2013 Alabama Brain Bee – Video

http://www.youtube.com/watch?v=K-YHGQcaLH4

2013 Alabama Brain Bee
UAB will be hosting the 3rd Annual Alabama Brain Bee. The Alabama Brain Bee is a free neuroscience competition available to all high school students within the state. Dr. Myslinski, the founder of the International Brain Bee has the goal of “[motivating] our youth to learn more about the brain… We need their energy and their passion to help find cures for Autism, Parkinson #39;s disease, multiple sclerosis, spinal cord injury and other brain disorders.” All contestants at the 2013 Alabama Brain Bee will receive a free T-Shirt and a certificate of participation. Top 10 contestants will receive a signed copy of a New York Times Bestselling book. The statewide winner of the competition will earn an expenses paid trip for two to the National Competition. For more information about competition rules, preparation resources, and the registration form, visit our website at http://www.tinyurl.com/AlabamaBrainBee. The registration deadline is January 12th, 2013 so register now!From:Alabama Brain BeeViews:68 1ratingsTime:01:22More inScience Technology

Go here to see the original:
2013 Alabama Brain Bee – Video

Source:
http://www.longevitymedicine.tv/2013-alabama-brain-bee-video/

Aniracetam Bulk Powder – Video

http://www.youtube.com/watch?v=JkAChe5pQv8

Aniracetam Bulk Powder
Buy from Amazon UK Site redirect.viglink.com?key=083bca13018b6acb381a415148cefb98 out=http%3A%2F%2Fwww%2Eamazon%2Eco%2Euk%2Fexec%2Fobidos%2FASIN%2FB007P0QBWO%2Fhealth%5Ffab%2D21 Product Description Aniracetam Bulk Powder Aniracetam, first recognized among the nootropics in 1979, was introduced to the marketplace in 1993. Currently, it is sold worldwide under a number of brands. Aniracetam is a nootropic nutritional supplement which has significantly beneficial effects in the areas of cognition and memory. It is also one of the most potent substances in its class, and works without any type of sedative or sedation effects. Cognitive receptors are supported and neurons protected with this supplement. Some of the most well-known benefits of Aniracetam are related to improved cognition and mental functioning. This includes better memory, increased mental energy and improved attention span. There is also some evidence to suggest that this supplement may also help to improve immune function, increase resistance to infection and improve blood flow (both in the brain and throughout the body). Aniracetam may also help to treat a variety of illnesses. Studies have shown some effectiveness on mild to moderate dementia, Alzheimer #39;s and Parkinson #39;s disease, among others. Disclaimer Fabriano Boutique is a participant in the Amazon EU Associates Programme, an affiliate advertising programme designed to provide a means for sites to earn advertising fees by advertising and linking to …From:brock mobleyViews:0 0ratingsTime:00:56More inScience Technology

See the original post:
Aniracetam Bulk Powder – Video

Source:
http://www.longevitymedicine.tv/aniracetam-bulk-powder-video/

ART BELL Predictions for 2006 – Part I – 2005 Classic Show C2CAM – Video

http://www.youtube.com/watch?v=34ue3JnqKlI

ART BELL Predictions for 2006 – Part I – 2005 Classic Show C2CAM
WATCH THE LATEST VIDEO THAT CAME OUT TODAY HERE http://www.youtube.com http://www.jetstreamnews.com http://www.jetnews.us http http://www.youtube.com If You Use Twitter heres the Twitter address or just click the twitter link on the right of the channel page twitter.com Date: 12-30-05 Host: Art Bell Guests: Open Lines Art Bell hosted the first of two shows featuring Predictions for 2006 as made by callers. Art dutifully recorded their forecasts and also reviewed some predictions from last year. Here #39;s what Coast listeners believe will happen in the coming year: A powerful hurricane will hit the United States in August 2006 that will make “Katrina look like a baby throwing a tantrum,” according to David in Arizona. The world will learn that Bono is actually the Anti-Christ; the Son of God will be revealed. An earthquake will separate Southern California (San Diego area) from the rest of the state. North Korea will collapse and China will take over, divined Bill from Oklahoma. A huge explosion will rock Cheyenne Mountain in Colorado; Mount Rainier will explode. Rev. John said World War III will be underway by July 2006. A lost city will be uncovered by a hurricane somewhere in Central America. Canadians will sabotage their US food exports with harmful nanotechnology. Fidel Castro will pass away and Cuba will become the new Las Vegas. President George W. Bush will resign under threat of impeachment. An electro-magnetic disturbance will cause the skies to turn brown; alien spaceships visiting our planet …From:zigdogshowViews:7 0ratingsTime:02:29:31More inEducation

View original post here:
ART BELL Predictions for 2006 – Part I – 2005 Classic Show C2CAM – Video

Source:
http://www.longevitymedicine.tv/art-bell-predictions-for-2006-part-i-2005-classic-show-c2cam-video/

Presentation- Sanofi / Michael J. Fox Foundation for Parkinson’s Research – Video

http://www.youtube.com/watch?v=63Yt2WmDti8

Presentation- Sanofi / Michael J. Fox Foundation for Parkinson #39;s Research
In the spirit of developing new and creative research collaborations to speed up delivery of effective therapies for patients, the Michael J. Fox Foundation for Parkinson #39;s Research (MJFF) and Sanofi are collaborating to explore the potential use of a dormant Sanofi compound, AVE8112, in the treatment of Parkinson #39;s disease. Trial results will be owned by MJFF and shared with Sanofi. This is an excellent example of a novel approach to enhancing our collective ability to tackle complex diseases. Presented by: Marc Bonnefoi, DVM, PhD Head of the North America R D Hub and Vice President of Disposition, Safety and Animal Research Scientific Core Platform, Sanofi Todd Sherer, PhD CEO, Michael J. Fox Foundation for Parkinson #39;s ResearchFrom:FasterCuresViews:12 0ratingsTime:17:08More inNonprofits Activism

Go here to read the rest:
Presentation- Sanofi / Michael J. Fox Foundation for Parkinson’s Research – Video

Source:
http://www.longevitymedicine.tv/presentation-sanofi-michael-j-fox-foundation-for-parkinsons-research-video/

System Vario Plus – Video

http://www.youtube.com/watch?v=GUa5PtmFS08

System Vario Plus
Buy from Amazon UK Site redirect.viglink.com?key=083bca13018b6acb381a415148cefb98 out=http%3A%2F%2Fwww%2Eamazon%2Eco%2Euk%2Fexec%2Fobidos%2FASIN%2FB005NYJDGA%2Fhealth%5Ffab%2D21 Product Description System Vario Plus Particularly suitable for reading over long periods of time and for users who cannot hold magnifiers freely (eg age-related shaking or Parkinson #39;s disease). Magnifier heads with a diametre greater than 58mm are fitted with a retractable red reading line for easier line orientation and increased reading speed. The rectangular magnifier heads are equipped with a supplementary swivel lens for additional magnification. Disclaimer Fabriano Boutique is a participant in the Amazon EU Associates Programme, an affiliate advertising programme designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon UK Site. Amazon and the Amazon logo are trademarks of Amazon, Inc. or its affiliates.From:shayne zamoraViews:0 0ratingsTime:00:58More inScience Technology

More:
System Vario Plus – Video

Source:
http://www.longevitymedicine.tv/system-vario-plus-video/

Parkinsons Deep Brain Stimulation – Video

http://www.youtube.com/watch?v=mO3C6iTpSGo

Parkinsons Deep Brain Stimulation
An individual with a severe tremor from Parkinson #39;s disease demonstrates the effectiveness of Deep Brain Stimulation (DBS). DBS is the implantation of electrodes into the brain along with a pacemaker-like controller and battery which is implanted in the chest. For Parkinson #39;s disease, the electrodes typically target the subthalamic nucleus, an area of the basal ganglia, which is involved in motor selection and even cognitive/emotional control. The settings for the device can be manually adjusted by the patient. This demonstration shows what a dramatic improvement the intervention can have. This video is not my own; thank you very much to the patient and research personnel that contributed it.From:Mike ClaffeyViews:2 0ratingsTime:02:07More inScience Technology

Go here to read the rest:
Parkinsons Deep Brain Stimulation – Video

Source:
http://www.longevitymedicine.tv/parkinsons-deep-brain-stimulation-video/

Parkinson’s Disease with Sharon Puszko PhD, LMT – Bon Vital’ CE Team – Video

http://www.youtube.com/watch?v=8esZGwlE7ME

Parkinson #39;s Disease with Sharon Puszko PhD, LMT – Bon Vital #39; CE Team
bonvital.com A graduate of the University of California with a major in education. After teaching Biology and English internationally, in Europe, Asia, Central America and the Eastern United States, Sharon made a career change into the wellness field in 1986. She attended massage school in Northern California and then graduated from the Pittsburgh School of Massage Therapy and Healthbuilders School of Massage Therapy in St. Augustine, FL. Along with overseeing the function of DAYBREAK Geriatric Massage Institute, she has a private practice and does volunteer hospice work. She travels extensively throughout the US and internationally teaching the DAY-BREAK Geriatric Massage Level 1 and Level 2 workshops in massage schools and community colleges. Member ABMP (associated Bodywork Massage Professionals). Volunteer in St. Vincent #39;s (Indianapolis) Hospice Care Program.From:Bon VitalViews:0 0ratingsTime:01:34More inEducation

Original post:
Parkinson’s Disease with Sharon Puszko PhD, LMT – Bon Vital’ CE Team – Video

Source:
http://www.longevitymedicine.tv/parkinsons-disease-with-sharon-puszko-phd-lmt-bon-vital-ce-team-video/

Royal Jelly 1000mg – Video

http://www.youtube.com/watch?v=7M7WzMpe-KE

Royal Jelly 1000mg
Buy from Amazon CA Site http://www.amazon.ca Product Description Royal Jelly 1000mg This is for 1 bottle of Royal Jelly 1000mg 360s. [[Function: It has been reported as a possible immunomodulatory agent. It has also been reported to stimulate the growth of glial cells and neural stem cells in the brain, which may relate to claims for its use as a longer-term cognitive enhancer and as a beneficial agent in cases of Parkinson #39;s Disease.]] — [[Ingredients: Pure Natural Royal Jelly 1000mg]] — [[Other Ingredients: gelatin, soy lecithin, glycerin and yellow beeswax]] — [[Directions: For adults, take one (1) softgel one to three times daily, preferably with a meal. If you have never taken bee products, start with a small serving per day and increase gradually in order to assess whether you are allergic.]] — [[Store Retail Price: 131.98 per bottle]] Disclaimer: Orchid is a participant in the Amazon.ca, Inc. Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon CA Site. Amazon and the Amazon logo are trademarks of Amazon, Inc. or its affiliates.From:wilmer hoangViews:0 0ratingsTime:00:57More inHowto Style

More:
Royal Jelly 1000mg – Video

Source:
http://www.longevitymedicine.tv/royal-jelly-1000mg-video/

[5 Bottles Royal – Video

http://www.youtube.com/watch?v=JbEwoxm88xg

[5 Bottles Royal
Buy from Amazon CA Site http://www.amazon.ca Product Description [5 Bottles Royal This is for 5 bottles of Royal Jelly 1000mg 360s. [[Function: It has been reported as a possible immunomodulatory agent. It has also been reported to stimulate the growth of glial cells and neural stem cells in the brain, which may relate to claims for its use as a longer-term cognitive enhancer and as a beneficial agent in cases of Parkinson #39;s Disease.]] — [[Ingredients: Pure Natural Royal Jelly 1000mg]] — [[Other Ingredients: gelatin, soy lecithin, glycerin and yellow beeswax]] — [[Directions: For adults, take one (1) softgel one to three times daily, preferably with a meal. If you have never taken bee products, start with a small serving per day and increase gradually in order to assess whether you are allergic.]] — [[Store Retail Price: 131.98 per bottle]] Disclaimer: Orchid is a participant in the Amazon.ca, Inc. Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon CA Site. Amazon and the Amazon logo are trademarks of Amazon, Inc. or its affiliates.From:mohamed boehmViews:0 0ratingsTime:00:57More inHowto Style

Here is the original post:
[5 Bottles Royal - Video

Source:
http://www.longevitymedicine.tv/5-bottles-royal-video/

[25 Bottles Royal – Video

http://www.youtube.com/watch?v=K94yxBhhrrY

[25 Bottles Royal
Buy from Amazon CA Site http://www.amazon.ca Product Description [25 Bottles Royal This is for 25 bottles of Royal Jelly 1000mg 360s. [[Function: It has been reported as a possible immunomodulatory agent. It has also been reported to stimulate the growth of glial cells and neural stem cells in the brain, which may relate to claims for its use as a longer-term cognitive enhancer and as a beneficial agent in cases of Parkinson #39;s Disease.]] — [[Ingredients: Pure Natural Royal Jelly 1000mg]] — [[Other Ingredients: gelatin, soy lecithin, glycerin and yellow beeswax]] — [[Directions: For adults, take one (1) softgel one to three times daily, preferably with a meal. If you have never taken bee products, start with a small serving per day and increase gradually in order to assess whether you are allergic.]] — [[Store Retail Price: 131.98 per bottle]] Disclaimer: Orchid is a participant in the Amazon.ca, Inc. Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon CA Site. Amazon and the Amazon logo are trademarks of Amazon, Inc. or its affiliates.From:jess pettyViews:0 0ratingsTime:00:57More inHowto Style

Read this article:
[25 Bottles Royal - Video

Source:
http://www.longevitymedicine.tv/25-bottles-royal-video/

Calorie Restriction and Core Body Temperature in Humans

Another of the observed effects of calorie restriction in lower animals is shown to exist in humans as well: "Reduction of body temperature has been proposed to contribute to the increased lifespan in calorie restricted animals and mice overexpressing the uncoupling protein-2 in hypocretin neurons. However, nothing is known regarding the long-term effects of calorie restriction (CR) with adequate nutrition on body temperature in humans. In this study, 24-hour core body temperature was measured every minute by using ingested telemetric capsules in 24 men and women consuming a CR diet for an average of 6 years, 24 age- and sex-matched sedentary (WD) and 24 body fat-matched exercise-trained (EX) volunteers, who were eating Western diets. ... Mean 24-hour, day-time and night-time core body temperatures were all significantly lower in the CR group than in the WD and EX groups ... Long-term CR with adequate nutrition in lean and weight-stable healthy humans is associated with a sustained reduction in core body temperature, similar to that found in CR rodents and monkeys. This adaptation is likely due to CR itself, rather than to leanness, and may be involved in slowing the rate of aging."

Link: http://www.impactaging.com/papers/v3/n4/full/100280.html

[2 Bottles Royal – Video

http://www.youtube.com/watch?v=qIuWvHJFI-w

[2 Bottles Royal
Buy from Amazon CA Site http://www.amazon.ca Product Description [2 Bottles Royal This is for 2 bottles of Royal Jelly 1000mg 180s. [[Function: It has been reported as a possible immunomodulatory agent. It has also been reported to stimulate the growth of glial cells and neural stem cells in the brain, which may relate to claims for its use as a longer-term cognitive enhancer and as a beneficial agent in cases of Parkinson #39;s Disease.]] — [[Ingredients: Pure Natural Royal Jelly 1000mg]] — [[Other Ingredients: gelatin, soy lecithin, glycerin and yellow beeswax]] — [[Directions: For adults, take one (1) softgel one to three times daily, preferably with a meal. If you have never taken bee products, start with a small serving per day and increase gradually in order to assess whether you are allergic.]] — [[Store Retail Price: 65.98 per bottle]] Disclaimer: Orchid is a participant in the Amazon.ca, Inc. Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon CA Site. Amazon and the Amazon logo are trademarks of Amazon, Inc. or its affiliates.From:mohamed boehmViews:0 0ratingsTime:00:57More inHowto Style

Visit link:
[2 Bottles Royal - Video

Source:
http://www.longevitymedicine.tv/2-bottles-royal-video/

Increased Longevity in Mice by Removing Cardiotrophin 1

Here is an question to think on while you recover from the excesses of the recent holiday: should we expect there to be, in humans, mice, or other species, many simple genetic alterations that are unambiguously beneficial for the individual, yet which evolution did not select for? Another way of looking at this question: why is it that there exist a range of ways to engineer slightly-genetically-altered mice that are stronger, healthier, and longer-lived than the standard wild variants?

The classical answer to this question suggests that these improvements come with fitness costs in the wild, or – more subtly – have the effect of dramatically reducing ability to survive under some rare combination of environmental circumstances. This is obviously the case when you look at mice lacking growth hormone, which live 60-70% longer than their peers, but are absolutely unfit for life in the wild due to their small size and, more importantly, issues with maintaining body temperature due to that small size. But for unambiguously all-round beneficial mutations like myostatin knockout, one has to think harder about how this could be a disadvantage.

Here is another example of a mutation that everyone would want for their offspring, should it turn out to work much the same way in humans:

Absence of Cardiotrophin 1 Is Associated With Decreased Age-Dependent Arterial Stiffness and Increased Longevity in Mice

Cardiotrophin 1 (CT-1), an interleukin 6 family member, promotes fibrosis and arterial stiffness. We hypothesized that the absence of CT-1 influences arterial fibrosis and stiffness, senescence, and life span. In senescent 29-month-old mice, vascular function was analyzed by echotracking device. Arterial histomorphology, senescence, metabolic, inflammatory, and oxidative stress parameters were measured.

Survival rate of wild-type and CT-1-null mice was studied. … The wall stress-incremental elastic modulus curve of old CT-1-null mice was shifted rightward as compared with wild-type mice, indicating decreased arterial stiffness. Media thickness and wall fibrosis were lower in CT-1-null mice. CT-1-null mice showed decreased levels of inflammatory, apoptotic, and senescence pathways, whereas telomere-linked proteins, DNA repair proteins, and antioxidant enzyme activities were increased. CT-1-null mice displayed a 5-month increased median longevity compared with wild-type mice.

The absence of CT-1 is associated with decreased arterial fibrosis, stiffness, and senescence and increased longevity in mice likely through downregulating apoptotic, senescence, and inflammatory pathways. CT-1 may be a major regulator of arterial stiffness with a major impact on the aging process.

I look forward to the day on which one can take a flight across the Pacific as a medical tourist, drop into a reputable clinic, and have a few genetic alterations done: myostatin, cardiotrophin 1, and others that arise and are shown to have no downsides for people living in a society with access to modern medicine.

Source:
http://www.fightaging.org/archives/2012/11/increased-longevity-in-mice-by-removing-cardiotrophin-1.php

Source:
http://www.longevitymedicine.tv/increased-longevity-in-mice-by-removing-cardiotrophin-1/

[12 Bottles Royal – Video

http://www.youtube.com/watch?v=uK6aRd0kIkI

[12 Bottles Royal
Buy from Amazon CA Site http://www.amazon.ca Product Description [12 Bottles Royal This is for 12 bottles of Royal Jelly 1000mg 360s. [[Function: It has been reported as a possible immunomodulatory agent. It has also been reported to stimulate the growth of glial cells and neural stem cells in the brain, which may relate to claims for its use as a longer-term cognitive enhancer and as a beneficial agent in cases of Parkinson #39;s Disease.]] — [[Ingredients: Pure Natural Royal Jelly 1000mg]] — [[Other Ingredients: gelatin, soy lecithin, glycerin and yellow beeswax]] — [[Directions: For adults, take one (1) softgel one to three times daily, preferably with a meal. If you have never taken bee products, start with a small serving per day and increase gradually in order to assess whether you are allergic.]] — [[Store Retail Price: 131.98 per bottle]] Disclaimer: Orchid is a participant in the Amazon.ca, Inc. Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon CA Site. Amazon and the Amazon logo are trademarks of Amazon, Inc. or its affiliates.From:wilmer hoangViews:0 0ratingsTime:00:58More inHowto Style

Read the original post:
[12 Bottles Royal - Video

Source:
http://www.longevitymedicine.tv/12-bottles-royal-video/

Getting to the heart of presidential fitness: how much do we need to know? – Salon

Differences in health policy weren't the only bones presidential candidates had to pick last week. They also sparred over details of their personal health. And with the next debate and Super Tuesday primaries fast approaching, these skirmishes are likely to escalate.

In the run-up to the Las Vegas Democratic presidential primary face-off, Vermont Sen. Bernie Sanders' national press secretary, Briahna Joy Gray, told CNN that opponents are trying to use his October heart attack against him. Then she mistakenly claimed that Mike Bloomberg "has suffered heart attacks in the past" a statement she quickly walked back after a Bloomberg adviser said in a tweet it was a "Trumpy lie."

He did not have a heart attack, Bloomberg's camp explained, trying to differentiate its candidate's health status. He had stents. The former New York mayor, according to the campaign, had coronary stents inserted two decades ago after a cardiac test indicated they might be useful.

Feathers still ruffled, the two candidates went at it again on the debate stage.

"I think the one area, maybe, that Mayor Bloomberg and I share, you have two stents, as well," Sanders said Thursday to his rival onstage.

Advertisement:

Bloomberg responded, "Twenty-five years ago."

It's not surprising, with the oldest crop ever of presidential candidates, that their vital signs are becoming a talking point.

"When it comes to politics, personal health is just one more issue to try and leverage," said Arthur Caplan, a professor of bioethics at NYU School of Medicine in New York City.

That got us wondering how this information fits into the facts voters weigh. And in evaluating a candidate's long-term health or electability, does it really matter whether a patient got a stent as part of treatment for a heart attack, like Sanders, or for another reason, such as to relieve chest pain or following a cardiac stress test, like Bloomberg?

"In this day and age, with the way technology has advanced and the skill sets of the cardiologists, I would say they are practically the same. We expect good results for both," said Dr. Hadley Wilson, a practicing cardiologist in Charlotte, North Carolina, and a member of the American College of Cardiology's board of trustees.

Stents are almost always used when a person is having a heart attack.

Heart attacks can occur when plaque breaks off inside the blood vessels of the heart, causing a blockage. To open the blocked artery, physicians insert stents, which are small, wire-mesh tubes. Afterward, patients are treated with medications to reduce the risk of subsequent heart attacks.

Back when Bloomberg got his, they were commonly used in nonemergency situations to prop open narrowing arteries, with the thought that might prevent a heart attack, said Dr. Suzanne Steinbaum, a cardiologist in New York and a spokesperson for the American Heart Association.

But, since then, "we learned stents don't prevent a heart attack and that using medication might be equally beneficial," Steinbaum said, adding that the best preventive measures are lifestyle choices, such as eating a good diet, exercising and not smoking. Patients still sometimes get stents to alleviate symptoms, such as chest pain, or for other reasons.

Thursday's debate also highlighted the broader question: Just how much of a candidate's medical history is fair game for public consumption?

Sanders, who faced criticism in October for delays in reporting his condition, said he has since released "the full report of that heart attack" including letters from his primary care doctor and two cardiologists attesting to his overall health and recovery.

But candidate Pete Buttigieg, the former mayor of South Bend, Indiana, said Sanders had not provided enough detail and neither, he said, had the others.

"Under President Obama, the standard was that the president would release full medical records, do a physical and release the readout," he said during the debate. "Now, President Trump lowered that standard. He said just a letter from a doctor is enough. And a lot of folks on this stage are now saying that's enough."

Buttigieg himself has yet to provide a full medical record.

"But I am certainly prepared to get a physical, put out the results," he said during the debate. "I think everybody here should be willing to do the same."

Some observers agree there's no such thing as TMI (too much information) when it comes to POTUS (the president of the United States).

"When the country is hiring someone to have their finger on the nuclear button, the expectation of personal privacy is very, very limited," said David Blumenthal, head of the Commonwealth Fund and co-author of "The Heart of Power: Health and Politics in the Oval Office." "It's hard to imagine something [health-related] that would not be relevant."

That argument, though, doesn't always hold up.

When he ran for president in 2008, the then-70-year-old Sen. John McCain released more than 1,000 pages of his medical records.

By contrast, the campaigning Donald Trump initially released a glowing letter from his personal physician that concluded he would be "the healthiest individual ever elected to the presidency." After criticism that the letter lacked specifics, Trump added information on his height, weight and cholesterol levels and went on to become the oldest president, at age 70, to take office, beating out Ronald Reagan, who was just weeks shy of that milestone on Inauguration Day in 1981.

This year, candidates Bloomberg and Sanders are both 78; former Vice President Joe Biden, 77; and Sen. Elizabeth Warren, 70. Sen. Amy Klobuchar is 59, and Buttigieg is the youngest, at 38.

Anything that might be "relevant to a candidate's ability and competence to govern and their longevity of service" should be disclosed, said Blumenthal, who is also a medical doctor.

Voters could then decide what they thought was important. The information might also affect how voters view the choice of a vice president, especially if the candidate for the highest office had a serious illness or something else that might limit their term, he said.

Specifically which records, though, and how to release them is a complicated issue.

Caplan, at NYU, has long advocated setting up a special independent medical panel to evaluate presidential candidates' health and make their findings public.

"It would be like an executive physical, which is what a lot of companies do before they pick a CEO," he said.

And deciding what to test for would be, in itself, complicated. Without a special panel which, even Caplan admits, would meet political inertia the challenges would be numerous. Even locating all the necessary records would be difficult.

The candidates "may have moved around the country, their doctors may have died, or records may not be available," noted Lawrence Altman, who covered many presidential elections as a reporter for The New York Times and is now a global scholar at the Woodrow Wilson International Center for Scholars.

While there is no specific requirement that candidates release any information at all, what readers and voters want to know varies widely.

"It depends on their interest in the candidate," Altman said. "A lot of people superimpose their political choices or feelings on the medical aspect. They are willing to dismiss something if they really like the candidate or make a big issue about it if they don't like the candidate."

See more here:
Getting to the heart of presidential fitness: how much do we need to know? - Salon

Removing Large and Unnecessary Costs Imposed Upon Medicine

Insofar as politics goes, I’m against it. Both in the sense of a support for market anarchism as a desirable form of society and in the sense that what we see in the political sphere of our increasingly centralized societies today is reprehensible and destructive. There is control for the sake of control, ever-greater burdens imposed on builders of new technology, and progress in medicine is slowed for the personal aggrandizement of bureaucrats and those who line their pockets. When power accumulates to any group in society, and that group stands unopposed by peers, then it inevitably becomes corrupt.

The cartel of modern politics as practiced in countries like the US is the source of large and unnecessary costs put upon progress in medical technology – and this is a big problem for those of us who want to live longer, healthier lives. We stand at the dawn of an age in which aging might be treated as a medical condition, in which therapies could be designed to slow or reverse aging. But medicine and medical research labor beneath heavy regulation: the modern guilds like the AMA that seek to reduce supply; the agencies like the FDA that have few incentives to approve new medicines, yet seek ever-greater authority over all forms of treatment; the regulation and nationalization of medical services and insurance that severs customers from prices, and replaces markets with central planning after the Soviet model.

From a practical standpoint people of my views, being a minority, can do little but think of the vast benefits that might be realized should the present political costs imposed on progress in medicine suddenly evaporate. There are few opportunities to do more than that – we paw at the glass and stare longingly at the products on the other side, as it were. Human societies follow certain paths, and most lead away from individual freedoms of the sort needed for rapid progress in technology. Sad but true.

On this theme, here is an essay that enumerates some of the politically-imposed burdens that greatly slow progress in modern medicine and other applications of life science research, written from a far more forgiving libertarian standpoint than my own:

Political Priorities for Achieving Indefinite Life Extension: A Libertarian Approach

While the achievement of radical human life extension is primarily a scientific and technical challenge, the political environment in which research takes place is extremely influential as to the rate of progress, as well as whether the research could even occur in the first place, and whether consumers could benefit from the fruits of such research in a sufficiently short timeframe. I, as a libertarian, do not see massive government funding of indefinite life extension as the solution – because of the numerous strings attached and the possibility of such funding distorting and even stalling the course of life-extension research by rendering it subject to pressures by anti-longevity special-interest constituencies.

Rather, my proposed solutions focus on liberating the market, competition, and consumer choice to achieve an unprecedented rapidity of progress in life-extension treatments. This is the fastest and most reliable way to ensure that people living today will benefit from these treatments and will not be among the last generations to perish. Here, I describe six major types of libertarian reforms that could greatly accelerate progress toward indefinite human life extension.

We can see a modest fraction of what might be achieved by stripping away regulation, guilds, and central planning by comparing progress in medicine over the past twenty years with progress in computing and software. Consider what computers and their role in everyday life would look like if it had always been the case that introducing a new machine or new software package meant spending years and $100 million to pass a bureaucratic one-size-fits-all process – and where radical new designs required a decade of expensive lobbying to be added to the list of what is permitted.

Yet this is exactly where things stand with medicine, at a time in which it is more important than it has ever been for progress to occur as rapidly as possible. A hundred thousand lives are lost every day to degenerative aging, and we might do something about that in the years ahead – but the therapies will emerge far more slowly than they would in a society that was more free and open than ours.

Source:
http://www.fightaging.org/archives/2012/11/removing-large-and-unnecessary-costs-imposed-upon-medicine.php

Source:
http://www.longevitymedicine.tv/removing-large-and-unnecessary-costs-imposed-upon-medicine/

Improvements in Printed Cartilage Scaffolds

Cartilage is a deceptively complex tissue to build, due to the small-scale structure that determines its mechanical and load-bearing properties – getting that structure right has proven to be a challenge. Researchers have nonetheless been making progress towards this goal in recent years, and the lessons learned will be carried forward to other tissue engineering projects:

The printing of three-dimensional tissue has taken a major step forward with the creation of a novel hybrid printer that simplifies the process of creating implantable cartilage. [The] printer is a combination of two low-cost fabrication techniques: a traditional ink jet printer and an electrospinning machine.

In this study, the hybrid system produced cartilage constructs with increased mechanical stability compared to those created by an ink jet printer using gel material alone. The constructs were also shown to maintain their functional characteristics in the laboratory and a real-life system. The key to this was the use of the electrospinning machine, which uses an electrical current to generate very fine fibres from a polymer solution. Electrospinning allows the composition of polymers to be easily controlled and therefore produces porous structures that encourage cells to integrate into surrounding tissue.

The constructs [were] inserted into mice for two, four and eight weeks to see how they performed in a real life system. After eight weeks of implantation, the constructs appeared to have developed the structures and properties that are typical of elastic cartilage, demonstrating their potential for insertion into a patient.

Link: http://www.sciencedaily.com/releases/2012/11/121121210109.htm

Source:
http://www.fightaging.org/archives/2012/11/improvements-in-printed-cartilage-scaffolds.php

Source:
http://www.longevitymedicine.tv/improvements-in-printed-cartilage-scaffolds/

Vacuole Changes as a Contributing Cause of Yeast Cell Aging

The type of vacuole found in yeast cells is somewhat analogous to the lysosome that we animals possess in that it is involved in breaking down waste products and recycling broken cellular components (via the process of autophagy) that would otherwise harm the cell. It is an agent of cellular housekeeping, in other words. There the similarities end, however, as the vacuole performs many other vital tasks that the more specialized lysosome does not.

So here, researchers show that they can extend life in yeast by reversing a change that occurs in the vacuole. Because the vacuole has many more tasks than the lysosome, it’s not immediately clear that this has any application to our biology of aging, however. It is still worth keeping an eye on this research as we know that decline in lysosomal function (and thus of cellular housekeeping) is important in animal aging. You might recall, for example, that researchers managed to reverse the age-related loss of liver function in mice by finding a way to keep lysosomal function running at youthful rates. Similarly, reversing the root causes of lysosomal decline is on the SENS agenda – to be achieved by breaking down the build up of metabolic waste products that accumulate in lysosomes and cause them to malfunction.

Normally, mitochondria [in yeast] are beautiful, long tubes, but as cells get older, the mitochondria become fragmented and chunky. The changes in shape seen in aging yeast cells are also observed in certain human cells, such as neurons and pancreatic cells, and those changes have been associated with a number of age-related diseases in humans.

The vacuole – and its counterpart in humans and other organisms, the lysosome – has two main jobs: degrading proteins and storing molecular building blocks for the cell. To perform those jobs, the interior of the vacuole must be highly acidic. [Researchers] found that the vacuole becomes less acidic relatively early in the yeast cell’s lifespan and, critically, that the drop in acidity hinders the vacuole’s ability to store certain nutrients. This, in turn, disrupts the mitochondria’s energy source, causing them to break down. Conversely, when [researchers] prevented the drop in vacuolar acidity, the mitochondria’s function and shape were preserved and the yeast cells lived longer.

Until now, the vacuole’s role in breaking down proteins was thought to be of primary importance. We were surprised to learn it was the storage function, not protein degradation, that appears to cause mitochondrial dysfunction in aging yeast cells. … The unexpected discovery prompted [the researchers] to investigate the effects of calorie restriction, which is known to extend the lifespan of yeast, worms, flies and mammals, on vacuolar acidity. They found that calorie restriction – that is, limiting the raw material cells need – delays aging at least in part by boosting the acidity of the vacuole.

Link: http://www.newswise.com/articles/researchers-define-key-events-early-in-the-process-of-cellular-aging

Source:
http://www.fightaging.org/archives/2012/11/vacuole-changes-as-a-contributing-cause-of-yeast-cell-aging.php

Source:
http://www.longevitymedicine.tv/vacuole-changes-as-a-contributing-cause-of-yeast-cell-aging/

T-cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing

We describe here a novel vector (CD8-LV) derived from lentivirus, which delivers genes exclusively and specifically to CD8+ cells. CD8-LV mediated stable in vitro and in vivo reporter gene transfer as well as efficient transfer of genes encoding TCRs recognizing the melanoma antigen tyrosinase. Strikingly, T cells genetically modified with CD8-LV killed melanoma cells reproducibly more efficiently than CD8+ cells transduced with a conventional lentiviral vector. Neither TCR expression levels, nor the rate of activation-induced death of transduced cells differed between both vector types. Instead, CD8-LV transduced cells showed increased granzyme B and perforin levels as well as an up-regulation of CD8 surface expression in a small subpopulation of cells. Thus, a possible mechanism for CD8-…Source:
http://www.medworm.com/index.php?rid=6763105&cid=c_449_19_f&fid=29474&url=http%3A%2F%2Fbloodjournal.hematologylibrary.org%2Fcgi%2Fcontent%2Fshort%2F120%2F22%2F4334%3Frss%3D1

Source:
http://www.longevitymedicine.tv/t-cell-receptor-gene-transfer-exclusively-to-human-cd8-cells-enhances-tumor-cell-killing/

Towards an Understanding of Why Dopamine Neurons Are Vulnerable in Parkinson’s Disease

The most visible signs of Parkinson’s disease are caused by the progressive destruction of a comparatively small population of dopamine-generating neurons in the brain. But why these cells? A full answer to that question might lead to ways to block progression of the condition:

Neuroinflammation and its mediators have recently been proposed to contribute to neuronal loss in Parkinson’s, but how these factors could preferentially damage dopaminergic neurons has remained unclear until now. [Researchers] were looking for biological pathways that could connect the immune system’s inflammatory response to the damage seen in dopaminergic neurons. After searching human genomics databases, the team’s attention was caught by a gene encoding a protein known as interleukin-13 receptor alpha 1 chain (IL-13Ra1), as it is located in the PARK12 locus, which has been linked to Parkinson’s.

IL-13r?1 is a receptor chain mediating the action of interleukin 13 (IL-13) and interleukin 4 (IL-4), two cytokines investigated for their role as mediators of allergic reactions and for their anti-inflammatory action. With further study, the researchers made the startling discovery that in the mouse brain, IL-13Ra1 is found only on the surface of dopaminergic neurons. “This was a ‘Wow!’ moment.”

The scientists set up long-term experiments using a mouse model in which chronic peripheral inflammation causes both neuroinflammation and loss of dopaminergic neurons similar to that seen in Parkinson’s disease. The team looked at mice having or lacking IL-13Ra1 and then compared the number of dopaminergic neurons in the brain region of interest. The researchers expected that knocking out the IL-13 receptor would increase inflammation and cause neuronal loss to get even worse. Instead, neurons got better.

If further research confirms the IL-13 receptor acts in a similar way in human dopaminergic neurons as in mice, the discovery could pave the way to addressing the underlying cause of Parkinson’s disease. Researchers might, for instance, find that drugs that block IL-13 receptors are useful in preventing loss of dopaminergic cells during neuroinflammation.

Link: http://www.scripps.edu/news/press/2012/20121119conti.html

Source:
http://www.fightaging.org/archives/2012/11/towards-an-understanding-of-why-dopamine-neurons-are-vulnerable-in-parkinsons-disease.php

Source:
http://www.longevitymedicine.tv/towards-an-understanding-of-why-dopamine-neurons-are-vulnerable-in-parkinsons-disease/