Obesity And Overweight: Yoga Expert Explains Ways To Fight Obesity – NDTV Doctor

Obesity is linked with several deadly diseases. Yoga is an effective way to maintain a healthy weight. Here are some yoga asanas and diet tips that can help you fight obesity.

Obesity can increase the risk of several chronic diseases

Obesity and being overweight is not only disadvantageous but it is also a dangerous condition. It can be linked to a number of health complications like type-2 diabetes, heart disease, depression, respiratory problems, cancer and more. It also leads to liver disease, gall bladder disease, strokes and can cause complications during pregnancy. There are over 1 billion overweight adults worldwide according to a 2020 study and obesity has reached epidemic proportions globally. Studies also found that about a third of the global population-including adults and children were overweight, of which 10% of people suffered from obesity.

If you or a loved one is obese or overweight, your weight loss should be focussed more on well-being, and overall health than rapid weight loss. Rapid weight loss could be unscientific, unhealthy and cause many harmful side effects. If you want to enjoy sustained weight loss, let your aim be to lead a more wholesome, and healthy lifestyle.

Running, swimming, walking, yoga, stair climbing etc. can all be the different ways you can boost your physical fitness. Choose any activity that is suitable for your physical fitness level. It should challenge you without exhausting you. Safe and gentle exercises like yoga can help you align your body and mind to your weight management goals. Weight loss is as much as a mental workout as it is a physical task.

BMI is, an index commonly used for classification of obesity. Over weight is defined as a BMI (or body mass index) greater than or equal to 25.0 & Obesity as a BMI greater than and equal to 30.0.

Common Reasons for Obesity

Yogic techniques include practices such as Pranayama, Meditation, Yoga asanas, and Mudras. Yoga not only helps in eradicating the problem of being overweight but also helps you manage your weight safely. Yoga is a tool that focuses on holistic wellness and works better for your body in the long term.

Meditation - Beej Dhyan/Aarambh Dhyan

The mind is very much like a fertile land where we plant the seeds of our thoughts, and actions for our life. For a plant to grow beautifully, it needs its share of sunlight, fertilizer, and water. Much like a plant, how we nurture our mind and our energies will be reflected in the way that we grow. Bheej Dhyan is the meditation technique that teaches us to pause in life. We can use this method to sow the seeds that can bring about great improvement in our life. Whether we want to start a new habit, change our response, or behaviour all depends on the mind.

Bheej Dhyan or Seed Meditation tests your auto response system. Reacting to life's circumstances in an unconscious manner can either be extremely favourable or unfavourable to your growth and personal success. Seed Meditation controls and transforms this automatic response system that lies within you.

Also read: Yoga for beginners

Chakrasana can help you fight belly fatPhoto Credit: iStock

1. Include Whole Grain - Bajra, Ragi, Maize and Jowar, are some examples of whole grain that you can eat. Try switching to a vegetarian diet. Whole grains provide the body with the energy to sustain and grow and is also a major source of all essential nutrients.

2. Consume Fruits and Vegetables - Ensure that you are including 3 servings of seasonal vegetables, and 2 servings of whole fruits per day. Vegetables and fruits provide both soluble and insoluble fibre in addition to vitamins, minerals and antioxidants.

3. Eliminate Fatty Food- Stay away from Trans fats that comes in fast foods, snack food, fried foods and other processed food. Choose low fat milk, double toned and use different combinations of oil to get all essential fats.

4. Reduce your Sugar- Keep the intake of sugar to less than 10% of your total calories. If you are overweight or obese, it is recommended that less than 5% would be better for you.

5. Eat 3 balanced meals - It is important that you eat three balanced meals per day. Keep seasonal fruits aside for you to snack on.

Eat a balanced diet to maintain a healthy weightPhoto Credit: iStock

To create an obesity-free world, we need an increasing number of people to become more conscious about their health choices. This goal can be easily achieved by applying yogic techniques of Pranayama, Meditation, Yoga asanas, Mudras, and affirmations. Yoga not only helps in eradicating the problem of being overweight but also helps you manage your weight safely. This is a tool of holistic wellness and works better for your body in the long run.

Also read: Yoga for belly fat

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(Grand Master Akshar is a Yoga Master, Spiritual Guide and Lifestyle Coach)

Disclaimer: The opinions expressed within this article are the personal opinions of the author. NDTV is not responsible for the accuracy, completeness, suitability, or validity of any information on this article. All information is provided on an as-is basis. The information, facts or opinions appearing in the article do not reflect the views of NDTV and NDTV does not assume any responsibility or liability for the same.

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Obesity And Overweight: Yoga Expert Explains Ways To Fight Obesity - NDTV Doctor

Is the Vegan Movement Ready to Reckon with Racism? – Civil Eats

Earlier this year, People for the Ethical Treatment of Animals (PETA) posted a Super Bowl advertisement it said had been rejected by Fox. The one-minute clip featured cartoon animals, from bees to bald eagles, taking a knee while the national anthem hummed in the background. It closed on the hashtag #EndSpeciesism.

The media spot was an attempt, in PETAs own words, to pay homage to Colin Kaepernick and movements rejecting injustice, but for many viewers, including those of color, the comparison struck an insulting chord. Michael Harriot, a columnist for The Root, called the ad a despicable but expected example of mockery of 400 years of systemic oppression by comparing Black lives to grizzly bears and bald eagles.

PETA defines speciesism as the outdated belief that human beings are superior to all animal species. The campaignand the sentiment behind ithas offended advocates of color from the get-go. As A. Breeze Harper, author and founder of the Sistah Vegan Project, wrote in a letter to PETA in 2014, Black people will continue to be treated as animals . . . until post-racial, post-humanist, I dont see color power-holders like [PETA], practice the tenets of Black Lives Matter (along with many other anti-racist movements).

Racial conflict in the vegan movement isnt new. But this years nationwide protests against police violence and white supremacy have revived this conversation in earnest among white vegan groups, especially those that maintain a single-minded commitment to animal rights. These nonprofits, including the Humane Society of the United States, Mercy For Animals, the Humane League, and the Animal Legal Defense Fund, are largely staffed with white executives and carry out the will of largely white funders and priorities.

Some groups have stood up and spoken out for racial justice or lent their platforms to Black leaders to advocate for change, and examined the ways that their organizations reinforce white supremacy and might evolve. Others are much earlier in a process of learning, and other groups still cant see the connections between racial justice and their vegan causes.

As those groups ask themselves howand even whetherto support the movement for Black lives, their answers reveal the early stages of a glacially paced journey away from systems that have often excluded people of color at best, and denigrated their movements at worst.

In the summer of 2018, when the vegan crab cakes at Baltimores vegan soul food restaurant Land of Kush made PETAs list of the nations top 10 vegan seafood dishes, owner Naijah Wright-Brown was surprised and honored. But then, a week later, the organization put up a giant billboard of a crab on the nearby waterfront, imploring the citys residents to go vegan.

Racial conflict in the vegan movement isnt new, but this years nationwide protests against police violence and white supremacy have revived this conversation in earnest among white vegan groups.

When this gesture ignited a billboard war between PETA and a landmark Baltimore seafood restaurant, Jimmys Famous Seafood, Land of Kush found itself implicated in the debacle. Wright-Brown says PETA then wanted Land of Kush to take it a little further. She declined, but was left feeling like PETA didnt understand the challenges she faced as a Black business owner.

Land of Kush is not in that position in Baltimore to be having these types of debates, she said. Theres already a racial civil war going on out here . . . we dont want to add to it.

Wright-Brown isnt alone in this experience of alienation. In a 2018 survey that asked about burnout among animal rights activists, all the activists of color interviewed cited racism in their organization and the broader movement as a reason for their departure from the movement.

When I first got involved in the animal rights community, there were hardly any Black people . . . and never any discussions of human rights, Black vegan organizer Gwenna Hunter told Civil Eats. She came to veganism slowly, first for health reasons, and then after watching online videos about the dairy industry.

The deeper she got into the community, the more one message came through: Veganism is about the animals, because theyre voiceless. Human rights issues should not be discussed, she said. She often found herself cut off when she brought up Black Lives Matter, and thought, Its crazy that nobody wants to have these conversations.

Prominent Black celebrities from Beyonc to Venus and Serena Williams have publicly championed a vegan diet in recent years, including high-profile Black athletes Colin Kaepernick and Kyrie Irving. But its notable that while white celebrities are often vocal about their veganism for environmental or animal protection reasons, vegans of color overwhelmingly cite heatlh as the prime motivator for their change in diet. And while white vegans saturate the cultural spotlightincluding celebrities like Alicia Silverstein and Joaquin Phoenix8 percent of Black Americans identify as vegan, making them nearly three times more likely to eschew animal products than any other group of Americans.

While the vegan population is more Black than the country writ large, most vegan nonprofits with multi-million-dollar budgets cater nearly exclusively to animal-focused audiences, a practice that vegans of color have long emphasized systematically alienate communities of color. This dissonance demonstrates to LoriKim Alexander, an organizer of the Brooklyn-based Black VegFest, that anti-Blackness is wholly embedded in the system of white, mainstream veganism.

In recent weeks, educational tools explaining the role of white supremacy in mainstream veganism have been shared in progressive social media networks, as well as vegan-specific accounts. This slide deck,for example, was liked by 10,000 people, while this post from 2019 was recirculated on a radical platform and received 7,000 likes. For a few weeks following the murder of George Floyd, lists of Black chefs, educators, restaurants, and writers abounded in the vegan world.

Meanwhile, BIPOC activists have renewed longstanding calls for solidarity within the community. If vegans can have love and adoration for cows, they can love within their species, Black VegFest organizers wrote in a document that listed 7 points of Allyship for the White Vegan Community in Defense of Black Lives. If Black vegans can practice intersectionality, white vegans can, too, it read.

Mainstream, white vegan groups often weather storms of criticism without taking serious steps toward change. Alex Bury, a white vegan who has worked in fundraising at some of the largest mainstream animal rights nonprofits, including the Humane Society of the United States and PETA, says thats a typical approach. When the Movement for Black Lives and reckonings on sexual harassment have been in the news in the past, Bury says, they made some nice posts and memes, but that was it.

The modern vegan movement came to life during World War II in Birmingham, England, with the founding of the Vegan Society, which waged campaigns against cruelty to animals, particularly horses, mules, and oxen. By World War II, Western society was powered by motorized equipment, and animal advocates pivoted to focus on farms and laboratories. It was always about the animals, explains Victoria Moran, founder of Main Street Vegan and a best-selling cookbook author.

Moran has been vegan since 1983, and was mentored by a co-founder of the American Vegan Society. For decades, while white vegan culture moved into the mainstream, racism wasnt seen as relevant to the problems that vegans wanted to solve.

A lot of white people who considered ourselves liberal, and open-minded, and certainly not racistwe were kind of oblivious, Moran told Civil Eats. The idea that there was institutionalized racism that we were part of and had benefited from, we didnt know that, until the last four or five years . . . Im not proud of that, its just the facts.

Meanwhile, Black communities have used food activism to rebel against injustice since colonization. As Black VegFests Alexander put it, Our grandparents, our great grandparents, our mothers, fathers, siblingstheyve always brought [vegan traditions and food culture] to us. But whether weve been able to hear, through the white noiseliterallyis a different story.

If youre marketing specifically to white folks, youre effectively saying, Were the only ones that matter.

In the last decade, Breeze Harper, Aph and Syl Ko, Bryant Terry, and others have introduced BIPOC leadership to the vegan mainstream, teaching social justice frameworks while offering up recipes that have helped their audiences re-interpret the history of Black cuisine through a plant-based frame. Some white vegan circles have been heavily influenced by these new narratives, while others maintain that racial justice has nothing to do with ending cruelty to animals. And yet, say Black vegans, until white vegan groups approach their audiences differently, the movement will continue to alienate BIPOC members by default.

If youre marketing specifically to white folks, youre effectively saying, Were the only ones that matter, says Alexander.

In some corners of the vegan world, there are signs that meaningful change might be in the offing, even if groups arent being clear about exactly how, or when.

We are eager to become an animal rights and anti-racist organization while also being realistic that this may be a difficult shift for some, Mercy for Animals (MFA) President Leah Garcs wrote in a recent statement on anti-racism. In the statement, the group draws a connection between the impact of factory farming on animals and impact on meatpacking workers (many of whom are refugees) and communities of color that have long been impacted by meat production.

MFA is enlisting Breeze Harpers Critical Diversity Solutions to introduce third-party accountability, as well as releasing concrete goals and metrics around diversity and inclusion in the coming weeks and months. The statement uses ideas and language of allyship not found in the organizations three-year strategic plan from 2019, which alludes vaguely to diversity but does not contain the words race, racism, or white.

But change doesnt come all at once. The organizations mission statementWe exist to end the greatest cause of suffering on the planet: the exploitation of animals for foodhas yet to be revised.

We know there are areas we can do better in both messaging and programs to make our movement more inclusive and welcoming to people of color, a spokesperson at MFA told Civil Eats. We are listening to people of color within the animal movement, educating ourselves, and looking for where we can do more to foster an anti-racist culture in our movement.

Gene Baur, founder of Farm Sanctuary, has also recently recognized the overwhelming whiteness of the groups membership. [Racial justice] is an area that has been of interest to me personally, but one that has not been pursued, and frankly, that I didnt have as deep an understanding as I do now [in light of recent events], said Baur, who founded the organization in 1986. So I am learning throughout this process.

Farm Sanctuary is in the midst of a strategic planning process, and while theres nothing concrete yet in terms of commitments to offer, Bauer says the group is making progress, and he is very optimistic about the direction were going in.

Baur is proud of his communications team, which has made notable use of its platform, sharing space to encourage BIPOC leaders to advance Black Lives Matter messaging and education. Our members have been used to seeing pictures of cute animals running in the field. Which is fine, and we will continue to do that. But were going to do more than that. The way I see it is that were transforming to a new level of impact, a broader anti-oppression effort.

In response to questions from Civil Eats, PETA provided a statement saying its staff members had participated in Black Lives Matter protests and donated to the organization, and that PETA has always believed in the power of protests, pushed for equal rights, and equal consideration for all, and stood for an end to injustice.

Activists and allies all point to one obstacle as the largest barrier to reforming animal rights organizations in favor of addressing larger systems of oppression: the people who hold money and power in the animal rights fundraising community are primarily white men. These insular, mega-rich donor circles and executive teams are the primary resistors to expanding the scope of the movement.

A blog post on racial justice from the Humane League summarized the problem succinctly: Large animal protection organizations in the U.S. are predominantly white, as are their boards, major supporting foundations, and most influential donors.

The Humane League has received $17 million since February 2016 from Open Philanthropy (OP), a large-scale animal welfare funder. OP has given more than $123 million to vegan causes in that same time frame, and it almost exclusively benefits white-led, white-owned advocacy organizations, media groups, and colleges and universities.

Theres a lot of [vegan] donors out there who simply do not want to see anything about Black Lives Matter; they think it takes away from animals.

Mercy For Animals has received nearly $10 million from OP since 2016, almost $8 million has gone to Animal Equality, and $6.5 million has benefited the Good Food Institute, a cell-based meat promotion group. OPs program director, Lewis Bollard, was not available for an interview with Civil Eats, though his team shared a statement signed by other white funders committed to addressing the problem of philanthropic whiteness.

These pipelines create barriers to opening the organization to the cause of racial justice, say insiders. Theres a lot of [vegan] donors out there who simply do not want to see anything about Black Lives Matter; they think it takes away from animals, said Alex Bury.

After two years consulting independently with large animal rights donors, Bury has re-directed her energy into rectifying the white vegan movements racial shortcomings. Shes now vice president of development at Vegan Outreach, which employs grassroots activists in communities with high potential for converting new vegans (mostly college towns), and sits on the board of Womxn Funders in Animal Rights, a small group of fundraisers and philanthropists that works to funnel money to small, women-led organizations with diverse leadership teams, prioritizing projects by and for communities of color.

During the COVID-19 pandemic, this work has expanded, emphasizing direct funding of vegan, BIPOC-owned restaurants and food businesses to help them provide free meals to their communities. Organizations like A Well Fed World have raised money with similar priorities and models.

This work squares with the expressed needs of BIPOC leaders. Frustration with foundations that fund large white organizations to work in communities of color and bypassing work on the ground by and for members of those communities, a cadre of leaders from a dozen organizations published An Open Letter from BIPOC Leaders in Food & Agriculture to Food Systems Funders. The leaders decried what they saw as a pattern of paternalistic practices that entrench our marginalization, reinforce a culture of white supremacy, and devalue the knowledge and genius in our communities.

The letter included model fundraising methods and organizations, recommending that funders invest in unrestricted multi-year grants and move towards using a participatory grantmaking model with BIPOC-led orgs from and doing work in BIPOC communities.

No-strings-attached funding is a show of true allyship, as BIPOC vegan activists have made clear. As Black VegFest founder Omowale Adewale recently told Mercy For Animals, real support needs to come without any quid pro quo. His colleague at Black VegFest, organizer Nadia Muyeeb, put it his way: We are not looking for any saviors. We want allies who listen to us when we say we need resources and respect our Black spaces.

Some organizations, they fund you and then they wanna tell you exactly what to do, and thats not my mindset, said Land of Kush owner Naijha Wright-Brown, who is also a speaker on vegan issues and leader of the Black Veg Society of Maryland. Look yallweve been colonized for centuries, and nobody is going to tell me . . . how Im going to be representing my promotion of the vegan movement . . . that was a big problem.

Land of Kushwhich Wright-Brown runs with her husbandbenefitted early on from a grant from A Well-Fed World, and the partnership worked because, in her words, they wanted to support more marginalized communities and organizations led by people of color, and gave the funding and got out of the way. I love animals too, [but] we have other social issues that are equally important in our community.

Wright-Brown also feels positively about writing for Jane Velez Mitchell of the vegan media platform Jane Unchained. Shes totally for the animals, she wont deny that, Wright-Brown said of Velez Mitchell, but shes allowed me to have [conversations that center black and brown communities] without telling me how to do it.

But these types of dynamic appear to be rare. Ultimately, when white leaders refuse to include other aspects of social justice into animal rights movements, Alex Bury sees it as inherently linked to questions of ego. When white men help animals . . . the animals, will never threaten their status or power or money or jobs, says Bury. But if they help people of color or women, it could mean the white men would have to share their money and leadership positions with others. . . . That makes people in power very uncomfortable.

Aryenish Birdies consulting firm, Encompass, works primarily with animal rights groups that have an interest in hiring more people of color and engaging them in the movement. Encompass also convenes a global community of BIPOC animal rights activists called the global majority caucus, now over 100 people strong.

Birdie says her client base has quintupled since the George Floyd uprisings, but with her work with upper-level animal rights executives very much at the early stages of providing racial literacy, she estimates that real transformative progress is still about a decade away. We need to be moving towards accountability, Birdie said. There are a lot of animal groups that have a good amount to apologize for, and we should be doing that to truly make amends with communities of color if we want to talk about embracing them.

In order to fund her own work, she faces the extra obstacle of convincing powerful funders that diversity and inclusion efforts will ultimately help animals. Most of her funding comes from animal rights funders, and while she tells granters that not only is inclusivity work the right thing to do, opening the movement will also help animals eventually by building the movements power. This pitch has a difficult time competing with organizations who say theyre helping animals more directly, Birdie says.

While funders and executives are having tough conversations, rank-and-file members of the vegan movement have taken the opportunity to engage each other in conversation on racial issues, asking what race has to do with animal suffering, and what to do about it.

If everybody goes vegan, its not like theres not gonna be racism anymore, says organizer Gwenna Hunter. A month ago, Hunter started a Facebook page called Vegans for Black Lives Matter. The conversations that came out of the impromptu community have been difficult, but Hunter is encouraged. Now, to see the solidarity, Im like, This is the vegan community that I knew and loved, that I thought I was a part of.

Kyla Marie Cruz, a white vegan who runs trainings on anti-racism and white supremacy in the animal rights movement in eastern Michigan, first told Civil Eats in late June that an overwhelming amount of people interested in doing better and being better through anti-racist work and true allyship. But a few weeks later, Cruz had already seen some of the fervor is dying away for many of them.

Its going to feel hollow if organizations and individuals dont follow through.

She has also noticed that just as many are doubling down on their stance that the movement should remain singularly focused. Many of those willing to have conversations and be open to change are still unwilling to more critically examine the movement as a whole and the ways in which the existing frameworks we are operating within are, in many ways, shortsighted and harmful.

Black leaders on the ground are clear about their expectations. There are some who are trying to push the movement forward by examining what allyship actually means, reasons why theyre coming to allyship, and actually practicing what they preach, Black VegFests LoriKim Alexander said. But its [only] coming now, on the heels of thousands of thousands of deaths. It took so much pain and suffering to get to this point.

Shell believe in real change when she sees it. Its going to feel hollow if [organizations and individuals] dont follow through, she said.

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Is the Vegan Movement Ready to Reckon with Racism? - Civil Eats

Global Vegan Cheese Market Expected to Reach $2.5 Billion by 2021 – The Beet

Therising demand for plant-based foods has led to a boom in dairy-free alternatives. The global market for vegan cheese has been growing exponentially and research shows it will reach $2.5 billion before this year ends.

Transparency Market Research, a market intelligence company, published a report that predicted the overall growth of the vegan cheese market, expecting it to reach $2.5 billion before 2021, and increasing to $7 billion by the end of 2030.

It is well documented that dairy consumption can leadto manyhealth risks and potentially cause a lot of illnesses.Many people find that in their effort to be healthier, plant-based milk and butter were easy to switch to, while cheese tends to be the most difficult to give up.

With the growing cheese market, there will be a wider variety of plant-based cheeses as well as more options to choose from for personal taste preferences. The expanding variety of dairy-free alternatives will help more people to ditch dairy for good, which not only benefits consumer health but also the environment and animal welfare.

Climate change, mounting concerns related to animal cruelty, and health are some of the leading factors that are driving the vegan movement worldwide. At present, veganism is at its peak and the trend is likely to continue in the near future," thereport says.

The key players in the market contributing to this growth include fan-favorites Violife Foods, Daiya, Kite Hill, Miyoko's Creamery, Follow Your Heart, Parmela Creamery and Field Roast. Brands continue to surprise consumers with differentinnovations of nut or plant-based "cheeses" that taste just like the real thing.

For more on the best dairy-free cheeses, check out The 10 Best Dairy-Free Cheeseand The Best Dairy-Free Shredded Cheese.

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Global Vegan Cheese Market Expected to Reach $2.5 Billion by 2021 - The Beet

What You Can Learn From 20 Athletes Who Went Vegan to Get Stronger – The Beet

Now more than ever, athletes are reaching for lentils, edamame, and chickpeas instead of biting into steak dinner, to raise their strength, fitness, and overall performance levels. Here are twenty athletes who creditswitching to a vegan or plant-based diet with improving their fitness and results--through faster recovery time between workouts, quicker healing from injury, and being able tobuildleaner, strongermuscles. These superstars say that their dietshelped them get to where theyare today,such as preparing for Olympic Gold or becomingthe number one tennis player in the world.

These champion players report that eating a plant-based diet increasesenergy levels, provides more than enough clean protein to refuel and rebuild, reduces inflammation, and improves recovery time. Eating plant-based also helps them with mental clarity, andevenabates allergy symptoms like asthma during the most intense allergy season.

In the nearly one yearsinceThe Game Changerswasreleased last September and became one of the most-watched documentaries, and showed that some of the world's strongest and accomplished athletes don't need meat or dairy to succeed, more and more players are limiting their animal protein intake and are going all or mostly plant-based.

The number one tennis player in the world, Novak Djokovic, went plant-based more than twelve years ago to enhance his athletic performance and win more matches. In recent interviews, he has creditedgoing vegan with helping him rise from third place in the world to first in the world because it helped clear his allergies. Before changing his diet,Djokovic had searched for cures to the breathing issues that cost him matches and focus which caused him tostruggled during his most intense matches. The allergies used to make him feellike he couldnt breathe and would be forced to retire from competitive matches as he did in Australia.

"Eating meat was hard on my digestion and that took a lot of essential energy that I need for my focus, for recovery, for the next training session, and for the next match," he said. Djokovic emphasized he does not eat foods that require a lot of digestion, especially in the morning, when he needs all of his energy for training. Instead, he starts the day with hot water and lemon, then celery juice, and some superfood supplements.

Tia Blanco wongold at the International Surfing Association Open in 2015 andcredits her success to her vegan diet.Blanco reports thata vegan diet helps her stay strong and she enjoyseating different forms of vegan protein like nuts, seeds, beans, and legumes.

The professional surferwas influencedby her mother, who is a vegetarian andgrew up in a veggie-forward household, Blanco hasnever eaten meat in her life,which made the plant-based switch much easier. And speaking of making things easier,Blanco has an Instagram cooking page called @tiasvegankitchen where she shares her favorite simple vegan recipes so all of her fans can eat like their favorite professional vegan athlete. In addition to her home-cooked meals, Blanco recently became an ambassador for vegan company Beyond Meat and now she posts Instagram stories and highlights of her favorite meatless meat recipes.

Steph Davis has been vegan for 18 years now and says, "theres nothing in my life that hasnt become better as a result, from climbing and athletics to mental and spiritual well being." Davis has competed on some of the most challenging verticle routeson the planet likeConcepcion (5.13), which is known to be one of thehardestpure climbsanywhere. Davis holds the third overall ascent and is the first female to ever make the ascent of theroute. Davis described it as her "most technically demanding climbever."

Davis explainedwhy she went vegan eight years ago when she partnered with PETA."What can we do to start making changes in a positive way? And if it just so happens that changing our lifestyle leads to environmental benefits, health benefits, economic benefits, and positive social change, then all the better. One thing Ive learned is you dont have to do or be anything you dont want to be, and you can change anything in your life just by starting to do it. Its you who chooses who and what you are, by the things you think and the things you do."

She goes on to add,"no one says you have to become a perfect vegan overnight. But why not start making small changes and see how it feels? I believe its the small choices people make that have the biggest power to change, and nothing is more simple yet also more far-reaching than changing how and what you choose to eat. Were all here for a short time, in the end, and living a well-intentioned and compassionate life seems like what ultimately matters the most, the only real goal that I aspire to."

Tennis champion Venus Williams swearsthat making the switch to veganism was one of the factors that helped to improve her performance and get over an auto-immune disease. Thetennis star went vegan back in 2011when she was diagnosed with Sjgren's syndrome, a debilitating autoimmune disease with a range of symptoms from jointpainto swelling, numbness, burning eyes, digestive problems, andfatigue.She chose to eat plant-basedto recover to herformerly healthy self, and it worked so she stuck to it.

The seven-time Grand Slam singles champion recovers faster on a plant-based dietnow, compared to how she felt backwhen she ate animal protein. When you have an auto-immune disease you often feel extreme fatigue and random body aches and for Venus, a plant-based diet provides energy and helpsher reduce inflammation.

The Beet reported on Willaim's diet and what she normally eats in a day to stay healthy, fit, and win more matches. Talking about her favorite dinner meal, Williams adds,sometimes a girl just needs a donut!"

Mike Tyson recentlysaid he is "in the best shape ever" thanks to his vegan diet. The boxing legend then announced he's getting back into the rings after 15 years,to fightagainst Roy Jones, Jr. in Californialater this fall.

Tysonwent vegan ten years ago after dealing with health complications and in the wake of having cleaned up his life: I was so congested from all the drugs and bad cocaine, I could hardly breathe."Tyson said, I had high blood pressure, was almost dying, and had arthritis."

Now, the 53-year-old powerhouse is sober, healthy, and fit. "Turning vegan helped me eliminate all those problems in my life, and "I'm in the best shape ever." His new trainer agrees:Watching Iron Mike's speed during recent training sessions, observed: "He has the same power as a guy who is 21, 22-years old."

Oklahoma City's point guard Chris Paul decided to ditch meat and dairy and was asked join on as a co-executive producer for the popular documentary,The Game Changers.

For breakfast, Paul enjoys oatmeal with plant-based milkand nut butter. For lunch, hefuels up with pasta or brown rice with Beyond Meat sausage, grilled vegetables, and a curry sauce. His chef toldUSA Today,"The main thing is, we try to keep it as light and clean as possible for his normal routine, with organic ingredients. Anything that can minimize body inflammation. Chris is always worrying about what he can and can't eat." So far it appears he's getting it right.

In an exclusive interview with The Beet'sAwesome Vegans columnist Elysabeth Alfano, Paul said eating a plant-based diet helps him keep up with players half his age.

In 2016,Kaepernickmade the switch to veganismwith his longtime girlfriend to recover froma series of injuries that had him down for the count.The Beetrecentlyreported onhow this dietary switchhasallowedKaepernick to stay strong and healthy. Now, he's in the gym building muscle and looks fitterthan ever. But will he be picked up? The professional football player claims that a vegan diet makes him feel "always ready" to perform his best on the field.

Cam Newton just replacedTom Brady, who also follows a mostly plant-based diet, as the New England Patriot's QB, after havingmade the plant-based switch back in March 2019. The NFL Star first decided to ditch meat and dairy to recover quicker from injurieswhen he learned that a plant-based diet is proven to help reduce inflammation."I've seen such a remarkable change in the way my body responds to the food that I eat," Newton told PETA for his recent partnership for a new campaign called, "Built Like a Vegan," proving that you don't need to eat meat to be strong. Newton enjoys a meat-free burger on a pretzel bun, heavy on pickles and sauce.He adds: "People often ask, 'How do you get your protein?' I just say, 'I get it in the same way you do, but it's fresher and cleaner.' "

Newton shares how to do it: "My advice to a person who wants to become vegan is to eat on schedule. If you can eat on a schedule, you won't miss [a meal or crave meat] or think anything different, and you'll be alright."

Elijah Hall says about his vegan diet:"Going vegan was the best decision" he has ever made.Hallholds records in the indoor 200 meters and was training for the Tokyo this summer when it got postponed by a yeardue to the pandemic. Hall said "the effects that its having on my body are amazing. Becoming a plant-based athlete has opened many doors to my health and my training." We predict he'll only get faster in the next 11 months and break records, come home with golf and be the world champion in 12 months.

Five-years ago, Morgan Mitchell went vegan and it made her faster, leaner and happier. Last year she was featured in the plant-based athletes documentary The Game Changersand said,Being vegan has helped me immensely. I dont feel sluggish like I did when I was eating meat, and my recovery from training really took off. It felt like an overall cleanse for my body, and I started seeing greater results on the track.

Now Michelle is committed for the planet as well.Ultimately helping the environment and not contributing to animal cruelty was a big thing for me, too. That was my initial reason for going vegan, and the rest of the benefits were just added bonuses.

Mitchell describeswhat she eats in a day for enhanced performance and more energy to win sprints. I like to make sure I have three different types of protein in there. I use tofu, beans, and mushrooms, along with spinach, vegan cheese, and hash browns, she says. I also love to add Beyond Meat for more flavor, which is a great source of plant protein as well. That usually keeps me full for the better part of the day," she told Well + Good.

"We were taught that eating animal products was good for us but we've been lied to for hundreds of years," said Lewis Hamilton. The Beet reported on Hamiltion'svegan diet quotingThe New York Timesthat he credits his new plant-based diet with making the difference in his career. Hamilton gave up processed food and animal products for vegetables, fruit, nuts, grains, because of his strong compassion for animals, for the benefit of the environment, and his own health. Hamilton isn't the only vegan in his family. His dogRoccois fully vegan and Hamilton says he's "super happy" on Rocco's very own IG post.

Earlier this year, Hamilton gave up his private jet because he said it's a big pollutant and aims to live a sustainable lifestyle. Back in February, he started a line of sustainable clothing with Tommy Hilfiger at London Fashion Week.

Featured in The Game Changersfor his elite strength and his superhuman ability to lift a car, Patrik Baboumiam is one of the strongest men in the world and also happens to be vegan. Baboumian lifted 358 poundsin the 2009 German log lift nationals.

Back in 2014, Baboumiam partnered with PETA in his campaign "Want to be Stronger" describing powering yourself with plants and how you can build muscle without eating meat.

One of his 2019 PETA campaigns showed him posing with crossed arms and leaves in his mouths with the text:"The world's strongest animals are plant-eaters: Gorillas, buffaloes, elephants and me."

Bahoumiam's diet consists of a dairy-free shake for breakfastwith 8 grams of protein and 0 carbohydrates. For lunch, he enjoys vegan sausage, falafel, low-fat oven fires, peppers, and more grilled veggies. He normally eats 250 grams of carbs and 90 grams of protein just for lunch. Dinner includes vegetables cooked potatoes, and tofu. If you want to eat like Boubanian, he reports his food diary onhis blogBarBend.

Here's a guy who has worn many hats: Bodybuilder, Terminator, California Governor, and now vegan and advocate for the plant-based lifestyle. Arnold Schwarzenegger ditched meat and dairy and has proven that you don't need to eat animal products to be strong, healthy and reverse symptoms of heart disease. Now 73, he had a pulmonary valve replacement 1997 due to a congenitaldefectandunderwent emergency open-heartsurgery in 2018 to replacethevalve again. He thenchanged his eating and fitness habits and now extolls the virtues of plant-based eating for the environment as well as health reasons.

He is a producer of The Game Changers (a movie with many masters) and an advocate for going vegan for health, the environment and the sake of animals (he posts on IG with his pet donkey and miniature pony, both household dwelling animals).

Schwarzeneggersaid last year: "Right now, seven million people are dying every year. That is alarming and everyone in the government has the responsibility to protect the people.... 28 percent of the greenhouse gasses come from eating meat and from raising cattle, so we can do a much better job."

Jurek is an extreme ultra-marathon runner who has won the Hardrock Hundred, the Badwater Ultramarathon, the Spartathlon, and the Western States 100 Mile Endurance Run (you get the idea). Jurek has been vegan for almost two decades, after easing intoit by cutting out meat in college, heslowly stopping seafood and finally giving up all animal products once he realized that eating this way made him feel healthier and happier.

To run such an extreme amount of miles, you need to fuel your body with plant-based foods that will give you enough energy and carbohydrates to go the distance.The goal is to eat 5,000-6,000 calories of plant-based foods daily.

Jurekoutlined his plant-based diet in an interview with Bon Appetite. Instead of waking up to a hot cup of coffee to boost energy, he prefers to drink tea anda green smoothie with spirulina or chlorella and a host of other ingredients. He adds bananas, frozen pineapple slices, or mangoes, brown rice and pea protein, (for protein) to rebuild what's lost in training. This is not just any smoothie.

Soccerstar, Alex Morgan is one of the beloved members of the USA National Team that won the World Cup and has shown that the female players deserve to get equal pay as their male counterparts by the US Soccer Federation.She is also an animal rights advocate and longtime vegan, having given up meat when she decided that "it didn't feel fair to have a dog, and yet eat meat all the time, referring toher adorablepup Blue.

Morganaims to eat 90 grams of plant-based protein daily to stay fit and lean, especially for her workouts and on the field.Morgan admitted that breakfast was difficult because "a lot of the things I love like pancakes and French toast had dairy and eggs." But now she enjoys oatmeal with nut butter and berries, smoothies, rice, quinoa, veggies, black beans, protein shakes, Mediterranean food, Impossible burgers, Mexican beans, and sauteed veggie burritos, she told USA Today.

Paul Rabil who played for the Boston Cannons and the New York Lizards of Major League Lacrosse, ditched meat and dairy after his 2019 season ended and revealed he's now "officially" vegan on YouTube. "At first [switching to a plant-based diet] was to help solve some pain and trauma that I was going through. Over the last two years, I've had two herniated discs.... and that has led to a ton of shooting pain down my legs, its called sciatica," Rabil explains the purpose of his diet switch.

Headds: "I've tried to a lot of things; I've had a number of cortisone shots; I've done physical therapy for two years. And I reached a place where I was thinking 'okay maybe I can solve this with nutrition because a lot of our pain stems from inflammation.Within a few weeks, I started noticing a lot of alleviation so I started focusing and doubling down more on veganism"

Hannah Teter won Olympic gold and silver in the halfpipe and is also a seven-time XGames medalist. She changed her diet after watching the documentary,Earthlingswhen she discovered how "horrible" factory farming is. After a strict vegetarian diet, Teter liked the way she performed and believes that her diet helped her win gold at the 2006 games.

She now considers herself "plant-based" and in an interview with theHuffington Post, Teter said, "I feel stronger than Ive ever been, mentally, physically, and emotionally. My plant-based diet has opened up more doors to being an athlete. Its a whole other level that Im elevating to. I stopped eating animals about a year ago, and its a new life. I feel like a new person, a new athlete."

Djokovic is not the only tour player to go plant-based. Nick Kyrgiosshared that he does not eat meat anymore because of his strong compassion for animals.

During the time of the Australian wildfires, the Aussie native explained: "I've been passionate about animal welfare for some time now. I don't eat meat or dairy anymore. Thats not for my health, I just dont believe in eating animals."

"I tried a vegan diet a couple of years ago but with all the travel I do, it was hard to stick to it. Since then I've managed to make it work, and I've been vegetarian for quite a while.

"Seeing the footage of these animals suffering from the fires only reinforces why I've chosen this diet. When I see these terrible photos, I cant comprehend eating meat."

Matt Frazier has run 27 ultra-marathons in his career so far and continues to write about the endurance strength of being a vegan athlete in his personal blog, which he started 11 years ago: No Meat Athlete.

The Beet recently interviewed Frazier about his vegan journey and howto be a successful athlete on a plant-based diet. Whenasked about the first time he ditched meat Frazier replied, "I had already cut 90 minutes off my first marathon time. I was still 10 minutes away from the Boston Marathon qualifying time.I had plateaued, and I was not sure how I was going to find 10 minutes. [Plant-based eating] was what I was missing. Thats what it took. The other big noticeable difference to me [after going vegan] was I stopped getting injured. Injuries had always been a big part of my running journey. When I became vegan, it was around the time I ran three 50-milers and a 100-miler. I didnt have any injuries. If its done right, [plant-based diets] can really help you recover faster."

Rowing is grueling. It's known as the toughest endurance sport in the world. The world record-breaking female rower, Michaela Copenhaverwent vegan in 2012 for ethical reasons, she toldGreat Vegan Athletes.Initially, I just wanted to eat more vegetables. Those things are super good for you, and they're delicious. Beingvegetarianandveganmade me more conscious of how many servings I was getting a day (or not).

When she switched from vegetarian to vegan it was almost accidental: I was traveling for a regatta in the fall of 2012. I had been vegetarian for 1.5 years already but relied pretty heavily on dairy and eggs. While I was traveling, I was bouncing from couch to couch and had no way to safely store dairy or eggsso I decided to try a week without them. I felt great, and it wasnt nearly as scary as I thought. Ive been vegan ever since.

Now it's a value system: Once I stopped eating and using animals, I felt I could finally address a question that had been bothering me for a long timewhat right do we have to exploit other creatures? Now, I understand that we have no right, and my motivations are primarily ethical.

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What You Can Learn From 20 Athletes Who Went Vegan to Get Stronger - The Beet

The 10 Best Vegan Cheeses That Taste Like the Real Thing – The Beet

Vegan cheese has come a long way since the first time I tried soy cream cheese in the late nineties living in Los Angeles. I remember gagging at the taste andthinking there was no way that spread was going on my precious toasted bagel. Flash forward several decades and plant-based cheeses are better than ever: These days many innovative ingredients like cashews, almond milk, coconut cream, smoky flavor and fermented foods are being utilized by topchefs in the plant-based industry to create plant-based cheeses that far surpasses anything the dairy industry makes.

Dairy products areunhealthier, less environmentally friendly, and crueler to animals than plant-based alternatives.By purchasing dairy-free cheeses not only are you saving the lives of cows, but you are supporting companies that value sustainability and the environment. Below are ten delicious vegan cheeses to get you started on your love of plant-based cheese.

Chao by Field Roast, famous for its plant-based sausages, is one of the few cheese slices I can eat straight from the package. Of course, it's also great melted in a grilled cheese sandwich with a slice of tomato, in your favorite plant-based lasagna recipe, or shredded on top of a veggie pizza. This creamy cheese is coconut-based and seasoned with fermented tofu for a sweet and savory end product. Good luck eating only one slice! Chao's other flavors, Tomato Cayenne and Creamy Original are equally as delicious.

True story - I have never met a Miyoko'sCreamery cheese I didnt absolutely love. I also admire the creative founder, cookbook author, and Chef Miyoko Schinner, and her love for rescued animals and devotion to veganism. The sundried tomato garlic cheese wheel is created with cashew cream and fermented with live cultures. Serve it on grain crackers or get creative and whip up Miyokos vegan sundried tomato risotto from their website.

I need the Canada/US borders to open already so I can get some Kite Hill cream cheese since its not available in Toronto. Three people, one of whom is a talented Chef and creator of the delicious plant-based restaurant Crossroads in Los Angeles, founded Kite Hill. Their velvety smooth almond milk cream cheese is perfect on a toasted bagel with a coffee in the morning. When you need a break from spices and herbs this is one of the best plain varieties on the market.

Nuts For Cheese is a Canadian vegan company using ethically sourced and high-quality ingredients like cashews, coconut milk, and nutritional yeast. What began as one Chef in the back of a vegan kitchen has become a full-scale facility whose aim is to spread positive change through food. They have six unique cheese varieties and each one is packed with mouth-watering flavor. The Un-Brie-Lievable is a semi-firm wedge that is rich and creamy and the perfect pairing for my homemade charcuterie board. If you live in the US you can order Nuts For Cheese through Vegan Essentials.

Who doesnt have childhood memories of snacking on cheese sticks before dinner? You can now relive those moments with plant-based Cheeze Sticks by Daiya, perfect when on the go. Ingredients include coconut cream and tapioca starch but unlike their shreds and slices you dont have to melt the sticks they are delicious right out of the package (Yes, really). They are also kid-friendly and my vegan son loves them.

Your plant-based Greek salads just got a whole lot better. Violife is based in Greece so creating the Just like Feta Block was a natural fit and inspired by their Greek heritage. The tangy block goes perfectly with olives, cherry tomatoes, or a Portobello mushroom. In addition to olive extract and coconut oil, their feta contains Vitamin B12. All their delicious cheese products are vegan because they believe in living in harmony with animals and the environment.

Shake it, baby, shake it! Whip up your favorite pasta dish and sprinkle it with tasty Parmesan Grated Topping by Go Veggie for an added kick. Its totally plant-based but tastes like classic Parmesan cheese. Their website has several yummy looking recipes with ways you can use this Parmesan topping.

I did a happy dance the day I discovered Smoked Gouda Slices by Follow Your Heart.Canadians know the brand as Earth Island, but the products are the same. This hickory smoked Gouda is created with natural smoke flavor from plant sources and is the perfect ingredient for a hearty Panini sandwich with caramelized onions, roasted red peppers, and zucchini. Follow Your Heart began as a soup and sandwich counter and is now a leader in the industry with a full range of plant-based products.

No need to travel to France when you can get gourmet soft French-style cheese in over 3,000 stores across the United States. Chipotle-Serrano Pepper by Treeline is created with chipotle Marita flakes, smoky Serrano pepper, and fine cultured cashews. This vegan brand loves all animals, does not use palm oil in any of their products, and provides links to the truth about the dairy industry on its website.

You know vegan cheese has gone mainstream when grocery store giants like Whole Foods have their own line. Yup, times have definitely changed. These non-dairy Mozzarella Cheese Shreds melt and stretch for the perfect homemade veggie pizza and are also available in Cheddar.

Whats your favorite plant-based cheese? Let us know in the comments.

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The 10 Best Vegan Cheeses That Taste Like the Real Thing - The Beet

BioAge Discovers Key Pathway and Identifies Promising Phase 2 Ready Drug to Treat and Reverse Immune Aging, a Root Cause of COVID-19 Morbidity and…

BioAge Plans Phase 2 Clinical trial in Hospitalized COVID-19 Patients

Clinical development plan supported by potent inhibition of PGD2 DP1 Receptor by BGE-175, activating immune-modulating mechanisms that result in 100% survival in aged preclinical models of coronavirus

BioAges proprietary human aging data links activation of PGD2 DP1 signaling to increased risk of mortality and susceptibility to infections

RICHMOND, Calif., Aug. 25, 2020 (GLOBE NEWSWIRE) -- BioAge Labs, Inc., a biotechnology company developing medicines to treat aging and age-related diseases, today announced that it has in-licensed a clinical-stage therapy with significant promise and potential in treating immune aging in older patients hospitalized with COVID-19. The compound, BGE-175, is a potent orally administered inhibitor of the prostaglandin D2 (PGD2) DP1 signaling pathway associated with increased risk of mortality, and susceptibility to infections. The company recently generated preclinical data showing significant immune-modulating and anti-viral activity of BGE-175 which resulted in 100 percent survival in a preclinical model of the SARS 1 virus. In addition to fully protecting infected mice from death and improving morbidity, treated mice showed a 10-fold decrease in virus in their lungs. BGE-175 has demonstrated clinical activity and safety in a large number of subjects across multiple clinical trials for another indication.

Aging is the largest risk factor for COVID-19 morbidity and mortality, said Kristen Fortney, Ph.D., BioAges Chief Executive Officer. BGE-175 has the potential to restore the function of several key immune mechanisms that become dysregulated with aging, and that are critical to mount an effective response to major immune challenges such as COVID-19, SARS, and pandemic influenza. We plan to advance BGE-175 into a Phase 2 clinical trial in COVID-19 patients to evaluate whether its unique mechanism can improve patient outcomes by directly targeting immune aging.

Dr. Fortney added, Our AI-driven analysis of our proprietary human aging data maps out how the immune system is dysregulated during aging. Beyond COVID-19, BGE-175 has the potential to address other diseases driven by immune aging. BGE-175 is the second in a growing pipeline of promising therapeutics that BioAge will bring forward to treat diseases of aging.

BioAges preclinical data, obtained in collaboration with coronavirus expert Stanley Perlman, M.D., an American Academy of Microbiology fellow, and professor at the University of Iowa, shows that DP1 receptor antagonism elicits a potent protective response in a mouse model of SARS-coronavirus viral challenge.

Dr. Perlman noted, We have found over the past several years thatan age-dependent increase inDP1 signaling contributes to worse outcomes in the context of mouse infection with several human pathogens.We havepreviously shownimproved outcomes when DP1 signaling is genetically blocked, but BGE-175 is the first drug that has the same effect.BGE-175 may help counteract deleterious immune changes that occur with aging.

These preclinical data are particularly impressive and highly differentiating to support the potential of BGE-175 in COVID-19, said Adolfo Garcia-Sastre, Ph.D., Professor of Medicine and Microbiology and co-director of the Global Health & Emerging Pathogens Institute at The Icahn School of Medicine at Mount Sinai in New York City. While others in the field have used cellular models, BioAges preclinical data in a coronavirus preclinical model may offer more predictive translation of potential in clinical trials.

The pathways impacted by BGE-175 are linked to lifespan and healthspan in BioAges proprietary human aging data. The prostaglandin pathway, as well as several key components of the immune response to viral challenge, are significantly associated with longevity and multiple functional measures. Inhibition of PGD2 DP1 receptor signaling impacts multiple immune mechanisms, including activation of dendritic cells and NK cells, and reducing neutrophil infiltration. Preclinical studies demonstrate that BGE-175 inhibits neutrophil migration and that DP1 inhibition boosts dendritic cell function, both of which counteract known aspects of immune aging, and are also therapeutically promising for COVID-19 and other respiratory infections.

BGE-175 has demonstrated clear target engagement with inhibition of PGD2 signaling and safety in a large number of subjects across multiple clinical trials in another indication. Based on its groundbreaking research on the potential of BGE-175 for COVID-19, BioAge was granted a binding Letter of Intent from an undisclosed pharmaceutical company to enter into an exclusive license agreement to develop and commercialize BGE-175 for treatment and prevention of COVID-19 infections in the United States, Europe and the United Kingdom. Furthermore, for a one-year period BioAge has the exclusive option to license additional rights for other disease indications. Under the terms of the LOI, BioAge will make an upfront payment and contingent development and regulatory milestone payments plus royalties based on annual net sales. BioAge will be responsible for all development, manufacturing and commercialization of BGE-175 for treatment or prevention of COVID-19 infection in the United States, Europe and UK. Further details of the agreement will be released after additional patents applications are filed.

About the BioAge Platform The BioAge platform identifies key drug targets that will impact aging. The Companys proprietary human aging cohorts have blood samples collected up to 45 years ago, with participant -omics data that is tied to extensive medical follow-up records including detailed future healthspan, lifespan and disease outcomes. BioAge has built a systems biology and AI platform that leverages these rich datasets to identify the molecular drivers of age-related pathology. BioAges pipeline of therapies targeting these key pathways will address the significant unmet medical needs of an aging population.

About BioAgeBioAge is a biotechnology company developing proprietary drugs to treat aging and aging-related diseases. Since its founding in 2015, the Company has raised $37 million in venture capital funding from Andreessen Horowitz, Khosla Ventures, Felicis Ventures and others to back its AI-driven approach to map the molecular pathways that impact human longevity. BioAges mission is to develop a pipeline of therapeutic assets that increase healthspan and lifespan.

Source: BioAge Labs, Inc.

Contact Information:BioAge | peng@bioagelabs.comMedia | swheeler@wheelhouselsa.com

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BioAge Discovers Key Pathway and Identifies Promising Phase 2 Ready Drug to Treat and Reverse Immune Aging, a Root Cause of COVID-19 Morbidity and...

HMTC This Week: Protests create literary works and art – Hanford Sentinel

Silvia Gonzalez Scherer

"Black Lives Matter" protests and solidarity commitments worldwide have unleashed a myriad of literary works and art. As the streets fill with calls for justice, artists are expressing their own outcry using their artistic instruments. They must, for if they did not, humanity learns little from historical events.

Last year Adrian Hughes placed second at HMTCs Hanford Monologue Slam with a monologue of black experience. I thought of him when the movement began because the content of his monologue fits the stream of todays protests.

I also thought about my father-in-law who worked with Jessie Jackson in Operation Push during the 1960s. If he were alive today, he would write an essay comparing Operation Push, and the civil rights movement of back then, to todays movement for racial justice.

A societal crisis becomes fodder for artists. Artists will decipher, analyze, compare, contrast, and use their art to voice their point of view. As well, art has longevity. Especially art that describes the human condition. As the crowds fade away, the art will stay.

History books will include the current events factually and analytically. Artists will use their art to elicit emotions. Emotions from the heart and soul is often the core of art.

Kudos to those artistic institutions who have put in their programming Black projects as a response to societal pleas for action. I applaud Portland Center Stages The Community Voices Project as a new initiative to highlight Black artists at their website. They plan on exhibiting more artists routinely.

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HMTC This Week: Protests create literary works and art - Hanford Sentinel

BioMed Realty Relocates Headquarters to University Towne Centre – Yahoo Finance

BioMed Realty, a leading provider of real estate solutions to the life science community, has relocated their headquarters to discover@UTC at University Towne Centre, a campus the company has assembled and transformed over the last several years into a premier life science park in one of the top biotech markets in the country.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200825005293/en/

BioMed Realty, a leading provider of real estate solutions to the life science and technology industries, has relocated their headquarters to discover@UTC at San Diego's University Towne Centre. (Photo: Business Wire)

"Placing roots at our discover@UTC campus puts us at the center of our core San Diego market and adjacent to the regions leading life science and technology companies and research institutions," said President and CEO Tim Schoen. "This move demonstrates our commitment to continuing to invest in and serve the thriving San Diego life science community through all economic conditions, as the biotech industry and our innovative tenants advance the next generation of medicines and therapies."

Located at the intersection of Towne Centre Drive and Executive Drive, discover@UTC is a premier life science campus comprised of four buildings with 288,000 square feet. BioMed Realtys new headquarters brings the propertys leasing percentage to 94%. Other tenants that also moved their corporate headquarters to discover@UTC include Poseida Therapeutics, Samumed, and Human Longevity.

BioMed Realty acquired the campus in phases in 2010 and 2016, and successfully remodeled and repositioned the entire campus in 2017 under Blackstones ownership. In 2020, BioMed Realty completed significant improvements, including converting the properties to state-of-the-art lab/office buildings, enhancing the exterior faade, and adding new interior and exterior amenities.

To support the community of life science companies occupying discover@UTC, the property provides a host of amenities designed to enhance collaboration, support wellness, and provide convenience for tenants, including an on-site fitness center and caf, subterranean and surface level parking, and on-site security. In addition to this, the property contains a newly designed, eco-friendly parklike setting with tranquil water features, outdoor meeting spaces and a recreation/athletic field. The campus provides ideal ingress and egress access points to both the I-5 and I-805 freeways, and is centrally located within walking distance of the newly renovated Westfield Mall and a number of nearby retail stores, high end restaurants, fitness centers and hotels.

About BioMed Realty

Founded in 2004, and a Blackstone portfolio company since 2016, BioMed Realty owns, operates and develops high-quality life science real estate comprising 13.6 million square feet, including 2.5 million square feet of Class A properties in active development, to meet the growing demand of the life science and technology industries. BioMed Realtys portfolio is located in the leading innovation markets throughout the United States and United Kingdom, led by Boston-Cambridge, San Francisco, San Diego, Seattle, New York and Cambridge, U.K. With over 200 tenant partners, BioMed Realty provides real estate solutions for global enterprises, established biotechnology and innovation companies, leading universities and premier research institutions. Follow us on Twitter @biomedrealty.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200825005293/en/

Contacts

Hamilton McCullohAllison + Partners on behalf of BioMed Realty206-910-9797hamilton.mcculloh@allisonpr.com

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BioMed Realty Relocates Headquarters to University Towne Centre - Yahoo Finance

Find Out Updated Report On Precision Medicine Software Market Along With COVID-19 Updates, Ongoing Trend, Scope, CAGR, Forecast Till 2027 And Top Key…

Global Precision Medicine Software Market analysis 2020 covers the entire supply chain, focusing on supply, demand, trade and prices by country and product. Precision Medicine Software market is expected to keep experiencing a greater level of competition with a growing number of players focusing on securing a larger market share. It incorporates thorough business profiles of some of the prime vendors in the market. The report includes vast data relating to the recent discovery and technological expansions perceived in the market, wide-ranging with an examination of the impact of these intrusions on the markets future development.

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Under the COVID-19 outbreak globally, this report includes a detailed and comprehensive overview of the competitive landscape and the administrative structure of the Global Precision Medicine Software Market. In this way, users gain an adequate understanding of the condition of drivers, restrictions, opportunities and strategies that affect the market. The report also includes both subjective and objective analyzes of the global market.

Companies considered and profiled in this market study: Syapse Inc. (US), 2bPrecise LLC (Israel), Foundation Medicine Inc. (US), Fabric Genomics (US), SOPHiA GENETICS SA (Switzerland), PierianDx Inc. (US), N-of-One Inc. (US), Human Longevity Inc. (US), Translational Software Inc. (US), Sunquest Information Systems Inc. (US), Gene42 Inc. (Canada), LifeOmic Health LLC (US), NantHealth Inc. (US), Tempus Labs Inc. (US), Flatiron Health Inc. (US), IBM Watson Group (US), and Koninklijke Philips N.V. (Netherlands) etc.,

North America, Europe, the Asia Pacific region, the Middle East and Africa as well as Latin America are the most important regional markets. However, it is now also to be expected that some other regions will take the lead in the next few years and prove to be the most promising regional markets. The global Precision Medicine Software Market is also expected to grow rapidly in the near future due to the presence of a large number of people entering this market sector.

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Thus, a complete study of the competitive landscape of the Global Precision Medicine Software Market has been given, presenting insights into the company profiles, financial status, recent developments, mergers and acquisitions, and the SWOT analysis. This study also provides an in-depth analysis of the global market with future estimates to identify current trends and investment trends for the forecast year 2020-2027.

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At IT Intelligence Markets, we model all our work on our core philosophy that believes in customer satisfaction. We serve a global clientele by supplying market intelligence research reports after conducting exhaustive research. Our reports are replete with productive insights & recent market dynamics as the healthcare industry is constantly undergoing changes like ever-changing consumer preferences, supply channels and latest technologies. Our market research analysts not only investigate the market for drivers, restraints & challenges but also gauge the overall progress of the market by comparing chief market players.

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Find Out Updated Report On Precision Medicine Software Market Along With COVID-19 Updates, Ongoing Trend, Scope, CAGR, Forecast Till 2027 And Top Key...

Hulk’s Transformation Isn’t Over, According to MCU Fans – Showbiz Cheat Sheet

The Hulk is one of the most popular superheroes in the world, and hes been around for a long time.

As a result of this longevity, the Marvel Cinematic Universes Hulk has gone through many transformations throughout his years on screen. For example, Bruce Banner used to be played by Edward Norton, and now hes played by Mark Ruffalo. The Hulks changes have been more than skin deep, too, as Banner has been slowly learning about how to control the Hulk.

That said, in the comics, the Hulk changes even more, and some Marvel fans are convinced that in the movies, hell become similar to his comic book counterpart.

The Hulk has always been a classic case of Jekyll and Hyde, where Banner is just a regular guy but hell turn into the Hulk whenever hes angry. In the beginning of Banners story, hes just trying to figure out why this is happening to him.

However, by the time that he shows up in the first Avengers movie, Banner revealed to the team that he can transform into the Hulk whenever he wants, since hes always angry.

Banner continues to gain more control of the Hulk as the Marvel movies progress. InAge of Ultron, Scarlett Johanssons Black Widow says a lullaby that calms him down and allows him to transform back into his human form.

In the most recent Marvel movies, Banner has complete control of the Hulk, and hes able to be a regular person while in his Hulk form.

As a result, some Marvel fans on Reddit think that the Hulk has done transforming in the movies. By becoming Professor Hulk, as hes called, Banner has been able to completely control that side of him.

This would seem to be the natural end to the Hulks story, since controlling the Hulk was always the thing that Banner has strived for.

Like one fan said, Professor Hulk is the endpoint of Ruffalo. Other fans agreed, and one fan said, I think theyll drop the character for awhile.

Some fans speculate that Marvel is introducing She-Hulk on her Disney+ show as a way of passing the torch between the Hulk and She-Hulk.

That said, some fans disagree with this idea.Endgame was the endgame for many Marvel characters. Iron Man and Black Widow both died inEndgame, and Captain America retired and passed his shield off to the Falcon. Fans think that if Marvel was done with the Hulk, Marvel wouldve ended his story atEndgametoo, but Marvel didnt.

RELATED: Mark Ruffalo Deserves to Star in a Stand-Alone MCU Hulk Movie

In the comics, the Hulk is able to absorb radiation to become stronger. This has led to some interesting stories, and they could potentially be where the Marvel movies will take the character.

For example, many fans on Reddit think that the Hulk will eventually transform into Worldbreaker Hulk. Worldbreaker Hulk is one of the most powerful characters in Marvel history, and, like his name implies, hes so strong that he can destroy entire planets.

The Marvel movies has somewhat hinted at adapting this storyline, but Marvel came short of actually adapting Worldbreaker Hulk.

And then theres Maestro, which is another possible direction that Marvel can take the Hulk. In the comics, the Hulk absorbs so much radiation that he becomes Maestro. Hes still as strong and as tough as the Hulk is, but Maestro gained new powers after his transformation, and they include a few psychic abilities.

These were the two most popular theories, but there are more options. Either way, many Marvel fans are still hopeful that Ruffalos Hulk will show up again in the MCU.

Read more here:
Hulk's Transformation Isn't Over, According to MCU Fans - Showbiz Cheat Sheet

Remembering the Work of GN Ramachandran and Others in the Time of COVID-19 – The Wire Science

G.N. Ramachandran. Photo: Current Science, vol. 80, no. 8, April 2001/fair use.

The whole world is reeling under the impact of the COVID-19 pandemic. The safest way out depends on manufacturing an effective vaccine. Many vaccine candidates are currently in different stages of clinical trials. A quick scan of the list suggests over half the candidates are attempting to use the novel coronaviruss spike protein to generate immunity, so getting its structure right is critical.

G.N. Ramachandrans work from the 1960s is notable in this regard. I was first introduced to his influence on structural biology as a graduate student and have always wished he were better known outside this niche field. His work has guided the design of protein-based vaccines and therapeutics touching everyday life. However, his isnt a household name even in India.

Ramachandran began his academic career as a student of electrical engineering at the Indian Institute of Science, Bengaluru. He was soon pulled into the physics department by C.V. Raman, who said, I am admitting Ramachandran into my department as he is a bit too bright to be in yours.

Under Raman, Ramachandran began research into the field of optics and X-ray topography. After graduation, he earned a PhD at the University of Cambridge, in the laboratory of Lawrence Bragg. He focused on X-ray crystallography, a technique used to analyse the structures of proteins.

Around the same time, the American physicist Linus Pauling was conducting groundbreaking work on the nature and structure of proteins. Paulings teaching and writings had a great influence on Ramachandran. So when the latter became a professor of physics at the University of Madras in 1952, he set up an X-ray crystallography laboratory to study biological structures.

Proteins are made of long-chain polymers called polypeptides. There can be one or multiple polypeptide chains that come together to form a protein. The novel coronaviruss spike protein comprises three identical peptide chains. Each chain consists of repeating units called amino acids. The chain folds into intricate shapes or motifs, such as helices and sheets. These shapes are significant; misfolded proteins often give rise to debilitating diseases.

The long orange region in the spike protein is the alpha helix and the pink region is a beta sheet. Mixing and matching of motifs form different protein structures required to ensure the protein performs its function. In this case, the spike proteins overall structure helps to bind with a protein on the surface of cells in the human nose and mouth.

The order of amino acids within a peptide chain dictates how it will fold. Amino acids take their name from the nitrogen-containing molecule (amino) on one end and the carbonyl group (acid) on the other, with a connecting carbon atom in the middle (C). The differences between amino acids come from a third part, called the side chain (R), which attaches to the central carbon atom.

In the mid-20th century, the idea of firing beams of X-rays at molecules to elucidate their structure based on how they diffracted the beams was new. In 1951, Pauling, Robert Corey and Herman Branson published their descriptions of the alpha helix and beta sheet motifs. Ramachandran wanted to continue this work, and chose to study the structure of collagen first.

Collagen is protein found abundantly in the human body: it makes up the bulk of our skin, cartilage and connective tissues. Together with his postdoctoral fellow, Gopinath Kartha, Ramachandran proposed a triple helix structure for collagen also called the Madras helix. However, Alexander Rich and Francis Crick contested this idea because they thought this structure allowed little space between atoms than was compatible with the prevailing understanding of chemistry.

This set Ramachandran and his colleagues C. Ramakrishnan and V. Sasisekharan on the path to further understand and describe the structures of polypeptide chains. They conducted a survey of the crystal structures available to determine how close two atoms could approach, and thus deduce the permissible interatomic distances within a polypeptide chain.

They also found that in a chain, each amino acid can only rotate around two bonds. Based on this they characterised two angles phi (), the angle between the nitrogen atom and the central carbon atom, and psi (), the angle between the carbonyl carbon atom and the central carbon. The figure below shows the two angles.

Now, they could plot all possible combinations of these angles within a given polypeptide sequence against each other, and eliminate any combination that violated the interatomic contact limits. And voila! They managed to reduce a messy biological problem to simple considerations in elementary mathematics.

The resulting Ramachandran plot changed how biochemists studied molecules of interest and unraveled complicated biological processes. Its a plot with phi on one axis and psi on the other. At a glance, the graph revealed islands of possible combinations separated by seas of impossible structures. If a molecules angles pulled it into the sea, biochemists would know it couldnt exist in the body and follow the laws of physical chemistry at the same time.

More broadly, biochemists today can quickly understand which structures are possible and which arent, and compare known and unknown structures in an intuitive manner. The Ramachandran plot has also become an elegant way to introduce students to protein structural biology and help them understand how structure and function are related to each other.

When Ramachandran died in 2001, at the age of 78, the tributes flooded in. One in particular, by Janet Thornton, published in an obituary by Easwara Subramanian, went thus:

I have never met Professor Ramachandran, but his contribution ranks with Paulings discovery of the -helix. It never fails to excite me, when I see the Ramachandran plot and realise how much of the beauty and order of protein structures is encapsulated by this plot. I also think that this major discovery highlights the importance of clear thought and vision that do not always need expensive equipment and huge teams of people.

The plots remarkable longevity is unsurprising given its endless significance in protein structural biology. It is vital that researchers independently validate different biological structures so that others who use those biological objects, like proteins, to develop drugs and vaccines can be sure they know the structure well enough. There exist a variety of algorithms that can check a structures accuracy using updated Ramachandran plots.

When they need to check the structure of an unknown protein, researchers compare data obtained from crystallographic studies and from theoretical calculations. The more the plots match, the more confident scientists can be that their structure is the right one.

Ramachandrans life is a testament to the power of curiosity, intellect and determination. Science education can be biased in favour of assigning credit to individuals, often white men of the West, over groups. In fact, science is an inherently collaborative endeavour, with each generation building on the work of previous ones. So just as we celebrate Ramachandrans life and work, lets also celebrate the lives and work of his students and collaborators who together helped advance the science of protein structural biology such that it has risen to the occasion in our present crisis as well.

Deepika Calidas is a biochemist. Her last position was as a postdoctoral fellow at the Johns Hopkins School of Medicine.

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Remembering the Work of GN Ramachandran and Others in the Time of COVID-19 - The Wire Science

How Gavin Williamson failed latest A-level test and lost all remaining trust Tom Richmond – Yorkshire Post

NewsOpinionColumnistsBORIS Johnson sacked the top official at the Department for Education this week, saying it was time for fresh official leadership.

Saturday, 29th August 2020, 8:30 am

Jonathan Slaters departure came shortly after Ofqual chief executive Sally Collier resigned over the A-level and GCSE exams debacle.

I hope both will still give evidence to next weeks Education Select Committee inquiry into the awarding of grades and to quote the Prime Minister that mutant algorithm.

Its also vital that teachers and students know where they stand before the new academic year begins how much of the curriculum will be feasible and how will their work be assessed?

This much was clear after Williamsons latest interview on Radio Fours Today programme I, and others, now struggle to trust a single word that he utters.

It began with the latest U-turn this time on the wearing of face masks in schools. At every stage we always listen to the best scientific and medical advice, he said.

Williamson then ignored a question about the views of Dr Jenny Harries, the deputy chief medical officer, who had said 48 hours previously that evidence about the need for over-12s to wear face masks was not strong.

Told that headteachers were dizzy from the frequency of Government U-turns, the Minister said: We set out really clear guidance in early July. If it was that clear, why the confusion now?

Williamson was no clearer when responding to a senior Tory MPs call for the firm smack of government to spread the message that schools are safe. That is why we have been absolutely clear... whittered Williamson. If you had been, backbenchers would not be mutinous.

Told it had been a torrid time, he was then asked if he expected to still be in his job in a years time. Not only did Williamson dodge the question I love the job, I have one of the very, very best jobs in government but there was no apology for the angst that he has caused.

It was then put to Williamson that an awful lot of his own MPs do not share his confidence. He responded by talking about educations amazing ability to transform lives and his upbringing in, Im ashamed to say, Yorkshire.

Finally, Williamson was asked about Ofquals algorithm and whether he had pressed the exam regulator to see if it would adversely affect poorer children. At every stage... fairness had to be at the heart of it, he obfuscated.

The presenter persisted did the Minister ask how the model would affect poorer children? He said that he did so. Yet, when pressed to see if he was satisfied by any assurances given, he started talking about the difficulties in Scotland, Wales and Northern Ireland over exams.

Having then intimated that Ofqual, and not the DfE was to blame, Williamson was then asked why he had not sought resignations earlier? His unease was again discernible.

And when the issue of an independent inquiry was raised at the end, to ensure children are not treated again like this, Williamson said other measures were being considered.

Evasive, insincere and disingenuous, a student would expect a Grade U if they performed in an exam and failed to answer so many basic and fundamental questions.

Why, therefore, should we continue to trust Gavin Williamson with the education of the next generation when his primary preoccupation appears to be saving his own job at whatever cost? I despair.

GAVIN Wiliamsons political disasters do for now take the heat off Matt Hancock, the Health and Social Care Secretary. Those two words for now are key and pertain to social care and staff shortages in this sector.

Yet some interesting feedback from an acquaintance whose daughter, who is studying medicine, has been working in a care home during Covid. They commented on what a positive experience it has been. They also saw how the most basic of personal care is critical to good medicine.

And, because she got to know the patients better than she would on a temporary ward, she has seen them more as human beings who need special care and attention. Now appreciative that basic care is as important as sophisticated medical interventions, theyre valid points that Ministers should take on board.

IMITATION, they say, is still the sincerest form of flattery hence why I spotted Tony Blairs autobiography in a prominent position on the bookshelf of Damian Hinds when the former Education Secretary was interviewed by Channel Four News.

What I do know, however, is that schools policy should not be a political football; there should be far more cross-party co-operation, but I fear this is a forlorn hope when Parliament is so polarised.

TALKING of Tony Blair, he was still Prime Minister when Jimmy Anderson took the first of his 600 Test wickets.

A measure of Andersons longevity, the Education Secretary back in May 2003 was Charles Clarke he had replaced Estelle Morris after she resigned because she believed she was not up to the job.

A rare honourable resignation take note Gavin Williamson there have been significantly more Education Secretaries than England cricket captains in the past 17 years. On that, Im stumped.

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How Gavin Williamson failed latest A-level test and lost all remaining trust Tom Richmond - Yorkshire Post

Equipping the Immune System to Fight Against COVID-19 – BioSpace

The coronavirus that causes COVID-19 has one major advantage over us it is a new human virus. Most people have not encountered the virus before, meaning their immune system is not primed and ready to fight it. When someone gets sick with COVID-19, there is a lag in an efficient immune response, giving the virus time to do significant damage before the immune system can reign in the infection.

It essentially becomes a race between how fast your immune system can clear the virus and how quickly the virus can replicate and induce damage, Agustin Melian, MD, Chief Medical Officer and Head of Global Medical Sciences at AlloVir, told BioSpace.

To develop an effective treatment or vaccine for COVID-19, scientists must understand how the immune system is impacted during the disease. One type of immune cell that is particularly important in the bodys response to COVID-19 is T-cells. T-cells perform many functions, including recognizing invading viruses such as the coronavirus that causes COVID-19.

Multiple studies from Wuhan, China reported that COVID-19 patients had very low T-cell counts; the sicker the patient, the lower their T-cell count. Lower T-cell counts were correlated with poorer outcomes (including higher risk of death) and T-cells isolated from COVID-19 patients also showed signs of exhaustion.

The elderly, patients with low T-cell numbers, and patients who express exhaustion markers on their T-cells are high risk groups in which nave cell responses (responses against a virus they have never seen before) may be deficient or delayed, thus allowing the virus to induce a large amount of damage, Dr. Melian explained. These patients may, therefore, benefit from AlloVirs approach which is designed to restore natural T-cell immunity in high risk patients.

Could giving high-risk COVID-19 patients functional T-cells against the coronavirus boost their immune system and help them recover? This is the question AlloVir aims to answer.

AlloVir creates allogeneic (off-the-shelf) virus-specific T-cells designed to treat common and devastating viral-associated diseases in vulnerable patients, such as those who are immunocompromised or patients who received an organ or stem cell transplant. Now, they are expanding their anti-viral T-cell arsenal and taking aim at COVID-19.

We believe AlloVirs technology is well positioned to treat patients with COVID-19 because our technology is designed to provide SARS-CoV-2 specific T-cell immunity while leaving non-infected cells intact, Dr. Melian commented. Our virus-specific T-cell candidates have been used to treat more than 275 immunocompromised patients with life-threatening viral infections and diseases and we believe it our approach may also have promise in treating COVID-19.

Fighting viruses with T-cells in immunocompromised patients

When you get infected with a virus, your immune system responds to the foreign threat by making specific T-cells that can recognize the virus. These specific T-cells prompt your immune system to destroy any cells infected by the virus.

However, if you have a T-cell deficiency, your immune system cannot robustly protect you. This is a major problem because an otherwise innocuous virus can become a serious infection, causing complications, and possibly even be life-threatening.

That is where AlloVir comes in. They address the underlying problem the weakened immune system. A weakened immune system can be beefed up by giving patients with T-cell deficiencies off-the-shelf virus-specific T-cells (VSTs) originally taken from healthy people. This restores their natural T-cell immunity and helps their immune system fight off the viruses.

At AlloVir, we are a leading innovator in discovering and developing allogeneic, virus-specific T-cell immunotherapies, Dr. Melian said. We are now excited to be applying our capabilities in discovering and developing SARS-CoV-2 specific T-cells to join the fight in developing a COVID-19 program for patients at high risk of severe and devastating disease.

AlloVirs virus-specific T-cell platform

To create AlloVirs T-cell therapies, the target virus is first studied carefully to identify its specific antigens (unique molecules on the outside of each virus that are specific to the virus and alert the immune system). The best antigens those that induce a strong T-cell response are used to create the therapy.

Next, blood is taken from healthy donors who have been exposed to the virus of interest and T-cells are isolated from the blood. The T-cells are activated in the lab they are trained to recognize the identified viral antigens, enabling the T-cells to selectively recognize only the desired virus.

After the T-cells have learned to recognize the specific virus, they are expanded to generate multitudes of cells. Once the activated, specific T-cells are created, they can be cryopreserved and kept for a long time, making them readily available as soon as a patient needs them. The entire process, from antigen selection to donor to ready-to-go T-cell treatment, can be completed in a matter of weeks. This process can be seen in the visual below.

Source: AlloVir

Patients are matched using the companys proprietary human leukocyte antigen (HLA)-matching formula. HLAs are proteins on the surface of cells that regulate the immune system.

Our proprietary donor selection algorithm, known as Cytokin enables us to cover >95 percent of patients in our target population from cells derived from a small number of donors, Dr. Melian said. This proprietary process of prospectively manufacturing cells for off-the-shelf use enables us to study our allogeneic cell therapies in large numbers of patients that suffer from global health crises, like seasonal influenza and, as we are discussing, the COVID-19 pandemic.

These T-cells are advantageous because they are active against a single virus or multiple viruses, are not patient-specific (so they are readily available) and are a single treatment that provides lasting protection. The biggest bonus is the immediate off-the-shelf use for time-sensitive infections in vulnerable populations, added Dr. Melian.

In addition to developing their COVID-19 therapy (called ALVR109), AlloVir has two other multi-virus specific T-cell therapies in development: Viralym-M (ALVR105) and ALVR106. Both therapies focus on treating viral diseases common to stem cell and solid organ transplant patients and other vulnerable populations.

Viralym-M targets six common viruses: BK virus (BKV), cytomegalovirus (CMV), adenovirus (AdV), Epstein-Barr virus (EBV, also called human herpesvirus 4), human herpesvirus 6, and JC virus (also called human polyomavirus 2). Although these viruses are widespread and infect most people, they only cause severe problems in people with weakened immune systems due to age, organ or stem cell transplant, or disease (such as diabetes or AIDS). In a Phase 2 study, 93 percent of 38 allogeneic stem cell transplant patients had a clinical response to Viralym-M treatment and functional Viralym-M cells lasted up to 12 weeks in the patients.

ALVR106 targets four common respiratory viruses: influenza, parainfluenza virus, respiratory syncytial virus (RSV), and human meta-pneumovirus (HMPV). While these viruses tend to cause mild to moderate respiratory illnesses, they can cause severe, life-threatening illness, especially in people with weakened immune systems. ALVR106 is still in preclinical development but clinical trials are expected to begin this year. Overall, AlloVir expects to have three new proof-of-concept (POC) Phase 1b/2 and three pivotal Phase 3 studies started over the next 6-18 months.

Off-the-shelf T-cells against COVID-19

While AlloVir originally designed their T-cell therapies for transplant patients, their platform can potentially be applied to any virus to create virus-specific T-cells. This versatility allowed AlloVir to pivot and create T-cells against SARS-CoV-2, the virus that causes COVID-19. This new investigational therapy, called ALVR109, is being developed as a stand-alone treatment, though it may also be incorporated into their ALVR106 respiratory virus therapy at some point in the future.

Normally, the body would make virus-specific T-cells on their own and these would clear the virus, commented Dr. Melian. We enable that process in patients who otherwise would be T-cell deficient to restore T-cell immunity by giving ex vivo expanded cells that come from patients who already have demonstrated a potent immune response and have cleared the infection.

The process of creating coronavirus-specific T-cells is the same as creating their other virus-specific T-cell therapies. First, blood is taken from people who have recovered from COVID-19 and the T-cells are isolated. Then, the cells are stimulated with viral antigens in the lab, expanded, and cryopreserved.

We purposely choose a broad range of viral antigens to stimulate the T-cells to ensure the virus cant circumvent the virus-specific T-cell therapy by mutating or developing resistance, Dr. Melian said. Working with a wide spectrum of viral activity is different than other approaches that just focus on one viral antigen.

An open-label Phase 1 trial (called BAT IT) is anticipated to start within the next few months. Initial clinical studies of ALVR109 aim to treat high-risk COVID-19 patients, such as the elderly, to prevent organ damage. Prophylaxis studies, where the T-cells could be given to high-risk or immunocompromised patients who are not currently sick with COVID-19, may be considered later.

Coronavirus-specific T-cells vs. COVID-19 convalescent plasma

You may be wondering if another treatment that uses blood from COVID-19 survivors, called convalescent plasma therapy, is similar to AlloVirs T-cell therapy. In convalescent plasma treatment, antibodies from COVID-19 survivors are isolated from their blood by separating out their plasma (the liquid part of the blood). The plasma is given to COVID-19 patients to help their immune system fight off the infection.

Although convalescent plasma and AlloVirs coronavirus-specific T-cell treatments are both derived from COVID-19 survivors blood, the two treatments are fundamentally different.

Antibodies and T-cells work in different areas of the immune system, explained Dr. Melian. Antibodies can go after viruses in circulating blood but cant necessarily see viruses in infected cells. On the other hand, T-cells are pleotropic and directly attack virally infected cells, turning off the viral factories. T-cells are interesting because it is a live therapy they can home to virally-infected cells and direct the immune system.

Dr. Melian went on to explain that T-cell approach may be more comprehensive because they can support other immune cells that work against viruses, such as B-cells that make viral-specific antibodies. T-cells can also stimulate cytokines including interferon (a group of signaling proteins the immune system uses to respond to viruses), which further activates the bodys antiviral response.

Providing virus-specific antibodies may be beneficial and protective for some viral infections, Dr. Melian added. We dont know how these antibodies affect COVID-19 patients yet, but COVID-19 has a high mortality rate despite standard of care treatment. In this respect, it is important that all viable approaches to treatment be evaluated and I am very pleased to see these therapies have entered clinical testing.

Convalescent plasma and AlloVirs coronavirus-specific T-cell therapies are not mutually exclusive, so they could even be used together.

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Equipping the Immune System to Fight Against COVID-19 - BioSpace

Our Son Wanted to Be Vegetarian, and We’re Proud He Stood Up For What He Believes In – Yahoo Lifestyle

Child is eating vegetables. He is very happy.

I'll never forget the day my son became a vegetarian. He had just finished first grade and celebrated his seventh birthday, and he didn't even know what the word meant. It was Monday, and I - in the time-honored tradition of parents everywhere - had made one of the 10 or so dishes I knew my child would eat: lemon pepper chicken with broccoli and rice. "This is chicken, right? Like the animal?" my son asked. "Yes. It's chicken like the animal." My suspicion was already rising. He had just read Charlotte's Web, and the discussion of what a smokehouse meant to Wilbur had caused some angst. My husband and I exchanged a glance across the table. What now, the look said. He put down his fork. "I don't want to eat it. I love animals. Why would I eat them?"

"Just eat your chicken. You can be a vegetarian tomorrow." I hadn't planned on a dinner fight. We had kissed those days goodbye years ago. "What's a vegetarian?" he asked. I explained: someone who doesn't eat meat. "I want to be a vegetarian," he declared. My husband tried as well. "This is what's for dinner. Tomorrow we'll make something else."

The fork remained down, and I could tell my son was struggling. His face looked tragic, near tears. He generally does what we ask without complaint, and I could see the conflict in him: listen to Mom and Dad or stand up for his beliefs - something Mom and Dad had also told him to do. That look told me everything . . . and broke my heart.

Related: Want to Talk to Your Kids About Their Weight? We Asked an Expert For Tips

With one more silent conversation with my husband, a parenting survival skill I hadn't known about before having my own kid, we gave in. "OK," I sighed. "But if you are going to be a vegetarian, you have to eat vegetables, not just, like, macaroni and cheese." My son happily agreed and proved his commitment by finishing all of his broccoli and rice.

Now, three years later, we've become experts on vegetarian meals - cooking them, ordering them, making them delicious. I've also become an expert on fielding the usual questions or comments. "Aren't you worried about protein?" "It's just a phase." "What do you even eat?" "I hate tofu."

Story continues

Here's the thing: I also hated tofu three years ago before I learned to cook it. And yes, we do eat tofu, and seitan and beans and pasta and vegetables and mushrooms and a host of other foods you might find you like as much as or more than chicken, pork, and beef. It does help that I am a culinary professional, and as soon as I accepted the new way of life, I found it fun to learn to cook vegetarian meals and, increasingly, vegan. And no, it wasn't a phase. Or if it is, it's been long enough that it has become an era in our lives that has enriched our eating habits.

But it's the protein question that gets me. It's my least favorite question, partly because people often don't really want an answer (they want to imply something) and partly because it's the obvious question, one we asked right away. I became something of a protein pro in the early days of our vegetarianism. In addition to researching nutrition intake needs for children the old-fashioned way, I reached out to a friend who happens to be a registered dietitian. The summary of what she said is this: As a country, we are overly obsessed with protein. If he is eating enough food, he is almost definitely getting enough protein. But we have to watch out for his iron intake now. Luckily, he likes spinach, and I can add it into most dishes. We also switched his vitamins to the kind with extra iron.

Related: Wondering If It's OK to Raise Your Kid Vegetarian? We Asked the Experts For Advice

Now when someone asks me about his protein intake, I answer with the question, "I have a lot of information about this. Do you want to hear it?" Usually they give me some kind of no. Sometimes they just keep suggesting vegetarian foods that have protein as though I am a recording secretary with a notepad at the ready.

The 10 or so recipes we have in our rotation now are a little different, but not much. We eat tacos still, but we use seitan and spinach as the filling. Our lasagna is a pesto spinach concoction we all love so much that we never have any leftovers. And the lemon pepper chicken has become lemon pepper tofu with broccoli and green peppers (for iron), which I do enjoy now that I learned to cook that product properly in self-defense.

I've even started teaching plant-forward cooking classes in addition to my work as a bakery chef, so my son's choices have been good for my career as well as our health and the planet.

Most importantly to us, my son has learned that he can stand up for what he thinks is right. He ignores the teasing he sometimes gets from friends (and not-friends), he donates time and sometimes money to animal-rights causes, he is maybe the only 10-year-old with subscriptions to Catster and Dogster, and - the thing I am most glad of - he stood up to authority figures who wanted him to do something that made him uncomfortable. I am so proud of him for disobeying his parents that day.

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Our Son Wanted to Be Vegetarian, and We're Proud He Stood Up For What He Believes In - Yahoo Lifestyle

CS Lewis and Critical Reactions to Transhumanism – Discovery Institute

Image: Screen shot from That Hideous Strength: C.S. Lewis's Prophetic Warning against the Abuse of Science.

Editors note: Published on August 16, 1945,C. S. LewissThat Hideous Strengthis a dystopian novel that eerily reflects the realities of 2020, putting into a memorable fictional form ideas expressed in Lewiss non-fiction work, The Abolition of Man. To mark the former books three-quarter century anniversary,Evolution Newspresents a series of essays, reflections, and videos about its themes and legacy.

James A. Herrick is the Guy Vander Jagt Professor of Communication at Hope College in Holland, MI. His books include The Making of the New Spirituality: The Eclipse of the Western Religious Tradition.

This post is adapted from Chapter 10 ofThe Magicians Twin: C. S. Lewis on Science, Scientism, and Society, edited by John G. West. See also,

Not surprisingly, contemporary Transhumanism has attracted a number of informed critics. I will briefly review two prominent voices in the opposition camp who reflect concerns at the heart of C. S. Lewiss own case. Hava Tirosh-Samuelson, a skeptic as regards the Transhumanist vision, echoes one of the central arguments of The Abolition of Man biotechnology now threatens to exercise control of nature itself:

Due to genetic engineering, humans are now able not only to redesign themselves but also to redesign future generations, thereby affecting the evolutionary process itself. As a result, a new posthuman phase in the evolution of the human species will emerge, in which humans will live longer, will possess new physical and cognitive abilities, and will be liberated from suffering and pain due to aging and diseases. In the posthuman age, humans will no longer be controlled by nature; instead, they will be the controllers of nature.1

The question of altering human nature also remains at the center of the developing case against Transhumanism and related proposals. Famed historian Francis Fukuyama, for example, has argued that contemporary biotechnology raises the possibility that it will alter human nature and thereby move us into a posthuman stage of history. This possibility poses a real danger to individual rights and threatens the foundation of democratic institutions:

This is important because human nature exists, is a meaningful concept, and has provided a stable continuity to our experience as a species. It is, conjointly with religion, what defines our most basic values. Human nature shapes and constrains the possible kinds of political regimes, so a technology powerful enough to reshape what we are will have possibly malign consequences for liberal democracy and the nature of politics itself.2

Though the deeper dangers of biotechnological alterations of humans have not yet manifested themselves, Fukuyama adds, one of the reasons I am not quite so sanguine is that biotechnology, in contrast to many other scientific advances, mixes obvious benefits with subtle harms in one seamless package.3 The essential correctness of Lewiss case is evident in the duration of major components in his rebuttal to Bernal, Stapledon, Haldane, Shaw and other enhancement proponents of his own day.

C. S. Lewis exhibited remarkable prescience in The Abolition of Man. Was there anything that he failed to see? Writing in the war years of the early 1940s, Lewiss perspective was understandably shaped by present circumstance and personal experience. As a result, he did not anticipate certain cultural and historical developments that have become critical to the rise of posthumanity thinking.

As noted, Lewis harbored a deep antipathy for faceless state institutions where atrocities are plotted out according to cost-benefit pragmatism and inhuman schemes are hatched in dingy meeting rooms. In such settings was the banality of evil expressed in war-torn Europe. Lewis does not appear to have anticipated the postwar power of the large corporation, the modern research university, and sophisticated mass media. Such shapers of 21st-century American culture, not the cumbersome state agencies of mid-century Europe, have taken the lead in developing the biotechnologies, educational techniques and persuasive prowess Lewis cautioned against. The user-friendly smile of the high-tech firm, not the icy stare of a government department, is the face of the new humanity. Moreover, justifications for enhancement research are not hammered out in centralized planning meetings, but tested on focus groups and winsomely presented in entertaining public lectures. Financial support for posthumanity comes not come from Big Brother bureaucracies but from Silicon Valley boardrooms.

The scope of research related to human enhancement is incomprehensibly vast and accelerating at an incalculable rate. Hundreds and perhaps thousands of university and corporate research facilities around the world are involved in developing artificial intelligence, regenerative medicine, life-extension strategies, and pharmaceutical enhancements of cognitive performance. An ever-increasing number of media products including movies, video games and novels promote Transhumanist and evolutionist themes. Each technological breakthrough is promoted as a matter of consumerist necessity despite the fact that personal electronic devices and the companies marketing them are increasingly intrusive and corrosive of personal freedoms. Innovative educational organizations such as Singularity University are forming around the Transhumanist ideal. Indeed, so immense, diverse and well-funded is the research network developing enhancement technologies that the collective financial and intellectual clout of all related projects is beyond calculating. Suffice it to say that the enhancement juggernaut is astonishingly large and powerful.

Tomorrow, Science and Scientism: The Prophetic Vision of C. S. Lewis.

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CS Lewis and Critical Reactions to Transhumanism - Discovery Institute

Covid-19 impact on Healthcare Nanotechnology (Nanomedicine) Market New Trends, Growth, Outlook, Overview, Application and Forecast 2020 to 2025:…

Healthcare Nanotechnology (Nanomedicine) Market 2020: Latest Analysis

Los Angeles, United States:-The report titled GlobalHealthcare Nanotechnology (Nanomedicine) Market is one of the most comprehensive and important additions toLimra Global Market Researcharchive of market research studies. It offers detailed research and analysis of key aspects of the global Healthcare Nanotechnology (Nanomedicine) Market . The market analysts authoring this report have provided in-depth information on leading growth drivers, restraints, challenges, trends, and opportunities to offer a complete analysis of the global Healthcare Nanotechnology (Nanomedicine) Market . Market participants can use the analysis on market dynamics to plan effective growth strategies and prepare for future challenges beforehand. Each trend of the global Healthcare Nanotechnology (Nanomedicine) Market is carefully analyzed and researched about by the market analysts.

Top Players of Healthcare Nanotechnology (Nanomedicine) Market are Studied: Amgen, Teva Pharmaceuticals, Abbott, UCB, Roche, Celgene, Sanofi, Merck & Co, Biogen, Stryker, Gilead Sciences, Pfizer, 3M Company, Johnson & Johnson, SmitH& Nephew, Leadiant Biosciences, Kyowa Hakko Kirin, Takeda, Ipsen, Endo International

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Global Healthcare Nanotechnology (Nanomedicine) Market is estimated to reach xxx million USD in 2020 and projected to grow at the CAGR of xx% during 2020-2026. According to the latest report added to the online repository of Limra Global Market Research the Healthcare Nanotechnology (Nanomedicine) Market has witnessed an unprecedented growth till 2020. The extrapolated future growth is expected to continue at higher rates by 2026.

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* Top Key Company Profiles.* Main Business and Rival Information* SWOT Analysis and PESTEL Analysis* Production, Sales, Revenue, Price and Gross Margin* Market Share and Size

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Table of Contents

Market Overview:This is the first section of the report that includes an overview of the scope of products offered in the global Healthcare Nanotechnology (Nanomedicine) Market , segments by product and application, and market size.

Market Competition by Player:Here, the report shows how the competition in the global Healthcare Nanotechnology (Nanomedicine) Market is growing or decreasing based on deep analysis of market concentrate rate, competitive situations and trends, expansions, merger and acquisition deals, and other subjects. It also shows how different companies are progressing in the global Healthcare Nanotechnology (Nanomedicine) Market in terms of revenue, production, sales, and market share.

Company Profiles and Sales Data:This part of the report is very important as it gives statistical as well as other types of analysis of leading manufacturers in the global Healthcare Nanotechnology (Nanomedicine) Market . It assesses each and every player studied in the report on the basis of main business, gross margin, revenue, sales, price, competitors, manufacturing base, product specification, product application, and product category.

Market Status and Outlook by Region:The report studies the status and outlook of different regional markets such as Europe, North America, the MEA, Asia Pacific, and South America. All of the regional markets researched about in the report are examined based on price, gross margin, revenue, production, and sales. Here, the size and CAGR of the regional markets are also provided.

Market by Product:This section carefully analyzes all product segments of the global Healthcare Nanotechnology (Nanomedicine) Market .

Market by Application:Here, various application segments of the global Healthcare Nanotechnology (Nanomedicine) Market are taken into account for research study.

Market Forecast:It starts with revenue forecast and then continues with sales, sales growth rate, and revenue growth rate forecasts of the global Healthcare Nanotechnology (Nanomedicine) Market . The forecasts are also provided taking into consideration product, application, and regional segments of the global Healthcare Nanotechnology (Nanomedicine) Market .

Upstream Raw Materials:This section includes industrial chain analysis, manufacturing cost structure analysis, and key raw materials analysis of the global Healthcare Nanotechnology (Nanomedicine) Market .

Marketing Strategy Analysis, Distributors:Here, the research study digs deep into behavior and other factors of downstream customers, distributors, development trends of marketing channels, and marketing channels such as indirect marketing and direct marketing.

Research Findings and Conclusion:This section is solely dedicated to the conclusion and findings of the research study on the global Healthcare Nanotechnology (Nanomedicine) Market .

Appendix:This is the last section of the report that focuses on data sources, viz. primary and secondary sources, market breakdown and data triangulation, market size estimation, research programs and design, research approach and methodology, and the publishers disclaimer.

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Covid-19 impact on Healthcare Nanotechnology (Nanomedicine) Market New Trends, Growth, Outlook, Overview, Application and Forecast 2020 to 2025:...

Nanomedicine Market Revolutionary Trends 2025 The News Brok – The News Brok

Nanomedicine Market Scope of the Report:

Factors and Nanomedicine Market execution are analyzed using quantitative and qualitative approaches to give a consistent picture of current and future trends in the boom. The study also allows for a detailed market analysis focused primarily on geographic locations. The Global Nanomedicine Market Report offers statistical graphs, estimates, and collateral that explain the state of specific trade within the local and global scenarios.

The worldwide market for Nanomedicine is expected to grow at a CAGR of roughly xx% over the next five years, will reach xx million US$ in 2025, from xx million US$ in 2018, according to a new study.

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segment by Type, the product can be split intoQuantum dotsNanoparticlesNanoshellsNanotubesNanodevicesMarket segment by Application, split intooncologyInfectious diseasesCardiologyOrthopedicsOthers

Market segment by Regions/Countries, this report coversNorth AmericaEuropeChinaJapanSoutheast AsiaIndiaCentral & South America

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* Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market.

* Market value (USD Million) and volume (Units Million) data for each segment and sub-segment

* Competitive landscape involving the market share of major players, along with the new projects and strategies adopted by players in the past five years

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The Nanomedicine Market report has 150 tables and figures browse the report description and TOC:

Table of Contents

1 Study Coverage

1.1 Nanomedicine Product

1.2 Key Market Segments in This Study

1.3 Key Manufacturers Covered

1.4 Market by Type

1.4.1 Global Nanomedicine Market Size Growth Rate by Type

1.5 Market by Application

1.5.1 Global Nanomedicine Market Size Growth Rate by Application

2 Executive Summary

2.1 Global Nanomedicine Market Size

2.1.1 Global Nanomedicine Revenue 2014-2025

2.1.2 Global Nanomedicine Production 2014-2025

2.2 Nanomedicine Growth Rate (CAGR) 2019-2025

2.3 Analysis of Competitive Landscape

2.3.1 Manufacturers Market Concentration Ratio (CR5 and HHI)

2.3.2 Key Nanomedicine Manufacturers

2.3.2.1 Nanomedicine Manufacturing Base Distribution, Headquarters

2.3.2.2 Manufacturers Nanomedicine Product Offered

2.3.2.3 Date of Manufacturers Enter into Nanomedicine Market

2.4 Key Trends for Nanomedicine Markets & Products

3 Market Size by Manufacturers

3.1 Nanomedicine Production by Manufacturers

3.1.1 Nanomedicine Production by Manufacturers

3.1.2 Nanomedicine Production Market Share by Manufacturers

3.2 Nanomedicine Revenue by Manufacturers

3.2.1 Nanomedicine Revenue by Manufacturers (2019-2025)

3.2.2 Nanomedicine Revenue Share by Manufacturers (2019-2025)

3.3 Nanomedicine Price by Manufacturers

3.4 Mergers & Acquisitions, Expansion Plans

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Global Testosterone Replacement Therapy Market 2020 Growth Analysis, Opportunities, Revenue and sales, Trends and Developments, Forecast by 2025 – Red…

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Global Testosterone Replacement Therapy Market 2020 Growth Analysis, Opportunities, Revenue and sales, Trends and Developments, Forecast by 2025 - Red...

Testosterone Replacement Therapy Sales Market Still Has Room to Grow With Emerging Players 2027 – The Daily Chronicle

(Augest 2020) SMI published a business research report on Testosterone Replacement Therapy Sales Market: Global Industry Analysis, Size, Share, Growth,Trends, and Forecasts 20202027. Research reportwith 110+ pages on market data Tables, Pie Chat, Graphs & Figures spread through Pages and easy to understand detailed analysis. The information is gathered based on modern floats and requests identified with the administrations and items.

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Geographical segmentation of the Testosterone Replacement Therapy Sales Market involves the regional outlook which further covers the United States, China, Europe, Japan, Southeast Asia and Middle East & Africa. This report categorizes the market based on manufacturers, regions, type and applications.

Testosterone Replacement Therapy Sales Market: Competitive Landscape

Leading players operating in the global Testosterone Replacement Therapy Sales market include AbbVie, Endo International, Eli lilly, Pfizer, Actavis (Allergan), Bayer, Novartis, Teva, Mylan, Upsher-Smith, Ferring Pharmaceuticals, Kyowa Kirin, Acerus Pharmaceuticals.

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Important Data Available In This Report:

An Overview of the Impact of COVID-19 on this Market:

The pandemic of COVID-19 continues to expand and impact over 175 countries and territories. Although the outbreak appears to have slowed in China, COVID-19 has impacted globally. The pandemic could affect three main aspects of the global economy: production, supply chain, and firms, and financial markets. National governments have announced largely uncoordinated, country-specific responses to the virus.

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Testosterone Replacement Therapy Sales Market Still Has Room to Grow With Emerging Players 2027 - The Daily Chronicle

LPCN: Tlando: Target Action Date This Friday – Zacks Small Cap Research

By John Vandermosten

NASDAQ:LPCN

READ THE FULL LPCN RESEARCH REPORT

Up and Coming Milestones

Tlando PDUFA date August 28, 2020

Primary endpoint results for LiFT (LPCN 1144) 4Q:20

Patent Infringement trial February 2021

Complete Phase II LiFT (LPCN 1144) 2Q:21

Second Quarter 2020 Operational and Financial Results

On August 6, 2020 Lipocine (NASDAQ:LPCN) filed its second quarter 2020 10-Q and posted its earnings release for the three month period ending June 30, 2020. The company reported zero revenues and a net loss per share of ($0.13) compared to prior year revenues of zero and loss of ($0.14) per share. Activity during the second quarter revolved around several items including presentation at the American Urological Association (AUA) conference, demonstration of treatment potential for LPCN 1144, investigational new drug clearance for LPCN 1148, affirmation of the USPTO decision and the dismissal of a shareholder lawsuit. The companys shares also exceeded $1.00 in June, and have remained above this level, allowing Lipocine to regain compliance with NASDAQ minimum bid requirements. The most important item on the calendar is the FDAs response to Tlandos NDA submission, which is expected on or before August 28th.

We anticipate that upon approval, Lipocine will find a partner to commercialize Tlando and use associated upfront and milestone payments to further develop the existing portfolio, especially LPCN 1144 and LPCN 1148. Potential licensees are waiting until approval is granted before performing their due diligence. This suggests that a deal would be announced in the fourth quarter of 2020 rather than in the weeks following an assumed approval.

Operational expenses for 2Q:20 were $4.2 million, up 26% and net loss totaled ($6.4) million or ($0.13) per share. Research and development expenses totaled $2.5 million. The 16% rise over prior year amounts reflects increased costs related to the LiFT study and higher personnel expenditures offset by a decrease in amounts related to the ABPM study, lower spend on the Tlando XR program and a fall in manufacturing costs for LPCN 1107. General and administrative costs rose 41% over last years second quarter to $2.0 million on an expansion in legal expenditures related to the Clarus dispute and an increase in personnel costs offset by lower marketing expenses, administrative travel and other expenses. A rise in the share price increased the warrant liability and required the recognition of a $2.1 million non-cash loss in other income.

Cash and marketable securities balance was $18.2 million as of June 30, 2020. There is another $5 million of restricted1 cash which will remain on hold until Tlando is approved. Current and non-current debt is carried on the balance sheet at $6.3 million. Cash burn for 2Q:20 was approximately ($4.1) million and net cash provided by financing was $11.7 million representing a stock offering and warrant proceeds partially offset by a small amount of debt repayment.

Tlando

On November 11 of last year, Lipocine announced that it had received a complete response letter (CRL) for Tlando. The CRL identified one deficiency stating that the trial did not meet one of the three secondary endpoints for maximal testosterone concentrations (Cmax). No deficiencies related to chemistry, manufacturing and controls were noted. FDA guidelines call for 85% of subjects to achieve a Cmax below 1500 ng/dL and no more than 5% of subjects presenting a Cmax between 1800 ng/dL and 2500 ng/dL and 0% above 2500 ng/dL. In the most recent dosing validation (DV) study, 85% of subjects were below 1500 ng/dL and 7% were between 1800 ng/dL and 2500 ng/dL. Although there were small variations from the FDA guidelines in the original SOAR study for subjects above 2500 ng/dL, the FDA did not identify these as a deficiency during the original New Drug Application (NDA) submission.

Following the Post Action meeting with the FDA, Lipocine was advised to address the outstanding deficiencies with a reanalysis of existing data. This recommendation relieved Lipocine of the time and cost of an additional trial and also allowed the resubmission of the Tlando NDA in February. A target action date of August 28th was provided. While the resubmission is a positive, Tlando has faced significant hurdles gaining the favor of the FDA. We published a note on February 25th that discussed details regarding the resubmission.

LPCN 1144

Lipocine announced in August 2018 the pursuit of a new indication in nonalcoholic steatohepatitis (NASH). We discuss the indication and Lipocines efforts in an earlier piece that can be accessed here. Full enrollment of 36 subjects was achieved in November 2018.

In January 2019, Lipocine announced meaningful liver fat reduction in patients participating in its Liver Fat Study and informed investors that the company had filed an investigational new drug (IND) application to begin a Phase II study for NASH. Since LPCN 1144 is the same molecule as TLANDO, for which there were numerous safety studies completed, LPCN was allowed to perform a proof of concept (POC) clinical study under the original IND to assess liver fat changes. This 36-person study was conducted in hypogonadal men at risk of developing non-alcoholic steatohepatitis (NASH) and results were measured using the magnetic resonance imaging proton density fat fraction (MRI-PDFF) technique. Topline results were announced in 1Q:19 demonstrating a 4.0% to 8.2% percentage point reduction in liver fat depending on baseline liver fat category. We discussed the results in further detail in our NASH Topline article.

Lipocine launched its Phase II clinical study for LPCN 1144 and dosed its first patient last September. Prior to the start of the trial, Lipocine announced that the FDA would allow the Phase II LiFT trial to enroll eugonadal patients in addition to the NASH patients that were initially targeted. This expansion was based on research that we discussed in a July 29th note. The study is anticipated to last for 18 months and cost approximately $8 million.

LiFT, an acronym of Liver Fat intervention with oral Testosterone, is a paired biopsy Phase II study in NASH subjects. The study design will employ a three-arm, double-blind, placebo-controlled structure and enroll approximately 75 biopsy confirmed male NASH subjects with a NAS2 score of greater or equal to four. The primary endpoint for the study is 12-week MRI-PDFF liver fat reduction and the first patient was enrolled in 3Q:19. As for the anticipated timeline, Lipocine expects top line liver fat reduction data in 4Q:20 as measured by MRI-PDFF at 12 weeks. Biopsy data at 36 weeks is expected to be available in the second quarter of 2021.

Exhibit I LiFT Study Timeline3

NASH Environment

A lot has happened in the NASH space in 2020. Genfit (GNFT) announced that it will halt development of elafibranor after it failed to distinguish itself compared to placebo earlier this year. CymaBay (CBAY) announced that the FDA had lifted the hold on seladelpars Phase II study last month. No evidence was found for liver injury for the drug and the trial is expected to resume. Intercepts (ICPT) OCA received a complete response letter from the FDA in late June noting that the agency remains uncertain that the benefits of the drug outweigh the risks. Viking (VKTX) is conducting the Phase IIb VOYAGE trial for VK2809 which is still ongoing. A bright spot in the space has been results from Akeros (AKRO) Phase IIb trial for efruxifermin in NASH which were announced June 30. The study found that 48% of patients had fibrosis improvement of at least one stage with a 62% response rate. Fibrosis improved by at least two stages for 28% of the group with a 38% response rate and 48% experienced NASH resolution without worsening of fibrosis across all dose groups.

LPCN 1148

Lipocine is preparing to develop its testosterone molecule to treat NASH cirrhosis patients. While the target market is smaller than that of pre-cirrhotic NASH, there are no other FDA approved products available. The inverse relationship between testosterone and sarcopenia and the increased risks of advancing NASH cirrhosis validates this pursuit. Pending funding, Lipocine plans to initiate a proof of concept trial to evaluate the potential of this candidate. The companys Investigational New Drug (IND) application was cleared by the FDA in May 2020. We anticipate Lipocine will launch the Phase II trial after the start of commercialization of Tlando and upon availability of sufficient capital to fund it. Management has guided to a 4Q:20 or 1Q:21 start.

Exhibit II Lipocine Pipeline4

Markman Hearing

On March 26th, Lipocine announced the outcome of the Markman Hearing, also known as a claim construction hearing. This meeting is an important precursor to a patent infringement lawsuit and provides the definitions of terms critical for a jurys determination on whether or not a patent has value. A patent should not be too specific, as it provides insufficient protection to an invention, or too broad, in which case a court may rule it indefinite. In the hearing order5, Judge Bryson did not agree with most of Clarus claims and sided with Lipocine on the majority of definitions and clarifications. While the terms and definitions are subject to an evolving construction, the order is favorable to Lipocines dispute against Clarus. While this order could be appealed again, it is unlikely in the opinion of Lipocines counsel. Lipocine and Clarus are currently engaged in the fact discovery phase of the lawsuit and the jury trial is anticipated to take place in February 2021. Lipocine need only prevail on one claim to merit damages, which places them in a strong position to succeed in the trial or provide incentive for Clarus to settle.

USPTO Decision Affirmed

The US Court of Appeals affirmed the decision of the USPTO in April 2020 to grant Lipocines Priority Motion in the interference case that cancelled Clarus claims to the 428 patent in January 2019. The USPTO, through its Patent Trial and Appeal Board (PTAB), had granted Lipocines priority motion in the related interference case and entered adverse judgment against Clarus. As we have previously shared, this outcome was expected as it is rare for a federal court to overturn a USPTO ruling. As a reminder, in 2Q:19 Lipocinefiled suitagainst Clarus alleging that Jatenzo infringed on six of Lipocines patents. The injunction filing may slow down commercialization of Jatenzo and force Clarus to come to the table to negotiate a settlement. While the cost of pursuing such legal action could be high, we anticipate by the time the case works its way through the courts, cash flow from Tlando could be sufficient to support the legal efforts.

Publications and Abstracts

Results from Lipocines Liver Fat Study were published in Hepatology Communications in an article entitled LPCN 1144 Resolves Non-Alcoholic Fatty Liver Disease In Hypogonadal Males." The study served to identify the prevalence of non-alcoholic fatty liver disease (NAFLD) in hypogonadal males and quantify the beneficial impact of LPCN 1144 on hypogonadism. 36 hypogonadal males were evaluated using MRI-PDFF measurements for liver fat. 81% of those with baseline liver fat equal to or greater than 5% showed improvement in liver fat content and NAFLD resolved in one-third of the group at six weeks and 48% after 16 weeks. The paper concluded that treatment with LPCN 1144 resolved NAFLD in about half of affected patients without any safety signals.

Lipocine submitted several abstracts to the American Urological Association (AUA) Virtual Experience, which took place from May 15 to 17, 2020. Three titles were presented.

Impact of a new oral testosterone undecanoate on blood pressure and cardiovascular risk was presented by Dr. Mohit Khera which investigated the chronic use of testosterone replacement therapy (TRT) on cardiovascular risk. Jatenzo, Xyosted and Tlando were assessed in their impact on blood pressure and cardiovascular risk in hypogonadal men. Marginal increases in blood pressure were observed and no meaningful impact on cardiovascular risk was noted.

A novel oral testosterone therapy restores testosterone to eugonadal levels without dose titration was presented by Dr. Martin Miner and highlights the shortcomings of dose titration when prescribing TRT. The abstract concluded that fixed dose Tlando normalizes testosterone levels in hypogonadal patients while avoiding the potential problems associated with titrated TRT.

Effects of a new oral testosterone undecanoate (TLANDO) therapy on liver was presented by Dr. Irwin Goldstein and compares oral methyltestosterone (MT) with TRT in males deficient in endogenous testosterone. The study results suggested that unlike MT, Tlando has no adverse effects on liver and can be used for an extended period to potentially reduce liver fat.

Milestones

Tlando CRL November 9, 2019

Tlando FDA post action meeting January 2020

Resubmission of Tlando NDA February 2020

Investigational New Drug (IND) clearance for LPCN 1148 May 2020

Wajda v. Patel shareholder suit dismissed July 2020

Tlando PDUFA date August 28, 2020

Primary endpoint results for LiFT (LPCN 1144) 4Q:20

Patent Infringement trial February 2021

Complete Phase II LiFT (LPCN 1144) 2Q:21

Summary

Since our previous update, Lipocine has participated in scientific conferences, published an article in the journal Hepatology Communications and advanced several months towards the upcoming August 28 PDUFA date for Tlando. Assuming a favorable outcome for the application, Lipocine will seek a commercialization partner and should receive upfront and milestone proceeds in conjunction with a deal. The Phase II LiFT trial continues to be a bright spot for the company and is potentially able to address a large unmet need in NASH patients in contrast to other programs which have met with difficulty. Management has guided towards a year-end readout of LiFT trial results. Lipocine is also developing LPCN 1148 for cirrhosis patients which was recently given clearance to begin a Phase II study. While we do not see this program entering the clinic until sufficient capital is available, we do think it will advance if Phase II data for LPCN 1144 are positive.

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1. Tlando was not approved by the FDA by May 31, 2018, and therefore Lipocine is required to maintain $5.0 million of cash collateral at Silicon Valley Bank (the lender) until such time as it is approved by the FDA.

2. NAS: NAFLD (Non-alcoholic fatty liver disease) Activity Score. Discussion of the metric can be found here.

3. Source: Lipocine Corporate Presentation May 2020.

4. Source: Lipocine Corporate Presentation July 2020.

5. A link to the Markman Hearing Order can be found on this page: https://ir.lipocine.com/presentations

Link:
LPCN: Tlando: Target Action Date This Friday - Zacks Small Cap Research