Global Chiropractic Medicine Market to Record Exponential Compound Annual Growth Rate in the Coming Years – Cole of Duty

Chiropractic Medicine is an alternate form of medicine used in the diagnosis and treatment of diseases associated with the musculoskeletal system by using hands-on spinal manipulation and other alternative techniques. Chiropractic medicine is primarily used as an alternative to pain relief for muscles, joints, bones, or connective tissue. It can also be used sometimes in combination with the conventional medical treatment. The common and well known therapeutic procedures performed by chiropractic doctors is spinal manipulation. The technique of chiropractic medicine focuses on enabling the body to heal itself without surgery and conventional medication by restoring the mobility of joints which got restricted by tissue injury due to a traumatic event.

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The goal of chiropractic medicine is to correct alignment problems, relaxes body and support bodys natural ability to heal itself. Chiropractic doctors evaluate patients through the medical examination, laboratory tests, x-rays, etc. and after taking the complete history and diagnosing a patient, the doctor describes the comprehensive treatment plan and recommend therapeutic exercise along with nutritional, dietary and lifestyle counselling. The chiropractic medicine is used to compliment or support the medical treatment but in many cases, the chiropractic therapy may be the principal method of treatment.

Chiropractic Medicine Market: Drivers & Restraints

The main driving factor for the chiropractic medicine market is the relief from taking medications. Multiple studies also prove the safety of chiropractic treatments than any other commonly used medical treatments; including medications, injections and surgeries for similar conditions. These factors also drive the market for chiropractic medicine market. Along with this, increasing geriatric population, increasing openness to alternative medicines and rise in disposable income also supports the market of chiropractic medicines. However, several side effects associated with the treatment, such as, aching or soreness in the spinal joints or muscles, may restrict the market growth. Unavailability of services in low and middle income countries also restrain the global chiropractic medicine market growth.

Chiropractic Medicine market: Segmentation

By Disease Type:

By Age Group:

By End Users

The cost of chiropractic services varies from region to region and form the service type. It is one of the major three healing professions of western world. Chiropractic physicians are trained in providing diagnostic, therapeutic & rehabilitative services along with nutritional, dietary and lifestyle counselling. In context to the rising healthcare costs, the chiropractic medicine can also be seen as an inexpensive and relatively effective treatment method. The market for chiropractic medicines is growing with increasing networking and proven results. The approach followed by one practitioner decides its sales performance and helps in developing customer base.

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Geographically, the market for chiropractic medicine can be segmented into five regions, North America, Latin America, Europe, Asia Pacific and Middle East & Africa. North America has the highest market share in the global chiropractic medicine owing to the easy access to services and favorable reimbursement scenario. There are over 70,000 licensed chiropractors working in the United States today. This is followed by the European market due to the existence of many healthcare facilities providing chiropractic medicine services. Asia Pacific is expected to represent a stable growth rate during the forecast period supported by the increasing investment in healthcare facilities and rise in the healthcare spending. Latin America followed by MEA represents a slow growth rate in the chiropractic medicines market because of the out of pocket spending and less availability of these services in the region.

Some of the service providers in the chiropractic medicine include Back to Natural Chiropractic, Alberta Blue Cross, Dr. Spine Clinic, Hampstead Chiropractic Clinic, ChiroMatrix, Manors Chiropractic Clinic, Complete Care Chiropractic and Jandakot Chiropractic Clinic etc. There are however not any international service provider in the chiropractic medicine and vary from region to region.

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Global Chiropractic Medicine Market to Record Exponential Compound Annual Growth Rate in the Coming Years - Cole of Duty

Electroceuticals/Bioelectric Medicine Market to Witness Huge Growth by 2026 with Top Key Players Medtronic, Boston Scientific Corporation, St. Jude…

Electroceuticals/Bioelectric Medicine Marketresearch is an intelligence report with meticulous efforts undertaken to study the right and valuable information. The data which has been looked upon is done considering both, the existing top players and the upcoming competitors. Business strategies of the key players and the new entering market industries are studied in detail. Well explained SWOT analysis, revenue share and contact information are shared in this report analysis.

Electroceuticals/Bioelectric Medicine Market is growing at a High CAGR during the forecast period 2020-2026. The increasing interest of the individuals in this industry is that the major reason for the expansion of this market.

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Top Key Players Profiled in This Report:

Medtronic, Boston Scientific Corporation, St. Jude Medical, Cochlear, LivaNova PLC, Sonova, BIOTRONIK, SECOND SIGHT, Nevro Corp, and electroCore.

The key questions answered in this report:

Various factors are responsible for the markets growth trajectory, which are studied at length in the report. In addition, the report lists down the restraints that are posing threat to the global Electroceuticals/Bioelectric Medicine market. It also gauges the bargaining power of suppliers and buyers, threat from new entrants and product substitute, and the degree of competition prevailing in the market. The influence of the latest government guidelines is also analyzed in detail in the report. It studies the Electroceuticals/Bioelectric Medicine markets trajectory between forecast periods.

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The Electroceuticals/Bioelectric Medicine Market report also covers a detailed comprehension of the major geographies present in the market along with the key segments and sub-segments. The report focuses on regional development status, which includes the market size, share and volume. Additionally, this report covers the manufacturers data, including business distribution, cost and price, margin and gross revenue. This allows a reader to understand consumers behavior and a better understanding about the leading competitors operation in the market.

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Table of Contents

Global Electroceuticals/Bioelectric Medicine Market Research Report 2020 2026

Chapter 1 Global Electroceuticals/Bioelectric Medicine Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Production, Revenue (Value) by Region

Chapter 5 Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6 Global Production, Revenue (Value), Price Trend by Type

Chapter 7 Global Market Analysis by Application

Chapter 8 Manufacturing Cost Analysis

Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10 Marketing Strategy Analysis, Distributors/Traders

Chapter 11 Market Effect Factors Analysis

Chapter 12 Global Electroceuticals/Bioelectric Medicine Market Forecast

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Medicine Hat Mural Fest running all summer this year – CHAT News Today

Organizer Jeff Goring said sponsors like McBrides Bakery and Sun City Ford were quick to reach out and offer support.

It was just cool to see the sponsors from last year some of the other sponsors really jump on board and say were willing to make something happen and we were able to pull it together, he said.

New murals have already been painted on the Sixth Avenue side of The Page & Whisker, at the old Towne Theatre and on Second Street across from Station Coffee Co.

The Page & Whisker mural was done by Chad Tyson, founder and CEO of The Paint Factory. He says he wanted to complement the age of the building, which is one of the citys oldest, and painted an old pub-style sign the reads The Hat.

Future murals will spruce up other downtown buildings over the summer, with two more planned for both July and August and more to finish up in September.

Goring, also known as Sonz1, says locations are still being locked down.

Working with building owners, making sure we got the right locations, make sure were not going over any historical locations. A lot of times with the locations we try to make sure we find old, kind of ones that have been tagged up or ones that are in high traffic areas that will really bring a benefit to the downtown.

Goring said this year he wants to highlight local artists, splitting the murals between them and artists he hopes to bring in from other parts of the country, like Tyson from Toronto.

We have some phenomenal artists here in the Hat, so were thankful for that, he said.

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Medicine Hat Mural Fest running all summer this year - CHAT News Today

Art and medicine: Looking at the role of portraiture in health care – American Medical Association

There are artistic representations of medicine and illness in anatomical and physiological illustrations of the human body, medical instruction manuals, treatment documentation and aesthetic works. These have facilitated discovery and understanding for different parts of medicine, health, illness and disability.

In particular, the use of portraits can be instrumental in representing and explaining medical pathologies, pathopsychologies and trauma. Portraiture in health care can be used to introduce innovative strategies for perceiving ethical and aesthetic value. Most importantly, it can also motivate deeper and fuller understanding of the experiences of patients, physicians and others in health care.

The June issue ofAMA Journal of Ethics(@JournalofEthics) features numerous perspectives on portraiture in health care and gives you an opportunity to earn CME credit.

Articles include:

In the journals June podcast, expert James Van Arsdall, EdD, social science faculty at Metropolitan Community College in Omaha, Nebraska and an advanced trauma life support educator for the American College of Surgeons, shares his experience of sitting for a portrait after his treatment for oral cancer.

Mark Gilbert, PhD, is an artist and a researcher associated with the Faculty of Medicine at Dalhousie University in Halifax, Nova Scotia, Canada. On the podcast, Gilbert discusses how he came to do portraiture in clinical settings.

Listen toor watchprevious episodesof the podcast, Ethics Talk, or subscribe iniTunesor other services.

TheAMAJournal of EthicsCME modules, How Portraiture Can Help Build Therapeutic Capacity in Patient-Clinician Relationshipsand Ethics Talk: Portraiture in Clinical Contexts, areeachdesignated by the AMA for a maximum of 0.5AMA PRA Category 1 Credit.

The offerings are part of theAMA EdHub, an online platform that brings together high-quality CME, maintenance of certification, and educational contentin one placewith relevant learning activities, automated credit tracking and reporting for some states and specialty boards.

Learn more aboutAMA CME accreditation.

The journals editorial focus is on commentaries and articles that offer practical advice and insights for medical students and physicians.Submit a manuscriptfor publication.

The 2020 JohnConley Ethics Essay Contestand theConley Art of Medicine Contestare now open for submission. Read the essay prompt and see visual media requirements on theAMA Journal of Ethicswebsite.

Apply to become a theme issue editorto help the journal develop theme issues on interested and neglected topics.

Visit the journalsCOVID-19 Ethics Resource Centerfor articles, podcasts, and videos relevant to the ethical challenges of the current pandemic.

Upcoming issues of theAMA Journal of Ethicswill focus on humor in health care as well as opioids and public health.Sign upto receive email alerts when new issues are published.

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Personalization, Prediction and Prevention Drive the Second Transformation of Medicine – BioSpace

The pandemic is a wake-up call to humanity to understand the perils of not appreciating the importance of health and healthcare, said Ralph Snyderman, once dubbed the father of personalized medicine, and chancellor emeritus, Duke University, said during Demy-Coltons first virtual salon, The Future of Healthcare: Innovation, Change and Urgency. He believes it will usher in the second major transformation of medicine.

We knew the importance of health and healthcare, but it wasnt front of mind, he said. Faced with the possibility of losing it, we have stopped dead in our tracks.

Now, the healthcare system is innovating to address the pain points the pandemic revealed. Specifically, it is becoming more proactive, preventative and personalized.

Genomics is making those innovations possible. With whole genome sequencing, its finally clear that health is determined by a combination of genetics, individual actions and exposure to environmental conditions throughout life. As Snyderman said, The improvement of health is a dynamic continuum. It must have the individual at the helm.

Sweeping changes will come in the next decade.

I anticipate the ability to predict an individuals susceptibility to disease, to determine the factors that enhance or diminish that disease, and to track them over time. That will be the second major transformation of medicine, behind germ theory.

Millions of people have had their genomes sequenced, he noted, and wearables are commonplace.

That makes it easy for individuals and their physicians to monitor and track activity, sleep, electrolytes, glucose levels and many other elements of health. Apps even remind patients when to take their medications, thus improving medical compliance. The ability to accumulate, aggregate and analyze massive quantities of data only adds value to the sequencing.

Machine learning, a subset of artificial intelligence (AI), can tease apart the factors that affect health. As this occurs, he pointed out, The ability to predict an individuals health pathway is becoming more and more vivid. When genome sequencing and the aggregation of information from wearables becomes a global phenomenon, predictive healthcare will become more accurate and more powerful.

Snyderman equates the healthcare system of the future to GPS systems in cars today.

Were far from it now, but in 10 years, there will be meaningful tools (to plot personalized pathways) for individuals to navigate their own health, Snyderman said.

Today, concierge medicine plots such pathways for those who can afford it. In the future, with digital tools, that can expand to the much larger middle ground of people.

The health delivery infrastructure will be transformed, too. Were already seeing that.

Until recently, healthcare was delivered by large groups of physicians from specific locations. But, as the COVID-19 pandemic showed, The existing hospital network isnt sustainable for the future. We need to distribute care. While hospitals will continue to be a hub where severe illnesses are treated, Snyderman advocates moving many of the less critical procedures to community hospitals.

CVS and Walgreens, among others, already are embracing the distributed healthcare model by placing primary care clinics in many of their retail stores. CVS is augmenting that with onsite telemedicine. With health advice available through online symptom checkers and Google searches, healthcare clearly is moving online.

This represents a major transfer of power from the provider to the individual, he said, helping patients navigate their own health. In the future, this trend will be much greater, and also is more cost-effective, he added.

The brave new world of healthcare comes with cautions. Research published May 18 in the Medical Journal of Australia found that online symptom checkers were right only 36% of the time.

There also are privacy concerns.

With your health records a part of a large ecosystem, who owns them? Snyderman asked. The Health Insurance Portability and Accountability Act (HIPAA) provides clear guidelines and severe penalties for those sharing patient-identified information beyond the care team, but the rapidly evolving climate around medical information makes it essential to ensure the HIPAA protections remain adequate.

Another concern involves the risk of replacing one monolithic structure with another, as commercial players including multiple healthcare systems, third party payers and digital health partners become involved. Privacy and ethics go hand-in-hand, Snyderman said.

Ultimately, Snyderman predicted a hybrid model will emerge. He envisions virtual caregiver visits for some things and personal visits for others. Theres value to human interaction with a caregiver who knows you and can identify your current health status, proximate risks and ways to mitigate them.

Personalization, prediction and prevention are increasingly possible and will form the basis of the transformation of 21st century medicine that began decades ago with genomic sequencing. The traditional healthcare system is changing as researchers learn more about what drives health and disease. We are learning, Snyderman says, that, Regardless what we do, the most important individual in ones health is oneself.

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Sustained Acoustic Medicine Device sam Offers an Alternative Solution to Pain Medication and Surgery – Yahoo Finance

TRUMBULL, Conn., June 9, 2020 /PRNewswire/ --The advanced sustained acoustic medicine device (sam) from ZetrOZ Systems offers physicians and orthopedic surgeons an alternative solution to pain medication and surgery for their patients. Medical providers can prescribe sam, the only FDA-cleared long-duration ultrasound device, for prescription home-use to treat arthritis and soft tissue injuries.

sam is a non-invasive prescription medical device that is applied over the target injury and delivers a localized treatment. The device is an excellent option for avoiding medication and delaying surgery, as well as improving postoperative healing and surgical outcomes. sam is especially beneficial for patients who struggle with poor healing capability.

In addition to accelerating and improving the healing process, sam is also a very effective treatment for pain arising from conditions such as arthritis, back spasms, disk herniation and tendonitis.

Sixty million people suffer from arthritis and 50 million people struggle with back pain in the United States alone. The leadership team at ZetrOZ Systems set a goal to help 100 million patients who are in pain or facing surgery. sam does not block or mask pain. The device treats the damaged tissue and inflammatory response that causes it, getting to the root of the problem. ZetrOZ Systems believes that not all patients require surgery or medication.

"We want physicians and orthopedic surgeons to know they are not limited in the options they can offer patients. sam gives them a viable, convenient alternative to prescribing drugs or putting patients under the knife," said Dr. George Lewis, chief executive officer of ZetrOZ Systems.

While sam is technologically sophisticated, it is also easy to use and apply, making it the perfect choice for home application by patients. The solution is convenient, as patients can engage in most activities while wearing it. sam ships directly to the patient's home, conserving clinic time and requiring little followup from medical providers.

Medical providers can prescribe sam using a simple Rx form available at samrecover.com. Patients typically undergo treatment for eight to 10 weeks. Each treatment includes the sam device and five to eight packs of ultrasound coupling patches. Those with chronic arthritis pain will continue to use the device beyond 10 weeks to maintain their condition.

About ZetrOZ Systems

ZetrOZ Systems is an FDA cGMP and ISO 13585 medical technology company headquartered in the southern coastal region of Connecticut. The organization also has manufacturing facilities across the United States. ZetrOZ Systems produced UltrOZ, samSport and samPro 2.0 to provide safe and effective treatment options for prevalent conditions such as arthritis. Learn more at zetroz.comand samrecover.com.

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BIO 2020: Cell and Gene Therapies Will Dominate Medicine in 30 Years – BioSpace

One day, cell and gene therapies will be as common as small molecules and antibody-based therapies are today, according to panelists at BIOs June 8 virtual session, The Next Generation of Medicine: Cell Therapies, Gene Therapies and Beyond.

Because cell and gene therapies have the potential to address complex biological issues such as dysregulation, translocation and mutations, they can use that power to change what the body is doing.

So, while small molecules and antibody therapies will still be around 30 years from now, they will be less important. Cell and gene therapies will dominate, James Sabry, global head of pharma partnering at Roche, said.

In focusing on the future of healthcare, Roche is investing in small company innovation. Its deals with Spark Therapeutics and Adaptive Biotechnologies are prime examples of what it seeks to achieve 10, 20 or even 30 years from now.

Were interested not just in the incremental improvements of antibody therapies or small molecules, but in identifying what could be the therapeutic modalities that will dominate the landscape, Sabry said.

That means cell and gene therapies. Already several gene therapies are approved and others are various companies pipelines.

Spark Therapeutics is working extensively in gene therapies for monogenetic disorders, including hemophilia, said Federico Mingozzi, CSO of Spark.

Spark is validating its gene therapy platform approach with the goal of using it against many more complex diseases.

Assuming a long time frame, one could even imagine using the body as a factory for making antibodies, Sabry said. Essentially, it could be possible to one day turn tissues into biofactories.

Adaptive Biotechnologies has taken its approach to immune-drive medicine from diagnostics into therapeutics.

The immune system doesnt make the distinction between therapeutics and diagnostics the way we do, said Harlan Robins, CSO and co-founder, Adaptive Biotechnologies.

His company focuses on T and B cell receptors, which bind to either pathogens or parts of pathogens, or, in the case of cancer, to mutated pieces of genes.

That binding is how the immune system discovers theres a problem, and its also is how it initiates an immune response, Robins said. Therefore, the same molecule is the diagnostic and targeting molecule. Whats distinct, he said, is the horsepower needed to move a therapeutic along in terms of development. Development for therapeutics is much more intense than for diagnostics. In this case, its partner Roche is providing the horsepower.

Next generation vectors are another hurdle to surmount in advancing cell and gene therapies to the next level, where they may tackle more complex diseases.

There are still enormous opportunities to use (our viral capsid) delivery vehicle for nucleic acids to make them more specific, Mingozzi said. There are a lot of ways to make AAVs more potent and drive expression of the therapeutic gene and then make it more controllable.

Improving the delivery platform will open it to new indications.

Eventually, adenoviral vectors (AVVs) likely will be replaced with more efficient (but not yet determined) delivery systems.

If you think about vectors as a delivery system and a genetic payload, you begin to think that are other ways to getting genetic material into a body, Sabry added.

Exosomes are one possibility, but the future may offer a library of different delivery mechanisms.

Sabry envisions a future in which genetic surgery is performed as routinely as anatomic surgery is performed today.

Imagine going in and removing a disease gene and replacing it with a normal gene, he said. Tight targeting could integrate it at the specific location of the disorder gene. Its not out of the realm of the possible.

The limitations of how to soup-up the genetic manipulations, have not yet been reached, panelists agreed. But there are a lot of barriers. Targeting, especially in cancer, remains a hurdle. To overcome that, Robins suggested making the cells themselves more powerful, but acknowledged safety concerns.

Another approach is to tailor cell therapies specifically to each patient, essentially redefining the meaning of personalized medicine by making therapies for individuals in real time. This necessitates considering not just the cells and the targeting mechanisms, but the integrated and interrelated networks the cells form.

Sabry suggested that Once we start to reestablish normal immune regulation, some of the concerns we have now about having cell therapy either too powerful or not powerful enough will go away. The reason, he said, is that you will be using the regular, nuanced regulatory systems that exist within the immune system to regulate its power and amplitude.

Achieving the future these panelists envision for cell and gene therapies requires companies to take risks. Currently, big pharma does that largely by partnering with or acquiring smaller, innovative companies. In acquisition, though, there is another risk: that the smaller company will be subsumed and lose its innovative drive and, thus, the very reason it was acquired. Therefore its important, Sabry insisted, that innovative companies operate independently, like Genentech and Spark, which both were acquired by Roche.

Its a matter of balance, Mingozzi said. You cant do everything yourself.

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BIO 2020: Cell and Gene Therapies Will Dominate Medicine in 30 Years - BioSpace

Gauge Your Age: Epigenetics and the Future of Medicine – WhatIsEpigenetics.com

Why do some people stay healthy throughout their lives and others dont?

Whilewe all age, we dont all age in the same ways or at the same rate. Epigeneticmodifications are largely responsible for this phenomenon, with DNAmethylation being the most studied modification.

An EpigeneticClock is a sophisticated way of tracking our real age by measuring methylationor demethylation at particular DNA sites (Kanherkar, 2014). The uses forepigenetic clocks are manifold. The most obvious use comes as a diagnostictool, one that is already being offered by some companies as adirect-to-consumer test. The second is as an in vitro screening method, something to inspect the effects ofpharmaceuticals on cells in a petri dish. This lets researchers analyze subtlemolecular signs of aging, paving the way for the rapid discovery of potentialanti-aging therapeutics (Lujan, 2019).

In geriatric medicine, we are always struck by the difference between our patients chronological age and how old they appear physiologically.- Douglas, Kiel, HMS professor of medicine at Beth Israel

Accuratelyestimating biologicalage has tremendous value. This is because aging has a negative effect onevery aspect of our health. Its not a substitute for more specific tests, likefasting glucose levels, but paints a big picture. Like any other biomarker, itdoes not stand alone, but it is complementary to the growing ensemble of testsmodern medicine now has at its disposal. Epigenetic clocks made headlines withthe publication of a paper that found all-cause mortality could be predictedbased on methylation patterns in blood (Marioni et. al, 2015).

Inother words, the team found they could guess when someone was going to die fromany number of natural causes.

However,the title of MITs article, Want to knowwhen youre going to die? is sensationalistic and misleading. Even if ourinitial reading is not spectacular, we can take steps to change it. Someepigenetic modifications are well-entrenched, but not all are set in stone (Kanherkar, 2014).The sands of time flow downwards for us all, but the pace varies. In otherwords, what is not completely reversible can still be influenced by ourchoices, if not through lifestyle changes, then through future therapeuticsmeant to produce specific changes in the epigenome.

Whilethe usefulness of epigenetic clocks is not questioned, it is not clear why they work. Its also not obvious asto whether changes in DNA methylation are the cause or result of aging (Eckler,2019). Despite this fact, the literatureabout their current and potential applications continues to grow. A deeperunderstanding of exactly whats going on behind the scenes will help us developmore precise therapeutics. Steve Horvath, a pioneer in the field, envisions afuture where you can go to your doctor, get your clock checked, get aprescription, then return a few months later, significantly younger thanbefore.

Smoking,drinking, stress,chronic infection, and majordepression can all measurably accelerate the aging process as gauged by theepigenetic clock (Gao, 2016; Gassen, 2017; Horvath, 2015; Rosen, 2018; Han,2018). There is also an intrinsic rate ofaging, which appears to vary between individuals and populations. Certaingroups, like the Tsimane of Bolivia, age slowly compared to other ethnicities (Horvath,2016).

Direct-to-consumerkits are proliferating, like BioVivasTimeKeeper and Elysiums Index.Discouraging readings shouldnt be cause for panic or despair, but they canserve as wake up calls. A bad reading can be a cause for further investigation maybe its an issue with your telomeres or mitochondria. Maybe its a Klothodeficiency.

Whetherits prognostics, diagnostics, precision medicine, drug discovery, or basicresearch in gerontology, there is no doubt that the use of and uses forepigenetic clocks will continue to explode.

Referencesand Works Cited

Horvath S, et al. (2018). Epigenetic Clock Can Calculate Biological Age, Predict Lifespan. Medical News Today, MediLexicon International.

Ecker S, Beck S. (2019). The epigenetic clock: a molecular crystal ball for human aging?. Aging (Albany NY) 11 (2): 833-835.

Han, Laura KM, et al. (2018). Epigenetic aging in major depressive disorder. American Journal of Psychiatry 175. (8). 774-782.

Horvath S, Raj K. (2018) DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nature Reviews Genetics. 19.371-384.

Horvath S et al. (2016). An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease. Genome biology 17 (1) 171.

Horvath S, Levine AJ. HIV-1 infection accelerates age according to the epigenetic clock. J Infect Dis. 212(10):15631573.

Kanherkar RR, Bhatia-Dey N, Csoka AB. (2014). Epigenetics across the human lifespan. Front Cell Dev Biol 2. 49.

Lujan C, Tyler EJ, Ecker S, et al. (2019). A CellAge epigenetic clock for expedited discovery of anti-ageing compounds in vitro. bioRxiv.

Marioni RE, Shah S, McRae AF, et al. (2015). DNA methylation age of blood predicts all-cause mortality in later life. Genome Biol. 16(1): 25.

Weintraub, Karen. Want to Know When Youre Going to Die? MIT Technology Review, MIT Technology Review, 2 Apr. 2020. Web.

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Laughter is the best medicine – Bangkok Post

Educating children about the Covid-19 pandemic is a critical mission. The popular Kai Hua Ror (Laughter For Sale) comic magazine recently launched its special edition KnowCovid, which seeks to demystify for kids the disease that has so far infected more than 7 million people globally.

KnowCovid is currently available in Thai and English with translated versions coming soon. Photos Banlue Group

Using familiar cartoon characters and beautiful illustrations coupled with plenty of humour, KnowCovid is designed to show families how to protect themselves from the outbreak. Some 100,000 free print copies, as well as an e-booklet, are available now in Thai and English; and Myanmar, Cambodian and other versions are said to be on the way.

In the midst of this life-altering pandemic, many people remain concerned for their safety and finances. Adults at least can use their phones or social media as a medium to stay in touch with family, friends and colleagues and to exchange information on how to handle the situation wisely. But children and adolescents are suddenly trapped in confined spaces with their parents all day long. Stay-at-home orders mean they aren't allowed to go to school, visit a shopping mall or playground or spend time with friends. Even though many of the lockdown measures have been eased and many places reopened, some may not have a clue what's really going on. And this confusion could lead to the favourite question, "Why?", which sometimes can be difficult for the adult to explain.

With its goal to help children and families learn about Covid-19 through cartoon characters, KnowCovid was produced under a collaboration between Kai Hua Ror publisher Banlue Group, the World Health Organization Thailand, the United Nations, the Ministry of Social Development and Human Security, the Ministry of Public Health and parliament.

"We're glad to be a part of the project and also proud of our art in the form of a cartoon, which will help communicate and benefit society in times of crisis," said Pimpicha Utsahajit, Banlue Group executive director. "We sincerely hope to help protect people's lives and reduce the spread of infection, which will greatly reduce the burden on medical personnel. We believe that humour and good mental health are important for everyone at this time."

KnowCovid is currently available in Thai and English with translated versions coming soon. Photos Banlue Group

With its simple but effective content, KnowCovid shows readers how to reduce the risk of infection for themselves and their communities, from washing hands frequently and properly, coughing and sneezing safely, always wearing a mask, avoiding touching your mouth and nose, and learning about social distancing and how to stay a safe distance (1-2m) from others -- all told with humour and an easy-to-understand approach. Pimpicha said that there's a plan to release a translated version into different languages in neighbouring countries such as Laos, Cambodia and Myanmar to provide knowledge to foreign labourers regarding Covid-19 because the cartoon is a universal language and can cross any border. And Covid-19 is a crisis that the whole world faces.

The 56-page comic book features work by a team of well-known cartoonists with unique styles such as Wat, Fen or Tai, and his iconic fictional child character Pangpond, or Aor and the hilarious girl with bangs, Noo-Hin, or some of the new generation of cartoonists like Noi-na, Yung and Wirat who draw and use gags through these cartoon characters from the information submitted.

Pimpicha said that in the past few months there's been a lot of fake information about the disease that has circulated online, which could lead to weak protection or risky behaviour. One of the highlights of KnowCovid is the 12 false beliefs about Covid-19, such as drinking alcohol to prevent Covid-19, that thermometers can identify 100% of infected people, or that mosquitoes can transmit the coronavirus to humans.

"Apart from providing basic information about the virus, the cartoons take on sensitive topics and psychological issues, such as showing people how to reduce any stigma surrounding a coronavirus infection and how to be aware of domestic violence that has increased as a result of the pandemic lockdowns," said Pimpicha.

"It's quite an important issue that not that many people are talking about. Because lockdown measures may result in more violent factors, for example, family stress or loss of income, we believe this is useful information that should benefit any family. Because what we all need the most right now is a healthy family environment."

Pimpicha said the content provided in KnowCovid will still be relevant in years to come whether during a lockdown or not.

"As long as the medical profession has not yet found a cure or vaccine, and Covid-19 has not disappeared from the world, we believe that there are still many people on this planet who do not have the correct knowledge on Covid-19. So this information is always useful."

KnowCovid has now been released nationwide through village administration offices, village health volunteers, provincial halls, primary and secondary schools, public libraries, state-run hospitals and health centres. People can also download a copy at gocovid.issara.in.th, or request a copy by calling the 1300 hotline of the Ministry of Social Development and Human Security.

Pimpicha Utsahajit, executive director of Banlue Group. Apichit Jinakul

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Laughter is the best medicine - Bangkok Post

Bravo Fans Will Definitely Recognize This Familiar Face Coming to Married to Medicine Los Angeles – Bravo

Season 2 of Married to Medicine Los Angeles has already brought the fiercest drama, but things are about to get even more intense for this group of medical professionals and doctors' wives, as we can see in the above sneak peek of what's still to come this season.

There's so much more on the way for the Married to Medicine Los Angeles crew as they focus on giving their friendships and relationships some TLC, as well as explore what's next for their careers. Someone who's been doing a lot of all that this season is Shanique Drummond, who has continued to work on finding a balance between her family and her professional ambitions.

Shanique has expressed interest in breaking into luxury real estate this season, although her husband, Dr. Robert Drummond, isn't so sure if this is a good idea for their family. In an effort to prove her passion, Shanique has been doing all the research she can on the industry, and who better to give her some guidance than one of the top agents in the country, Million Dollar Listing Los Angeles' Josh Altman?

Josh will sit down with Shanique later on this season of Married to Medicine Los Angeles, and according to the above preview, he's going to deliver the hard truth about the cutthroat world of luxury real estate. "If you go on a listing appointment against me, you're gonna lose," Josh tells Shanique in the sneak peek.

However, the struggle to still be there for her family while also making her career dreams come true is very real for Shanique. "I don't want to not give 100 percent to my kids," she tearfully opens up in the clip to Dr. Imani Walker, who tells her friend, "But you have to stop beating yourself up."

Shanique isn't the only one who will be trying to find that balance between her personal and professional life as this season of Married to Medicine Los Angeles continues. Dr. Kendra Segura will have some difficult conversations with her husband, Dr. Hobart Leung, about her desire to return to work full-time after welcoming their first child.

When they're not navigating their friendships, the Married to Medicine Los Angeles ladies will be going through some challenges in their relationships. Dr. Britten Cole is still trying to figure out how to get her intimacy with her husband, Mack Major, back on track when their son likes to sleep in their bed. We'll also see Dr. Imani get emotional as she opens up about what's really been going on in her marriage to Phil Johnson.

Luckily, the Married to Medicine Los Angeles cast will always have each other to get through anything, even the most difficult times.

See what else is in store as Married to Medicine Los Angeles continues Sundays at 9/8c, above. Married to Medicine's Toya Bush-Harris and Quad Webb weigh in on the Season 2 drama, below.

Show Highlight

Toya Bush-Harris and Quad Webb Wonder Why Imani Walker Is So Angry at Jazmin Johnson

The Daily Dish is your source for all things Bravo, from behind-the-scenes scoop to breaking news, exclusive interviews, photos, original videos, and, oh, so much more. Subscribe to The Daily Dish podcast, join our Facebook group, and follow us on Instagramfor the latest news hot off the presses. Sign up to become a Bravo Insider and be the first to get exclusive extras.

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Bravo Fans Will Definitely Recognize This Familiar Face Coming to Married to Medicine Los Angeles - Bravo

MHPS, RCMP blended with new initiative – Medicine Hat News

By GILLIAN SLADE on June 9, 2020.

gslade@medicinehatnews.com

A new initiative to address crime will see Medicine Hat Police Service and the RCMP working together across traditional boundaries.

Andy McGrogan, chief MHPS, says the priority street crimes team is now expanding into a regional property crimes team after presenting a business case to the province showing the benefits of a new initiative.

The case study looked at nine specific cases where cross-jurisdictional issues had negatively impacted investigations.

McGrogan uses an example of someone in a rural area contacting MHPS after a robbery where a large amount of cash was stolen. The description of the suspect, believed to be addicted to drugs, helped MHPS to identify someone who was known to police. However the crime took place in a rural area covered by the RCMP.

McGrogan says by the time the suspect was apprehended the stolen cash was gone and could not be recovered.

If we would have had a regional team in place we would have been on that instantly and probably would have had that person and hopefully had some of that cash returned, said McGrogan.

Funding for three RCMP members to join the MHPS priority street crimes team has now been granted, said McGrogan. The province will also fund one of four MHPS officers on the team who were previously all funded by the city.

The RCMP is not able to immediately place people in the positions so members of MHPS are filling in until the RCMP appoints its own members within a matter of months, McGrogan said.

It gives us the ability to co-ordinate our activities all over southeastern Alberta in relation to prolific street crimes, said McGrogan.

The group has been operating for a couple of months already and has already seen significant success, said McGrogan.

Last week we got a stolen vehicle, a motorcycle its been good, he said.

A scheduled press conference in Medicine Hat with Doug Schweitzer, minister of justice and solicitor general, to make the announcement on Monday was cancelled with no rescheduled date provided.

The anticipated announcement by Schweitzer was also to include drug-related crime and addiction treatment supports. Schweitzers office was not immediately able on Monday to provide details on that initiative.

I am thankful the government listened We are going to show results, said McGrogan. As soon as they (the RCMP) bring their members in we will be standing our members down, said McGrogan.

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MHPS, RCMP blended with new initiative - Medicine Hat News

Parks and Rec: A different take on Parks and Recreation Month – Medicine Hat News

By Medicine Hat News Opinion on June 9, 2020.

While June signals the arrival of Parks and Recreation month, typically celebrated by engaging in community recreation opportunities, it goes without saying this year looks different. While it is always important to maintain proper safety procedures while recreating, there are extra measures to consider this year to keep individuals, families, and communities illness-free. Here are some ideas on how to keep active, healthy, and socially engaged throughout the summer while still maintaining the fight against COVID-19.

While public swimming areas will not be open this summer, there are alternate ways one can enjoy water-themed recreation. Floating or paddling down the South Saskatchewan river, or one of its tributaries, is a great way to enjoy the Medicine Hat areas gorgeous scenery. Remember to keep safe while on the water by checking weather and water conditions prior to heading out, and always wear a flotation device when in or near bodies of water.

Medicine Hat playgrounds will soon be open again, but it is encouraged to visit those closest to home, and re-think your visit if the park is busy. Disc golf courses at Gillwell, Leinweber, and Kiwanis Central Parks are great places to engage in friendly competition while keeping gatherings intimate.

The citys vast trail system provides the ability to get up close and personal with local natural areas. Medicine Hats unique grassland environment provides not only a gorgeous landscape, but is home to many plants and animals that thrive in prairie environments. The Citys environmental reserves, many of which have trail systems, are home to native grassland communities with significant ecological history, and value to the natural world. Enjoying and learning about these areas will in turn promote prairie conservation, helping maintain the ecosystems value as carbon reservoirs, and habitat for many animals and vegetation.

Whether in your backyard or a public space, remember that keeping connections alive between friends and nature will help the temporary two metre (six feet) separation seem smaller. Social distancing measures are simply another means of protection, not unlike wearing a helmet while biking, or a PFD while canoeing. Please visit http://www.medicinehat.ca to find more information on local public health updates, and remember to keep updated with changing Provincial guidelines and restrictions.

Keziah Lesko-Gosselin is a Parks Technician with the Parks and Recreation department, City of Medicine Hat.

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Parks and Rec: A different take on Parks and Recreation Month - Medicine Hat News

COVID-19 Traditional Chinese Medicine Treatment Market Review and Survey Report 2020 to 2026 – Cole of Duty

Global COVID-19 Traditional Chinese Medicine Treatment Market trends analysis report 2020 provides an in-depth analysis of the key players strategies, market growth, product demand, growth factors, regional outlook, global dynamics which includes drivers, challenges, and opportunities dominant in the industry. The Market report focus to provide extensive information on industry with market overview, key trends and business plans for COVID-19 Traditional Chinese Medicine Treatment market.

Click the link to get a free Sample Copy of the Report:

https://www.marketinsightsreports.com/reports/06092081458/global-covid-19-traditional-chinese-medicine-treatment-market-research-report-2020/inquiry?Mode=28

The report presents the market competitive landscape and a corresponding detailed analysis of the major vendor/key players in the market.Top Companiesin the Global COVID-19 Traditional Chinese Medicine Treatment Market:

Shijiazhuang Yiling Pharmaceutical

Tianjin Chase Sun Pharmaceutical

Beijing Juxiechang Pharmaceutical

Beijing Yiling Pharmaceutical

and Others.

It further provides the profile reviews of the leading participants, their overall market shares in the global market, business strategies they have adopted, and the latest developments in their respective business in a bid to enhance the decision-making capability of the readers.

This report segments the Global COVID-19 Traditional Chinese Medicine Treatment Market on the basis ofTypesare:

Lianhua Qingwen Capsule

Xuebijing Injection

Jinhua Qinggan Granule

On the basis ofApplication,the Global COVID-19 Traditional Chinese Medicine Treatment Market is segmented into:

Hospital

Special Clinic

Recovery Center

This study mainly helps understand which COVID-19 Traditional Chinese Medicine Treatment market segments or Region or Country they should focus in coming years to channelize their efforts and investments to maximize Growth and profitability. The report presents the market competitive landscape and a consistent in depth analysis of the major vendor/key players in the market.

GlobalCOVID-19 Traditional Chinese Medicine Treatmentfor a comprehensive understanding of market dynamicsmarkets are analyzed across key regions, namely North America (United States, Canada, Mexico), Europe (Germany, UK, France, Italy, Spain, Russia, Others), Asia-Pacific (China, Japan, South Korea, Australia, India, Southeast Asia, Others), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria, South Africa, Others), South America (Brazil, Argentina, Columbia, Chile, Others).Each of these regions will be analyzed based on market research results across major countries in these regions for a macro level understanding of the market.

Explore Full Report with Detailed TOC Here:

https://www.marketinsightsreports.com/reports/06092081458/global-covid-19-traditional-chinese-medicine-treatment-market-research-report-2020?Mode=28

Detailed overview of Market Changing market dynamics of the industry In-depth market segmentation by Type, Application etc Historical, current and projected market size in terms of volume and value Recent industry trends and developments Competitive landscape of COVID-19 Traditional Chinese Medicine Treatment Market Strategies of key players and product offerings Potential and niche segments/regions exhibiting promising growth

Research uses a bottom-up approach to assess the overall size of the market. Data from different industries and end-user industries and their applications across different product types are recorded and forecast during the forecast period. These segments and sub-segments are documented by industry experts and experts, as well as company representatives, and by analyzing data from these segments and sub-segments over the last few years, externally verified to gain market size.

We also offer customization on reports based on specific client requirement:

1-Free country level analysis for any 5 countries of your choice

2- Free Competitive analysis of any 5 key market players.

3- Free 40 analyst hours to cover any other data points.

MarketInsightsReportsprovides syndicated market research on industry verticals includingHealthcare, Information and Communication Technology (ICT), Technology and Media, Chemicals, Materials, Energy, Heavy Industry, etc.MarketInsightsReportsprovides global and regional market intelligence coverage, a 360-degree market view which includes statistical forecasts, competitive landscape, detailed segmentation, key trends, and strategic recommendations.

Contact Us:

Irfan Tamboli (Head of Sales) Market Insights Reports

Phone: + 1704 266 3234 | +91-750-707-8687

[emailprotected]|[emailprotected]

Note: All the reports that we list have been tracking the impact of COVID-19 the market. Both upstream and downstream of the entire supply chain has been accounted for while doing this. Also, where possible, we will provide an additional COVID-19 update supplement/report to the report in Q3, please check for with the sales team.

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COVID-19 Traditional Chinese Medicine Treatment Market Review and Survey Report 2020 to 2026 - Cole of Duty

Revolution Medicines Announces Dosing of First Patient in Phase 1b Combination Study of RMC-4630 and AMG 510 – GlobeNewswire

Study Evaluates Combination Treatment with Investigational SHP2 and KRASG12C Inhibitors in Patients with KRASG12C Mutant Solid Tumors

REDWOOD CITY, Calif., June 09, 2020 (GLOBE NEWSWIRE) -- Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage oncology company focused on developing targeted therapies to inhibit frontier cancer targets, today announced dosing of the first patient in a Phase 1b clinical trial evaluating the combination of RMC-4630, the companys investigational SHP2 inhibitor, and AMG 510, Amgens investigational KRASG12C inhibitor. The trial, which is being sponsored and conducted by Amgen with clinical supply of RMC-4630 provided by Revolution Medicines, is an open-label, dose-escalation and dose-expansion study evaluating the safety, tolerability, pharmacokinetics, and efficacy of the combination of RMC-4630 and AMG 510 in patients with advanced solid tumors harboring the KRASG12C mutation.

RMC-4630 is a potent and orally bioavailable small molecule that is designed to selectively inhibit the activity of SHP2, an upstream cellular protein that plays a central role in modulating cell survival and growth by transmitting signals from receptor tyrosine kinases to RAS. AMG 510 is a first-in-class investigational oral therapy designed to selectively and irreversibly target the KRASG12Cprotein, an oncogenic RAS mutant at the core of the RAS signaling cascade.

Preclinical and clinical research has shown that cancers caused by RAS pathway mutations exhibit oncogene addiction, in which tumor cells become highly dependent on signaling through the RAS pathway to survive. Suppressing KRASG12C activity, either directly with AMG 510 or indirectly by inhibiting SHP2 with RMC-4630, has shown anti-tumor activity against non-small cell lung tumors harboring KRASG12C in early clinical trials. In addition, adaptive resistance to inhibition of RAS signaling is common. SHP2 is an upstream RAS pathway node that often plays a key role in adaptive resistance, and inhibiting SHP2 with RMC-4630 has been shown preclinically to suppress adaptive resistance to KRASG12C inhibitors.

Our strategy is to advance a broad clinical program to assess the therapeutic potential of RMC-4630 in both monotherapy and multiple combination treatment regimens. With our recent demonstration of encouraging monotherapy activity for RMC-4630 against KRASG12C lung cancers, it is compelling to pair this investigational drug with KRASG12C inhibitors such as AMG 510, said Mark A. Goldsmith, M.D., Ph.D., chief executive officer and chairman of Revolution Medicines. This collaborative trial sponsored by Amgen, a leader in the field, will help test our hypothesis that RMC-4630 may be useful as the backbone of targeted therapy combinations for the treatment of various RAS-dependent tumors.

RMC-4630 and AMG 510 have each demonstrated activity in early-stage clinical trials in patients with KRASG12C tumors, stated Steve Kelsey, M.D., president, research and development at Revolution Medicines. Initiation of this trial is an important step in the evaluation of this combination and its potential to treat RAS-dependent cancers by simultaneously inhibiting the activity of different oncogenic targets within the RAS signaling cascade.

About RMC-4630 and Sanofi Collaboration

RMC-4630 is currently being evaluated in a Phase 1 monotherapy clinical trial (RMC-4630-01) for a range of tumor types featuring specific, molecularly-defined oncogenic mutations, a Phase 1b/2 study (RMC-4630-02) in combination with cobimetinib in patients with relapsed/refractory solid tumors displaying specific genomic mutations, and in the recently initiated Amgen-sponsored Phase 1b study in combination with AMG 510 in patients with advanced solid tumors harboring the KRASG12C mutation.

The SHP2 inhibitor program, including RMC-4630, is the focus of an exclusive global research, development and commercialization agreement with Sanofi.

About Revolution Medicines, Inc.

Revolution Medicines is a clinical-stage oncology company focused on developing novel targeted therapies to inhibit elusive high-value frontier cancer targets within notorious growth and survival pathways, with particular emphasis on RAS and mTOR signaling pathways. The company possesses sophisticated structure-based drug discovery capabilities built upon deep chemical biology and cancer pharmacology know-how and innovative, proprietary technologies that enable the creation of small molecules tailored to unconventional binding sites.

The companys pipeline includes RMC-4630, a clinical-stage drug candidate that is designed to selectively inhibit the activity of SHP2. Additionally, the company is developing a broad portfolio of inhibitors of other key frontier oncology targets within the notorious RAS pathway and the related mTOR signaling cascade. These include inhibitors of multiple mutant RAS proteins and SOS1, as well as RMC-5552, a development candidate within the companys 4EBP1/mTORC1 program currently in IND-enabling studies.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered "forward-looking statements," including without limitation statements regarding Revolution Medicines development plans and timelines, including without limitation the planned clinical study of RMC-4630 in combination with an investigational KRASG12C inhibitor, AMG 510, the potential anti-tumor mechanisms for SHP2 inhibitors, Revolution Medicines goal of assessing the therapeutic potential of RMC-4630 as monotherapy or in combination treatment regimens to treat RAS pathway cancer, and the potential benefits of, and markets for, Revolution Medicines product candidates. Forward-looking statements are typically, but not always, identified by the use of words such as "may," "will," "would," "believe," "intend," "plan," "anticipate," "estimate," "expect," and other similar terminology indicating future results. Such forward-looking statements are subject to substantial risks and uncertainties that could cause our development programs, future results, performance or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include without limitation risks and uncertainties inherent in the drug development process, including Revolution Medicines programs early stage of development, the process of designing and conducting preclinical and clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Revolution Medicines ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of Revolution Medicines capital resouces to fund operations, reliance on third parties for manufacturing and development efforts, changes in the competitive landscape and the effects on our business of the worldwide COVID-19 pandemic. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Revolution Medicines in general, see Revolution Medicines Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on May 14, 2020, and its future periodic reports to be filed with the Securities and Exchange Commission. Except as required by law, Revolution Medicines undertakes no obligation to update any forward-looking statements to reflect new information, events or circumstances, or to reflect the occurrence of unanticipated events.

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Revolution Medicines Announces Dosing of First Patient in Phase 1b Combination Study of RMC-4630 and AMG 510 - GlobeNewswire

‘Our China boycott medicine is hitting the right spot’: Sonam Wangchuk reacts to Amul ad, Google Play Store report – Livemint

Sonam Wangchuk is happy with how his boycott China call has led to an action-oriented disruption of Chinese services in India. Reacting to the news stories about Amul account suspension, Google Play Store removal of anti-China apps and a Global Times report on Indian consumers, Wangchuck said, " This is a good news, our medicine is hitting the right spots."

"The people's call for boycott of Chinese products, uninstallation of Chinese apps is forcing China to coerce Google and Twitter to take down the anti-China narrative," Wangchuk said in a brief Youtube video uploaded Monday.

"The only takeaway from the recent China-related controversies are that people's call for action is having a far reaching impact, please continue on this path," said the man who inspired Aamir Khan's character in Bollywood blockbuster 3 idiots.

Wangchuk also pointed out a report of China's state-run publication, Global Times titled, "Indians can hardly resist buying Chinese quality goods: analysts," adding that the boycott call is impacting China, otherwise Global Times would not have commented on this.

Ladakh-based innovator and educationist Sonam Wangchuk had appealed to Indians to boycott Chinese products in the backdrop of the recent standoff between Indian and Chinese forces along the Line of Actual Control (LAC) in that region.

Wangchuk's call of "give up all Chinese software in a week, all Chinese hardware in a year," has resonated with millions of Indians in the face of Chinese aggression in the Eastern Ladakh reason.

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'Our China boycott medicine is hitting the right spot': Sonam Wangchuk reacts to Amul ad, Google Play Store report - Livemint

From obesity to allergies, outdoor play is the best medicine for children – The Sector

What if there was a simple, inexpensive and fun way to address some of the major challenges facing humanity today. What if it could help improve childrens health, development and well-being?

Imagine a solution that could stem the current epidemics of obesity, anxiety and depression affecting children and youth today. Imagine that this solution could also promote brain health, creativity and academic achievement and prepare our children for the rapidly-changing work force.

Along the way it could reduce incidence of allergies, asthma and other immunity challenges and improve eye health. It could foster a culture of environmental stewardship and sustainability and help build the health of cities promoting neighbourliness and feelings of community connection.

Imagine that this intervention could also help countries meet their targets for many of the United Nations Sustainable Development Goals, such as the goals of Good Health and Well-being, Inclusive and Equitable Quality Education, Decent Work and Economic Growth and Climate Action.

This isnt an expensive intervention, or one that parents have to force their children to do like homework or eating their vegetables. Rather than dreading it, children report being at their happiest when doing it and they seek ways to keep at it for as long as possible.

What is this fix-all simple solution? Playing outside.

Many of us have fond memories of childhoods spent outside, hanging out with friends in our neighbourhoods, parks and wild places, making up the rules as we went along, with minimal (if any) adult supervision.

We need only reflect on our own play memories to realize how valuable these experiences can be and how they can shape our lifelong health and development. The research is now catching up to our intuitions, recognizing the vast and diverse benefits of outdoor play.

Playing outside is not the same as playing inside. There are unique benefits of being in the outdoors, particularly in nature, that dont come as readily indoors. When children are allowed to play the way they want to play in stimulating environments, they move more, sit less and play longer.

They get their hands in the dirt and are exposed to microbes that help them build their immunity. They make their own goals and figure out the steps to attain those goals, helping them build executive function skills. They learn, build resilience and develop their social skills, learn how to manage risks and keep themselves safe. Their eyes get the exercise they need to help combat short-sightedness.

We are rediscovering the magic of outdoor play. Governments see it as a way of getting kids active and averting the obesity crisis. Schools and early childhood centres see it as a way of promoting academic and socio-emotional learning. Corporations see it as a way of preparing children for the jobs of the future that will focus on creativity, empathy and connection with others. Children just see it as a way of having fun and feeling free!

There are three key ingredients to supporting outdoor play: time, space and freedom.

Kids need time to be able to play outside. In schools, that means recess policies that get kids outside every day, finding opportunities to use the outdoors for learning and limiting homework. At home, that means laying aside screens and limiting scheduled structured activities.

Kids also need high quality outdoor spaces to play in. That doesnt necessarily mean expensive playground equipment. It means spaces where all children feel welcome, regardless of their abilities and backgrounds, that they can make their own and that also have loose parts (for example sticks, stones, water and cardboard boxes) they can use and let their imagination shape the play.

In cities, that means being prepared for and allowing play to happen everywhere, not just parks and playgrounds. We need to design inclusive and child-friendly cities where kids feel welcome everywhere and can easily access nature.

Finally, freedom: the biggest barrier to childrens ability to play the way they want to play is adults. We need to let go of our excessive fears of injuries and kidnapping and realize that the benefits of kids getting out to play far outweigh the risks. My lab developed a risk reframing tool for parents and caregivers to help them on this journey.

Helping support childrens outdoor play can be as simple as opening the front door. It doesnt have to be complicated or expensive. If we all do our bit, we can help bring back this crucial activity that should be part of all childrens daily lives, regardless of age, cultural background, gender or ability.

There are lots of tools to help you get started, whether youre a parent, caregiver, educator, city planner or a neighbour.

I would encourage you to consider one simple and attainable thing you are going to do today to help get the child or children in your life get out to play.

Mariana Brussoni, Associate Professor of Pediatrics and Population and Public Health, University of British Columbia

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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From obesity to allergies, outdoor play is the best medicine for children - The Sector

Plant drug factories: GMOs and gene editing are poised to transform medicine. Heres how. – Potato News Today

Plant biotechnology is poised to drastically improve how we consume medication. Using the modern tools of genetic engineering, researchers are developing plant-based drugs that are cheaper, easier to take and even more effective than their existing counterparts. Tautvydas Shuipys reports for the Genetic Literacy Project.

Shuipys writes that while many diseases can be treated with orally administered medications, other drugs such asbiologics or biopharmaceuticals, medicines derived from living organisms, must be delivered using other strategies. Conventional drugs like aspirin are chemically synthesized and can survive digestion, whereas biologics like hormones, antibodies, enzymes, and other complex organic molecules are vulnerable to degradation by enzymes in our saliva and stomach, as well as environmental conditions like pH and heat.

This makes biologics in pill form unlikely to survive the harsh environment of the digestive tract.

There are more than 200 FDA-approved biologic drugs. While less than two percent of people in the US rely on biologics,they make up 40 percent of prescription drug spending.

Identifying a better way to produce and administer biologics has the potential to ease the physical and financial burden associated with these drugs. For this reason, researchers are turning to the original inspiration for medications: plants.

Evidence for plant use in medicine dates back all the way to thePalaeolithic Age. But instead of trying to find new plants that produce medically relevant compounds, researchers are turning to genetic engineering to express the same biologics currently grown in bacterial, yeast, or mammalian cells.

Producing biologics in plants has anumber of advantages. Plants are potentially less costly to grow, requiring inexpensive fertilizers instead of specialized cell culture growth media. Plants can also be grown in fields or greenhouses without requiring sterile environments, meaning that scaling up production would just require more growing area as opposed to additional expensive bioreactors. An added benefit is that plants do not serve as hosts for human pathogens, reducing the likelihood of harm from contaminants that bacterial or mammalian cells may house.

In addition to medication production, companies are also looking to utilize some of the benefits of plant-based production for vaccines. Medicago, a Canada-based company seeking approval for theirplant-produced flu vaccine, has announced that using this same technology, they have produced acandidate vaccine for COVID-19in twenty days.

By growing the protein for the vaccine in plants, as opposed tousing eggs to propagate the virus, Medicago has been able to cut the cost and time required to produce a new vaccine. The vaccine is now awaiting clinical testing and FDA approval.

Read Tautvydas Shuipys full article on this topic on the Genetic Literacy Project website here.

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Plant drug factories: GMOs and gene editing are poised to transform medicine. Heres how. - Potato News Today

University of Rochester Medicine to cut ribbon on Olean oncology infusion site June 19 – Olean Times Herald

OLEAN Officials hope to cut the ribbon at a new $1.7 million chemotherapy infusion center next month, and everyones invited.

The oncology outpatient clinic at 1504 W. State St., previously the home of Family Video, is being developed by Wellsville-based Jones Memorial Hospital part of the University of Rochester Medicine network. UR Medicine officials reported that the first patients will be seen Monday at the facility, and a virtual ribbon-cutting will be held June 19.

There are a limited number of options for celebrating an event like this, said Brenda Szabo, vice president of specialty services at Jones Memorial. We can only have 10 people attend the event in person, but wanted to make sure that everyone who is interested can see everything the new center has to offer so we will be broadcasting it as a Facebook Live event and then posting that video on our website.

Local oncologist Dr. Neeta Soni, who joined the UR Medicines Wilmot Cancer Institute team last year, will continue to provide consultation and treatment to oncology patients at The Infusion Center at Jones Memorial in Wellsville, as well as the new office in Olean.

Officials reported this winter that the network currently treats between 1,500 and 2,000 patients a year through Southern Tier Cancer Care on East Delaware Avenue. That practice opened in 2003. The new site will replace that facility, and almost double the number of infusion bays to cut wait times for patients.

We wanted to keep access to these services close to home and convenient for these communities, Szabo said. Cancer patients who were driving to larger metropolitan areas like Buffalo and Rochester, can avoid that drive and receive quality cancer care with Dr. Soni, an experienced and knowledgeable oncologist.

The project was given contingent approval by the state Department of Health on Dec. 3, with an assigned start date of Jan. 31. The original completion date was May 31, as construction efforts were well underway before the COVID-19 pandemic gripped the nation.

According to the filing with the DOH, the center will serve as a centralized point for oncology infusions chemotherapy for the hundreds of area patients.

The project also aims to help increase income for the hospital as officials attempt to leave the Vital Access Provider Program. VAP, a state program to help financially distressed healthcare entities, helps fund operational costs for turnaround initiatives with a focus on financial viability, meeting service needs, improving care quality and increasing health equity for populations at risk.

The filing states the project is expected to add a minimum of $800,000 of operating income to the hospitals annual budget. The move will also take the operation from a for-profit enterprise to a nonprofit one.

Jones Memorial joined UR Medicine in late 2015.

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University of Rochester Medicine to cut ribbon on Olean oncology infusion site June 19 - Olean Times Herald

TTU School of Veterinary Medicine receives $1.4 Million CPRIT recruitment grant – KLBK | KAMC | EverythingLubbock.com

by: News Release & Posted By Staff | newsweb@everythinglubbock.com

Artist rendering of the Texas Tech University School of Veterinary Medicine in Amarillo.(Photo provided by Texas Tech University)

LUBBOCK, Texas (NEWS RELEASE) The following is a news release from Texas Tech University:

TheCancer Prevention and Research Institute of Texas(CPRIT) has awarded a transformative grant to theTexas Tech University School of Veterinary Medicine in Amarillodesigned to bring to the schools growing faculty one of the worlds leading cellular and molecular biologists.

The $1.4 million grant will allow Klementina Fon Tacer, a postdoctoral researcher at St. Jude Childrens Research Hospital in Memphis, Tennessee, since 2016, to join the veterinary school faculty. Supported by this award, Fon Tracer will investigate the novel mechanisms that protect mammalian germ cells against stress and how those mechanisms are co-opted in cancer, with the ultimate goal of advancing cancer treatment and fertility preservation of childhood cancer survivors.

The hope is Fon Tacers research will establish a strong foundation for a comparative oncology research center in the School of Veterinary Medicine.

What we do and why we do it is simple. We are here to benefit Texas and Texans, saidGuy Loneragan, dean of the School of Veterinary Medicine. Dr. Fon Tacer is going to change lives for generations to come. When we first had the chance to meet her, it was clear. Her research is transformative and will impact countless Texans in the years ahead. I am so thankful to the CPRIT Oversight Committee for awarding Texas Tech this recruitment award to make it possible to bring Dr. Fon Tacer to Texas and to the School of Veterinary Medicine. Her work in comparative oncology will save lives.

The Recruitment of First-Time, Tenure-Track Faculty Members Award, one of seven awarded by CPRIT this week and part of 13 academic research recruitment and product development awards totaling $56 million, is the first CPRIT grant awarded to the School of Veterinary Medicine, which is scheduled to open its doors to students for the first time in the fall of 2021.

Fon Tacer earned her Doctor of Veterinary Medicine (DVM) and Doctor of Philosophy in Biochemistry and Molecular Biology from the University of Ljubljana in Slovenia. She also holds a Master of Science in Biochemistry and Molecular Biology from the University of Ljubljana.

Fon Tacer is not new to Texas, having served as a postdoctoral researcher and Fulbright Fellow at the University of Texas Southwestern Medical Center in Dallas from 2006-2008. From there, she returned to the University of Ljubljana as a postdoctoral researcher and later as an adjunct assistant professor on the veterinary faculty at the University of Ljubljana until 2012.

Among her research interests at St. Jude Childrens Research Hospital are melanoma antigen genes (MAGE), very common cancer immunotherapy targets and their role in cancer reproduction, metabolism and stress response.

We are very excited to have support from CPRIT for building the faculty of our new School of Veterinary Medicine, saidJoseph Heppert, vice president of theOffice of Research & Innovation. One-health research themes developed by faculty like Dr. Tacer will have enormous benefits for both human and animal health. TheTexas Tech University Systemhas strong potential for collaboration in one-health research across the Texas Tech andTexas Tech University Health Science Centercampuses, and we are extremely proud to be adding new faculty who will capitalize on these opportunities.

Thanks to the generosity of Amarillo and communities across Texas, and the commitment of legislators from around the state, the Texas Tech University School of Veterinary Medicine in Amarillo, established in 2018, is working to enroll its first class in the fall of 2021, pending approval by the AVMA Council on Education.

The School of Veterinary Medicine will recruit and select students with a passion to practice and succeed in rural and regional communities. Its curriculum is focused on the competencies and skills necessary for success in practices that support these communities. Texas Techs innovative and cost-efficient model partners with the wider community of veterinary practices across the state to provide clinical, real-world experiential learning.

In June 2019,Gov. Greg Abbott signed into law the biennial state budget, which appropriated $17.35 million for the School of Veterinary Medicine in Amarillothat will go toward operational needs in order to get the school up and running. The appropriation included language directing Texas Tech to move forward in establishing the school.

To date, CPRIT has awarded almost $2.5 billion in grants to Texas research institutions and organizations through its academic research, prevention and product development research programs. CPRIT has recruited 181 distinguished researchers, supported the establishment, expansion or relocation of 36 companies to Texas and generated more than $3 billion in additional public and private investment. CPRIT funding has advanced scientific and clinical knowledge and provided 5.7 million life-saving cancer prevention and early detection services, reaching Texans from all 254 counties. In November 2019, voters in Texas approved a constitutional amendment authorizing an additional $3 billion in bonds for cancer research and prevention.

(News release from Texas Tech University)

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TTU School of Veterinary Medicine receives $1.4 Million CPRIT recruitment grant - KLBK | KAMC | EverythingLubbock.com

Office of Faculty Affairs announces faculty promotion and tenure – The South End

The Wayne State University School of Medicines Office of Faculty Affairs and Professional Development announced promotions and tenure status for more than 75 faculty members.

This year we had a record number of School of Medicine faculty members who received the well-deserved recognition of being promoted to a higher academic rank. Among these were faculty members who distinguished themselves as scientists, educators, renowned clinicians, dedicated citizens and community leaders, said Vice Dean of Faculty Affairs Basim Dubaybo, M.D. It is gratifying but not surprising that even during a debilitating pandemic, our university continues to fulfill its academic and service missions without hesitation. This reflects our commitment to our students and our community, where a large number of physicians who participate in our academic mission have received the recognition and promotion they have earned.

Five faculty were granted tenure, including Associate Professor of Oncology Asfar Azmi, Ph.D.; Associate Professor of Ophthalmology, Visual and Anatomical Sciences Elizabeth Berger, Ph.D.; Associate Professor of Physiology Robert Wessells, Ph.D.; Associate Professor of Obstetrics and Gynecology Nerissa Viola, Ph.D.; and Associate Professor of Obstetrics and Gynecology Nardhy Gomez-Lopez, Ph.D.

I am honored to receive the promotion of tenure at the Wayne State University School of Medicine. I am grateful to be part of the Perinatology Research Branch, whose translational research is dedicated to improving the lives of mothers and children, Dr. Gomez-Lopez said. This accomplishment was largely due to the successful collaborations that I have established in the intellectually-stimulating environment within the Perinatology Research Branch. I am particularly grateful to (PRB Chief and Professor of Obstetrics and Gynecology) Dr. Roberto Romero and (Professor and Chair of Obstetrics and Gynecology) Dr. Chaur-Dong Hsu for their continuous support of women in science.

A complete list of promoted faculty is now available at https://facaffairs.med.wayne.edu/ptawards

A formal celebration will be held at a later date.

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Office of Faculty Affairs announces faculty promotion and tenure - The South End