachusetts, the company supports scientists around the world through its international sales and support operations and a global network of distributors and service providers. For more information, please visitwww.RainDanceTech.com.

For research use only. Not for use in diagnostics procedures.

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RainDance Technologies and Integrated DNA Technologies to Develop Reagents and Consumables for Digital PCR

Posted in DNA

Leonard Lerman, 87; senior lecturer at MIT researched DNA

Using tools he often had made himself, Leonard Lerman took great care in making precise measurements during experiments he performed to further the understanding of DNA.

A simple way to state it is that he was a deeply quantitative man, said Tom Maniatis, chairman of the biochemistry and molecular biophysics department at Columbia University, who had worked with Dr. Lerman as a graduate student at Vanderbilt University.

Discoveries he made about what can unwind the strands of DNA, and other research throughout his career, helped Dr. Lerman become a key figure in the field of molecular biology.

He was both a deep and brilliant man, and also a clever man, in the sense that he always had great ideas and techniques, Maniatis said.

Dr. Lerman, formerly a senior lecturer at the Massachusetts Institute of Technology, died Sept. 19 in his Cambridge home of a chronic neurological disease. He was 87.

He did lots of things that served for the increased understanding of the structure of DNA and the things that interacted with DNA, said Maurice Fox, a professor emeritus of molecular biology at MIT.

Dr. Lerman, Maniatis said, saw the world through mathematics and could use mathematical and physical properties of molecules to predict what would occur.

As a graduate student at the California Institute of Technology, Dr. Lerman worked with Linus Pauling, who in 1954 was awarded the Nobel Prize for chemistry and has often been referred to as one of the founders of molecular biology.

Dr. Lerman set out to prove his hunch that antibodies have two binding sites to bond with antigens, which are any foreign substances that prompt an immune response. After achieving that goal, he graduated from Cal Tech with a doctorate in chemistry in 1950 and went on to join the faculty of the University of Colorado.

The 1950s were an active time for DNA research. Dr. Lerman was determined to find out more about chemicals that attach to DNA strands and make them unwind, often causing mutations. The way certain chemicals attach to the strands is called intercalation, and it occurs between adjacent base pairs in double-stranded DNA.

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Leonard Lerman, 87; senior lecturer at MIT researched DNA

Posted in DNA

The Future of DNA Sequencing Isn't in the Lab

Up until now, the money Illumina (Nasdaq: ILMN) , Roche, Life Technologies (Nasdaq: LIFE) , and Pacific Biosciences of California (Nasdaq: PACB) have made selling DNA sequencers has come from research labs. Academics need DNA sequencers to do basic research to understand how genetic variation affects biologic processes.

That basic research has translated into the clinic at an alarming rate, producing the next generation of DNA sequencing demand.

You can see it in the acquisitions Roche's bid for Illumina appeared to be mostly driven by bringing sequencing to the clinic. Roche has a strong hold in diagnostic testing, and Illumina's sequencing technology is superior to Roche's. But Roche played hardball and didn't want to overpay for the technology.

Last month, Illumina decided it could fill some of the gap on its own, purchasing BlueGenome, a leader in cytogenetics. The company sells tests that look at the DNA to identify genetic abnormalities that lead to cancer and other issues. Currently, those abnormalities are identified by binding probes to the DNA to identify duplications and fusion of chromosomes, but we're not too far off from where cancer patients just routinely get their DNA sequenced to identify the abnormalities.

Blue Genome also has a test to look for abnormalities before in vitro fertilization. Sequencing might be harder there, because of less DNA, but these issues are often overcome eventually.

It sure looks to me like Illumina bought BlueGenome more for its ability to sell and run the clinical test than for the test themselves, which may be obsolete in a few years given the rapid decrease in the cost of sequencing. We will get to the point where running individual tests like Sequenom's (Nasdaq: SQNM) MaterniT21 PLUS will be silly because the entire genome can be analyzed for the same cost.

Diagnosing Earlier this month, Life Technologies hooked up with CollabRx (Nasdaq: CLRX) to use the company's interpretive analytics to help develop tests for cancer diagnostics. CollabRx combines a patient's data from multiple sources to help the doctor develop a treatment plan. The genotype of a tumor tells you a lot about what drugs might be able to kill the tumor, but the genetic variation still needs to be taken in context with other pieces of information.

Getting the sequence and knowing what to do with it are two different things. One startup sequencing company, Knome, has begun selling a $125,000 supercomputer, so hospitals can analyze patients' DNA sequences directly. Having the process in-house might speed up diagnosis, but the appeal seems to also be about avoiding confidentiality issues for the patients when the data is shared externally. Either way, the fact that hospitals are buying the station is a sign that they see a future in using patients DNA sequences when diagnosing patients.

On the cusp (still) We've been on the verge of pushing genomics into diagnostics for years. Illumina added a new division for diagnostics back in 2008. Four years later, we're further along, but we're still a ways away from where DNA sequencing is a mainstream test done by most doctors.

The limiting factor is a combination of usefulness and cost, both of which are headed in the right direction. We're learning more about how genetic variations affect patients' physiologies. And the discoveries are accelerated as more people get their genomes sequenced.

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The Future of DNA Sequencing Isn't in the Lab

Posted in DNA

DNA will play pivotal role in Ridgeway case

DENVER - DNA evidence will almost certainly play a pivotal role in the ongoing investigation into the murder of Jessica Ridgeway, but a noted DNA expert cautions it can also potentially lead investigators down a rabbit hole.

Take the backpack that was found shortly after Jessica Ridgeway was reported missing as an example. It was found in a neighborhood in Superior.

"What if some kid sneezed on [Jessica's] backpack during recess [at her school]? Then we're focusing all of our efforts on this, and when we don't find that person we then think we haven't found the killer," Dr. Elizabeth Johnson told 9News from her California home on Monday.

Dr. Johnson has more than 20 years of experience working in the field of DNA technology. She was called by the defense to testify during the Kobe Bryant case in Colorado. She currently works in private forensic consultation.

"I think the biggest misconception about DNA technology is that it is infallible and that there are never mistakes made," she said. "Just because you someone's DNA on an object doesn't make them guilty of a criminal act."

Of course, she said, the presence of particular bodily fluids can also be indicative of a criminal act, and thus lead investigators closer to a killer. But she cautions that CSI-like television shows have raised the expectations of many people in inappropriate ways.

Dr. Andrew Bonham is a professor at Metropolitan State University and says he still believes DNA will help in the Ridgeway murder investigation.

"I am almost 100 percent convinced," the molecular biology expert said. "That (the killer) is going to leave traces of DNA behind and that investigators are going to find those traces."

He said that current technology allows investigators to collect even seemingly miniscule portions of bodily fluids in an effort to identify critical DNA markers.

"We're now talking about almost less than you can perceive," he said.

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Posted in DNA

BVU students present research on environmental impact of Bt corn

Jennifer Heim and John Killpack. /Photo submitted

The students were invited to share their findings at the North Central Chapter (NCC) Conference of the International Society of Wetland Scientists (SWS) in Chesterton, Ind., in late September. Jennifer also earned a competitive travel grant to attend the conference and present their project, entitled, "Impact of Bt Corn Leaf Detritus on Aquatic Macroinvertebrates."

Jennifer developed the proposal for the project during the spring semester of her sophomore year. She chose the topic because she recognized its significance to agriculture and the health of freshwater systems.

"I've always been curious about anthropogenic effects on ecosystems, and when told to select a topic that I would be working on for three years, I knew I wanted to find something interesting that was currently impacting the environment and humans," says Jennifer. "I browsed current science journal articles and happened across one about the impact of Bt corn detritus on macroinvertebrate communities. I had heard of Bt corn before seeing that article, but didn't know much about it. After I read the article, I realized that this was something that could have serious impacts on freshwater systems near agricultural land."

Bt corn has been genetically altered to express the bacterial Bt toxin, which is poisonous to insect pests. In biology, detritus is non-living particulate organic material which can include the bodies or fragments of dead organisms. Aquatic macroinvertebrates are found in lakes, streams, ponds, marshes and puddles and help maintain the health of the water ecosystem by breaking down leaf detritus and other organic matter to perpetuate the cycling of nutrients and energy through the system.

John grew up on a farm and was relatively familiar with Bt corn and its effects on the environment. He had also previously completed an internship with the Missouri River Basin that gave him greater knowledge about macroinvertebrates and water quality. He was intrigued enough to get involved with Jennifer's project.

"When I heard that Jennifer was basing her project in these areas, I decided to join her and assist in the research project," John says. "Our hypothesis was that the presence of Bt corn leaves as a food source for aquatic macroinvertebrates will show negative environmental effects in lab and field testing when compared to non-Bt corn leaves. In our research, we found negative survivability effects on tricopteran macroinvertebrates when comparing results from Bt corn leaves verses non-Bt-corn leaves."

The research project allowed John to obtain experience in a field-based project in order to assist in his decision to pursue ecological research or a human health direction after he graduates from BVU in the spring.

Beyond the results of the research, Jennifer also learned about enduring the challenges and trials of her project.

"One of the most important things I've learned is patience and acceptance that not everything is going to work out the way you want it to on your first try," Jennifer says. "This was research, not a controlled lab exercise. With that, you're going to have to go through a lot of trial and error for things to work, and even then you cannot always expect to get the results you want to see."

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BVU students present research on environmental impact of Bt corn

Einstein establishes the Paul F. Glenn Center for the Biology of Human Aging Research

Public release date: 15-Oct-2012 [ | E-mail | Share ]

Contact: Kim Newman sciencenews@einstein.yu.edu 718-430-3101 Albert Einstein College of Medicine

October 15, 2012 (BRONX, NY) Albert Einstein College of Medicine of Yeshiva University has received a $3 million grant from the Glenn Foundation for Medical Research to establish the Paul F. Glenn Center for the Biology of Human Aging Research. The grant will fund research to translate recent laboratory and animal discoveries into therapies to slow human aging.

Aging contributes to many of the debilitating and costly diseases including cancer, cardiovascular disease and diabetes that burden the United States and many other countries. This complex but universal condition causes individual cells and the body as a whole to decline in function. Finding the mechanisms that underlie the aging process may lead to treatments that slow aging, prevent or limit common diseases, and allow people to live healthier, longer lives.

"Unless we find protective mechanisms to delay aging, we will not make progress against age-related diseases," said Nir Barzilai, M.D., co-director of the new center as well as director of the Institute for Aging Research, the Ingeborg and Ira Leon Rennert Chair in Aging Research, and professor of medicine and of genetics at Einstein. "With this valuable grant from the Paul F. Glenn Foundation, we hope to make significant advances toward understanding the aging process and improving human health."

"The generosity of Paul F. Glenn and his foundation is a welcome shot in the arm for aging research in the United States, which is chronically underfunded," said Jan Vijg, Ph.D., co-director of the new center, the Lola and Saul Kramer Chair in Molecular Genetics, and professor and chair of genetics and professor of ophthalmology and visual sciences at Einstein. "This grant will help Einstein to maintain its position as one of the world's leaders in this rapidly growing field."

"Paul F. Glenn has been a visionary in aging research for more than 30 years," said Ana Maria Cuervo, M.D., Ph.D., co-director of the new center, the Robert and Rene Belfer Chair for the Study of Neurodegenerative Diseases, and professor of developmental and molecular biology, of anatomy and structural biology and of medicine at Einstein. "Some of us got to know him when we were still graduate students and he came to scientific conferences to see the data as it was being developed. Paul's personal approach to science has made a big difference to many of us in the field of aging research and has contributed to the career development of many young investigators."

The funding, in the form of pilot and feasibility study grants, is targeted to several specific research projects: uncovering the genetic and epigenetic mechanisms that protect humans against aging and age-related diseases, testing the effectiveness of the first-generation pro-longevity therapies, and developing novel preventive and therapeutic interventions against cellular aging in humans.

###

Drs. Barzilai and Cuervo are also co-directors of Einstein's Institute for Aging Research and, together with Dr. Vijg, of the Nathan Shock Center for the Basic Biology of Aging. Both centers are funded by the National Aging Institute, part of the National Institutes for Health.

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Einstein establishes the Paul F. Glenn Center for the Biology of Human Aging Research

Obama, Romney have ways to make you vote

(Crown Publishing Group) - The Victory Lab by Sasha Issenberg.

More from PostPolitics

Chris Cillizza

THE FIX | Its ridiculous that the two campaigns dont want Crowley to ask followup questions.

Felicia Sonmez

Campaign ramrodded their way into kitchen so Ryan could get picture taken washing dishes, charity chief says.

Chris Cillizza

How did the late-night comedy show see the vice presidential debate?

Turnout is where precision targeting really works, says Sasha Issenberg, author of The Victory Lab: The Secret Science of Winning Campaigns. Political scientists are using the tools of behavioral economics and behavioral psychology to understand why people vote and how to enforce that habit; campaigns are building voting scores for people in their databases like the financial industry builds credit scores.

Does it work? More than 1.1 million people already have voted, according to early voting statistics collated by George Mason University political scientist Michael McDonald, and plenty of them were prodded to do so without ever knowing it.

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Obama, Romney have ways to make you vote

Jacqueline Laurita of 'Real Housewives of New Jersey' Shares 'Ultherapy' Beauty Secret

ABC News' Juju Chang and Cathy Becker report:

Jacqueline Laurita lives a life in the spotlight.

As a star of the hit reality-TV show " The Real Housewives of New Jersey," the mother of three has been engaged in an on-air fight with former friend Teresa Guidice, a fight that most recently played out on the show's three-part reunion.

"It would just take a lot at this point," Laurita, 42, told "Good Morning America" of a possible reconciliation with her co-star and one-time friend. "It's hard. It's stressful."

Another thing Laurita can't reconcile is the concept of aging gracefully.

"I think that when people age gracefully, the people that age gracefully, it's because they can. Just for me, if I can fight it, I will," she said.

To deal, in part, with the reality of appearing on reality TV, Laurita admitted that she has tried many beauty approaches and treatments, including Botox, fillers and Fraxel laser.

The newest weapon in Laurita's fight is called "Ultherapy," a noninvasive skin treatment that uses ultrasound to lift, tone and tighten loose skin.

RELATED: Can you stop the clock with preventive Botox, thermage treatments?

Dr. William Song, an aesthetic medicine specialist at Omni Aesthetics in Oakland, N.J., performs the procedure for Laurita. He told "GMA" that the procedure was one of his favorite anti-aging therapies. And there's zero downtime.

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Jacqueline Laurita of 'Real Housewives of New Jersey' Shares 'Ultherapy' Beauty Secret

Why Emily Owens, M.D. Is Grey's Anatomy 2.0

Mamie Gummer, Ellen Pompeo

From the moment Emily Owens, M.D. begins, one thought will surely cross your mind: This feels very familiar.

That's because The CW's new medical dramedy is pretty similar to ABC's stalwart Grey's Anatomy from the titular protagonists' names to the voiceovers and even the characters, the tone of Shonda Rhimes' medical drama is present.

Emily Owens stars Mamie Gummer (The Good Wife, Off the Map) as a first-year intern who, while working alongside her best friend/crush (Justin Hartley) and her childhood nemesis (Aja Naomi King), must learn the hard way that hospitals are a lot like high school.

VIDEO: Watch the premiere of The CW's Emily Owens, M.D. online now!

"I think that every medical show now is going to be compared to Grey's," Gummer tells TVGuide.com. "I did a show called Off the Map and it was set in a jungle and everyone was comparing it to Grey's. It's sort of inevitable. Grey's has gotten a little gray. It has more somber notes generally than we do, but Grey's is a great show and it's been running forever, so obviously they're doing something right."

What they're doing right is exactly what Emily creator Jennie Snyder Urman probably hopes to capitalize on considering archetypes from the Shondaland flasgship series can be found in the CW show. Let's take a look at the characters to see how similar they really are:

Emily Owens (Mamie Gummer) is Meredith Grey: Both docs came to their respective hospitals wide-eyed and hoping to make a difference, but where Mer went dark and twisty, Emily is still hoping to hang on to her bright and shiny side, which offers a lot of awkward comedy as she navigates the waters of residency. "She's generally awkward," Gummer says. "She's lacking in social graces, but she's very well-intentioned. She's smarter and has more depth than she's given credit for or that she's aware of. She's a kind of geeky character." And although both characters use voiceover narration, expect more from Emily than what you're used to from Grey's.

Will Rider (Justin Hartley) is Derek Shepherd: Like Derek was to Meredith, this is ultimately the heartthrob that you and Emily will be rooting for her to end up with. No random one-night stands here, though, as the duo went to medical school together and she's been harboring a longtime crush on her pal. "You learn that they have a real friendship founded on a lot of shared experience and true affection," Gummer says. "It's not just a girlish crush that she has." And just like Grey's dragged out the will-they-won't-they tension for MerDer, so too will Emily as Gummer says they're still working through that in episodes they're currently filming.

Vote for your favorite new TV shows in our Fall Popularity Contest!

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Why Emily Owens, M.D. Is Grey's Anatomy 2.0

Young Travel Manager Winner of the KDS iPad

(PRWEB UK) 15 October 2012

In July 2012, KDS launched a competition asking participants to share a business travel story or anecdote via the KDS Facebook page. Stories told ranged from travel date confusion to having passengers stuck in a corridor whilst exiting their plane and KDS would like to thanks all those participants that have told their funny stories all of which illustrate the unexpected things that can happen during a business trip.

Soon to graduate from the ESCAET, Marie is involved with the Around the world in 80 hours program developed by ACTE, and already the programs participants have discovered travel and expense management in Beijing, Sydney and Delhi. Having worked as a travel buyer in several companies, this training allows me to gain additional knowledge of travel management, says Marie Cobac. Whats more, this program is a good way to understand business travelers themselves, their expectations and possibly to help find the balance between the travellers needs and the savings expected by the company.

Mobile Technologies are part of todays business travel and travel management professionals have to adjust their strategies accordingly. KDS offers a mobile version of its travel and expense tool, with the KDS Mobile application. Due to the increasing use of digital tablets by business travellers, this tool has become indispensable. During KDS Now 2013 (the annual travel and expense conference) KDS will launch officially the tablet app introduced last year: Neo, a door-to-door booking tool in a few clicks and in one minute.

The iPad has already been established as the next mobile device of choice by todays modern business traveller and so we are happy to offer this prize to this young travel manager, says Stanislas Berteloot, Marketing Director at KDS.

If you would like more information about the Around the World in 80 Hours program, please visit the ACTE website or contact Amber Kelleher, Manager Global Education(akelleher(at)acte(dot)org) at the Association of Corporate Travel Executives (ACTE).

About KDS KDS (http://www.kds.com) is a leading international provider of Travel & Expense (T&E) management systems for private and public sector organisations. The KDS unified Software-as-a-Service (SaaS)-based technology addresses the full range of T&E requirements, from travel policy definition and enforcement, and the online self-booking of travel, through to automated travel expense processing and invoice reconciliation. With each stage handled seamlessly by the KDS fully-integrated technology, clients achieve significant efficiencies and cost-savings. KDS offers the most extensive back-end connectivity to financial service and travel providers (airline, car, rail and hotel) in the industry, ensuring optimised pricing and up-to-the-minute inventory control.

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Young Travel Manager Winner of the KDS iPad

Picture Our World travel photo contest

In three months, more than 5,000 pictures poured in for our first Picture Our World travel photo contest this summer. It seemed pretty obvious: We couldn't stop at just one.

So, Picture Our World is back and even bigger for its second go-round.

This time, the photo contest will run for an entire year. We will have three categories California, national and international with first- and second-place winners in each.

Our marketing department has arranged big prizes: a five-night trip to Palau for the grand prize; Monterey getaways for first place; and $200 gift certificates to Camera West for second place. Click here for full prize details.

We also will publish the winning photos in the Travel section on Nov. 11.

Here's how the contest works:

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Picture Our World travel photo contest

All about the Sanganai/Hlanganani: World Travel and Tourism Africa Fair

Background SANGANAI/Hlanganani World Travel and Tourism Africa Fair is an annual Tourism trade fair organised by the Zimbabwe Tourism Authority (ZTA). It showcases the widest variety of Africas best tourism products, and attracts international visitors and media from across the world.

The fair is the successor of Shanyai/Vakatshani, the Zimbabwe International Travel Expo (Zite) that was held annually at the Harare International Conference Centre.

Zite started as a small expo in 1982 and grew over the years to become one of Africas leading tourism showcases by 2007. The past four editions of Sanganai/ Hlanganani were a resounding success and attracted the leading African destinations and major world tourism markets such as South Africa, Botswana, Malaysia, China, Zambia, Malawi, Kenya, Indonesia, Italy and many others.

The editions have seen the whole world converging in Zimbabwe in the form of high calibre international buyers as well as exhibitors, hence achieving its main purpose of bringing the world to Africa, where the world meets Africa. The 2012 edition will be held in the Capital city, Harare, under the the theme, Celebrating Africas Tourism Diversity and is expected to ride on the successes gained by the previous editions and is therefore an opportunity not to be missed.

The fair will target among other exhibitors the following:

Dates and times: Sanganai/Hlanganani World Travel and Tourism Africa Fair will run for four days starting on October 18 and ending on October 21 2012. October 18 and 19 are trade days October 20 and 21 are trade and public days Opening times are: 9am 5pm The fair will be filled with a lot of business and networking opportunities during exhibition hours and a lively social and cultural programme parallel to the exhibition and after hours, providing more opportunities to network. The host country Zimbabwe a world of wonders. Zimbabwe is a plural society where people of different races live in harmony. Zimbabweans living in urban areas have a westernised lifestyle, while in the country areas many African traditions have been preserved. The host city Harare The Sunshine and Jacaranda City. The Sunshine and Jacaranda City is the countrys capital, commercial and industrial centre. It is a modern but not so sophisticated city, characterised by flowering trees, colourful parks and contemporary architecture. Harare has direct air access from major regional airports.

It is only an hour and a half flight from Johannesburg and an hour from the majestic Victoria Falls. There are a number of airlines flying into Zimbabwe.

Harare as a tourist destination possesses so many wonderful tourist places, wonderful and friendly people leaving a warm welcoming effect on all those travelling to this city. Major highlights are the National Heroes Acre, Mbare Msika, The Balancing Rocks, Lake Chivero and the National Art Gallery. The venue Harare International Conference Centre. The Rainbow Towers Harares Luxury Hotel and Harare International Conference Centre is a complex that was built 25 years ago and it was formerly known as the Sheraton Harare Hotel and International Conference Centre. The complex hotel is now owned by one of Zimbabwes leading hotel groups, the Rainbow Tourism Group (RTG). Pride of the RTG

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All about the Sanganai/Hlanganani: World Travel and Tourism Africa Fair

Raspberry Pi: The Small Computer With The Big Ambition (To Get Kids Coding Again)

If youre a hardware hacker who knows your apples youll have heard of the Raspberry Pi and maybe even bought one already. Its the super cheap mini-computer which featured prominently at ourHackathon event last month.

But theres more to the Pi than a decent processor at bargain basement prices ($35/a $25 version is coming soon). We got the chance to chat to Eben Upton, founder and trustee of the not-for-profit Raspberry Pi Foundation and the man responsible for the overall software and hardware architecture of the Pi about the very big-hearted ambition behind the project.

TC: What was your motivation in creating Raspberry Pi what were you setting out to try and achieve?

Eben: I was working at the university in Cambridge about six years ago and I had this awful experience of seeing the number of people applying for Computer Science every year going down and the sorts of things theyd have to do getting less and less impressive.Ever since then theres been an effort largely focused around the computer centre in Cambridge to develop some sort of system, some sort of platform for giving kids the opportunity to get involved in programming.

And this went through a number of iterations, and during that process I joined Broadcom as a chip architect, and fortunately it turns out that theres a Broadcom chip that I was involved in designing which has pretty much exactly all the features you need for a low cost programming platform for kids. And thats where the whole thing came from.First this realisation we had a problem and then some sort of slightly contrived good luck in having access to a platform that we could use to make this.

Weve always had this idea that youre not going to appeal to children with a platform that cant do anything interesting, that cant do anything recognisably modern. So one of the nice things about Raspberry Pi is weve ended up with a platform that can play 1080p can play Blueray quality video; thats got more graphical power than a Nintendo Wii; its something which is recognisable its not a retro machine. It may look a little retro but in terms of performance its a recognisably modern piece of hardware.

TC: Did you attribute the decline in programming skills to a lack of hack-friendly devices?

Eben: I grew up with a computer I could program. I learnt to program not because anyone ever thought of teaching me to program and I think a lot of people of the same generation had the same experience an experience that is transparently not available to children now.

Not every child has a PC, even the ones who do have a PC, the PC is not a particularly friendly environment for those who want to program. So our hypothesis is this is whats happened: we started to lose those programmable 8-bit machines of the late 80s that then led in quick succession to the loss first of kids who were programming, then it was undergraduates who were programing, and then of graduate recruits to industry who were programming.

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Raspberry Pi: The Small Computer With The Big Ambition (To Get Kids Coding Again)

'Sky kings' and a skydiver cap day of wonder

(The brief video shows an F-22 Raptor flying formation with a vintage P-51 Mustang.)

The Miramar Air Show celebrated a half century of manned space flight over the weekend, a tip of the cap to former Marine fighter pilot John Glenn, who went on to become the first American to orbit Earth. The tribute turned out to be more timely than anyone could have guessed. Midway through Sunday's show, an announcer told a crowd of 100,000 people that someone else was pushing the boundaries of flight. Austrian Felix Baumgartner had just jumped from a balloon traveling 24 miles above earth. He parachuted softly to the ground, landing in the wide open spaces of New Mexico.

The announcement came while a jet was crackling overhead at Miramar, which also was fitting; Sunday was the 65th anniversary of the day that test pilot Chuck Yeager became the first human to break the sound barrier in an aircraft. The achievement would lead to extraordinary advances in powered flight. Yeager's feat hasn't been forgotten. Volunteers at the San Diego Air & Space Museum are building a full-size replica of the Bell X-1 that Yeager rode into history. It will go on display in December.

Sunday's wrap-up of the three-day Miramar Air Show highlighted such bravado. But the focus, as always, was on demonstrating Navy, Marine and Air Force aerial firepower. The spectators who snaked through the base's gates in long lines of traffic got to see everything from a vintage P-51 long-range fighter-bomber to the MV-22 Osprey to blindingly fast F-22 Raptor and FA-18 Super Hornet. Soldiers, sailors and Marines also dropped from the sky as the military showed off its skilled at precision parachuting. The reaction could be seen in the reaction of a little boy who stood with his father on the flight line. He looked up, stuck his fingers in his ears to block the shriek of jets, and smiled.

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'Sky kings' and a skydiver cap day of wonder

Miramar Air Show ready to fly out of town

SAN DIEGO ---- The 57th annual Miramar Air Show, this year featuring the U.S. Navy's Blue Angels flying squadron and a tribute to space flight, will finish up a three-day run today at Miramar Marine Corps Air Station.

More than 700,000 airshow fans turn out each year for the free event, which opened Oct. 12 and concludes with an all-day show from 9 a.m. to 4 p.m. today.

This year's air show celebrates Miramar's occupants with the theme "Marines in Flight: Celebrating 50 Years of Space Exploration." Special static exhibits will honor the U.S. Marine aviators who made history in space, including retired senator and astronaut John Glenn and current NASA Administrator Charles Bolden.

Highlighting today's show will be the U.S. Navy's Flight Demonstration Squadron, better known as the Blue Angels. Their F/A-18 Hornets will close the show around 3 p.m.

Other military acts scheduled to perform are the Navy's F/A-18 Super Hornet, an F-22 Raptor stealth plane, an AV-8B Harrier (capable of vertical liftoff), the Marine Air-Ground Task Force demonstration team, the U.S. Army's Golden Knights parachute team and the Navy's Leap Frogs jump team. There will also be legacy flight formations, showing state-of-the-art aircraft flying together with vintage fighter aircraft.

Civilian performers include the Patriots Jet Team, a flying tribute to Bob Hoover, Sean Tucker's "Oracle Challenger," John Collver's AT-6 Wardog, Bret Willat's Sailplane, hang glider Dan Buchanan, stunt pilot Gregory Colyer, Hawker Beechcraft's Texan II Demo plane and Smoke-n-Thunder, a car that races down the tarmac spouting 20-foot flames from its afterburners. There will also be a Red Bull helicopter, the Silver Wings wingwalking team, a radio-controlled plane demonstration and many more.

On the ground, patrons are invited to tour more than 100 aircraft, military vehicles, weapons and hardware systems on display at the airfield. There will also be a consumer fair, simulator rides, a military recruiters' fair and food, beverages and gifts for sale.

Because of heightened security, on-base visitors should come prepared. Food and nonalcoholic beverages (no glass bottles) are allowed in, but large coolers, backpacks and large bags must stay in the car. All bags will be searched. No pets, bikes, skateboards, skates or scooters are allowed.

All three gates will be open for air show visitors. Drivers can enter through the North and West gates on Miramar Road, or through the East/Main gate off Interstate 15 or Kearny Villa Road. The South Gate, off Harris Plant Road, is for preferred parking only. Parking is prohibited along the Interstate 15 corridor, and violators will be ticketed.

Gates open to the public at 8 a.m. Visitors are advised to bring blankets, beach chairs and shade umbrellas. Preferred and bleacher seating is available for an additional charge.

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Miramar Air Show ready to fly out of town

Space flight leaders gather in Las Cruces for symposium

LAS CRUCES Less than 10 years ago, all the talk about the commercial space flight industry was conceptual. Today, it's about the five Ws who, what, where, when and why.

New Mexico has been a major player in the growth of the industry. It is preparing to start operations of Spaceport America, which is supposed to signal the start of everyday people having opportunities to fly commercially into space. Commercial space flight has already started, with cargo and payloads delivered to the International Space Station this summer.

To keep the synergy going, commercial space flight leaders will gather in Las Cruces this week for the International Symposium for Personal and Commercial Spaceflight. The symposium will be a two-day affair, Wednesday and Thursday at the New Mexico Farm and Ranch Heritage Museum, 4100 Dripping Springs Road, but other events associated with the symposium will also be conducted Tuesday and Friday.

"The personal and commercial space flight industry has come a long way since those early days," said Pat Hynes, symposium chairwoman, and director of the New Mexico Space Grant Consortium. "We have again brought together some of the most pre-eminent people in the world who are part of this exciting industry to share their knowledge, insights and visions."

A veritable who's who of personal and commercial space flight industry will be involved in this year's symposium. There will be 40 speakers at the conference, including Lori Garver,

Gov. Susana Martinez, and White Sands Missile Range commander Brig. Gen. Gwen Bingham will also be keynote speakers during the symposium. Bingham's speech, scheduled for 10:30 a.m. Wednesday, will be her first public appearance in Las Cruces since taking command at WSMR last month.

Martinez's speech will be at 9:30 a.m. Thursday.

"The list of people who will be speaking is impressive," Hynes said. "In this day and time, when the economy has prompted so many to curtail travel and appearances at conferences or symposiums, their willingness to come and participate says a lot about how much, and how well, this industry is progressing. The marketplace has been evolving, things have changed enormously."

Las Crucens Raja Taylor has attended several past symposiums, and said every speech and panel discussion is interesting.

"There's no way you could come from a symposium and not learned something," Taylor said. "Because so much of this has only been conceptual until now, it's fascinating to realize how far we've come in such a short period of time and where all of this new technology is going."

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Space flight leaders gather in Las Cruces for symposium

Korean Grand Prix, Yeongam – Race results

Sebastian Vettel heads Red Bull 1-2 in the Korean Grand Prix, with erstwhile points leader Fernando Alonso completing the podium.

11. Sergio Perez Mexico Sauber-Ferrari +1m 20.0s 12. Paul di Resta Britain Force India-Mercedes +1m 24.4s 13. Michael Schumacher Germany Mercedes-Mercedes +1m 29.2s 14. Pastor Maldonado Venezuela Williams-Renault +1m 34.9s 15. Bruno Senna Brazil Williams-Renault +1m 36.9s 16. Vitaly Petrov Russia Caterham-Renault +1 lap 17. Heikki Kovalainen Finland Caterham-Renault +1 lap 18. Timo Glock Germany Marussia -Cosworth +1 lap 19. Charles Pic France Marussia -Cosworth +2 laps 20. Narain Karthikeyan India HRT-Cosworth +2 laps

Rtd Pedro de la Rosa Spain HRT-Cosworth 16 laps completed Rtd Kamui Kobayashi Japan Sauber-Ferrari 16 laps completed Rtd Nico Rosberg Germany Mercedes-Mercedes 0 laps completed Rtd Jenson Button Britain McLaren-Mercedes 0 laps completed

Fastest lap:

Mark Webber Australia Red Bull-Renault 1m 42.037s lap 54

all results unofficial

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Korean Grand Prix, Yeongam - Race results