Testosterone Replacement Therapy Market Size, Analysis, and Forecast Report 2019-2025 – StartupNG

The report is an all-inclusive research study of the global Testosterone Replacement Therapy market taking into account the growth factors, recent trends, developments, opportunities, and competitive landscape. The market analysts and researchers have done extensive analysis of the global Testosterone Replacement Therapy market with the help of research methodologies such as PESTLE and Porters Five Forces analysis. They have provided accurate and reliable market data and useful recommendations with an aim to help the players gain an insight into the overall present and future market scenario. The Testosterone Replacement Therapy report comprises in-depth study of the potential segments including product type, application, and end user and their contribution to the overall market size.

The Testosterone Replacement Therapy Market carries out financial changes that occur year by years in market, with information about upcoming opportunities and risk to keeps you ahead of competitors. The report also describes top company profiles that present in market with trends worldwide. This research guided you for extending business.

The Testosterone Replacement Therapy Market research report presents a comprehensive assessment of the market and contains thoughtful insights, facts, historical data and statistically-supported and industry-validated market data and projections with a suitable set of assumptions and methodology. It provides analysis and information by categories such as market segments, regions, and product type and distribution channels.

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Segment by Type, the Testosterone Replacement Therapy market is segmented intoGelsInjectionsPatchesOther

Segment by Application, the Testosterone Replacement Therapy market is segmented intoHospitalsClinicsOthers

Regional and Country-level Analysis:North AmericaUnited StatesCanadaAsia-PacificChinaJapanSouth KoreaIndiaSoutheast AsiaAustraliaRest of Asia-PacificEuropeGermanyFranceU.K.ItalyRussiaNordic CountriesRest of EuropeLatin AmericaMexicoBrazilRest of Latin AmericaMiddle East & AfricaTurkeySaudi ArabiaUAERest of MEA

Competitive Landscape and Testosterone Replacement Therapy Market Share AnalysisTestosterone Replacement Therapy market competitive landscape provides details and data information by companies. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on sale and revenue by players for the period 2015-2020. Details included are company description, major business, Testosterone Replacement Therapy product introduction, recent developments, Testosterone Replacement Therapy sales by region, type, application and by sales channel.

The major companies include:AbbVieEndo InternationalEli lillyPfizerActavis (Allergan)BayerNovartisTevaMylanUpsher-SmithFerring PharmaceuticalsKyowa KirinAcerus Pharmaceuticals

A proper understanding of the Testosterone Replacement Therapy Market dynamics and their inter-relations helps in gauging the performance of the industry. The growth and revenue patterns can be revised and new strategic decisions taken by companies to avoid obstacles and roadblocks. It could also help in changing the patterns using which the market will generate revenues. The analysis includes an assessment of the production chain, supply chain, end user preferences, associated industries, proper availability of resources, and other indexes to help boost revenues.

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Market Segmentation based On Type, Application and Region:

The global Testosterone Replacement Therapy is analyzed for different segments to arrive at an insightful analysis. Such segmentation has been done based on type, application and Region.

Global Testosterone Replacement Therapy market is presented to the readers as a holistic snapshot of the competitive landscape within the given forecast period. It presents a comparative detailed analysis of the all regional and player segments, offering readers a better knowledge of where areas in which they can place their existing resources and gauging the priority of a particular region in order to boost their standing in the global market.

The Global Testosterone Replacement Therapy Market is gaining pace and businesses have started understanding the benefits of analytics in the present day highly dynamic business environment. The market has witnessed several important developments over the past few years, with mounting volumes of business data and the shift from traditional data analysis platforms to self-service business analytics being some of the most prominent ones.

For the future period, sound forecasts on market value and volume are offered for each type and application. In the same period, the report also provides a detailed analysis of market value and consumption for each region. These insights are helpful in devising strategies for the future and take necessary steps. New project investment feasibility analysis and SWOT analysis are offered along with insights on industry barriers. Research findings and conclusions are mentioned at the end.

Reasons for Buying This Report:

It Provides A Forward-Looking Perspective on Different Factors Driving or Restraining Market Growth.

It Provides A Five-Year Forecast Assessed on The Basis of How the Market Is Predicted to Grow

It Helps in Understanding the Key Product Segments and Their Future.

It Provides Pin Point Analysis of Changing Competition Dynamics and Keeps You Ahead of Competitors.

It Helps in Making Informed Business Decisions by Having Complete Insights of Market and By Making an In-Depth Analysis of Market Segments.

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Testosterone Replacement Therapy Market Size, Analysis, and Forecast Report 2019-2025 - StartupNG

Testosterone Replacement Therapy Market Industry: By Type, Application, Regional outlook, Manufactures & Forecast to 2029 – The News Brok

Testosterone Replacement Therapy Market contain SWOT analysis of ramp up growth of industry in supply chain, demand, sales with overall portfolio management along with geographical condition. It also have an investigation on manufactures with vary in trends of market along with future scope by 2020-2029

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This report provides detailed historical analysis of global market for Testosterone Replacement Therapy from 2014-2019, and provides extensive market forecasts from 2020-2029 by region/country and subsectors. It covers the sales volume, price, revenue, gross margin, historical growth and future perspectives in the Testosterone Replacement Therapy market.

Development policies and plans are discussed as well as manufacturing processes and cost structures. This report also states import/export, supply and consumption figures as well as cost, price, revenue and gross margin by regions North America, Europe, Japan, China, and other regions (India, Southeast Asia, Central & South America, and Middle East & Africa) and other regions can be added.

This report analyses the impact of COVID-19 on this industry. COVID-19 can affect the global market in 3 ways: by directly affecting production and demand, by creating supply chain and market disruption, and by its financial impact on enterprises and financial markets.

Key Companies Analyzed in this Report are:

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Global Testosterone Replacement Therapy report has been compiled through extensive primary research (through analytical research, market survey and observations) and secondary research. The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industrys value chain.

The Report Segments for Testosterone Replacement Therapy Market Analysis & Forecast 20202029 are as:

Market segment by Type, the product can be split into

Gels

Injections

Patches

Other

Market segment by Application, split into

Hospitals

Clinics

Others

Market split by Sales Channel, can be divided into:

Direct Channel

Distribution Channel

Market segment by Regions/Countries, this report covers

North America (United States, Canada and Mexico)

Europe (Germany, UK, France, Italy, Russia and Spain etc.)

Asia-Pacific (China, Japan, Korea, India, Australia and Southeast Asia etc.)

South America Brazil, Argentina, Colombia and Chile etc.)

Middle East & Africa (South Africa, Egypt, Nigeria and Saudi Arabia etc.)

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If you have any special requirement, please let us know and we can provide you the report as your requirement.

Reasons to get this report:

In an insight outlook, this research report has dedicated to several quantities of analysis industry research (global industry trends) and Testosterone Replacement Therapy market share analysis of high players, along with company profiles, and which collectively include about the fundamental opinions regarding the market landscape, emerging and high-growth sections of Testosterone Replacement Therapy market, high-growth regions, and market drivers, restraints, and also market chances.

The analysis covers Testosterone Replacement Therapy market and its advancements across different industry verticals as well as regions. It targets estimating the current market size and growth potential of the global Testosterone Replacement Therapy Market across sections such as also application and representatives.

Additionally, the analysis also has a comprehensive review of the crucial players on the Testosterone Replacement Therapy market together side their company profiles, SWOT analysis, latest advancements, and business plans.

Major Points Covered in Table of Contents:

Chapter 1 Testosterone Replacement Therapy Market Overview

Chapter 2 Testosterone Replacement Therapy Market Segment Analysis by Player

Chapter 3 Testosterone Replacement Therapy Market Segment Analysis by Type

Chapter 4 Testosterone Replacement Therapy Market Segment Analysis by Application

Chapter 5 Testosterone Replacement Therapy Market Segment Analysis by Sales Channel

Chapter 6 Testosterone Replacement Therapy Market Segment Analysis by Region

Chapter 7 Profile of Leading Testosterone Replacement Therapy Players

Chapter 8 Upstream and Downstream Analysis of Testosterone Replacement Therapy

Chapter 9 Development Trend of Testosterone Replacement Therapy (2020-2029)

Chapter 10 Appendix

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Testosterone Replacement Therapy Market Industry: By Type, Application, Regional outlook, Manufactures & Forecast to 2029 - The News Brok

Nanotechnology In Medical Applications Market To Eyewitness Massive Growth Trends Market Research 2017 to 2022 – Scientect

Theglobal nanomedical marketwas valued at $134.4 billion in 2016. This market is projected to grow at a compound annual growth rate (CAGR) of 14.0% from 2017-2022, and should reach $293.1 billion by 2022 from $151.9 billion in 2017.

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Report Scope:

This report discusses the implications of technology and commercial trends in the context of the current size and growth of the pharmaceutical market, both in global terms and analyzed by the most important national markets. The important technologies supporting nanomedicine are reviewed, and the nature and structure of the nanomedicine industry are discussed with profiles of the leading 60+ companies, including recent merger and acquisition (M&A) activity. Five-year sales forecasts are provided for the national markets including the major therapeutic categories of products involved. Specific product categories quantified include diagnostics, cancer, CNS, anti-infective agents, cardiovasculars and anti-inflammatories.

Report Includes:

An overview of the global markets for nanotechnology used in medical applications Analyses of global market trends, with data from 2016, estimates for 2017, and projections of compound annual growth rates (CAGRs) through 2022 A review of technologies involved, in-depth analysis of applications in practice, and evaluation of future or potential applications Information on many significant products in which the nano dimension has made a significant contribution to product effectiveness A look at the regulatory environment, healthcare policies, demographics, and other factors that directly affect nanotechnology used in medicine Analysis of the markets dynamics, specifically growth drivers, inhibitors, and opportunities Coverage of strategies employed by companies specializing in nanomedicine to meet the challenges of this highly competitive market

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Summary

Nano-enabled medical products began appearing on the market over a decade ago, and some have become best-sellers in their therapeutic categories. The principal areas in which nanomedical products have made an impact are cancer, CNS diseases, cardiovascular disease and infection control. The Summary Table gives estimates of the historical and current markets for these nanomedicine areas with a forecast through 2022.

The U.S. market is by far the largest in the global nanomedicine market and is set to continue to dominate the world marketplace; however, other national markets are expected to increase their shares over the next five years.

Reasons for Doing the Study

Nanomedicine is already an established market. Unlike some other potential applications of nanotechnology, which are still largely experimental, nanomedicine has already produced some significant products in which the nano dimension has made a significant contribution to product effectiveness. Now that aspects of the nanomedicine market are established, it is appropriate to review the technology, see its practical applications so far, evaluate the participating companies and look to its future.

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Nanotechnology In Medical Applications Market To Eyewitness Massive Growth Trends Market Research 2017 to 2022 - Scientect

Nanomedicine Market: Industry Analysis and forecast 2026: By Modality, Diseases, Application and Region – Good Night, Good Hockey

Nanomedicine Marketwas valued US$ XX Bn in 2018 and is expected to reach US$ XX Bn by 2026, at CAGR of XX% during forecast period of 2019 to 2026.

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Nanomedicine is an application of nanotechnology, which are used in diagnosis, treatment, monitoring, and control of biological systems. Nanomedicine usages nanoscale manipulation of materials to improve medicine delivery. Therefore, nanomedicine has facilitated the treatment against various diseases. The nanomedicine market includes products that are nanoformulations of the existing drugs and new drugs or are nanobiomaterials. The research and development of new devices as well as the diagnostics will become, more effective, enabling faster response and the ability to treat new diseases are likely to boost the market growth.

The nanomedicine markets are driven by factors such as developing new technologies for drug delivery, increase acceptance of nanomedicine across varied applications, rise in government support and funding, the growing need for therapies that have fewer side effects and cost-effective. However, long approval process and risks associated with nanomedicine (environmental impacts) are hampering the market growth at the global level. An increase in the out-licensing of nanodrugs and growth of healthcare facilities in emerging economies are likely to create lucrative opportunities in the nanomedicine market.

The report study has analyzed revenue impact of covid-19 pandemic on the sales revenue of market leaders, market followers and disrupters in the report and same is reflected in our analysis.

Nanomedicine Market Segmentation Analysis:Based on the application, the nanomedicine market has been segmented into cardiovascular, neurology, anti-infective, anti-inflammatory, and oncology. The oncology segment held the dominant market share in 2018 and is projected to maintain its leading position throughout the forecast period owing to the rising availability of patient information and technological advancements. However, the cardiovascular and neurology segment is projected to grow at the highest CAGR of XX% during the forecast period due to presence of opportunities such as demand for specific therapeutic nanovectors, nanostructured stents, and implants for tissue regeneration.

Nanomedicine Market Regional Analysis:Geographically, the Nanomedicine market has been segmented into North America, the Europe, Asia Pacific, Latin America, and Middle East & Africa. North America held the largest share of the Nanomedicine market in 2018 due to the rising presence of patented nanomedicine products, the availability of advanced healthcare infrastructure and the rapid acceptance of nanomedicine. The market in Asia Pacific is expected to expand at a high CAGR of XX% during the forecast period thanks to rise in number of research grants and increase in demand for prophylaxis of life-threatening diseases. Moreover, the rising investments in research and development activities for the introduction of advanced therapies and drugs are predicted to accelerate the growth of this region in the near future.

Nanomedicine Market Competitive landscapeMajor Key players operating in this market are Abbott Laboratories, CombiMatrix Corporation, General Electric Company, Sigma-Tau Pharmaceuticals, Inc, and Johnson & Johnson. Manufacturers in the nanomedicine are focusing on competitive pricing as the strategy to capture significant market share. Moreover, strategic mergers and acquisitions and technological innovations are also the key focus areas of the manufacturers.

The objective of the report is to present a comprehensive analysis of Nanomedicine Market including all the stakeholders of the industry. The past and current status of the industry with forecasted market size and trends are presented in the report with the analysis of complicated data in simple language. The report covers all aspects of the industry with a dedicated study of key players that includes market leaders, followers and new entrants by region. PORTER, SVOR, PESTEL analysis with the potential impact of micro-economic factors by region on the market are presented in the report. External as well as internal factors that are supposed to affect the business positively or negatively have been analyzed, which will give a clear futuristic view of the industry to the decision-makers. The report also helps in understanding Nanomedicine Market dynamics, structure by analyzing the market segments and project the Nanomedicine Market size. Clear representation of competitive analysis of key players By Type, Price, Financial position, Product portfolio, Growth strategies, and regional presence in the Nanomedicine Market make the report investors guide.Scope of the Nanomedicine Market:

Nanomedicine Market by Modality:

Diagnostics TreatmentsNanomedicine Market by Diseases:

Oncological Diseases Infectious Diseases Cardiovascular Diseases Orthopedic Disorders Neurological Diseases Urological Diseases Ophthalmological Diseases Immunological DiseasesNanomedicine Market by Application:

Neurology Cardiovascular Anti-Inflammatory Anti-Infectives OncologyNanomedicine Market by Region:

Asia Pacific North America Europe Latin America Middle East AfricaNanomedicine Market Major Players:

Abbott Laboratories CombiMatrix Corporation General Electric Company Sigma-Tau Pharmaceuticals, Inc Johnson & Johnson Mallinckrodt plc. Merck & Company, Inc. Nanosphere, Inc. Pfizer, Inc. Teva Pharmaceutical Industries Ltd. Celgene Corporation UCB (Union Chimique Belge) S.A. AMAG Pharmaceuticals Nanospectra Biosciences, Inc. Arrowhead Pharmaceuticals, Inc. Leadiant Biosciences, Inc. Epeius Biotechnologies Corporation Cytimmune Sciences, Inc.

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Nanomedicine Market: Industry Analysis and forecast 2026: By Modality, Diseases, Application and Region - Good Night, Good Hockey

The 9th ISS R&D Conference Is Opening This Week, but This Year’s Setup Is Different – Science Times

The ninth annual International Space Station Research and Development Conference (ISSRDC) is set to open on Thursday, August 27, at 10 a.m. EDT, coinciding with the microgravity laboratory's 20th anniversary of continuous human presence in space.

NASA Administrator Jim Bridenstine will be opening this year's conference, with the theme "From Vision to Discovery," emphasizing how the past can help guide the future. The ISSRDC is going virtual this year, with the events spread over three nonconsecutive daysbut all falling on Thursdaysstarting this August 27, followed by a session on September 17, and the last being on October 22.

RELATED: Jeanette Epps Set to Be the First Black Woman to Join ISS Crew

According to NASA, the event is the only conference that explores in detail the full breadth of research and development currently underway on the orbiting laboratory, including future research to span the life of the ISS.

On the first Thursday of the ISSRDC, the session will focus on the space administration's commercialization initiative and updates from its leadership. The opening plenary session is also set to include a discussion regarding the evolution of the ISS US National Laboratory. Among the speakers set to appear on the August 27 session are Kathy Lueders, NASA's Human Exploration and Operations Mission Directorate Associate Administrator, and Dr. Thomas Zurbuchen, NASA Science Mission Directorate Associate Administrator.

The September 17 session will tackle business trends that affect the space station. Professor Alessandro Grattoni from the Houston Methodist Research Institute Department of Nanomedicine and Professor Aleksandar Ostrogorsky from the Illinois Institute of Technology's Mechanical and Materials Engineering Department will discuss how the ISS moves closer towards commercial applications.

For the third plenary day of the ISSRDC, NASA's press release announces that it will "touch on a myriad of science and educational activities." The session will focus on 20 years of student investigations enabled by the international space station. Keynote speakers for the third day include Mayo Clinic Director of Transfusion Medicine and Stem Cell Therapy Abba Zubair, New York Stem Cell Foundation Senior Research Investigator Valentina Fossati, Quest Institute's Danny Kim, and Genes in Space Lead Katy Martin.

The full schedule, including the list of speakers and moderators, can be found on the ISS Conference website.

The ISS is a modular space station and a habitable artificial satellite hovering in the Earth's orbit first launched on November 20, 1998. It started as a collaborative effort between the space agencies of five nations: United States (NASA), Russia (Roscosmos), Europe (ESA), Japan (JAXA), and Canada (CSA).

(Photo: Nasa/Getty Images)he International Space Station (ISS) is Backdropped Against The Blue And White Horizon Scene Of Earth And The Blackness Of Space Following Separation From Discovery June 3, 1999.

Since it was launched into space, the ISS has become a space environment and a microgravity research platform for different countriesconducting studies in various fields including astrobiology, meteorology, physics, chemistry, and more. This coming November, according to NASA, its international and commercial partners will be celebrating the 20th year of having humans continuously live and work at the ISS.

RELATED: SpaceX, NASA On the Lookout Before Endeavor Splashdown

Since 2000, it has already accommodated 240 people from 19 countries, across almost 400 flights. Among the achievements by the space environment and microgravity lab include hosting more than 3,000 research inquiries designed by researchers from more than 100 countries.

Check out more news and information on Space and otherNASA Missionson Science Times.

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The 9th ISS R&D Conference Is Opening This Week, but This Year's Setup Is Different - Science Times

Elon Musk may announce human trials at the Neuralink demo. Heres why thats awesome – The Next Web

Im reticent to use the phrase iPhone moment for brain surgery in the first sentence here, but Elon Musk and the team at Neuralink are set to demonstrate the progress made by the company over the past year this Friday and Im excited.

First, its been rumored the company will announce human trials are set to begin this year at the event and thats a pretty big deal. Ill get to why in a moment.

And second: Musks confirmed the event will feature a live demonstration of neurons firing. This is what Im referring to when I talk about an iPhone moment for brain surgery.

Neuralink was founded with a single purpose, one Musk recently reiterated in an interview with Axios: The long term aspiration for Neuralink would be to achieve symbiosis with artificial intelligence.

The big idea here is that Neuralink is building a brain computer interface (BCI), a robot to surgically install it, and all the necessary components to facilitate direct communication between computers and our brains.

Neuralinks BCI is invasive, it has to be implanted in the skull so that tiny wires can be directly inserted into the brain. Per a research paper published by the company last year:

We have built arrays of small and flexible electrode threads, with as many as 3,072 electrodes per array distributed across 96 threads. We have also built a neurosurgical robot capable of inserting six threads (192 electrodes) per minute.

Each thread can be individually inserted into the brain with micron precision for avoidance of surface vasculature and targeting specific brain regions. The electrode array is packaged into a small implantable device that contains custom chips for low-power on-board amplification and digitization: the package for 3,072 channels occupies less than (23 18.5 2) mm3.

A single USB-C cable provides full-bandwidth data streaming from the device, recording from all channels simultaneously.

You read that right: Neuralink is literally going to put a USB-C cord in or on your head. Dont get too excited at the prospect of using a fast charger to get a full nights sleep in just 30 minutes though, because thats not the kind of connectivity were looking at. While details arent clear yet, its assumed the USB-C cable connects the internal device to an external wearable that sends and receives outside signals. However, when it comes to a Musk-inspired gadget. who knows? His cars have external speakers that play fart sounds and snake jazz.

What we do know is that Musks pushing the device through regulatory bodies as a medical device patterned after other similar BCIs. These are typically used to deliver intracranial stimulation or other brain-modulating medical treatments.

Neuralinks plans involve similar capabilities. Musks stated that the device will be able to solve many brain, nervous system, and mental conditions. Hes claimed itll successfully treat everything from strokes to Alztheimers and even made dubious claims that it could eliminate autistic spectrum disorder.

[Read:Elon Musk says Neuralink can solve autism with a brain chip. We call BS]

Musks known for making grandiose claims and then failing to deliver (remember when he invented the tunnel and called it the future of transportation? Or when he said thered be a million self-driving taxis on the road by the end of 2020?). But this is different. At least I hope it is, because Neuralink could be a big damn deal for humanity if hes been playing straight with us.

Neuralink represents the first bold steps towards transhumanism for our species. If you want to really dumb it down, think about BCIs like the computers manufacturers started installing in cars in the 1990s. There was a time, long ago, when youd take your car to a mechanic and theyd diagnose itlike a human doctor making a house call. They listen to it, maybe drive it around the block, and eventually start taking things apart to see if they could confirm their suspected diagnosis.

With computers, myriad mechanical and electrical automobile problems can be diagnosed by simply connecting the car to a workstation. A BCI could offer humans similar sensing capabilities. Imagine if you could diagnose health conditions that require anecdotal evidence such as headaches and other neurologically-induced pain through direct, real-time analsysis of brain activity. Thatd be a game-changer for anyone whos ever had a migraine.

All thats interesting, but none of it is new. Scientists have toiled to create a suitable BCI for medical purposes for decades. The reason Neuralinks event is, potentially, so exciting is that it represents the first time a serious organization has attempted to bring an invasive BCI out of the realm of medicine and into the general consumer sector.

Make no mistake, Musks vision for Neuralink clearly states this device is aimed at everyone. The obvious non-medical benefits would include things like unlocking and opening doors with your mind or sending and receiving text messages as thoughts. These might seem like far-future tech, but the truth is that the ability to do these things has been around awhile. Neuralinks working on the hard parts: designing scalable software andhardware and making the surgery to implant it as much like a clockwork outpatient procedure as possible.

The real benefits, the exciting stuff, has more to do with data gathering than telepathy. A BCI capable of translating brain activity in real-time with enough bandwidth to constantly stream could theoretically make mental health conditions as easily-diagnosed and treatable as physical injuries. Imagine if the mental health equivalent of a sprained wrist say, a mildly traumatic experience could be diagnosed with precision and treated in such a way that progress and improvement could be codified and monitored.

At any rate, the skys the limit. A functioning BCI may or may not bridge the gap between us and whatever fictional supercomputers Musk and the other harbingers of AI-doom think are going to makehumans their pets. But it sure would be nice to have as clear an image of our own brains as we do a 2002 Ford Taurus. If anyone can convince the powers that be, and the general population, that a BCI is a good idea its Elon Musk.

The idea of true human-AI symbiosis seems spooky but heres the tech take: Youre already a human-AI hybrid. You use apps for everything. Computers tell you when to wake up, what email to read, how to spell difficult words, and which lane you should be in on the interstate. You accept all of this direction most of which is controlled by machine learning algorithms because its easier than doing everything the hard way.

Now imagine controlling everything in your home and office with your mind while you bask in the glow of your newfound healthy mental state. We can all worry about the privacy and horror-scenario implications another day right?

Were unclear exactly what time on Friday or on what platform the event will take place, but in the meantime stay tuned to @neuralink and @elonmusk on Twitter.

Published August 24, 2020 18:52 UTC

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Elon Musk may announce human trials at the Neuralink demo. Heres why thats awesome - The Next Web

#UGM2020 goes virtual, promotes wellness and healthy living in the community – The Guam Daily Post

Guam Sports Events Inc. and United Airlines have announced that Guams premier running event is going virtual and the event will be converted into a weeklong virtual race event. Lace up your shoes and get ready to run Guams premier running event, the United Airlines Guam Marathon, beginning Saturday, Sept. 5, through Sunday, Sept 13.

The #UGM2020 is a virtual event/race that can be run or walked from any location, locally and internationally. Registered runners can run, jog or walk at their convenience on a trail, on a treadmill, at the beach or on a track anywhere they can safely complete their race distances of 5K, 10K, Half Marathon, and Full Marathon.

Runners will be responsible for tracking and timing their selected races at any time.

Safety tips for runners

Dont wear a mask or face covering that prevents you from breathing. You need oxygen to run. If you find yourself on a crowded route, you should protect yourself and those around you by spreading out to maintain a distance of at least six feet from other runners and avoiding unnecessary touching.

Run only when it is safe to do so. If local regulations allow you to run outside, be sure to bring a mask or a mouth/nose covering to utilize before and after your run.

Running with a training partner or small group of two to three that you trust is likely safe, depending on the area you live in and the precautions you all take. Before meeting up with others for a run, assess key risk factors such as the level of community spread in your area, if youve been exposed to coronavirus and could be at risk for asymptomatically spreading it, and what your training partners have been doing to stay safe. Remember, when in doubt, it is best to stay safe and postpone your run for another time.

Always wash your hands before and after a run. After completing your run, be sure to change your clothing as soon as possible. Best practice is to pack a change of clothes along with a bag in which to place your used running gear.

Don't run if you're sick. If you're at risk of potentially spreading the virus, stay home. You could potentially expose someone who is at high risk, such as elderly and immunocompromised people, or even someone who is completely healthy. The coronavirus doesn't discriminate.

Be sure to follow UGM social media pages for safety tips.

Register by Aug. 24

Those registered participants who complete their race will be able to receive free event items such as race bib, event T-shirt, towel, beach mat and more. The event also welcomes new registrants to participate at a special rate for $30 at unitedguammarathon.com/register.

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#UGM2020 goes virtual, promotes wellness and healthy living in the community - The Guam Daily Post

Body coach Joe Wicks: Family finances impact on healthy living – Yorkshire Post

NewsPeopleAs the Body Coach Joe Wicks speaks out about the cost of buying expensive healthy foods, Liz Connor hears some top tips for eating well on a tight budget.

Tuesday, 18th August 2020, 11:45 am

From organic produce to fancy superfood supplements, leading a healthy lifestyle can seem intimidatingly expensive and time-consuming to many of us especially if you follow certain food bloggers on social media.

Its something that personal trainer Joe Wicks has spoken out about. The Body Coach, who says he was born into a working-class family, said its more convenient to live a healthy lifestyle in some parts of the country than others, because of the types of food on offer.

I dont think it is just overeating, I think [the] economic situation does have a big impact, he told the PA news agency.

Commenting that low-income families struggle the most, he said: It is difficult for some families with a lot of children who want to eat healthy, and they live on a street where it is all fast food and 1.99 for a family meal.

Some healthy food products can certainly be expensive, but there are also ways to save money at the supermarket and still eat nutritionally-balanced meals that will leave you feeling full and energised.

Here are a few nutritionist-backed tips, after the Government revealed its new strategy to tackle obesity and get the nation fit and healthy last month.

Maximise on pulses.: Pulses such as beans, lentils and peas are a cheap, low-fat source of protein, fibre, vitamins and minerals. They also count as part of your government-recommended five daily portions of fruit and vegetables.

Youd be surprised at how affordable and how far beans and pulses can stretch, says nutritionist Jenna Hope, who believes they are a great dietary source of protein, B-vitamins and fibre. To get more for your money, try buying the dried varieties.

Utilise frozen fruit and vegetables.: Your five-a-day dont have to come from expensive organic veg shops with fresh, loose produce.

Frozen fruits and vegetables are often just as nutritious as fresh, so theyre a good alternative when thinking about cheap dinner ideas, says Rob Hobson, nutritionist at Healthspan.

Frozen fruits can be added to healthy breakfast smoothies and puddings, while vegetables such as peas, cauliflower and sweetcorn can be added to many different dishes, including soups and stews.

Eat canned fish.: Cant afford fresh salmon from the fishmonger? Canned fish is a great cheap way to get your omega-3 fix, says Hope. Omega-3 is a fatty acid that plays a key role in brain functioning, and gut and bone health in the body.

Try opting for canned salmon and mackerel rather than the fresh varieties, she adds, as these can often work out several pounds cheaper.

Plan ahead.: Hobson believes that the best way to manage your food budget is to map out what youre going to eat across the week that way, you wont be tempted to rely on oven chips when youre stuck for inspiration.

Think about how you can use leftovers the next day and turn them into another interesting dish too, Hobson adds. For example, a pot of chilli can be used as a lunch filling to make Mexican wraps. Simply add sour cream, grated cheese and a little avocado.

Utilise the whole vegetable in cooking.: Root-to-stem eating encourages you to use every edible part of plant, including the leaves, skin, seeds and stalks.

For example, you could use cauliflower leaves and carrot tops in soup, roast the seeds of a butternut squash with salt and oil for snacking, and use vegetable peel to make homemade stock, says Hope.

According to Hope, the less you throw away, the further your weekly shop will go and not only is it great for the environment, but it will save you money in the long run too.

Editors note: first and foremost - and rarely have I written down these words with more sincerity - I hope this finds you well.

Almost certainly you are here because you value the quality and the integrity of the journalism produced by The Yorkshire Posts journalists - almost all of which live alongside you in Yorkshire, spending the wages they earn with Yorkshire businesses - who last year took this title to the industry watchdogs Most Trusted Newspaper in Britain accolade.

And that is why I must make an urgent request of you: as advertising revenue declines, your support becomes evermore crucial to the maintenance of the journalistic standards expected of The Yorkshire Post. If you can, safely, please buy a paper or take up a subscription. We want to continue to make you proud of Yorkshires National Newspaper but we are going to need your help.

Postal subscription copies can be ordered by calling 0330 4030066 or by emailing subscriptions@jpimedia.co.uk. Vouchers, to be exchanged at retail sales outlets - our newsagents need you, too - can be subscribed to by contacting subscriptions on 0330 1235950 or by visiting http://www.localsubsplus.co.uk where you should select The Yorkshire Post from the list of titles available.

If you want to help right now, download our tablet app from the App / Play Stores. Every contribution you make helps to provide this county with the best regional journalism in the country.

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Body coach Joe Wicks: Family finances impact on healthy living - Yorkshire Post

Keep your kids active and healthy as they head back to school – Kingsport Times News

All around the country, kids are heading back to school or getting used to virtual learning. Everyones summer pretty much went by in a blur; most parents are either jumping for joy or dreading getting back to the daily grind of normalcy.

As parents, we are making sure we get mental learning underway with our children, but lets not forget the physical activity. Science supports that physical activity enhances brain function and cognition, both of which improve academic performance.

Once school resumes on campus, keep the kids active when they get home. Instead of heading straight for the television, encourage your child to play a game of catch with a friend, skip rope, shoot some hoops, ride a bicycle, dance or even play a game of hopscotch. Join in on activities with your child. This will benefit you along with your child. Watching their parent make healthy choices and give their kids an opportunity to talk about their day will reduce childrens anxiety and stress levels. After working up an appetite, create a healthy meal together in the kitchen. Homemade pizza is an easy go-to. Start with a whole wheat or cauliflower crust, add tomato sauce and then choose some healthy toppings such as cheese, spinach, veggies and leaner meat options. Serve a slice with a tossed salad and you have a quick and healthier dinner option.

If your childs school resumes online, keep the same mindset keep kids active. Take 5-10 minute breaks between class subjects and do different exercises, stretches or activities. Reach out to your childs P.E. teacher to get some at-home activities that are age- appropriate. Throughout the day, help keep your childs energy levels up, which will improve the mind and mood. Reinforce a healthy atmosphere by incorporating a healthy breakfast, lunch and snack daily. Healthy foods include whole grain waffles or eggs, baked chicken nuggets or ham and cheese wraps, pieces of fruits/veggies or granola bars.

Exercise is beneficial for cognition because it increases blood and oxygen flow to the brain and also creates increased levels of norepinephrine and endorphins, resulting in a reduction of stress and an improvement in mood. With the uncertainty of these days, this is really important to your childs daily routine.

Just like you, your child doesnt need to log 30 to 60 minutes in the gym or in a specific exercise class. A game of tag here, a bike ride there are both fine. Short bursts of activity, with periods of rest in between, are actually the way our body was designed to move. Its not a bad idea to join your child in a game of tag or a trip around the block on your bicycle.

When the entire family works together, fitness and health are both fun and doable. For help keeping your family healthy, please refer to the Healthy Kingsport website at http://www.healthykingsport.org.

Healthy Kingsport is a nonprofit organization dedicated to creating a community that actively embraces healthy living by promoting wellness, enhancing infrastructure, and influencing policy. Aiesha Banks is its executive director. She can be reached at abanks@healthykingsport.org.

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Keep your kids active and healthy as they head back to school - Kingsport Times News

8 Simple Ways to Improve Your Posture While You’re Working From Home – POPSUGAR

Regardless if you're a fan of working from home, it's the norm for many for the foreseeable future, and we've all started to adjust to new routines. That means sleeping in a few extra minutes because your commute is gone, only planning Zoom outfits from the waist up, and creating makeshift desks in whatever room has the fewest number of distractions. But unlike the ergonomically designed workspaces in an office, home workstations can be less-than-optimal for your posture.

"Poor posture creates excessive pressure and stress on your spinal joints and muscles, which leads to tension, fatigue, and pain," Wilson Wang, DC, a chiropractor in Seattle, told POPSUGAR. And because working from home blurs the line between work and living spaces, it's easier to work longer hours. "That is diminishing our opportunities for movement, which is healthy for our joints and muscles and relieves stress," Wang explained.

Added Nora St. John, MS, NCPT, education program director for Balanced Body: "For many of us, working from home may mean using a laptop on the dining room table or the couch, which often puts our body out of alignment for extended periods of time. This can lead to pain in the neck, shoulders, hips, or lower back."

If your back is feeling especially achy these days, there are ways to relieve some of that pressure and save yourself long-term discomfort. Ahead are eight ways to combat bad posture while working from home, all from the comfort of where else? your home.

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8 Simple Ways to Improve Your Posture While You're Working From Home - POPSUGAR

What are you doing to maintain your mental health during the pandemic? Your responses. – The Dallas Morning News

Recently in the Living Our Faith feature, we asked readers to respond to the question: What are you doing to maintain your mental health during the pandemic? The following are some of the thoughtful responses.

This column is part of our ongoing opinion commentary on faith, called Living Our Faith. Find this weeks reader question and get weekly roundups of the project in your email inbox by signing up for the Living Our Faith newsletter.

What I missed most from being safe at home was interaction with other people. So two weeks into the stay-at-home order, our Sunday school class of 50- to 60-year-olds learned how to Zoom. We meet virtually each Sunday for our time of Bible study and fellowship. Just talking to each other about what we are feeling and how we are dealing with things is really helping us. Our faith is strong and we know we are not alone as we go through this pandemic.

Danita White, Grand Prairie

On March 10, I weighed 190 pounds and decided to lose weight through consistent exercise and a revised food plan, in conjunction with the addition of supplements. I visited with a dietician who addressed a food plan consisting of fish, vegetables, fruits, protein drinks and the noted supplements. She developed a training program consisting of cycling, treadmill walking-running, weight training, crunches, etc., (all at home, in my garage I converted into a workout room).

I dropped to 168 pounds and have now stabilized between 172-174, which is my ideal weight. There are no words to describe how wonderful I feel. I occasionally have a glass of wine, but my desire for alcohol has completely faded. Reading books and listening to motivational speakers on YouTube have contributed to extraordinary physical and mental well-being.

J.D. Gonzales, Dallas

Im not sure I would call what were doing as maintaining mental health as much as I would call it moving forward or just maybe just plain living day-to-day. We have kept up our routines with household chores, TV starts with the evening news during the week unless theres a sporting event and a walk each day.

We keep up with events and people through emails, phone calls, Zoom. We have tried new things like a Zoom wedding, online courses and connecting with family and friends with Zoom. We like to travel, which isnt happening now so instead, I plan what Ive named field trips each week. Its a trip by car, somewhere close that we havent been, it gets us out for a few hours and we see something new.

I think what has helped us through this difficult time is trying new ways to keep moving forward with our lives and keeping connections with family and friends. Speaking of connecting, I have written letters and emailed people I havent been in touch with lately, thats been fun. I set a goal of 3 per week since being at home, think of it as a holiday card list without the holiday.

Perri Brackett, Lewisville

I have cooked a lot of healthy food, trying new recipes, and grown a big herb garden, pickling cucumbers we grew in the garden. I have wanted to write a country western song and have put pen to paper to try to start that. Reading a lot of books, Zooming with friends and bicycling. Reading a lot of political commentary and learning more about implicit bias and the history of systemic racism in the U.S.

Elena Bourke, Plano

We received a number of responses from members of the Bahai Faith to a prior question about what people of faith can do to heal racial division. The following is a thoughtful example.

As a Bahai, I believe the fundamental truth that humanity is one, but it is not enough simply to believe this in our hearts, we need to create the moral imperative to act, and to view all aspects of our personal, social and institutional lives through the lens of oneness and justice.

It requires the participation of Americans of every race and background, for it is only through principles of love, reciprocity and inclusive participation that new moral and social directions can emerge. We should also remember that our diversity is our strength, and it is simply beautiful, like a garden with flowers of different kinds, colors and perfumes.

The role of religion as an enduring source of insight concerning human purpose and action cannot be overemphasized in this process. All faith communities recognize that we are essentially spiritual beings. All proclaim some version of the Golden Rule, to love others as we do ourselves.

On a practical level, we are trying to ensure that each person we engage feels welcome to participate in our community activities. Some might attend devotional gatherings and eventually engage with us in study and service. Some families may first associate with us by engaging children or junior youth in their respective activities of childrens classes and junior youth groups, characterized by twofold moral purpose, to develop their inherent potentialities and to contribute to the transformation of society, through service to the community and engaging in social action and more involvement in the community life.

Kambiz Rafraf, Dallas

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What are you doing to maintain your mental health during the pandemic? Your responses. - The Dallas Morning News

First subject dosed with ZF874, a potential disease-modifying treatment for alpha-1-antitrypsin deficiency – Cambridge Network

AATD is a common genetic disorder, affecting around in 1 in 2000 people in Western countries, where a single mistake in the DNA encoding the protein alpha-1-antitrypsin (A1AT) causes both liver and lung disease.

Nearly all of the cases of AATD are caused by just a single mutation in the A1AT gene, known as the Z mutation. The Z mutation causes most of the A1AT to misfold, forming polymers that stay in the liver instead of being secreted into the blood where it plays a key role in protecting the lungs and other organs from the damaging effects of inflammation explained Jim Huntington, Professor at the University of Cambridge and Founder of Z Factor (pictured). The low levels of correctly-folded A1AT in the lungs results in the development of emphysema in nearly all AATD sufferers. At the same time, accumulation of Z-A1AT polymers in the liver can cause liver disease, sometimes manifesting as liver failure in newborns and more commonly cirrhosis and liver cancer as carriers of this mutation age.

ZF874 was developed with the help of a proprietary crystal structure solved by the Huntington lab. It is a novel compound that acts as a molecular patch for the faulty protein, allowing it to fold correctly, thereby simultaneously relieving the liver burden of polymer accumulation and providing fully-functional Z-A1AT in the circulation to protect the lungs. In mice genetically engineered to express human Z-A1AT in their livers, oral doses of ZF874 were able to substantially increase levels of correctly folded protein in the blood and to completely eliminate accumulation of misfolded protein in the liver.

We are excited to have dosed our first human volunteer with ZF874, said Trevor Baglin, Chief Medical Officer for Z Factor. This trial is designed to allow us to determine how safe and effective it is at raising Z-A1AT levels in humans in a short period of time. We expect to have top-line results for this potentially disease-modifying treatment in subjects carrying the Z mutation by the end of this year.

ZF874 has an excellent safety profile in preclinical toxicology studies and is suitable for oral dosing, ideal for the long-term treatment of patients with AATD, and eventually in the 2-3% of the population carrying a single copy of this mutant gene, who are also at increased risk of both liver and lung disease.

Only one other program targeting Z-A1AT folding is currently in the clinic, from the US pharmaceutical company Vertex (NASDAQ: $VRTX), who expect to report data on a similar time-frame to Z Factor.

The burden of disease caused by the Z-A1AT genetic defect has largely gone under the radar, said David Grainger, Executive Chairman at Z Factor. As many as a third of all emphysema and cirrhosis cases in Western countries, amounting to millions of patients, can trace the origins of their disease to this single error in their DNA. There is a huge unmet clinical need here.

Z Factor was founded in 2015, as a spin-out from the University of Cambridge, armed with the worlds first detailed structure of the Z-A1AT polymer from the Huntington laboratory. Cambridge Enterprise, the commercialisation arm of the University of Cambridge, licensed the technology into Z Factor. Cambridge Enterprise also participated in both the seed round and the Series A round, which was led by Medicxi, with Cambridge Innovation Capital participating.

The funding allowed the team to leverage this window onto the folding defect caused by the Z mutation, working in collaboration with the local out-sourced discovery platform company, RxCelerate, to create ZF874. Entry into the clinic marks a significant step in the development pathway for a drug from concept to approval.

We are one important step closer to delivering a drug that will not only treat the diseases associated with AATD, but that, given prophylactically, may ensure carriers of the Z mutation never develop these diseases in the first place said Huntington.

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First subject dosed with ZF874, a potential disease-modifying treatment for alpha-1-antitrypsin deficiency - Cambridge Network

These Enzyme-Mimicking Polymers May Have Helped Start Life on Earth – SciTechDaily

The micrograph shows uniform nanoparticles under 10nm in diameter. Credit: Tony Z. Jia, ELSI

Earth-Life Science Institute scientists find that small highly branched polymers that may have formed spontaneously on early Earth can mimic modern biological protein enzyme function. These simple catalytic structures may have helped jump start the origins of life.

Most effort in origins of life research is focused on understanding the prebiotic formation of biological building blocks. However, it is possible early biological evolution relied on different chemical structures and processes, and these were replaced gradually over time by eons of evolution. Recently, chemists Irena Mamajanov, Melina Caudan and Tony Jia at the Earth-Life Science Institute (ELSI) in Japan borrowed ideas from polymer science, drug delivery, and biomimicry to explore this possibility. Surprisingly, they found that even small highly branched polymers could serve as effective catalysts, and these may have helped life get started.

In modern biology, coded protein enzymes do most of the catalytic work in cells. These enzymes are made up of linear polymers of amino acids, which fold up and double-back on themselves to form fixed three-dimensional shapes. These preformed shapes allow them to interact very specifically with the chemicals whose reactions they catalyze. Catalysts help reactions occur much more quickly than they would otherwise, but dont get consumed in the reaction themselves, so a single catalyst molecule can help the same reaction happen many times. In these three-dimensional folded states, most of the structure of the catalyst doesnt directly interact with the chemicals it acts on, and just helps the enzyme structure keep its shape.

Metal sulfide enzymes could have originated from globular metal-sulfide/hyperbranched polymer particles. Credit: Irena Mamajanov, ELSI

In the present work, ELSI researchers studied hyperbranched polymers tree-like structures with a high degree and density of branching which are intrinsically globular without the need for informed folding which is required for modern enzymes. Hyperbranched polymers, like enzymes, are capable of positioning catalysts and reagents, and modulating local chemistry in precise ways.

Most effort in origins of life research is focused on understanding the prebiotic formation of modern biological structures and building blocks. The logic is that these compounds exist now, and thus understanding how they could be made in the environment might help explain how they came to be. However, we only know of one example of life, and we know that life is constantly evolving, meaning that only the most successful variants of organisms survive. Thus it may be reasonable to assume modern organisms may not be very similar to the first organisms, and it is possible prebiotic chemistry and early biological evolution relied on different chemical structures and processes than modern biology to reproduce itself. As an analogy with technological evolution, early cathode-ray TV sets performed more or less the same function as modern high definition displays, but they are fundamentally different technologies. One technology led to the creation of the other in some ways, but it was not necessarily the logical and direct precursor of the other.

If this kind of scaffolding model for biochemical evolution is true, the question becomes what sort of simpler structures, besides those used in contemporary biological systems, might have helped carry out the same sorts of catalytic functions modern life requires? Mamajanov and her team reasoned that hyperbranched polymers might be good candidates.

The team synthesized some of the hyperbranched polymers they studied from chemicals that could reasonably be expected to have been present on early Earth before life began. The team then showed that these polymers could bind small naturally occurring inorganic clusters of atoms known as zinc sulfide nanoparticles. Such nanoparticles are known to be unusually catalytic on their own.

As lead scientist Mamajanov comments, We tried two different types of hyperbranched polymer scaffolds in this study. To make them work, all we needed to do was to mix a zinc chloride solution and a solution of polymer, then add sodium sulfide, and voila, we obtained a stable and effective nanoparticle-based catalyst.

The teams next challenge was to demonstrate that these hyperbranched polymer-nanoparticle hybrids could actually do something interesting and catalytic. They found that these metal sulfide doped polymers that degrade small molecules were especially active in the presence of light, in some cases they catalyzed the reaction by as much as a factor of 20. As Mamajanov says, So far we have only explored two possible scaffolds and only one dopant. Undoubtedly there are many, many more examples of this remaining to be discovered.

The researchers further noted this chemistry may be relevant to an origins of life model known as the Zinc World. According to this model, the first metabolism was driven by photochemical reactions catalyzed by zinc sulfide minerals. They think that with some modifications, such hyperbranched scaffolds could be adjusted to study analogs of iron or molybdenum-containing protein enzymes, including important ones involved in modern biological nitrogen fixation. Mamajanov says, The other question this raises is, assuming life or pre-life used this kind of scaffolding process, why did life ultimately settle upon enzymes? Is there an advantage to using linear polymers over branched ones? How, when and why did this transition occur?

Reference: Protoenzymes: The Case of Hyperbranched Polymer-Scaffolded ZnS Nanocrystals by Irena Mamajanov, Melina Caudan and Tony Z. Jia, 13 August 2020, Life.DOI: 10.3390/life10080150

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These Enzyme-Mimicking Polymers May Have Helped Start Life on Earth - SciTechDaily

Researcher John Craig Venter Is Awarded the 2020 Edogawa-NICHE Prize for His Accomplishment in Human Genome Research – Business Wire

TOKYO--(BUSINESS WIRE)--The Edogawa NICHE Prize for the year 2020 has been awarded to Dr. John Craig Venter for his contribution to research and development pertaining to the Human genome. This honor reflects Dr. Venter's lifetime accomplishments in the power of the genomics and specifically in the identification of the human genome which has radically transformed healthcare according to Prof. Gary Levy, chair, Edogawa NICHE awards committee (www.edogawanicheprize.org).

Edogawa NICHE Prize was Instituted in 2018, by the Jinseisha trust, and the Nichi-In Centre for Regenerative Medicine (NCRM), which honours scientists or clinicians whose contributions lead to the development of prevention, diagnosis or treatment of any disease, through an inter-disciplinary approach. Alumni of the Fujio Cup Quiz, a part of NCRM NICHE, (www.ncrmniche.org), have priority for nomination, a unique feature of this prize. Previous awardees include Prof James Till, University of Toronto, Canada for discovery of stem cells (2018) and Dr. Steven Rosenberg, National Institutes of Health, USA for his groundbreaking work on T-lymphocyte immunotherapy (2019).

Dr. Venter was born in Salt Lake City Utah on October 14, 1946. He started his college education at the College of San Mateo, CA and later studied Biochemistry in University of California, San Diego under biochemist Nathan O. Kaplan. After obtaining a PhD in Physiology and Pharmacology from UCSD, he became a Professor at the State University of New York and joined the National Institute of Health in 1984. He has founded Celera Genomics, The Institute of Genomic Research (TIGR), J.Craig Venter Institute (JCVI) and co-founded Human Longevity Inc and Synthetic Genomics.

His path breaking sequencing of the first human genome with the Human Genome Project further progressed to transfecting a cell with a synthetic chromosome, a feat that has opened up opportunities to develop novel solutions not only in healthcare, but also in environmental issues and energy domain.

The awarding of the Edogawa NICHE prize to Dr Venter is the most recent in a string of honors including United States Medal of Science (2008), Gardner Foundation International Award (2002), Paul Erlich and Ludwig Darmstaedter Prize (2001) and the King Faisal International Award of Science (2001). He was listed on Time Magazines list of the most influential people in the world.

The award ceremony date will be announced later.

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Researcher John Craig Venter Is Awarded the 2020 Edogawa-NICHE Prize for His Accomplishment in Human Genome Research - Business Wire

From stem cells to islets hope for treatment of type 1 diabetes – News – The University of Sydney

According to Professor Liddle, this study used stem cells derived from human umbilical vein and human fat that were re-programmed to generate human islet-like organoids (HILOs).

Pancreatic islets are regions in the pancreas responsible for the production of hormones and insulin.

Pancreatic islets contain multiple cell types, not just insulin-producing beta cells. The research team created three-dimensional HILOs that not only include beta-like cells (the cells that produce, store and release insulin in the islets of the pancreas), but also other supporting cell types found in normal islets, said Professor Liddle.

Under the microscope, and using gene sequencing analysis, we are able to show that the three-dimensional HILOs are very similar to human islets. When the HILOs are transplanted into diabetic mice, they secrete insulin when blood glucose levels are high, just as normal islets would.

While human pancreatic islet transplantation has been a major advancement in treating severe cases of type 1 diabetes, the availability, quality and limited cellular longevity of this approach limits its application.

Pancreatic islet transplantation currently involves implanting insulin-producing islet cells from a deceased human donor into the liver of a person with type 1 diabetes. When successful, the procedure can control blood glucose levels, reduce the frequency and severity of hypoglycaemic episodes and potentially eliminate the need for regular insulin injections. A number of transplants are usually needed, and immunosuppressant drugs to prevent the immune system from attacking the transplanted cells are also required.

While the procedure is now funded by the Australian Government, pancreatic islet transplantation is currently limited to people with severely unstable type 1 diabetes, particularly those for whom insulin therapy alone is not effective and who experience recurrent and severe hypoglycaemic episodes.

Professor Philip OConnell is Executive Director at The Westmead Institute for Medical Research and pioneered pancreatic islet transplantation in Australia. Almost 20-years ago, he led Australias first pancreatic islet transplantation trials at Westmead Hospital and The Westmead Institute for Medical Research. Today, he continues his research, aiming to improve this procedure and develop islet transplantation as a mainstream treatment for type 1 diabetes.

Professor OConnell, who was not involved in this research study, said, Pancreatic islet transplantation has saved hundreds of lives around the globe however, it has its limitations. For example, pancreatic islets are taken from deceased donors, and the wait for donor islets can be lengthy. Once donor islets are obtained, not all are suitable for transplantation.

This research indicates the potential to alleviate some of these issues. Stem cells derived from readily available human tissues can be expanded then re-programmed into potentially unlimited numbers of islets that are suitable for transplantation.

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From stem cells to islets hope for treatment of type 1 diabetes - News - The University of Sydney

County sheriff offers components for improved policing – Press of Atlantic City

The tragic death of George Floyd and the ensuing civil unrest in our country has once again placed the spotlight on police use of force and the policies and practices that govern it.

There has been a demand for reform and defunding the police to effect drastic change within law enforcement culture. I wish to share my perspective on this paradigm, as a career law enforcement officer who has served the citizens of Atlantic County in two separate agencies for over 25 years.

As a retired lieutenant from the Atlantic City Police Department and as the sheriff of Atlantic County, I firmly support our police and can tell you from experience that the outstanding police officers far outnumber those who are unfit to serve in our communities.

However, we cannot continue to allow events like these to occur without taking meaningful inventory of our policies, tactics and training to enhance our efficiency and effectiveness as guardians and safe keepers of our communities. As sheriff, I am constantly looking for ways to improve our delivery of services and keep our officers and communities safe. This is a complex and layered issue that requires funding and commitment from local and federal governments to facilitate and sustain meaningful and positive change. Additionally, there are human factors that need to be addressed that will result in better policing. Here are some fundamental components that, in my opinion, would support systemic change:

Mandatory pre-employment screening, mental health wellness and resilience training: Psychological fitness should begin at the hiring stage and continue throughout an officers career to include mental health checkups and resiliency training. Officers will be exposed to repetitive trauma throughout their careers. It is paramount they are given the skills to adapt and overcome these experiences for the sake of their own mental health, to be present for their families and to view and serve their communities through an empathetic lens.

Standardize physical fitness requirements: Officers should be physically prepared to respond to any situation they may encounter. Physical stress is a huge part of the job that takes its toll on an officers overall health. The frequency of fight or flight in the typical officers experience is significantly higher than the average civilian. That stress response causes massive dumps of cortisol for the officer, which ultimately leads to numerous serious health concerns. Physical fitness is a critical requirement for longevity and adaptation to stress from the job.

Weekly tactical training: Training is also a crucial part of the equation to be an effective officer. They are expected to perform under high-stress, rapidly unfolding circumstances much like professional athletes. However, in most cases, they do not receive the support or time to build their skill set individually or in terms of team tactics. Standardized tactical training should be mandatory every week. Consistent training will result in increased officer confidence under pressure and improvements in overall performance.

Age and education restrictions: The emotional intelligence, life experience and education of an officer can impact his or her ability to deal with certain types of critical incidents. Science suggests the human brain is not fully developed until 24 years of age, yet there are no uniform hiring requirements to reflect these findings. A hard look should be given at establishing requirements raising the minimum age for new hires, creating higher education standards and placing limits on the maximum age of an officer, especially as it relates to physical fitness capabilities.

Community engagement: Community engagement falls squarely on the shoulders of the agency and should become part of every police organization. In other words, it should be part of the daily routine of every officer from top to bottom. This will allow the community to become familiar with their local police officers and form mutual respect for one another.

Leadership and accountability: There are many great leaders in our local and state police departments, but enhanced training and experience should apply to them as well. Professional development should be consistent and on-going to truly produce visionary leaders. Leaders who develop self-awareness inevitably create self-management skills and see personal and organizational accountability as a high priority. By implementing standardized and consistent self-assessment, training, and community engagement, we will create a greater police professionalism and community relationships built on trust and transparency which, ironically, will result in more support for the police and a healthier and safer community for all.

ERIC SCHEFFLER

Atlantic CountySheriff

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County sheriff offers components for improved policing - Press of Atlantic City

Could the latest in OLED lighting be heading into an RV? – LEDs Magazine

The only thing missing from the serenity is an OLED. (Photo credit: Image by Steve Adcock via Pixabay; used under free license for commercial or non-commercial purposes.)

OLED proponents have long struggled to make substantial inroads into the lighting market, but they continue to push, and to identify new segments where the technology could be just right. The latest example: OLEDWorks wants to outfit recreational vehicles yes, RVs with the technologys soft and sleek illumination.

Its a market that excites the Rochester, NY-based company with growth potential, because as director of user experience Kathleen Vaeth noted in a recent blog post, RV sales are on the rise as people rethink their vacations in the era of social distancing and international travel restrictions, and start heading to national parks and the like.

On top of that, thin and flexible OLEDs are simpatico with modern RV interior design which Vaeth notes, has come on in leaps and bounds.

First, our obligatory, quick refresher: OLEDs (organic light-emitting diodes) are different from LEDs in that OLEDs are a thin material that entirely lights up in response to an electric charge, whereas LEDs are single light points. Invented at Rochester-based Eastman Kodak in 1987 (OLEDWorks was founded 10 years ago by former Kodak scientists), OLEDs have long failed to live up to the expectation that they will revolutionize lighting by literally weaving into the fabric of everything from lamps and fixtures to ceilings, walls, furniture, fashion, building faades, you name it. One problem is that the design of LED fixtures continues to improve; and OLEDs have trailed LEDs in energy efficiency.

But OLEDs are declining in price, improving in efficiency and slowly creeping into general illumination.

They are also finding specialty, niche, and architectural design uses. OLEDWorks will be supplying tail lights to Audi, for example.

RVs could be next, if OLEDWorks has its way. The company certainly thinks theres a big need.

The interior design has progressed significantly in recent years, allowing travelers to bring the comforts of home along with them, waxes Vaeth. High-quality cabinets, quartz countertops and spacious kitchens, leather seating, flat-screen TVs, air conditioning, solar power, and Wi-Fi connectivity are common features in todays models. But what about comfortable lighting?

Of course, she has the answer: The artificial lighting in these units have not progressed as much by comparison. At OLEDWorks, we think that this is the next frontier for designers to address and continue the revolution of the indoor RV space.

Vaeth points out that OLEDs, with their slim profile, fit the tight spaces of an RV, and also reduce overall vehicle weight, which reduces fuel consumption.

OLED lighting panels, measuring 1.4 millimeters in thickness and weighing less than 40 grams, offer an ultracompact and lightweight form factor that opens up the possibility of easily integrating lighting on horizontal and vertical surfaces, or in compact locations such as under cabinets and in drawers, she notes.

The thinness provides an aesthetic complemented by a mirror finish in the off state that can be used to accent the space, or blend into the background, Vaeth adds. She also trots out an attribute that OLED supporters often ascribe to the technology: The light is soft, diffuse, and glare free. Likewise, she notes that OLEDWorks thin panels avoid the blue spectrum that can undermine sleep when used at night, and that it avoids ultraviolet (UV) wavelengths which can be damaging.

This makes OLEDs compatible with lighting trends emphasizing lighting design for sustainability and human health, she notes.

Vaeths blog noticeably does not identify any signed-up RV customers. As OLED vendors hit the RV highway in search of deals, they will undoubtedly run into LED competitors, who offer many similar benefits, with LEDs probably still maintaining an edge in efficiency and in longevity. OLEDs might just have the leg up in design advantages, especially considering the space restrictions of an RV.

Describing the state of RV lighting today with technologies including incandescent, compact fluorescent, and LEDs, Vaeth notes, Most fixtures are small and compact but tend to be integrated into ceilings as recessed lighting or circular flush-mounted fixtures with push button switches. Specialized fixtures integrated for closer, more flexible illumination in spaces such sleeping areas can often be overly bright, or too dim. This can make for an illumination experience, even in the most state-of-the-art models, that is uneven with sharp contrast and shadows, and high in glare, which can cause discomfort and eye strain.

To paraphrase Vaeth, theres nothing like an OLED to take care of those shortcomings.

Wi-Fi. Quartz countertops. Flat-screen TVs. OLEDs. Ah, the great outdoors.

MARK HALPERis a contributing editor for LEDs Magazine, and an energy, technology, and business journalist (markhalper@aol.com).

For up-to-the-minute LED and SSL updates, why notfollow us on Twitter? Youll find curated content and commentary, as well as information on industry events, webcasts, and surveys on ourLinkedIn Company Pageandour Facebook page.

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Could the latest in OLED lighting be heading into an RV? - LEDs Magazine

Coronavirus may have come from bats; could they also hold clues to treatments? – Health24

Bats have been blamed as a possible source of the new coronavirus pandemic ravaging the globe. But they might also point to possible ways out of it.

Scientists say the winged mammals' immune systems may offer clues on how to fight the new coronavirus and other dangerous viruses in humans.

"Humans have two possible strategies if we want to prevent inflammation, live longer and avoid the deadly effects of diseases like Covid-19," explained study lead author Vera Gorbunova, a professor of biology at the University of Rochester in New York. "One would be to not be exposed to any viruses, but that's not practical. The second would be to regulate our immune system more like a bat."

Resistance and longevity

Many deadly viruses that affect people are believed to have originated in bats, including rabies, Ebola and SARS-CoV-2, the strain that causes Covid-19. But bats have evolved a secret weapon: They're better able to tolerate viruses than humans and other mammals.

"We've been interested in longevity and disease resistance in bats for a while, but we didn't have the time to sit and think about it," Gorbunova said in a university news release.

"Being in quarantine gave us time to discuss this, and we realised there may be a very strong connection between bats' resistance to infectious diseases and their longevity. We also realised that bats can provide clues to human therapies used to fight diseases," she explained.

Typically, a species' lifespan is associated with its body size. The smaller a species, the shorter its lifespan. But many bat species have lifespans of 30 to 40 years, which is impressive for their size, the authors noted in a review article published recently in Cell Metabolism.

Bats' longevity and tolerance to viruses may be due to their ability to control inflammation, which is involved in both ageing and disease. Viruses, including Covid-19, can trigger inflammation.

Our bodies overreact

With Covid-19, this inflammatory response goes "haywire", Gorbunova said. In fact, in many cases it is the inflammatory response that kills the patient, more so than the virus itself.

"The human immune system works like that: Once we get infected, our body sounds an alarm and we develop a fever and inflammation. The goal is to kill the virus and fight infection, but it can also be a detrimental response as our bodies overreact to the threat," Gorbunova said.

In contrast, bats' immune systems control viruses without mounting a strong inflammatory response.

There are several possible reasons why bats evolved to fight viruses and live long lives. Flight may be one of them, the researchers noted.

Constant exposure to viruses

Bats are the only mammals that can fly, which required them to adapt to rapid increases in body temperature, sudden surges in metabolism and molecular damage. These adaptations may also assist in disease resistance, the study authors suggested.

Another factor is that many species of bats live in large, dense colonies, and hang close together on cave ceilings or in trees. Those conditions are ideal for transmitting viruses and other pathogens.

According to Andrei Seluanov, a biology professor at the University of Rochester, "Bats are constantly exposed to viruses. They are always flying out and bringing back something new to the cave or nest, and they transfer the virus because they live in such close proximity to each other."

This means that bats' immune systems are continuously adapting to deal with new viruses. Studying bats' immune systems could lead to new ways to fight aging and diseases in humans, the researchers said.

Image credit: Igam Ogam, Unsplash

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Coronavirus may have come from bats; could they also hold clues to treatments? - Health24

The Dream Is Over – KNPR

A global nightmare put an end toLe Rve, French for The Dream. But the aquatic revue at Wynn Las Vegas had a charmed life for most of its 15 years, provided you could keep up with that ever-shifting quality people associate with their own dreams.

Granted, you dont expect a lot of solid footing in a water show, where the audience surrounded the high-divers and the acrobatics staged in and above a pool. And only in Las Vegas would we already have one.

When it opened in 2005,Le Rvewas initially dismissed as a bungled knock-off of Cirque du SoleilsO. But on it ran, rarely sitting still as it worked to distance itself. The hotel was always announcing some new addition or revision, with a lot of chefs in the kitchen. And some of the most specific decisions, down to the music and costumes, were made by the chef who had a whole company to oversee: hotel namesake Steve Wynn.

August 14 brought the news thatLe Rvewould remain closed even after the COVID-19 pandemic subsides, ending another old-Vegas anomaly: The show was 100 percent owned by Wynn Resorts, and its cast and crew were hotel employees. That didnt mean much to ticket-buyers, unless they stepped back to notice that nearly every other theater space in town was leased to independent producers who took on most of the risk. But its also a likely explanation for why the hotel chose not to wait out the pandemic.

Brian Burke was the shows artistic director for six years, and is now a producer on NBCsAmericas Got Talent. He says that compared to California, Nevada officials havent done a good job of coordinating a reopening plan with its entertainment industry. You cant buy a show ticket, but you can sit down in the restaurant next to theLe Rvetheater and have dinner, he notes. If a show isnt even allowed to test whether it could, say, run three times a day for a one-third capacity house, Nobody can sustain paying people for that long.

It takes a good memory now to recall times so good the Strip could havetwomultimillion-dollar aquatic shows, and the biggest challenge was trying to make them stand apart from one another.Le Rvewasnt supposed to be a direct competitor ofO. It evolved from plans for a short outdoor water show to be staged several times a day, and the original $12 million budget was a fraction of Cirques. But it evolved into more of what people expected it to be, a schizophrenic mix of what was then expected of Cirque-era Vegas, and the restless ambition of Steve Wynn and former Cirque director Franco Dragone.

People were dumping money down the street atKA(the Cirque show that cost at least $165 million), and Franco wanted to make a human-based show, Burke recalls. But Wynn pumped at least another $25 million more into makingLe Rvelighter and brighter. His obsession some would call it micromanaging with the aquacade hearkened back to an earlier, pre-corporate era of Las Vegas, when properties were defined by their entertainment and the colorful figures in charge of it.

Wynn and Dragone had already transformed the Strip with CirquesMystereandO, but their relationship was, well, complicated, and for a time Dragone was out of the picture altogether. I prefer Cezanne, and he loves Matisse, Dragone once explained.

Changes came early and often, starting with a quick and drastic overhaul in the week after Dragone shocked some patrons of a charity premiere by showing them pregnant women doing belly flops and fishing nets dredging up eerie reminders of another global catastrophe the previous years giant tsunami. (I am not the same man I was in 98, Dragone explained. I have seen 9/11. I have seen the Iraq war, Katrina. Yes,Le Rveis darker, but why not?). And it was still being tweaked by yet another creative hand, Broadway director Philip McKinley, almost up to the week in February 2018 when Wynn resigned as chairman of his company amid accusations of sexual misconduct.

The friction sort of became the gold in a way, Burke says now. Those guys are dreamers, theyre big thinkers, and I feel the influence of working with them.

Le Rvewas sure sexier than its Cirque counterpart, once it settled into a storyline focused on the erotic longings of a beautiful dreamer, as the old song goes. "It's very hard to take the Cirque references out," Wynn noted in late 2007, as he explored new corners of pop culture by recruiting Maksim Chmerkovskiy, ofDancing with the Stars, to add ballroom dancing to the aquatic mix.

Everyone was there as a collective, and even though it was run by a corporate entity, it was intimate, personal, hands-on, Burke says. It was a family environment, and everyone really believed in it. Everybody didnt become a number. And thats why people have such passion about the fact that it closed.

The price of longevity is becoming just another fixture on the Strips landscape, one that locals tend to forget until visitors came to town. But, unlike the faded showgirl opusJubilee, no one no one imaginedLe Rvewould close after only 15 years.Jubileewas another rare hotel-owned production, and its closing was said to owe less to the waning appeal of showgirls than the desire to get all those cast and crew members off the hotel payroll. It wouldnt be wild speculation to wonder if, once the pandemic is over, an outside producer maybe even one named Dragone would turn the spigots back on and stage a new show on the water.

My ultimate hope would be that the pandemic ends, and Franco and I would be the ones to get to do the newLe Rve, Burke says. We dont just want to go in like a vulture, but its like a piece of your soul and your heart is there.

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The Dream Is Over - KNPR

Trellus Health Secures $5M Seed Funding to Transform Care for Chronic Conditions – BioSpace

NEW YORK, Aug. 20, 2020 /PRNewswire/ -- Trellus Health, a resilience-driven digital health solution for chronic conditions, today announced that it has raised $5 million of seed funding to transform the way chronic conditions are treated, with an initial focus in Inflammatory Bowel Disease (IBD), including Crohn's disease and ulcerative colitis. The round was led by Mount Sinai Health System(MSHS) and EKF Diagnostics, a global medical manufacturer of point-of-care and central lab devices and tests. Trellus has also entered into an exclusive multi-year contract with MSHS to commercialize its patent pending GRITT-IBDTM resilience assessment and personalized treatment methodology.

Ninety-percent of the United States' $3.3 trillion annual health care expenditure is for chronic diseases, with patients suffering from both chronic medical and mental health conditions costing twice as much, according to the CDC. Despite these cost implications, traditional care models fail to address the emotional well-being of people with chronic conditions, and access to expert interdisciplinary care resources to deliver specialist-level care is highly limited.

"We are transforming the way chronic conditions are treated by developing a resilience-driven connected care platform that integrates precision medicine with psychosocial care," said Monique Fayad, CEO of Trellus Health. "The traditional journey of medical care for people living with chronic conditions typically results in repeated costly, unplanned emergency room visits and hospitalizations, high rates of work absenteeism and lost productivity, as well as chronic disability and behavioral health issues. We're working to change this by focusing on building patients' resilience while integrating all partners in care, including employers, insurance plans, health systems, Trellus-certified GI providers, nurses, psychologists, and dieticians who can utilize Trellus Health's proprietary platform to effectively monitor and communicate with patients and their caregivers in real time."

The first chronic condition that Trellus Health will address is IBD, one of the costliest chronic conditions with a high mental health burden, affecting 3 million patients in the U.S.(7 million globally) and costing the U.S. healthcare system over $30 billion a year, according to the Cost of Inflammatory Bowel Disease: An Initiative From the Crohn's & Colitis Foundation 2019.Since 2016, the company's co-founders, Marla Dubinsky, MD, and Laurie Keefer, PhD, who together bring close to 50 years of experience managing IBD and serve as co-directors of the Mount Sinai IBD Medical Home, have integrated resilience-driven multi-disciplinary care into the management of IBD patients.

"Our research on over 200 IBD patients indicates that more than 70% believe their condition would be better managed if they had support for anxiety or depression," said Dubinsky, who along with being a co-founder and board member, is also a Professor of Pediatrics and Medicine, Chief of Division of Pediatric Gastroenterology and co-director of Susan and Leonard Feinstein IBD Clinical Center at Mount Sinai. "By personalizing care to address the psychosocial needs of all IBD patients and applying the latest evidence-based clinical approaches, we can help patients achieve disease control and enjoy a significantly improved quality of life."

Resilience-driven care incorporates positive psychology principles into all aspects of chronic disease management, with a focus on building acceptance, optimism, self-regulation, self-efficacy, and social support. Proven health benefits of resilience include increased longevity, cardiovascular, immune, and cognitive function, as well as physical well-being and reduced risk for depression and anxiety.

"Crohn's disease was discovered at Mount Sinai by Dr. Burrill Crohn nearly 100 years ago, and the System has made great strides in enhancing the the standard of care and outcomes for our patients," said Erik Lium, President, Mount Sinai Innovation Partners and Executive Vice President and Chief Commercial Innovation Officer at Mount Sinai. "We're pleased to partner with Trellus Health to advance commercial development of a resilience-driven approach and connected care model for treating IBD and other complex chronic conditions, making Mount Sinai's technology available to more patients."

"Dr. Keefer's important research utilizing the GRITTTM Method at the Mount Sinai IBD Center shows first-hand how resilience-driven multidisciplinary care significantly reduces unplanned care," said Julian Baines, CEO of EKF Diagnostics. "We are excited to support Trellus in helping millions of people reduce their disease burden and improve their overall well being."

About Trellus HealthTrellus Health is a leading pioneer in resilience-driven care for people with complex chronic conditions. Through its multidisciplinary connected care platform, Trellus coordinates expert whole-person care, including both clinical and behavioral health, to improve outcomes and to reduce healthcare costs for patients, employers, and the healthcare system. The Company leverages its patent-pending GRITT-IBDTM resilience assessment and personalized treatment methodology, developed at the Mount Sinai Health System, to support patient resilience and wellness for better outcomes. For more information on Trellus Health, visit http://www.trellushealth.com.

The resilience-driven connected care solution described is based on technology developed by Mount Sinai faculty and licensed to Trellus Health. Mount Sinai and Mount Sinai faculty members Marla Dubinsky, MD, and Laurie Keefer, PhD,have a financial interest in Trellus Health.

About the Mount Sinai Health SystemThe Mount Sinai Health System is New York City's largest academic medical system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai is a national and international source of unrivaled education, translational research and discovery, and collaborative clinical leadership ensuring that we deliver the highest quality carefrom prevention to treatment of the most serious and complex human diseases. The Health System includes more than 7,200 physicians and features a robust and continually expanding network of multispecialty services, including more than 400 ambulatory practice locations throughout the five boroughs of New York City, Westchester, and Long Island. The Mount Sinai Hospital is ranked No. 14 onU.S. News & World Report's"Honor Roll" of the Top 20 Best Hospitals in the country and the Icahn School of Medicine as one of the Top 20 Best Medical Schools in country. Mount Sinai Health System hospitals are consistently ranked regionally by specialty and our physicians in the top 1% of all physicians nationally byU.S. News & World Report.

For more information, visithttps://www.mountsinai.orgor find Mount Sinai onFacebook,TwitterandYouTube.

About Mount Sinai Innovation Partners (MSIP)MSIP is responsible for driving the real-world application and commercialization of Mount Sinai discoveries and inventions, and the development of research partnerships with industry. Our aim is to translate discoveries and inventions into health care products and services that benefit patients and society. MSIP is accountable for the full spectrum of commercialization activities required to bring Mount Sinai inventions to life. These activities include evaluating, patenting, marketing and licensing new technologies building research, collaborations and partnerships with commercial and nonprofit entities, material transfer and confidentiality, coaching innovators to advance commercially relevant translational discoveries, and actively fostering an ecosystem of entrepreneurship within the Mount Sinai research and health system communities. For more information, visitwww.ip.mountsinai.org.

About EKF DiagnosticsEKF Diagnostics is a global medical manufacturer of point-of-care (POCT) devices and tests for hemoglobin, glycated hemoglobin (HbA1c), glucose and lactate. EKF has offices in the UK, Germany, USA, Russia and China and a network of more than 200 distributors covering every country.

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Trellus Health Secures $5M Seed Funding to Transform Care for Chronic Conditions - BioSpace