Ukraine says ‘moving forward’ along parts of Bakhmut front – Macau Business

A senior Ukrainian military commander said Saturday that Kyivs forces were advancing along parts of the front line against Russian forces near the eastern town of Bakhmut.

Our soldiers are moving forward in some areas of the front, and the enemy is losing equipment and manpower, Commander of Ukrainian ground forces Oleksandr Syrskyi said on social media.

The defensive operation in the Bakhmut direction continues.

Earlier Saturday the Germany defence ministry said the country was preparing a new weapons package for Ukraine worth 2.7 billion euros, reportedly Berlins largest since Russia invaded last year.

Kyiv said that the massive new weapons package from Germany was another sign that Russia would lose in its war against Ukraine.

States declare large defence aid packages for Ukraine, said Mykhailo Podolyak, an adviser to Ukrainian President Volodymyr Zelensky.

He said that the aid indicated that Russia was bound to lose and sit on the bench of historical shame.

Ukraines Foreign Minister Dmytro Kuleba said that he discussed next weapons supplies with US Secretary of State Antony Blinken.

I paid close attention to the importance of providing Ukraine with F-16s and steps necessary to begin training of Ukrainian pilots, he added.

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Ukraine says 'moving forward' along parts of Bakhmut front - Macau Business

‘Nothing left’ as looting guts Sudan’s already crippled economy – Macau Business

A month ago, Mohsen Abdelrahman owned a small but profitable jewellery store in Khartoum. Now, he has nothing to his name but a broken lock and a hollowed-out shopfront.

Ten days after battles broke out between two rival Sudanese generals, he received a call from the shopkeeper next door to his business saying it had been looted.

Despite the danger, Abdelrahman braved the relentless gunfire and air strikes ravaging the capital to get to his store on the other side of town, only to have his worst fears confirmed.

Everything I owned was gone, he told AFP, adding that now he just wants this war to end, so I can start over.

There is no end in sight to the conflict pitting the forces of army chief Abdel Fattah al-Burhan against those of his deputy-turned-foe Mohamed Hamdan Daglo, who commands the paramilitary Rapid Support Forces.

But even before the fighting broke out, Sudan was one of the worlds poorest countries, brought to its knees by decades of international sanctions under former dictator Omar al-Bashir, as well as rampant corruption and the 2011 independence of South Sudan which held almost all the countrys oil.

After a brief respite following Bashirs ouster, a 2021 coup led by Burhan and Daglo saw the international community cut $2 billion of annual aid to the country, slashing 40 percent of its budget.

The economy has been in free fall since, with the government never announcing a 2023 budget but instead boasting that dizzying inflation had recently fallen under 100 percent.

Prior to the ongoing conflict, Khartoum saw signs of economic renewal, with international restaurants and supermarkets stocked with organic food and American goods although much of it was smuggled through the Sahel.

But nowadays Khartoum, which is home to five million people, is a city whose shattered windows, gutted shopfronts, pockmarked cars and empty shelves bear witness to the rampant violence and looting.

Khartoum airport, now a shell of its former self, has been shut down since the fighting began on April 15.

Sudan once depended on vital trade coming through Port Sudan on the Red Sea, where now only planes and ships full of fleeing civilians take off, and crucial humanitarian aid trickles in.

Nothing has been spared from the looting, including hospitals, humanitarian organisations, and the abandoned houses of more than 500,000 people who fled the capital for neighbouring towns, or other countries.

Noureddine Adams mobile phone store was no exception. On the fifth day of the conflict, a lock was broken and his shop was ransacked.

They didnt leave anything, and now I have nothing left, he told AFP.

In addition to having lost their inventory, shop owners and traders like Adam are now saddled with debt, he said.

According to a customs official who spoke to AFP on condition of anonymity, the Soba container terminal south of Khartoum where imports are processed before coming into the capital and other areas has been stripped bare.

It was all products from abroad that had come in and were waiting to be processed, but their importers couldnt come and finish the paperwork because of the war, he said.

According to witnesses in Khartoum North, wheat silos at Sayga, Sudans largest producer of flour, have been emptied out a potential disaster for a country where the UN predicts 19 million people could be food insecure within six months.

Khartoum residents have tried to hold out hope, even while sheltering under air strikes and seeing their fleeing neighbours homes broken into and ransacked.

But Abdeldayem Omar knows his clothing store is gone for good.

On the third day of the war, a rocket fell on the market, he told AFP.

Some stalls burned to the ground, including mine. Others partially survived the flames, but whatever was left was looted.

The irony, according to him, is that the main police station in the district is headquartered inside the market itself.

But the police have completely disappeared, and theres no protection left.

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'Nothing left' as looting guts Sudan's already crippled economy - Macau Business

Sudanese fleeing war find their homes occupied by fighters – Macau Business

Like many Sudanese forced to flee their homes amid raging street battles, Mohamed said that when he finally returned to his flat, he found heavily armed paramilitaries had moved in.

After cautiously approaching his Khartoum apartment block, he discovered that the entire building had become like a military barracks filled with weapons and ammunition.

Almost a month of heavy fighting has turned Khartoum into a war zone, with the citys five million residents enduring artillery barrages, gunfights, air strikes and anti-aircraft fire.

Many have hunkered down at home amid power outages and a lack of clean water, food and medicines but many have also been forcefully evicted.

The northern suburb where Mohamed lived has become a major battleground in the war between army chief Abdel Fattah al-Burhan and Mohamed Hamdan Daglo, commander of the paramilitary Rapid Support Forces (RSF).

After Mohameds family had spent terrifying days at home, waking and sleeping to deafening explosions and gunfire outside, RSF fighters came to evict them.

They knocked on the door and asked us to leave, said the 54-year-old, who like others interviewed by AFP for this article asked not to be identified by his full name citing security fears.

Before leaving home, Mohameds family took what they could carry and locked their doors, he added.

When he returned days later to collect some belongings, Mohamed was interrogated by the RSF paramilitaries whom he had found sitting inside his apartment.

Witnesses in Khartoum say RSF fighters have often taken up positions in leafy residential streets, with soldiers hiding camouflaged trucks under trees.

Men in military fatigues patrol in pick-up trucks mounted with heavy machine guns.

Another man, Babiker, 44, said he fled his home in central Khartoum amid incessant gunfire, only to return two weeks later to find it occupied by the RSF.

I found more than 20 paramilitaries living there,he said, adding he was interrogated for half an hour before being allowed entry.

They were using all appliances and cooking in our kitchen, he said. All the bedrooms that we had locked before leaving were open.

Sudans bitter fighting has so far killed at least 750 people, wounded thousands and uprooted hundreds of thousands, with many refugees fleeing the country.

The UNs human rights commissioner, Volker Turk, said the RSF had allegedly taking possession of many buildings in Khartoum to use as operational bases, evicting residents and launching attacks from densely populated urban areas.

He also criticised Sudans military for launching attacks in densely occupied civilian areas, including air strikes that have killed residents.

The paramilitaries have also turned many hospitals and medical facilities into barracks a practice the UN World Health Organization has condemned as a gross violation.

Even diplomatic missions in Khartoum have not been spared.

On May 3, Saudi Arabia said an armed group had stormed its cultural office and damaged appliances, cameras, and seized some property.

The European Union said on April 17 that its ambassador was assaulted in his residence, labelling the attack a gross violation of the Vienna Convention.

Last Wednesday, the RSF took over my family house in Khartoum, where my cousins and I have our documents, valuables, and all our memories, one Sudanese woman wrote on Twitter.

Its confirmed by the only neighbour left in the neighbourhood that it is the RSF.RSF soldiers are going out of control, out of Hemetis control, she added, referring to General Daglos nickname.

Another citizen, Tahany, 33, escaped her home when fighting intensified in the area near Khartoums airport.

Having abandoned hopes for an end to the fighting, she decided to join the tens of thousands of Sudanese making the long, arduous trip to Egypt but she first needed to return home to get her travel documents.

Paramilitaries at checkpoints interrogated us as we were trying to return to our neighbourhood, and every time we told them we wanted to pick up some things from our home, she said.

Eventually, Tahany and her mother were allowed entry to the home, escorted by paramilitaries.

We found that all our home items had been used, from the kitchen to the beds, she said.They even mounted a weapon on the balcony on the second floor.

Terrified, Tahany and her mother frantically searched for their travel documents and rushed out.We are now on our way to Egypt, she said. We dont know what has become of our home.

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Sudanese fleeing war find their homes occupied by fighters - Macau Business

Erdogan leads prayers on eve of fight for political life – Macau Business

Turkish President Recep Tayyip Erdogan will lead Saturday prayers at Istanbuls iconic Hagia Sophia mosque, ahead of a battle for his political life against a powerful secular rival.

The 69-year-old will be emulating a ritual that Ottoman Sultans performed before they led their men off to war as he braces for Sundays parliamentary and presidential ballot.

Erdogan has never faced a more energised or united opposition than the one led by retired civil servant Kemal Kilicdaroglu and his disparate alliance of six parties.

The Turkish leader excelled at splitting his rivals and forging unlikely unions while winning one national election after another over 21 years.

But his Islamic-rooted party is reeling from anger over Turkeys economic meltdown and a crackdown on civil liberties during Erdogans second decade of rule.

The six opposition parties have put aside their political and cultural differences and joined forces for the lone task of pushing Erdogan out.

They are officially supported by Turkeys main pro-Kurdish party a group that accounts for at least 10 percent of the vote.

The math is not adding up in Erdogans favour and most polls show him trailing his secular rival by a few points.

Kilicdaroglu is now desperately trying to break the 50-percent threshold and avoid a May 28 runoff that could give Erdogan a chance to regroup and reframe the debate.

Are you ready to bring democracy to this country? To bring peace to this country? I promise, I am ready too, Kilicdaroglu told a rally in Ankara.

Erdogan was put in the uncomfortable position on Friday night television of being asked what he would do if he lost.

The veteran leader bristled and pledged to respect the vote.

This is a very silly question, he said.

We came to power in Turkey by democratic means, with the approval of our people. If our people were to change their mind, we would do what democracy requires.

His campaign path to re-election will take him to the scene Saturday of one of the more controversial decisions of his recent rule.

The Hagia Sophia was built as a Byzantine cathedral once the worlds largest before being converted into a mosque by the Ottomans.

It was converted into a museum when Mustafa Kemal Ataturk created a secular post-Ottoman Turkey in 1923.

Erdogans decision to convert it back into a mosquein 2020 solidified his hero status among his religious supporters and contributed to growing Western unease with his rule.

The entire West got mad but I did it, Erdogan told an Istanbul rally on Saturday.

Erdogan has played up religious themes and used culture wars to try and energise his conservative and nationalist base.

He brands the opposition as a pro-LGBT lobby that takes orders from outlawed Kurdish militants and is bankrolled by the West.

The strident message appears to be aimed at taking voters minds off Turkeys most dire economic crisis of his entire rule.

The official annual inflation rate touched 85 percent last year. Economists think the real figure could have been much higher and blame the crisis on Erdogans unconventional financial theories.

Kilicdaroglu pledges to do away with them immediately after taking office.

But the starkness of the choice confronting Turkeys 64 million voters is accompanied by soaring tensions and lingering fears over what Erdogan would do if he lost a narrow vote.

Kilicdaroglu wore a bulletproof vest to his two rallies on Friday after receiving what his party described as a credible threat on his life.

He gave an uncharacteristically short evening speech in Ankara that was originally played up by his campaign.

Kilicdaroglus running mate Ekrem Imamoglu a popular figure who beat Erdogans ally in controversial 2019 Istanbul mayoral polls was pelted by rocks days earlier while touring Turkeys conservative heartland.

Turkish officials launched a formal investigation and made some arrests.

But several senior officials in Erdogans ruling party accused the Istanbul mayor of provoking the incident.

The voting will include southeastern regions that lie in ruins in the wake of a February quake that claimed more than 50,000 lives.

The level of anger in these traditionally pro-Erdogan regions could also help swing Sundays outcome.

Were not happy to be voting in the middle of rubble, but we want the government to change, said Diber Simsek, a resident of the city of Antakya that sustained major damage in the disaster.

by Fulya OZERKAN with Burcin GERCEK in Ankara and Remi BANET in Antakya, Turkey

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Erdogan leads prayers on eve of fight for political life - Macau Business

Temperature in Singapore soars to 40-year high: officials – Macau Business

Singapore reported its highest temperature in 40 years on Saturday, officials said, as a blistering heatwave burns through large parts of South and Southeast Asia.

Saturdays temperature of 37 degrees Celsius was the highest this year, and matches the record for a daily peak recorded in April 1983, the National Environment Agency said on Facebook.

The current warm and dry conditions are expected to continue tomorrow, the agency said on Saturday.

Short-duration showers are expected next week which may help to moderate the warm temperatures, it added.

May is normally one of the warmest months of the year, according to the NEA.

Some schools in the city-state have relaxed rules on uniforms over the rising mercury in recent days, according to local broadcaster Channel News Asia.

Vietnam reported a record temperature of 44.1 degrees Celsius last week, with its state electricity company warning that the national power system would come under strain this summer due to anticipated heatwaves.

Scientists say global warming is exacerbating adverse weather, with a recent report from the UNs Intergovernmental Panel on Climate Change warning that every increment of global warming will intensify multiple and concurrent hazards.

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Temperature in Singapore soars to 40-year high: officials - Macau Business

China wants Macau to break its gambling addiction – The Economist

STAKES IN PUNTO BANCO, a popular version of the card game baccarat, have often risen to well over $100,000 in Macaus VIP suites. The high-rollers have usually come from the Chinese mainland. Even before flying into the gambling haven they would commonly agree to bet upwards of $1m during their stays. Those who have arrived short of cash because of the mainlands strict capital controls have easily found lenders of Macanese patacas.

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The flow of super-rich punters from the mainland has been enabled by junket agents and promoters. In 2019 SJM Holdings, which owns a huge French Renaissance-style casino in Macau, brought in almost all of its VIP customers through such middlemen. The share of non- VIP gambling in the city has been rising in recent years. But before the pandemic, VIPs still accounted for about a third of the territorys gross revenues from gaming.

Covid-19 has been a blow to the industry. So, too, have stepped-up efforts by Chinas government to curb the junket business. Betting is illegal on the mainland. In March China said assisting cross-border gambling was also against the law. On November 26th police in the coastal city of Wenzhou issued an arrest warrant for Alvin Chau, the head of SunCity, Macaus biggest junket firm. He was later seized in Macau. Officials there claimed this was unrelated to the mainlands warrant, but many in his business felt a deep chill.

The charges against Mr Chau hint at the scope of the junket industry in Macau. Wenzhous police say he had 12,000 agents serving 80,000 customers on the mainland. SunCity allegedly arranged underground banking services to help them evade capital controls. Junkets are legal in Macau. But the mainlands laws appear to have trumped local ones.

How will Macau survive? China wants to see it transformed from a city of vice into a regional entertainment centre and tech hub. This has proved difficult because most of its available land has been used to build casinos. Macaus government hopes a new development zone will help. It is on nearby Hengqin, an island three times Macaus size. It belongs to the mainland and has been leased in part to Macau. Hengqin will have theme parks, family attractions and a high-speed rail link with Chinas interior. The former Portuguese enclave will become even more like a mainland city.

This article appeared in the China section of the print edition under the headline "No dice for vice"

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China wants Macau to break its gambling addiction - The Economist

DJ loses more than RM400,000 in Macau scam – The Star Online

JOHOR BARU: A deejay at an entertainment centre here lost more than RM400,000 of her savings after falling for a Macau scam.

Johor police Commercial Crime chief Asst Comm Amran Md Jusin said the 45-year-old woman lodged a police report on Sunday (Dec 12).

She received a call on Dec 1 at around 1pm from a male caller who identified himself as an officer from Telekom Malaysia.

The caller told the victim that she had been 'blacklisted', claiming that she had many unpaid phone bills and he would call her again soon, he said in a statement Monday (Dec 13).

ACP Amran added that the victim then received another call from a mobile number, this time from a woman who identified herself as Inspector Ling from Kuantan police headquarters, claiming that she could help the victim by making a police report online.

He said the inspector then told the victim that after checking her name, it had been found that she was involved in illegal money laundering activities.

This 'inspector' then ordered the victim to make several monetary transactions into several bank accounts given for investigative purposes and the money would be returned to her once it was complete.

The victim followed the instructions and made 58 transactions to eight bank accounts between Dec 2 and 9, amounting to RM419,050, before realising she had been cheated after trying to call the 'inspector' several times and not getting an answer, he added.

ACP Imran said the case was being investigated under Section 420 of the Penal Code for cheating.

He reminded the public to always be vigilant especially when receiving calls from unknown callers claiming to be from enforcement agencies.

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DJ loses more than RM400,000 in Macau scam - The Star Online

Arbutus and Qilu Pharmaceutical Enter into an Exclusive Licensing Agreement and Strategic Partnership to Develop and Commercialize AB-729 in mainland…

Qilu Pharmaceutical, one of the leading pharmaceutical companies in China, becomes strategic partner to provide development, manufacturing and commercialization expertise for the mainland China, Hong Kong, Macau and Taiwan markets

Arbutus to receive $40 million in an upfront payment, up to $245 million in development and commercialization milestone payments, double-digit tiered royalties and a $15 million equity investment

WARMINSTER, Pa. and JINAN, China, Dec. 13, 2021 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (Nasdaq: ABUS), a clinical-stage biopharmaceutical company dedicated to developing a cure for people with chronic hepatitis B virus (HBV) infection, and Qilu Pharmaceutical, one of the leading pharmaceutical companies in China, today announced that the companies have entered into an exclusive licensing agreement and strategic partnership for the development and commercialization of AB-729 for the treatment or prevention of hepatitis B in mainland China, Hong Kong, Macau and Taiwan.

AB-729 is Arbutuss lead RNA interference (RNAi) therapeutic that is currently in multiple Phase 2aproof-of-concept clinical trials designed to evaluate it in combination with other approved or investigational agents.

William Collier, President and Chief Executive Officer of Arbutus Biopharma, commented, Qilu is an ideal partner for our AB-729 RNAi therapeutic given their extensive development, regulatory and commercialization capabilities in China. We are now positioned to bring AB-729 to the largest HBV patient population in need of a cure and to tap into one of the largest and most promising healthcare markets worldwide. We are committed to working with Qilu in this partnership which further validates the potential of AB-729 to address the unmet medical need in HBV.

Qilu Pharmaceutical Chief Executive Officer, Ms. Yan Li commented, The HBV patient population is significant in China. Based on clinical data achieved to-date, we believe in the potential of AB-729 to be a safe and effective treatment option in treating HBV. We look forward to collaborating with Arbutus to maximize the potential clinical value that AB-729 can bring to and benefit the millions of underserved HBV patients in China.

Under the terms of the agreement, Arbutus will receive a $40 million upfront payment and will be entitled to additional payments of up to $245 million upon reaching certain development, regulatory and sales milestones. The above amounts are net of withholding taxes. Qilu will be responsible for funding all development and commercialization activities for mainland China, Hong Kong, Macau and Taiwan. Arbutus is also entitled to receive double-digit tiered royalties up to the low twenties percent on annual net sales. In addition, Qilu will make a $15 million equity investment in Arbutus common shares at a price of $4.19 per share, a 15% premium of Arbutus previous 30-day average closing stock price calculated from December 10, 2021.

The common shares to be sold in the private placement have been offered only to certain institutional and/or accredited investors in reliance upon an exemption from the registration requirements of the Securities Act of 1933, as amended (the Securities Act). The common shares have not been registered under the Securities Act or any state or other securities laws and may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements of the Securities Act and applicable state securities laws. The Securities and Exchange Commission has not passed upon the merits of or given its approval to the common shares, the terms of the private placement or the accuracy or completeness of any private placement materials. The common shares sold in the private placement are subject to legal restrictions on transfer.

This press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification or otherwise under the securities laws of any such state or jurisdiction.

About AB-729

AB-729 is an RNA interference (RNAi) therapeutic specifically designed to reduce all HBV viral proteins and antigens, including hepatitis B surface antigen, which is thought to be a key prerequisite to enable reawakening of a patients immune system to respond to the virus. AB-729 targets hepatocytes using Arbutus novel covalently conjugated N-acetylgalactosamine (GalNAc) delivery technology that enables subcutaneous delivery. Clinical data generated thus far has shown single- and multi-doses of AB-729 to be generally safe and well-tolerated while providing meaningful reductions in hepatitis B surface antigen and hepatitis B DNA.

About HBV

Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). HBV can cause chronic infection which leads to a higher risk of death from cirrhosis and liver cancer. Chronic HBV infection represents a significant unmet medical need. The World Health Organization estimates that over 250 million people worldwide suffer from chronic HBV infection, while other estimates indicate that approximately 2 million people in the United States suffer from chronic HBV infection. Approximately 900,000 people die every year from complications related to chronic HBV infection despite the availability of effective vaccines and current treatment options.

About Arbutus

Arbutus Biopharma Corporation (Nasdaq: ABUS) is a clinical-stage biopharmaceutical company primarily focused on discovering, developing and commercializing a broad portfolio of assets with different modes of action to provide a cure for people with chronic hepatitis B virus (HBV) infection. The Company is advancing multiple product candidates with distinct mechanisms of action that suppress viral replication, reduce surface antigen and reawaken the immune system. Arbutus believes this three-prong approach is key to transforming the treatment and developing a potential cure for chronic HBV infection. Arbutus HBV product pipeline includes RNA interference (RNAi) therapeutics, oral capsid inhibitors, oral compounds that inhibit PD-L1 and oral HBV RNA destabilizers. In addition, Arbutus has an ongoing drug discovery and development program directed to identifying orally active agents for treating coronaviruses (including COVID-19). For more information, visit http://www.arbutusbio.com.

About Qilu Pharmaceutical

Qilu Pharmaceutical is a leading vertically integrated pharmaceutical company focused on discovering, developing, manufacturing and commercializing innovative medicines. With a diverse pipeline of novel therapeutics, 10 manufacturing sites and more than 23,000 employees worldwide, Qilu is dedicated to transforming scientific innovation by internal R&D across 5 R&D platforms based in the US (Seattle WA, Boston MA, San Francisco CA) and China (Shanghai, Jinan), and external partnership globally into healthcare solutions to address unmet medical needs. To date, Qilu has launched 200+ products with 30+ products "First to launch" in China and 3 products "D181 launch" in US with approximately US$4.2 billion sales revenue in 2020. For more information, please visit http://en.qilu-pharma.com.

Forward-Looking Statements and Information

This press release contains forward-looking statements within the meaning of the Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and forward-looking information within the meaning of Canadian securities laws (collectively, forward-looking statements). Forward-looking statements in this press release include statements about our future development plans for our product candidates; the expected cost, timing and results of our clinical development plans and clinical trials with respect to our product candidates; our expectations and goals for our collaboration with Qilu Pharmaceutical and any potential benefits related thereto; and the potential for our product candidates to achieve success in clinical trials.

With respect to the forward-looking statements contained in this press release, Arbutus has made numerous assumptions regarding, among other things: the effectiveness and timeliness of preclinical studies and clinical trials, and the usefulness of the data; the timeliness of regulatory approvals; the continued demand for Arbutus assets; and the stability of economic and market conditions. While Arbutus considers these assumptions to be reasonable, these assumptions are inherently subject to significant business, economic, competitive, market and social uncertainties and contingencies, including uncertainties and contingencies related to the ongoing COVID-19 pandemic.

Additionally, there are known and unknown risk factors which could cause Arbutus actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements contained herein. Known risk factors include, among others: anticipated pre-clinical studies and clinical trials may be more costly or take longer to complete than anticipated, may never be initiated or completed, or may not generate results that warrant future development of the tested product candidate; Arbutus may elect to change its strategy regarding its product candidates and clinical development activities; Arbutus may not receive the necessary regulatory approvals for the clinical development of Arbutus products; economic and market conditions may worsen; Arbutus and its collaborators may never realize the expected benefits of the collaborations; market shifts may require a change in strategic focus; and the ongoing COVID-19 pandemic could significantly disrupt Arbutus clinical development programs.

A more complete discussion of the risks and uncertainties facing Arbutus appears in Arbutus Annual Report on Form 10-K, Arbutus Quarterly Reports on Form 10-Q and Arbutus continuous and periodic disclosure filings, which are available at http://www.sedar.com and at http://www.sec.gov. All forward-looking statements herein are qualified in their entirety by this cautionary statement, and Arbutus disclaims any obligation to revise or update any such forward-looking statements or to publicly announce the result of any revisions to any of the forward-looking statements contained herein to reflect future results, events or developments, except as required by law.

Contact Information

Investors and Media

William H. CollierPresident and CEOPhone: 267-469-0914Email:ir@arbutusbio.com

Lisa M. CaperelliVice President, Investor RelationsPhone: 215-206-1822Email: lcaperelli@arbutusbio.com

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Arbutus and Qilu Pharmaceutical Enter into an Exclusive Licensing Agreement and Strategic Partnership to Develop and Commercialize AB-729 in mainland...

International regatta to be held between Jan 13 and 16, 2022 – Macau Business

The 2022 MGM Macao International Regatta has been scheduled to take place between January 13 and 16, 2022 with 37 teams from China and around the world competing for three championships.

The event is being organized by the Sports Bureau, Ursa Major Sailing Event Management, the Marine and Water Bureau and the Macau Sailing Association, with MGM China as its title sponsor.

The regattawill comprise three competitions the Guangdong-Hong Kong-Macao Greater Bay Area Cup Regatta (IRC), Macao Cup International Regatta (Beneteau First 40.7) unified design group and theInternational Catamaran Invitational (Hobie16) unified design group.

The Guangdong-Hong Kong-Macao Greater Bay Area Cup Regatta and the Macao Cup International Regatta will bring together 22 teams from China and various countries competing at the waters off south of Hac Sa Beach.

Meanwhile, 15 sailing teams that participated in theInternational Catamaran Invitational (Hobie16) unified design group, will compete for the championship at the waters south of the Inner Harbour Channel off the Macau Science Center.

Ancillary activities, such as fleet parade, photo competition, demonstration of sailing boats and parent-child workshop will also be held.

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International regatta to be held between Jan 13 and 16, 2022 - Macau Business

Gov’t reclaims 23,324 sqm land in Taipa – Macau Business

Macau authorities today (Monday) cleared out and recovered a 23,324 square meters land plot next to the Va Nam Industrial Building on Avenida Olmpica da Taipa.

The land recovered in this action was divided in two, with one 19,620 square meter section having had its land concession declared as expired, and a 3,704 square meters illegally occupied land plot.

The Land, Public Works and Transport Bureau (DSSOPT) recently issued an eviction notice to interested parties from the expired land, requiring them to vacate it and return it within the stipulated period.

At the same time, a public notice was also published, with the aim of starting the procedures for evicting and evicting the land that was illegally occupied. Those interested in the expired land had already signed a written declaration and returned most of the land to the Macao SAR Government, however, a small part was still occupied by other people, the department noted.

After the deadlines for vacating and evicting the two parts of the land in question, the government carried out a joint interdepartmental action to vacate and recover the entire land, having closed it and posted a notice to prevent any further illegal occupation.

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Gov't reclaims 23,324 sqm land in Taipa - Macau Business

Brother fears Assange may not survive US prosecution – Macau Business

Julian Assanges brother said Monday he feared the Wikileaks publisher would not survive the United States attempts to prosecute him after his fiancee revealed he had suffered a mini-stroke.

Gabriel Shipton was among about 30 people, including Pink Floyds Roger Waters and actress Susan Sarandon, to rally in support of Assange outside the British consulate in New York.

The protest came a day after Assanges fiancee Stella Moris said Assange had suffered a mini-stroke in late October, on the first day of a US government appeal against a ruling blocking his removal.

The demonstrators were protesting against a decision on Friday by British appeals judges to overturn the ruling after accepting US government assurances Assange would receive appropriate treatment and not be held in punishing isolation in custody.

Very worried about it, Shipton told AFP. This hanging over Julians head just increases the pressure on him now.

So we live in fear that he wont make it through this or that he will die basically, during this process, he added.

The United States wants to put Assange on trial for WikiLeaks 2010 publication of thousands of top-secret military documents about the US wars in Afghanistan and Iraq.

Assanges lawyers have previously raised concerns about the effects of his lengthy incarceration on his physical and mental health in a bid to halt the extradition.

Assange spent seven years in Ecuadors London embassy until 2019, after jumping bail in connection with sexual assault allegations in Sweden.

He was then jailed for 50 weeks for breaching bail in that case, which was later dropped, but detained ever since on the grounds he was a flight risk.

Sarandon told Assange supporters that no matter what you think of Julian Assange, his case was about journalism that just isnt about entertainment.

(It) has to do with having an informed public because once this goes, were really dead, she said.

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Brother fears Assange may not survive US prosecution - Macau Business

Portugal: Country welcomes 273 Afghans, most with music, artistic careers – Macau Business

The Prime Minister said that the country had today received 273 Afghan citizens on Monday, most of them with musical and artistic careers, following an operation in conjunction with friends of the National Music Institute of Afghanistan.

This new reception by Portugal of Afghan citizens was disclosed by Antnio Costa on his official Twitter account.

It is with great joy and a spirit of international solidarity that we receive 273 Afghan citizens in Portugal today, in an operation in conjunction with [friends] of the National Music Institute of Afghanistan (ANIM), he wrote.

In his message, the prime minister said they are students, young women and men, with their direct relatives, including siblings, who will have the opportunity to live and resume their studies in Portugal.

In addition to the reception, which honours us greatly, we will guarantee these people health care, education and social integration, Antnio Costa added

For the Prime Minister, these young people will thus be able to fulfil their dream of a musical and artistic career in freedom, peace and security.

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Portugal: Country welcomes 273 Afghans, most with music, artistic careers - Macau Business

Fundraising campaign mounted to improve treatment for bike crash victim – Macau Daily Times

The workplace and school of the recent heavy motorbike crash victim are putting out a call on several social media platforms for public donations to facilitate a higher level of medical treatment.

Last Friday, the victim was riding his heavy motorbike in the New Urban Zone A when a concrete mixer truck allegedly failed to give way as required by traffic signs.

He was not breathing and did not have a heartbeat when he arrived at the hospital, but was resuscitated by medical staff. He is now receiving treatment in the ICU of Kiang Wu Hospital.

A social media post stated that the hospital medical team acknowledged the need for external experts to perform a series of crucial operations on the victim to increase his odds of survival. However, his family may not be able to afford the cost of such operations.

As such, the City University of Macau Students Union and the Pou Tai Youth and Family Service Complex are co-leading a fund-raiser, hoping to obtain financial support for the victim and his family.

The Public Security Police Force is calling for witnesses of the accident. Information can be provided through 2837 4214. AL

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Fundraising campaign mounted to improve treatment for bike crash victim - Macau Daily Times

Elon Musk named Time magazine person of the year – Macau Business

Time magazine on Monday named Tesla chief and space entrepreneur Elon Musk as its person of the year 2021, citing his embodiment of the technological shifts but also troubling trends reshaping peoples lives.

Musk who overtook Amazon founder Jeff Bezos this year to become the worlds wealthiest person wields impact on Earth with his Tesla electric car company and beyond our planet with his SpaceX rockets.

Musks rise coincides with broader trends of which he and his fellow technology magnates are part cause and part effect, Time editor-in-chief Edward Felsenthal wrote.

Among those trends, Felsenthal listed the continuing decline of traditional institutions in favor of individuals; government dysfunction that has delivered more power and responsibility to business and chasms of wealth and opportunity.

Time editors have previously defined the title which last year went to President Joe Biden and Vice President Kamala Harris as going to people who embodied what was important about the year, for better or for worse.

In October, Musks electric car companys valuation soared above a trillion dollars, and SpaceX has teamed up with US space agency NASA to launch various missions including a test run of protecting Earth from an asteroid.

The brash South African-born 50-year-old has seen his wealth soar during the pandemic to over $250 billion, according to Forbes real-time billionaires list.

He has also courted controversy with his provocative Twitter feed that can attack, joke and provoke including a poll in November asking Twitter whether he should sell a 10 percent share of his Tesla stock.

Felsenthal noted Musks provocative vision is accompanied by a persona which is a blunt instrument that often seems to revel in division and aggressive mockery as he gives the world access to his id through social media.

Musk has appeared ever-present in American culture in recent years, amassing66 million Twitter followers and guest-hosting the famed late-night comedy show Saturday Night Live in May.

Musk speaks ambitiously about his interest in colonizing Mars, and plans orbital flights next year as part of SpaceXs planned American return to the Moon.

The goal overall has been to make life multi-planetary and enable humanity to become a spacefaring civilization, Musk told Time in an interview released with the Person of the Year announcement.

SpaceX is starting a program to take CO2 out of atmosphere & turn it into rocket fuel. Please join if interested, he tweeted later Monday, in an announcement that was as eye-catching as it was short of detail.

Musk has also been known to move markets and the value of cryptocurrencies with a single tweet, but his main terrestrial influence for now is with his electric vehicles.

Our intent with Tesla was always that we would serve as an example to the car industry, and hope that they also make electric cars so that we can accelerate the transition to sustainable energy, Musk told Time.

Time notes that in an earlier era interplanetary travel was a collective undertaking that leaders used to rally their nations, but that increasingly private companies are involved.

To Musk, that is progress, steering capital allocation away from the government to those who will be good stewards of it, Felsenthal wrote.

To others, it is testament to capitalisms failings as staggeringly wealthy, mostly white men play by their own rules while much of society gets left behind, he added.

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Elon Musk named Time magazine person of the year - Macau Business

Five injured as roofing collapses on Galaxy Macau Phase 3 construction site – IAG – Inside Asian Gaming

Five workers were injured on Saturday after a section of roofing in Galaxy Macaus Phase 3 development collapsed.

According to information released by Macaus Labour Affairs Bureau (DSAL), contractors have been ordered to cease all work in the area while the cause of the accident is investigated. DSAL said the accident may involve engineering design or engineering quality issues.

The five injured workers are all believed to have been working underneath the section of roofing when it collapsed on Saturday morning. They were transported to hospital where two of the workers remain for observation.

In a statement, Galaxy Entertainment Group, the owner and operator ofGalaxy Macau, said it was deeply concerned about the incident.

After learning about this incident, we have immediately reported it to related government departments, and five injured workers were transported to the hospital and representatives have been assigned to follow up and provide necessary assistance, GEG said.

As of now, three minor injured workers have been discharged from the hospital while two workers remain in the hospital for further observation.

GEG would like to take this opportunity to send our most sincere regards to the related workers. We have also requested the contractor to carry out a thorough investigation on the glass chandelier installation related to the incident.

As the case is currently under investigation, we have no further information to provide.

DSAL published a number of images of the collapsed roofing on Saturday, however GEG has disputed the authenticity of video footage circulating on social media over the weekend alleging to show the aftermath of the incident. Inside Asian Gaming has viewed some of these videos but has not been able to verify their source or accuracy.

We have learned that there was a video being circulated on social media that displays inaccurate content and therefore we would like to take the opportunity to clarify that the video has no relation with the incident, GEG said.GEG reserves the right to take appropriate action against that.

With work temporarily halted, DSAL noted that, according to Decree No. 44/91/M, contractors are obliged to ensure a safe working environment on the site and the operation of facilities, and to supervise workers in accordance with construction safety procedures to protect the lives of workers.

The Labour Bureau will continue to strengthen the supervision of the occupational safety and health status of construction sites. If there is an occupational safety and health violation, it will be dealt with in accordance with the law.

Galaxy Macau Phase 3 is due for completion in 2022, adding a number of new hotels, more gaming and retail space and the Galaxy International Convention Center.

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Five injured as roofing collapses on Galaxy Macau Phase 3 construction site - IAG - Inside Asian Gaming

A Tale of Two Sin Cities – The Motley Fool

Reopening from a worldwide pandemic was always going to be a risky bet for Las Vegas and Macau, the world's two largest gambling hubs. New...

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Reopening from a worldwide pandemic was always going to be a risky bet for Las Vegas and Macau, the world's two largest gambling hubs. New government data released on Monday shows that one city's roll has come up snake eyes, while the other is cashing in more chips than ever.

In Macau, the Chinese gambling Mecca, games of chance accounted for 80% of the government's tax income and 55.5% of the city's GDP before the pandemic hit. Nowadays, the go-for-broke mentality is just, well, broke.

Xi's Gamble: Covid resurgences in South Asia and the looming prospect of a government crackdown on casinos floated by China's government in September after earlier and massively disruptive interventions in tech and real estate have kept worrying gamblers on the sidelines:

Viva Las Vegas: But then there's Vegas, where high vaccination rates and pent up demand has the city playing a historically hot hand. Casinos on the Strip collected a record $2.1 billion in gambling revenue in the third quarter, the Nevada Gaming Control Board reported last week. The previous record was $1.8 billion in the fourth quarter of 2006.

Vegas' citywide gambling revenue is up 0.6% this year over pre-pandemic 2019. Revenues hit $604.6 million in September, a 9.9% increase over September 2019.

Now, if we could just get Elvis back.

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A Tale of Two Sin Cities - The Motley Fool

Konstantin Bessmertny | Exhibition showcases art that transports viewers to another reality – Macau Daily Times

With the pandemic causing the closure of borders and mandatory quarantine once more returning to the city, the yearning to voyage has been intensified.Macau-based Russian artist Konstantin Bessmertny, who has been fixture on the Macau art scene since 1992, had titled his ongoing art exhibition, Voyage 2021, a conceit that plays on social conditions whereby staying put in a place has become the norm.Voyage 2021 invites the public to see a different reality through the eyes of the artist. Although the exhibition does not travel to different places it does allow the public to travel in the same space: exploring different scenarios at different timelines.Speaking to the Times, Bessmertny expressed his passion for creating different narratives in a series of layers creating another reality in the mindset of the viewers.It is the duty of the artist to create his own reality, and people believe or are comfortable or uncomfortable but at least its another statement, said the artist.

The ongoing exhibition features pieces which date back in 1996, large-scale artworks which were part of the Art Biennale, and few which were inspired by his recent stay at Koh Samui: a trip Bessmertny made before staying put in Macau, since undergoing quarantine is not something that can be repeated.The arts industry is one of many industries that have been devastated amid the ongoing pandemic given that Covid-19 cases in the region have led to shutdowns of public cultural spaces in line with the governments aim to deter the spread of the virus.The last shut-down occurred in September, when the government closed its cultural venues and cancel various arts and cultural activities due to the string of cases that were discovered.During the peak of the pandemic early last year, the government also shut down public venues, and only gradually reopened them. This meant that different kinds of artistic performances and exhibitions were either cancelled or postponed.For Bessmertny, having had a significant number of solo exhibitions in Europe and Asia, this years exhibition is to keep myself in shape.The Art Biennale exhibition was half of the time closed [due to the pandemic]. People like to have real experience now. This is the second year [were in the pandemic] and Im here to keep myself in shape, said the artist.

Close to impossibleLocal artists particularly emerging ones may already have had difficult time holding their own exhibitions prior the pandemic. Now this is an even greater hurdle.According to Bessmertny, Macau is one of the best places to create art, citing support and resources provided by the government.However, to make a sustainable living out of merely producing artworks and showcasing them is another question that could frankly be answered as close to impossible.Its close to impossible to build it up as sustainable profession. [It will be] close to impossible to survive, he said.In the pop culture and in the winner takes all economy, only a few survive. Its sad to say but [with] the ratio [of artists and general public], its quite difficult. How many artists does Macau need? Bessmertny asked.In his view, an artist should ideally hold a solo exhibition in Macau only once in three to five years.If you exhibit three times a year, its a disaster. You overproduce, you overexpose and the effect is negative, the artist explained.Bessmertny said that the plans of emerging artists who are moving to Hong Kong in the hopes that there are more opportunities there, are unrealistic, since there already are lot of younger artists in Hong Kong who are also trying to survive.

Next project: Macau historyBessmertny is currently contemplating a new project that tells the history of Macau. Although two artworks related to this theme are currently showcased at Voyage 2021, this time the artworks would be installations done created according to a Japanese technique.Its about what Praia Grande looked like in the 1600s, prior the arrival of the Portuguese. Im bringing justice to historical events because there were no paintings made at the time, he explained.The artworks are currently on display at Clube Militar de Macau until November 6.

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Konstantin Bessmertny | Exhibition showcases art that transports viewers to another reality - Macau Daily Times

Company suspected of declaring false workers to receive subsidies being probed – Macau Business

Authorities are investigating a company suspected of providing false data about local workers to the Financial Services Bureau and the Social Security Fund, in order to improperly receive subsidies to support the fight against the pandemic, the Commission Against Corruption announced on announced on Monday.

The company in question provides maintenance and repair services for the building of the Hong Kong-Zhuhai-Macao Bridge Border Post, CCAC said in a statement.

During the investigation, the CCAC verified that the referred company declared, with the relevant services, that it had hired 24 local workers, but six of the declared workers had a record of abnormal border movements and rarely stayed in Macau, you can read. if in the note.

There was even the case of someone who left Macau in 2015 and never came back in, pointed out the CCAC.

Some workers confessed that they had never worked at the company or that they had not received any salary, stating that the payment of contributions to Social Security was only to receive the pension for elderly people granted by the Government in the future, the organization also said. to combat corruption.

For the CCAC, there are strong indications that the workers in question are simulated workers, having the body denounced the case to the Public Ministry, on suspicion of crime of falsifying documents.

The CCAC also suspects that the workers in question have improperly received pecuniary support to combat the epidemic, granted by the Government of the Macao Special Administrative Region].

Last year, each local worker in the aforementioned company received 15,000 patacas [1,605 euros] as pecuniary support to combat the epidemic, reported the CCAC.

The anti-graft body reported this case of undue receipt of amounts by these workers to the Financial Services Bureau(DSF) .

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Company suspected of declaring false workers to receive subsidies being probed - Macau Business

Israel grandfather appeals ruling returning child to Italy – Macau Business

The grandfather of a boy whose parents died in an Italian cable car crash appealed Monday the Israeli court ruling returning the child to family in Italy, a spokesman said.

The battle for custody of Eitan Biran, the sole survivor of the May accident that killed 14 people, has captured headlines since his maternal grandfather, Shmulik Peleg, brought him to Israel on a private jet last month.

Peleg has insisted that he drove Eitan from Italy to Switzerland before jetting him back to Israel instead of returning him to paternal aunt Aya Biran, who lives in northern Italy because Eitans late parents wanted him to be raised in the Jewish state.

But Peleg has become the subject of a kidnapping probe by Italian prosecutors, and Israeli police questioned him over those allegations last month.

A family court in Tel Aviv on October 25 recognised an Italian judgement that established Biran as a legitimate guardian, and said Peleg had unlawfully removed the boy from his aunts care.

The court ordered the return of the minor to his usual place of residence in Italy.

A spokesman for Peleg said he filed an appeal Monday to the district court, saying the family tribunal did not address the tragic circumstances at hand and ignored the unilateral actions of (Biran), who allegedly acted in deceit behind the backs of the grieving Peleg family to win custody.

Peleg also accused Biran of not upholding the temporary custody arrangements agreed after the child was brought to Israel.

There is no reason that the debate over where Eitan spends his life should take place while he is in Italy, the spokesman said in a statement, adding that most family members from both sides lived in Israel.

Eitanand his parents, AmitBiranand Tal Peleg, had been living in Italy, where AmitBiranwas studying medicine, together with their other child, Tom, who also died in the crash.

Eitan suffered severe chest and abdominal injuries and spent a week in intensive care after the May accident, that occurred when the cable snapped on the aerial tram bringing weekend visitors to the top of the Piedmont regions Mottarone mountain.

The accident was one of Italys worst in over two decades.

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Israel grandfather appeals ruling returning child to Italy - Macau Business

Special Report – Taiwan: the other issue – Macau Business

20 years in the WTO is a milestone achieved not just by Mainland China, but Taiwan, too.

MB October 2021 Special Report | China attheWTO

The WTO formally approved Taiwan for Membership in November 2001.

Taiwan had been negotiating for entry into the WTO for more than 12 years. However, as Professor Andrew Christie Papadimos, International Business and Economics, School of Business, Australian Catholic University, states, Taiwans main obstacle was that it had to accede to Chinese demands that China be allowed entry first, even though negotiations and the terms of Taiwans accession to the WTO were effectively completed two years before.

Beijings argument was that despite Taiwans status as a separate territory from Mainland China, it is a part of China that will eventually be reunited with the mainland. So, to accommodate Beijings view, within the WTO Taiwan is known as Chinese Taipei and it entered the WTO as the Separate Customs Territory of Taiwan, Penghu, Kinmen and Matsu.

In contrast to other international organizations, the WTO does not require its members to be states, and it was this constitutional feature that allowed Taiwan to join the WTO. 20 years later, the WTO is now the only major international organization in which Taiwan can participate as a full member.

Professor Papadimos, author of the bookChina and Taiwans WTO Experiences, notes that despite the tension between China and Taiwan, both areas have been forced to adopt WTO rules stipulating that all Members must treat each others goods and services equally. He adds, however, that because the tensions between China and Taiwan are a zero-sum game by nature, where there will ultimately only be one winner and one loser, the WTO will find it difficult to ease political tensions between the two sides.

Political tensions but also opportunities.

To take stock of these 20 years and understand whether belonging to the WTO is more important from a geostrategic point of view than a commercial one,Macau Businesssought the opinion of one of Taiwans leading experts, Professor Roy Lee, Senior Deputy Executive Director, Taiwan WTO and RTA Centre, Chung-Hua Institution for Economic Research.

Commercial interest is equally significant, if not more. In particular, WTO membership facilitated the rapid development of Taiwans electronics industry, which before WTO accession had suffered from trade barriers in key export markets, Professor Lee replies.

Specifically, the WTOs Information Technology Agreement (ITA) held tariff rates at zero for a broad range of products, including semiconductors, desktop and laptop computers (and components), smart phones, display monitors and digital set-top-boxes. As ITA-covered products account for more than 50 per cent of Taiwans overall exports, the benefit for Taiwan is significant, he explains.

The ITA also offsets the economic impact of Taiwans exclusion from regional free-trade areas such as the Regional Comprehensive Economic Partnership (RCEP), since a majority (over 70 per cent on average) of Taiwans exports to RCEP members is already tariff free. Other sectors that have gained the most from WTO participation are solar PV components, automotive parts, and steel manufacturing, Professor Lee, also a member of the Advisory Committee to Taiwans Mainland Affairs Council, adds.

Professor Steve Charnovitz, George Washington University Law School, Washington DC, asserts that what Taiwans membership does do, however, is to establish some rule of law between Taiwan and China and to give Taiwan standing in an international tribunal should it wish to assert that China has violated WTO rules. The parallel memberships of Taiwan and China also provide a neutral international forum for those two governments to meet and negotiate if needed.

In particular, WTO membership facilitated the rapid development of Taiwans electronics industry, which before WTO accession had suffered from trade barriers in key export markets , Roy Lee

As in other sectors of Taiwans life, the Taipei Governments biggest ally in its accession to the WTO was the United States.

Two decades later, Washington remains in the front row.

Recently Washington announced its intention to elevate Taiwans status, as the two sides revived a Trade and Investment Framework Agreement (TIFA) that was signed in 1994, but essentially moribund since then, according to Joseph Bosco, who served as China Country Desk Officer in the Office of the Secretary of Defense from 2005 to 2006. Now a member of the advisory board of the Global Taiwan Institute, Bosco adds, Beijing strongly objected to the Trump administrations growing ties with Taiwan and warned that Washington would have to choose which trade partner was more important to its interests. The political impasse over Taiwans economic status was reminiscent of the years-long delay that held up its accession to the World Trade Organization in the 1990s.

What are the possible consequences of this US decision?

Cross-Strait relations, insofar as the economic aspect is concerned, are decided mainly by the architecture of the global supply network, Roy Lee tellsMacau Business. For instance, the semiconductors exported to China by US fabless [non-fabricating] chip firms such as QUALCOMM, AMD and Apple are manufactured in Taiwan. Those chips are added to laptop computers, iPhones and Chinese smart phones, which are assembled in China, in many cases by Taiwanese companies (e.g. Foxconn) with premises in China, he continues.

This indicates that the major factors affecting the TaiwanChina economic relationship are actually associated with the USChina de-coupling process, rather than the TIFA, Professor Lee says, adding that while an improved Taiwan-US relationship at government level is certainly a good sign, commercial interest is still the dominating factor for the private sector at the end of the day.

His prediction: In summary, we expect to see a decline of outbound investment from Taiwan to China because of the supply network re-configuration, yet bilateral trade will remain strong for the time being.

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Special Report - Taiwan: the other issue - Macau Business