CONDUCTIVE EDUCATION – THE MOVEMENT CENTRE OF MANITOBA – OUR STORY (Web Version) – Video

http://www.youtube.com/watch?v=qAIg47bHnqQ

CONDUCTIVE EDUCATION – THE MOVEMENT CENTRE OF MANITOBA – OUR STORY (Web Version)
In Canada – Text MOVE to 45678 to donate $5 To The Movement Centre of Manitoba BECAUSE EVERYONE DESERVES TO REACH THEIR FULL POTENTIAL The Movement Centre of Manitoba is a registered not for profit organization that utilizes a unique and intensive rehabilitation program called “Conductive Education” or CE. CE helps children and adults with mobility disorders such as cerebral palsy, stroke, brain injury, multiple sclerosis and Parkinson #39;s disease gain or regain mobility, functional independence and confidence. The Movement Centre of Manitoba is the only facility in the province and only one of three not for profit facilities in Canada that provides Conductive Education rehabilitation programs. Conductive Education – Teaching Independence – Transforming Lives. For more information please visit http://www.movementcentre.ca Written Produced by Nancy Gregory (Media 1 Productions) 2012.From:Media1productionswpgViews:37 0ratingsTime:06:24More inNonprofits Activism

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CONDUCTIVE EDUCATION – THE MOVEMENT CENTRE OF MANITOBA – OUR STORY (Web Version) – Video

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http://www.longevitymedicine.tv/conductive-education-the-movement-centre-of-manitoba-our-story-web-version-video/

TUDCA Tauroursodeoxycholic Acid – Video

http://www.youtube.com/watch?v=2j5Z1hGq2iU

TUDCA Tauroursodeoxycholic Acid
Buy from Amazon US redirect.viglink.com?key=f341fd9454fc162be8b38d504acbd4e1 out=http%3A%2F%2Fwww%2Eamazon%2Ecom%2Fexec%2Fobidos%2FASIN%2FB008D9MA7G%2Fhealth%5Fhope%2D20 Product Description TUDCA Tauroursodeoxycholic Acid TUDCO, or Tauroursodeoxycholic Acid is a type of acid found in bile. It has been used for hundreds of years in Chinese medicine to relieve spasms, reduce fever and improve visual acuity. One of the most popular benefits of TUDCA is its use as a liver protector. This can be beneficial to people who already have liver damage, due to cirrhosis, alcohol abuse, or taking androgenic substances. In some cases, research may indicate that TUDCA helps treat chronic hepatitis. It is also a great addition to a post cycle therapy stack. Research has also indicated that this supplement may even help with other conditions. This includes potential benefits for those suffering from Huntington #39;s disease, Parkinson #39;s disease or those who are recovering from a stroke. Further research also suggests that TUDCA may help to protect the eyes, especially from degenerative disorders of the retina. Further studies have indicated that taking this supplement may lead to improved serum lipid (types of fat cells) levels. Disclaimer Hope is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon. Amazon and the Amazon logo are trademarks of Amazon …From:jeanine guerinViews:0 0ratingsTime:00:56More inScience Technology

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TUDCA Tauroursodeoxycholic Acid – Video

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http://www.longevitymedicine.tv/tudca-tauroursodeoxycholic-acid-video/

Healthy Origins CoQ10 – Video

http://www.youtube.com/watch?v=ZfLMxvmmnJ0

Healthy Origins CoQ10
Buy from Amazon US redirect.viglink.com?key=f341fd9454fc162be8b38d504acbd4e1 out=http%3A%2F%2Fwww%2Eamazon%2Ecom%2Fexec%2Fobidos%2FASIN%2FB001E0SG8S%2Fhealth%5Fhope%2D20 Product Description Healthy Origins CoQ10 Healthy Origins CoQ-10 Gels (Ubiquinone) is a naturally occurring substance that facilitates the production of cellular energy. In every cell in your body, there are small “engines” called mitochondria. Ninety-five percent of the total energy created within the body comes from these mitochondria, and none of it can take place without CoQ10. Our 100 % natural (trans-isomer) CoEnzyme Q10 is produced exclusively through a yeast fermentation process and is pharmaceutical grade, the highest quality available. Kaneka Q10 is manufactured either in Japan or in Pasadena, Texas (the only CoQ10 raw material made in the USA).* Reviews as follows Anna, December 27, 2007 From New York: “Excellent quality, easy to swallow, affordabale. My mother has Parkinson #39;s disease, and her neurologist suggested this product as a supplement for her prescription medication. She #39;s been using this porduct for over 2 years now, and the progression of the disease seems to have slowed. I used to have gum disease, but using this product has healed it completely. And my skin is in the best shape it has ever been.” From Florida: “5 years ago I had high blood pressure and high cholesterol. Dr. put me on 400mg of Co-Q10 along with 3000mg of Omega-3 2x #39;s per day. Today, my BP is normal and Cholesterol …From:virgen crispViews:0 0ratingsTime:00:56More inScience Technology

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Healthy Origins CoQ10 – Video

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http://www.longevitymedicine.tv/healthy-origins-coq10-video/

Mucuna Pruriens – Video

http://www.youtube.com/watch?v=ovGxytyV-io

Mucuna Pruriens
Buy from Amazon US redirect.viglink.com?key=f341fd9454fc162be8b38d504acbd4e1 out=http%3A%2F%2Fwww%2Eamazon%2Ecom%2Fexec%2Fobidos%2FASIN%2FB007PBQNDA%2Fhealth%5Fhope%2D20 Product Description Mucuna Pruriens Mucuna Pruriens 99% L Dopa is a 99% pure formulation of L-Dopa. Also called Levodopa, this is an amino acid precursor of dopamine which is able to cross the blood brain barrier and essential turn into dopamine. Extracted from the seeds of the Mucuna Pruriens plant, this is the purest form on the market. Most other formulations contain between 15 and 50%. Once L-Dopa crosses the blood brain barrier it acts as a precursor for dopamine and adrenaline. This leads to some rather incredible beneficial effects related to mood, cognition, disease treatment and even some sexual benefits. Dopamine is believed to help with mood, movement and sexuality. You will notice an effect on your mood and cognition. A general feeling of well-being ordinarily occurs, along with a positive mood and mental alertness. Proper brain functioning and enhanced cognition are supported. Since 1961, L-Dopa has been the most effective treatment for Parkinson #39;s disease. It is most effective against nausea, rigidity and slowness these patients usually suffer. Several studies have also indicated that this supplement may enhance the production of HGH (human growth hormone) and lead to improved sexual performance as well. It is thought to increase testosterone production and protect sperm from oxidative …From:mikaela gomesViews:0 0ratingsTime:00:58More inScience Technology

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Mucuna Pruriens – Video

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Investigating the Mechanisms of Cellular Senescence

Senescent cells are those that have left the cell cycle without being destroyed, either by the immune system or by one of the processes of programmed cell death. They remain active, however, exhibiting what is termed a senescence-associated secretory phenotype (SASP): these cells secrete all sorts of chemical signals that prove harmful to surrounding tissues and the body as a whole – through promotion of chronic inflammation, for example.

The number of senescent cells in tissue grows with age, and this increase in numbers is one of the root causes of aging. Researchers have demonstrated benefits in mice through destroying senescent cells without harming other cells. Regular targeted destruction of senescent cells could be the basis for therapies that remove this contribution to degenerative aging.

Any other approach would require understanding more about SASP and how to control or reverse the unpleasant effects of senescence – and here is an example of this sort of research, aimed at identifying controlling mechanisms with an eye to building therapies to reduce SASP:

With advancing age, senescent cells accumulate in tissues and the SASP-elicited proinflammatory state is believed to have a complex influence on age-related conditions. For example, two major SASP factors, IL-6 and IL-8, together with other SASP factors, attract immune cells to the tissue in which senescent cells reside; depending on the tissue context, this immune surveillance can promote processes such as wound healing, the resolution of fibrosis, and tumor regression. At the same time, SASP factors can compromise the integrity of the ECM, thus facilitating cancer cell migration. In addition, the systemic proinflammatory phenotype seen in the elderly is believed to affect a broad range of age-related pathologies, including diabetes, cancer, neurodegeneration and cardiovascular disease and contributes to an age-related decline of the adaptive immune system (immunosenescence).

Despite the great potential impact of the SASP on the biology of senescence and aging, the mechanisms that regulate SASP are poorly understood. … Here, we report the identification of NF90 as an RNA-binding protein that binds to numerous mRNAs encoding SASP factors (collectively named SASP mRNAs) and coordinately influences their post-transcriptional fate in a senescence-dependent manner.

In young, early-passage, proliferating fibroblasts, high NF90 levels contributed to the repression of SASP factor production. This repression was elicited mainly via reduction in SASP factor translation … By contrast, in senescent cells NF90 levels were markedly reduced, which allowed increased expression of numerous SASP factors. Our results are consistent with a role for NF90 as a coordinator of the inhibition of SASP factor production in early-passage, proliferating fibroblasts; in senescent cells, the lower levels of NF90 lead to SASP de-repression, permitting higher expression of SASP factors

Link: http://impactaging.com/papers/v4/n10/full/100497.html

Source:
http://www.fightaging.org/archives/2012/11/investigating-the-mechanisms-of-cellular-senescence.php

Source:
http://www.longevitymedicine.tv/investigating-the-mechanisms-of-cellular-senescence/

A Possible Metabolic Signature of Biological Age in Mice

A low-cost, reliable method of measuring biological age is greatly sought after by the research community. People and laboratory animals age at different rates – by which I mean that they accumulate damage and changes characteristic of aging at different rates. Thus two individuals of the same species and same chronological age might have different biological ages thanks to life style, environment, access to medicine, and so forth.

Some interventions, such as calorie restriction, can slow the pace at which an individual ages, but measuring this slowing is a challenging process. Biological age is a simple concept at the high level, but finding a quick and reliable way to actually measure it has yet to happen. Thus while researchers would like to have rapid answers as to how effective any given method of slowing aging might be, they must wait and run long-lasting studies. The bottom line measure for any slowing of aging is to wait for the individuals in question to live out their lives and thus measure by effect on life span. Even in short-lived mice this can require years and thus a great deal of money. In longer-lived animals, ourselves included, it is simply impractical to run the necessary studies.

When it comes to the forthcoming generation of therapies capable of limited rejuvenation – by repairing some of the damage that causes degenerative aging – the situation is much the same, as is the need for a quick and easy measure of biological age. A therapy that actually produces some degree of rejuvenation should make a laboratory animal biologically younger than peers with the same chronological age. But how to measure that change without employing the lengthy and expensive wait-and-see approach?

Given the present state of affairs, any quick measure of biological age will speed research, making it very much faster and cheaper to assess varied means of extending healthy life. Some experiments that would presently require a year or more could be conducted in a few weeks or months: apply the therapy and evaluate the resulting changes in measures of biological age.

Several lines of research look promising when it comes to yielding a way to reliably and consistently evaluate biological age. One involves measurement of DNA methylation levels, and despite initial setbacks it may yet prove possible to tease out a useful measure from changes in the dynamics of telomere length. There are others. Here, for example, is a recent paper in which researchers present a method based on measurement of metabolite levels:

A metabolic signature predicts biological age in mice

Our understanding of the mechanisms by which aging is produced is still very limited. Here, we have determined the sera metabolite profile of 117 wild-type mice of different genetic backgrounds ranging from 8-129 weeks of age. This has allowed us to define a robust metabolomic signature and a derived metabolomic score that reliably/accurately predicts the age of wild-type mice.

In the case of telomerase-deficient mice, which have a shortened lifespan, their metabolomic score predicts older ages than expected. Conversely, in the case of mice that over-express telomerase, their metabolic score corresponded to younger ages than expected.

Importantly, telomerase reactivation late in life by using a TERT based gene therapy recently described by us, significantly reverted the metabolic profile of old mice to that of younger mice … These results indicate that the metabolomic signature is associated to the biological age rather than to the chronological age. This constitutes one of the first aging-associated metabolomic signatures in a mammalian organism.

This might turn out to be an indirect measure of telomerase activity and little else, as over-specific matching is always a potential issue when searching for patterns in a large and complex system such as mammalian metabolism. Testing this metabolic signature against other means of accelerating or slowing aging in mice – such as calorie restriction – is thus one obvious next step.

Source:
http://www.fightaging.org/archives/2012/11/a-possible-metabolic-signature-of-biological-age-in-mice.php

Source:
http://www.longevitymedicine.tv/a-possible-metabolic-signature-of-biological-age-in-mice/

tes2 – Video

http://www.youtube.com/watch?v=f3gJgpLNk_w

tes2
Hi! Please take the time to view this short clip, and perhaps read the description posted below. Ate Tes is the focal person of the Persons with Disabilities Affairs Office in San Juan, Batangas. She was diagnosed with Parkinson #39;s Disease (a degenerative condition that restrains her movement unless she takes medication) at around 20 years old. At that time she was studying law in Ateneo but the nature of her condition prevented her from achieving this goal. For some time, she shut herself off from the outside world; but since a few years back and with the help of the people around her, she has started to gain new trust in herself. Just this year, she was chosen to be part of the First Community Based Rehabilitation World Congress to be held in India on November 26-28, 2012. This is great opportunity for her to be able to help empower and inspire others just as she was empowered. Unfortunately, financial situations are preventing her from being able to attend the congress–which is why the UP-CAMP CHDP Interns of 2012-2013 are reaching out to you. Please help us send Ate Tes to India by spreading the word, and if possible, sending donations. Any amount will really help us achieve this goal. You can contact us at 09151292327 for details regarding possible donation processes. Thank you and may the Lord bless you.From:upmsp2013Views:10 0ratingsTime:01:10More inNonprofits Activism

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tes2 – Video

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http://www.longevitymedicine.tv/tes2-video/

Long for this World

A brace of popular science books on gerontology and engineered longevity have been written in past years - one of the many signs that the field is growing in profile in the public eye, an important step on the way to obtaining funding for more rapid progress. Here the Village Voice notes an irreverent forthcoming addition to the portfolio. Per the article, we probably shouldn't take it seriously as anything but a sign of the times: "Along with the origin of life and the nature of consciousness, why and how we age is one of the weightiest questions out there. It's one Weiner tackles in his new book Long for This World, a brilliant and improbably funny look inside the mind-bending science of immortality ... These people are asking what makes us mortal. It's something everyone's curious about, whether they're scientists or not. ... Human life expectancy has doubled over the past 200 years, Weiner writes, thanks primarily to advancements in medicine. And while prominent gerontologists argue that we can expect another seven years fairly soon, the most fervent members of the field are gunning for the total eradication of death. Chief among the latter is Aubrey David Nicholas Jasper de Grey, Weiner's arch protagonist."

View the Article Under Discussion: http://www.villagevoice.com/2010-05-25/books/jonathan-weiner-follows-search-for-immortality/

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Common Fruits and Vegetable Varieties May Reduce the Risks of Commonly-fatal Lung Cancer

Simply by eating a wide variety of rich fruits and vegetables, Lung cancer risks can be easily reduced among smokers.

The world is dotted with over a billion cigarette smokers, all of which are at risk of developing certain types of cancer. In the United States, lung cancer is a dreaded fatal condition that accounts as the leading cause of cancer-related deaths, regardless of gender. Smokers are aware of the huge numbers associated with risks and fatalities. However, the addictive component of tobacco and cigarettes prevail in most instances.

Based on a recent study, cessation from smoking is still the most definite and proven way of reducing the risk of lung cancer, but another method may contribute to decreasing lung cancer risks effectively. It implies that if a smoker is yet to quit the habit, he can at least start with reducing lung cancer risks through eating a variety of fruits and vegetables.

Lung Cancer

All types of cancer are characterized by changes that occur in cells, which result in the cell’s physical and behavioral abnormality. This leads to lung cancer when the uncontrolled cell growth starts to take place in one or both longs.

The deviant cells continuously reproduce and divide, which thus lead to tumor formation, or lumps of tissue. Tumors intervene with the major lung activity of providing oxygen to the bloodstream, and may either be malignant or benign. If it is benign, the tumor remains in a single place and its growth is limited; while malignant tumors develop due to migrating cancer cells that spread to other body parts. Metastasis occurs when the malignant tumor grows and destroys other tissues.

Lung cancer is usually categorized into two main types: small-lung cancer and non-small lung cancer. Squamous cell carcinoma is classified under non-small cell lung cancers. Tumours that develop from squamous cells — cells that take the place of damaged cells in the bronchi’s lining — are often located in the lung’s central area and may possibly form cavities.

Squamous cell carcinoma is most often caused by smoking, and it accounts for approximately 30% of all cases of lung cancer.

The Research Breakthrough: Variety over Quantity

A wealthy line of research and evidence has already proven the significance of eating fruits and vegetables to maintain and improve health. However, the recent research added a new twist to the common “fruits and vegetables are beneficial for your health” notion. Published in Cancer Epidemiology, Biomarkers & Prevention, the study yielded findings that indicate the potential role of eating fruits and vegetables in reducing lung cancer risks among smokers.

It involved 450,000 Europeans and with 1,600 participants that were already diagnosed with lung cancer disease; along with 14 fruits and 26 vegetables that came as canned, fresh, and dried. Two particularly notable details were discovered: squamous cell carcinoma risk decreased through eating a variety of fruits and vegetables, regardless of quantity.

From the old “eat lots of fruits and vegetables”, a new perspective arose: Eat diverse kinds of fruits and vegetables.

The Wallin Land Grant Professor of Cancer Prevention at the University of Minnesota’s Masonic Cancer Center and a current member of Cancer Epidemiology Biomarkers & Prevention’s editorial board, Stephen Hecht, said that the study was one of the first to assess the importance of diversity over quantity for the prevention of cancer development.

Hecht further stated that the need for fruit variety stems from the fact that tobacco smoke has various cancer-inducing agents or carcinogens, all of which are intricately and complexly mixed. As such, reducing the risk of lung cancer warrants also a rich mixture of protective factors and agents, such as the diverse and healthy fruits and vegetables used in the study.

Smokers, the number of which consistently reaches an alarming scale worldwide, find it difficult to quit the smoking habit, despite exerting a large amount of effort into successfully leaving the cigarette behind. Hecht acknowledged the smoking statistics and smokers’ struggle, and commented that the new discovery showed how struggling smokers can, at least, potentially employ the protective factor found in a variety of fruits and vegetables.

Exploring Other Natural Protective Factors

The study that was earlier discussed further added to the attention and credibility that natural treatment remedies deserve. Fortunately, there are other natural protective factors and risk-reducing methods that are mostly beneficial and efficient. Furthermore, these are worthy of people’s choice, especially those who do not wish to incur more complications and side effects due to taking prescribed and chemical-filled drugs.

The following are some other natural preventive measures:

1. Avoid all forms of tobacco.

Of course, readers must be cautious of thinking that the recent study encourages smoking. The researchers added a disclaimer: Despite interesting study results, the only proven way of lung cancer risk reduction is through avoiding all forms of tobacco. As such, non-smokers must not smoke in the first place; occasional smokers should quit while they are yet to become addicted; and chronic smokers should at least strive to stop the habit now.

Tobacco smoke reportedly contains more than 60 known carcinogens. Because carcinogens interrupt the normal development and growth of cells, it enables cancer to initially take form. Quitting, then, is the best tactic in reducing lung cancer risks. Second-hand smoke — which is generally the exhaled smoke pipes, cigarettes, and cigars that people inhale — should also be avoided.

2. Stop Inhaling High Levels of Radon

If smoking is the leading cause of lung cancer, a second leading cause follows it: Radon. Approximately 22,000 fatalities due to lung cancer are significantly related to radon.

Radon is a radioactive gas that arises from normal uranium decay in the soil, which eventually spreads in the air. It is difficult to sense the presence of this gas through the 5 basic senses. Along with uranium’s quick decay, tiny radioactive particles are produced and diffused in the air. Inhalation of the said radioactive particles potentially damage lung cells. As such, frequent exposure to and inhalation of radon at high levels enable lung cancer to develop.

While the links are yet to be firmly established, statistics show that a combination of smoking and radon gas exposure heightens lung cancer risks, than when these risk factors operate separately.

With the given information, it is wise for people to test their homes for radon levels. Soil composition and proximity heightens radon levels indoors. There are several short-term and long-term testing devices available, all of which are relatively affordable. For further aid, people should consult their state or local radon official.

3. Physical activity for lung cancer prevention and improved survival rate

Given the wide array of benefits that physical activity and exercise provide, and the conditions that can be prevented, it is not surprising to note that lung cancer belongs to these fatal diseases. Furthermore, according to a 2007 study that was included in the Sixth Annual International Conference on Cancer Prevention of the American Association for Cancer Research, besides lung cancer prevention, exercise can improve the survival chances of those who are already diagnosed.

Sources
newsmaxhealth.com
aacr.org
intro: umm.edu
cancer.gov
cancer.about.com
medicinenet.com
theajcf.org

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Never Too Late to Exercise: the PROOF Study

Even at older ages, exercise is a still very important - as demonstrated by the degree to which it influences ongoing health in later stages of life, just as it does in earlier stages in life. "It is not sufficient simply to live longer. One of the current priorities for public health is to how to maintain good quality of life for longer. This has given rise to the concept of 'successful aging' generating a turning point in our thinking about aging, which is no longer seen as an inevitable decline. ... Physical activity has a pleiotropic effect and is a significant factor in successful aging. This study aims to quantify the relationship between the physical activity of a 65-year-old cohort and the level of life satisfaction and self-rated health 7 years later. A total of 988 questionnaires were sent by mail to a representative sample of healthy pensioners. Life satisfaction and health status were estimated on two visual analogical scales in answer to the following questions: (1) How would you estimate your state of health? and (2) Are you generally satisfied with your life? The level of physical activity was estimated using a questionnaire which enabled us to calculate: Daily energy expenditure (DEE) [and] VO2 peak. ... Energy spent in activity and VO2 peak estimated from DEE, measured at the age of 65, appear to be strong predictors of well-being 7 years later."

Link: http://dx.doi.org/10.1089/rej.2010.1101

Selection Effects and Longevity Genes

How is it possible for evolutionary selection to favor genetic variants beneficial in human old age, long after reproduction is impossible? An open access paper examines this question: "Evidence points towards the existence of a strong heritable component of human longevity. Around a quarter to a third of the variability of lifespan can be attributed to the action of genes. One of the best examples of a gene affecting survival in old age is the apolipoprotein E gene APOE. ... One of the major ideas in the evolutionary theory of ageing is the suggestion that, because the force of natural selection declines with age, alleles with deleterious effects seen only at older ages can reach higher frequencies than those that have their effects earlier in life. Therefore, if a gene exerts an effect only after the end of the reproductive phase of the lifespan it has been thought unlikely that it could have been subject to significant direct selection pressure ... It is often claimed that genes affecting health in old age, such as cardiovascular and Alzheimer diseases, are beyond the reach of natural selection. We show in a simulation study based on known genetic (apolipoprotein E) and non-genetic risk factors (gender, diet, smoking, alcohol, exercise) that, because there is a statistical distribution of ages at which these genes exert their influence on morbidity and mortality, the effects of selection are in fact non-negligible."

View the Article Under Discussion: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848859/

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Love Pistachios? Your Heart Does, Too!

Pistachios are a great way to start the day – because it protects the heart and lowers bad cholesterol.

Pistachios are well-loved nuts, not just in the United States but around the globe. We have even more reasons to love this health nut: researchers from Pennsylvania State University  concluded that pistachios are ideal for controlling cholesterol levels because it’s natural packed with nutrients and good fats which helps the cardiovascular system work more efficiently.

The study involved 28 respondents (adult males and females) who were given pistachios during the research period. The nuts had a marked effect on the LDL or bad cholesterol level of the test respondents.

Other benefits of pistachios

Pistachios are packed with lutein and other organic compounds that serve as anti-oxidants. Anti-oxidants reduce cell damage and further protects cells from the ravages of free radicals.

Coupled with the right diet and exercise, a heart-healthy meal plan consisting of pistachios, vegetables and lean meat can significantly contribute to decreasing cardiovascular problems and even cancer. It’s all about synergy – the components of a fitness plan must be synergistic with each other to work well.

In addition to being loaded with anti-oxidants, pistachio nuts are also great sources of vitamins and minerals. Minerals like iron, which are present in pistachios, are heart protectors. In the long term, eating foods similar to pistachios will enhance the protective effect of a heart-healthy diet.

Tips for lowering LDL cholesterol

1. As much as possible, stick to lean, white meats and avoid red meats. Red meats are packed with bad cholesterol (LDL) and only make things worse.

2. Moderate consumption of red wine (and other wines with resveratrol) may reduce LDL and protect your heart, too. Note that a small quantity of wine, drank regularly every week is sufficient. Do not overdo alcohol consumption.

3. Eat foods high in fiber like fruits, vegetables, grains and legumes

4.Cold water fishes packed with omega-3 fatty acids are also ideal in combating high cholesterol levels.

5. 42.5 grams of healthy nuts like pistachios and even walnuts can help lower your cholesterol over the long term.

Summary: Pistachios are a great way to start the day – because it protects the heart and lowers bad cholesterol.

Sources:
webmd.com
mayoclinic.com
cholesterol.about.com

Promoting Remyelination by Blocking Hyaluronidase

Myelin is the material sheathing axons in nerve cells. A number of conditions involve loss of myelin, such as multiple sclerosis (MS), but loss of myelin integrity occurs to a lesser degree for all of us as we age, and is thought to contribute to the characteristic cognitive decline of later years. Thus research into ways to regenerate myelin sheathing has broad potential application and is worth keeping an eye on:

We have identified a whole new target for drugs that might promote repair of the damaged brain in any disorder in which demyelination occurs. Any kind of therapy that can promote remyelination could be an absolute life-changer for the millions of people suffering from MS and other related disorders.

In 2005, [researchers] discovered that a sugar molecule, called hyaluronic acid, accumulates in areas of damage in the brains of humans and animals with demyelinating brain and spinal cord lesions. Their findings at the time [suggested] that hyaluronic acid itself prevented remyelination by preventing cells that form myelin from differentiating in areas of brain damage. The new study shows that the hyaluronic acid itself does not prevent the differentiation of myelin-forming cells. Rather, breakdown products generated by a specific enzyme that chews up hyaluronic acid – called a hyaluronidase – contribute to the remyelination failure.

This enzyme is highly elevated in MS patient brain lesions and in the nervous systems of animals with an MS-like disease. The research team [found] that by blocking hyaluronidase activity, they could promote myelin-forming cell differentiation and remyelination in the mice with the MS-like disease. Most significantly, the drug that blocked hyaluronidase activity led to improved nerve cell function. The next step is to develop drugs that specifically target this enzyme.

Link: http://www.sciencedaily.com/releases/2012/10/121031151611.htm

Source:
http://www.fightaging.org/archives/2012/11/promoting-remyelination-by-blocking-hyaluronidase.php

Source:
http://www.longevitymedicine.tv/promoting-remyelination-by-blocking-hyaluronidase/

Not All Longevity Manipulations Play Nice Together

One of the pleasant aspects of the repair approach to intervention in aging, such as that proposed in the Strategies for Engineered Negligible Senescence (SENS), is that all distinct forms of repair therapy can reasonably be expected to complement one another. Undergo a procedure to fix mitochondrial damage or break down an AGE such as glucospane, for example, and you are better off. Undergo both therapies and you will gain a commensurately greater benefit.

Unfortunately, this expectation of complementary therapies is very much not the case when it comes to attempts to slow down aging by genetic, epigenetic, or other metabolic manipulation. Metabolism is enormously complex, and even the well-studied phenomenon of calorie restriction isn’t yet fully understood in terms of how the machinery of genes, proteins, and controlling signals all ties together to increase life span and improve health. Varied methods of extending life by slowing aging often turn out to operate on different portions of the same mechanism, or harmful when used together even though they are beneficial on their own.

One thing often tried by research groups that discover a novel way of slowing aging in laboratory animals is to try out the new method in calorie restricted animals: will the effects on life span complement one another and thus lead to a greater extension of life than is the case for either method on its own? Few presently known genetic alterations or other methods of slowing aging produce more than a 30% life extension in mice, and the standing record is 60-70% for growth hormone deficient mice – so at this point in time, it seems unlikely that any new life span record will be set through slowing aging without employing some complementary combination of techniques.

That this hasn’t yet happened suggests that we shouldn’t hold out much hope for the next five to seven years – there has, after all, been a lot of experimentation in mice over the past decade, and especially since the record set using growth hormone deficient mice. Unfortunately purely negative results don’t tend to be published as often as positive results, so it’s not a straightforward matter to find out which combinations of the various known methods to slow aging in mice have been tried only to fail.

Nonetheless, one example showed up recently in work on extending mouse longevity with AC5 knockout (AC5 KO) and calorie restriction, and here is a commentary on that research that clearly makes the point:

Models of longevity (Calorie Restriction and AC5 KO): Result of three bad hypotheses

Third Incorrect Hypothesis: The most widely studied model of longevity is calorie restriction (CR). Our hypothesis was that combining these two models would produce a super longevity model. Accordingly, we placed AC5 KO mice on CR. Within a month we found that all the AC5 KO mice on CR had died. Accordingly, we had to change our hypothesis to include that the AC5 KO and CR models share similar protective and metabolic mechanisms, which could mediate longevity and health, but when superimposed are actually lethal.

This might be taken as a cautionary note on metabolic manipulation as a path to slowing aging: there are pitfalls, it is enormously complicated, and there isn’t much of a roadmap in comparison to the path to repair-based strategies of the sort outlined in the SENS vision.

Source:
http://www.fightaging.org/archives/2012/11/not-all-longevity-manipulations-play-nice-together.php

Source:
http://www.longevitymedicine.tv/not-all-longevity-manipulations-play-nice-together/

Creating Myelin-Producing Cells to Order

Myelin sheaths the axons of nerve cells, but the integrity of this sheathing degrades with age. Transplants of neural stem cells can be used to encourage myelin formation, and researchers are exploring this approach as a therapy for conditions involving more profound myelin loss.

There is always a demand in this sort of research for better and cheaper ways to obtain cells that have the desired effect. It is not trivial, for example, to isolate the right sort of neural stem cell, or establish a protocol for producing these cells from embryonic or induced pluripotent stem cells. A great deal of stem cell research these days involves the discovery of chemical signals, growth environments, and other necessary items to guide the growth of specific cell types.

Here is an example for myelin-forming cells, which will no doubt contribute to the next round of research and development of cell therapies aimed at regrowth of myelin:

Researchers have unlocked the complex cellular mechanics that instruct specific brain cells to continue to divide. This discovery overcomes a significant technical hurdle to potential human stem cell therapies; ensuring that an abundant supply of cells is available to study and ultimately treat people with diseases.

“One of the major factors that will determine the viability of stem cell therapies is access to a safe and reliable supply of cells. This study demonstrates that – in the case of certain populations of brain cells – we now understand the cell biology and the mechanisms necessary to control cell division and generate an almost endless supply of cells.”

The study focuses on cells called glial progenitor cells (GPCs) that are found in the white matter of the human brain. These stem cells give rise to two cells found in the central nervous system: oligodendrocytes, which produce myelin, the fatty tissue that insulates the connections between cells; and astrocytes, cells that are critical to the health and signaling function of oligodendrocytes as well as neurons.

One of the barriers to moving forward with human treatments for myelin disease has been the difficulty of creating a plentiful supply of necessary cells, in this case GPCs. Scientists have been successful at getting these cells to divide and multiply in the lab, but only for limited periods of time, resulting in the generation of limited numbers of usable cells. … Overcoming this problem required that [researchers] master the precise chemical symphony that occurs within stem cells, and which instructs them when to divide and multiply, and when to stop this process and become oligodendrocytes and astrocytes.

Link: http://www.urmc.rochester.edu/news/story/index.cfm?id=3669

Source:
http://www.fightaging.org/archives/2012/11/creating-myelin-producing-cells-to-order.php

Source:
http://www.longevitymedicine.tv/creating-myelin-producing-cells-to-order/

Horizon scanning: Glybera® (alipogene tiparvovec), first gene therapy approved in EU for treatment of patients with lipoprotein lipase deficiency and recurring acute pancreatitis

Source: PharmaLive
Area: News
Glybera® (alipogene tiparvovec), has becomes the first gene therapy approved by the European Commission for the treatment of adult patients diagnosed with familial lipoprotein lipase deficiency (LPLD) and suffering from severe or multiple pancreatitis attacks despite dietary fat restrictions. The diagnosis of LPLD has to be confirmed by genetic testing. The indication is restricted to patients with detectable levels of LPL protein.
 
LPLD is a very rare, inherited disease, caused by mutations in the LPL gene, resulting in highly decreased or absent activity of LPL enzyme in patients. This enzyme is needed in order to break down large fat-carrying particles (chylomicrons) that circulate in the blood after each meal. When such particles accumulate in …Source:
http://www.medworm.com/index.php?rid=6684920&cid=c_449_13_f&fid=38936&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FNews%2F2012—November%2F02%2FHorizon-scanning-Glybera-alipogene-tiparvovec-first-gene-therapy-approved-in-EU-for-treatment-of-patients-with-lipoprotein-lipase-deficiency-and-recurring-acute-pancreatitis%2F

Source:
http://www.longevitymedicine.tv/horizon-scanning-glybera-alipogene-tiparvovec-first-gene-therapy-approved-in-eu-for-treatment-of-patients-with-lipoprotein-lipase-deficiency-and-recurring-acute-pancreatitis/

GEN’s "Cellular Therapy Wave Finally Cresting". An overview and data set.


We first provided a listing (with very few details) of industry-sponsored late-stage (pivotal, phase 3 and 2/3) cell therapy clinical trials on this blog late last year (see the posting here).

We are now pleased to we have worked with Genetic Engineering and Biotechnology News and Enal Razvi of Select Biosciences to provide an updated (as of June 2012) and more detailed listing of industry-sponsored late-stage (pivotal, phase 3 and 2/3) cell therapy clinical trials (excluding cell-based immunotherapies which we intend to cover in a follow-up article).

A link to the listing can be found in an article published today entitled “Cellular Therapy Wave Finally Cresting” found in the November 1, 2012 issue of GEN.  

While not my favorite title, the article is a brief – but we hope useful – overview of the sector and its pipeline.  It also provides a snapshot of the cell therapy products already in commercial distribution. 
Some will quibble about the numbers. Certainly others have published larger revenue numbers, for instance, but in our view these have almost always included revenue from cord blood banking which we have excluded.
We encourage you to read the article but for convenience here is a direct link to the spreadsheet.  Of course it’s already out-dated but we’ll do an update again soon here on this blog.


Hope this is useful.
–Lee


Source:
http://feedproxy.google.com/~r/CellTherapyBlog/~3/ctijFXeY01M/gens-cellular-therapy-wave-finally.html

Source:
http://www.longevitymedicine.tv/gens-cellular-therapy-wave-finally-cresting-an-overview-and-data-set/

Mucuna Formulation No.25818 for Parkinson’s Disease: Pankaj Oudhia’s Medicinal Plant Database – Video

http://www.youtube.com/watch?v=NhL01abvRBs

Mucuna Formulation No.25818 for Parkinson #39;s Disease: Pankaj Oudhia #39;s Medicinal Plant Database
Mucuna pruriens (L.) DC. Formulations for Parkinson #39;s disease from Pankaj Oudhia #39;s Medicinal Plant Database: Septenary Ingredients Important Septenary Ingredients of Mucuna pruriens (Wild Collection) based Traditional Herbal Formulations used for treatment of Parkinson #39;s disease. In Indian Traditional Healing thousands of Mucuna based Traditional Herbal Formulations are used for treatment of Parkinson #39;s disease. Most of these Herbal Formulations are still waiting for documentation. Pankaj Oudhia has collected information about +40000 promising Formulations during his Ethnobotanical surveys during 1990-2012. Present series is a part of the documentation work. – This video is a part of Compilation of Pankaj Oudhia #39;s Research Works at Indira Gandhi Agricultural University, Raipur, India (1990-2001), – This video is a part of Pankaj Oudhia #39;s report on Indo-African Traditional Healing and Forgotten Herbal Formulations. – This video is a part of Pankaj Oudhia #39;s report on Endangered Species of India. – This video is a part of Pankaj Oudhia #39;s report on Forgotten Herbal Formulations of the World with special reference to Asia. – This video is a part of Pankaj Oudhia #39;s report on North American and European Medicinal Species in Traditional Healing of Asia. – This video is a part of Pankaj Oudhia #39;s series on Forgotten Traditional Formulations for Parkinson #39;s disease. – This video is a part of Pankaj Oudhia #39;s report on Mucuna species in Indian Traditional Healing. – This video is a …From:Pankaj OudhiaViews:0 0ratingsTime:00:19More inScience Technology

The rest is here:
Mucuna Formulation No.25818 for Parkinson’s Disease: Pankaj Oudhia’s Medicinal Plant Database – Video

Source:
http://www.longevitymedicine.tv/mucuna-formulation-no-25818-for-parkinsons-disease-pankaj-oudhias-medicinal-plant-database-video/

Mucuna Formulation No.25813 for Parkinson’s Disease: Pankaj Oudhia’s Medicinal Plant Database – Video

http://www.youtube.com/watch?v=w1TF3JCkY4E

Mucuna Formulation No.25813 for Parkinson #39;s Disease: Pankaj Oudhia #39;s Medicinal Plant Database
Mucuna pruriens (L.) DC. Formulations for Parkinson #39;s disease from Pankaj Oudhia #39;s Medicinal Plant Database: Septenary Ingredients Important Septenary Ingredients of Mucuna pruriens (Wild Collection) based Traditional Herbal Formulations used for treatment of Parkinson #39;s disease. In Indian Traditional Healing thousands of Mucuna based Traditional Herbal Formulations are used for treatment of Parkinson #39;s disease. Most of these Herbal Formulations are still waiting for documentation. Pankaj Oudhia has collected information about +40000 promising Formulations during his Ethnobotanical surveys during 1990-2012. Present series is a part of the documentation work. – This video is a part of Compilation of Pankaj Oudhia #39;s Research Works at Indira Gandhi Agricultural University, Raipur, India (1990-2001), – This video is a part of Pankaj Oudhia #39;s report on Indo-African Traditional Healing and Forgotten Herbal Formulations. – This video is a part of Pankaj Oudhia #39;s report on Endangered Species of India. – This video is a part of Pankaj Oudhia #39;s report on Forgotten Herbal Formulations of the World with special reference to Asia. – This video is a part of Pankaj Oudhia #39;s report on North American and European Medicinal Species in Traditional Healing of Asia. – This video is a part of Pankaj Oudhia #39;s series on Forgotten Traditional Formulations for Parkinson #39;s disease. – This video is a part of Pankaj Oudhia #39;s report on Mucuna species in Indian Traditional Healing. – This video is a …From:Pankaj OudhiaViews:0 0ratingsTime:00:14More inScience Technology

Read this article:
Mucuna Formulation No.25813 for Parkinson’s Disease: Pankaj Oudhia’s Medicinal Plant Database – Video

Source:
http://www.longevitymedicine.tv/mucuna-formulation-no-25813-for-parkinsons-disease-pankaj-oudhias-medicinal-plant-database-video/

New Health, Wellness and Fitness Strategies with The Caveman Doctor


New Health, Wellness and Fitness Strategies with The Caveman Doctor John Spencer Ellis
http://www.johnspencerellis.com Dr. John Spencer Ellis is joined by Colin Champ, MD "The Caveman Doctor". JSE and The Caveman Doctor cover important health and fitness topics such as new vs. old philosophies on optimal health and fitness, sleep science, western vs. integrative vs. holistic medicine and much more. You will also learn about medical approaches to cleansing and detoxing, cancer prevention and treatment, and longevity medicine. Your eyes are about to be opened wide!From:John Spencer EllisViews:5 0ratingsTime:39:59More inEducation

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New Health, Wellness and Fitness Strategies with The Caveman Doctor