Sigilon Therapeutics Announces $80.3 Million Series B Financing to Advance Shielded Living Therapeutics to the Clinic – BioSpace

Proceeds will advance first-in-human clinical trial for hemophilia A in 2020 and progression and expansion of Sigilons pipeline

CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Sigilon, Inc., a biotechnology company developing functional cures for patients with chronic diseases through its Shielded Living Therapeutics platform, today announced that it has completed a $80.3 million Series B financing. The funding will support the first-in-human clinical trial of Sigilons novel encapsulated cell therapy for hemophilia A, expected to begin in the first half of 2020, as well as continued advancement and expansion of Sigilons programs in rare blood disorders, lysosomal diseases and endocrine and immune disorders.

Canada Pension Plan Investment Board (CPP Investments), Longevity Vision Fund and funds managed by BlackRock joined founding investor Flagship Pioneering and other existing investors, including Eli Lilly and Company, in the financing round, which brings Sigilons total funding to more than $195 million.

Sigilon is driven to liberate patients from the fear of living with serious chronic diseases, and from alternative therapeutic approaches, said Rogerio Vivaldi, M.D., President and CEO of Sigilon. Our Shielded Living Therapeutics platform is designed to give patients who have chronic diseases a convenient, safe, long-term therapeutic benefit. We believe encapsulating engineered human cells in our proprietary matrix will enable us to deliver controlled doses of therapeutic proteins without the need for immunosuppression and without the risks associated with modifying patients genomes. We are pleased to welcome an exceptional group of investors who share our vision of offering more hope and less fear to patients and their caregivers as we enter the clinic with our lead program and continue to advance our other programs toward the clinic.

Sigilons Shielded Living Therapeutics platform offers patients with chronic disease the prospect of relief without disrupting their lives, said Douglas Cole, M.D., Managing Partner at Flagship Pioneering and Chairman of the Board at Sigilon. The near-term transition to clinical development and the platforms breadth and progress reflect the power and productivity of Sigilons approach. Successful conclusion of this financing puts the company in a strong position to build further value.

Sigilon was founded to develop immune-protected, bio-engineered cells to restore normal physiology in a wide range of diseases without immune rejection, liberating patients from the challenges associated with existing treatments for serious chronic diseases. Treatments based on Sigilons Shielded Living Therapeutics platform combine advanced cell engineering with cutting-edge innovations in biocompatible materials to pioneer a new class of medicines that have been designed to provide durable, redosable, controllable and safe potential treatment for chronic diseases.

Sigilons lead investigational therapy for hemophilia A, SIG-001, has received an Orphan Drug Designation from the U.S. Food and Drug Administration (FDA). Sigilon expects to initiate a clinical trial of SIG-001 in the first half of 2020.

About Sigilon Therapeutics

Sigilon Therapeutics is developing functional cures for chronic diseases through its Shielded Living Therapeutics platform. Sigilons therapeutics consist of novel human cells engineered to produce the crucial proteins, enzymes or factors needed by patients living with chronic diseases such as hemophilia, diabetes and lysosomal disorders. The engineered cells are protected by Sigilons Afibromer biomaterials matrix, which shields them from immune rejection and fibrosis. Sigilon was founded by Flagship Pioneering in conjunction with Daniel Anderson, Ph.D., and Robert Langer, Sc.D., of the Massachusetts Institute of Technology.

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Sigilon Therapeutics Announces $80.3 Million Series B Financing to Advance Shielded Living Therapeutics to the Clinic - BioSpace

The Constellation of Frank Stella – The New York Times

STARS THE KIND that appear in the cosmos have coordinates, not addresses, and the same is true for certain earthbound luminaries, too. One gloomy November morning, I follow my GPS to an anonymous set of buildings in the Hudson Valley. The rain buckets down forebodingly, but I know Im on the right track when I make out a set of immense cast-aluminum and stainless-steel sculptures by the side of the road, a few of them distinctly stellar in shape. For good measure, the name Stella is spray-painted on a piece of wood indicating the entrance.

This hangar-like structure, about a 90-minute drive north of Manhattan, has been Frank Stellas studio for the past two decades. The vast space, more easily traversed by golf cart than on foot, is divided into rooms for both fabrication and display. Here, I find more star variations: The grandest has 12 points and is made of glossy black carbon fiber. At over 20 by 20 feet, its puffily imposing and gently comic. Its neighbors are a pair of cleverly interlocking wooden stars, one in teak, another in birch, the humble quality of the carpentry a counterpoint to their complexity of form, reminiscent of da Vincis illustrations of the Platonic solids. More futuristic are two slightly smaller ones made from polished stainless steel; theyre what might have resulted if Buckminster Fuller had created cat toys for giants. When I look closer, I notice that some of them have built-in bases on their bottommost points that resemble little shoes: These stars have their feet planted on the ground.

As does the man himself. Stella, dressed in khakis and a blue fleece zip-up that has Team Stella stitched on it in white, is now 83, but hes retained the scrappy, unpretentious persona hes famous for, as well as the curly hair and glasses. This is the man who, nearly six decades ago, gave Minimalism its great tagline by proclaiming: What you see is what you see, his words a rallying cry for what art could be, and, equally, could do without. A fixed light in American arts galaxy since the 1960s, he has arguably influenced visual representation as powerfully as Andy Warhol.

Unlike many mid-20th-century artists who rose fast only to seemingly collapse under the pressure of their own reputations, Stella kept pushing himself by using new forms, materials and technologies. When he felt hed reached the limits of the flat canvas, he built out from it in reliefs inspired by Moby-Dick and Polish villages. In the 1980s and 90s, he made metal sculptures that looked like race cars or jet engines turned inside out, as well as unwieldy canvases covered in Pop-colored riots of form operatic assemblages of cones, pillars and graffiti-like brushwork, like something Charlie Sheens character might have had in his home in the 1987 film Wall Street. That the godfather of Minimalist painting turned into a progenitor of the contemporary baroque has always flummoxed critics.

Perhaps the secret to his longevity, his decade-upon-decade habit of creating, is again a matter of balanced forces, the measures hes taken to temper his bright-burning ambition. When we meet, the artist has just celebrated the arrival of his fifth grandchild, Sophie. (Stella, who has five children, has been married to Harriet McGurk, a pediatrician, since 1978, and they live in the same house in Greenwich Village hes owned since the 1960s; his first wife was the art critic Barbara Rose.) He seems to lack any real self-destructive impulse; he never succumbed to matters of lifestyle. When I ask him if he has any vices, he dodges. You have to ask my wife, he says dryly.

He has (at least) two, it turns out: cigars and fast cars, both of which have informed his work in various ways, from sculptures based on three-dimensional representations of his own smoke rings to his use of technological innovations derived from the auto industry, like carbon-fiber skin over steel or aluminum frames. In 1982, he was caught driving his silver Ferrari 105 miles per hour in a 55-mile-per-hour zone on the Taconic State Parkway, and in lieu of jail time, he delivered public lectures on his painting. His racing days are now long over, and he can no longer do much of the physical labor involved in art-making. And so it might seem hes come full circle, returning to the deceptively simple geometries he was making six decades ago, only now expanded into three dimensions.

Tentatively scheduled to open in May, a new show at the Aldrich Contemporary Art Museum, in Ridgefield, Conn., Frank Stellas Stars, A Survey, will focus on Stellas use of the form at both ends of his career. Many artists have become fixated on the creation of a particular shape or motif throughout their lives: Jasper Johns and flags; Pablo Picasso and guitars; Louise Bourgeois and spiders. The ceaseless exploration of one form helps create an artists aesthetic universe, and Stella is part of this tradition. Stella means star in Italian, but the artists interest in the shape in geometry, the star polygon is recognized in both two and three dimensions with varying numbers of points is spatial, not narcissistic. He initially made star drawings in the 1960s (a set of lithographs from 1967 titled Star of Persia I; and II, first exhibited at the Aldrich in 1969, will be included in the show), though the majority of the exhibition will showcase the more recent sculptural work I observed in his studio, a study of the potential of the star in different materials, scales and formal variations, never repeated in the same way. Even with something as stable and as knowable as the star, Stella is able to reinvent it every time he approaches it and make you look at it in a different way, says Richard Klein, the Aldrichs director of exhibitions.

Star polygons have long been bound up with all sorts of human metaphysical projection, used as religious symbols and in ranking systems. As motifs associated with honor and glory and jobs well done, they decorate everything from national flags and sheriffs badges to toilet-training charts. But most of all, they symbolize the limits of human understanding, their geometric representation inseparable from their existence as celestial objects, luminous spheres of gas held together by their own gravity. Their lyricism aside, stars are our most archaic form of navigation as well as our best clues to the dimensions of the universe. Because light travels at a finite speed, the glow of a distant star is perceived by our earthbound eyes long after it has ceased to exist. Similarly finite, perhaps, is the rate of human understanding: In art history, were continually revising the past based on our relative position to it; the importance of an artist or an entire movement might become visible only in retrospect. So what, one wonders, is left to say about a man who has been famous now since the 1950s, and all the more so at a time in which figuration and portraiture have made comebacks, and when were all questioning arts relevance in a scary new decade?

STELLA NEVER WENT to art school, but from an early age, he had a no-nonsense relationship with a paintbrush: His father, a gynecologist, paid his way through medical school by painting houses, with Stella as his young assistant. My father would make me sand the floor; we had to do the sanding and scraping before you could hold the brush and then paint on the wall. So it was that kind of apprenticeship and familiarity, he says. While repainting the porch of their fishing cabin in New Hampshire Stella grew up in the Boston suburb of Malden his mother, a fashion illustrator and homemaker, decided to make a Jackson Pollock on the floor, dripping the paint in swirls. And my father had to explain to her that maybe it was good in art, but it wasnt going to work as a floor covering because we didnt have any sealer.

A story in one of his mothers Vogue magazines, featuring models posed in front of a painterly Franz Kline-esque Abstract Expressionist backdrop, provided him with an early clue that art wasnt only about figuration. At Phillips Academy in Andover, Mass., in the early 50s, when European abstraction was a prevailing force in studio art, Stella was especially influenced by the work of Hans Hofmann, a kind of proto-Abstract Expressionist from the 40s, and the Bauhaus color theorist Josef Albers. I had no mimetic ability, Stella tells me, but I was never interested in finding one, or cultivating one. No, I worked directly with the materials, actually. The big deal in postwar American painting was its materiality, and so that was heaven for me.

He started painting more seriously at Princeton, where he played lacrosse and wrestled, majored in history and studied art with William Seitz, who would become a curator at the Museum of Modern Art, and with the painter Stephen Greene. After graduating in 1958, Stella moved to New York. When I left school, he says, I wanted to see what it was like to paint all the time. And at that time, it was between the Korean War and Vietnam, and we still had selective service. My induction exam was in September, so I thought, Ill go to New York [in the meantime], get a place, and Ill just paint and work and do odd jobs, and see what its like to do nothing but paint for three or four months. And then, unfortunately or rather, fortunately I failed my induction exams. And when I called up my father, I said, Im sorry, I have to go back to New York, I failed the exam. He said, Too bad, it would have made a man of you. The most important thing for them was that I shouldnt be a burden on society. He pauses. And we know what they meant by society.

Stella was only 23 when his work was included in a group show, Sixteen Americans, at MoMA in 1959. His Black Paintings bands of matte enamel (he used house painters brushes and house paint) separated by pinstripes of exposed canvas startled critics for their extremity of reduction, their intentionally flat affect, their refusal to appease. Cool, clever, and somehow less angstily reverential in feel than the Abstract Expressionist era that it helped supplant, Stellas work is now widely seen as a crucial evolutionary link in modern art, and a catalyst for the Minimalist movement to come. His emphasis on two-dimensional surfaces was a clear rejection of the idea of painting as a window into a three-dimensional space.

His participation in the MoMA show, alongside Jasper Johns, Robert Rauschenberg, Ellsworth Kelly and Louise Nevelson, launched his career four of his paintings were included in the exhibition but his first gallery show, with New Yorks Leo Castelli a year later, resulted in few sales. Stella eked out a living painting houses, renting cold-water flats and sharing studio space with Carl Andre and Hollis Frampton, his friends from Phillips Academy, but listening to him, its impossible not to feel nostalgia for a time in which you could arrive in Manhattan, these days largely a gated community for the wealthy, and simply go about making your art.

THERES AN ELEMENT of luck and things like that to it, but the fact of the matter is that the system was pretty supportive, says Stella when I remark on how he seemed to be exactly the right artist at exactly the right time. In New York, he was granted a sense of license to do whatever he wanted with paint, inspired by the artists he revered, among them Willem de Kooning, Barnett Newman and Pollock. Stella found his own canvases growing larger large enough to have to be placed on the floor. They were no longer easel paintings, he says. Basically, I was standing up in front of a painting that was a little bit bigger than I was, and that was the working on it, like the way you would paint a wall in a house. And that was the kind of thing that I felt comfortable with. He singles out the abstract painter Helen Frankenthaler, who studied under Hofmann, as the artist he believes was one of the most undervalued in her lifetime. They were always interesting, always good, and very, very difficult paintings she made, and she was lucky if she could sell any of them, he recalls. Early in his career, she proposed a trade with him, but he was too intimidated to take her up on it.

When I ask him if hes in touch with anyone from that time, he shakes his head. No. The problem now is everybodys dead or dying. Im in the category of Is he still alive? artists. Yeah, you laugh, but I can show you a letter a guy was asking if I was still alive because he liked my work so much.

By the end of the 1960s, Stella had lost interest in flat surfaces. He started making constructions of felt, paper and wood that protruded from the surface of a stretched canvas in a relief. He named these works, like 1971s Chodorow II, after synagogues destroyed by the Nazis. In a way, the work could be seen as a kind of inverse of the type of painting that had dominated Western art since the Renaissance, which drew viewers into the canvas. The idea behind it all was to build a painting rather than paint a painting, says Stella. If I built it first, it was all mine, and then I could paint on that and thats all. The simple story would be that the Minimalist turned Maximalist when the former wore out its usefulness.

On many occasions, material experimentation offered a pathway forward: Thats a kind of necessity, because you get bogged down, you get worried. Youre always looking for something, as they say, a way out of the darkness. And its inevitable that you look to things. You look to what other people are doing, and you look to whats available, and you cant help looking for things. Mostly you look within the art world, but that seems like a limited vision, so you have to look outside. You have to get with the real world eventually.

In at least one such moment, Stella found himself compelled to look back in order to move forward. He used his 1982-83 residency at the American Academy in Rome to delve into the legacy of Caravaggio and Rubens. That research led eventually to Working Space, his 1986 book derived from a series of lectures that he delivered at Harvard in the early 80s, in which he framed his new work as an answer to a crisis in abstract painting. Stellas Moby-Dick series, which he began that year and continued until 1997, considered abstractions ability to illustrate narratives, with silhouettes alluding to waves and ships. The 90s and early aughts were critically tough for Stellas hectic forms, and yet many works from this time his mural-size Moby-Dick-inspired 1992 print, The Fountain, for example, or his underrated work in rugged painted metal, especially 2004s Ngebat, a twisted construction of stainless steel and carbon fiber now seem freshly exhilarating. You could argue that every artist working in Europe and America today has, in some fashion, been unconsciously influenced by Stella, and there are those who more explicitly credit him as an influence, such as the assemblage artist Jessica Jackson Hutchins and the abstract painter Sarah Morris.

Before I leave, Stella takes me on a tour of recent work, leading me behind the curtain hanging in the back of the studio. So, now youre going into the space where no women are allowed, he jokes. And lo, there I behold Stellas industrial sander, his spray-painter, as well as a glimpse of new work being fabricated for a private collector.

If entropy is the natural direction of all things the laws of physics, anyway, as well as contemporary art some things in our universe do, in fact, remain constant: Stellas star, at least, built on the principles of space, light, speed and seemingly infinite expansion, is unlikely to dim from art history anytime soon. Basically, everything is about being an artist, he says as we part ways. He pulls out a cigar as I thank him and gather my coat and umbrella. Youre welcome, he smiles. And dont say anything about the smoking.

Its an open question just how well Stellas ethos has fared over time. Once so thrillingly radical, Minimalist painting has inevitably lost some of its charge over the years; at a time in which art is often wrapped up in social and political questions, shunning pictorial representation and symbolic meaning for the essentials of color, shape and composition can feel oddly safe, something everyone can get behind: colorful geometries that could be printed on an Ikea duvet. And yet the sheer scale and panache of Stellas early work are undeniable. At the Art Institute of Chicagos Modern Wing, I often observe tourists stopping dead in their tracks in front of Hatra I, one of the first Protractor paintings Stella made beginning in 1967, which consist of sweeping, intersecting arcs, the shape of the canvas echoing that of the paint. Glowing with bright acrylic and measuring 20 by 10 feet, it still imparts a contact high. Sitting in Stellas presence and revisiting his work with him, I think what a misunderstanding it is to consider Minimalism as soulless or academic, a mere visual palate cleanser. On the contrary, it seeks feelings less easily named, an almost somatic response, a full-body awareness. What you see is what you see, but what you feel has always been important, too.

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The Constellation of Frank Stella - The New York Times

Need Vitamin C Supplementation? Eat these Foods – Longevity LIVE

The COVID-19 pandemic is causing shortages of important medical devices, foods and products. You may be hoping to boost your immunity with additional vitamin C. Its important to know that fruits and vegetables are still the best food sources of vitamin C. Buy fresh (or even frozen) foods rich in vitamin C. Heres what you need to look out for.

Vitamin C, also called ascorbic acid, plays many important roles in the body. This vitamin is key to the immune system, helping prevent infections and fight disease.

It is a water-soluble vitamin thats found in many foods, mostly in fruits and vegetables. Well-known for being a potent antioxidant, it also has positive effects on skin health and immune function. Vital for collagen synthesis, connective tissue, bones, teeth and your small blood vessels.

The human body cannot produce or store it. Therefore, its essential to consume it regularly in sufficient amounts.

The current daily value (DV) for vitamin C is 90 mg.

The list is sourced fromMyFoodData.com who sourced the information from the U.S. Agricultural Research Service Food Data Central.

Other Vitamin C Rich Foods

MyFoodData.com now releases the USDA data in a flat spreadsheet file format for public use. Find out more here.

According to Medical News Today, cooking may reduce the amount of the vitamin in fruits and vegetables. To optimize, the ODS recommends steaming or microwaving these foods.

Vitamin C is vital for your immune system, connective tissue and heart and blood vessel health, among many other important roles.

Not getting enough can have negative effects on your health.

While citrus fruits may be the most famous source of this particular vitamin, a wide variety of fruits and vegetables are rich in this vitamin and may even exceed the amounts found in citrus fruits.

By eating some foods suggested above each day, your immunity should be boosted.

Read this complete guide to boosting your immune system.

What are vitamins and how do they work? https://www.medicalnewstoday.com/articles/195878

Vitamin C in Disease Prevention and Cure: An Overview Shailja Chambial,Shailendra Dwivedi,Kamla Kant Shukla,Placheril J. John,andPraveen Sharma

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783921/

Top Vitamin C Foods By Nutrient Density (Vitamin C Per Gram)

MyFoodData.com and U.S. Agricultural Research Service Food Data Central

20 Best foods for vitamin C Medical News Today: https://www.medicalnewstoday.com/articles/325067#does-cooking-affect-vitamin-c

National Institute of Health: Vitamin C Fact Sheet for Health Professionals https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/

20 Foods That Are High in Vitamin C Healthline: https://www.healthline.com/nutrition/vitamin-c-foods

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Need Vitamin C Supplementation? Eat these Foods - Longevity LIVE

Anti-Senescence Therapy Market Growth, Sales, Trends, Supply, Forecast By 2026|Unity Biotechnology, Siwa Therapeutics, Calico LLC – Weekly Wall

Los Angeles, United State Complete study of the global Anti-Senescence Therapy market is carried out by the analysts in this report, taking into consideration key factors like drivers, challenges, recent trends, opportunities, advancements, and competitive landscape. This report offers a clear understanding of the present as well as future scenario of the global Anti-Senescence Therapy industry. Research techniques like PESTLE and Porters Five Forces analysis have been deployed by the researchers. They have also provided accurate data on Anti-Senescence Therapy production, capacity, price, cost, margin, and revenue to help the players gain a clear understanding into the overall existing and future market situation.

Key companies operating in the global Anti-Senescence Therapy market include _Unity Biotechnology, Siwa Therapeutics, Calico LLC, AgeX TherapeuticsInc, Numeric Biotech, Human Longevity, Inc. (HLI), Cleara Biotech, OisinBiotechnologies, Recursion Pharmaceuticals, Sierra Sciences, Proteostasis Therapeutics, Senolytic Therapeutics, Allergan

Access PDF Version of this Report at: https://www.qyresearch.com/sample-form/form/1493403/global-anti-senescence-therapy-market

Segmental Analysis

The report has classified the global Anti-Senescence Therapy industry into segments including product type and application. Every segment is evaluated based on growth rate and share. Besides, the analysts have studied the potential regions that may prove rewarding for the Anti-Senescence Therapy manufcaturers in the coming years. The regional analysis includes reliable predictions on value and volume, thereby helping market players to gain deep insights into the overall Anti-Senescence Therapy industry.

Global Anti-Senescence Therapy Market: Types of Products- Gene TherapyImmunotherapyOthers

Global Anti-Senescence Therapy Market: Applications- Cardiovascular DiseasesNeural Degenerative DiseasesOphthalmology DisordersOthers

Competitive Landscape

It is important for every market participant to be familiar with the competitive scenario in the global Anti-Senescence Therapy industry. In order to fulfil the requirements, the industry analysts have evaluated the strategic activities of the competitors to help the key players strengthen their foothold in the market and increase their competitiveness.

Key companies operating in the global Anti-Senescence Therapy market include _Unity Biotechnology, Siwa Therapeutics, Calico LLC, AgeX TherapeuticsInc, Numeric Biotech, Human Longevity, Inc. (HLI), Cleara Biotech, OisinBiotechnologies, Recursion Pharmaceuticals, Sierra Sciences, Proteostasis Therapeutics, Senolytic Therapeutics, Allergan

Key questions answered in the report:

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Major Table of Contents:-

Executive Summary

1 Industry Overview of Anti-Senescence Therapy

1.1 Definition of Anti-Senescence Therapy

1.2 Anti-Senescence Therapy Segment by Type

1.3 Anti-Senescence Therapy Segment by Applications

1.4 Global Anti-Senescence Therapy Overall Market

1.4.1 Global Anti-Senescence Therapy Revenue (2014-2025)

1.4.2 Global Anti-Senescence Therapy Production (2014-2025)

1.4.3 North America Anti-Senescence Therapy Status and Prospect (2014-2025)

1.4.4 Europe Anti-Senescence Therapy Status and Prospect (2014-2025)

1.4.5 China Anti-Senescence Therapy Status and Prospect (2014-2025)

1.4.6 Japan Anti-Senescence Therapy Status and Prospect (2014-2025)

1.4.7 Southeast Asia Anti-Senescence Therapy Status and Prospect (2014-2025)

1.4.8 India Anti-Senescence Therapy Status and Prospect (2014-2025)

2 Manufacturing Cost Structure Analysis

2.1 Raw Material and Suppliers

2.2 Manufacturing Cost Structure Analysis of Anti-Senescence Therapy

2.3 Manufacturing Process Analysis of Anti-Senescence Therapy

2.4 Industry Chain Structure of Anti-Senescence Therapy

3 Development and Manufacturing Plants Analysis of Anti-Senescence Therapy

3.1 Capacity and Commercial Production Date

3.2 Global Anti-Senescence Therapy Manufacturing Plants Distribution

3.3 Major Manufacturers Technology Source and Market Position of Anti-Senescence Therapy

3.4 Recent Development and Expansion Plans

4 Key Figures of Major Manufacturers

4.1 Anti-Senescence Therapy Production and Capacity Analysis

4.2 Anti-Senescence Therapy Revenue Analysis

4.3 Anti-Senescence Therapy Price Analysis

4.4 Market Concentration Degree

Continued

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Anti-Senescence Therapy Market Growth, Sales, Trends, Supply, Forecast By 2026|Unity Biotechnology, Siwa Therapeutics, Calico LLC - Weekly Wall

Taking Care Of Your Eyes In 2020: What You Should Know – Longevity LIVE

Your eyes are one of your primary sensory gateways to the outside world. They are also one of the first things people notice about you. But while we know that the human eye can give us signals to many areas of our health, they also tend to be a part of our body we easily neglect.

Dr. Dirk J Booysen clinical optometrist, and contact-lens specialist, explains that our current lifestyle is one of the biggest dangers to eye health. People spend more time indoors, mostly doing near-work on digital devices, he says. This leads to near-point strain and can be linked to the development of myopia and astigmatism, which have taken on epidemic proportions in the Far East. Dry eye is also on the increase, and we dont have a handle on its causes yet, so treatment is difficult and chronic.

In addition, our diets have changed to suit an increasingly busy lifestyle, and obesity is the order of the day. How this affects eye health is not entirely certain, but a great deal of research is looking at dry eye, and especially myopia, to find some answers.

What we know so far from literature is that genetics play a role. If your parents are myopic, your chances of becoming myopic are greater, Booysen says.

Dry eye and asthenopia are common associations with overuse of screens, and blue light may also be harmful to the retina, adds Dr. Chrissie Cockinos, a Johannesburg ophthalmologist. Studies suggest that the increase of myopia in children may be as a result of excessive reading/digital screens too close to the eyes for extended periods of time.

Booysen says all children should have a baseline eye examination, where their risk factors can be evaluated and treatment strategies considered to prevent the myopic epidemic. Currently, there is no cure, but treatment can at least ensure that progression is slowed by up to 50%. This helps to prevent the serious pathological complications of myopia that occur later in life.

Myth 1: You can overuse your eyes

If youre afraid that your eyes might have an expiration date of some sort, rest assured; they dont. Booysen believes you should use your eyes as much as possible, keeping in mind that you need to protect them from harmful radiations such as UV and IR.

Myth 2: If you need to clean your eyes, you should use milk

You should never do this, says Cockinos. Use clean running water only.

Myth 2: Spectacles make your eyes worse

Contrary to popular belief, you wont do further damage to your eyes by wearing spectacles. However, if you need them and do not use them, you may suffer from eyestrain, headaches and fatigue.

When it comes to how your eyes react to sunlight, its quite similar to the principles of skin tone. The lighter the eye, the less pigment in the iris. This means that more light can enter the eye and potentially damage the crystalline lens and retina. As a result, notes Cockinos, people with light-colored eyes grey, light green or blue are more sensitive to bright light and glare than those with brown or dark eyes.

The pigment (melanin) in the iris works as a natural filter, which protects the internal eye, says Booysen. However, the anterior or front of the eye is not protected from the harmful rays of the sun. It needs protection in the form of a pair of good-quality sunglasses that eliminate UV light.

One of the oldest and most iron-clad rules of beauty is always to cleanse your face of makeup before going to bed no matter what. And while its mostly attributed to making sure the skin around your eyes has been taken care of, a recent case study, published in the Journal of the American Academy of Ophthalmology, indicates that this rule can help to protect your eyes as well.

According to Newsweek, in 2018 a 50-year-old Australian woman had to undergo surgery because she failed to comply with the rule. When Theresa Lynch complained to her doctor that she experienced constant irritation in her eye, her doctor found several small black spots, known as sub-conjunctival concretions. As it turns out, for about 25 years she had worn mascara every day without removing it at night. The black dots were mascara particles that had calcified under her eyelids.

Not the Tim Burton horror, but rather a description of what happens to our face when we dont get enough sleep the appearance of those pesky dark circles under the eyes. To make things worse, these come paired with puffy skin and eye bags, resulting in an exhausted look overall. These symptoms are usually due to an out-of-sync circadian rhythm, lifestyle, nutrition, or simply genetics.

For a fresher, more awake look in the skin around your eyes, the following everyday tips can help to banish these symptoms:

You probably cant start using a good eye cream or serum too early. Look for ingredients such as caffeine, antioxidants, hyaluronic acid, collagen, elastin and vitamin A, which will help to increase circulation and decrease fluid retention. For extra potency, store your cream or serum in the fridge. Dr Vale recommends dabbing it on lightly in the periorbital area. Using your ring finger is best, as this allows for the least amount of tugging on the delicate skin.

A trick we learn from supermodel Kate Moss: when you wake up, wash your face with icy water to get rid of the morning puffiness and seal the pores on your cheeks. This will get you started with brighter, awake eyes.

Once your skin is properly prepped, you can focus on concealing any remaining dark areas with makeup. Bobbi Brown, professional makeup artist and founder of Bobbi Brown Cosmetics, provides the following guidelines:

In addition to giving your skin a deep cleanse, shrinking your pores and adding hydration, the right facial can help to take care of your under-eye issues. Ask for one that gives you a gentle deep-tissue massage and stimulates the muscles under the skin. Take the facial home with a roller or a cold under-eye mask that can energize the blood flow and contour the eye area again.

The best way not to look tired is you guessed it to give your body the rest it needs. People who sleep less often have puffy, red, bloodshot eyes, says Cockinos. Your eyes lubricate properly, and old cells and proteins are cleared away by sleeping enough.

Wrinkles around your eyes are a beauty issue as old as time itself. Because the skin around the eyes is significantly thinner than that on the rest of our body, skin damage due to exposure to the sun, smoking or free radicals shows up in the form of deep, prominent crevices.

We develop crows feet due to the loss of two proteins that are needed for firm, plump skin: elastin and collagen. You can slow down and prevent premature aging in this area of your skin by:

When it comes to treatment, your options include the following:

This is still considered the most effective and long-lasting treatment for crows feet, because it prevents the muscles from contracting, and so reduces the appearance of deep lines. Dr Vale recommends treatment sessions repeated every three to four months for optimum results.

According to Dr Vale, this treatment provides the best results when the aesthetic issue is with excess upper or lower eyelid skin, as well as pockets of prolapsing eyelid fat.

This cosmetic treatment works to fill in the trough hollow under both the inside and outside of the eyes. It makes use of a dermal filler that is injected into the area under the eyes, which is usually hyaluronic acid-based. However, its important to keep in mind that this treatment needs to work around the central retinal artery. If this artery is accidentally pierced during the procedure, it could result in loss of vision or stroke. For this reason, its vital to work only with an accredited, board-certified surgeon who has the proper training for this procedure. This treatment usually lasts for between six months and a year.

These treatments can help to restore a youthful look to the skin around your eyes by removing the upper, dead layer of skin. Laser resurfacing also works to improve the production of collagen, thereby encouraging skin renewal.

Booysen advises that, for good eye health, you need to implement healthy habits. Have regular eye examinations to ensure that your eyes are healthy, and use spectacles even if your prescription is small.

In addition, you should spend enough time outdoors, and enjoy a healthy diet rich in vegetables and fruit, and low in refined sugars and carbohydrates. Click here to find out which foods can help to improve your eye health over time.

Use sunglasses (especially when youre driving), and limit the time you spend on digital devices and doing near-work.

Practice good eye hygiene, such as washing your closed eyes in the shower daily with a good eyelid shampoo. In addition, you should keep your spectacles and contact lenses up-to-date and clean.

As you reach middle or old age, you will need an annual checkup with an ophthalmologist. If you are over 50 and at risk of macular degeneration, speak to your healthcare specialist about eye vitamin supplements.

Current research will hopefully help us to eliminate or reduce the burden of common eye disease and conditions such as dry eye, macular degeneration, myopia, keratoconus, glaucoma and diabetic retinopathy. These conditions are among the leading causes of severe visual disability and blindness.

Retinal transplants in blind people have been of limited success, but researchers are still working to improve the outcomes, says Cockinos. Robot-assisted retinal procedures by expert retinal surgeons are likely to become used in the near future. Gene therapy for inherited diseases of the eye is a treatment we can look forward to. Blind people who have the means to afford a special device with a camera and external processor with a retinal chip may get minimum vision from this procedure in Germany.

Gander, K. 2018. Newsweek. Woman Who Slept In Her Mascara Every Night For 25 Years Has To Have Emergency Surgery. https://www.newsweek.com/woman-slept-wearing-mascara-surgery-remove-calcified-lumps-956185

Dana, E. 2018. Subconjunctival Mascara Deposition. Journal of the American Academy of Ophthalmology. Volume 125 (5): 641 DOI:https://doi.org/10.1016/j.ophtha.2017.12.035

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Doing business in the time of COVID-19 – CanadianManufacturing.com

March 17, 2020by Alanna Fairey, Associate Editor

PHOTO: Getty Images

Since December 2019, the world has been closely following the news of the coronavirus, and while the impact on human health has been significant, its also taking a toll on small and large companies all over the world who are planning for contingencies and trying to make sense of the virus.

According to Export Development Canada (EDC), the challenge to the global economy and Canadian exporters ultimately depends on the severity and longevity of COVID-19.

EDCs webinar, Coronavirus (COVID-19): Managing the impact on global supply chains, hosted on March 11, provided insight on how Canadian exporters can be prepared to take on the risk of doing business in rapidly changing international markets and what services EDC can offer.

Moderated by Dominique Bergevin, EDCs manager of commercial markets and small business, the panelists included vice-president and chief economist Peter Hall; senior account manager of commercial markets & small business, Amira Dali; and bank channel director, Rajesh Prashadcolah.

With COVID-19 impacting the global supply chain, Hall stressed that it is important for businesses to have contingency plans in place for key suppliers for liability purposes.

This may include reviewing some of the existing terms and conditions with your customers, your suppliers and ensuring that the language will protect you from future events, Hall said.

When it comes to suppliers, most people think both companies are providing you the raw materials are equipped to ensure operation, but a key supplier can also be your banker advisors.

Added Hall: Its important to have these conversations with their partners in advance.

While the significant decrease in numbers has many feeling fearful of a recession, Hall said that this will not be the reality in the long-term.

The key message here is that there is a limit to the duress, and there is a limit to duration and thats not what the popular medium is generally playing on my channel. Its very much about fear, Hall said.

For her part, Dali stressed that it is important to have risk management systems that encourage businesses to be proactive rather than reactive to the hurdles that COVID-19 is imposing.

Risk management strategies should be made of four segments which include: risk avoidance, risk sharing, risk reduction and risk transfer.

Dali also said that is essential for exporters to have insurance plans set up and to have conversations with financial partners prior to a pandemic to understand what financing options are best available.

No matter what industry that youre in, theres a resource available out there, starting with your trades and missionaries, Dali advised. The Trade Commissioner Service is a great starting point, whether locally or whether internationally.

While the repercussions of COVID-19 were events that could not have been foreseen, Hall concluded the webinar by reminding viewers that the experiences of COVID-19 can help them make plans for their business and their third parties moving forward.

Having contingency plans in place for key suppliers and customers will help mitigate some of that and this may include reviewing some of the existing terms and conditions with your customers, your suppliers and ensuring that the language they will protect you from future events, Hall said.

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Cancer in Dogs and Humans: How is it alike and how is it different? – Open Access Government

Cancer recently passed cardiovascular disease to become the leading cause of human mortality across much of the industrialised world. Cancer is widely believed to be the leading cause of disease-related mortality in dogs as well. On the surface, it would be easy to assume this shared and tragic cancer epidemic in humans and dogs was a dark side of industrialisation and modernisation. After all, in much of the developed world, dogs have become integral members of human family units, living with humans in a common environment, sharing histories of lifestyle, nutrition, and environmental exposures.

Although the most common cancers in humans and dogs are different, the idea of a common origin is bolstered by the similar physical and microscopic appearance of tumors that form in the same anatomic locations as well as by the comparable clinical course of these diseases in both species. These similarities have positioned spontaneous cancers of dogs as unique models that can be used to better understand the origin and progression of human cancers and to develop safe and effective treatments.

The comparative oncology approach has yielded many interesting findings, including that the shared reality of cancer in humans and dogs is more complicated than exposure risks associated with modernisation. To understand the cancer epidemic, we must travel far back in time to the emergence of multicellularity. The fossil record documents cancer in animals for hundreds of millions of years. For example, a bone tumor recently identified in a 240-million-year-old turtle fossil supports the occurrence of cancer throughout evolution. This finding is by no means unique and it is probably not the oldest.

Today, cancer accounts for about 5% of deaths in almost every animal species. In the context of evolution, species adapt to a balance of resources, consumption, and lifespan over millions of years. Long-lived species such as whales, elephants, Amazon parrots, great white sharks, and naked mole rats, among others, acquired unique cancer-protective mechanisms: molecular safeguards that allow for innumerable cell divisions while reducing the probability of mutations that are necessary to initiate cancer. Over millions of years, these adaptive, cancer-protective solutions became inexorably linked to the expected lifespan of that species, and the adaptations seem to be as varied as there are species.

Dogs and humans were similarly subject to this selection over most of their evolutionary history. The dog family, for example, split from its last common ancestor about 6 million years ago, and our direct human ancestors split from other hominids approximately 2 million years ago. As they adapted to their respective biological niches, dogs developed an expected lifespan of 2 to 4 years and humans developed an expected lifespan of about 30 to 40 years. Infection, injury, and malnutrition were the most common causes of death for dogs, and infections, inter-human aggression, and accidents were the most common causes of death in ancestral humans.

At present, cancer accounts for about 5% of deaths in people up to the age of 35 and in dogs up to the age of 3 to 4 in developed countries, similar to the overall cancer mortality in the majority of other species. Beyond those evolutionarily-determined lifespan thresholds, the cancer risk increases several fold in people and in dogs. Over the past 200 years for humans and the past 50 years for dogs, the availability of health care, nutrition, energy, social protection, and other such modern changes have reduced overall mortality and expanded life expectancies. This has allowed people to live to about 80 years of age (twice our evolutionarily-determined lifespan) and for dogs to live to about 10 to 12 years of age (almost three times their evolutionarily-determined lifespan). Humans and dogs have no mechanisms that can protect their cells from the effects of mutations that occur over these newly expanded lifespans.

To add insult to injury, in both species, but especially in companion dogs, natural selection has been almost completely replaced by artificial selection. There are few natural selective pressures to guide evolution of cancer-protective mechanisms to support our long lifespan. The consequences are obvious. Shattering the evolutionary barriers of longevity without compensatory cancer-protective mechanisms makes dogs and humans increasingly vulnerable.

In all, there are about 700 genes in our genomes where mutations that alter function can promote cancer. We do not fully understand the interactions that occur among the products of these genes, or between these cancer-causing genes and the rest of our genome. But with few exceptions, the catalog of specific mutant genes in tumors arising from the same cell types or tissues in humans and dogs are vastly different. And yet, the molecular programs that characterise these homologous tumors are remarkably similar.

This raises important implications with regards to our efforts to learn from cancers across species. We must account for the glaring differences in causation while continuing our focus on commonalities. Dogs can teach us how expanded longevity overcomes a species cancer-protective mechanisms. Moreover, comparative approaches can help us to understand how constraints on the organisation of tumors into specific structures create vulnerabilities that we can exploit to attack or prevent cancer in both species.

Finally, cancer is not inevitable. Even with the risks of replication-induced mutations and longevity, only about 1/4th to 1/3rd of all humans and dogs are expected to develop cancer in their lifetime. It is a bit of a Russian roulette.

Incredible breakthroughs have been made in treatments for advanced human cancers, which raises hope for future applications in dogs. Still, the pace of research and progress is slow, and with cancer overtaking all other causes of death in both humans and dogs, alternative solutions are necessary. This has guided our recent efforts to develop robust diagnostic tests that identify cancer signatures before tumors form, paired with interventions that eliminate nascent malignancies. The benefits of a comparative, wholistic approach to guide this process are undeniable. We are convinced that these preventative strategies and others like them will be part of the solution to cancer. We are also convinced that comparative oncology approaches are necessary to continue progress for all species.

Acknowledgments: The author gratefully acknowledges Dr. Michelle Ritt and Dr. Michael Henson for their helpful discussions and suggestions.

Please note: This is a commercial profile

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Coronavirus: Can Increase In Temperature Kill COVID-19? Experts Weigh In – NDTV News

Temperatures Impact on COVID-19: Experts have varying views on whether heat can limit growth of the virus

Coronavirus: COVID-19 virus has now spread across over 110 countries with no known vaccine or cure. There has been a conjecture that increased temperature can kill the virus and that the onset of summer will lead to a breakdown in transmission of the virus. However, scientists do not have a definite answer on the influence of summertime temperatures on COVID-19, says Dr Laxman Jessani, Consultant, Infectious Diseases, Apollo Hospitals, Navi Mumbai.

He goes on to add: It has been observed that the virus can stay active for 8-10 days on dry surfaces and while it survives in the human body at 37 degree Celsius, they are heat labile like all viruses and are deactivated or destroyed when subjected to heat. However, the exact threshold temperature to deactivate COVID-19 is still unknown.

Around the world, while different experts have varying views on whether sunlight and heat can limit growth and longevity of the virus, they all agree that observing proper hygiene is more effective in preventing spread. However, the coronavirus is known to be sensitive to three things: Sunlight, High temperature, and Humidity. Sunlight affects the ability of a virus to grow while heat deactivates it.

Also read:Coronavirus Vs Flu: How To Spot The Difference? Know The Exact Symptoms

While experts debate on this matter, summer is still a month away and till then it would be prudent to adopt simple measures to help prevent transmission:

Washing hands regularly is an important prevention step for coronavirusPhoto Credit: iStock

Also read:Coronavirus: Our Expert Shares 7 Tips To Make Your Kids' Time Productive Amidst Shutdown Of Schools

Dr P. Raghu Ram, President of The Association of Surgeons of India, has a contrasting view on this. He says, "If this was the case then incidence of coronavirus in countries like Australia and Singapore should have been low. There is still a lot that we need to know about the novel coronavirus."

He goes on to add that even in the opinion of World Health Organization, we should not be relying on warmer temperatures to come and put an end to coronavirus outbreak.

Also read:Coronavirus: Your Queries Answered By Experts

(Dr Laxman Jessani is Consultant, Infectious Diseases, Apollo Hospitals, Navi Mumbai)

(Dr P. Raghu Ram is President of The Association of Surgeons of India)

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

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How you can help in fighting coronavirus using your Mac: Read to find out. – Gizmo Posts 24

[emailprotected] is a computing project that stimulates protein folding, computational drug design, and various other molecular dynamics for disease research. It tackles diseases like cancer, Alzheimers, Huntingtons, and Parkinsons. It has announced that now it will deal with COVID-19 as well.

The project is bringing together researchers worldwide who aim to understand the coronavirus better. This will speed up the effort going to developing therapies and cures that will save lives.

You can download [emailprotected] on your Mac. By doing this, you can donate the computational resources that you havent used to the [emailprotected] Consortium. Here, researchers are attempting to examine the structures of drugs that could potentially help in the new therapies for COVID-19.

Prior to installing [emailprotected], you need to know that it can use up a lot of CPU cycles. Thus, it is advisable that you run it only when your Mac is sitting idle.

To see the visual representation of the whichever molecules your Mac at that time, you can click the Viewer button.

Since this process takes up a lot of power, if you switch your laptop to battery power, the [emailprotected] client will automatically pause. You can change this setting as well by going to Configure Advanced Power.

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How you can help in fighting coronavirus using your Mac: Read to find out. - Gizmo Posts 24

PC gamers and researchers asked to donate GPU and CPU time to help fight coronavirus – www.computing.co.uk

PC gamers and researchers asked to donate GPU and CPU time to help fight Coronavirus

A distributed computing project is urging researchers and PC gamers worldwide to donate some of their CPU and GPU computing power to help in the fight against coronavirus, also known as COVID-19.

Folding@home (FAH) is an international project based in the Pande Lab at Stanford University. Led by Dr Greg Bowman, the project utilises the idle computing power of hundreds of thousands of PCs owned by volunteers across the world to simulate the molecular dynamics of protein folding and misfolding in various diseases.

According to FAH, those simulations will help scientists in discovering new drug opportunities against diseases.

Please be patient with us! There is a lot of valuable science to be done

The FAH team is currently aiming to investigate how specific proteins in the novel coronavirus (COVID-19) operate and how those proteins can be destroyed to prevent the virus from multiplying within the human body.

Last month, the FAH team announced that it was taking up the fight again coronavirus, with the aim to help develop a therapeutic antibody, similar to that previously developed for SARS-Cov in 2003.

"To help tackle coronavirus, we want to understand how these viral proteins work and how we can design therapeutics to stop them," FAH said.

The deadly coronavirus has already killed more over 6,300 people worldwide, while hundreds of thousands still remain infected with the virus. Governments across the world are responding to coronavirus outbreak by curbing the movements of citizens and tightening borders.

FAH has so far added 23 coronavirus projects to use donated GPU or CPU power to study the coronavirus.

Contributing to the FAH project is easy, as users just need to download and install the client for their operating system from the FAH website. Once installed, the client will be configured to 'lightly' use system's GPU and CPU processing power to perform protein simulations.

Users can also use 'Medium' or 'Full' options to increase the amount of CPU and GPU utilisation.

"Usually, your computer will never be idle, but we've had such an enthusiastic response to our COVID-19 work that you will see some intermittent downtime as we sprint to setup more simulations," FIH said.

"Please be patient with us! There is a lot of valuable science to be done, and we're getting it running as quickly as we can."

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How to Help the Fight Against Coronavirus From the Safety of Your Own Home – ExtremeTech

This site may earn affiliate commissions from the links on this page. Terms of use.

One of the difficulties with dealing with a pandemic is that successfully battling the contagion can require taking actions that are diametrically opposed to what our own instincts want to do: Namely, to do something either to protect ourselves or to protect those we care about. All of this is in direct contradiction to best medical practices, which calls for people to adopt social distancing techniques to the maximum extent possible.

There is, however, something you can do to help fight SARS-CoV-2, the coronavirus that causes the infection known as Covid-19: Contribute to Folding@Home. By downloading and installing the Folding@Home client, you can donate your spare CPU and GPU cycles to working on modeling. The Folding@Home team has made several blog posts from their efforts. The project was first explained in a Feb 23 post:

For both coronaviruses, the first step of infection occurs in the lungs, when a protein on the surface of the virus binds to a receptor protein on a lung cell. A therapeutic antibody is a type of protein that can block the viral protein from binding to its receptor, therefore preventing the virus from infecting the lung cell. A therapeutic antibody has already been developed for SARS-CoV, but to develop therapeutic antibodies or small molecules for 2019-nCoV, scientists need to better understand the structure of the viral spike protein and how it binds to the human ACE2 receptor required for viral entry into human cells.

The other coronavirus mentioned is SARS and 2019-nCoV was the old term for the virus now referred to as SARS-CoV-2. They continue:

Proteins are not stagnantthey wiggle and fold and unfold to take on numerous shapes. We need to study not only one shape of the viral spike protein, but all the ways the protein wiggles and folds into alternative shapes in order to best understand how it interacts with the ACE2 receptor, so that an antibody can be designed. Low-resolution structures of the SARS-CoV spike protein exist and we know the mutations that differ between SARS-CoV and 2019-nCoV. Given this information, we are uniquely positioned to help model the structure of the 2019-nCoV spike protein and identify sites that can be targeted by a therapeutic antibody. We can build computational models that accomplish this goal, but it takes a lot of computing power.

And the truth is? The combined computing power of human nerddom is capable of delivering performance that would blow Summit out of the water, though how much of it Folding@Home could practically leverage would be something of a question. Its true that the speed of any single commodity system is going to be slow in comparison to the challenge. The speed of all of our commodity hardware, on the other hand, might actually make a difference.

In an updated blog post from March 10, John Chodera writes:

Folding@home team has released an initial wave of projects simulating potentially druggable protein targets from SARS-CoV-2 (the virus that causes COVID-19) and the related SARS-CoV virus (for which more structural data is available) into full production on Folding@home This initial wave of projects focuses on better understanding how these coronaviruses interact with the human ACE2 receptor required for viral entry into human host cells, and how researchers might be able to interfere with them through the design of new therapeutic antibodies or small molecules that might disrupt their interaction.

The goal of the Folding@Home project is to target the most promising drug targets to find alternate conformations or hidden pockets the sort that you can only find in simulation. Basically, Folding@Home wants to take the most likely candidates and then examine them with a fine-toothed comb to make sure no stone goes unturned. Download and install FAH, and youll be asked if you want to mine anonymously or for a team. If you dont care about the entire team thing, you can just hit Anonymous. The application devotes to a web interface, but you can activate a desktop Advanced Control panel just by searching for Folding.

The basic control panel. Ive only just started my own system mining again, after 15 years or so away.

Any is the default setting here, and its the right one. There isnt a specific allocation for Coronavirus yet. From the tone of the blog posts, it sounds as if work on SARS-CoV-2 is still ramping up. No, contributing to a distributed computing project isnt going to magically make a solution appear out of thin air but we might make a difference to how long it takes to find a cure the scientific way. Ill be bringing some testbeds online towards this purpose. Hope youll join me.

Oh. And please wash your hands.

Top image by NIAID-RML/CC BY SA 2.0

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Microsoft, Zuckerberg and Allen team up to use AI in the fight against coronavirus and are challenging other – Business Insider India

The initiative includes Microsoft Research, the Allen Institute for AI founded by Microsoft co-founder Paul Allen and the Chan Zuckerberg Initiative, set up by Facebook founder Mark Zuckerberg and his wife Priscilla Chan.

The entire database will be updated on a weekly basis, adding new research from peer-reviewed journals and other archival services. In order to motivate researchers to take the challenge head-on, Kaggle is hosting the Covid-19 Open Research Dataset Challenge (CORD-19).

All hands on deckThe actual papers are provided by the National Institute of Healths National Library of Medicine. Its also linked to the World Health Organisations (WHO) database of publications on coronavirus. The project is being coordinated by Georgetown Universitys Center for Security and Emerging Technology (CSET).

Even though the database was requested by the White Houses Office of Science and Technology Policy anyone from around the world harness the information to make their own deductions.

With this step, weve made available full-text, machine-readable resources to help speed response to this global crisis, said Dewey Murdick, CSETs director of data science.

Another tech company called Fold@Home is distributing a computing project online that helps users and contributors conduct research on Covid-19 by simulating molecular dynamics. Researchers can simulate processes like protein folding and drug design to understand how the coronavirus would react.

As of today, there are over 165,000 confirmed cases of the coronavirus worldwide across 146 countries with 126 people infected in India.

See also:Coronavirus recovery rate at 54% as doctors race to find a cure

Coronavirus pandemic: Bill Gates warned us that this day would come five years ago

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Nvidia’s calling on gaming PC owners to put their systems to work fighting COVID-19 – GamesRadar+ UK

If you have a gaming PC, you can lend your graphical power to fighting the COVID-19 outbreak. That's not a thing I ever thought I'd write, but it turns out 2020 is occasionally weird in good ways too.

Nvidia is putting out a call to PC gamers everywhere to download the Folding@home application and start putting their spare clock cycles toward advancing humanity's scientific knowledge of coronavirus. The program links computers into an international network that uses distributed processing power to chew through massive computing tasks - something that gaming-grade GPUs are quite good at, as it turns out. You can still turn the application off and reclaim your GPU's full power for playing games whenever you want.

Folding@home has been around for years - it was also available on PS3 back in the day - with users lending their distributed power to all kinds of research. A new wave of projects "simulating potentially druggable protein targets from SARS-CoV-2 (the virus that causes COVID-19) and the related SARS-CoV virus (for which more structural data is available)" were made available on the service earlier this week.

These projects could help researchers better understand coronavirus, and eventually even develop effective therapies against it. If you've been grappling with feelings of helplessness in the face of the worldwide outbreak, this is a small but real way you can lend your aid to the world without any medical experience. It also doesn't hurt that you don't need to leave your house to do it, since we're supposed to avoid that as much as possible anyway.

Pokemon Go is making some changes to help players keep enjoying the game while allowing for social distancing. Staying at home this weekend? Maybe you need a Disney Plus bundle to pass the time. Or if you've been thinking of upgrading your gaming PC check out our picks for the best graphics cards or best gaming laptops.

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Everything Natural Expo exposes visitors to healthy living – The Abington Journal

March 10, 2020

Pennsylvania Department of Transportation officials were present at the monthly ACOG (Abington Council of Governments) meeting on March 5 at which area projects were discussed.

Rich Roman, district executive for PennDOT District 4, began by telling ACOG members that the staff of PennDOT will answer questions they may have. He said that PennDOT is challenging the new employees to step up in their positions.

Im really positive and hopeful and really looking forward to what the next decade of District 4 will be, he said. Roman said PennDOT will be working on about 66 projects this year including highways and bridges, He encouraged anyone from ACOG to comment or ask questions.

Clarks Summit Councilwoman Gerrie Carey told Roman how the old stormwater pipes are caving on Grove Street . She said that boroughs and townships are under different rulings.

If it was a township, the state would come in and take care of it, she said. But when its a borough, they dont.

Roman replied that there are different laws that govern drainage depending on the boroughs or townships. We have to follow whats in the law, he said.

Roman said that in townships, PennDOT bears the responsibility and in the boroughs, its up to the boroughs. He recalls when he worked in a different position in Harrisburg, the population centers of the state were different.

We try to find ways to partner and to do things, he said. And I know were doing some things with Clarks Green as far as it relates to a maintenance agreement, but its tough when you see those aging systems starting to fail, and our hands are tied as well.

Carey asked if there are any grants in which ACOG can apply for. Roman said that grants are competitive and would need a good grant writer. He also said that the resources are scarce.

ACOG recording secretary Marnie Palmer asked why there arent prisoners clearing Interstate 81. Roman said that the Department of Corrections dont want prisoners cleaning litter since it doesnt teach them life skills they need after getting out of prison.

He said a campaign is needed so that people arent littering.

We ask out counties usually in the summer every two weeks to try to come through a pick-up or something but the next day, it looks like you dont do anything, he said.

Dalton Councilwoman Elizabeth Bonczar asked who enforces littering laws. Roman answered that someone cant be cited unless a trooper sees that person litter. Charles Wrobel, of Factoryville Borough Council, suggested more signage.

Pennsylvania does not have the sign I see in other states, he said.

Bonczar asked Roman how to acquire speed sentry signs for Dalton. Roman replied that by saying she can send a letter to PennDOT, and they will ask the traffic engineer. Chris Goetz, municipal services engineer, then said that boroughs have the option to purchase their own signs which collect data.

Roman announced that work zones across the state will have photo enforcement. He said that when someone exceeds the sped limit, a camera will take a picture of that persons license plate. He said that the citation will be sent to the owner of that car. Your first offense is a warning, he said. The second offense is $75. The third offense and thereafter is 150 (dollars). Roman said that this system is in participation with the state police and the PA Turnpike. He assured that it isnt made to make PennDOT money but to have drivers slow down and prevent crashes. He said that in 2018, 23 people died in work zones. Susan Hazelton, assistant district executive of PennDOT, handed out schedules with upcoming District 4 projects such as the resurfacing on State Route 1027 (Layton Road) from State Route 11 (Northern Blvd) to State Route 632 (Commerce Road). This (schedule) might change just a little bit as we can go on and a little bit at a time, she said to ACOG. We can get you an update yearly (or) however you want to see that update.

Rick Williams, of Clarks Green, expressed concerns about two intersections both on Abington Road. He said that the intersections of Highland Ave. and Abington Road and Fairview Road and Abington Road cause congestion both day and night. He said that when ACOG began twenty years ago, one of the first major projects was to have a traffic study by PennDOT. He said that when he was a councilman, he applied for a 10-year program, in which Council had to reapply every two years. He said that during the fourth year, he left Council.

I checked in year six, and our secretary and council president had renewed the request, he said. I checked again in year eight, and they had dropped the ball. And all that work was lost, so nothing ever happened to Abington Road.

Williams asked PennDOT how to get back in this project. Hazelton said that a potential traffic signal would help the intersections. Williams said that Council cant afford a signal. She then advised Williams to write a letter, which would go to PennDOTs transportation planning organization.

ACOG president Dennis Macheska praised PennDOT for their work with the townships over the years.

PennDOT has been good to us, he said. And we are good to PennDOT.

Macheska said that this year, Ransom Twp is repairing two roads Community Drive and Beacon Drive. He mentioned that Ransom is taking the money for this out of their budget, not the liquid fuels fund.

Joyce Hatala, representing Benton Twp, praised PennDOT for working with her to renovate the bridge on Baylors Lake. She said that she tried to get the bridge onto the National Register of Historical Places. I know its eligible, she said.

Roman said that if anyone has any more questions, they can contact PennDOT.

In other business, Hatala, who is a Pennsylvajia master watershed steward for Penn State Extension, will speak about a homeowners guide to stormwater to prevent stormwater runoff in their property and to improve water quality and correct planting. She will speak about this during the regular monthly ACOG meeting on Thursday, May 7.

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Tips for getting healthy in the workplace – The Oakland Press

More than ever, companies recognize the need to support employees on and off the clock. In fact, about half of employers offer some type of health promotion or well-being program. Its a nationwide effort proven to increase productivity, improve morale and boost employee retention. The average person spends one-third of their life on the job, making these programs a valuable investment in their long-term success.

Every workplace is different so creating a successful wellness program depends on employees health goals and areas of interest. From quitting smoking to financial planning, establishing promotion programs can reduce health care costs and absenteeism among staff. Here are some examples:

Gym discounts: Employers can encourage people to be physically active with corporate discounts at participating gyms or fitness clubs. They can also provide incentives through a healthy living program, which may monitor weight, tobacco use, blood pressure, cholesterol or blood sugar.

Online resources: Employers may also suggest employees create an online account with their health insurance company to utilize wellness resources. This includes free health assessments, symptom checkers, medical records, fitness trackers and even recipes.

Seminars: Some employers provide virtual seminars with experts to promote lifelong learning. Through financial planning, mindfulness, meditation and gratitude, employees are empowered to take control of every aspect of their well-being.

Tobacco cessation coaching: It isnt easy to stop smoking. It takes personal, and in some cases, professional support. Employers can partner with outside organizations to provide coaching and mentoring for employees eager to break the habit.

Not every employer can offer a full spectrum of well-being programs. But there are ways employees can make healthier choices that have a similar impact. Over time, the following actions can lead to big, life-changing results:

Drink more water: Water is more than 50% of the bodys composition and is integral to maintaining good health. It helps flush out of toxins, removing waste and other harmful elements. Staying hydrated is also a simple way to combat fatigue, manage weight and improve focus.

Find an accountability partner: Coworkers who share similar health goals can create their own support system. Friendly step competitions, weekly check-ins and ongoing conversations about workplace wellness can keep them accountable and help to maintain healthy habits.

Pack a lunch: By preparing their own meals, employees have power over food portions. This also helps to limit or avoid ingredients that may be detrimental to their goals. In addition, bringing healthy snacks to work can also curb cravings or lingering hunger.

Step away from the chair: Workplace meetings dont have to be stationary. Just three hours of continuous sitting can cause poor circulation and vascular damage. Consider taking a walk during conference calls. Using this time to stretch can help prevent blood clots, arterial strain and sudden stiffness.

Cindy Bjorkquist is the director of well-being programs at Blue Cross Blue Shield of Michigan. For more health tips, visit MIBluesPerspectives.com.

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Tips for getting healthy in the workplace - The Oakland Press

Float therapy helping many to rest, rejuvenate | Healthy Living – Uniontown Herald Standard

When Jeff Jalbrizikowski was in Chicago for a work conference recently, he searched for, and found, a float therapy spa.

About 10 months ago, Jalbrizikowski, 37, of Pittsburgh, incorporated float therapy into his self-care routine.

At least once a month, the U.S. Army veteran who served in Iraq and Afghanistan, and is an avid cyclist and runner, floats in total darkness and silence in an egg-shaped tank filled with Epsom salt at True REST Float Spa in Scott Township.

At first, it was pretty weird, but within five minutes of my first time there, I smiled. I had a big grin of my face, said Jalbrizikowski. I was just able to relax. It wasnt some miraculous cure, but floating gives me a chance to get super relaxed. Its given me a mindset that its OK to relax.

Once considered a fad embraced by hippies, floating is gaining respect as a wellness practice and is becoming more mainstream.

Float therapy, or REST (Restricted Environmental Stimulation Therapy), has been embraced by athletes in many sports - including NFL, NBA and MLB players, marathoners and Olympic athletes - who tout physical and mental benefits theyve experienced, such as quicker recovery time, improved mental visualization and better sleep.

Nate Apland, manager of the Scott Township True REST Float Spa said Pittsburgh Steelers, American Ninja warriors, University of Pittsburgh Panthers and other athletes have floated there, and the company that installed True RESTs pods also installed one in New England Patriots quarterback Tom Bradys home.

But athletes arent the only people who float. Apland said floaters come in all ages and come for a variety of reasons: easing chronic pain, to increase circulation and reduce stress and anxiety.

Floating helps with a lot of things. Theres a physical and mental benefit, said Apland, a former exercise physiologist. The pod kind of gives you what you need. Its a great environment because there are no distractions, no cell phones going off. We are being over-stimulated nonstop today, and thats a huge reason why youre seeing people with anxiety and stress. The hour that youre here is an hour where youre shutting off the stimulation to your brain. We say, jokingly, that its a mental and a physical re-set.

True REST offers eight suites, complete with a changing area, rainfall shower, earplugs, petroleum jelly (to cover cuts that might be irritated during the float) and a tub filled with 10 inches of water and about 1,200 pounds of Epsom salt. The salt content is about 30%, making it twice as buoyant as the Dead Sea and enabling the body to float.

There are no pressure points on the body when its floating.

The magnesium in the water, Apland said, helps reduce inflammation and leaves skin smooth.

Floaters have the option to keep the lights off, or select one of several colors in the tub. They also can listen to music piped in through a speaker in the tub, bring their own music, or float in silence.

Apland said a majority of clients float with the lights off.

The pod can be closed completely, or left open.

After the float, clients are provided with tea or water, and have access to an oxygen bar that offers 94% pure oxygen that is run through distilled water infused with plant-based essential oils.

Floating was invented in the mid 1950s by neuroscientist Dr. John Lilly, who began experimenting with the minds response to sensory deprivation. Participants in his study were placed into a flotation chamber Lilly built, and when they emerged, they reported feelings of intense relaxation and calm.

Apland cited an MRI study conducted by Dr. Justin Feinstein, a neuropsychologist and director of the Float Clinic and Research Center at the Laureate Institute for Brain Research in Tulsa, Okla., that determined floating shuts down the amygdala, the area of the brain that triggers the fight-or-flight response.

Thats important for people with PTSD, anxiety and stress because it actually reduces stress in a way that medication and prescription drugs do, without the side effects, said Apland, who noted True REST offers free floats to military veterans, active military personnel, and first responders once a month.

By the early 2000s, interest in float therapy - which went out of favor in the 1980s - rekindled. In 2009, less than two dozen float spas operated. Now, there are hundreds.

Thats welcome news for Jalbrizikowski, a land surveyor who travels often.

Float therapy has helped him improve physically and mentally, he said. In the past year, he has dropped 35 pounds, has recovered from sports injuries and has noticed an improved mood.

Again, its not magic, but its been good for me, mentally, and I feel like Ive been able to get back to cycling and running because Ive healed from the injuries Ive suffered. Ive been pleased with myself in 2019, said Jalbrizikowski. Somehow, its helped.

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Float therapy helping many to rest, rejuvenate | Healthy Living - Uniontown Herald Standard

Forum: Add reward, incentive element in healthy living push – The Straits Times

Giving Singaporeans aged 65 and above free entry into public gyms and swimming pools is a good move by the Government (Keep free entry to gyms, pools for seniors to off-peak hours, by Mr Nigel Marcus Ong Chin Hock, March 14).

Other than fine-tuning details on peak and non-peak hours of entry, the Government should consider adding some kind of incentives to make the policy more comprehensive and results-oriented.

The aim should not only be to encourage younger Singaporeans to have healthy lifestyles during their prime, but also to have something for them to look forward to by keeping fit and not being couch potatoes.

Equally important is that a healthy populace will mean less of a demand and strain on the nation's medical facilities.

Instead of allocating funds to build one public hospital after another, it is far better and less costly to build and maintain facilities to encourage healthy lifestyles that will translate into better productivity and even a bigger gross domestic product.

On the flip side, Singaporeans who have not paid attention to what they consume and how they live before reaching age 65, will not gain much from the free entry into public gyms and pools.

By then, some may not be able to enjoy the concession as they are already in poor health.

The incentive element is more vital to spur Singaporeans to be responsible, live well and stay healthy for their own good and for their families.

Between the two, free-entry concession versus incentive, the latter aspect has both the prevention and reward features.

Tan Kok Tim

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Forum: Add reward, incentive element in healthy living push - The Straits Times

Healthy living, not expensive creams makes skin glow – Free Malaysia Today

Being fit and eating right are key to having healthy-looking skin, researchers say. (Rawpixel pic)

ST ANDREWS: New UK research has found that if you want to achieve a natural glow, then a healthy lifestyle with exercise, enough sleep, and not too much stress can all add a healthy, golden tone to your skin.

Previous research has already linked a healthy diet high in fruit and vegetables to skin yellowness, which the researchers say is an indicator of health, as fruit and veggies are packed with antioxidant-coloured pigments called carotenoids, such as orange carotene from carrots and red lycopene from tomatoes.

These coloured pigments then accumulate in the skin, giving it a yellow tone which can indicate good health as it suggests that a persons body has enough antioxidants and low levels of oxidative toxins.

However, for the new study, led by the University of St Andrews, the researchers wanted to look at the link between skin yellowness and exercise.

To do this, the team recruited 134 university students of various ethnicities, and measured their skin colour using a spectrophotometer, which records illumination and the rainbow of colours reflected from the skin.

The participants also had their heart rate measured while walking and running on a treadmill to assess their fitness levels and had their body fat levels recorded.

The findings, published in the journal Frontiers in Psychology, showed that both a high level of fitness and low body fat were associated with a higher skin yellowness, which makes the skin look healthier and more attractive.

The team say that the yellower skin was not due to a suntan or even diet.

Instead, they believe that exercise could boost the bodys own antioxidant systems, and so instead of needing to use up the carotenoid pigments which one ingests from their diet, they are free to accumulate in the skin, giving people a yellow tone.

To investigate further, the researchers then looked at whether experiencing a change in health would also result in a change in skin appearance.

After following 59 students who were members of sports clubs, the researchers found that an increase in fitness or losing body fat were both linked with an increase in skin yellowness.

On the other hand, an increase in stress and not getting enough sleep were both associated with a reduction in skin yellowness.

Once again, the researchers say changes in skin colour were not due to suntan or from training outdoors.

The team say the findings now suggest that in addition to eating plenty of fruit and vegetables, and other healthy lifestyle factors such as exercising, losing excess body fat, reducing stress and getting enough sleep could all boost skin colour.

As skin colour is also linked to attractiveness, they added that this could help motivate people to follow a healthier lifestyle.

Lead scientist for the study, Professor David Perrett, also added that, We were surprised to find that the skin colour changes accompanying change in health occurred quite quickly and within eight weeks.

This means that any effort to improve lifestyle will benefit appearance within a relatively short time.

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Healthy living, not expensive creams makes skin glow - Free Malaysia Today

Sleeve Into Altered Carbon: The Role Playing Game – Nerdist

Based on the 2002 novel Altered Carbon, the self-proclaimed neo-noir cyberpunk series is expanding into a tabletop roleplaying game. The Netflix show just launched its second season. Combining a healthy mix of Bladerunner, Total Recall, and Transhumanismthe setting rocks as an RPG. Apparently, the Kickstarter did too, raising over 1000% of their funding goal and hitting over 3,900 backers by the end of its run. Hunters Entertainment (Outbreak: Undead) headed up the design with an amazing team of people, so its no surprise that this Kickstarter slew expectations.

The Kickstarter page contains the vital information any prospective player could need. We still wanted to take a moment to highlight some things that are unique to a world in which you cant die. Imagine the prospects for a moment. Villains can be killed only to return later, potentially wearing the face of the partys friends. A full TPK can happen, and the adventure continues with the consequences of that folly. Or bar fights suddenly become far more bone-breaking. Not only does this concept present interesting ideas for storytelling but Altered Carbon RPG is also flipping our dice on us.

Using the Hazard system, the game encourages you to roll natural 1s. Which is frankly, glorious blasphemy. I think this gameplay difference is important to differentiate the setting and game for long term roleplaying game players. If youve been rolling D20s for a while, changing the dice mechanics on your table does work as a tangible reminder of the new world.

For as long as Ive been a storyteller; Ive often been running Cyberpunk, Transhumanism, or modern settings as long-term campaigns. I love high-tension, cheeky, dystopian conspiracy games so naturally Altered Carbon stole my interest. But every group needs one person to take up the mantle of Gamemaster. Lets take a look at how two major aspects of storytelling in a Transhuman or Cyberpunk setting in order to inspire other storytellers!

In this transhumanist world, the human mind is Digital Human Freight. Stored in a small, diamond-hard device at the base of the skull, everyone calls a cortical stack it. Some people have their brains sliced and scanned in layer-by-layer while others take a more digital approach. The end result is the same: you can re-sleeve your entire consciousness into a new body. With remote digital back-ups, needle casting your mind to other planets, or having a variety of custom bodies on handyou can become an immortal god. The ability to change bodies or sculpt your frame like an automobile is a dream for many.

Permanent death is possible for anyone whose stack is destroyed, but namely, you focus on an uplifting style of storytelling. Re: The characters backstories. Create elaborate backstories with wonderfully fleshed-out characters with full narratives by spending time with your players. The concept of a session zero is infinitely more important in settings like AC. Once created, weave those delicious backstories together into one yarn-ball of a plot. Since characters can be hundreds of years old, its okay to hop a few decades. Long-term gameplay in a transhumanist setting isnt going to be about TPKs, rather, about the parties choices around that ball of yarn. Some threads will get tugged, others will get knotted, and at least one will be hacked with a chainsaw. Meanwhile, villains at the beginning of the game can become allies later on. Only to swap sides again later. Embrace this fluidity as a storyteller.

Since the characters and NPCs will remain under the campaign spotlight for a long time, time invested into them is well spent. This also opens several new tactical options for both sides of that storyteller screen. For example, if the party knows they will resleeve they might consider one-way-ticket missions with no extraction. Nothing says a salty faction cant strike at the partys prized bar in the same way.

Cyberpunk worlds are both storytelling gold and a daunting task of finding where to start. Altered Carbon gives us a major campaign focal point called Bay City. Focused into three, easy to identify, and easy to dabble in factions: The Ground, the Twilight, and the Aerium. Poor, middle, and methuselah godlike rich respectively. Narrowing down a multi-planet cyberpunk setting to former San Francisco is exactly what gamemasters need to focus on a campaign. I couldnt be happier with the QuickStart guide for doing exactly that, and I really want to give a special shout out to the designers for making that call.

Well done chaps.

To prevent getting lost, shine a spotlight on local beats. Basically, in a setting with billions of people teeming on top of each other location bloat can be a major design problem. Its easy to fall into the pit of infinite information, and your players suffer from the noise. Cities are nearly infinite in story, filled with vast sprawling segments, and can make the PCs feel tiny. Unlike fantasy campaigns, the pulse of an urban fantasy or cyberpunk campaign beats inherently different. Less territory control or nation wars, and more investigation and fights containedjust out of sight.

Keeping everything setting wise sorted into factions or companies creates instant bonding with players. The Meths and the Grounders are easy factions to grasp onto and weave into a story. For added flair, toss in some company products and branding on your player characters weapons and youve seeded your immersion. Instead of having named NPCs, simply use faction representatives. If a pair or duo of them keeps recurring, feel free to start fleshing them out a little more. By keeping motives and goals orientated around the faction or company, you can brand it, and use that branding in the world. Plus your party will naturally start to separate the employees, from the company. Pelican Corp is an evil weapons manufacturer, but Debbie in shipping is a heckin saint.

Have you tried the Altered Carbon RPG yet? Try the Quickstart Guide here and let us know your adventure in the comments!

Featured Image: Altered Carbon The Role-Playing Game

Image Credits: Altered Carbon

Rick Heinz is a storyteller with a focus on D&D For Kids, and an overdose of LARPs, and the author of The Seventh Age: Dawn. You can follow RPG or urban fantasy related thingies on Twitter or reach out for writing at [emailprotected]

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Sleeve Into Altered Carbon: The Role Playing Game - Nerdist

Functionalized Gold and Silver Bimetallic Nanoparticles Using Deinococ | IJN – Dove Medical Press

Yulan Weng, 1 Jiulong Li, 1 Xingcheng Ding, 2 Binqiang Wang, 1 Shang Dai, 1 Yulong Zhou, 3 Renjiang Pang, 1 Ye Zhao, 1 Hong Xu, 1 Bing Tian, 1, 3 Yuejin Hua 1

1MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang University, Hangzhou, Peoples Republic of China; 2Zhejiang Runtu Chemical Research Institute, Shaoxing, Peoples Republic of China; 3Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, Xinjiang, Peoples Republic of China

Correspondence: Bing TianZhejiang University Zijingang Campus West Part, A403 Biophysics Building, 866 Yuhangtang Road, Hangzhou 310058, Peoples Republic of ChinaTel/Fax +86-571-86971215Email tianbing@zju.edu.cn

Background: Biodegradation of toxic organic dye using nanomaterial-based microbial biocatalyst is an ecofriendly and promising technique.Materials and Methods: Here, we have investigated the novel properties of functionalized Au-Ag bimetallic nanoparticles using extremophilic Deinococcus radiodurans proteins (Drp-Au-AgNPs) and their degradation efficiency on the toxic triphenylmethane dye malachite green (MG).Results and Discussion: The prepared Drp-Au-AgNPs with an average particle size of 149.8 nm were capped by proteins through groups including hydroxyl and amide. Drp-Au-AgNPs demonstrated greater degradation ability (83.68%) of MG than D. radiodurans cells and monometallic AuNPs. The major degradation product was identified as 4-(dimethylamino) benzophenone, which is less toxic than MG. The degradation of MG was mainly attributed to the capping proteins on Drp-Au-AgNPs. The bimetallic NPs could be reused and maintained MG degradation ability (> 64%) after 2 cycles.Conclusion: These results suggest that the easilyprepared Drp-Au-AgNPs have potential applications as novel nanomedicine for MG detoxification, and nanomaterial for biotreatment of a toxic polyphenyl dye-containing wastewater.

Keywords: bimetallic nanoparticles, Deinococcus radiodurans, biodegradation, toxic triphenylmethane dye, malachite green, detoxification

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Functionalized Gold and Silver Bimetallic Nanoparticles Using Deinococ | IJN - Dove Medical Press