Northwestern Medicine scientists develop novel method to track HIV infection – News-Medical.net

August 18, 2017

Northwestern Medicine scientists have developed a novel method of tracking HIV infection, allowing the behavior of individual virions — infectious particles — to be connected to infectivity.

The findings could help lead to the development of novel therapies for HIV prevention and treatment by providing a deeper understanding of the mechanisms of HIV’s lifecycle.

The paper was published August 7 in Proceedings of the National Academy of Sciences.

It has become routine to visualize the movement and progression of individual virions in cells, but the relevance of these observations was previously unclear, as many virions are defective or do not progress to make further copies of themselves.

“This approach — and the ability to say ‘that virion infected that cell’ — will help bring clarity to the field,” said principal investigator Thomas Hope, a professor of cell and molecular biology at Northwestern University Feinberg School of Medicine. “It allows us to understand what the virus really needs to do to infect a cell. It gives us new details, like where in the cell it happens and the timing of specific events. The more we know about the virus, the better our chances are to stop it.”

During the course of infection, HIV fuses onto a target immune cell and delivers its capsid — a cone that holds the genetic material of the virus — into the cell’s cytoplasm. From there, the capsid disassembles through a process called “uncoating,” which is crucial to the synthesis of viral DNA from its RNA genome and the hijacking of the cell’s functions.

But the specific details of uncoating have been controversial, with two groups of thought. One believed that uncoating takes place late at pores, allowing factors to enter the nucleus. A second camp showed data suggesting that uncoating takes place early and in the cytoplasm.

In part, the uncertainty persisted because previous methods in HIV research have been unable to distinguish between viral particles that actually lead to infection of the cell, and those that are irrelevant.

In the current study, the team of scientists used a novel live-cell fluorescent imaging system that allowed them for the first time to identify individual particles associated with infection.

In this case, they utilized the approach to monitor how the HIV capsid uncoats in the cell at the individual particle level. They demonstrated that uncoating leading to infection occurs early in the cytoplasm, around 30 minutes after cell fusion.

The finding is just one example of novel discoveries about HIV that might now be possible with the imaging system.

“Being able to connect infectivity of individual particles and how they behave in the cell to infection — which is what we really care about — is going to have a big impact on the field,” Hope said. “The system can now be used to resolve other controversies in HIV biology and to determine which potential targets for drug development are most relevant.”

The study has implications in the wider field of virology research as well.

“Theoretically, you could apply this technique to the study of any fluorescently-tagged virus,” explained first author Joo Mamede, a post-doctoral fellow in Hope’s laboratory.

In future projects, Hope’s research team plans to continue to leverage the method to study infection in later stages of the HIV lifecycle.

“We want to understand all the details, from when the virus fuses, to the point where it integrates and starts to make new viruses, to the last phase,” explained Hope, also a professor of Obstetrics and Gynecology and of the McCormick School of Engineering. “We need to understand what’s going on, so we can find the Achilles’ heel of the virus and use it as a drug target.”

Read more:

Northwestern Medicine scientists develop novel method to track HIV infection – News-Medical.net

‘Insecure’ Actor Jay Ellis Talks New Web Series ‘Hard Medicine’ And Lawrence Hive – Essence.com

The actor has jumped into the producers chair for a new workplace comedy.

Jay Ellis is a pretty busy guy. Outside of hit series Insecure, the actor and producer is working on a number of projects, one of which is the new web series Hard Medicine.

RELATED: Jay Ellis Says Fans Well Get To See Lawrence’s “World Open Up” In Season Two Of ‘Insecure’

The series, produced by Ellis and his producing partner Paula Bryant-Ellis, is a workplace comedy in the vein of The Office. The first two episodes of the series are available on Ellis Facebook page and the Urban Movie Channel (UMC) has picked up the remainder of the eight-episode first season.

While similar comedies have had a few people of color in its cast, the star of Hard Medicine is Dr. Harriet Moore, played by Nicole Slaughter, a black woman in charge of a low-income health clinic.

RELATED: Jay Ellis UsedIssa Rae’s Instagram To Confess His Love For ‘Chewing Gum’ Actress Michaela Coel

“We always felt that for us, it’s The Office meets Scrubs, but with people of color Ellis told ESSENCE. People of color have worked in medicine just like everybody else. We can use this type of filmmaking in that type of way to tell a story and to tell a comedy just like anyone else can.

The show is the brainchild of Melissa Eno Effa, who plays the acerbic Clarice. She [Melissa] came up with this concept and I was like ‘I want to shoot it like this.’ This is the kind of show I grew up on and love. And, these clinics in black neighborhoods have always been faced with being shut down, but what still service the community.

Soon after teaming up with Melissa, UMC called and offered to bring the show over to their network, becoming another in a list of web hits to become television successes.

The barrier to entry has gotten torn down, Ellis said. “What were finding and what all these networks are finding and different digital services are finding is that the web is a great testing ground. You can put things out there, tighten them up and build an audience around them.

And, nowhere is that more evident than Ellis hit series Insecure, created by and starring Issa Rae. The HBO show was inspired by Raes own successful web series, Awkward Black Girl, which saw Rae awkwardly navigating adulthood and dating.

Insecure is now in its second season and has been renewed for a third, which means the new and dedicated Lawrence Hive will get to see their boy once again.

I never expected that, Ellis adds, when asked about his new fans. You never expect it.

Reflecting on the insanity of Insecure’sseason one finale, Ellis said, I was on a thirteen hour flight, so I actually missed the finale. When I landed I turned on my phone and my battery died before I could even get home because my phone was ringing so much. So many text messages came through and I kept getting updates on Twitter and Instagram, it was insane.

You know, you never think a hive is going to happen, its something you cant control.

Ellis added, I see Lawrence and I see a lot of my friends. I see a lot of things I’ve done and have gone through. There are so many things hes going through that are relatable and I think that is something that is really cool. To see so many black men be able to see representation of themselves on television. That to me is what the hive is all about.”

You can watch episodes of Ellis’ new series, Hard Medicine, every Wednesday on UMC. And, if fans use the code HMonUMC17theycan get 60 days for free.

Read more:

‘Insecure’ Actor Jay Ellis Talks New Web Series ‘Hard Medicine’ And Lawrence Hive – Essence.com

Authors believe gender gap in veterinary medicine is fixable – Purdue Exponent

Women make up 55 percent of active veterinarians and nearly 80 percent of the students in veterinary medicine. Despite this, women only make up 25 percent of leadership roles, and average salaries in the profession have dropped.

The book Leaders of the Pack: Women and the Future of Veterinary Medicine, published by Purdue University Press, was written by Julie Kumble M.Ed. and the late Dr. Donald Smith, dean emeritus of Cornell University’s College of Veterinary Medicine, to address the gender gap between men and women in leadership.

Kumble, a researcher and writer whose career focused on empowering women, said that the gender gap isnt unique to veterinary medicine but can be found in every other field.

I just want to stress that every profession has a gender gap at the top of every single profession, Kumble said. The people at the top echelons of nursing, the CEOs and CFOs, those tend to be more men. Look at our Congress, its 20 percent women. If you look at who the partners are in law firms, only 20 percent are women, so its across the board. Veterinary medicine isnt unique.

According to Kumble, the gender gap is the result of many factors and there isnt one gleaming answer. One factor is that men were traditionally in the profession longer than women and own specialty practices like orthopedics or dentistry; these specialty practices pay higher salaries. Kumble encourages women to own their own practices.

Another factor is the linear trajectory of a career that doesnt accommodate women with children.

Women are the ones bearing children and raising children so how are we going to build into our system ways for them to get back to work when theyre ready and not miss out on salary and not miss out on promotions, Kumble said.

Kumble cited the Scandinavian countries as a source for solutions, which include policies on family leave or requiring minimum percentages of women on directory boards.

In the book, she gives advice on how women can close the gender gap. One thing she would say to a new student studying veterinary medicine is to be open-minded to the vast opportunities in the profession, from research to the government.

The second is to find mentors during all stages of your career who can offer advice and shine light on your path, (and) then to do the same for others, Kumble said.

Willie Reed, the Purdue dean of veterinary medicine, acknowledges the gender gap and hopes to be a mentor for his students.

Encouraging women to consider leadership positions and providing training for them is something we have fostered here in the college, Reed said.

Reed nominates women for a training program through the Association of American Veterinary Medical Colleges, and the senior administration in Purdues college has more women than men, unlike most colleges.

One of the women who went through the program is Doctor of Veterinary Medicine Ann Weil, a clinical professor of anesthesiology.

I think my dean has done a lot to help me personally in terms of improving my leadership skills, Weil said. The AAVMC sponsors leadership training, and I had the privilege of being asked to participate in the program. You learn media training, conflict resolution, team building, and listening skills. Its a pretty intense program.

Reed believes leadership development is important not just for the faculty but also the students in his college, who are predominately women.

Leadership is something that is needed and is expected, Reed said. Its like many things, you have to study leadership and be trained and thats part of what were doing here in the curriculum of veterinary medicine.


Authors believe gender gap in veterinary medicine is fixable – Purdue Exponent

Hervert a resident in internal medicine at St. Bernards in Arkansas – Kearney Hub

JONESBORO, Ark. Dr. Mitchell Hervert has been selected to be a part of this years class of physicians in an internal medicine residency program at St. Bernards Medical Center in Jonesboro.

He was born and grew up in Ord, Neb. Hervert earned his Doctor of Osteopathic Medicine degree from Kansas City University of Osteopathic Medicine in Kansas City, Mo., and earned a bachelors degree in biology from Hastings College in Hastings, Neb.

Hervert is the son of Clark and Laurie Hervert of Ord and the grandson of Shirley Wolfe of Kearney, Neb.

Hervert is one of five recent medical school graduates selected for advanced training in the field of internal medicine at St. Bernards. The physicians began duties on July 1 and are taking part in intensive training through observation and lecture, working under the mentorship of other physicians as they provide inpatient care in the hospital setting as well as follow-up care through a residents clinic.

Read the original:

Hervert a resident in internal medicine at St. Bernards in Arkansas – Kearney Hub

Women doctors set to take center stage at World Extreme Medicine Conference – News-Medical.net

August 17, 2017

At the World Extreme Medicine Conference, (http://www.extrememedicineexpo.com/ ) which will take place at Dynamic Earth, Edinburgh, EH8 8AS from Saturday November 25 to Monday November 27 2017, women doctors, medics and endurance athletes will take center stage and inspire fellow extreme medicine practitioners, clinical doctors and the next generation of the medical community.

The Coxless Crew Led By Laura Penhaul Aboard Doris

The conference will bring together specialist medics from a wide range of disciplines, typically outside of a conventional hospital environment including some of the worlds most respected names in humanitarian, wilderness and pre-hospital medicine.

Speakers include:

Rachel Anderson, an Emergency Medicine Consultant from Edinburgh who has worked in expedition environments at Union Glacier in Antarctica and Mount Everest in Nepal, where she worked for Everest ER for two seasons as a base camp medic. She has previously completed the Diploma in Mountain Medicine (DIMM) and was lead lecturer on a wilderness medical expedition to Aconcagua in 2013 and the Everest Base Camp trek for Expedition Medicine in 2014 and 2017.

Brighton-based Kate Yarrow, the chairman and founder of Doctors For Nepal, a UK charity which improves healthcare in rural Nepal by sponsoring the training of doctors and nurses from impoverished backgrounds in Nepal. She founded DFN in 2008, following two missions with Mdecins sans Frontiers (MSF). Her work in Nepal with MSF and Doctors For Nepal ignited a keen interest in healthcare in the Nepalese mountains, which led her to write and present Namaste: A Himalayan Journey a Hollywood award-winning documentary about healthcare in the Himalayas.

Kate, who is also the clinical lead in west Kent for Sexual and Reproductive Healthcare, is passionate about womens health, both in the UK and in the developing world. She is keen to emphasise and teach the importance of addressing and maintaining womens health in complex and challenging environments.

Laura Penhaul, a physiotherapist from Cornwall who works at the John Radcliffe Hospital in Oxford, and has worked with the GB ski team, Paralympic ski and Paralympic summer sports teams.

She specializes in sports injuries tending to the ripped muscles of Ironman athletes and ultra-marathon runners and is also an expert on spinal cord injuries. Laura is currently working as the Performance Manager for endurance cyclist Mark Beaumont as he attempts to cycle around the world in 80 days an unprecedented feat.

Laura also led the all-female Coxless Crew in a record-breaking row across the Pacific Ocean on a 257-day journey from the United States to Australia in which they rowed 24 hours a day in two-hour shifts.

Mark Hannaford, founder of conference organizers World Extreme Medicine (http://expeditionmedicine.co.uk/ ) said:

Were fortunate to have such an inspirational group of women at the World Extreme Medicine Conference this year, and hope that they can help to persuade the next generation of female medics and doctors that there is a broad range of opportunities outside of the traditional clinical career.

Extreme medicine is an area thats in real growth, and our message to medical professionals is that a traditional clinical career is not the only option any more. Extreme medicine can offer practitioners in all areas of medicine a portfolio career which opens up a huge number of options for work and adventure.

See the original post here:

Women doctors set to take center stage at World Extreme Medicine Conference – News-Medical.net

Surgeon suspended from practicing medicine dies of overdose – New York Post

BISMARCK, N.D. Authorities say a Bismarck oral surgeon who was temporarily suspended from practicing medicine has died from a suspected drug overdose.

The Bismarck Tribune reports that first responders attempted to revive Dr. Mansureh Iravani with Narcan, a drug meant to reverse the effects of opioid overdose. She was pronounced dead Monday night at a local hospital. Police released her name on Thursday.

Investigators say fentanyl, a powerful synthetic opioid, was found inside Iravanis residence.

State regulators suspended the 50-year-old Iravani in March after complaints she pulled the wrong teeth, started procedures without enough sedation and yanked surgical stitches from a patients mouth.

Iravani said after the suspension was announced that the allegations were mostly false and she planned to come back and be a good oral surgeon in this community.

Read more from the original source:

Surgeon suspended from practicing medicine dies of overdose – New York Post

Nebraska Medicine to close inpatient burn unit – KETV Omaha


Nebraska Medicine announced Thursday morning that it will be closing its inpatient burn unit in Omaha.

Patients with serious burns will now be sent to the verified burn center located at CHI Health St. Elizabeth in Lincoln, officials said in a news release.

St. Elizabeth is one of 66 burn centers in the U.S. verified by the American College of Surgeons and the American Burn Association. Every year, the 16-bed unit helps roughly 500 burn patients from six different states.

Nebraska Medicine will continue to care for burn patients at its outpatient clinic, 24/7 trauma center and its medical surgical unit for patients with burns covering less than 10 percent or less of their body.

This decision was made after much careful research and discussion, said Nebraska Medicine Chief Medical Officer Dr. Harris Frankel, in the release. As we transition away from inpatient burn treatment, residents of the Omaha Metro can be assured that our emergency and trauma response for burn patients will be as strong as ever, as will our outpatient clinic care.

The move shows how CHI Health and Nebraska Medicine are working together to eliminate duplication of the specialized service.

Currently, Nebraska Medicine treats about 100 burn patients a year in its unit.

The burn unit is scheduled to close on Sept. 4.

See the rest here:

Nebraska Medicine to close inpatient burn unit – KETV Omaha

Penn Medicine CIO weighs in on precision medicine – MedCity News

As the precision medicine movement gains speed in healthcare, Philadelphia-based Penn Medicine is looking to take advantage of all it has to offer.

Its efforts have undoubtedly been noteworthy. In January 2016, it founded the Penn Center for Precision Medicine, which focuses on precision medicine development and implementation efforts. The center has its own PCPM Accelerator Fund, which supports projects that test unique approaches to how precision medicine impacts patient care.

In a phone interview, Penn Medicine senior vice president and CIO Michael Restuccia discussed the health systems approach to the topic. One key issue, he said, is getting the proper structure in place.

I think most academic medical centers that focus on precision medicine are challenged with their overall organizational structure, Restuccia said. Penn Medicine avoided that pitfall by centralizing the leadership of its medical school and health system.

Another crucial step involves moving to a shared system, which makes it easier to centrally manage information.

Getting the entire institution to move to a common platform allows you to facilitate and share data in a more appropriate manner, aggregate that data more effectively and secure that data in a more efficient way, Restuccia noted.

Indeed, installing technology can be highly advantageous to organizations looking at precision medicine efforts. Because such initiatives involve working with a high number of data sets, tech is the answer to a smoother process.

Technology accelerates data management and data analysis. It also accelerates data integration from the research side back into the electronic record, he said. If you had to do it by hand, it would take decades.

But can IT ever hinder precision medicine advancements? Not really, according to Restuccia. The only downside to tech is from an expectation perspective. Rollouts can take a lengthy amount of time and can be costly from a financial perspective.

Restuccia believes Penn Medicine is already well-positioned to succeed in its precision medicine endeavors. The systems research data warehouse, PennOmics, holds everything from registry data to clinical trials data. Additionally, it is now deployed on a common EMR system called PennChart across the inpatient, ambulatory and home care settings. The data in PennChart can be shared with caregivers from any Penn Medicine location.

Ultimately, thats what we mean when we talk about precision medicine, Restuccia said. Its finding those lessons learned in research and being more proactive in the care provided to each patient.

Photo: StationaryTraveller, Getty Images

Go here to see the original:

Penn Medicine CIO weighs in on precision medicine – MedCity News

Researchers Used Tiny Autonomous Vehicles to Deliver Medicine to the Stomach of Mice – Futurism

In BriefMicromotors the width of a single strand of human hair havebeen used to administer antibiotics to the stomach of micesuffering from a bacterial infection. Micromotor Medic

Researchers usedautonomous vehicles known as micromotors to cure bacterial infections in the stomachs of mice. Micromotors are only the width of a single human hair, which allows themto negotiate the labyrinthine confines of the human body, and administer precise treatment.

In this study, micromotors were used to provide mice with a dose of antibiotics every day for five days. This regimen was found to be more effective than the standard method of administering the medicine.

Micromotors are arelatively new technology, but theyre coming along in leaps and bounds. Earlier this year, researchers in Germany developed a method of combining the vehicles with sperm cells to help combat tumors.

This particular implementation of micromotors is comprised of a spherical magnesium core thats coated with specialized layers that perform various different functions,, like protecting the vehicle, carrying the treatment, and giving it the ability to stick the walls of the stomach.

However, its the core thats the really clever part it propels the micromotor along, but it does so in a way that helps the medicine have the desired effect.

The micromotors are able to move around the stomach thanks to the propulsion provided by the magnesium as it reacts with gastric acid. This reaction actually reduces the level of acidity in the stomach for a short amount of time.

This amounts to more than complementary antacid; antibiotics and protein-based drugs can be rendered useless by the gastric acid in the stomach. As such, its essential that the acidity level be dropped before they are released from the micromotor to do their job. This particular layer of the vehicle responds to the acidity around it, and it will only administer the medicine when it detects safe conditions for it to do so.Click to View Full Infographic

The acidity level of the stomach is said to return to its normal state within 24 hours. The micromotors themselves are largely biodegradable, so when finished, they simply dissolve within the stomach without leaving anything harmful behind.

There is still a long way to go, but we are on a fantastic voyage, said Dr. Joseph Wang, professor at the University of California San Diego and the lead researcher on the project, alongside fellow professor Dr. Liangfang Zhang. Following the success of these tests, the research team plans to engage in a larger study with animals but the long-term goal is to investigate whether the same technique can be used safely on a human subject.

Read the original post:

Researchers Used Tiny Autonomous Vehicles to Deliver Medicine to the Stomach of Mice – Futurism

Nebraska Medicine to close burn center, send patients to St. Elizabeth – Lincoln Journal Star

CHI Health and Nebraska Medicine announced a new collaboration Thursday that will make St. Elizabeth the only burn care center in the state.

Nebraska Medicine said it will close its inpatient burn unit on Sept. 4. It will continue to care for burn patients in trauma situations and on an outpatient basis, but all patients needing inpatient burn care will be sent to CHI Health St. Elizabeth.

St. Elizabeth is one of 66 burn centers in the U.S. verified by the American College of Surgeons and the American Burn Association. The unit has 16 beds and serves an average of 500 burn patients from a six-state area each year. Nebraska Medicine treats about 100 burn patients a year.

This decision was made after much careful research and discussion, Nebraska Medicine Chief Medical Officer Harris Frankel said in a news release. “As we transition away from inpatient burn treatment, residents of the Omaha metro can be assured that our emergency and trauma response for burn patients will be as strong as ever, as will our outpatient clinic care. Well work closely with the staff at St. Elizabeth to make sure burn patients receive the right care in the right center.

The two hospital systems said the move shows they are working together to eliminate the duplication of this highly specialized service. Consolidating inpatient care to one burn unit lowers the overall cost of care for patients and employers, while still ensuring patients have access to high-quality care.

The team of highly skilled and specially trained physicians, nurses and therapists welcome the opportunity to care for more burn patients. Cary Ward, CHI Health chief medical officer said in the release. This collaboration is a perfect illustration of how health systems are working together to reduce costs and improve quality of care through specialization.


Nebraska Medicine to close burn center, send patients to St. Elizabeth – Lincoln Journal Star

‘Micromotors’ alter your gut’s chemistry to safely deliver medicine – Engadget

Conventionally, the medication used to treat maladies like ulcers or bacterial infections, have to be administered alongside a secondary compound known as proton pump inhibitors. These chemicals temporarily halt the production of stomach acid, allowing the medicine to do its work without being destroyed. However, long term use of PPIs can make matters much worse, from headaches and fatigue to anxiety and depression.

UCSD’s “micromotors” are made up of a titanium dioxide protective shell surrounding a spherical magnesium core. Above the TiO2 layer is a layer of antibiotic medication and above that,is another layer made up of a positively-charged polymer that helps the motor stick to the gut wall.

Now here’s the really cool part. These motors use the stomach’s own acid as a fuel source. The magnesium layer reacts to the gastric acid to generate a stream of hydrogen bubbles to produce thrust, while also reducing the amount of acid present. Once the stomach’s pH hits the correct level, the motors release their medication and finish dissolving.

These devices are still in the early days of their development so don’t expect to have your antibiotics squirming through your belly for a few years yet at least.

See original here:

‘Micromotors’ alter your gut’s chemistry to safely deliver medicine – Engadget

Washington Redskins Charitable Foundation & Inova Sports Medicine To Host High School Coaches Clinic – Redskins.com

EASY TWEET: .@RedskinsCR & @InovaHealth to host free clinic for 100 high school football coaches

LOUDOUN COUNTY, Va. The Washington Redskins Charitable Foundation will host the Washington Redskins High School Coaches Clinic presented by Inova Sports Medicine on Friday, Aug. 18 from 11 a.m. 1:15 p.m. The clinic will take place at the Inova Sports Performance Center at Redskins Park where participants will be able to watch walk-through in the indoor practice facility followed by a panel discussion in the auditorium and lunch in the Redskins dining room.

Approximately 100 high school coaches from Washington, D.C., Maryland and Virginia are expected to participate in the clinic, which includes a panel discussion led by Voice of the Washington Redskins Larry Michael. Panelists will be Redskins coaches including Offensive Coordinator Matt Cavanaugh, Defensive Coordinator Greg Manusky and Special Teams Coordinator Ben Kotwica. Redskins Senior Vice President of Player Personnel, Doug Williams, and EXOS Performance Director of Pro Sports, Brent Callaway, will headline the keynote speaker portion of the clinic. Special guests will include Redskins President Bruce Allen and Head Coach Jay Gruden.

The annual Washington Redskins High School Coaches Clinic presented by Inova Sports Medicine provides coaches with information on player health and safety, character development and how to build a successful program on and off the field.

Media availability for the Washington Redskins High School Coaches Clinic will begin at 11:30 a.m. (the start of the speaking portion). Media interested in attending the event should contact Tish Carmona of Redskins Public Relations at carmonat@redskins.com or 703-726-7077 to obtain a credential.

For more information on the Washington Redskins Charitable Foundations programs and events or to donate, visit http://www.redskins.com/community or follow the Foundation on Twitter at @RedskinsCR or Instagram at @RedskinsGiveBack.

Read more:

Washington Redskins Charitable Foundation & Inova Sports Medicine To Host High School Coaches Clinic – Redskins.com

NIH gives nod to Vibrent Health for precision medicine work – Healthcare IT News

Vibrent Health’s cloud-based precision medicine platform has gained authority to operate from the National Institutes of Health, a certification that it meets federal privacy and security standards and paving the way for the company’s work on the landmark research cohort that will fuel the Precision Medicine Initiative

“This ATO certification marks a significant milestone for Vibrent in its journey to power the next generation of personalized medicine,” said the company’s CEO Praduman Jain, in a statement.

Vibrent’s SaaS platform combines genomic information with data from electronic health records, medical devices, wearables and more.

[Also:NIH All of Us program gearing up for ‘precision engagement,’ Eric Dishman says]

It will be the technology around which the All of Us Research Program will be based as the precision medicine project works to enroll more than one million participants in its cohort to understand how genomics, lifestyle, behavioral, and environmental factors impact an individuals health.

In addition to NIH, Vibrent’s technology is at use at Johns Hopkins, Stanford, the U.S. Veterans Administration, UnitedHealth Group and Medtronic.

For the ATO certification, the company worked with Coalfire, a third-party assessment organization, to develop security plans, policies, procedures, scanning, SSP, and pen testing, per FISMA risk management framework, to ensure the integrity of its platform, officials said. Coalfire confirmed that Vibrent Health has the necessary operational and technical controls in place to provide a secure environment for federal systems, bureaus, departments, and their supporting entities.

Twitter:@MikeMiliardHITN Email the writer: mike.miliard@himssmedia.com

Like Healthcare IT News on Facebook and LinkedIn

The rest is here:

NIH gives nod to Vibrent Health for precision medicine work – Healthcare IT News

Swimmer drowns in river near Medicine Hat – CBC.ca

A 40-year-old man has drowned in the South Saskatchewan River just west of Medicine Hat, Alta., according to police

RCMP said the man was swimming near Echo Dale Regional Park on Tuesday afternoon when he started struggling and slipped under the water.

A family member managed to swim to him and pull him to a small island in the middle of the river.

Within minutes, two men in a boat came by to help out by calling 911, bringing the pair to shoreand starting resuscitation attempts.

Paramedics arrived and continued to try to resuscitate the man, who was taken to the Medicine Hat Regional Hospital, where he was pronounced dead.

Read the original:

Swimmer drowns in river near Medicine Hat – CBC.ca

Oly Ortho’s Sports Medicine Team Keeps Thurston County Moving – ThurstonTalk

Every three months a group of highly trained sports medicine doctors, primary care physicians, chiropractors, physical therapists and athletic trainers gather to discuss the latest literature and best practices in the field of Sports Medicine. These healthcare professionals work together to make sure their patients are receiving cutting edge care. You may think that this type of high level care and collaboration is only available in major metropolitan areas. However, this is all happening right here in Thurston County at Olympia Orthopaedic Associates.

As the field of orthopaedics becomes more specialized, so does Olympia Orthopaedic Associates. They have expanded their clinic to meet the needs of our growing, active community. There are now many subspecialty clinics within the organization to serve a diverse patient population. Two examples of Centers of Excellence found within the group are the Foot and Ankle Clinic and the Hand, Wrist and Elbow Center. Another specialized area is run by the Sports Medicine team, including both operative and non-surgical practitioners. Dr. Femiano and Dr. Hamblin have both completed fellowships in sports medicine and their commitment to continued education ensures that they are actively learning the newest procedures and techniques.

One example of their cutting-edge treatment is the use of ultrasound guidance to administer a PRP or cortisone injection, providing relief and keeping athletes moving. The clinic is also very close to providing stem cell injections which can play a significant role in reducing inflammation in knee and hip joints. Read more about PRP injections at OOA here.

We are providing a multi-disciplinary, community based program, explains Rebecca McClinon, OOA Sports Medicine Program Coordinator. OOA provides surgical and non-surgical solutions to many of the orthopaedic issues affecting everyone from student athletes and ultra marathoners to the weekend warrior. When there is a more appropriate course, OOA can reach out their community partners as well. Working in partnership with local chiropractors, athletic trainers and physical therapists, we have created an umbrella of care for the physically active in the community, shares McClinon.

As a fellow weekend warrior, I know that many people will delay seeking care for their aches and pains. Runners and bikers fear that a visit to the doctor may result in a diagnosis that sidelines their activities. Fortunately, at OOA, that is not necessarily the case. The physicians and staff are active individuals as well and understand that staying in the game is important to patients. Whenever possible, a less invasive techniques can be used to treat an injury or alleviate pain. A tennis elbow or the common Achilles tendinitis can be relieved with a Tenex procedure completed right in the office. A small incision is made and a vibrating burr, a brush like instrument, removes the scar tissue and creates a rapid healing response.

In the case where surgery becomes necessary, Dr. Bradley Christ and Dr. Trent McKay have been specially trained in both minimally invasive arthroscopic treatment of key areas such as shoulders and knees as well as full replacement joint surgeries.

In addition to treating patients in the OOA clinic, Drs. Hamblin and Femiano are heavily involved in the community. They provide sports medicine services to the athletic departments of South Puget Sound Community College, Saint Martins University, The Evergreen State College and local area high schools.

Each Friday night, OOA Sports Medicine physicians provide coverage for all three stadiums in our area. There is an doctor on site at every high school football game. As the parent of a student athlete, that commitment to our youth is particularly important.

Area high school and college athletes also benefit from the low-cost/no-cost sports physicals that OOA provides. We partnered with TOGETHER!, Tumwater Family Practice, Providence Tumwater Valley Physical Therapy, Providence Sports Medicine, St. Peter Family Medicine, Tumwater Vision, Tumwater School District Health and Wellness Department and local school districts to provide these free sports physicals to as many students as possible, explains McClinon. On one Tuesday evening at a local high school gym they completed 250 physicals in just three hours. Tumwater soccer player Sarah shares, It was really fast and fun. We went to different stations to be tested and it saved my parents time and money, so we really appreciated the opportunity.

OOA extends that community outreach to area events such as the Black Hills Triathlon and the Capital City Marathon as well. OOA also plans to collaborate with local school districts in their Unified Sports program. Currently providing soccer and basketball, Unified Sports joins students with and without disabilities on the same athletic team. OOA is dedicated to supporting these programs that provide social inclusion for all student athletes.

From community support to cutting-edge techniques and treatments, the team at Olympia Orthopaedic Associates Sports Medicine Clinic are ready to help Thurston County citizens enjoy a Life in Motion.

For more information on the Sports Medicine Clinic at OOA visit their website http://www.olyortho.com


See the rest here:

Oly Ortho’s Sports Medicine Team Keeps Thurston County Moving – ThurstonTalk

Ranch Medicine subject of talk at Phippen Museum – The Daily Courier

Local author and historian Jody Drake will present On the Arizona Frontier: Ranch Medicine at 1 p.m. Saturday, Aug. 19, at the Phippen Museum. The talk is free with museum admission, and will cover what frontier families had to deal with when doctors werent available.

Many early residents learned that local plants and other resources held the answer for curing different illnesses. Chew a little willow bark for a headache, make a tea rich in vitamin C with pine needles, and close up cuts with spider webs. These and other home remedies were commonplace on the Arizona frontier.

Drake has performed throughout the state and her first-person presentations mix the rich stories of the West with an enchanting combination of humor and fact. She also will explore the fascinating contents often included in the typical frontier medical bag, allowing attendees to take an in-depth look at some of the tools and instruments used in late 1800s Arizona.

The Phippen Museum is located at 4701 Highway 89. For more information, call 928-778-1385 or visit http://www.phippenartmuseum.org.

See the rest here:

Ranch Medicine subject of talk at Phippen Museum – The Daily Courier

Stanford Medicine X conference to focus on creating positive change in health care – Stanford Medical Center Report

Medicine X, Stanford Universitys premier conference on emerging health care technology and patient-centered medicine, will return to campus Sept. 15-17.

This years conference, which will be held at the Li Ka Shing Center for Learning and Knowledge, will focus on the responsibilities of health care citizenship and how individuals can take action to improve health care in the United States.

Medicine X 2017 will focus on how we can take action to create the change that we want to see in the health care system and move beyond ideas into action, saidLawrence Chu, MD, professor of anesthesiology, perioperative and pain medicine at Stanford and founder and director of Medicine X. With the current uncertainty in the future of health care, its important to stop and consider how each of us might work to create a new culture of caring in health care that doesnt exist right now.

Medicine X aims to bring together everyone who plays a role in health care researchers, patients, providers, designers, technologists and policy leaders and encourage them to work together to build a framework for health care transformation, Chu said. This framework, known as Everyone Included, is a trademark of Stanford Medicine X and was co-developed with a diverse group of health care stakeholders over the past seven years at the conference.

In January during President Obamas farewell speech, he talked about how his future role was going to be as a citizen, Chu said. That inspired me to think about how we, as individuals, might consider this role in terms of health care. We hope this conference will give people both the inspiration and the tools and resources they need to take action and create change.

Here is the original post:

Stanford Medicine X conference to focus on creating positive change in health care – Stanford Medical Center Report

Alternative medicine for cancer more than doubles death risk – New York Daily News

Ys8.6@9ebcl9/J+pD q4u)|`%=sG9#F”V Q+9 #Kfp& pqwv$9:N9` d$lNxA~”G.I,N b:C,@){tiBd)*8JqFF3ClI8!)[9?$S2;vh*M4]B)m`;viFOedep~Y@ 1oBK&q|8}/jlJ9AvjT>Qfcx~'{h BQ@ p6# t y:iuinc[P|6jtJtjt%!r6rK“EzZq5*HCE`+qRK4″SpI9kjfWZ#f%GZ6 YWKAJI^1ct^8!i;e{. 8@? H,1@L#TC4 =@phGnwfi6%N~x@(K]G]iOCh;Mg8;QArz::NzOQL$K8jYY’YUiF’4l[yx`a-FRZFMj&5!wK’b8&+U?eR;;J U;u ~O,fwmfV;sOg~> 3@7oa+u5U.c`( ]O6xrY^X>’C,N]^z”p:;:q syW B2pE wnyBb75%C afMd4.eX:Yz p7A[ou9=:@ YQJf 1{(D5(&*jKtUj PJcX}o85avw:;89~?gyI_>|BW~rzy% ic?U_z~YJSJa?;@- >hyvn_v|w8uB)9B|u% nnT=3gh{7bL_N#l.;J*q’ Ul[oC3OksZA.,F5FFOmKo7/[@s~~){WRWRgC][aO>}=]:’xz0@zVGue9.> QAtbmu(T?Mxk‘gOwcEvw(^8`OPi*8 HnpZ {,~9~{u’)gz{kz$%5IQu[x9%n3?b-~j`rA%d)~2}xK95Gs,?f”xm?*}ztn~7WGl?!G*!>FsSC&ztyeI?}d2z|n9`?z xtW>.{6r?C%TWZ?_QV bO~Jd^m%`h5K +\TaGo|W5oI?H PkC~ ;J?oVWIt5>K?2^~f9H?v >~TVMWLO|) UGs57;(VIK($’ +gh{Bi_@w` 3,”(qcA@2np[-3:7;A/dk=Q-a:,a+IE:iW=V –dBAj^I_1_O|Bxf#rmcyR_]8giV:uQ)3Ai>Ih54G {rA@63?qaa-Av-RcX=cD!b*E,]}+s1Y “$,oRw%+c5U_vJEI%]o *TgqCH-!z(P 1″dTWWn4tRM 4aa!>g?wOe6ae4GPQfsg4itrX_7Q0CO=FPTO>FH@]Xce5z9 0VkEEgtLpH~JcE*=H0J>QezBq1+0*G`Cq9#7 n@AMC&l$R(g9TYm#]?FhJ9{OY[wHAx&r).o*kE_?PLwO5k&Sg,6tI6vI’FJKBuJlvP1J|6-.Uw Y0dWQ?o8XI<_4av q6>

Precision Medicine for Preventing Suicide – Genetic Engineering & Biotechnology News

A research team led by scientists at the Indiana University (IU) School of Medicine say they have created a novel method for diagnosing suicide risk by developing blood tests that work in everyone as well as more personalized blood tests for different subtypes of suicidality and high-risk groups.

The researchers also demonstrated how two appsone based on a suicide-risk checklist and the other on a scale for measuring feelings of anxiety and depressionwork along with the blood tests to increase the precision of tests and to propose potential lifestyle, psychotherapeutic, and other interventions. The team also noted that they were able to identify a series of medications and natural substances that could be developed for preventing suicide.

Their study (“Precision Medicine for Suicidality: From Universality to Subtypes and Personalization”) is published in Molecular Psychiatry.

We sought to investigate whether blood gene expression biomarkers for suicide (that is, a liquid biopsy approach) can be identified that are more universal in nature, working across psychiatric diagnoses and genders, using larger cohorts than in previous studies. Such markers may reflect and/or be a proxy for the core biology of suicide. We were successful in this endeavor, using a comprehensive stepwise approach, leading to a wealth of findings, write the investigators.

Steps 1, 2 and 3 were discovery, prioritization and validation for tracking suicidality, resulting in a Top Dozen list of candidate biomarkers comprising the top biomarkers from each step, as well as a larger list of 148 candidate biomarkers that survived Bonferroni correction in the validation step. Step 4 was testing the Top Dozen list and Bonferroni biomarker list for predictive ability for suicidal ideation (SI) and for future hospitalizations for suicidality in independent cohorts, leading to the identification of completely novel predictive biomarkers (such as CLN5 and AK2), as well as reinforcement of ours and others previous findings in the field (such as SLC4A4 and SKA2).

“Our work provides a basis for precision medicine and scientific wellness preventive approaches,” said Alexander B. Niculescu III, M.D., Ph.D., professor of psychiatry and medical neuroscience at IU School of Medicine and attending psychiatrist and research and development investigator at the Richard L. Roudebush Veterans Affairs Medical Center.

The multistep research approach began with serial blood tests taken from 66 people who had been diagnosed with psychiatric disorders, followed over time, and who had at least one instance in which they reported a significant change in their level of suicidal thinking from one testing visit to the next. Using the Niculescu group’s Convergent Functional Genomics approach, the team prioritized the candidate gene expression biomarkers that were best associated with suicidality in each individual and across individuals.

The researchers then tested the validity of the biomarkers using blood samples drawn from 45 people who had committed suicide. The biomarkers were subsequently tested in another group of individuals to determine how well they could predict which of them would report intense suicidal thoughts or would be hospitalized for suicide attempts.

The researchers identified RNA molecules as the biomarkers whose levels in the blood changed along with changes in the levels of suicidal thoughts experienced by the patients.

Among the findings reported in the current paper were:

Dr. Niculescu points out that while suicide can impact individuals in all walks of life, he believes such tragedies can be averted.

This landmark larger study breaks new ground, as well as reproduces in larger numbers of individuals some of our earlier findings,” he said.

Continue reading here:

Precision Medicine for Preventing Suicide – Genetic Engineering & Biotechnology News

University to offer 50 places to study medicine through clearing this week – GP online

A London medical school said it is braced to receive thousands of calls this week as it opens up around 50 places on its medicine degree through clearing for the second year running.

St George’s medical school, at the University of London,said it was enormously keen to run the programme again following its success last year, the first time medical school places were offered through clearing in the UK.

Around 50 places on its five-year medicine course, commencing this year, will be available through clearing, but competition for the last-minute spots is set to be fierce.

GPonline reported that the clearing hotline was inundated with 1,800 calls just hours after A level results were released last year. Over 8,000 enquiries were eventually made in total.

This year, St George’s has increased its call handling team two-fold to help meet the anticipated demand on results day this Thursday from hopeful candidates.

Clearing is usually used by universities to fill up any leftover places, but St George’s said that it had purposefully set aside the clearing places to account for the unpredictability of A level grades, rather than them being available as a consequence of inadequate interest in its medicine course.

The move will offer a lifeline to students who otherwise would have missed out and allow more top achievers a chance to study medicine without having to delay their ambitions for another year, it said.

All students are expected to get at least grade A in all subjects and will be interviewed and scrutinised in the same way as students who apply before results day.

Ameera Cajucom, a student who won a place through the scheme last year, said: I think that going through clearing for St George’s was life changing, practically a miracle. I didn’t realise how much it was the university for me, the life and the culture is perfect.

Professor Jenny Higham, principal of St Georges, said: Following clearing and adjustment last year, many outstanding students, who could not gain a place elsewhere, are now on the road to fulfilling their dreams of becoming a doctor or pursuing another specialism.

We are enormously keen to open our doors to students with the same drive and ambition this year.

The school will also offer clearing places on a number of other courses, including biomedical science, physiotherapy and paramedic science.

Excerpt from:

University to offer 50 places to study medicine through clearing this week – GP online