Stem cells are unquestionably some of the most amazing cells in the human body. These are undifferentiated cells that do not have a direct blueprint or specific destiny. They can become differentiated into specialized cells anywhere throughout the body. They are classified as 2 different types of cells, those that are from embryonic origin and those called adult stem cells.

In the developing embryo, these cells differentiate into ectoderm, endoderm, and mesoderm. These give us rise to our spine, nerves, and all our organs. Adult stem cells are primarily used to repair, replenish, and regenerate tissues.

Historically, stem cells can come from a variety of tissues. These include umbilical cord, fetal tissue, adipose, or the best source bone marrow.

Bone marrow stem cells have the highest numbers of cells when collected and tested compared to all others. This is by far the preferred method of stem cell therapy because of sheer numbers and the fact that they are coming from your own body. This is called autologous therapy.

Stem cell research worldwide goes back over 100 years, the German research is documented back to 1860. There are a wide range of studies and articles describing its dramatic benefit for chronic diseases. Many of these publications are available for you to read on my website.

In performing stem cell therapy, extremely strict guidelines must be followed in coordination with a specialized protocol. This ensures accuracy, sterility, and quality control of the procedure. This information gathered from the procedure, including various forms of documentation can be used for medical publication at a later date. Physician notes and procedure as well as a questionnaire filled out by patients periodically are part of this process. This enables the highest level of procedure and documentation possible.

Initially, patients are examined, appropriate blood or other testing is done and reviewed and schedule is made to begin procedure. Typically, stem cell therapy is done within 2 weeks of initial consultation.

On the day of procedure, stem cells are extracted from Bone Marrow, this takes 5-10 minutes then patients sit and relax while the processing is done. It is then washed and centrifuged 3 times to allow separation of cells and harvest stem cells. At the end of the procedure, microscopic analysis can estimate the number of stem cells available for injection. Injection can be done either into joint, connective tissue, muscle or for all other organs or systemic diseases, intravenously. Intranasal technique also used for MS, Parkinsons, and Alzheimers disease. Intravenous and nebulizer is used for COPD, Emphysema, and Pumonary Fibrosis.

Research shows the therapy may benefit the following:

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered mainstream. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

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Stem Cell Therapy - Dr. Christopher Calapai D.O.

The process begins first with a physical exam and in depth patient history. We do this to give you the best proper diagnosis and treatment. If additional information is needed, we will conduct the necessary imaging or laboratory reports. We will then discuss patient desires and expected outcomes as well as educate on his/her condition and all possible treatment options.

The Stem Cell procedure is minimally invasive, gathering a sample of adipose tissue from the abdomen. Theses cells remain sterile and after adult stem cells are extracted, they will be readministered back into the patient. This is done by one of the three methods: Intravenous, Intranasal or Localized.

Our Autologous Adipose Stem Cell producer is safe and there are no instances of cell rejection or disease transmission because the adipose extracted always remains in a sterile environment. In addition, all aspects of the procedure are performed in house and under a licensed physician.

Click on our Services page to learn more about the different types of therapy and treatments offered.

View the video below to learn more:

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NSI Stem Cell | Stem Cell Therapy Injection Treatment

FEATURED IN THE NEWS ACROSS THE NATION. THE WORLD RENOWNED PIONEER DR. DENNIS M. LOX, AN EXPERT IN SPORTS & REGENERATIVE MEDICINE TREATS PATIENTS FROM AROUND THE WORLD.

UPDATE: 09/20/2016Since Natasha Merangoli Stem Cell Treatment on her Ankle, she isgraduating from High School and now has a College Soccer Scholarship.

Derrick Dewan Brooks is an American former football linebacker who played in the National Football League for fourteen seasons. Twice recognized as a consensus All-American.He alsochose Dr. Lox for Stem Cell Treatment.

Ronnie Dean Coleman treated with Stem Cells by Dr. Lox is a retired American professional bodybuilder and the winner of the Mr. Olympia bodybuilding title 8 years in a row and is regarded as the greatest bodybuilders.

Dennis M. Lox, M.D. has applied his personal interest in sports medicine. As a World Renowned Stem Cell Pioneer. Dr. Lox helps elite athletes improve their functional level so they may return to sports.

Many patients are turning to stem cell therapy as a means of nonsurgical joint pain relief when their mobility and quality of life are severely affected by conditions like osteoarthritis, torn tendons, and injured ligaments. Dennis M. Lox, M.D. specializes in this progressive, innovative treatment that may be able to help you return to an active, fulfilling life.

Each week, Dr. Dennis Lox receives inquiries from aroundthe worldregarding stem cell therapy.

TRAVEL ARRANGEMENTS CAN BE MADE FOR YOU LOCAL OR INTERNATIONAL

Visit our Press Room

Stem cell therapy for joint injuries and osteoarthritis is suited for many individuals, fromprofessional athletes to active seniors. Adult mesenchymal stem cells, not embryonic stem cells, are used in this procedure, which is performed right in the comfort of Dr. Loxs state-of-the-art clinic. The cells are simply extracted from the patients own body (typically from bone marrow or adipose/ fat tissue), processed in our office, and injected directly into the site of injury. Conditions that can be addressed with stem cell treatment include osteoarthritis, degenerative disc disease, knee joint issues (such as meniscus tears), shoulder damage (such as rotator cuff injuries), hip problems (such as labral tears), and tendonitis, among others. For many patients, a stem cell procedure in the knee, hip, shoulder, or another area of the body relieves pain, increases mobility, and may be able to delay or eliminate the need for more aggressive treatments like joint replacement surgery.

If you have questions about adult stem cell therapy for joint injuries and arthritis, how the procedure is performed, and how the stem cells work to repair injured joints and tissues, Dr. Lox would be happy to educate you about the entire process.

Dr. Lox | Dr Dennis Lox

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Dennis M. Lox, M.D., Florida Tampa Stem Cell Therapy | PRP ...

COPD

Over 32 million Americans suffer from chronic obstructive pulmonary disease (also known as COPD). COPD is a progressive lung disease, however regenerative medicine, such as lung regeneration therapies using stem cells are showing potential for COPD by encouraging tissue repair and reducing inflammation to the diseased lung tissue.

Following up with stem cell therapy and exome therapy immediately in the first 36 to 48 hours after stroke symptoms surface has proven to be crucial to long-term recovery and regaining mobility again. Cell therapy also calms post-stroke inflammation in the body, and reduces risk of serious infections.

Parkinsons is a neurodegenerative brain disorder caused by the gradual loss of dopamine-producing cells in the brain. It afflicts more than 1 million people in the U.S., and currently, there is no known cure. Stem cell therapies have been showing incredible progress. Using induced pluripotent stem (iPS) cells, a mature cell can be reprogrammed into an embryonic-like, healthy and highly-functioning state, which has the potential to become a dopamine-producing cell in the brain.

A thick, full head of hair is possible, naturally! Stem cell and exosome therapy promotes healing from within to naturally stimulate hair follicles, which encourages new hair growth. Using your own stem cells, Platelet Rich Plasma (PRP) and exosomes, you can regrow your own healthy, thick hair naturally and restore your confidence!

Erectile Dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual intercourse. Regenerative medicine offers a non-surgical option that commonly uses the patients own stem cells, exosomes, and other sources of growth factors to regenerate healthy tissue to improve performance and sensation.

If chronic joint pain is derailing your active lifestyle, then youre not alone. Regenerative medicine offers a non-surgical option that commonly uses the patients own stem cells, exosomes, and other sources of growth factors to reduce inflammation, promote natural healing and regenerate healthy tissue surrounding the joint for relief.

Multiple Sclerosis (MS) affects 400,000 people in the U.S., and occurs when the body has an abnormal immune system response and attacks the central nervous system. Regenerative medicine now offers treatment for MS with stem cell therapy, which is an exciting and rapidly developing field of therapy. Stem cells work to repair damaged cells these new cells can become replacement cells to restore normal functionality.

Spinal cord injuries are as complex as they are devastating. Today, cellular treatments, usually a combination of therapies, such as stem cell, Platelet Rich Plasma (PRP) and exosome therapy with growth factors are showing promise in contributing to spinal cord repair and reducing inflammation at the site of injury.

If you have chronic nerve injury pain that doesnt fade, your health care provider may recommend surgery to reverse the damage. However, regenerative medicine offers a non-surgical option to repair damaged tissue and reduce inflammation at the site of injury. Stem cell therapy commonly uses the patients own stem cells, exosomes, and other sources of growth factors to regenerate healthy tissue.

Neuropathy also called peripheral neuropathy occurs when nerves are damaged and cant send messages from the brain and spinal cord to the muscles, skin and other parts of the body. Simply put, the two areas stop communicating. Stem cell and exosome therapies treat damaged nerves affected by neuropathy, and they have the ability to replicate and create new, healthy cells, while repairing damaged tissue.

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Stem Cell Center Of NJ - New Jersey Stem Cell Therapy

At Northwest Pain Relief Center, non-invasive medical procedures are the mainstay of our practice. Using the most up-to-date techniques, our staff treats patients as whole people. We provide a comprehensive diagnostic assessment in order to design a customized strategy for relief from medical concerns with patients in Washington and Alaska. Stem cell research has advanced to a point that, at Northwest Pain Relief Center, stem cell therapy is part of our array of treatments, designed to help our patients attain their wellness goals and achieve a higher quality of life.

Until recently, treatment options for people with osteoarthritis of the knee were limited. Steroid injections, joint replacement surgery, and physical therapy were often the only treatment options. Now, throughout Washington and Alaska, stem cell therapy injectionsfor knee osteoarthritis are available, at Northwest Pain Relief Center. Stem cell therapy also has applications for treating Achilles tendonitis, rotator cuff tendonitis, and degenerative arthritis.

Stem cell injections work with the bodys natural ability to heal itself. Unlike treatments that simply address the symptoms, stem cell therapy actually promotes repair of the body, restoring degenerated tissue. Stem cell therapy injections also contain hyaluronan, which eases pain and restores mobility by lubricating joints and tendons. This therapy fits well with Northwest Pain Relief Centers integrated approach to wellness, addressing the source of issues, rather than just treating the symptoms.

At Northwest Pain Relief Center, non-invasive medical procedures are the mainstay of our practice. Using the most up to date techniques, our staff treats patients as whole people, providing a comprehensive diagnostic assessment in order to design a customized strategy for relief from medical concerns in Washington and Alaska. Stem cell research, for example, has advanced to a point that, at Northwest Pain Relief Center, stem cell injections as part of our array of treatments, designed to help our patients attain their wellness goals and achieve a higher quality of life.

For instance, until recently, treatment options for people with osteoarthritis of the knee were limited. Steroid injections, joint replacement surgery, and physical therapy were often the only treatment options. Now, in Washington and Alaska, stem cell injections for knee osteoarthritis are available, at Northwest Pain Relief Center. Stem cell therapy also has applications for treating Achilles tendonitis, rotator cuff tendonitis, and degenerative arthritis.

We treat a range of conditions including spondylolisthesis, spinal arthritis, intervetebral disc degeneration, spinal stenosis and herniated discs. Even those with little or no cartilage around their knee have benefited from Regenerative Musculoskeletal Medicines procedures.

Regenerative Musculoskeletal Medicine offers a non-invasive alternative to surgery and steroid injections for this problem. We also treat the underlying issues that cause the pain using either Regenerative Musculoskeletal Medicines advanced form of Platelet rich plasma (PRP) therapy or stem cell therapy.

Quite a number of people suffering from ITB syndrome do not want to risk the side effects that come with steroid injections, while others do not want to resort to surgery. If you are in this category, you can visit Regenerative Musculoskeletal Medicine for a non-invasive alternative to treat ITB syndrome.

Those suffering from meniscus tear are increasingly becoming aware of the implications of removing the meniscus though surgical operation, they also prefer not to risk the side effects that come with steroid injections.

Our in-office, same-day procedures will alleviate your hip pain regardless of the cause. We treat a range of conditions including avascular necrosis, hip arthritis, sacroiliac joint dysfunction, labral tears, tendonitis and complications from a prior injury to the hip joint.

If you are suffering from labrum tear, you can visit us for a painless alternative to cortisone injections and/or surgery. After undergoing our procedure it will take you a very short time to recover. Regenerative Musculoskeletal Medicines procedure for labrum tears includes a combination of stem cell therapy and PRXP treatment.

Regenerative Musculoskeletal Medicine surgeons utilize your bodys own cells to rebuild and strengthen the damaged tissues. And with just as little as one visit you can be on the road to living a life free of pain.

Regenerative Musculoskeletal Medicine treatment for rotator cuff tears involve both Regenerative Musculoskeletal Medicines complex form of platelet rich plasma (PRP) therapy and stem cell therapy, which has been fortified and enhanced with cytokines and additional natural growth factors.

Our revolutionary platelet rich plasma (PRP) and stem cell procedures treat all the damages and underlying conditions that cause you pain. The surgeons use your bodys own bone marrow, fat and cells which reside in your blood to rebuild and strengthen the damaged tissue.

Many patients with tennis elbow run away from surgery and steroid injections. At Regenerative Musculoskeletal Medicine, we offer an effective, non-invasive alternative to steroid injections and surgery. Our procedures treat all the underlying damages that cause the elbow pain. We use stem cell therapy and our advanced form of PRP plus other regenerative procedures.

At Regenerative Musculoskeletal Medicine we offer these alternative procedures to ensure that your treatment is painless. We utilize mesenchymal stem cells which prepare the ability for the stem cells to their work and shematopoietic stem cells which are the drivers of tissue regeneration. This innovative treatment method has already been proven effective in clinical studies.

Distal biceps tendon tear typically occurs as a result of sudden injury and is not a result of other medical conditions. The tear can occur during heavy lifting without bending the elbows. In a situation where the elbow joints are forcefully straightened the distal tendon gets separated from the bicep.

If you have wrist pain that has been bothering you for some time, then you are at the right place. At Regenerative Musculoskeletal Medicine our healthcare providers offer same-day in-office procedures to alleviate your hand and wrist pain whether it results from wrist arthritis, carpel tunnel syndrome, tendonitis or hand arthritis.

Temporary carpal tunnel syndrome can be treated using the conservative treatments. But these treatments are sometimes not effective in relieving the pain. Such case may require PRP treatment and stem cell therapy which has been applied successfully.

With just one visit to our providers you can be on the road to living a pain free life. Our doctors utilize your bodys own cells, which reside in your blood, bone marrow, and fat, to rebuild and strengthen damaged tissue.

At Regenerative Northwest Pain Relief Centers we have introduced a new regenerative technique for the treatment of plantar fasciitis. We treat the stressed connective tissue with an injection of the patients own PRP and stem cells. Our procedure regenerates damaged tissue while reducing pain.

Call Northwest Pain Relief Center Today

If youre seeking stem cell therapyin either Washington or Alaska, Northwest Pain Relief Center can help, offering non-invasive physical medicine treatments, including stem cell injections and physical therapy, in both Washington and Alaska.For your FREE consultation, call us today at 866-592-0228

Or visit our Locations page to find our clinic nearest you!

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Stem Cell Therapy - Northwest Pain Relief Centers

Multiple sclerosis (or MS) is a degenerative disease involving the deterioration of nerve cells. MS attacks the central nervous system (CNS), which is made up of the brain, spinal cord, and optic nerves.

Autoimmune diseases are conditions in which the patients immune system generates cellular and antibody responses to substances and tissues normally present in the body.

In each condition there is chronic obstruction of the flow of air through the airways and out of the lungs, and the obstruction generally is permanent and may be progressive over time.

Rheumatoid Arthritis is an autoimmune disease that attacks the bodys own tissues, specifically the synovium, a thin membrane lining the joints. As a result, joint fluid builds up, causing pain in the joints and inflammation thats systemic.

Parkinson's disease is a chronic progressive neurological disease that affects nerve cells (neurons) in an area of the brain known as the substantia nigra.

Osteoarthritis, or degenerative joint disease, is the most common type of arthritis. It is caused by the degradation of a joints cartilage.

With the onset of Alzheimers disease, information transfer at the synapses (the connection between the nerve cells and extensions) starts to break down, and the number of synapses decreases significantly.

Diabetes is the condition in which the body does not properly process food for use as energy. When you have diabetes, your body either doesn't make enough insulin or can't use its own insulin as well as it should.

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StemGenex - Stem Cell Therapy, Stem Cell Treatments, Stem ...

Lung Institute | Stem Cell Treatment for COPD & Emphysema Treatment

Stem Cell Therapy Can Help.

At the Lung Institute, we recognize that all patients have their own stories. While they have chronic lung conditions in common, our patients have had all kinds of careers and hobbies. Whether they enjoy growing plants in the garden, playing a round of golf or creating delicious meals, our patients are unique and deserve treatments unique to them.

At the Lung Institute, we screen each patient thoroughly, focusing on medical history and current condition to encourage only the best-possible treatment results.

Using the natural maintenance capabilities of stem cells, we first withdraw and separate the patients stem cells from their blood or bone marrow. We then reintroduce the stem cells into the body where they come to rest inside the lungs, promoting both natural healing and inflammation reduction.

To learn more about how stem cells work, review our Stem Cell Treatment Basics and discover how stem cell therapy can work to affect your quality of life. Click on the links below to read more about the two treatments we offer.

* All treatments performed at Lung Institute utilize autologous stem cells, meaning those derived from a patient's own body. No fetal or embryonic stem cells are utilized in Lung Institute's procedures. Lung Institute aims to improve patients' quality of life and help them breathe easier through the use of autologous stem cell therapy. To learn more about how stem cells work for lung disease, click here.

All claims made regarding the efficacy of Lung Institute's treatments as they pertain to pulmonary conditions are based solely on anecdotal support collected by Lung Institute. Individual conditions, treatment and outcomes may vary and are not necessarily indicative of future results. Testimonial participation is voluntary. Lung Institute does not pay for or script patient testimonials.

Under current FDA guidelines and regulations 1271.10 and 1271.15, the Lung Institute complies with all necessary requirements for operation. The Lung Institute is firmly in accordance with the conditions set by the FDA for exemption status and conducts itself in full accordance with current guidelines. Any individual who accesses Lung Institute's website for information is encouraged to speak with his or her primary physician for treatment suggestions and conclusive evidence. All information on this site should be used for educational and informational use only.

As required by Texas state law, the Lung Institute Dallas Clinic has received Institutional Review Board (IRB) approval from MaGil IRB, now Chesapeake IRB, which is fully accredited by the Association for the Accreditation of Human Research Protection Program (AAHRPP), for research protocols and stem cell procedures. The Lung Institute has implemented these IRB approved standards at all of its clinics nationwide. Approval indicates that we follow rigorous standards for ethics, quality, and protections for human research.

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Lung Institute | Stem Cell Treatment for COPD & Emphysema

At Neuropathy & Pain Centers of Texas three convenient locations, including Fort Worth, non-invasive medical procedures are the mainstay of our practice. Using the most up to date techniques, our staff treats patients as whole people, providing a comprehensive diagnostic assessment in order to design a customized strategy for relief from medical concerns in the Dallas/Fort Worth area. The technology has advanced to a point that, at Neuropathy & Pain Centers of Texas, we apply stem cell treatments designed to help our patients attain their wellness goals and achieve a higher quality of life.

For instance, until recently, treatment options for people with osteoarthritis of the knee were limited. Steroid injections, joint replacement surgery, and physical therapy were often the only treatment options. Now, regenerative injections for knee osteoarthritis are available at Neuropathy & Pain Centers of Texas. Regenerative cellular therapy also has applications for treating Achilles tendonitis, rotator cuff tendonitis, and degenerative arthritis.

Stem cell research has made it so these injections work with the bodys natural ability to heal itself. Unlike treatments that simply address the symptoms, stem cell therapy actually promotes repair of the body, restoring degenerated tissue. Stem cell injections also contain hyaluronan, which eases pain and restores mobility by lubricating joints and tendons. This therapy fits well with Neuropathy & Pain Centers of Texass integrated approach to wellness, addressing the source of issues, rather than just treating the symptoms. To learn if youre a candidate for stem cell therapy, contact one of our locations, including Fort Worth to get more info and set up a free consultation with one of our specialists.

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Stem Cell Therapy | Neuropathy and Pain Centers of Texas

FEATURED IN THE NEWS ACROSS THE NATION. THE WORLD RENOWNED STEM CELL PIONEER DENNIS M. LOX, M.D. AN EXPERT IN SPORTS & REGENERATIVE MEDICINE TREATS PATIENTS FROM AROUND THE WORLD.

07/31/2017 at 10am with Ian Beckles former NFL Player.

Next Show will air 08/07/2017 at 10am with Soccer Player Natasha Merangoli and her successful recovery with Stem Cells.

Third show will air 8/14/2017 at 10am. Morning Blend Dr. Lox

Helping the body heal itself.

UPDATE: 09/20/2016 Since Natasha Merangoli Stem Cell Treatment on her Ankle, she isgraduating from High School and now has a College Soccer Scholarship.

Ronnie Dean Coleman treated with Stem Cells by Dr. Lox is a retired American professional bodybuilder and the winner of the Mr. Olympia bodybuilding title 8 years in a row and is regarded as the greatest bodybuilders.

Derrick Dewan Brooks is an American former football linebacker who played in the National Football League for fourteen seasons. Twice recognized as a consensus All-American.He alsochose Dr. Lox for Stem Cell Treatment.

Nick DeFrancesco

Nick DeFrancesco a 14 year old Wrestler from New Jersey suffered from Hip Avascular Necrosis and had to usecrutches for months due to his pain. His Orthopedic Physicians recommended a total hip replacement surgery, due to his pain and loss of activity level.

Nick decided to try Stem Cell Treatment instead with Dr. Lox and after two years wanted to show the world how well his Stem Cell Treatment worked and sent us this AMAZING VIDEO to showhow impressivehisresults were. Click Here to see the full story and watch his impressive video.

Dennis M. Lox, M.D. has applied his personal interest in sports medicine. As a World Renowned Stem Cell Pioneer. Dr. Lox helps elite athletes improve their functional level so they may return to sports.

Many patients are turning to stem cell therapy as a means of nonsurgical joint pain relief when their mobility and quality of life are severely affected by conditions like osteoarthritis, torn tendons, and injured ligaments. Dennis M. Lox, M.D. specializes in this progressive, innovative treatment that may be able to help you return to an active, fulfilling life.

Each week, Dr. Dennis Lox receives inquiries from aroundthe worldregarding stem cell therapy.

TRAVEL ARRANGEMENTS CAN BE MADE FOR YOU LOCAL OR INTERNATIONAL

Visit our Press Room

Stem cell therapy for joint injuries and osteoarthritis is suited for many individuals, fromprofessional athletes to active seniors. Adult mesenchymal stem cells, not embryonic stem cells, are used in this procedure, which is performed right in the comfort of Dr. Loxs state-of-the-art clinic. The cells are simply extracted from the patients own body (typically from bone marrow or adipose/ fat tissue), processed in our office, and injected directly into the site of injury. Conditions that can be addressed with stem cell treatment include osteoarthritis, degenerative disc disease, knee joint issues (such as meniscus tears), shoulder damage (such as rotator cuff injuries), hip problems (such as labral tears), and tendonitis, among others. For many patients, a stem cell procedure in the knee, hip, shoulder, or another area of the body relieves pain, increases mobility, and may be able to delay or eliminate the need for more aggressive treatments like joint replacement surgery.

If you have questions about adult stem cell therapy for joint injuries and arthritis, how the procedure is performed, and how the stem cells work to repair injured joints and tissues, Dr. Lox would be happy to educate you about the entire process.

Dr. Lox | Dr Dennis Lox

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Dr Lox - Florida Tampa Stem Cell Therapy | PRP | Knee

University of North Carolina Health Careresearchers have made strides toward a stem cell treatment for lung diseases such as pulmonary fibrosis, COPD, and cystic fibrosis.

In fact, they are discussing the start of clinical trials with regulatory authorities.

The team discussed its work in two recent studies. One provedthat it is possible to isolate lung stem cells with a relatively non-invasive procedure. The other showed that stem cells reduce fibrosis in rats with pulmonary fibrosis.

The first study, in the journal Respiratory Research, was titledDerivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies.The second, inStem Cells Translational Medicine, was Safety and Efficacy of Allogeneic Lung Spheroid Cells in a Mismatched Rat Model of Pulmonary Fibrosis.

This is the first time anyone has generated potentially therapeutic lung stem cells from minimally invasive biopsy specimens, Dr. Jason Lobo, director of the universitys lung transplant and interstitial lung disease program,said in a press release. Hewas co-senior author of both studies.

We think the properties of these cells make them potentially therapeutic for a wide range of lung fibrosis diseases, added Dr. Ke Cheng, who led the studies with Lobo. He is anassociate professor in North Carolina State Universitys Department of Molecular Biomedical Sciences.

The research team had previously homed in on stem and support cells they could isolate from a lung tissue sample and grow in a lab. The tissue formed sphere-like structures in a lab dish, prompting the scientists to call them lung spheroid cells.

In 2015, the team showed that these cells had potent regenerative properties in animals with lung diseases. In fact, the stem cells they cultivated outperformed another type called mesenchymal stem cells.

Their latest project involved gathering lung spheroid cells from patients with various lung diseases. They used a procedure calleda transbronchial biopsy thatcan be done in a doctors office.

We snip tiny, seed-sized samples of airway tissue using a bronchoscope, Lobo said. This method involves far less risk to the patient than does a standard, chest-penetrating surgical biopsy of lung tissue.

From this tiny piece of airway, researchers gathered stem cells, then allowed them to multiply because stem cell treatments require infusions of millions of such cells.

When they injected the cells intravenously into mice, the discovered that most found their way into the animals lungs.

These cells are from the lung, and so in a sense theyre happiest, so to speak, living and working in the lung, Cheng said.

The team then tested the treatment in rats exposed to a chemical that triggers lung fibrosis. The lung spheroid cells gave rise to healthy lung cells, reducing both inflammation and fibrosis in the animals lungs.

Also, the treatment was safe and effective whether the lung spheroid cells were derived from the recipients own lungs or from the lungs of an unrelated strain of rats, Lobo said. In other words, even if the donated stem cells were foreign, they did not provoke a harmful immune reaction in the recipient animals, as transplanted tissue normally does.

The researchers said that in humans their goal would be to use patients own stem cells to minimize the risk of immune reactions. But because large quantities of cells are needed, it might be necessary to gather cells from healthy volunteers or organ donation networks as well.

Our vision is that we will eventually set up a universal cell donor bank, Cheng said.

The team is in discussions with the U.S. Food and Drug Administration aimed at starting the first human study by years end. The first trial would include a small group of pulmonary fibrosis patients. The team also hopes their spheroid stem cell therapy will help patients with other lung diseases.

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Trial of Lung Disease Stem Cell Therapy Could Come by Year's End - Lung Disease News

According to data released by the Food and Waterborne Diseases Office of the Health Ministry, an average of 15% of hospital patients suffer from nosocomial infections. A nosocomial infection is an infection acquired in hospital by a patient who was admitted for a reason other than the infection. The severity of hospital-acquired infections depends on the location and type of infection, said Abbasali Imani Fouladi, the scientific secretary of the 18th International Congress of Microbiology, which will be held on Aug. 29-31 at Tehran University of Medical Sciences, ISNA reported. The use of stem cells and their significant role in treatment of the infectionsin particular, antibiotic-resistant infectionsis a key topic that will be discussed by domestic and foreign specialists at the conference. Sometimes ulcers which are resistant to conventional treatment, respond positively and swiftly to stem cell treatments, he explained, adding that officials from Council for Stem Cell Sciences and Technologies (affiliated to Vice-Presidency for Science and Technology) have been invited to the event that will be attended by scientists from Spain, Italy, UK, and France. Four workshops will be held on the sidelines of the meeting. Stating that with resistance to antibiotics becoming more common, there is greater need for alternative treatments, he said, Currently there are 12 strains of bacteria in need of new antibiotics or alternative treatments. The event is co-sponsored by the Health Ministry, TUMS, Pasteur Institute of Iran, Razi Vaccine and Serum Research Institute, and Ilam University of Medical Sciences, according to the congress website (ismcongress.ir). Nosocomial infections occur worldwide and affect both developed and resource-poor countries. Healthcare-associated infections are among the major causes of death and increased morbidity among hospitalized patients. They are a significant burden both for the patient and public health. According to the World Health Organization, HAIs add to functional disability and emotional stress of the patient and may in some cases, lead to disabling conditions that reduce the quality of life. Nosocomial infections are also one of the leading causes of death. The economic costs are considerable. The increased length of hospital stay for infected patients is the greatest contributor to cost. While the prevalence rate of HAIs is 30% in lower-income countries, the average rate is around 6-11% in developed countries, according to Dr. Hossein Masumi-Asl, head of the Food and Waterborne Diseases Office. The most frequent nosocomial infections are infections of surgical wounds, urinary tract infections and lower respiratory tract infections, he said. According to the official, the highest prevalence of nosocomial infections occurs in intensive care units and in acute surgical and orthopedic wards. Infection rates are higher among patients with increased susceptibility because of old age, underlying disease, or chemotherapy.

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Stem Cell Therapy for Infections by Resilient Bacteria - Financial Tribune

Len Richard (left) and actor Terrance Howard on the set of "Empire" in 2015. View Full Caption

Provided by Len Richard

CHICAGO Len Richard used to fight in movie scenes as a stuntman, but now hes fighting for his life.

Diagnosed with liver disease in 2009, hes been placed on the liver and kidney transplant list to replace his rapidly failing organs. Hes opted to have stem cell replacement therapy in place of the transplant, but his insurance wont cover it, so hes raising $10,000 through YouCaring.

The 44-year-old Englewood native said hes desperate to live a healthy life and doesnt want to risk trying the transplant. Theres the fear that the new organs wont work for long and hell constantly get sick from the anti-rejection medications hell have to take, he said.

Once I understood how stem cell works and how it cures people, it was a no-brainer, Richard said. I rather do that than have someone's organs.

More than 5,000 liver transplants in the United States take place each year, according to the "Stem Cell Therapy for Liver Diseases," a review article published in the Journal of Stem Cell Research and Therapy. About 20,000 people are waiting for a transplant, but only 7,000 procedures are performed each year, and up to 1,500 patients die each year waiting.

Use of stem cells to cure liver diseases has been proved beneficial in most of the conditions, according to the article. Scientific literature reveals the role of stem cells in treatment and cure of various diseases like liver cirrhosis, end stage liver failure, genetic liver disease and also the liver cancer. The stem cells possess the ability to renew and multiply by them or stem cells possess special characteristics of regenerating themselves.

Besides being hospitalized twice in eighth grade for a high fever and an enlarged liver and spleen, Richard has lived a fairly healthy life, he said. He had no major health problems in high school or college.

As an adult, he worked behind the scenes in the control room at Channel 50, before moving to Los Angeles in 1998 for a similar television job. Thats when his life changed.

He was at a gym working out and got invited to train with a group who worked as stuntmen, he said.

A stunt coordinator saw me and said that I looked like Omar and Cuba Gooding, Richard said. He hired me for 'Baby Boy.' Thats how I got into doing stunts.

That job led to other jobs in major films, including "Barbershop" and "Transformers."

Everything was going well for Richard, he said, until 2008 when he tore his rotator cuff during filming for the movie "First Sunday," starring Ice Cube and Katt Williams.

I had surgery, and the person I was seeing at the time noticed that I started losing weight and was going to the bathroom a lot, Richard said.

When he went to the doctor for a routine checkup, he learned that he was diabetic. The doctor reviewed his medical history and asked if he has ever been evaluated for a liver transplant.

In 1987, when he was 13, he mysteriously became ill, he said. He was in the hospital for a high fever and the doctors noticed that his liver and spleen were enlarged, but didnt know why. He was sent home only to return a few days later.

I spent the whole summer in the hospital, Richard said. They did exploratory abdominal surgery and took a sample of all of my organs. They sent it to the CDC and other labs and came back with nothing.

Now that hes on the transplant list, Richard is hoping that hes able to raise enough money to travel to see a doctor in Mexico who was recommended by another patient and have the alternative procedure instead.

I want to avoid the transplant and keep my organs, Richard said.

He said he misses his old life, although he did more recently work on the show "Empire." Hes on disability now, but wants to return to work and the gym.

I was always in the gym, used to go hiking a lot, but now I work out when I feel like it, he said. I have low energy, and its kind of hard right now. I'll ride a bike and try to do air squats, but I was doing crossfit before it became too much for me.

Nobody wants to be sick. Id like to be back in California, moving around. I just get tired of going to doctor, getting poked and having having them tell me I need a transplant. Its mentally draining, and it's scary.

Continued here:

Former Hollywood Stuntman Raising $10000 For His Stem Cell Therapy - DNAinfo

Forever Labs, a startup in Y Combinators latest batch, is preserving adult stem cells with the aim to help you live longer and healthier.

Stem cells have the potential to become any type of cell needed in the body. Its very helpful to have younger stem cells from your own body on hand should you ever need some type of medical intervention, like a bone marrow transplant as the risk of rejection is greatly reduced when the cells are yours.

Mark Katakowski spent the last 15 years studying stem cells. What he found is that not only do we have less of them the older we get, but they also lose their function as we age.So, he and his co-founders Edward Cibor and Steve Clausnitzer started looking at how to bank them while they were young.

Clausnitzer banked his cells two years ago at the age of 38. So, while he is biologically now age 40, his cells remain the age in which they were harvested or as he calls it, stem cell time travel.

Steven Clausnitzer with his 38-year-old banked stem cells.

Stem cell banking isnt new. In fact, a lot of parents are now opting to store their babys stem cells through cord blood banking. But thats for newborns. For adults, its not so common, and theres a lot of snake oil out there, Clausnitzer cautions.

There are places offering stem cell therapy and Botox, he said.

Forever Labs is backed by a team of Ivy League-trained scientists with decades of experience between them. Jason Camm, chief medical officer for Thiel Capital, is also one of the companys medical advisors however, the startup is quick to point out it is not associated with Thiel Capital.

The process involves using a patented device to collect the cells. Forever Labs can then grow and bank your cells for $2,500, plus another $250 for storage per year (or a flat fee of $7,000 for life).

The startup is FDA-approved to bank these cells and is offering the service in seven states. What it does not have FDA approval for is the modification of those cells for rejuvenation therapy.

Katakowski refers to what the company is doing as longevity as a service, with the goal being to eventually take your banked cells and modify them to reverse the biological clock.

But that may take a few years. There are hundreds of clinical trials looking at stem cell uses right now. Forever Labs has also proposed its own clinical trial to take your stem cells and give them to your older cells.

Youll essentially young-blood effect yourself, Katakowski joked of course, in this case, youd be using your own blood made from your own stem cells, not the blood of random teens.

More:

Forever Labs preserves young stem cells to prevent your older self ... - TechCrunch

Glen Stubbe - Star Tribune The Mayo Clinic expects a surge of hundreds of cancer patients per year if CAR T is approved, because it will initially be provided by large medical centers that have experience with the therapy and its side effects.

Researchers at the Mayo Clinic and the University of Minnesota say theyre on the brink of a new era in cancer care one in which doctors extract a patients white blood cells, have them genetically engineered in a lab, and put them back to become personalized cancer-fighting machines.

The so-called CAR T cellular therapies are expected to receive federal approval this fall for certain rare blood cancers B-cell forms of lymphoma and leukemia. But scientists at the Minnesota institutions hope thats just the first step that will lead to better treatment of solid tumor cancers as well.

This is really the first approval of a genetically modified product for cancer therapy, said Dr. Jeffrey Miller, deputy director of the Masonic Cancer Center at the University of Minnesota. If the proof of concept works, he said, we might be on the right track to get away from all of that toxic chemotherapy that people hate.

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Mayo Clinic, University of Minnesota develop 'robocop' stem cells to fight cancer - Minneapolis Star Tribune

At Neuropathy & Pain Centers of Texas, non-invasive medical procedures are the mainstay of our practice. Using the most up to date techniques, our staff treats patients as whole people, providing a comprehensive diagnostic assessment in order to design a customized strategy for relief from medical concerns in the Dallas/Fort Worth area. The technology has advanced to a point that, at Neuropathy & Pain Centers of Texas, we apply stem cell treatments designed to help our patients attain their wellness goals and achieve a higher quality of life.

For instance, until recently, treatment options for people with osteoarthritis of the knee were limited. Steroid injections, joint replacement surgery, and physical therapy were often the only treatment options. Now, regenerative injections for knee osteoarthritis are available at Neuropathy & Pain Centers of Texas. Regenerative cellular therapy also has applications for treating Achilles tendonitis, rotator cuff tendonitis, and degenerative arthritis.

These injections work with the bodys natural ability to heal itself. Unlike treatments that simply address the symptoms, stem cell therapy actually promotes repair of the body, restoring degenerated tissue. Stem cell injections also contain hyaluronan, which eases pain and restores mobility by lubricating joints and tendons. This therapy fits well with Neuropathy & Pain Centers of Texass integrated approach to wellness, addressing the source of issues, rather than just treating the symptoms.

Continued here:

Stem Cell Therapy - Neuropathy & Pain Centers of Texas

Its human nature to want a quick fix in resolving issues or problems. Getting maximum results with minimal effort certainly has its appeal. From Thigh Masters and Bowflexes to The Clapper and Ginsu knives, the promise for rapid results and convenience can draw consumers in like the late-night glow of the TV infomercials selling these items.

But, lets be honest, these examples may have yield their desired results, but most products end up being a total disappointment and waste of money. This is also the case with certain medical procedures or therapies claiming to fix certain ailments or chronic conditions. As a patient-consumer, its important to do your research and not let emotions or false hopes guide you into making a potentially expensive or even risky decision involving your health.

One item in general, stem cell therapy, has been getting quite a bit of attention of late. Many may ask, what are stem cells? Stem cells are cells that have the potential to develop into many different types of cells. Think of them as a blank canvas which can divide and become specialized cells within the body such as blood, liver, or muscle cells. Stem cell therapy acts by introducing these cells into some areas of the body, to which the stem cells can divide regularly to regenerate and/or repair existing tissue. Stem cell therapy has long been used by physicians to treat certain types of cancers, such as leukemia and lymphoma as well as treating some bone, skin, and corneal eye injuries. But, while stem cells continue to be studied as potential treatments for other ailments and conditions, there are very few of these treatments currently that have been proven to be effectivelet alone safe.

With catchy, even gimmicky, tag lines like make me walk again, feel young again, or no surgery, no side effects, clinics (both in the United States and outside of it) are offering stem cell therapy to treat a laundry list of conditions. The problem with it is patient testimonials and gimmicky marketing techniques can be misleading. One resource beneficial in better understanding stem cell therapies is the International Society for Stem Cell Research (ISSCR). It represents academia and industry on a broad range of issues that affect the well-being of patients and their families, and strives to educate the public and government regulators on the basic principles of stem cell science and the realistic potential for new medical treatments and cures.

According to the ISSCR, when there is no existing or effective treatment for a disease or condition it is easy to understand why you may feel there is nothing to lose from trying something new, even if it isnt proven. Unfortunately, most of the unproven stem cell treatments for sale throughout the world carry very little promise of actual benefit and very real risks.

Many stem cell therapy clinics may offer the use of a patients own cells, also known an autologous transplant. In theory, your immune system would not attack your own cells if they were used in a transplant. However, the processes by which the cells were acquired, grown and then reintroduced into the body would carry risks. Here are just a few known risks of autologous stem cell treatments:

If you have thought about or are considering stem cell therapy, first get the guidance of your primary healthcare provider. They can help guide you in obtaining the right literature and evidence in help making the right decision for the safest and most effective treatments available. Snake oil salesmen exist in every industryincluding those wearing white lab coats. Choose your care wisely.

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STONE: Certain medical practices can prey on false hopes - Odessa American

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Stem cell therapy could be used to promote hair growth in people with either baldness or alopecia.

Stem cells may have a part to play in regrowing everything from teeth to eyeballs, and now researchers at UCLA are working on something that would be welcomed by people suffering from a very common problem regrowing hair in bald people. In new research, they describe a new way to activate the stem cells in the hair follicle to make new hair sprout. Such a breakthrough could potentially be used to develop drugs for promoting hair growth in people with either baldness or alopecia.

We found that hair follicle stem cells practice a distinct type of metabolism, and that if you fiddle with it genetically or pharmacologically, you can control the rate at which these cells wake up to make new hair shafts, Bill Lowry, a professor of molecular, cell, and developmental biology at UCLA, told Digital Trends.

Hair follicle stem cells generate hair over an individuals lifetime. These remain dormant much of the time, but activate quickly when a new hair cycle prompts growth. When they dont activate, baldness occurs.In small animal studies, the team was able to identify two drugs that influence hair follicle growth when applied to the skin. One drug is named RCGD423, and works by activating a cellular-signaling pathway that transmits information from outside the cell to the cells nucleus. The other drug, called UK5099, works by forcing the production of lactate in hair follicle stem cells, thereby accelerating hair growth.

We showed that drugs that promote production of a particular metabolite can accelerate hair follicle stem cell activation in mice, Lowry said. We are pushing forward toward the clinic to determine if this same approach is viable for human hair in patients with thinning due to stress, age, chemotherapy, [and] hormone imbalance.

There is still more work to be done before that point can be reached. As of now, the experimental drugs have not been tested in humans, nor approved as safe by the Food and Drug Administration. Researchers are optimistic that it will reach that point.We are considering starting a new company to support the ongoing development of new compounds that could be drugs for testing in a clinical trial, Lowry said.

A paper describing the research was recently published in the journal Nature Cell Biology.

View post:

Stem cell therapy work could solve hairy problem, banish baldness for good - Digital Trends

Forever Labs, a startup in Y Combinators latest batch, is preserving adult stem cells with the aim to help you live longer and healthier.

Stem cells have the potential to become any type of cell needed in the body. Its very helpful to have younger stem cells from your own body on hand should you ever need some type of medical intervention, like a bone marrow transplant as the risk of rejection is greatly reduced when the cells are yours.

Mark Katakowski spent the last 15 years studying stem cells. What he found is that not only do we have less of them the older we get, but they also lose their function as we age.So, he and his co-founders Edward Cibor and Steve Clausnitzer started looking at how to bank them while they were young.

Clausnitzer banked his cells two years ago at the age of 38. So, while he is biologically now age 40, his cells remain the age in which they were harvested or as he calls it, stem cell time travel.

Steven Clausnitzer with his 38-year-old banked stem cells.

Stem cell banking isnt new. In fact, a lot of parents are now opting to store their babys stem cells through cord blood banking. But thats for newborns. For adults, its not so common, and theres a lot of snake oil out there, Clausnitzer cautions.

There are places offering stem cell therapy and Botox, he said.

Forever Labs is backed by a team of Ivy League-trained scientists with decades of experience between them. Jason Camm, chief medical officer for Thiel Capital, is also one of the companys medical advisors however, the startup is quick to point out it is not associated with Thiel Capital.

The process involves using a patented device to collect the cells. Forever Labs can then grow and bank your cells for $2,500, plus another $250 for storage per year (or a flat fee of $7,000 for life).

The startup is FDA-approved to bank these cells and is offering the service in seven states. What it does not have FDA approval for is the modification of those cells for rejuvenation therapy.

Katakowski refers to what the company is doing as longevity as a service, with the goal being to eventually take your banked cells and modify them to reverse the biological clock.

But that may take a few years. There are hundreds of clinical trials looking at stem cell uses right now. Forever Labs has also proposed its own clinical trial to take your stem cells and give them to your older cells.

Youll essentially young-blood effect yourself, Katakowski joked of course, in this case, youd be using your own blood made from your own stem cells, not the blood of random teens.

Read more from the original source:

Forever Labs preserves young stem cells to prevent your older self from aging - TechCrunch

By: PTI | Los Angeles | Published:August 15, 2017 6:54 pm Understanding the critical role metabolism plays in hair growth and stem cells.

Scientists have discovered a new way to activate the stem cells in the hair follicle, an advance that may pave the way for novel drugs to promote hair growth. Hair follicle stem cells are long-lived cells in the hair follicle; they are present in the skin and produce hair throughout a persons lifetime. They are quiescent, meaning they are normally inactive, but they quickly activate during a new hair cycle, which is when new hair growth occurs.

The quiescence of hair follicle stem cells is regulated by many factors. In certain cases they fail to activate, which is what causes hair loss.

Researchers from University of California, Los Angeles in the US found that hair follicle stem cell metabolism is different from other cells of the skin. Cellular metabolism involves the breakdown of the nutrients needed for cells to divide, make energy and respond to their environment. The process of metabolism uses enzymes that alter these nutrients to produce metabolites.

As hair follicle stem cells consume the nutrient glucose a form of sugar from the bloodstream, they process the glucose to eventually produce a metabolite called pyruvate. The cells then can either send pyruvate to their mitochondria the part of the cell that creates energy or can convert pyruvate into another metabolite called lactate. Our observations about hair follicle stem cell metabolism prompted us to examine whether genetically diminishing the entry of pyruvate into the mitochondria would force hair follicle stem cells to make more lactate, and if that would activate the cells and grow hair more quickly, said Heather Christofk, an associate professor at UCLA.

The research team first blocked the production of lactate genetically in mice and showed that this prevented hair follicle stem cell activation. Conversely, they increased lactate production genetically in the mice and this accelerated hair follicle stem cell activation, increasing the hair cycle. Before this, no one knew that increasing or decreasing the lactate would have an effect on hair follicle stem cells, said William Lowry, a professor at the UCLA.

Once we saw how altering lactate production in the mice influenced hair growth, it led us to look for potential drugs that could be applied to the skin and have the same effect, said Lowry. The team identified two drugs that, when applied to the skin of mice, influenced hair follicle stem cells in distinct ways to promote lactate production.

The first drug, called RCGD423, activates a cellular signalling pathway called JAK-Stat, which transmits information from outside the cell to the nucleus of the cell. The research showed that JAK-Stat activation leads to the increased production of lactate and this in turn drives hair follicle stem cell activation and quicker hair growth. The other drug, called UK5099, blocks pyruvate from entering the mitochondria, which forces the production of lactate in the hair follicle stem cells and accelerates hair growth in mice.

Through this study, we gained a lot of interesting insight into new ways to activate stem cells, said Aimee Flores, first author of the study published in the journal Nature Cell Biology. The idea of using drugs to stimulate hair growth through hair follicle stem cells is very promising given how many millions of people, both men and women, deal with hair loss, said Flores.

I think weve only just begun to understand the critical role metabolism plays in hair growth and stem cells in general; Im looking forward to the potential application of these new findings for hair loss and beyond, she said.

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Potential stem cell therapy may help promote hair growth - The Indian Express

BOSTON (AP) In his offices at Boston Childrens Hospital, Leonard Zon is busily developing cutting-edge stem cell therapies surrounded by fellow researchers, lab equipment and 300,000 striped, transparent zebrafish.

Zons lab and the zebrafish are the results of an initiative begun nearly a decade ago to make Massachusetts one of the countrys premier life sciences incubators.

That 2008 initiative, signed by former Democratic Gov. Deval Patrick, committed Massachusetts to spending $1 billion over 10 years to jump-start the life sciences sector attracting the best minds, research facilities and the venture capital funding.

By most yardsticks, Patricks gamble has paid off. Massachusetts, and the greater Boston area in particular, are now seen as a top life sciences hub.

For Zon, and other life sciences leaders, the support has been transformative.

In 2013, the Massachusetts Life Sciences Center, which is charged with disbursing the funds, awarded a $4 million grant to Childrens Hospital to help establish the Childrens Center for Cell Therapy. Some of the money went toward replacing the original aquaculture facilities at Zons lab with state-of-the-art systems.

Zon said the changes helped him pursue stem cell therapies taking tissues grown from stem cells aimed at thwarting specific diseases and transplanting them into a diseased organ. Zon said his lab helped develop a drug for treating a blood disease known as Diamond Blackfan anemia in part by developing zebrafish models of the disease.

Massachusetts is the best place in the world for biotechnology, he said. Its been life-changing for us.

Zons experience isnt unique.

NxStage Medical, Inc., a medical technology company founded in 1998 in Lawrence focused on end-stage renal disease and acute kidney failure, received nearly $1.8 million in tax incentives through the program. In 2013, Woburn-based Bio2 Technologies received $1 million in loan financing, helping it develop bone graft substitute implants.

The states reputation as a magnet for life sciences also can be seen in the surge of construction in Boston and Cambridge, particularly around the Kendall Square area, where glass-lined office and research buildings have sprouted.

Travis McCready, CEO of the Massachusetts Life Sciences Center, also pointed to the influx of grant money from the National Institutes of Health and funds from world-class academic and research institutions.

By pretty much any measure we are considered the leading life sciences ecosystem in the U.S., and among the leading ecosystems in the world, McCready said.

McCready said the 2008 initiative helped create a framework for that growth, even as he acknowledged that not every company or research effort that receives funding succeeds.

Some of these startups are going to fail, but ideas will be tested and intellectual property will be created, he said. Failure is not a negative.

McCready said a top goal of the program is to develop the next generation of researchers. The center funds over 500 life sciences internships each year with about a quarter of those landing full-time jobs at the company where they interned.

He said that talent pool is critical to the next stage in the life science revolution: bio-manufacturing and digital health.

Bio-manufacturing refers to the ability of research labs and life science companies to take their breakthroughs and start manufacturing them on a large scale. He pointed to a decision by Kendall Square-based Alnylam Pharmaceuticals to open a 200,000-square-foot (18,580 square meter) manufacturing space in Norton, just 45 minutes away.

He said the state also is hoping to builds up the digital health sector, where large sets of scientific data are used to look for new therapies and how best to deliver those medicines inexpensively.

Today we are the undisputed global leader in the field, Patrick said this week in a statement to The Associated Press. Public investment not only catalyzed hundreds of millions of dollars in private investment and created thousands of jobs, but contributes meaningfully to the development of life changing treatments and cures for people around the world.

Republican Gov. Charlie Baker is hoping to build on the initiative. In June, Baker announced a proposal to dedicate $500 million over five years to continue strengthening the life sciences with a focus on public infrastructure, research and development, workforce training and education. Baker said he will be supporting the public-private partnerships and strategic investments that have made Massachusetts a global leader in the life sciences.

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Life Science investment paying dividends - The Recorder