UAB professor, recruiter talks importance of diversity in School of Medicine – WVTM13

UAB professor, recruiter talks importance of diversity in School of Medicine

Updated: 11:04 PM CDT Jul 21, 2020

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GUY: HEALTH CARE WORKERS HAVE BECOME SOME OF THE MOST ESSENTIAL FOLKS DURING THIS PANDEMIC, AND EVEN MORE ARE NEEDED. UAB MEDICAL PROFESSOR, DR. RAEGAN DURANT, JOINS US TONIGHT TO TALK MORE ABOUT RECRUITING BLACK STUDENTS FOR MEDICAL SCHOOL. THANK YOU FOR YOUR TIME THI EVENING. THE COVID-19 VIRUS HAS SIGNIFICANLTY EXPOSED HEALTHCARE DEFICIENCIES IN THE BLACK COMMUNITY. ONE OF THE ISSUES THAT COMES UP IS THE BLACK COMMUNITYS DISTRUST OF THE HEALTHCARE SYSTEM IM SURE THERE ARE A LOT OF REASONS WHY THAT IS. WHY DO YOU THINK THAT IS? DR. DURANT: THE DISTRUST IS EMBLEMATIC OF BROADER DISTRUST OF THE HEALTH CARE SYSTEM. MUCH OF THE INFORMATION THAT HAS BEEN DISSEMINATED RELATIVE TO COVID-19, THE PANDEMIC. I THINK WHAT WE SEE IN THE AFRICAN-AMERICAN COMMUNI IS THAT DISTRUST MAY BE EVEN MORE INTENSE DUE TO THE LEGACY OF DISCRIMINATION, LEGACY OF ABUSE IN MEDICINE AND RESEARCH. ALL OF THOSE THINGS COMBINE TO LEAD TO A HEIGHTENED LEVEL OF SUSPICION. GUY: 13% OF THE TOTAL POPULATION IS BLACK BUT ONLY 5% OF DOCTORS ARE AFRICAN-AMERICAN. WHY DO YOU FEEL THAT NUMBER IS NOT HIGHER? DR. DURANT ONE OF THE DIFFICULTIES AND CHALLENGES OF INCREASING THE NUMBER OF AFRICAN-AMERICANS IN THE PHYSICIAN WORKFORCE IS JUST THE PATHWAY. YOU HAVE TO START WITH PEOPLE APPLYING FOR MEDICAL SCHOOL AND THEN OF COURSE PURSUING CAREERS IN MEDICINE. THE NUMBER OF APPLICANTS IS DISPROPORTIONATELY SMALL. THE KEY IS INCREASING THE NUMBER OF -- GU HOW DOES SEEING SOMEONE LIKE YOU IN THE WHITE COAT IN YOUR DOCTORS OFFICE AFFECT OVERALL HEALTH CARE? DR. DURANT YOU KNOW, IT H POTENTIALLY A VARIETY OF EFFECTS. IN SOME RESPECTS, GENERALIZATION HOWEVER, THERE ARE OFTEN TIMES I WALK IN TO A PATIENTS ROOM, IVE NEVER MET THEM BEFORE, IT IS AN AFRICAN-AMERICAN PATIENT, AND THERE IS A LOOK OF SURPRISE. A PLEASANT SURPRISE. I THINK IT IS COMFORTING FOR SOME AFRICAN-AMERICANS BECAUSE THERE IS A PRESUMPTION OF A SHARED BACKGROUND AND CULTURAL FRAMEWORK. ON T WHOLE, IT CAN BE REASSURING. THAT IS NOT TO SAY IN THOSE INSTANCE WHEN AN AFRICAN AMERICAN PATIENT IS SEEIN SOMEONE OF ANOTHER RACE THAT DR. CANNOT CONNECT WITH THE PATIENT IN AN EFFECTIVE MANNER. BUT THERE IS A SHARED CONNECTION OFTENTIMES WHEN AN AFRICAN-AMERICAN PATIENT SEES AN AFRICAN-AMERICAN PHYSICIAN. GUY: IN RECRUITING WHAT ROADBLOCKS DO YOU COME ACROSS TO BRING MORE AFRICAN-AMERICANS TO THE BUSINESS OF DOCTORING? DR. DURANT: THERE ARE A NUMBER OF CHALLENGES. ONE OF THEM IS JUST ROLE MODELS. THEN IT BECOMES A CHICKEN AND EGG PHENOMENON. NAMELY THAT THERE ARE TO FEW AFRICAN-AMERICAN PHYSICIANS CURRENTLY AND THAT RESULTS IN FEWER ROLE MODELS FOR YOUNG STUDENTS WHO MIGHT BE INTERESTED IN MEDICINE. THEREFORE IF OF THEM CHOOSE A CAREER IN MEDICINE. THERE ARE ALSO STRUCTURAL BARRIERS IN THAT MEDICAL EDUCATION AS WELL AS ALL HIGHER EDUCATION AT THIS POINT IS VERY EXPENSIVE. $40,000 TO GET A MEDICAL DEGREE THESE DAYS. IF YOU HAVE A PERSON -- PEOPLE LIKE AFRICAN-AMERICAN SWORDS PROPORTIONATELY F -- WHO ARE DISPROPORTIONATELY POOR, THAT MAKES IT HARDER IN TERMS OF WHAT CAN BE ALLOCATED AND WHAT IS AVAILABLE. STATISTICS HAVE SHOWN AFRICAN-AMERICANS ARE MORE LIKELY TO FALL IN THE HIGHEST CATEGORY OF DEBT FOLLOWING UNDERGRADUATE INSTITUTIONS. ALL OF THESE THINGS COMBINED, THE ABSENCE OF ROLE MODELS, THE MONEY NEEDED TO RECEIVE A MEDICAL EDUCATION, AND FRANKLY, THE TIME INVESTED ALL OF THOSE THINGS COMBINE TO CHALLENGES TO RECRUITING AFRICAN-AMERICANS.

UAB professor, recruiter talks importance of diversity in School of Medicine

Updated: 11:04 PM CDT Jul 21, 2020

WVTM 13's Guy Rawlings interviews Dr. Raegan Durant, a professor and recruiter at the University of Alabama at Birmingham, about the importance of diversity in UAB's medical school program. Watch the full interview in the video above.The MD program has a diversity dashboard that can be viewed by clicking here. To contact Dr. Durant, click here.

WVTM 13's Guy Rawlings interviews Dr. Raegan Durant, a professor and recruiter at the University of Alabama at Birmingham, about the importance of diversity in UAB's medical school program. Watch the full interview in the video above.

The MD program has a diversity dashboard that can be viewed by clicking here.

To contact Dr. Durant, click here.

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UAB professor, recruiter talks importance of diversity in School of Medicine - WVTM13

From Facemasks to Medical Masks: Jared and Jeremy Watson – Bama Maven

My first symptom was fatigue and then a headache, Jeremy Watson said. From there I started to lose my feel of smell and taste and a couple of days after losing my sense of smell I started to feel very very weak and also started to feel this pins and needles-type sensation in my skin. From there I started to have worse headaches and my fever kicked in."

After being tested, Watson discovered his concerns had been realized: he had contracted COVID-19.

The story of Jared and Jeremy Watson might not be the most well-known tale among Alabama football fans, but that does not make it an uninteresting one.

Raised in the Tuscaloosa area, Northport to be specific, the twins were understandably inseparable from birth. They did nearly everything together, and both had aspirations to do what many young boys in the state of Alabama wish to do when they grow up.

Growing up in the Tuscaloosa area I feel like its every little boys dream to play for Alabama, Jeremy said. That was just something that I always wanted to do.

Football wasnt the only dream, though. At a very young age, both came to the realization of what career they wanted after their football-playing days were over.

We both wanted to be doctors since we were about five years old, Jared said. We actually remember sitting on the floor drawing little comic books one day and we told our mom and dad that we would be football-playing doctors in space.

So far, so good.

Courtesy of Jared and Jeremy Watson

After playing as wide receivers for Tuscaloosa County High School, they graduated and headed to the University of Alabama on academic scholarships in the fall of 2010 to begin the process of becoming doctors.

After their freshman year and establishing themselves as pre-med students, the time was finally right to pursue their other passion.

We were pretty undersized and underdeveloped coming out of high school, Jared said. There were no offers or anything like that. We came to Alabama on academic scholarships and thought wouldnt it be crazy just to give it a try and what if?

The brothers, both just over 6-foot tall (Jeremy is taller at 6-1) attended team tryouts before their sophomore year but were among the final cuts. Despite disappointment, the brothers didn't give up.

After seeing the team win the national title in New Orleans against LSU, the Watsons renewed their focus on making the team for their junior year.

The way the whole process was of earning a spot on the team really just from that starting point it played a huge role, Jared said. Putting in the work and it not working out the first time and not giving up and coming back and doing it again and it working out the second time around is something fighting through the adversity of disappointment.

After all of their hard work and after another grueling summer of tryouts, both brothers had their efforts rewarded. After being issued the final team roster, both Jared and Jeremys names were on the list.

I didnt join the team expecting to be an All-American or anything like that, Jared said. Honestly I feel like making the team just coming from being so under-polished coming out of high school and seeing that hard work pay off and making the roster it was nice being a part of something that was bigger than me. Thats one of the major things that I took away from it.

Some of the friendships and the lessons I learned, that was really the more significant thing to me.

The duo both played as walk-on wide receivers for their junior and senior years, including earning national championship rings for the Crimson Tide in Miami against Notre Dame in 2013.

Alabama Athletics

After graduating from Alabama, Jared and Jeremy traded in their football facemasks for medical masks and began to attend medical school. Jared was accepted to the University of Alabama at Birmingham School of Medicine while Jeremy left his home state to attend Howard University College of Medicine in Washington, D.C.

Medical school is tough, Jared said. Its challenging. A lot of hours that you have to put into it and you know and every day your best effort is demanded and that was something that coach [Nick] Saban wanted from each and every player whether they were the Heisman finalist or a walk-on like us he demanded the same. He had the same expectations for everybody. Learning to take that kind of accountability for yourself and put your best self forward every day was something that really stuck with me and something that I really needed to take my next step forward through medical training.

Jeremy echoes Jareds statement.

The attention to detail in regards to your preparation for a game, Jeremy said. All week we would pay excruciating detail to all the little things and when you apply that to medicine and medical school its always important to drill home all those small, minute details. Thats really helped me a lot. Also just the idea of mental toughness. Thats something coach Saban likes to say: being mentally tough.

Which brings us back to the present day. Both brothers are in their final year of medical school and preparing for residency. However, back in March, Jeremys contraction of the novel coronavirus provided a new focus on their work.

After going through the initial symptoms, Jeremy said that he slowly began to feel better. First his headaches and fever went away, then after about 10 days his taste and smell returned. After self-quarantining for the two-week period, Jeremy was able to return to school.

While his symptoms were mild, Jeremy said that the virus is something that everyone should be taking seriously, and those who dont consider it a threat should highly reconsider.

I think thats a very irresponsible way to look at the virus, Jeremy said. You dont know how its going to affect your body or someone elses body. There are lots of people walking around that are affected that are asymptomatic and theyll pass it to someone in the grocery store and you dont know what that person is dealing with their health. That could send them to the ICU. Its very important that were all responsible and think of each other rather than thinking of ourselves when it comes to this virus.

A lot of people like to mention oh its just a one-percent death rate but when you look at the numbers and really figure out what one percent of that really large number is, thats a lot of people that are passing away from this virus and a lot of those deaths could have been prevented by just adhering to the guidelines from the CDC and just thinking of your neighbor.

Jared said that when he first found out that his brother had tested positive, he was initially worried because his brother lived so far away.

I was more a little shocked, Jared recalled. I was just concerned that he was ok and you know being kind of separated it made me worried. Knowing that he had to isolate, all those kind of things it just made me concerned that he would be ok by himself. He kept us updated. He called home, called my mom and dad, called me often. We checked in on him a lot.

Courtesy of Jared and Jeremy Watson

Jeremy was able to make a full recovery. However, his perspective on the virus due to his first-hand experience has him encouraging other to step up to the plate and take responsibility for not just oneself, but others.

His first bit of advice? While Jeremy has worn multiple versions of a mask throughout his life on both the gridiron and the hospital, he encourages others to follow the guidelines and don masks of their own.

Continue to wear your mask, Jeremy said. I know thats a hot topic for debate right now but wearing a mask not only protects you, it protects your family and it protects other peoples family. I know a lot of people feel as if being mandated to wear a mask is imposing on their rights of doing whatever they want. To me I feel that that stance is a little selfish because you never know what another person may be dealing with. They may be immunocompromised or something like that. Throwing a mask on maybe uncomfortable but youre doing your neighbor a favor and protecting them from what could be a really deadly disease. We never really know how the disease will affect someone and Im really grateful that I had a lighter course of the disease.

Jeremy also offered two more tips for those who want to maintain proper precautions,

Also, continuing just to wash your hands, Jeremy said. Sanitize your cell phone. We always touch our cell phones and no one really thinks to wipe their phone every day at least most people dont.

Courtesy of Jared and Jeremy Watson

Both Jared and Jeremy have been on quite a journey throughout their lives, and its only just beginning. Both have played football at the school they wanted to attend since they were kids and are now on track to become doctors in the near future.

So what about the astronaut portion of their childhood dreams?

You never know with SpaceX, Jared laughed.

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From Facemasks to Medical Masks: Jared and Jeremy Watson - Bama Maven

The Autistic Brain and Early Intervention – tulsakids.com

Ive had a lot of kids come to me who couldnt read, says Dr. Edward Gustavson, a developmental-behavioral pediatrician in Tulsa. Theyre bright, 7 or 8 years old, but they cant read. They cant read because they cant concentrate. These kids live in a rock concert.

Autism spectrum disorder (ASD) is a diagnosis of abnormal sensory processing, Dr. Gustavson says. The disorder is much more prevalent in boys than girls; however, girls symptoms are often more severe. In 2020, the CDC reported that approximately 1 in 54 children in the U.S. is diagnosed with ASD, according to 2016 data.

Dr. Gustavson

Gustavson, M.D., F.A.A.P., is a graduate of Harvard Medical School, a fellow of the American Academy of Pediatrics, and was clinical director of the Childrens Medical Center in Tulsa until it closed. He has been practicing developmental medicine for much of his extensive career and currently is in private practice in Tulsa.

Gustavson uses the rock concert analogy to describe the sensory bombardment that children with ASD experience.

They have too many brain cells, he says. All five senses are overly sensitive.

Electronic imagery, MRIs and varied observations and measurements of the cerebral cortex with its excessive layers provide research markers that show what happens in the child destined to have ASD.

The normal fetal brain during middle pregnancy has many more brain cells, called neurons, than it will need, Gustavson explains. The bulk of the causes of ASD are related to environmental exposure in terms of the neurology or epigenetics in the womb.

During normal fetal brain development, a pruning process happens to reduce excessive connections in order to direct the senses to normal sensory action and communication. However, this reduction of cells and connections doesnt occur in the child with ASD, which results in an over-connected brain.

The most important of these connections concerns the visual and verbal cues, which prompt useful language. If this reducing or pruning doesnt occur, the child will hear sounds as if experiencing electronic interference, with resulting lack of comprehension.

Albert Einstein, whose brain was studied after his death, Gustavson says, was found to have doubled thickness layers; he spoke little until age 4, resulting from hearing too much, not too little.

Dr. Gustavson says that parents typically bring children to see him when the children are either not talking or not reading. He would like to see children as young as possible because the earlier therapy is started, the better the outcome.

Children should be evaluated if theyre not having language, and theyre not connecting with the mother or another person like a grandmother or caregiver.

Dr. Gustavson describes a former fifth-grade patient who was having problems connecting with other children at school. The boy was being bullied, yet the school wouldnt accommodate his social differences because he was academically successful. Gustavson worked with him, and the boys mother enrolled him in a different school where his unique abilities could be accommodated, and the class sizes were smaller.

He became a star, Gustavson says. Those with ASD can learn relationships if people give them the chance and dont push them into negative behavior patterns. They can learn to function, but not be neuro-typical; they can learn to have conversation and connection, but not be expected to process the same way as a neuro-typical person.

Schools can accommodate children with ASD by ensuring that they are not over-stimulated. For example, putting them in the front of the class where they dont have to look through a sea of students to pay attention to the teacher, or allowing them to skip noisy assemblies. Providing a predictable environment and a para-teacher can also help.

Unlike a regular pediatrician, a developmental pediatrician spends at least an hour evaluating a child. Gustavson says he has always opted for spending time quietly and slowly observing, evaluating and talking with his patients in treatment rather than taking a more financially lucrative path. While the coronavirus has forced more internet home observations, Gustavson says that they are sometimes more telling than office visits.

A child with ASD does not focus into the eyes of the examiners. Often the child hides the eyes and makes repetitive sounds or movements, he says, but these are not too different from the actions of other children in a strange situation. In some ways, the observations I make as a doctor via confidential internet sessions of home behavior mean more. At home in quarantine with the mothers full attention, erratic and aggressive behavior, even ADHD, is likely to be more easily observed.

Gustavsons approach is practical and pragmatic. He believes that the sooner therapy begins, the better the results. Swedish studies show that it is critical to establish language as soon as possible in order to see optimum outcomes. So, rather than spending weeks or months in the evaluation phase, Gustavson begins therapeutic work after a much shorter evaluation than might typically be done, for example, in a hospital setting. He also helps parents learn to establish a consistent, quiet, predictable home environment as well as giving them methods to work with their children at home.

If necessary, Gustavson may use simple, non-addictive medications, but says the medicine is the opposite of stimulants for ADHD. Medication is just to permit a reduction in the excessive input in order to work with the child.

The medication for ADHD can make the child with autism worse, Gustavson says.

Children with ASD who are ready for a subject to be understood may fail simply because they are feeling panicky and upset by classroom noise, bright windows or rapid movement, for example, Gustavson says, or even crossed or swinging legs can create too much stimulation for them to learn. The milder medications will reduce anxiety, rather than overstimulate.

The younger a child with ASD receives appropriate intervention through therapy, as well as classroom and home environment adjustments, the better it will be for the child and the family.

They need to be identified early on, and the main thing we can do for all of them is reduce the stimulation and have them hear language in a calm way.

Dr. Gustavson warns that screens are not good for children, but they have especially negative effects on children with ASD. Recent studies of 6- to 9-month-old infants in Europe show that some babies will not focus on a virtual face as normal babies do.

There are 100 times the bites in Sponge Bob as in Mr. Rogers, Gustavson says. That screen is more confusing to the child than hammering on a simple, old-fashioned toy.

Dr. Gustavson says he teaches parents how to talk to their child and how to manage their child.

Communication is what were fostering, he says. Im helping the mother communicate with her child, giving them opportunities to get better, and to help the mother and father learn to get better, to learn how to communicate with their unique child.

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The Autistic Brain and Early Intervention - tulsakids.com

Can You Become Reinfected With Covid? It’s Very Unlikely, Experts Say – The New York Times

Megan Kent, 37, a medical speech pathologist who lives just outside Boston, first tested positive for the virus on March 30, after her boyfriend became ill. She couldnt smell or taste anything, she recalled, but otherwise felt fine. After a 14-day quarantine, she went back to work at Melrose Wakefield Hospital and also helped out at a nursing home.

On May 8, Ms. Kent suddenly felt ill. I felt like a Mack truck hit me, she said. She slept the whole weekend and went to the hospital on Monday, convinced she had mononucleosis. The next day she tested positive for the coronavirus again. She was unwell for nearly a month, and has since learned she has antibodies.

This time around was a hundred times worse, she said. Was I reinfected?

There are other, more plausible explanations for what Ms. Kent experienced, experts said. Im not saying it cant happen. But from what Ive seen so far, that would be an uncommon phenomenon, said Dr. Peter Hotez, the dean of the National School of Tropical Medicine at Baylor College of Medicine.

Ms. Kent may not have fully recovered, even though she felt better, for example. The virus may have secreted itself into certain parts of the body as the Ebola virus is known to do and then resurfaced. She did not get tested between the two positives, but even if she had, faulty tests and low viral levels can produce a false negative.

Given these more likely scenarios, Dr. Mina had choice words for the physicians who caused the panic over reports of reinfections. This is so bad, people have lost their minds, he said. Its just sensationalist click bait.

In the early weeks of the pandemic, some people in China, Japan and South Korea tested positive twice, sparking similar fears.

South Koreas Centers for Disease Control and Prevention investigated 285 of those cases, and found that several of the second positives came two months after the first, and in one case 82 days later. Nearly half of the people had symptoms at the second test. But the researchers were unable to grow live virus from any of the samples, and the infected people hadnt spread the virus to others.

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Can You Become Reinfected With Covid? It's Very Unlikely, Experts Say - The New York Times

Tip of the Iceberg: The Oral-Overall Health Link – UConn Today

This story originally appeared in UConn Health Journal.

When youre sick, you go to the physician. When you have tooth troubles, you see your dentist. You dont expect the dentist to diagnose you with the flu, or your primary care provider to treat your teeth.

In reality, the divide is not so clear cut. Dentists might not make the diagnosis, but they can be the first to detect an illness in a patient when they notice swollen gums, sores, and lesions that can signal that the body is fighting a disease beyond the mouth.

Whats more, brushing your teeth twice a day wont just give you a dazzling smile study after study has shown that maintaining excellent oral health is critical to staying healthy, especially in older patients.

This link drives the interprofessional nature of the education and research at the UConn School of Dental Medicine, part of a growing trend to better prepare every member of the health care team to treat the overall health of the patient as part of an interdisciplinary collaboration.

What Lies Beneath

At UConn Health, this comprehensive education begins at the start of dental and medical school. Students from both schools participate in a shared biomedical sciences curriculum during their first 16 months.

The curriculum at UConn Health is very special, says Dr. Douglas Peterson, professor of oral medicine and a lead faculty member for the interprofessional curriculum. It capitalizes upon high quality basic and clinical science, and positions students and faculty from UConn professional schools to continue to learn how best to treat a medically complex patient based upon the highest quality scientific evidence.

Interprofessional health care is vital to meeting the challenges of health care today. It requires the entire health care team including but not limited to dentists, physicians, nurses, pharmacists, and social workers to collaborate to provide safe and effective treatment. For School of Dental Medicine students, this concept is taught both in the classroom and in the clinics.

From the dental medicine perspective, our faculty works with dental students in lectures, seminars, and clinical settings throughout the four year curriculum to continually highlight the scientific and clinical relationships between oral and systemic health and disease, says Peterson.

To that end, dental students are trained to notice the ways certain systemic diseases manifest in the mouth. Dentists are often the first line of defense, able to perform testing to either rule out the suspected underlying cause or refer patients to their physicians for further evaluation and treatment when needed.

The interface between oral health and disease and systemic health and disease is centrally important, says Peterson. We teach the dental and medical students that, if we detect an oral disorder for which the cause cannot be completely attributed to oral factors, we then need to think about the possibility of a systemic relationship to the oral condition.

In one prevalent example, dentists have become increasingly instrumental in detecting untreated diabetes. More than 21 percent of the 34.2 million people in the U.S. with diabetes were not aware of or did not report having the disease, according to 2020 Centers for Disease Control and Prevention data.

The relationship between diabetes and periodontal disease is one of the best-studied connections between an underlying medical condition and its oral manifestation, says Dr. Rajesh V. Lalla, UConn School of Dental Medicine professor and associate dean for research.

The common and preventable gum disease periodontitis manifests as red, swollen, bleeding gums. A dentist who suspects poor hygiene is not the culprit could test a patients blood glucose level to screen them for untreated type 1 or type 2 diabetes.

In 2018, general dentistry residents at UConn Health began a pilot study to assess the feasibility and impact of implementing a diabetes screening protocol in UConns dental clinics. Patients deemed at risk were offered chairside HbA1C testing, which measures average blood glucose levels over a three-month period.

Nearly 60% of patients tested were found to be in the pre-diabetic range and received referral to primary care for diagnosis and treatment. Early intervention with prediabetic patients has been shown to cut the risk of developing type 2 diabetes in half.

Dentists might also be the first to notice symptoms of HIV or cancer. Oral candidiasis, an oral fungal infection that may signify a weakened immune system, was one of the first diagnostic signs of HIV when the epidemic started in the early 1980s, according to Dr. Anna Dongari-Bagtzoglou, professor and head of the department of oral health and diagnostic sciences at the School, who has been studying oral candidiasis for over two decades.

An unusual lesion or sore detected during a routine check-up could trigger screenings and a biopsy, as it could mean oral cancer.

It is important to be evaluated by a dental professional on a regular basis. If a potentially serious mouth condition is developing, early diagnosis and treatment is key, says Peterson. Our dental students graduate from UConn knowing that considering the patients overall health rather than just whats going on in their mouth could make a big difference in a patients health and well-being.

Two-Way Street

On the flip side, UConn Health researchers also contribute to the growing body of evidence that shows keeping your mouth healthy helps keep the rest of you healthy.

Large-scale studies published by the American Heart Association and American Academy of Periodontology have shown that patients with poor oral hygiene have been found to be at increased risk of heart attack, heart failure, stroke, and respiratory disease.

A recent paper published in the Journal of the American Geriatrics Society by Dr. Patrick Coll, professor of family medicine and medicine at the UConn School of Medicine, with UConn School of Dental Medicine faculty coauthors, examined the links between poor oral hygiene, oral infection, and systemic infection in older patients. It also emphasized the importance of health care providers of all types encouraging proper hygiene.

Bacteria in the oral cavity being released in the bloodstream can have detrimental effects on older patients with replacement heart valves and prosthetic joints, for one. The bacteria can potentially lead to infections in the area of the implant. If you have an artificial heart valve, you need to be particularly fastidious with your oral hygiene, says Coll.

Poor oral health and aging can also lead to tooth loss, affecting a persons ability to chew, potentially leading to malnutrition.

Coll and his coauthors recommend eldercare facilities adopt interventions to help combat the barriers older populations face in receiving proper oral care. Patients with dementia may neglect their oral health and be reluctant to see a dental hygienist, for example, and nursing home residents often receive inadequate care despite federal requirements, the UConn experts say. Medicare doesnt currently cover dental care, making it difficult for low-income seniors to see a dentist.

Nursing homes should adopt risk assessment tools to identify patients at high risk for poor oral hygiene and should educate staff on the importance of good oral hygiene and how to provide it, they write.

There are many aspects to promoting healthy aging, and oral health is an important piece, Coll says.

Coll says he and the rest of the interprofessional health care team at UConn are committed to providing the very best health care, including oral care, based on the latest research and clinical evidence.

The overall goal of this line of health care is centered in the UConn Health mission to achieve and maintain patient wellness, says Peterson.

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Tip of the Iceberg: The Oral-Overall Health Link - UConn Today

What Is It That Keeps Most Little Kids From Getting Covid-19? – The New York Times

For starters, rather than prohibiting children from playing together and eliminating all social risk, Dr. Chiang and the A.A.P. schools-reopening guidelines focus on reducing risk and state that outdoor play is safer than indoor play. Jenkins said her family now socializes with another cautious family. Their summer plans include outdoor playground and beach visits, but not museums.

Some families who initially tried going without sitters and nannies have relented, and public-health experts acknowledge that the strain was significant. Parents and nannies should have honest discussions about their expectations for mask-wearing and distancing. But there is no way for a nanny to socially distance from a young kid shes taking care of, Dr. Chiang said. And there is no evidence that risk of transmission is lower for a younger nanny, she added.

Ultimately, parents have to weigh their threshold for risk when it comes to childrens interactions with others. And that same advice applies to day care, summer camp or school in the fall. Parents should consider the demands of their work, whether any household member is at high risk for severe Covid-19, the status of the outbreak in their community and administrators plans for keeping children and staffers at least in fixed and distanced groups. Also, look for policies requiring children and staffers to be screened for symptoms.

In other words, Dr. Chiang said, if the spread of coronavirus in your community is low, if administrators seem to be taking risk reduction seriously and if parents have to work from home or are essential workers, sending young kids to day care or school may make sense.

The logistics of keeping kids out of school, but still trying to educate them, go far beyond just infectious diseases, Dr. Starke. They go into economics, they go into social structure, and they go into families.

Dr. Chiang has the same decisions to make. When her daughters day care reopened, she spoke with the facilitys director about distancing, disinfection and other coronavirus-related policies. Statistics, family composition, and the age of her daughter also must be considered.

With her being 2 1/2, the risk that shes going to have severe disease from Covid-19 or develop MIS-C is tiny, Dr. Chiang said. We dont have any older family members living with us or in town, so we dont have to consider her getting infected at day care and infecting grandma and grandpa. And the benefits she gets from day care are amazing.

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What Is It That Keeps Most Little Kids From Getting Covid-19? - The New York Times

Pre-med students weigh their health with their future, as COVID-19 spikes – Oregon Daily Emerald

Normally, medical students have a clear path through school four years of college, four years of medical school and then residency. The coronavirus disrupted this process on many levels. Nationally, and at the University of Oregon, students are finding it hard, or nearly impossible, to meet the high standards medical school sets for them.

The challenges these students have faced led some students to form a group called the Students for Ethical Admission. The group created an in-depth document that outlined the issues approximately 200 surveyed students experienced, and suggested three changes to the Association of American Medical Colleges: waiving the Medical College Admission Test for this admissions cycle, delaying the application and having the association commit to clearer communication and transparency with pre-medical students.

One of the largest issues is the MCAT. The MCAT is a standard test for pre-medical students, and is required by most colleges like the Oregon Health & Science University and Western University of Health Sciences, even under the current conditions. The AAMC is still holding the tests in brick-and-mortar testing sites. Allowing online testing would be jeopardizing the integrity and fairness of the test, according to a letter from the AAMC.

The MCAT is a grueling test, and some students pay for tutoring and practice. For students who don't come from families with the financial means to support them, this test is a huge investment in their future one that could be completely wasted if test times are changed or cancelled, according to Rachel Lutz, a pre-medical biochemistry major at UO.

Its devastating to give up a year of your time, but for many students, its the money, Lutz said. When you give up a year, you give up thousands of dollars of prep.

Lutz is concerned that this change would bar many people of color of poor backgrounds from entering into the medical field, creating an entire generation of doctors that are mostly White.

For Lutz, one of the largest problems shes faced is sending and receiving transcripts. Usually an easy process, the UO application system is all paper nothing digital and it's slowed down to a crawl, she said. Medical schools are on a rolling application-based system, meaning that the later students apply, the less likely schools will see their applications.

"I don't know exactly what's going on there, but the implications have been that they do not pick up the phone and they're overburdened in their email inbox. This has resulted in me emailing them over 10 times," she said. "It's resulted in at least two of my transcripts being sent to my med school applications that were missing key addendums."

Sahara Kumaran is also a pre-med student, and said her biggest issue is that she is unable to get the same experience online that she would get in a lab.

"A lot of classes are online right now, and that's okay if its a lecture class. But for lab-based classes, it's much harder to learn those same skills online," Kumaran said. "Part of those lab classes is actually physically doing the experiments yourself, so its much more difficult."

I feel like Im being left behind. I feel like our peers are being left behind, Lutz said, I think its really hard and I think a lot of applicants feel alone right now.

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Pre-med students weigh their health with their future, as COVID-19 spikes - Oregon Daily Emerald

Common Blood Test Identifies Benefits and Risks of Steroid Treatment in COVID-19 Patients – BioSpace

Research from Albert Einstein College of Medicine and Montefiore Builds on Large British Study

BRONX, N.Y., July 22, 2020 /PRNewswire/ -- A new study led by Albert Einstein College of Medicine and Montefiore Health System confirms the findings of the large scale British trial of steroid use for COVID-19 patients and advances the research by answering several key questions: Which patients are most likely to benefit from steroid therapy? Could some of them be harmed? Can other formulations of steroids substitute for the agent studied in the British trial? The research was published today in the Journal of Hospital Medicine.

The U.K. RECOVERY trial, a prospective, randomized, open-label study of the steroid dexamethasone versus standard of care, involved more than 6,000 patients with COVID-19. Dexamethasone reduced deaths by about one-third in patients on ventilators and by about one-fifth among people who needed oxygen but were not on ventilators. However, the study leaves questions about the use of steroids for treating some patients.

"Our study is consistent with the promising findings from Britain, but for the first time, we are able to demonstrate that people can see the same life-saving benefits with steroid formulations other than dexamethasone," said Marla Keller, M.D., vice chair for research in the department of medicine at Einstein and Montefiore and lead author of the study. "We also found that a common blood test may identify the best candidates for steroid treatment." Dr. Keller is also professor of medicine and of obstetrics & gynecology and women's health at Einstein and an infectious disease specialist at Montefiore.

Authors of the Einstein-Montefiore study compared outcomes for two groups selected from nearly 3,000 people hospitalized at Montefiore with a positive COVID-19 test. One group of 140 patients was treated with steroids within 48 hours of hospital admission; and a control group of 1,666 similar patients did not receive steroid therapy. Most of the patients who received steroid therapy received prednisone. Some received dexamethasone and methylprednisolone.

Nearly all patients initially had a blood test to measure levels of C-reactive protein (CRP), which the liver produces in response to inflammation. The higher the CRP level in the blood, the greater amount of inflammation. A normal CRP level reported in the study is below 0.8 milligrams per deciliter of blood.

"We found that in patients with high levels of inflammation, namely a CRP level greater than 20, steroids were associated with a 75% reduction in the risk of going on mechanical ventilation or dying," said Dr. Keller. "Critically, we also found that for patients with a lower level of inflammation CRP levels less than 10 steroid use was associated with an almost 200% increased risk of going on mechanical ventilation or death."

A large percent of the people who succumb to COVID-19 die from the body's intense inflammatory response, which can overwhelm and severely damage the lungs. "Our findings suggest that steroid therapy should be reserved for people with high inflammation, as indicated by markedly elevated CRP levels," said William Southern, M.D., M.S., professor of medicine and chief of the division of hospital medicine at Einstein and Montefiore and the study's senior author. "It's a different story for people who do not have significant inflammation: for them, any benefit is outweighed by the risks from using steroids."

Study co-author Shitij Arora, M.D., associate professor of medicine at Einstein and a hospitalist at Montefiore, noted that the Einstein-Montefiore study included approximately equal numbers of male and female patients. In addition, nearly 40% of patients studied were Black and 36% were Hispanic. "The demographic diversity of the patients in this study suggests that steroid therapy benefits hospitalized COVID-19 patients affected by significant inflammation regardless of their race or ethnicity," he said.

The title of this paper is "Effect of Systemic Glucocorticoids on Mortality or Mechanical Ventilation in Patients With COVID-19." Other Einstein and Montefiore authors were Jen-Ting Chen, M.D., M.S., Elizabeth Kitsis, M.D., M.B.E., Shivani Agarwal, M.D., M.P.H., Michael Ross, M.D., and Yaron Tomer, M.D.

About Albert Einstein College of MedicineAlbert Einstein College of Medicine is one of the nation's premier centers for research, medical education and clinical investigation. During the 2019-20 academic year, Einstein is home to 724 M.D. students, 158 Ph.D. students, 106 students in the combined M.D./Ph.D. program, and 265 postdoctoral research fellows. The College of Medicine has more than 1,800 full-time faculty members located on the main campus and at its clinical affiliates. In 2019, Einstein received more than $178 million in awards from the National Institutes of Health (NIH). This includes the funding of major research centers at Einstein in aging, intellectual development disorders, diabetes, cancer, clinical and translational research, liver disease, and AIDS. Other areas where the College of Medicine is concentrating its efforts include developmental brain research, neuroscience, cardiac disease, and initiatives to reduce and eliminate ethnic and racial health disparities. Its partnership with Montefiore, the University Hospital and academic medical center for Einstein, advances clinical and translational research to accelerate the pace at which new discoveries become the treatments and therapies that benefit patients. Einstein runs one of the largest residency and fellowship training programs in the medical and dental professions in the United States through Montefiore and an affiliation network involving hospitals and medical centers in the Bronx, Brooklyn and on Long Island. For more information, please visit http://www.einstein.yu.edu, read our blog, follow us on Twitter, like us on Facebook, and view us on YouTube.

About Montefiore Health SystemMontefiore Health System is one of New York's premier academic health systems and is a recognized leader in providing exceptional quality and personalized, accountable care to approximately three million people in communities across the Bronx, Westchester and the Hudson Valley. It is comprised of 10 hospitals, including the Children's Hospital at Montefiore, Burke Rehabilitation Hospital and close to 200 outpatient care sites. The advanced clinical and translational research at its' medical school, Albert Einstein College of Medicine, directly informs patient care and improves outcomes. From the Montefiore-Einstein Centers of Excellence in cancer, cardiology and vascular care, pediatrics, and transplantation, to its' preeminent school-based health program, Montefiore is a fully integrated healthcare delivery system providing coordinated, comprehensive care to patients and their families. For more information please visit http://www.montefiore.org. Follow us on Twitter and view us on Facebook and YouTube.

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Common Blood Test Identifies Benefits and Risks of Steroid Treatment in COVID-19 Patients - BioSpace

A closer look at the programs excluded from the 2020-21 tuition freeze – Minnesota Daily

As a result of the COVID-19 pandemic, President Joan Gabel froze tuition for students at the University of Minnesota for the 2020-21 academic year.

Under this decision, approved by the Board of Regents in April, all students will pay the same tuition rates as the 2019-20 academic year. However, this announcement excluded three programs within the University, including the Medical School, the School of Dentistry and several graduate degrees in the College of Science and Engineering.

College of Science and Engineering

The Technological Leadership Institute within CSE offers specialized degrees for graduate and professional students focusing on technology and business. Due to the unique nature of these degrees, they were not included in the tuition freeze.

Within this program, each incoming class of students enters into cohorts, where they pay a fixed tuition rate for the entirety of their time in the program.

The important thing to note is the tuition is fixed for the cohort. For example, the group that starts this year will graduate at the end the spring of 2022 and their tuition will be the same, said Douglas Ernie, interim director of TLI.

The programs included in the institute include the areas of medical device innovation, management of technology and security technologies.

Additionally, this program does not receive outside financial contributions and is completely funded by student tuition.

We are a financially self-supporting unit ... we don't get any budget lines from the state in that sense for staffing or any faculty or anything, Ernie said. Based on that, and based on analysis of similar programs across the country and based on program demand, that's how we set our tuition rate.

The increase in tuition for next year ranges from between $800 and $3,600 total, Ernie said.

School of Dentistry

The Universitys School of Dentistry students will also not receive a tuition freeze for the 2020-21 academic year, although exceptions are being made for the cohort of students entering their final year in the Doctor of Dental Surgery and Dental Therapy programs.

Class of 2021 students in these programs have endured unique challenges this past semester and will experience more during their graduating year. Freezing tuition for these cohorts takes these challenges into account, read an emailed statement from the School of Dentistry to the Minnesota Daily.

The tuition for other students in these programs will be increased by 2% to account for educational and administrative costs of the program and a decrease in clinical visits.

This [2%] increase is in alignment with the market need for dentists, comparable or slightly below increases being proposed at Big Ten peer institutions. The School continues to make available to students internal scholarships to assist with tuition and other costs, the statement reads.

The Medical School

The Universitys Medical School is the final program not included in the academic tuition freeze.

The school operates under a "cost of degree" model, where tuition is held flat for four years with each incoming class.

We have held tuition flat for four years in order to align with the mid-range tuition of our peers and that is where we remain, read an emailed statement from the University of Minnesota Medical School to the Minnesota Daily.

This program also experiences unique educational costs associated with COVID-19 and the demand of the degrees offered.

In order to protect our students and patients, we have a significant need for more safety equipment, simulation, smaller classes, additional health and well-being programming, and student services required for accreditation, the statement read.

Student response

Students within the College of Science and Engineering generally did not respond negatively to the tuition freeze due to their unique circumstances as students, Ernie said.

Many of these students are also working full time and receive tuition reimbursement. Additionally, the program is transparent about the continuity of their program cost, he said.

We advertise our rates when we are starting our recruiting cycle in fall the year before, Ernie said. So they're not getting an increase every year the rate that they come in at is the rate until they finish.

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A closer look at the programs excluded from the 2020-21 tuition freeze - Minnesota Daily

Geriatric psychiatry and COVID-19: Interview with Dr. Ali Abbas Asghar-Ali – Baylor College of Medicine News

Editors note: This is the first in a series of Progress Notes posts featuring mental health professionals, their interests, and their thoughts on the COVID-19 pandemic.

Dr. Ali Abbas Asghar-Ali is a geriatric psychiatrist and currently serves as the geriatric psychiatric fellowship director at Baylor College of Medicine. He is also dedicated to enhancing the cultural attunement of clinicians to best serve all patients.

I have been fortunate enough to engage and receive professional guidance from Dr. Asghar-Ali, who also serves as the faculty advisor for PsychMinded, the student organization leading this interview series.

Dr. Asghar-Ali shares his professional journey and how he has been coping during these uncertain times.

It wasnt until late in my third year in medical school that I decided I would like to pursue psychiatry. When I started medical school, I saw myself becoming an internist. During my rotation in psychiatry, I recognized how much I enjoyed learning about peoples emotional health and working with individuals and the environments in which they exist. It was only then that I realized I had an interest in psychological constructs and community structures.

I took as many sociology and psychology courses as I could as a science major. In medical school, I never missed a psychiatry interest group meeting (while I was vice president of the internal medicine interest group!)

I am a geriatric psychiatrist, which requires a one-year fellowship after completion of a general psychiatry residency. Since completing my training, I have been at the VA, which is an ideal clinical setting for a geriatric practitioner and offers tremendous opportunities to develop an educational and research career.

For eight years I was an inpatient geriatric psychiatrist. However, for the last five years my time has been split between electroconvulsive therapy and educational efforts at the South Central Mental Illness Research, Education, and Clinical Center.

The field has a lot to offer and can be extremely gratifying. There are a tremendous number of facets to psychiatry, ranging from psychoanalytic therapy to deep brain stimulation. Though stigma persists, there is change afoot with an increasing emphasis on mental wellness and seeking care if needed, making this an ideal time to become a psychiatrist.

Geriatric psychiatry is a remarkably interdisciplinary sub-specialty. Older adults can have highly complex conditions and needs, and often no one discipline can fully address these needs. Depending on the setting, e.g., an acute inpatient unit, the psychiatrist may be the team lead. In such a circumstance, their role would include diagnosis and directing the treatment plan. Within treatment planning, they would be considered the expert in psychiatric medication management.

However, it is critical that psychiatrists have a biopsychosocial understanding of the persons condition and develop a treatment plan that acknowledges and strives to address each issue. While the psychiatrist may not be the expert in social interventions, they must be knowledgeable about resources that could be utilized and incorporate them into treatment planning.

Shared responsibility and humility are important when working in an interdisciplinary team. Its essential that all team members have an opportunity to voice their understanding and recommendations. In geriatric psychiatry, the team often also includes an occupational therapist/physical therapist, caregivers, and a geriatrician. Specialists such as neurologists, speech pathologists, PM&R specialists, may also interface with the team.

I feel very fortunate that I have been able to continue my work with little disruption we are able to offer ECT at the VA to those who need it, and I continue to develop scholarly projects. I work with wonderful colleagues who are supportive.

Of course, I have been spending much more time at home and I again feel fortunate to have a comfortable home in which my mother, children, wife, and I can all have our own space. As a family, we have undoubtedly grown closer. Ramadan was especially meaningful as we practiced all our observances together with minimal distractions. I have been taking more time to sleep and ensuring that physical activity does not disappear from my life.

Paying attention to mental health and physical health before there are problems is important Were often taught to brush things under the carpet, to push through. However, its important to take time to develop personal resources to manage day-to-day life, then employ these resources when stressors occur.

We have developed a Wellness Guide for Veterans that highlights tools to maintain wellness, I also read a wonderful article that highlights the usefulness of laughter and how to harness it in a very deliberate manner.

I am also a great believer in interdependence. Working as a collective, whether its with colleagues, friends, family, or healthcare professionals not only builds bonds, but also allows us to maximize our resources.

-By Jessica C. Sheu, third-year medical student at Baylor College of Medicine

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Geriatric psychiatry and COVID-19: Interview with Dr. Ali Abbas Asghar-Ali - Baylor College of Medicine News

Citius Pharmaceuticals Forms Scientific Advisory Board for the Planned Development of its Proprietary Treatment for Acute Respiratory Disease…

CRANFORD, N.J., July 22, 2020 /PRNewswire/ --Citius Pharmaceuticals, Inc.("CITIUS") ("Company") (NASDAQ:CTXR), a specialty pharmaceutical companyfocused on developing and commercializing critical care drug products, announced today the formation of the Citius ARDS (Acute Respiratory Distress Syndrome) Scientific Advisory Board to provide the company expert guidance on its planned development of induced mesenchymal stem cells (iMSCs) under option from Novellus, Inc. to treat and reduce the severity of acute respiratory distress syndrome (ARDS) associated with COVID -19.

The ARDS Advisory Board consultants are:Michael A. Matthay, MD, Professor of Medicine and Anesthesia at the University of California at San Francisco (UCSF), a Senior Associate at the Cardiovascular Research Institute, and Associate Director of the Critical Care Medicine at UCSF. Dr. Matthay's basic research has focused on the pathogenesis and resolution of the acute respiratory distress syndrome (ARDS), with an emphasis on translational work and patient-based research, including clinical trials. Dr. Matthay's recent research has focused on the biology and potential clinical use of allogeneic bone marrow derived mesenchymal stromal cells (MSCs) for ARDS. He is currently leading the "Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (STAT)," a United States Department of Defense supported study of MSCs for ARDS.

Mitchell M. Levy, MD, Chief, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, The Warren Alpert Medical School of Brown University, where he is Professor of Medicine. Dr. Levy also serves as Medical Director of the Medical ICU at Rhode Island Hospital. He has been an investigator on numerous pharmacologic and biologic trials intended to treat sepsis, cardiovascular and pulmonary pathology. He has expertise in trial design, clinical trial execution and trial management and is one of the three founding members of the Surviving Sepsis Campaign (SSC). Dr. Levy is Past-President of the Society of Critical Care Medicine (2009).

Lorraine B. Ware, MD, Professor of Medicine and Ralph and Lulu Owen Endowed Chair,Professor of Pathology, Microbiology and Immunology, Vanderbilt University;Director, Vanderbilt Medical Scholars Program. Dr. Lorraine Ware's comprehensive bench-to-bedside research program centers on the pathogenesis and treatment of sepsis and acute lung injury with a current focus on mechanisms of lung epithelial and endothelial oxidative injury by cell-free hemoglobin. Dr. Ware is also a lead investigator for the "Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (STAT)" study.

"We are extremely pleased to have been able to attract such a prestigious group of experts to advise and guide us in the Company's planned development of iMSC's for the treatment of ARDS" said Mr. Myron Holubiak, CEO of Citius. "These individuals are recognized opinion leaders and expert in the planning and execution of clinical trials in this therapeutic area. We will be seeking their advice in all phases of our clinical trial design."

About Citius Pharmaceuticals, Inc.Citius is a late-stage specialty pharmaceutical company dedicated to the development and commercialization of critical care products, with a focus on anti-infectives and cancer care. For more information, please visit http://www.citiuspharma.com.

About Citius iMSCCitius's planned induced mesenchymal stem cell (iMSC) product is derived from a human induced pluripotent stem cell (iPSC) line generated using a proprietary non-immunogenic and non-viral mRNA-based (non-viral) reprogramming process. Unlike the MSCs derived from bone marrow, placenta, umbilical cord, or adipose tissue these proprietary iMSCs are based on a clonal process and therefore are genetically homogeneous and exhibit superior potency and higher cell viability. The Citius iMSC is an allogeneic (unrelated donor) mesenchymal stem-cell product manufactured by expanding material from an iMSC master cell bank. The master cell bank produces "off-the-shelf" iMSCs that are uniform as compared to MSCs using donor-sourced cells, which is subject to batch-to-batch and cell-to-cell variability that can affect clinical safety and efficacy. In vitro studies demonstrate that iMSCs are shown to secrete higher levels of immunomodulatory proteins than donor-derived cells, and may reduce or prevent pulmonary injury associated with acute respiratory distress syndrome (ARDS) in patients with COVID-19.

About Acute Respiratory Distress Syndrome (ARDS)ARDS is a type of respiratory failure characterized by rapid onset of widespread inflammation in the lungs. ARDS is a rapidly progressive disease that occurs in critically ill patients most notably now in those diagnosed with COVID-19. ARDS affects approximately 200,000 patients per year in the U.S., exclusive of the current COVID-19 pandemic, and has a 30% to 50% mortality rate. ARDS is sometimes initially diagnosed as pneumonia or pulmonary edema (fluid in the lungs from heart disease). Symptoms of ARDS include shortness of breath, rapid breathing and heart rate, chest pain (particularly while inhaling), and bluish skin coloration. Among those who survive ARDS, a decreased quality of life is relatively common.

Safe HarborThis press release may contain "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such statements are made based on our expectations and beliefs concerning future events impacting Citius. You can identify these statements by the fact that they use words such as "will," "anticipate," "estimate," "expect," "should," and "may" and other words and terms of similar meaning or use of future dates. Forward-looking statements are based on management's current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition and stock price.

Factors that could cause actual results to differ materially from those currently anticipated are: the risk of successfully negotiating within the option period a license agreement with Novellus, Inc. for our planned iMSCs therapy for ARDS; our need for substantial additional funds; risks associated with conducting clinical trials and drug development; the estimated markets for our product candidates and the acceptance thereof by any market; risks related to our growth strategy; risks relating to the results of research and development activities; uncertainties relating to preclinical and clinical testing; the early stage of products under development; our ability to obtain, perform under and maintain financing and strategic agreements and relationships; our ability to identify, acquire, close and integrate product candidates and companies successfully and on a timely basis; our dependence on third-party suppliers; our ability to attract, integrate, and retain key personnel; government regulation; patent and intellectual property matters; competition; as well as other risks described in our SEC filings. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as required by law.

Contact:Andrew ScottVice President, Corporate Development(O) 908-967-6677 x105ascott@citiuspharma.com

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Citius Pharmaceuticals Forms Scientific Advisory Board for the Planned Development of its Proprietary Treatment for Acute Respiratory Disease...

For Black Scientists, the Sorrow Is Also Personal – Duke Today

I have tried to live in a world that does not see color but have only succeeded in living in a world that does not see me.

I am a medical doctor and a scientist; the first African American awarded a PhD in neuroscience at Duke University. I have led a National Institutes of Health-funded research lab for almost a decade, and I was awarded the Society for Neuroscience Young Investigator Prize in 2019. I am an American Association for the Advancement of Science Alan I. Leshner Public Engagement Fellow, and I have hosted TEDMED three times.

I am a scholar, teacher, mentor, speaker, and mental health advocate. I have served on national commissions, I have advanced federal policy, and I have even held court with a president of the United States. I have published in Cell scientific journals, and as a peer reviewer, I have worked to advance the scientific rigor of my colleagues. Yet, most days, I am unseen and unknown. As I watched a knee slowly, mercilessly, and inhumanly extinguish yet another black life, I was overwhelmed by anger and sorrow, and at this very moment, I am terrified to run on the trail near my home. I am a black academic in America.

Academia is the space where evidence is created, explored, and shared. I started medical school 20 years ago full of the belief that everyone was equal and that scientific evidence was fair, unbiased, and always reflected the truth. Yet, I was soon confronted by overwhelming images of black men in my textbooks who all had advanced-staged sexually transmitted diseases. Surely it wasnt only black men that get STDs? These subtexts about race and health infected many of the narratives that accompanied daily morning rounds in the hospital. One day, it became strikingly clear that the academic system was subtly advancing an insidious idea that everyone was not indeed equal.

As I grew as a scientist, I began to recognize the profound consequences of this insidious framework. I learned that blacks were underrepresented in the clinical trials used to achieve FDA approval for many commonly prescribed medications. How could any well-reasoned scholar then argue that these medications worked as well for black patients? Even the large-scale genomic studies I read in the world-leading scientific journals as a physician-scientist trainee did not extrapolate to blacks. Did black lives even matter with regards to the equitable development and distribution of medical interventions? Every corner of the academic system seemed to suggest that they did not, and there were few black academics to generate alternative evidence to confront this insidiously biased framework. Even now, only 12 percent of scientists awarded major grants by the National Institutes of Health are black. Painfully, scientific evidence also suggests that even after accounting for training institutions, publication records, and major awards, the review system used to select winners for these research grants is biased against blacks.

While these systematic realities each take their emotional and intellectual toll, my personal experiences as a black academic in America have been much more scarring. There was the time a well-meaning individual called the police to report a black man soliciting in my friends neighborhood. The squad car arrived as I was walking toward my friends house from a nearby pond; my Danskos, scrubs, white coat, Duke medical school ID badge, and the oversized anatomy book in my hand were not sufficient evidence to bypass their 20 minute inquisition.

Every meeting is my protest. Every protest is exhausting. There is a price that I pay every single day.-- Dr. Kafui Dzirasa

There was the first time that I was invited to give a keynote lecture at a major international conference. While I stood in the hotel lobby with my colleagues, a woman walked through the crowd and handed me her suitcase. I was the only black face in sight. Then, there are the endless occasions where colleagues who always say hi when I am wearing my white coat either dont recognize me when I wave or even make eye contact with me when I am wearing sweatpants (my preferred outfit in the lab).

The most embarrassing experience was when I went to grab a slice of pizza at my department lunch after a student seminar. A staff member quickly approached and asked me who I work for (myself) and then whose lab I was in (my own) as if I had not understood the question, though we were literally standing in the same research building that Ive spent the vast majority of my time in as a graduate student, postdoctoral researcher, clinical resident, and faculty over the last 20 years. I responded in the same way I always do. I hid myself and answered with a smile. I am a black man, and the idea of making people feel uncomfortable about my presence always feels like career suicide.

Since then, Ive sat in far too many meetings where there are no faces that look like mine. The pipeline doesnt existits impossible to recruit talented black people, they say. And so, I choose to quietly protest this entire academic system with my excellence. I held my protests at Duke, MIT, Harvard, Johns Hopkins, WashU, UPenn, Yale, Weill Cornell, Mt. Sinai School of Medicine, Stanford, UCSF, Columbia, UVA, University of Rochester, Tufts, University of Maryland School of Medicine, UT Southwestern, Baylor, NYU, University of Chicago, Northwestern, UIC, UT San Antonio, UNC, NC State, Brown, University of Buffalo, Ohio State, University of Minnesota, UCSD, UCLA, University of Colorado Anschultz, Cal Tech, National Institutes of Health, Woods Hole, Einstein, and the University of Florida. For the few black trainees in the audience, it is the first time that they see a face that looks like theirs at the podium. I prepare endlessly to become the best because my excellence gives these trainees hope.

I must outwork this system. I must outlast this system. I must be scientifically sound and full of wit. Its the only way to have impact. I must be endlessly optimistic. Its the only way to endure the unceasing environmental cues that scream I dont belong. I bear the full weight of my experiences, my perspectives, and my community as I work tirelessly to advance the biomedical research enterprise and the mental health of all Americans.

Every meeting is my protest. Every protest is exhausting. There is a price that I pay every single day. I accept this unfathomablepersonal cost to create new evidence and to counterbalance insidious historical untruths.

I also bear the shared experiences of the many young scientists that I mentor. We are all tired, and we have been crippled by the weight of these chronic and acute experiences. And yet, we all continue to yearn and desperately hope for a day when AllLivesMatter. This was Martin Luther King Jr.s dream, the self-evident promise whispered at our precious Americas inception. We are drowning in sorrow.

Yet, we are also overbrimming with hope as our beloved America finally awakens to the notion that all lives cannot matter until BlackLivesMatter too. We are black academics in America. We too define the truth, and it is time for our colleagues to listen and, in this instance, follow.

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For Black Scientists, the Sorrow Is Also Personal - Duke Today

COVID-19 vaccine trials to be conducted at Washington University, Saint Louis University Washington University – Washington University School of…

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Vaccine trials to enroll about 3,000 area residents

Researchers at Washington University School of Medicine in St. Louis and the Saint Louis University Center for Vaccine Development have joined the effort to find a COVID-19 vaccine that can prevent the illness. Researchers at the universities expect to enroll about 3,000 participants in several COVID-19 vaccine trials, with each school participating in different trials.

As U.S. scientists ramp up a national effort to evaluate COVID-19 vaccine candidates at clinical trial sites across the country, researchers at Washington University School of Medicine in St. Louis and the Saint Louis University Center for Vaccine Development have been tapped to join the historic effort to find a COVID-19 vaccine that can prevent the illness.

Researchers at the two universities expect to enroll about 3,000 participants in several COVID-19 vaccine trials, with each school participating in different trials.

Researchers say it will be critically important to enroll participants who are likely to be exposed to COVID-19 or those at risk for severe disease from COVID-19, including participants over age 65.

COVID-19 Prevention Network

Washington University and Saint Louis University are participating in the trials as a part of the COVID-19 Prevention Network (CoVPN), a newly organized network formed by the National Institute of Allergy and Infectious Diseases (NIAID) to develop and test vaccines and treatments in the fight against COVID-19.

The COVID-19 Prevention Network will participate in large-scale phase 3 vaccine trials that will enroll thousands of participants from across the U.S. or in some cases around the world to determine whether the vaccines can prevent COVID-19 disease.

The COVID-19 Prevention Network brings together several existing NIH networks, including:

Each of the networks has expertise in conducting clinical trials and is quickly pivoting to evaluate potential COVID-19 vaccines.

Leaders in the Field

Locally, Washington University and Saint Louis University are well positioned to conduct the COVID-19 vaccine trials, due to extensive expertise in infectious disease research.

The Saint Louis University Center for Vaccine Development is home to one of 10 Vaccine and Treatment Evaluation Units in the United States. As such, SLU conducts phases 1 through 4 vaccine and treatment trials, including clinical studies in collaboration with industry partners.

The Center for Vaccine Development at Saint Louis University has 30 years of experience testing novel vaccines and completing urgent pandemic vaccine trials, said Daniel Hoft, MD, PhD, the centers director and principal investigator for the VTEU. We recognize that particularly in these unprecedented times, collaboration is critically important. We look forward to using the collective strengths at SLU and Washington University to get COVID-19 vaccines ready for the U.S. public and world.

Washington University School of Medicine has more than 30 years experience leading clinical trials evaluating new treatments and vaccines for infectious diseases through its Infectious Disease Clinical Research Unit and the AIDS Clinical Trials Group. The latter has been instrumental in conducting trials to control the HIV pandemic, leading to safe and effective medications that treat and prevent HIV infection and AIDS.

Our long history of working with the HIV community has demonstrated how critically important community support is in conducting successful clinical trials, said Rachel Presti, MD, PhD, an associate professor of medicine, director of Washington Universitys Infectious Disease Clinical Research Unit and principal investigator for the AIDS Clinical Trials Group and the HIV Prevention Trials Network. We are excited that the St. Louis community will have this opportunity to participate in historic clinical trials aimed at helping to identify the most effective vaccines for preventing COVID-19.

Partnering with the Community

St. Louisans will be key to the success of the vaccine trials, said Sharon Frey, MD, clinical director of SLUs Center for Vaccine Development and principal investigator of the trial at SLU. A powerful example of the role the St. Louis community plays in advancing public health was seen in the communitys response to the 2009 pandemic influenza vaccine trial. We are deeply grateful for the support of the St. Louis community as we launch these trials, which represent our best hope to fight back against the COVID-19 pandemic.

This is where we begin to really fight back against the scourge of COVID-19, said Washington University lead research coordinator Michael Klebert, PhD, an instructor of medicine. The collaboration of two world-class medical schools with the support of volunteers from the St. Louis community in this effort will be a powerful combination. We are looking forward to the challenge.

Saint Louis University and Washington University will share additional information about the trials as it becomes available.

For more information about vaccine trials at Washington University School of Medicine, please email idcru@wustl.edu; call 314-454-0058 or visit the Division of Infectious Diseases clinical trials site.

For more information about vaccine trials at Saint Louis Universitys Center for Vaccine Development, please visit vaccine.slu.edu; call 314-977-6333 or 1-866-410-6333; or email vaccine@slu.edu.

The Washington University HIV Clinical Trials Unit is supported by the National Institutes of Health (NIH), grant numbers 5UM1AI069439-15 and 3UM1AI069439-15S1.

The Saint Louis University project is funded under cooperative agreement number UM1 AI148685.

Washington University School of Medicines 1,500 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Childrens hospitals. The School of Medicine is a leader in medical research, teaching and patient care, ranking among the top 10 medical schools in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked to BJC HealthCare.

Established in 1836, Saint Louis University School of Medicine has the distinction of awarding the first medical degree west of the Mississippi River. The school educates physicians and biomedical scientists, conducts medical research, and provides health care on a local, national and international level. Research at the school seeks new cures and treatments in five key areas: infectious disease, liver disease, cancer, heart/lung disease, and aging and brain disorders.

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COVID-19 vaccine trials to be conducted at Washington University, Saint Louis University Washington University - Washington University School of...

Different Takes: Gun Violence Is Almost Rivaling The Pandemic; Sacklers Just Might Get Away With Their Fortune Intact – Kaiser Health News

Editorial pages focus on these public health issues and others.

The Washington Post:2020 Is Shattering Gun Violence Records. We Must Act.As the novel coronavirus pandemic continues to ravage the United States, another epidemic is surging: gun violence. Most other types of crime fell during the initial phases of the pandemic, but gun violence increased and mass shootings in particular continue to spiral out of control. There are a lot of crises tugging at the publics attention, but we cannot let this go unresolved. Often when people discuss mass shootings, they focus on the number of people killed, but that overlooks the massive public health and economic toll that nonfatal shootings have on this country. To better take that into account, we define mass shootings as incidents in which four or more people are shot, excluding the shooter. (Devin Hughes, 7/21)

The New York Times:The Sacklers Could Get Away With ItThe billionaire Sacklers who own Purdue Pharma, maker of the OxyContin painkiller that helped fuel Americas opioid epidemic, are among Americas richest families. And if they have their way, the federal court handling Purdues bankruptcy case will help them hold on to their wealth by releasing them from liability for the ravages caused by OxyContin. The July 30 deadline for filing claims in Purdues bankruptcy proceedings potentially implicates not just claims against Purdue, but also claims against the Sacklers. The Sacklers may yet again benefit from expansive powers that bankruptcy courts exercise in complex cases. (Gerald Posner and Ralph Brubaker, 7/22)

Stat:Medical Schools Need To Lower The Cost Of Producing DoctorsMedicine has become a profession accessible mainly to the rich. Just look at the price tag for medical school. In the 1960s, the four years of medical education needed to earn an M.D. in the United States could be had for about $40,000 in todays dollars. The price is now $300,000, a 750% increase. (David A. Asch, Justin Grischkan and Sean Nicholson, 7/21)

Stat:My Patients Want The Good Old Days Of Office VisitsI recently got a note from my secretary with this message from a patient: Tell the doctor I have no interest in a phone call or one of those video visits. When she is back to seeing patients again in the office, let me know. Im hearing that a lot lately from patients who continue to delay routine medical care, not due to fears of Covid-19 but because they yearn for the old face-to-face office visit. (Amy E. Wheeler, 7/22)

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Promoting diversity and inclusion as a medical student at Stanford – Scope

Third-year medical student Claire Rhee decidedto take a stand on issues of social justice long before she chose to pursue a career in medicine.

When she was still in high school in New Jersey, Rheebecame fascinated with the many ways that social context, income level and surroundings can influence a person's health.

After arriving at medical school at Stanford, she became increasingly involved in promoting diversity and inclusion, which led her to serve last year as co-chair of the Stanford University Minority Medical Alliance. SUMMA represents and promotes awareness of issues facing a number of minority groups, including African Americans, Latinx, Asian-Pacific Americans, Muslims, people from indigenous backgrounds, people who identify as LBGTQ+, and people with disabilities or chronic illness.

I caught up with Rhee to discuss her time with SUMMA, diversity and inclusion in health care, and what it means to be an ally.

Why did you get involved in SUMMA?

Being an Asian American, straight-passing woman, I can engage in these communities without going out into the world and facing a lot of discrimination that others face. Allyship was always something that was a little bit scary to me, because I was worried that I would do something wrong. But at Stanford our community is small enough -- and you have enough touchpoints with everyone -- that there isn't that sense of: you send out an email that says something insensitive and you get flamed by 500 people on Twitter or something. I could learn and be corrected and approach this with humility, but also feel like I was being cared for at the same time.

What is something you're proud of from your time as a SUMMA leader?

I am so excited about the incoming medical student class. It is the most diverse incoming class in Stanford Medicine history, and so many of them expressed interest in social determinants of health and social justice in general.

I've been involved in the admissions process and in recruitment since my first year of medical school, and it has been one of our priorities at SUMMA to make our already small class sizes as diverse as possible. This year's success was a cumulative effort by the student leaders who planned interview days and revisit weekend, by the office of admissions and the financial aid office who worked with the students to make it possible for them to come here, and by our SUMMA organizations, who show these students the strength of our communities.

Why is it important to increase diversity and inclusion in the health professions?

There's a ton of data that shows that patients feel a lot more comfortable if they're treated by a doctor who they think understands their experience. And sometimes that boils down to identity.

I know that I have patients -- I have family members -- who will only see doctors who speak their language, which I completely understand. Or who will, if they have the freedom of choice, only see doctors who are of the same ethnicity as them. I think that's within the patient's right to decide, to an extent. I think it offers a better space for providing culturally humble care. And when we start having more providers that look like our patient demographic, then we will likely see better health care outcomes in the health care system.

Sometimes doctors or students are sort of told to "stay in our lanes." In other words, not to speak out on social issues. Why is it important that we speak out?

Because none of us operates in a vacuum.

The reason I came into medicine was because of the human side of things. That's what makes it interesting. What makes it complicated. And what gives value to this profession. I think to ignore the fact that we all live in a society that affects our health is misguided.

What advice do you have for people who want to be allies, but don't know how?

It's not going to be easy. A lot of us have really deeply embedded societal norms and different levels of self-awareness of those norms. But everyone in the SUMMA community is aware that people come here with the intention to learn.

We all have the capacity to learn. The hard thing is when that cognitive part comes at odds with the emotional part of being told you did something wrong at some point. I think, as high achievers, that's especially difficult to reckon with. But if you come at it from a place of humility -- and understand that the pain that some of these communities face day-to day is so much larger than you being told you're wrong -- it helps. It at least helps put me in the right headspace, which means putting my ego on the back burner.

Photo courtesy of Claire Rhee

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Arcturus Therapeutics & Duke-NUS Received Approval to Proceed with Phase 1/2 Clinical Trial for COVID-19 Vaccine Candidate, LUNAR-COV19 – BioSpace

Human dosing of LUNAR-COV19 expected soon

Differentiated STARR mRNA vaccine expected to produce humoral and cellular immunity at very low doses

New preclinical data demonstrates neutralizing antibody titers continue to increase for 50 days after a single administration

SAN DIEGO and SINGAPORE, July 21, 2020 (GLOBE NEWSWIRE) -- Arcturus Therapeutics, Inc. Holdings Inc.(the Company, Arcturus, Nasdaq: ARCT), a leading clinical-stage messenger RNA medicines company focused on the discovery, development and commercialization of therapeutics for rare diseases and vaccines, and Duke-NUS Medical School, Singapores flagship research-intensive graduate entry medical school, today announced that the Clinical Trial Application (CTA) for COVID-19 vaccine candidate LUNAR-COV19 has been approved to proceed by the Singapore Health Sciences Authority (HSA). Arcturus and Duke-NUS partnered to develop a coronavirus vaccine using Arcturus STARR technology and a unique platform developed at Duke-NUS allowing rapid screening of vaccines for potential effectiveness and safety.

Arcturus & Duke-NUS will initiate human dosing of LUNAR-COV19 as soon as possible. The healthy volunteer study will evaluate several dose levels of LUNAR-COV19 in up to 108 adults, including older adults. Follow-up will be conducted to evaluate safety, tolerability and the extent and duration of the humoral and cellular immune response.

The approval of the Clinical Trial Application for LUNAR-COV19 is a critical milestone for Arcturus. We are excited to advance this promising vaccine candidate into clinical trials. Based on our preclinical data, we believe that our self-replicating mRNA-based approach may produce high rates of seroconversion and robust T-cell induction with a potential single administration, at very low doses. The LUNAR-COV19 profile is meaningfully differentiated and may facilitate the mass vaccine campaigns necessary to target hundreds of millions of individuals globally, said Joseph Payne, President & CEO of Arcturus.

Professor Ooi Eng Eong, Deputy Director of the Emerging Infectious Diseases Program at Duke-NUS, said, Preclinical studies on LUNAR-COV19 have shown very promising findings, including the possibility that a single dose of this vaccine may be sufficient to trigger robust and durable immune responses against SARS-CoV-2. We are very eager to start the first-in-human clinical trial here in Singapore and advance LUNAR-COV19 on its journey to becoming a potential commercial vaccine.

There is a tremendous global imperative to develop effective preventive measures for COVID-19 infections. We are heartened by the rapid and promising progress in our vaccine collaboration with Arcturus as we move forward into clinical trials, said Professor Thomas M. Coffman, Dean of Duke-NUS Medical School.

The STARR Technology platform employed in LUNAR-COV19 combines self-replicating mRNA with LUNAR, a proprietary nanoparticle delivery system optimized for mRNA molecules. The efficiency and self-replicating nature of the approach were designed to enable very low doses, and a potential single vaccine administration. Prior animal data has demonstrated robust humoral and cellular immunity elicited at doses as low as 0.2 g of LUNAR-COV19. Additionally, Arcturus demonstrated 100% seroconversion for anti-SARS-CoV-2 neutralizing antibodies with a very low single dose (2.0 g).

New preclinical data demonstrate that neutralizing antibody levels in response to a single administration of LUNAR-COV19 (0.2, 2.0, 10.0 g) continue to increase over 50 days. The increasing antibody levels are attributed to the self-replicating mRNA of LUNAR-COV19. These results were obtained using a Luminex bead assay. A 1/2000 serum dilution was assayed for neutralizing IgG antibodies in the mouse serum every 10 days for 60 days post vaccination.

AboutArcturus TherapeuticsFounded in 2013 and based in San Diego, California, Arcturus Therapeutics Holdings Inc. (Nasdaq: ARCT) is a clinical-stage mRNA medicines and vaccines company with enabling technologies: (i) LUNAR lipid-mediated delivery, (ii) STARR mRNA Technology and (iii) mRNA drug substance along with drug product manufacturing expertise. Arcturus diverse pipeline of RNA therapeutic candidates includes programs to potentially treat Ornithine Transcarbamylase (OTC) Deficiency, Cystic Fibrosis, Glycogen Storage Disease Type 3, Hepatitis B, non-alcoholic steatohepatitis (NASH) and a self-replicating mRNA vaccine for SARS-CoV-2. Arcturus versatile RNA therapeutics platforms can be applied toward multiple types of nucleic acid medicines including messenger RNA, small interfering RNA, replicon RNA, antisense RNA, microRNA, DNA, and gene editing therapeutics. Arcturus technologies are covered by its extensive patent portfolio (192 patents and patent applications, issued in the U.S., Europe, Japan, China and other countries). Arcturus commitment to the development of novel RNA therapeutics has led to collaborations with Janssen Pharmaceuticals, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, Ultragenyx Pharmaceutical, Inc., Takeda Pharmaceutical Company Limited, CureVac AG, Synthetic Genomics Inc., Duke-NUS, Catalent Inc., and the Cystic Fibrosis Foundation. For more information visit http://www.ArcturusRx.com

AboutDuke-NUS Medical SchoolDuke-NUS is Singapores flagship graduate entry medical school, established in 2005 with a strategic, government-led partnership between two world-class institutions:Duke University School of Medicineand theNational University of Singapore(NUS). Through an innovative curriculum, students at Duke-NUS are nurtured to become multi-faceted Clinicians Plus poised to steer the healthcare and biomedical ecosystem inSingaporeand beyond. A leader in ground-breaking research and translational innovation, Duke-NUS has gained international renown through its five signature research programmes and eight centres. The enduring impact of its discoveries is amplified by its successful Academic Medicine partnership withSingapore Health Services(SingHealth), Singapores largest healthcare group. This strategic alliance has spawned 15 Academic Clinical Programmes, which harness multi-disciplinary research and education to transform medicine and improve lives. For more information, please visitwww.duke-nus.edu.sg

Forward Looking StatementsThis press release contains forward-looking statements that involve substantial risks and uncertainties for purposes of the safe harbor provided by the Private Securities Litigation Reform Act of 1995. Any statements, other than statements of historical fact included in this press release, including those regarding the Companys expected performance, the Companys development of any specific novel mRNA therapeutics, the Companys efforts to develop a vaccine against COVID-19, and therapeutic potential thereof, based on the Companys mRNA therapeutics, the forecasted safety, efficacy, characteristics or reliability of a vaccine against COVID-19, were one to be successfully developed based on the Companys mRNA therapeutics, the dosing level and frequency of a vaccine against COVID-19 were one to be successfully developed based on the Companys mRNA therapeutics and the impact of general business and economic conditions are forward-looking statements. Arcturus may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in any forward-looking statements such as the foregoing and you should not place undue reliance on such forward-looking statements. Such statements are based on managements current expectations and involve risks and uncertainties, including those discussed under the heading "Risk Factors" in Arcturus Annual Report on Form 10-K for the fiscal year ended December 31, 2019, filed with the SEC on March 16, 2020 and in subsequent filings with, or submissions to, the SEC. No assurances can be given that any results reported in pre-clinical studies can be replicated in further studies or in human beings, or that a vaccine can or will ever be developed or approved using the Companys technology. Except as otherwise required by law, Arcturus disclaims any intention or obligation to update or revise any forward-looking statements, which speak only as of the date they were made, whether as a result of new information, future events or circumstances or otherwise.

ContactArcturus TherapeuticsNeda Safarzadeh(858) 900-2682IR@ArcturusRx.com

Kendall Investor RelationsCarlo Tanzi, Ph.D.(617) 914-0008ctanzi@kendallir.com

Duke-NUS Medical SchoolLekshmy Sreekumar, Ph.D.(+65) 6516-1138lekshmy_sreekumar@duke-nus.edu.sg

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/fb3fb0a3-1978-4788-8811-57c446b49588

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Arcturus Therapeutics & Duke-NUS Received Approval to Proceed with Phase 1/2 Clinical Trial for COVID-19 Vaccine Candidate, LUNAR-COV19 - BioSpace

Upending the Dogma – Harvard Medical School

In a new study of human ear tissues, hearing scientists at Harvard Medical School and Massachusetts Eye and Ear have demonstrated that age-related hearing loss, also called presbycusis, is mainly caused by damage to hair cells, the sensory cells in the inner ear that transform sound-induced vibrations into electrical signals that are relayed to the brain by the auditory nerve. Their research challenges the prevailing view of the last 60 years that age-related hearing loss is mainly driven by damage to the stria vascularis, the cellular battery that powers hair cells mechanical-to-electrical signal conversion.

The inner ear, where most types of hearing impairment originate, cannot be biopsied, and its delicate structures can be resolved only in specimens removed at autopsy. Understanding the true cellular causes of age-related hearing loss impacts how future treatments are developed and how appropriate candidates will be identified and can also suggest how to prevent or minimize this most common type of hearing damage, according to the study authors. Pei-zhe Wu, HMS research fellow in otolaryngology head and neck surgery in the Eaton-Peabody Laboratories at Mass. Eye and Ear, led the study.

Our study upends the dogma about the major cause of age-related hearing loss, said Wu. Documenting the dominant role of progressive hair cell loss in the hearing impairment of normal aging means that the millions who suffer with this condition could benefit from the hair cell regenerative therapies that are the focus of ongoing research across the world. No one is focusing on approaches to regenerate the stria.

The new study was published online in theJournal of Neuroscience on July 20.

New techniques to uncover the true cause

Researchers examined 120 inner ears collected at autopsy. They used multivariable statistical regression to compare data on the survival of hair cells, nerve fibers and the stria vascularis with the patients audiograms to uncover the main predictor of the hearing loss in this aging population. They found that the degree and location of hair cell death predicted the severity and pattern of hearing loss, while stria vascularis damage did not.

Previous studies examined fewer ears, rarely attempted to combine data across cases and typically applied less quantitative approaches. Most important, prior studies greatly underestimated the loss of hair cells, because they didnt use the state-of-the art microscopy techniques that allowed Wu and colleagues to see the tiny bundles of sensory hairs that helped them identify and count the small number of surviving hair cells. These bundles were more than 200 times thinner than a typical human hair. Prior studies scored hair cells as present even if only one or two remained.

Cellular cause questioned

Age-related hearing loss is one of the most common conditions affecting older adults; about one in three people in the United States between the ages of 65 and 74 has hearing loss, and nearly half of those are 75 and older. The condition cannot be reversed and often requires hearing aids or other sound amplification devices.

Previous animal studies suggested that presbycusis is caused by atrophy of the stria vascularis, a highly vascularized cluster of ion-pumping cells located in the inner ear adjacent to the hair cells. The stria serves as a battery that powers the hair cells as they transform sound-evoked mechanical motions into electrical signals. In aging laboratory animals, such as gerbils, there is very little loss of hair cells, compared to that in humans, even at the end of life. However, there is prominent damage to the stria vascularis, and damage to the stria will, indeed, cause hearing loss. Prior to this new study, most scientists had assumed that the gerbil data also applied to human presbycusis.

The researchers say the new findings are good news given recent progress in the development of therapies to regenerate missing hair cells. If presbycusis were due primarily to strial damage, hair cell regeneration therapy would not be effective. This new study turns the tables and suggests that vast numbers of hearing-impaired elderly patients could likely benefit from these new therapies as they come to the clinics, hopefully within the next decade.

Importance of protecting ears from sound damage

Thedata also showed that hair cell degeneration in aging humans is dramatically worse than in animal models of presbycusis. Laboratory animals are aged in sound-controlled enclosures, where they are not exposed to the constant barrage of moderate and high-intensity noises that surround people.

The greater hair cell death in human ears suggests that the high-frequency hearing losses that define presbycusis may be avoidable, reflecting mainly accumulated damage from environmental noise exposures, saidM. Charles Liberman, the Harold F. Schuknecht Professor of Otology and Laryngology at Mass. Eye and Ear.

Its likely that if we were more careful about protecting our ears during prolonged noisy activities, or completely avoiding them, we could all hear better into old age said Liberman, who is also director of the Eaton-Peabody Laboratories at Mass. Eye and Ear and a co-author of the study.

Adapted from a Mass. Eye and Ear release.

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Upending the Dogma - Harvard Medical School

School of Medicine makes MCAT optional amid COVID-19 testing disruptions – The Stanford Daily

The School of Medicine announced in June that applicants would no longer be required to submit a Medical College Admissions Test (MCAT) score during the 2020-21 admissions cycle.

While submitted scores will not be used during the screening and initial review process for interview decisions, the submitted scores will be a part of the applicants file, according to Associate Dean of M.D. Admission Iris Gibbs.

As of July 8, all other application requirements remain the same for the School of Medicine. In future admissions cycles, Gibbs wrote in a statement to The Daily that the School of Medicine does not expect to abandon the exam requirement.

While there are concerns about the MCAT, a great deal of thought was put into formulating the new exam introduced in 2015, Gibbs wrote. Stanford Medicine values the MCAT as a useful tool.

Stanford joins UCSF in making MCAT scores optional during the screening and interview process, although several other peer medical schools have opted to wait for MCAT scores to come in, as opposed to making them optional. Harvard Medical School announced that it will accept MCAT scores at a later time, and UCLA will wait for a score before reviewing an applicants file, though its Vice Dean had signed a joint statement with Stanford in April reassuring that applications could be submitted by the October 15 deadline without an MCAT score.

The decision has drawn applause from some members of the medical community, with concerns over health and safety during in-person examinations no longer a worry. The lack of a standardized testing metric also relieves concerns over structural inequities, wrote Abdi Abdullahi, a third-year medical student at UCSF, in a statement to The Daily.

Historically, URM [underrepresented minority in reference] students have performed worse on the MCAT (largely influenced by SES [socioeconomic status] and structural racism), Abdullahi wrote. In this midst of a pandemic, with families strained economically, these inequities would be further enhanced.

Equitable access would not likely be possible

Gibbs wrote that the decision to waive the MCAT requirement was prompted by the cancellation of MCAT examinations through the end of May.

In late May, as the Association of American Medical Colleges (AAMC) resumed its examinations, the School of Medicine received concerns from applicants that the exam was difficult to schedule, unexpectedly canceled or unsafe to take.

To us it became clear that equitable access to the examination would not likely be possible despite AAMCs valiant attempt to do so, Gibbs wrote, AAMC acknowledged that there were errors in meeting social distancing guidelines in some testing centers in states experiencing recent COVID-19 surges, further validating our concerns for test takers.

An AAMC spokesperson wrote in a statement to The Daily that the AAMC requires social distancing at every MCAT exam.

Every exam that has been held has followed the AAMCs social distancing requirements, the spokesperson wrote.

But while the decision to waive or delay the MCAT requirement is recent, many students have been preparing for the exam for a long time.

Incoming Stanford Black Pre-Medical Organization co-president Ronald Clinton 21 wrote in a statement to The Daily that pre-med students are recommended to spend up to 350 hours studying for the exam.

So many students have already prepared or are currently preparing to take the exam and will only see it as a way to improve their application, Clinton said. I doubt that many students will op-out [sic] of taking the exam. The MCAT is just one more way of differentiating your profile from other applicants.

Gibbs wrote the MCAT score is only a small part of the application, a process that includes multiple letters of recommendation, personal statements and more.

So much more goes into the selection process other than metrics, Gibbs said. Our internal analysis reassures us that other factors in combination can be effectively used in the holistic review process even in the absence of the MCAT.

Equity concerns also led to Stanfords waiving of the MCAT, Gibbs wrote: COVID-19 contributed to existing inequities. We did not wish for applicants to place themselves and [their] families in more harm.

While Abdullahi wrote he thought all medical schools should waive the MCAT requirement during the pandemic, he wrote that the question of whether schools continue the use of the MCAT in post-pandemic admissions is an interesting one.

I believe schools should instead focus on an applicants experiences and motivations for pursuing medicine instead of a three digit numerical score, he wrote. Rankings like US News encourage medical schools to accept students with the highest exam averages, when that doesnt necessarily correlate to which applicants will make the best doctors.

Abdullahi wrote that other parts of the application process are inequitable, pointing to MCAT prep courses and admissions advising services with costs running into the thousands.

These services essentially gift wrap applications for students, making the process much easier to navigate for students who are wealthy, Abdullahi wrote.

On the other hand, Clinton wrote he thought schools could reform their evaluation criteria, as opposed to waiving the MCAT. He said that the MCAT can be improved to better reflect students abilities.

Being a doctor involves strong interpersonal communication skills, empathy, and being adaptable, Clinton wrote. It would be difficult to test these skills in a standardized test like the MCAT, but I believe some of these skills can be addressed more thoroughly in the exam.

This article has been corrected to reflect that UCSF has made MCAT scores optional during only the screening and interview process. A previous version of the article incorrectly stated that UCSF had made MCAT scores optional throughout the whole application process. The Daily regrets this error.

This article has been updated to include a statement from an AAMC spokesperson on the social distancing at MCAT exams.

Contact Anthony Wong at anthonytjwong at gmail.com

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School of Medicine makes MCAT optional amid COVID-19 testing disruptions - The Stanford Daily

Dimensions of time: Starting medical school in the COVID-19 era – Baylor College of Medicine News

I didnt learn how to tell time until age nine. I had somehow missed the important lesson on how to read the hands on a clock in preschool, and my fourth-grade teacher eventually noticed this gap in my knowledge.

Amidst the COVID-19 pandemic, time has felt like a daunting, perplexing concept. The pandemic has turned life as we know it on its head, and left me wondering how to appreciate the present, amid an uncertain world facing unparalleled challenges and the unknowns of my career path.

I have spent the last three months with my parents, younger sister, and two goofy Australian shepherds, the longest consecutive amount of time with them since I was 13 years old. I have grown much more adept at remote work, juggling Zoom calls and email updates with Box uploads and a more relaxed professional wardrobe (read: athletic shorts).

I listen to lots of podcasts on my neighborhood walks. I FaceTime with friends more regularly than ever. My sister and I hone our crossword-solving skills daily. Against the backdrop of these activities in our new normal, the days run into one another as we stay home.

Yet, I keep watching the time. I check my countys COVID-19 case count every night. I keep track of the number of weeks of social distancing in my city. In my daily news consumption, I also watch the time. I learn the time since China identified its first cases of COVID-19. I realize how long it has been since New York Gov. Andrew Cuomo gave his first COVID-19 briefing to a virtual audience seeking leadership and integrity during a crisis. I count the days that turn into weeks since the Black Lives Matter movement became a national outcry for reform with the death of George Floyd.

I also know that I have one month until medical school.

My one-month countdown to the first day of medical school feels impossibly surreal. There seemed to be an endless amount of time before this moment of beginning my medical education. There were inordinate hours spent studying for the MCAT, innumerable drafts of my personal statement, and countless worries about where I would end up and if this long-time dream would become a reality. Now, it is real, and it is happening. I am starting medical school.

I am excited. I am nervous. I am open-minded. I hope to care for my patients, my colleagues, and my work with empathy, diligence, and compassion. As COVID-19 has wreaked havoc on our world, I am grateful and inspired by the admirable efforts of essential workers across all sectors to keep the world running. I welcome the chance to enter a profession that allows me to show up and serve.

Life is still moving along, and it feels as if the hands on the clock move faster than ever. I often find it tempting to live in the world of what happens next. It is a way of exercising control, of holding on tight to something as the right now seems to slip away. When school starts, I want to learn from and grow alongside my classmates. I want to delve into the academic material, memorizing obscure bones I did not even know existed or learning how a certain drug works.

I want to find mentors and role models in class and clinical settings who teach me what type of physician I hope to be and what I need to know to get there. I know that these experiences may look different due to our unique circumstances.

In medicine, time matters. Physicians ask about time to understand the gravity of the situation, inquiring about the length of time someone has been without oxygen or the length of time for which someone at the scene did chest compressions. The medical records track time, graphing BMI and height over the time between visits or noting the times of admission and discharge.

During the pandemic, the world has glimpsed the sheer power of time in medicine. We have all heard of COVID-19 patients facing a disease course stretching on for weeks and physicians raising alarms about their hospitals dwindling supply of masks as COVID-19 cases surge.

As a country, we have questioned the time with which we acted in response to the virus and wondered, through graphs, articles, conversations, tweets, and everything in between, how this all could have been different if we could turn back the clock.

Time also matters in our medical training. Stepwise learning in pursuit of becoming excellent physicians does not stop for a pandemic. Instead, it just might look different as fourth-year medical students start residency earlier or have a virtual graduation.

We are all moving forward amidst a pandemic, a racial reckoning, and a searing exposure of societal inequities and disparities. The world is changing, and I am becoming a doctor. I am realizing that there is time for both.

-By Hannah Todd, incoming first-year medical student at Baylor College of Medicine

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Dimensions of time: Starting medical school in the COVID-19 era - Baylor College of Medicine News

Varun Saraswathula | Doctors are facing a silent mental health crisis and they need help – The Daily Pennsylvanian

In April 2020, New York City resembled a ghost town with empty streets and shuttered businesses. In the days following Governor Andrew Cuomos stay-at-home order, the most populous city in the United States fell silent, except for the eerie echoes of loudspeakers urging individuals to maintain physical distance. Inside the citys emergency rooms and hospitals, however, healthcare workers were facing the worst experience of their careers. Forced to work with insufficient equipment, personnel, and space, New York Citys physicians were at the mercy of an illness they barely understood.

One of those physicians was Dr. Lorna Breen, an emergency medicine doctor at New York-Presbyterian Allen Hospital. Dr. Breen was a well-loved and respected clinician, but unable to cope with the incomprehensible agony of the pandemic at its height. She died by suicide in late April.

Stories like Dr. Breens are distressingly common even prior to the COVID-19 pandemic. A 2019 study asserts that the suicide rate is higher among doctors than in the general public, as are instances of depression. In the first year of postgraduate medical training, depressive symptoms increase 15.8% across resident physicians, and during residency training, anywhere between 20-45% of residents report symptoms of depression. Later on, depression and suicide remain as huge issues for physicians outside of their training.

Why? Obviously, physicians see and deal with a lot of trauma in their careers, so its not surprising that emotional discomfort is prevalent. Having to deal with death on a regular basis and having such an outward facing job leads to compassion fatigue, often leading to burnout and mental illness. At the same time, mental illness is a debilitating source of humiliation in medicine, often being perceived as a sign of weakness and an inability to handle the rigors of the profession.

Dr. Breens passing reignited a conversation surrounding well-being among physicians, but struggles with mental health often begin more than a decade before medical practice itself. Premedical students represent a sizable portion of the undergraduate population, and very early on in their careers, are accustomed to a cut-throat environment. [Mental health] is not viewed as a priority, says Heta Patel, a rising College senior studying Health and Societies, and a premedical student herself. Getting into a good medical school, doing well... those sorts of things are put first.

Its true. A 2010 study found that premeds, especially those who are female or Hispanic, exhibit signs of severe depression more frequently than non-premeds. Despite this prevalence, premeds are often reluctant to admit to these struggles, especially on their applications, out of fear of jeopardizing their chances of being accepted into a program. Its an open secret that programs are biased against applicants with a prior history of mental illness, and even though an applicant might see their illness as an experience crucial to their desire to serve others in a clinical context, many claim that its a surefire way to torpedo an application.

This attitude is prevalent throughout undergraduate medical education, which is often analogized to drinking from a firehose. The first two years of medical school are the preclinical years, where students take coursework in the basic science of medicine, but the rigor can be unlike anything experienced in college. For the most part, the preclinical medical school experience depends on where one trains. Ive had friends who were premed with me, went to different schools, and were really just working to the bone the first two years, says Matt Kubicki, a fourth-year medical student at the Perelman School of Medicine. Its mostly just a preclinical [curriculum]: study, take tests, do anatomy lab, that sort of thing.

Kubicki describes Penn as being more relaxed, even going as far as saying that his preclinical years were less stressful than his time as an undergraduate trying to get into medical school. He attributes this to the pass/fail grading system Penn utilizes when evaluating students in their preclinical years. At Penn our first semester is pass/fail, and even after that theres honors, but it doesnt really matter as much as the grades that we get during our clinical year, he says.

The third year of medical school is the clinical year, where students are able to escape the classroom and rotate in different clinical settings, gaining an understanding of how to practice medicine. While its undoubtedly exciting for many students to get their hands dirty, starting clinical year can be an adjustment that comes with its own set of mental health challenges.

The clinical year is universally hated among most med students, admits Kubicki. I mean it is exciting, youre finally getting to be in clinics, but unfortunately I think it needs to be overhauled a lot more. He describes the clinical year as when medical students are thrown into many different work settings with minimal guidance and constant evaluation. But the worst part? The isolation. When clinic time came, I just wasnt seeing anyone except my roommates, says Kubicki.

Ultimately, medical students work through those clinical rotations to become accepted into a residency program, a graduate medical education program where physicians train in their chosen subspecialty for an additional number of years after graduating medical school. Residents are likely to experience or have exacerbated difficulties in mental health. They face tremendous stress in their careers: substantial workloads, deprived sleep, and work-related compassion fatigue are common and expected. A 2018 study surveyed 18% of the resident physicians at an academic medical center in Chicago, IL, and 61% admitted that they could have benefited from psychiatric services, yet only 24% of those individuals actually solicited treatment. Major concerns for seeking care for mental health include a lack of time, fear of judgement from others, and fear of being unable to obtain licensure.

One of the biggest barriers to seeking mental health treatment among physicians is the fact that state medical licensure boards can ask invasive questions about psychiatric history, which the Department of Justice and numerous court decisions found violate the Americans with Disabilities Act. While the intrusiveness of some questioning has become muted due to legal recourse, some argue that they are still disconcertingly personal. Regardless, it dissuades many physicians from seeking treatment for fear of having such information become available. Notably, however, the mental health condition that receives the greatest scrutiny among physicians is substance abuse.

A 2009 study suggests that between 10-12% of physicians develop a substance abuse disorder during their careers, and the perceived social status of physicians often precludes them from getting help. Kubicki, who is interested in addiction medicine, submits that many of the traits that allow physicians to succeed actually put them at greater risk for developing drug or alcohol problems. A lot of medical students are used to being the know-it-alls who are high achievers... but where that can go wrong is if we suddenly start struggling, we are much less likely to ask for help, he says.

The doctors that ultimately do ask for help are placed into intense investigation. Special rehabilitation programs exist for physicians aiming to achieve sobriety, and relicensure always depends on the successful completion of these programs. It is, in a way, voluntary, but its not, says Penn Department of Psychiatry's Dr. Claudia Baldassano. Dr. Baldassano referred a patient of hers with an alcohol problem (who was a medical student at the time) to one such program. Penn Medicine would not allow this student to remain a student unless [they] enrolled voluntarily in this program. Dr. Baldassano noted that the patient was able to become sober, graduate, and begin residency, ultimately overcoming their problem and becoming a clinician.

The COVID-19 pandemic especially increases workload and stress for many physicians, and their mental health is at greater risk now than ever. Increased sanitation and distancing measures in hospitals make it difficult for doctors to spend time with one another like they once did. One of the best things about residency is the colleagues that you work with and the social connections that you get to build both inside and outside of the hospital, says Dr. Benjamin Lerman, a Pediatrics Resident at the Childrens Hospital of Philadelphia. At the height of the pandemic when we didnt know what the transmissibility of COVID was, we werent even allowed to be in the same room as each other, which was really socially isolating... that takes a mental toll when youre on call in the hospital for 28 hours.

Dr. Baldassano, who is also the Director of Penns Bipolar Outpatient Clinic, notes that she already received two new patient referralsboth of whom are physiciansas a direct result of the pandemic. One became manic in the setting of COVID-19 and increased work hours which led to disruption in sleep, she says. It... fomented what was probably an underlying bipolar disorder that... presented itself to the point where the person became so grandiose they thought they were going to be the one to solve the whole COVID problem.

Historically, medicine rarely discusses mental health within the ranks, but the overwhelming stress of the pandemic hasout of necessitymade administrators prioritize mental health at many levels of the healthcare world. Kubicki notes that in his opinion, Penn Medicine did a better job of addressing mental health concerns during the pandemic than they typically had before. It was kind of like because this was such a big shock to everyones systems, they just flat out from the beginning were like, Hey, if you need to talk about how the pandemic is affecting you, we got these resources all for you, he says. Penn Medicine recently introduced COBALT, a new mental health platform for physicians to receive confidential peer counseling and assistance coping with the trauma of the pandemic.

Even in the allied health professions, COVID-19 introduced broad discussions surrounding mental health where they did not exist before. The first time that ever happened was during coronavirus, says Jennifer Ben Nathan, an Emergency Medical Technician, referring to a supervisor offering to speak to EMTs stressed out from taking calls during the pandemic. Ben Nathan is a rising College sophomore and is working in Emergency Medical Services for 3.5 years now. She describes the culture in EMS as one that rarely discusses mental health, and that those conversations only arise in events of excessive trauma. They only kind of come up if something disturbing happens and we have to deal with it, but otherwise everyone kind of keeps quiet about it and you just kind of carry on, she says. How else are you going to do your job?

Physicians and administrators need to understand that being open, vulnerable, and fallible actually help doctors do their job. This shame associated with mental illness is simply incommensurate with the emotional toll that medicine inevitably takes on practitioners, but its ingrained into every aspect of medical training. If we want more people to enter medicine and operate to the best of their abilities, we have to acknowledge and honor the unimaginable sacrifices they make, and allow them to process trauma in a productive and healthy way.

The silver lining of the COVID-19 pandemic is that it forces a reckoning in medicine. It creates an environment so traumatic for many physicians, that for the first time, people in the field are willing to speak up and set aside stigmas for the sake of practitioners. The worst thing that can happen, however, is if we allow these discussions to regress post-pandemic, and return to a state where physicians once again fear admitting weakness and keep indulging in the tough culture medicine embodied. Changing that culture will require sustained involvement from administrators at every level of medicine, but especially in undergraduate medical education, where members of the next generation of physicians are being molded by one another.

The issue is that sustained involvement comes at a price. It costs money and it requires a structural investment, says Dr. Lerman. But, I think were moving in that direction, it just takes time.

VARUN SARASWATHULA is a rising College junior from Herndon, V.A. studying the Biological Basis of Behavior and Healthcare Management. His email is vsaras@sas.upenn.edu.

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Varun Saraswathula | Doctors are facing a silent mental health crisis and they need help - The Daily Pennsylvanian