Join PC Gamer’s Folding@home team and help research a cure for Covid-19 – PC Gamer

A couple of weeks ago we learned about a new game called Foldit, developed by researchers at the University of Washington, that could help with the development of a treatment for the Covid-19 coronavirus. Essentially, players solve puzzles by folding protein chains into new shapes that change the function of the protein, with points awarded based on the effectiveness of the solution. Researchers can then experiment on those folded proteins in order to determine their usefulness in the real world.

If that game doesn't appeal to you, but you happen to be sitting beside an expensive, powerful PC that's not really doing anything, why not let it handle the task for you?

In Foldit you have to work for a spot on that leaderboard, but through Folding@home, you can put your PC to work. Folding@home is a distributed computing project founded by Stanford University in 2000 that uses idle PCs around the world for medical research, including the coronavirus pandemic.

The way it works, essentially, is that protein data is broken up into work units, which are then downloaded automatically by the Folding software. Your PC crunches away on it until the work unit is complete, at which point the result is uploaded to the server. A new work unit is downloaded, and the process starts again. As a weak but thematically appropriate analogy, it's a bit like Team Fortress 2, except extraordinarily slow, it's nothing but bots, and the whole world is playing in the same match.

You can fold by yourself (and bravo for doing your bit) but these things are always more fun when you're part of a teamsuch as the PC Gamer Folding@home Team. The setup instructions might look a little intimidating but it's actually quite simple, and once you're rolling it's entirely automated, although you can tweak various settings, like how much processing power to dedicate and whether or not you want it to work while you're using your PC.

If you do run into problems or have any questions with Folding@home, or just feel like chatting, the PC Gamer forum thread linked above can help out. The Folding website is struggling a little bit right now, but once it's squared away you'll be able to following along with the team's progress here.

We're maintaining a roundup of esports competitions and other gaming events that have been impacted by the coronavirus outbreak that you can keep up with here.For more information on the Covid-19 coronavirus, visit the Centers for Disease Control for updates in North America, the European Centre for Disease Prevention and Control, or the World Health Organization.

This is what it looks like when proteins fold.

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Join PC Gamer's Folding@home team and help research a cure for Covid-19 - PC Gamer

Why AI might be the most effective weapon we have to fight COVID-19 – The Next Web

If not the most deadly, the novel coronavirus (COVID-19) is one of the most contagious diseases to have hit our green planet in the past decades. In little over three months since the virus was first spotted in mainland China, it has spread to more than 90 countries, infected more than 185,000 people, and taken more than 3,500 lives.

As governments and health organizations scramble to contain the spread of coronavirus, they need all the help they can get, including from artificial intelligence. Though current AI technologies arefar from replicating human intelligence, they are proving to be very helpful in tracking the outbreak, diagnosing patients, disinfecting areas, and speeding up the process of finding a cure for COVID-19.

Data science and machine learning might be two of the most effective weapons we have in the fight against the coronavirus outbreak.

Just before the turn of the year, BlueDot, an artificial intelligence platform that tracks infectious diseases around the world, flagged a cluster of unusual pneumonia cases happening around a market in Wuhan, China. Nine days later, the World Health Organization (WHO)released a statementdeclaring the discovery of a novel coronavirus in a hospitalized person with pneumonia in Wuhan.

BlueDot usesnatural language processingandmachine learning algorithmsto peruse information from hundreds of sources for early signs of infectious epidemics. The AI looks at statements from health organizations, commercial flights, livestock health reports, climate data from satellites, and news reports. With so much data being generated on coronavirus every day, the AI algorithms can help home in on the bits that can provide pertinent information on the spread of the virus. It can also find important correlations between data points, such as the movement patterns of the people who are living in the areas most affected by the virus.

The company also employs dozens of experts who specialize in a range of disciplines including geographic information systems, spatial analytics, data visualization, computer sciences, as well as medical experts in clinical infectious diseases, travel and tropical medicine, and public health. The experts review the information that has been flagged by the AI and send out reports on their findings.

Combined with the assistance of human experts, BlueDots AI can not only predict the start of an epidemic, but also forecast how it will spread. In the case of COVID-19, the AI successfully identified the cities where the virus would be transferred to after it surfaced in Wuhan. Machine learning algorithms studying travel patterns were able to predict where the people who had contracted coronavirus were likely to travel.

Coronavirus (COVID-19) (Image source:NIAID)

You have probably seen the COVID-19 screenings at border crossings and airports. Health officers use thermometer guns and visually check travelers for signs of fever, coughing, and breathing difficulties.

Now,computer vision algorithmscan perform the same at large scale. An AI system developed by Chinese tech giant Baidu uses cameras equipped with computer vision and infrared sensors to predict peoples temperatures in public areas. The system can screen up to 200 people per minute and detect their temperature within a range of 0.5 degrees Celsius. The AI flags anyone who has a temperature above 37.3 degrees. The technology is now in use in Beijings Qinghe Railway Station.

Alibaba, another Chinese tech giant, has developed an AI system that candetect coronavirus in chest CT scans. According to the researchers who developed the system, the AI has a 96-percent accuracy. The AI was trained on data from 5,000 coronavirus cases and can perform the test in 20 seconds as opposed to the 15 minutes it takes a human expert to diagnose patients. It can also tell the difference between coronavirus and ordinary viral pneumonia. The algorithm can give a boost to the medical centers that are already under a lot of pressure to screen patients for COVID-19 infection. The system is reportedly being adopted in 100 hospitals in China.

A separate AI developed by researchers from Renmin Hospital of Wuhan University, Wuhan EndoAngel Medical Technology Company, and the China University of Geosciences purportedly shows 95-percent accuracy on detecting COVID-19 in chest CT scans. The system is adeep learning algorithmtrained on 45,000 anonymized CT scans. According to a preprint paperpublished on medRxiv, the AIs performance is comparable to expert radiologists.

One of the main ways to prevent the spread of the novel coronavirus is to reduce contact between infected patients and people who have not contracted the virus. To this end, several companies and organizations have engaged in efforts to automate some of the procedures that previously required health workers and medical staff to interact with patients.

Chinese firms are using drones and robots to perform contactless delivery and to spray disinfectants in public areas to minimize the risk of cross-infection. Other robots are checking people for fever and other COVID-19 symptoms and dispensing free hand sanitizer foam and gel.

Inside hospitals, robots are delivering food and medicine to patients and disinfecting their rooms to obviate the need for the presence of nurses. Other robots are busy cooking rice without human supervision, reducing the number of staff required to run the facility.

In Seattle, doctors used a robot to communicate with and treat patients remotely to minimize exposure of medical staff to infected people.

At the end of the day, the war on the novel coronavirus is not over until we develop a vaccine that can immunize everyone against the virus. But developing new drugs and medicine is a very lengthy and costly process. It can cost more than a billion dollars and take up to 12 years. Thats the kind of timeframe we dont have as the virus continues to spread at an accelerating pace.

Fortunately, AI can help speed up the process. DeepMind, the AI research lab acquired by Google in 2014, recently declared that it has used deep learning to find new information about the structure of proteins associated with COVID-19. This is a process that could have taken many more months.

Understanding protein structures can provide important clues to the coronavirus vaccine formula. DeepMind is one of several organizations who are engaged in the race to unlock the coronavirus vaccine. It has leveraged the result of decades of machine learning progress as well as research on protein folding.

Its important to note that our structure prediction system is still in development and we cant be certain of the accuracy of the structures we are providing, although we are confident that the system is more accurate than our earlier CASP13 system, DeepMinds researchers wroteon the AI labs website. We confirmed that our system provided an accurate prediction for the experimentally determined SARS-CoV-2 spike protein structure shared in the Protein Data Bank, and this gave us confidence that our model predictions on other proteins may be useful.

Although its too early to tell whether were headed in the right direction, the efforts are commendable. Every day saved in finding the coronavirus vaccine can save hundredsor thousandsof lives.

This story is republished fromTechTalks, the blog that explores how technology is solving problems and creating new ones. Like them onFacebookhere and follow them down here:

Published March 21, 2020 17:00 UTC

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Why AI might be the most effective weapon we have to fight COVID-19 - The Next Web

Thousands of These Computers Were Mining Cryptocurrency. Now Theyre Working on Coronavirus Research – Yahoo Money

CoreWeave, the largest U.S. miner on the Ethereum blockchain, is redirecting the processing power of 6,000 specialized computer chips toward research to find a therapy for the coronavirus.

These graphics processing units (GPUs) will be pointed toward Stanford Universitys Folding@home, a long-standing research effort that unveiled a project on Feb. 27 specifically to boost coronavirus research by way of a unique approach to developing pharmaceutical drugs: connecting thousands of computers from around the world to form a distributed supercomputer for disease research.

CoreWeave co-founder and Chief Technology Officer (CTO) Brian Venturo said the project has at least a shot at finding a drug for the virus. As such, CoreWeave has responded by doubling the power of the entire network with its GPUs, which are designed to handle repetitive calculations.

Related: State Power After Coronavirus, Feat. Peter McCormack

See also: Bitcoiners Are Biohacking a DIY Coronavirus Vaccine

According to Venturo, those 6,000 GPUs made up about 0.2 percent of Ethereums total hashrate, earning roughly 28 ETH per day, worth about $3,600 at press time.

There is no cure for the coronavirus just yet (though various groups are working on vaccines and research to combat the disease, including IBMs supercomputer). Venturo noted that Folding@home has been used to contribute to breakthroughs in the creation of other important drugs.

Their research had profound impacts on the development of front-line HIV defense drugs, and we are hoping our [computing power] will aid in the fight against coronavirus, Venturo said.

Related: SkyWeaver Didnt Plan for a Captive Audience of Millions but It Sure Helps

The coronavirus is taking a toll across the world. Italy and Spain are on lockdown. Conferences, stores and restaurants are closing to stem the spread of the disease; by stoking fears, its slamming the financial markets in the process.

When the idea of using GPUs for coronavirus research was mentioned to CoreWeave, the team didnt think twice.

They had a test system up and running within minutes, Venturo said. Since then, the project quickly snowballed. CoreWeave has been contributing over half of the overall computing power going into the coronavirus wing of Folding@home.

The idea of should we do this? was never really brought up, it kind of just happened. We were all enthusiastic that we might be able to help, Venturo added.

Folding@home is a decentralized project in the same vein as Bitcoin. Instead of one research firm alone using a massive computer to do research, Folding@home uses the computing power of anyone who wants to participate from around the world even if its just a single laptop with a little unused computing power to spare.

See also: Bitcoiners in Europe Reflect on Economic Shocks as Coronavirus Spreads

In this case, the computing power is used to find helpful information relating to the coronavirus. Much like in bitcoin mining, one user might detect a solution to the problem at hand, distributing this information to the rest of the group.

Their protein simulations attempt to find potential pockets where existing [U.S. federal agency Food and Drug Administration (FDA)] approved drugs or other known compounds could help inhibit or treat the virus, Venturo said.

Viruses have proteins that they use to suppress our immune systems and reproduce themselves. To help tackle coronavirus, we want to understand how these viral proteins work and how we can design therapeutics to stop them, a Folding@home blog post explains.

Simulating these proteins and then looking at them from different angles helps scientists to understand them better, with the potential of finding an antidote. Computers accelerate this process by shuffling through the variations very quickly.

Our specialty is in using computer simulations to understand proteins moving parts. Watching how the atoms in a protein move relative to one another is important because it captures valuable information that is inaccessible by any other means, the post reads.

Folding@home could use even more power. Venturo urges other GPU miners to join the cause.

Even without these calls for participation, though, miners of other cryptocurrencies are already independently taking action. Tulip.tools founder Johann Tanzer put out a call to action to Tezos bakers (that blockchains equivalent of miners) last week, promising to send the leading contributor to Folding@home a modest 15 XTZ, worth roughly $20 at press time.

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The initiative blew up, to Tanzers surprise. Though they might not be contributing as much power as CoreWeave, 20 groups of Tezos miners are now contributing a slice of their hashing power to the cause. Tanzers pot has swelled to roughly $600 as Tezos users caught wind of the effort and donated.

But thats not to say all miners can participate. While GPUs are flexible, application-specific integrated circuits (ASICs), a type of chip designed specifically for mining, arent, according to Venturo. Though ASICs are more powerful than GPUs, theyre really only made for one thing: To mine cryptocurrency. This is one advantage Venturo thinks Ethereum has over Bitcoin, since GPU mining still works on the former, whereas the latter is now dominated by ASICs.

See also: Israeli Bitcoiners See Surveillance as Unavoidable During Coronavirus Crisis

This is one of the great things about the Ethereum mining ecosystem, its basically the largest GPU compute resource on the planet. We were able to redeploy our hardware to help fight a global pandemic in minutes, Venturo said. (However, its worth noting that Ethereum has seen ASICs enter the fray. Not to mention, ether miners might soon go extinct when a pivotal upgrade makes its way into the network.)

ASICs are useless for the Folding@Home effort, but if bitcoin miners have old GPUs lying around from the early days that they could contribute, too.

Even if other miners join up, though, its still a long shot that the effort will lead to a helpful drug.

After discussing with some industry experts [] we believe the chance of success in utilizing the work done on Folding@Home to deliver a drug to market to be in the 2-5% range, Venturo said.

Continued here:
Thousands of These Computers Were Mining Cryptocurrency. Now Theyre Working on Coronavirus Research - Yahoo Money

How you can help find a drug to stop coronavirus by not using your computer – News 5 Cleveland

If you're reading this on a computer really, if you own a working computer you can help to find a potential treatment for coronavirus.

Folding@Home, a project that uses the collective computing power of thousands of computers around the world to simulate protein dynamics, is tackling SARS-COV-2, the novel coronavirus that causes COVID-19.

By downloading the Folding@Home software and letting it run simulations when your computer is idle, like when youre asleep and totally not scrolling through some quality quarantmemes on phone, youre helping scientists in the Bowman Lab at the University of Washington in St. Louis understand how the coronavirus proteins work, and how to design therapeutics to stop them.

Its similar to the long-running project SETI@Home, which is unfortunately ending the volunteer program this month. It uses distributed computing to analyze radio telescope data in the Search for Extraterrestrial Intelligence, and, by the way, if youre listening, we could use some help here.

By donating your spare computational power to Folding@Home, youll be a part of one of the worlds fastest computing systems, running at a speed of about 98.7 petaFLOPS, according to recent statistics from the site. Thats 10 to the 15th power FLOPS. A 98,000 teraFLOPS. The Titan Supercomputer cranks out a measly 20 petaFLOPS.

Folding@Home recently simulated a protein from Ebola virus that was considered undruggable, and after performing experiments confirming that prediction, theyre now on the hunt for drugs to bind to this newly discovered site.

Learn more about the project here.

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How you can help find a drug to stop coronavirus by not using your computer - News 5 Cleveland

Vegan hamburger steak rice bowls added to over 1900 convenience stores in Tokyo – Japan Today

You can find some pretty great stuff in Japanese convenience stores.Piping hot pizza buns?Delicious fried chicken in a variety of flavors?Meat sauce and seafood pasta forless than a buck? Yes, yes, and YES!

But whats hard to find at Japanese convenience stores arevegan options.Granted, they have salads, but even a lot of those contain egg and tuna, and if youre looking for an entire vegan meal, youre usually entirely out of luck at the convenience store.

Thats changing in a big way this week, though, thanks to theFamilyMartchain. On March 17, FamilyMart rolled out its newest premade donburi (rice bowl) offering:the 100-percent vegan Veggie Burg-don.

Alternatively called theSoy-Patty Burger Bowl, its a new take on Japans beloved hamburger steak, essentially a hamburger patty with extra onions and served without a bun. However, while most hamburger steaks in Japan are made of either beef or a beef/pork mixture, the Veggie Burg-donuses no meat, egg, honey, dairy, or any other animal products. Instead, the patty is made ofsoybeans and roast onion,prepared in a way that FamilyMart promisesrecreates not only the flavor, but the aroma, texture, and juiciness of a traditional hamburger steak.

But its not just hamburger steaks that are ordinarily meaty, but theirsauceas well. The most common accompaniment to a Japanese hamburger steak isdemi-glace, a rich meat-based brown sauce. Obviously that wont do for the Veggie Burg-don, though, so FamilyMarts facsimile is made fromflour roasted in vegetable oil, tomato, mushrooms, carrots, and other vegetables. If even all that isnt enough vegetables for you, the rice bowl also comes with sides of stewed carrots and roasted kabocha (Japanese pumpkin) and bell pepper.

The Veggie Burg-don is the first FamilyMart item to be awarded aseal of recommendation from the Japan Vegetarian Society.

With veganism having made its deepest inroads into the Japanese culinary scene in large, cosmopolitan cities, the 498-yen Veggie Burg-don will initially only be offered in Tokyo. However, with FamilyMart having roughly 2,000 branches in the city, thats a lot of new places to get a vegan meal, and if the product proves popular, well probably see it expand to the rest of the chains stores across Japan.

Source:FamilyMartviaIT Media

Read more stories from SoraNews24.

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-- We taste makunouchi bento at four Japanese convenience store chainsTastecomparison

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Vegan hamburger steak rice bowls added to over 1900 convenience stores in Tokyo - Japan Today

Demand for Plant-Based Omega 3 Set to Soar – vegconomist – the vegan business magazine

bit24 -stock-adobe.com

A recent market research report from P&S Intelligence has stated that one of the biggest trends currently being witnessed in the omega-3 market is the growth of veganism and the resultant consumption of plant-based supplements.

The report states that in 2019, the global omega-3 market size (containing fish oil) generated revenue of $19.7 billion, and is further expected to reach $49.7 billion by 2030. Transparency Market Research released a different report that specifically examines the plant-based omega 3 market; that report estimated that the fish-free Omega 3 market is expected to reach almost US$ 1.3 billion by 2029.

The interest is shifting from the type to the source of omega fatty acids across the health-aware consumers around the world, meaning that the demand for plant-based supplements will witness a massive surge over the next decade. Consumers are increasingly concerned over the safeguarding of marine ecosystems and biodiversity.

Fish obtain omega-3 by consuming algae, so it seems logical to bypass fish and go straight to the original plant source. As such, the usage of algae as a new alternative source to fish is therefore anticipated to grow rapidly in the plant-based omega-3 ingredients market. As well as algal oil, manufactures are developing products from chia seeds, flaxseed oil, canola oil, hemp seeds, walnuts, and others, which are also growing as fish-free omega-3 ingredients.

The Transparency Market report says, Stakeholders are expected to continue to bank on the growing population of vegan consumers and preference for algae or plant-based omega-3 ingredients to maintain the momentum. However, slow regulatory approvals will remain a primary challenge for market players, as they will continue to make it difficult for manufacturers to offer competitive prices and delay their products from reaching the fish-free omega-3 ingredients market.

Nevertheless, the ongoing trend of substituting krill oil in omega-3 dietary supplements with vegetarian algae oil will continue to support the growth of the fish-free omega-3 ingredients landscape in the foreseeable future.

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Demand for Plant-Based Omega 3 Set to Soar - vegconomist - the vegan business magazine

Aytu BioScience Expands Its Distribution Rights for Coronavirus 2019 (COVID-19) Point-of-Care Rapid Test to Canada and Mexico – Yahoo Finance

Company Expects to Seek Regulatory Clearance Under Health Canada and COFEPRIS Expedited Clearance Procedures

ENGLEWOOD, CO / ACCESSWIRE / March 19, 2020 / Aytu BioScience, Inc. (AYTU), a specialty pharmaceutical company focused on commercializing novel products that address significant patient needs announced today that it extended its distribution right to commercialize the clinically validated and commercially used coronavirus 2019 (COVID-19) IgG/IgM Rapid Test. The test has been licensed from L.B. Resources, Limited (a Hong Kong Corporation). The COVID-19 IgG/IgM Rapid Test is intended for professional use and delivers clinical results between 2 and 10 minutes at the point-of-care. This amendment expands Aytu's commercial rights and grants Aytu the right to distribute and commercialize the COVID-19 test in North America, specifically including the United States, Canada and Mexico.

The Company expects to pursue expedited regulatory clearance of the product with Health Canada and COFEPRIS (Comisin Federal para la Proteccin contra Riesgos Sanitarios), the regulatory agencies in Canada and Mexico, respectively.

Josh Disbrow, Chief Executive Officer of Aytu BioScience, commented, "We have to be progressive in doing our part in combatting the spread of the COVID-19 virus. We need to ensure that screening is available across North America and providing broad access to screening tests has to be among our highest priorities as we collectively fight the coronavirus outbreak. With COVID-19 now designated as a global pandemic, we believe we should expand our efforts to assist healthcare providers with faster point-of-care detection."

The COVID-19 IgG/IgM Rapid Test is a solid phase immunochromatographic assay used in the rapid, qualitative and differential detection of IgG and IgM antibodies to the 2019 Novel Coronavirus in human whole blood, serum or plasma. This point-of-care test has been validated in a 113 patient clinical trial and is CE marked.

About Aytu BioScience, Inc.

Aytu BioScience is a commercial-stage specialty pharmaceutical company focused on commercializing novel products that address significant patient needs. The company currently markets a portfolio of prescription products addressing large primary care and pediatric markets. The primary care portfolio includes (i) Natesto, the only FDA-approved nasal formulation of testosterone for men with hypogonadism (low testosterone, or "Low T"), (ii) ZolpiMist, the only FDA-approved oral spray prescription sleep aid, and (iii) Tuzistra XR, the only FDA-approved 12-hour codeine-based antitussive syrup. The pediatric portfolio includes (i) AcipHex Sprinkle, a granule formulation of rabeprazole sodium, a commonly prescribed proton pump inhibitor; (ii) Cefaclor, a second-generation cephalosporin antibiotic suspension; (iii) Karbinal ER, an extended-release carbinoxamine (antihistamine) suspension indicated to treat numerous allergic conditions; and (iv) Poly-Vi-Flor and Tri-Vi-Flor, two complementary prescription fluoride-based supplement product lines containing combinations of fluoride and vitamins in various for infants and children with fluoride deficiency. Aytu recently acquired exclusive U.S. distribution rights to the COVID-19 IgG/IgM Rapid Test. This coronavirus test is a solid phase immunochromatographic assay used in the rapid, qualitative and differential detection of IgG and IgM antibodies to the 2019 Novel Coronavirus in human whole blood, serum or plasma. This point-of-care test has been validated in a 113 patient clinical trial and has received CE marking.

Aytu recently acquired Innovus Pharmaceuticals, a specialty pharmaceutical company commercializing, licensing and developing safe and effective consumer healthcare products designed to improve men's and women's health and vitality. Innovus commercializes over thirty-five consumer health products competing in large healthcare categories including diabetes, men's health, sexual wellness and respiratory health. The Innovus product portfolio is commercialized through direct-to-consumer marketing channels utilizing the company's proprietary Beyond Human marketing and sales platform.

Aytu's strategy is to continue building its portfolio of revenue-generating products, leveraging its focused commercial team and expertise to build leading brands within large therapeutic markets. For more information visit aytubio.com and visit innovuspharma.com to learn about the company's consumer healthcare products.

Story continues

Forward-Looking Statement

This press release includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, or the Exchange Act. All statements other than statements of historical facts contained in this presentation, are forward-looking statements. Forward-looking statements are generally written in the future tense and/or are preceded by words such as ''may,'' ''will,'' ''should,'' ''forecast,'' ''could,'' ''expect,'' ''suggest,'' ''believe,'' ''estimate,'' ''continue,'' ''anticipate,'' ''intend,'' ''plan,'' or similar words, or the negatives of such terms or other variations on such terms or comparable terminology. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or results to differ materially. These risks and uncertainties include, among others: market and other conditions, the completion of the registered direct offering, the satisfaction of customary closing conditions related to the registered direct offering and the intended use of net proceeds from the registered direct offering, the regulatory and commercial risks associated with introducing the COVID-19 Rapid Test, effects of the business combination of Aytu and the Commercial Portfolio and the recently completed merger ("Merger") with Innovus Pharmaceuticals, including the combined company's future financial condition, results of operations, strategy and plans, the ability of the combined company to realize anticipated synergies in the timeframe expected or at all, changes in capital markets and the ability of the combined company to finance operations in the manner expected, the diversion of management time on Merger-related issues and integration of the Commercial Portfolio, the ultimate timing, outcome and results of integrating the operations the Commercial Portfolio and Innovus with Aytu's existing operations, risks relating to gaining market acceptance of our products, obtaining or maintaining reimbursement by third-party payors for our prescription products, the potential future commercialization of our product candidates, the anticipated start dates, durations and completion dates, as well as the potential future results, of our ongoing and future clinical trials, the anticipated designs of our future clinical trials, anticipated future regulatory submissions and events, our anticipated future cash position and future events under our current and potential future collaboration. We also refer you to the risks described in ''Risk Factors'' in Part I, Item 1A of the company's Annual Report on Form 10-K and in the other reports and documents we file with the Securities and Exchange Commission from time to time.

Contact for Media and Investors:

James CarbonaraHayden IR(646) 755-7412james@haydenir.com

SOURCE: Aytu BioScience, Inc.

View source version on accesswire.com: https://www.accesswire.com/581543/Aytu-BioScience-Expands-Its-Distribution-Rights-for-Coronavirus-2019-COVID-19-Point-of-Care-Rapid-Test-to-Canada-and-Mexico

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Aytu BioScience Expands Its Distribution Rights for Coronavirus 2019 (COVID-19) Point-of-Care Rapid Test to Canada and Mexico - Yahoo Finance

Aytu BioScience Announces Acceleration of U.S. Availability of COVID-19 IgG/IgM Rapid Test Based on Updated FDA Policy – Yahoo Finance

Updated FDA Policy Likely Enables Near-Term Availability of COVID-19 Test in the U.S.

ENGLEWOOD, CO / ACCESSWIRE / March 17, 2020 / Aytu BioScience, Inc. (AYTU), a specialty pharmaceutical company focused on commercializing novel products that address significant patient needs announced today that the company intends to expedite the U.S. launch of its recently licensed COVID-19 IgG/IgM Point-of-Care Rapid Test in light of yesterday's updated FDA policy on coronavirus diagnostic testing.

On March 16, 2020 the FDA announced, "as part of our ongoing and aggressive commitment to address the coronavirus outbreak, the FDA updated a policy originally issued on Feb. 29 on diagnostic testing for coronavirus (COVID-19) in order to achieve more rapid testing capacity in the U.S. We believe the unprecedented policy set forth in today's updated guidance, which addresses laboratories and commercial manufacturers, will help address these urgent public health concerns by helping to expand the number and variety of diagnostic tests..." Further, the agency made recommendations specifically for test developers stating that "the FDA does not intend to object to the distribution and use of serology tests to identify antibodies to SARS-CoV-2 where the test has been validated" and other labeling conditions are satisfied.

Josh Disbrow, Chief Executive Officer of Aytu BioScience, commented, "While we are still working with FDA on making the COVID-19 Rapid Test available, we believe that this updated policy may enable near-term availability of our recently-licensed point-of-care test. During this public health emergency, we are working tirelessly to satisfy all requirements in order to make the test available to the professional medical community as soon as possible." Disbrow also commented that, "We have already gotten confirmation from the manufacturer that our initial supply is being shipped and is expected to arrive in the U.S. very soon."

The company will continue to provide updates about the near-term availability of the COVID-19 test.

About Aytu BioScience, Inc.

Aytu BioScience is a commercial-stage specialty pharmaceutical company focused on commercializing novel products that address significant patient needs. The company currently markets a portfolio of prescription products addressing large primary care and pediatric markets. The primary care portfolio includes (i) Natesto, the only FDA-approved nasal formulation of testosterone for men with hypogonadism (low testosterone, or "Low T"), (ii) ZolpiMist, the only FDA-approved oral spray prescription sleep aid, and (iii) Tuzistra XR, the only FDA-approved 12-hour codeine-based antitussive syrup. The pediatric portfolio includes (i) AcipHex Sprinkle, a granule formulation of rabeprazole sodium, a commonly prescribed proton pump inhibitor; (ii) Cefaclor, a second-generation cephalosporin antibiotic suspension; (iii) Karbinal ER, an extended-release carbinoxamine (antihistamine) suspension indicated to treat numerous allergic conditions; and (iv) Poly-Vi-Flor and Tri-Vi-Flor, two complementary prescription fluoride-based supplement product lines containing combinations of fluoride and vitamins in various for infants and children with fluoride deficiency.

Aytu recently acquired Innovus Pharmaceuticals, a specialty pharmaceutical company commercializing, licensing and developing safe and effective consumer healthcare products designed to improve men's and women's health and vitality. Innovus commercializes over thirty-five consumer health products competing in large healthcare categories including diabetes, men's health, sexual wellness and respiratory health. The Innovus product portfolio is commercialized through direct-to-consumer marketing channels utilizing the company's proprietary Beyond Human marketing and sales platform.

Aytu's strategy is to continue building its portfolio of revenue-generating products, leveraging its focused commercial team and expertise to build leading brands within large therapeutic markets. For more information visit aytubio.com and visit innovuspharma.com to learn about the company's consumer healthcare products.

Forward-Looking Statement

This press release includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, or the Exchange Act. All statements other than statements of historical facts contained in this presentation, are forward-looking statements. Forward-looking statements are generally written in the future tense and/or are preceded by words such as ''may,'' ''will,'' ''should,'' ''forecast,'' ''could,'' ''expect,'' ''suggest,'' ''believe,'' ''estimate,'' ''continue,'' ''anticipate,'' ''intend,'' ''plan,'' or similar words, or the negatives of such terms or other variations on such terms or comparable terminology. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or results to differ materially. These risks and uncertainties include, among others: the regulatory and commercial risks associated with introducing the COVID-19 Rapid Test, effects of the business combination of Aytu and the Commercial Portfolio and the previously announced, but not yet consummated, merger ("Merger") with Innovus Pharmaceuticals, including the combined company's future financial condition, results of operations, strategy and plans, the ability of the combined company to realize anticipated synergies in the timeframe expected or at all, changes in capital markets and the ability of the combined company to finance operations in the manner expected, the diversion of management time on Merger-related issues and integration of the Commercial Portfolio, the ultimate timing, outcome and results of integrating the operations the Commercial Portfolio and Innovus with Aytu's existing operations, the failure to obtain the required votes of Innovus' shareholders or Aytu's shareholders to approve the Merger and related matters, the risk that a condition to closing of the Merger may not be satisfied, that either party may terminate the merger agreement or that the closing of the Merger might be delayed or not occur at all, the price per share utilized in the formula for the initial $8 million merger consideration in the Merger may not be reflective of the current market price of Aytu's common stock on the closing date, potential adverse reactions or changes to business or employee relationships, including those resulting from the announcement or completion of the Merger, risks relating to gaining market acceptance of our products, obtaining or maintaining reimbursement by third-party payors, the potential future commercialization of our product candidates, the anticipated start dates, durations and completion dates, as well as the potential future results, of our ongoing and future clinical trials, the anticipated designs of our future clinical trials, anticipated future regulatory submissions and events, our anticipated future cash position and future events under our current and potential future collaboration. We also refer you to the risks described in ''Risk Factors'' in Part I, Item 1A of the company's Annual Report on Form 10-K and in the other reports and documents we file with the Securities and Exchange Commission from time to time.

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Aytu BioScience Announces Acceleration of U.S. Availability of COVID-19 IgG/IgM Rapid Test Based on Updated FDA Policy - Yahoo Finance

Global Nanomedicine Market Executive Summary and Analysis by Top Players 2020 – 2025 : GE Healthcare, Johnson & Johnson – Stock Market Herald

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Global Nanomedicine Market Executive Summary and Analysis by Top Players 2020 - 2025 : GE Healthcare, Johnson & Johnson - Stock Market Herald

Nanoparticle Therapy Might Help Reduce Brain Swelling in… : Neurology Today – LWW Journals

Article In Brief

Mice with an open- and closed-traumatic brain injury were injected with immunomodulatory nanoparticles that reduced brain swelling and damage on MRI.

Investigators used a novel approach to prevent the swelling that can occur after traumatic brain injury (TBI) in a mouse model: they injected nanoparticles that trick white blood cells into going after them instead of rushing to the injured brain and causing an inflammatory and immune response.

Mice with TBI that were given three injections of the immunomodulatory nanoparticles beginning two to three hours after injury showed less brain swelling and damage on MRI as compared with mice with TBI that did not get the nanoparticles; the treated mice also performed better on functional tests.

The immunomodulatory nanoparticle treatment, if further proven in preclinical trials and human trials, would not undo damage from the initial injury to the brain. But it could help prevent the body from setting off a cascade of immune and inflammatory cells in reaction to the injury, which in turn can cause brain swelling and even more damage to brain tissue.

We certainly haven't gone and magically prevented that initial damage, said Jack Kessler, MD, professor of neurology at Northwestern University Feinberg School of Medicine and the senior author of the paper. What we can do is prevent the secondary damage, which is substantial.

Predicting which TBI patients will develop edema of the brain isn't easy, so having a preventive treatment like the nanoparticles that could be administered upfront could be life-altering, Dr. Kessler said.

He said some patients with head injuries come into the hospital walking and talking, but then their brain swells, and they die.

According to background in the study, published January 10 online in Annals of Neurology, each year more than 2.5 million people in the US have a traumatic brain TBI and more than five million Americans live with at least one sequela of TBI.

After the primary injury, there is substantial secondary injury attributable to infiltrating immune cells, cytokine release, reactive oxygen species, excitotoxicity, and other mechanisms, the study authors wrote. Despite many preclinical and clinical trials to limit such secondary damage, no successful therapies have emerged.

The nanoparticles tested in the mouse experiments are made of material used in biodegradable sutures. The paper specifically described the particles as highly negatively charged, 500 nm-diameter particles composed of the Food and Drug Administration (FDA)-approved biodegradable biopolymer carboxylated poly (lactic-co glycolic) acid.

The nanoparticles (IMPs), which seem like foreign invaders to the body's immune system, attract the attention of large white blood cells known as monocytes, which have been implicated in the secondary damage that occurs with TBI.

IMPs bind to the macrophage receptor with collagenous structure (MARCO) on monocytes and monocytes bound to IMPs no longer home to sites of inflammation but rather are sequestered in the spleen, where the cells die, the study authors wrote.

The mouse study involved two types of head injury. In some of the mice, the researchers performed a craniotomy to create a controlled cortical impact. Other mice received a closed head injury involving a direct blow to the head. Both types of injuries were meant to mimic what occurs in humans with TBI.

Injections of the nanoparticles were given two to three hours after the brain injury, and again at 24 hours and 48 hours post-injury. Control animals with similar brain injuries were given saline solution at the same time points.

Outcomes for the mice who received the nanoparticles were better by multiple measures, including MRI and a motor function test called the ladder rung walking test that is used in mouse experiments.

IMP administration resulted in remarkable preservation of both tissue and neurological function, in both models of head injury, the paper said. After acute treatment, there was a reduction in the number of immune cells infiltrating into the brain, mitigation of the inflammatory status of the infiltrating cells, improved electrophysiological visual function, improved long-term motor behavior, reduced edema formation as assessed by magnetic resonance imaging, and reduced lesion volumes on anatomic examination.

Dr. Kessler said that in the case of mice with an open head injury, the size of their brain lesion was 50 percent smaller in the treated animals compared with those that did not get the nanoparticles.

He said MRI showed significantly less brain swelling and less compression of the ventricles, both signs that secondary damage was minimized.

Dr. Kessler said that right now the only recourse for severe brain swelling is to do a craniotomy to relieve pressure in the skull.

He said one of the appeals of the nanoparticle treatment is that an emergency medical technician could do it in the field or the emergency room personnel could inject it.

But Dr. Kessler is also cautious about too many predications based on a pre-clinical study, saying he is fond of telling medical students that if I had a nickel for every mouse we cured, I'd be a rich man.

Sripadh Sharma, PhD, an MD-PhD student at Northwestern and the study's first author, said the nanoparticle therapy needs to be tested further in animal models before it could go into human testing. The researchers also want to learn more about how the nanoparticles bring about a reduced immune response in the body.

Dr. Sharma noted that while immune responses are a good thing in the face of injury or infection, sometimes nature doesn't always get it right, so too much of a good thing is a bad thing. And that can be the case with TBI.

He said it has been shown by another collaborator on the study, Stephen Miller, PhD, that when the scavenger receptors on the monocytes detect the light negative charge of the nanoparticles, the monocytes engulf and bind to the particles and apoptose in the spleen instead of going to the site of injury.

More studies need to be done to optimize what dose and what time these particles need to be given following a head injury, said Dr. Sharma.

Similar nanoparticle therapy is being tested for other medical conditions, including celiac disease and myocardial infarction, Dr. Kessler said.

Michael J. Schneck, MD, FAAN, professor of neurology (and neurosurgery) at Loyola University Chicago, said the study was well-designed and thorough, using two different head injury models and multiple outcome measures, including brain imaging, functional testing, and brain tissue analysis. Dr. Schneck said the paper made him wonder whether a similar approach using immune-modulating nanoparticles could reduce inflammatory-related damage following stroke and spinal cord injury.

Dr. Schneck said the concept of trying to dampen the immune response after TBI to prevent edema is not new, but the Northwestern researchers took the idea in a new direction. The nanoparticle therapy is particularly intriguing, he said, because it is fairly simple and involves the use of a material that is already approved by the US FDA, which could mean that it would take less time to move the therapy from the laboratory into clinical trials.

This is a very elegant study with interesting translational potential, he said. But it is a mouse model and its application to (human) TBI and other forms of central nervous system injury remains to be validated.

Jiangbing Zhou, PhD, associate professor of neurosurgery and biomedical engineering at Yale University, said that as someone who does research in the field of nanomedicine, he was surprised by the study's findings and wants to understand how this simple formulation particle could achieve this marked efficacy.

The study looks very exciting, but I want to know more about the mechanism, said Dr. Zhou, whose research focuses on developing translational nanomedicine, gene therapy, and stem cell therapy for neurological disorders including TBI.

He had these and other questions about the study: Why do the particles interact specifically with the inflammatory monocytes but not the others? How do the particles, which are made of safe biomaterials, efficiently kill the inflammatory monocytes in the spleen? What is happening and why?

Javier Crdenas, MD, director of the Barrow Concussion and Brain Injury Center at the Barrow Neurological Institute, said the study on the immune-modulating nanoparticle therapy for TBI was very promising, though he stressed that he is always cautiously optimistic when he sees a mouse study.

It is definitely a novel approach to addressing the secondary sequelae of brain injury and they might have something that minimizes that and hopefully improves outcomes, Dr. Crdenas said.

He said the study also raises some questions, including how the immune-modulating approach would fare in patients who have multiple injuries, not just to the head.

Dr. Crdenas said brain injuries often do not happen in isolation, with patients also having broken bones, lacerations, and other organ damage.

We don't know how this (nanoparticle treatment) would affect other organs, other immune responses elsewhere in the body, he said.

Dr. Crdenas said the field of TBI research has been disappointed before by studies of new therapies that looked promising in animal models and clinical testing but ultimately failed. He noted, for instance, that progesterone and hypothermia did not turn out to be good at preventing brain swelling.

We will wait and see, he said of the nanoparticles.

Drs. Sharma, Schneck, Zhou, and Crdenas had no disclosures.

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Nanoparticle Therapy Might Help Reduce Brain Swelling in... : Neurology Today - LWW Journals

What swarm robotics has taught me about leading a team working on swarm robotics – SDTimes.com

As a roboticist and engineer, one of the growing areas Im most excited about is the advancement of swarm robotics. I love the idea of taking inspiration from biological systems to enhance what autonomous robots can achieve collectively, and re-contextualizing social animal behaviors like flocking, foraging, and transport to create new possibilities for humanity. From nanomedicine and environmental monitoring to search and rescue and space exploration, theres no shortage of beneficial applications for swarms.

While robot swarm intelligence might sound intimidatingly high tech, its predicated on a very relatable concept. Just as robots within a swarm must operate collaboratively to solve shared problems, human teams need to work together to accomplish common objectives. In my experience working with a multidisciplinary team to commercialize autonomous aerial robots, Ive learned that you can transpose a number of key principles from robot swarm intelligence to enhance the approach to team leadership.

Organization >> IndividualIn the swarm model, the primary intention is to produce meaningful behavior at the grouprather than the individuallevel. While the individual robot is capable of operating on its own, its also intelligent enough to understand that when the group works together, the whole result becomes greater than the sum of its parts. Take one biological inspiration as an example: starlings. Scientists believe they form flocks primarily for safety because individually, they are quite agile and quick to avoid predators. But by forming a murmuration, they actually increase every individuals chance of survival by confusing predators, and increase the safety of the group as a whole.

This type of thinking is also true for an organization in which people work together in orchestrated harmony toward a common goal, and prioritize shared success over personal recognition. The challenge is that, if you manage a diverse team like myself, youll need to translate these objectives in a way that resonates with everyone. This is the key to cultivating coherence and a teamwork mindset between people from different functions, skill sets, and roles. For example, if you clearly align the technical details of your product with the real-world business requirements and outcomes, you can contextualize the full impact of the work for your technologists and engineers, beyond their individual subject matter areas. This helps synthesize efforts, and can also dissuade informational and cultural silos from forming.

In addition, make it a point to give credit where credit is due. This can go a long way in helping team members feel seen, and acknowledging the value of their hard work and contributions. It also helps take the pressure off of those who may feel like they constantly need to prove themselves to the group.

Structured, efficient, effective communicationOne reason swarms are able to achieve unparalleled scalability is by relying primarily on local, robot-to-robot communication to share information, which helps eliminate the dependence on a centralized infrastructure. This is especially useful if you are operating swarms in dangerous or otherwise inaccessible and unfamiliar areas, where you cant necessarily have a human operator within the same environment to work alongside and monitor the swarm. When the swarm does need to transmit critical information to a remote location (e.g., wherever the humans reside), it can tap special individual membersso-called gateway robotscapable of aggregating the local data and then relaying it via global communication.

Understanding how critical information is shared within the swarm and to external sources presents interesting parallels for human teams as well. For example, when is one-to-one communication more effective than one-to-many, and vice versa? And how frequently should these touch points happen? Perhaps specialty groups need to huddle more frequently and less formally, but the whole company would benefit from more structured communications at regular intervals. Perhaps you decide that team leaders should also act as gateway communicators in streamlining information flow across the company, and that this affects how you evaluate who is best suited for that role.

Whether robot or human, we all need to identify the specific challenges we each face to efficient and effective communication, and devise ways to overcome them. For robots, these might include technical issues and real-world limitationsthings like latency, bandwidth, asynchrony, topological changes, etc. Humans, meanwhile, need to devise a clear plan for unifying information across disparate tools and systems, managing handoffs, and addressing work-culture differences.

Build robustness from the ground upAnother remarkable quality of robot swarms is their robustness. They are designed such that, if any one component were to fail or malfunction, the system can continue performing its tasks as normal. Its like how the newer Christmas lights have fail protection in their circuitryif one bulb goes out, the rest of the string keeps shining. In this sense, swarms have built-in safety nets. By distributing and decentralizing the system across multiple units, you reduce the overall risk that something goes wrong.

From a leadership perspective, robustness can be addressed in two key ways: in the development of the technology and in the approach to team culture. On the technology side, for example, we focus on higher quality, modular code with less interdependencies, putting processes in place for continuous assessment and validation, and ensuring aggressive requirements for testing from start to finish. (This is where autonomous robots differ dramatically from other types of software-based tech. You cant just test in a sandbox or a simulated environmentonly real-world field testing will ensure you deliver the best product!)

On the team culture side, we build different kinds of safety nets. We focus on leading with a foundation of trust and respect, and put protocols in place to help affirm a positive work environment. For example, we set mutual expectations among teams or individuals for reaching certain milestones, to encourage a sense of shared responsibility and ownership instead of making people feel like they are being assigned a task list. Both the CEO and myself have standing open-door policies, in which we welcome anyone to approach us and raise concerns or discuss important issues. We have regular team building and team wellness days, where we dedicate time for meaningful, non-work activities to boost well-being and morale. As a recent example, we held a company offsite to hear a former NASA astronaut share his perspective on the value of teamwork in solving seemingly impossible challengeswhich we followed up with an escape room exercise. Its important to us to create a workplace that makes everyone feel included and valued, and helps each team member be at their very best.As a bonus benefit, these three principlesorganizational alignment, effective communication, and robustnessare also what help swarms to be flexible in quickly adapting to unexpected changes in their environment. In the face of unpredictability, uncertainty about the future, and every-evolving needs and requirements, technology-driven businesses need to think about fortifying themselves to weather the storm. Why not take inspiration from technology itself?

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What swarm robotics has taught me about leading a team working on swarm robotics - SDTimes.com

In vivo Comparison of the Biodistribution and Toxicity of InP/ZnS Quan | IJN – Dove Medical Press

Li Li,1,2 Yajing Chen,1 Gaixia Xu,2,3 Dongmeng Liu,1 Zhiwen Yang,1 Tingting Chen,1 Xiaomei Wang,1 Wenxiao Jiang,1 Dahui Xue,1 Guimiao Lin1

1Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, Shenzhen Key Laboratory of Synthetic Biology, Department of Physiology, School of Basic Medical Sciences, Shenzhen University, Shenzhen 518055, Peoples Republic of China; 2Key Laboratory of Optoelectronics Devices and Systems of Ministry of Education/Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, Peoples Republic of China; 3Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518055, Peoples Republic of China

Correspondence: Guimiao LinSchool of Basic Medical Sciences, Shenzhen University Health Sciences Center, Shenzhen 518060, Peoples Republic of ChinaTel/ Fax +86-755-86671903Email gmlin@szu.edu.cn

Introduction: Indium phosphide (InP) quantum dots (QDs) have shown a broad application prospect in the fields of biophotonics and nanomedicine. However, the potential toxicity of InP QDs has not been systematically evaluated. In particular, the effects of different surface modifications on the biodistribution and toxicity of InP QDs are still unknown, which hinders their further developments. The present study aims to investigate the biodistribution and in vivo toxicity of InP/ZnS QDs.Methods: Three kinds of InP/ZnS QDs with different surface modifications, hQDs (QDs-OH), aQDs (QDs-NH2), and cQDs (QDs-COOH) were intravenously injected into BALB/c mice at the dosage of 2.5 mg/kg BW or 25 mg/kg BW, respectively. Biodistribution of three QDs was determined through cryosection fluorescence microscopy and ICP-MS analysis. The subsequent effects of InP/ZnS QDs on histopathology, hematology and blood biochemistry were evaluated at 1, 3, 7, 14 and 28 days post-injection.Results: These types of InP/ZnS QDs were rapidly distributed in the major organs of mice, mainly in the liver and spleen, and lasted for 28 days. No abnormal behavior, weight change or organ index were observed during the whole observation period, except that 2 mice died on Day 1 after 25 mg/kg BW hQDs treatment. The results of H&E staining showed that no obvious histopathological abnormalities were observed in the main organs (including heart, liver, spleen, lung, kidney, and brain) of all mice injected with different surface-functionalized QDs. Low concentration exposure of three QDs hardly caused obvious toxicity, while high concentration exposure of the three QDs could cause some changes in hematological parameters or biochemical parameters related to liver function or cardiac function. More attention needs to be paid on cQDs as high-dose exposure of cQDs induced death, acute inflammatory reaction and slight changes in liver function in mice.Conclusion: The surface modification and exposure dose can influence the biological behavior and in vivo toxicity of QDs. The surface chemistry should be fully considered in the design of InP-based QDs for their biomedical applications.

Keywords: InP/ZnS quantum dots, surface chemistry, in vivo, biodistribution, nanotoxicology

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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In vivo Comparison of the Biodistribution and Toxicity of InP/ZnS Quan | IJN - Dove Medical Press

Last Nights on Londons Stages, Before the Lights Went Out – The New York Times

LONDON Nol Coward wrote Blithe Spirit in a mere six days, and the perennially popular play opened on the West End in 1941, running for nearly 2,000 performances setting a record in London for a nonmusical.

Its longevity back then is in stark contrast with the most recent outing of the play here, with Jennifer Saunders, of Absolutely Fabulous fame, playing the bicycle-riding medium Madame Arcati, who communicates with the dead. A victim of circumstances beyond the control of even the most supernaturally minded, the director Richard Eyres comparatively somber revival played its last performance at the Duke of Yorks Theater on March 14; the run had been due to finish on April 11.

The production closed early after Londons West End theaters took coordinated action on Monday to close themselves down and help stop the spread of the coronavirus. Londons West End, like Broadway, has gone dark, and no one knows when the lights will come back on.

As premature closings go, the timing here was somewhat ironic, when you consider how audiences throughout World War II flocked to Blithe Spirit, Cowards inquiry into the frustrations, erotic and otherwise, of Charles (Geoffrey Streatfeild), a novelist whose first wife returns from the grave. (She died, were told, while recovering from pneumonia, which may well have had an eerie resonance for nervous playgoers today.)

When she rises up, the mischievous Elvira (Emma Naomi) scatters calculated chaos in her wake. Its giving nothing away to tell you that she ends up taking Charless second wife, the whiplash-tongued Ruth (Lisa Dillon, giving the performance of the night), over to the other side with her, though neither woman will go quietly from the land of the living.

This was easily the least buoyant Blithe Spirit Ive seen, which was presumably intentional on the part of Eyre, the distinguished director who once ran the National Theater. The trend of late has been to find in Cowards outwardly breezy plays something more psychologically acute, as was the case when Andrew Scott, of Fleabag fame, stormed the Old Vic last summer in Present Laughter. Against expectation, a character long presented as a devil-may-care narcissist was revealed to be an anxious man-child, as well. Both revivals remind us that Coward possessed a keen understanding of human behavior, in addition to a quick wit.

In this Blithe Spirit, Charles and Ruths marriage seems far from blissful well before Elvira arrives on the scene, and Eyre takes the verbal brickbats they lob at each other for real. This, like Present Laughter, is a Coward play centered around a man who draws women to him when he would rather be left alone: Both plays end with their flustered heroes fleeing female companionship, but for what precisely? Coward leaves the sequels up for grabs.

The fate of this show, however, is sealed though no one could have guessed how quickly it would flit from view. Think of the cast as the casualties of an invisible terror. It was one that Saunders, top-billed albeit in a supporting role that Judi Dench is playing in a forthcoming film, acknowledged when Madame Arcati a germaphobe before her time reacted in spontaneous disgust at shaking another characters hand. I doubt those who laughed at that gesture last week would do so now.

Across London last week, a city in gathering distress was met with theater that chimed with the prevailing mood. Before the shutdown, I caught what turned out to be the final matinee of Shoe Lady, an arrestingly quirky play from E.V. Crowe at the Royal Court Theater, best described as a surrealist nightmare in the style of Caryl Churchill.

Its like were all on the edge, says Viv, a realtor whose life goes into free-fall when she loses a shoe on the London Underground. Buck up, she says, all the while succumbing to a growing sense of anxiety, brilliantly captured by Katherine Parkinson, accentuating her characters panic the more determinedly she keeps smiling. Running just over an hour, Vicky Featherstones production cant have anticipated how much the play, which might otherwise have seemed a theatrical caprice, felt instead like a parable of precariousness in a society that, much like Viv, seems to be losing its grip.

The connection between life and art was even more keenly felt on Monday at the Southwark Playhouse, in southeast London, one of the few theaters to offer a show on the evening when the bigger houses around town were calling it quits.

There, I was among a surprisingly full house to catch the last performance of the director Jonathan OBoyles hyper-intense revival of The Last Five Years, the Jason Robert Brown musical about a couple falling apart. (Think of it as the Marriage Story of the early 2000s.) The conceit of a show that alternates perspectives across 90 minutes is that one character, Jamie (the excellent Oli Higginson), tells his version of events from the beginning, whereas his ex, Cathy (Molly Lynch), begins her version of events at the end.

But there was no doubt for those in the room that we were all witnessing a finish of a different sort, given that it is entirely unclear when any of us will find ourselves in a London playhouse again. The audience that night had seemed especially focused, as if everyone present was savoring for keeps the experience of live performance.

Taking an empty Underground train home, I couldnt help but feel that Jamie and Cathys unraveling had acquired a resonance well beyond what the composer-lyricist Brown could have imagined. I wont soon forget the surge of feeling throughout the auditorium when the show got to its closing sequence, and ended on a single word: Goodbye.

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Last Nights on Londons Stages, Before the Lights Went Out - The New York Times

Relieve stress in your garden, as pressures from pandemic increase – Buffalo News

When the world wearies and society fails to satisfy, there is always the garden.

That sentiment, well known to gardeners, came from an early 20th century poet, Minnie Aumonier. It has spoken to me personally, as I have escaped to my garden in times of stress, worry or tiredness, but I am not alone in the feeling.

Gardeners through the ages have written of the benefits of gardening, which have proven to be much more than sentimental and emotional. Science validates that gardening is good for the human body, mind and spirit.

In response to COVID-19, many of us are experiencing new pressures. We have to adapt work, play and habits. Fortunately, gardening is something we can continue to do, and its important we do so.

From voices past and present, we receive the message that gardening and being in touch with nature is healthful for us, especially in tough times.

Consider just a few of those voices:

Gardening is a labour full of tranquility and satisfaction; natural and instructive, and as such contributes to the most serious contemplation, experience, health, and longevity. John Evelyn, 1620-1706 English writer, gardener, diarist.

Just for ones health ... it is very necessary to work in the garden and to see the flowers growing. Vincent van Gogh, 19th century Dutch painter.

Gardening is the greatest tonic and therapy a human being can have. Even if you have only a tiny piece of earth, you can create something beautiful, which we all have a great need for. If we begin by respecting plants, its inevitable well respect people. Audrey Hepburn, late actress and humanitarian.

Gardening is the most therapeutic and defiant act you can do; especially in the inner city, you get strawberries. Ron Finley, Los Angeles-based fashion designer known as the gangsta gardener.

Gardening simply does not allow one to be mentally old, because too many hopes and dreams are yet to be realized. Allan Armitage, horticulture professor, University of Georgia, author of numerous gardening reference books.

(For more quotes like these, and essays on gardening, see Teresa Watkins A Gardeners Compendium book series.)

With as much breadth and variety as writers and poets, scientists have published findings about the physical and mental health benefits of gardening.

From the Mayo Clinic to the National Institutes of Health and the World Health Organization, a wide range of field experiments have concluded gardening is beneficial for health whether physical (heart, nutrition, endocrine and digestive systems) or mental (dementia, memory loss, sleep disorders, depression and perceived stress) among other pathologies.

For thousands of Western New York gardeners, the benefits of gardening are self-evident. We dont need poets or scientists to tell us. Seeing the first green shoots or daffodils or daylilies produces smiles. On a sunny day, with a hint of spring in the air, simply picking up sticks is exhilarating.

As we go through extra-stressful times, be sure to give ourselves the respite and simple joy of it. Fresh air and sunshine are still free. Gardening doesnt have to be expensive. Plants can grow from seeds or little seedlings.

Gardening is not competitive and you dont have deadlines. In sadness or under stress, we can almost always feel better in a garden.

Gardening allows the best social distancing: It still takes place outside.

Sally Cunningham is a garden writer, lecturer and consultant.

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Relieve stress in your garden, as pressures from pandemic increase - Buffalo News

UK and Yemen: The Catch-22 contortions of an unethical foreign policy – Middle East Eye

When you look at the footage of so-called Yemeni special security forces attacking Aden airport five years ago today - gaunt young men in sandals and shorts gingerly approaching their target - the only thing that appears to match their billing is their military hardware.

Creeping behind powerful armoured cars, with machine guns and rocket launchers slung over their shoulders, they wait to break cover and storm the gates.

That morning, they lost the battle, but the war they started continues to rage, albeit under new management.

Originally, those special forces were fighting alongside Houthi rebels to oust President Abd Rabbuh Mansour Hadi and reinstall his predecessor, Ali Abdullah Saleh.

That seems a world away now. Salehs double-dealing eventually got him killed in 2017. Hadi is exiled and largely irrelevant in Riyadh.

If the last five years in Yemen have taught me anything ... it's the need to take other people's power struggles out of our equations, and take politics entirely out of our arms trade

Now what matters is the power struggle between the megalomaniacal Saudi Crown Prince Mohammed bin Salman, keen to add military genius to his list of precocious talents, and the fanatical Houthis, whod rather see Yemen destroyed than surrendered.

That explains both the longevity of the Yemen war, and also the sheer level of devastation it has caused. Put simply, neither side cares.

For Mohammed bin Salman, his indiscriminate air strikes and crippling blockades are yet to force a surrender, but not for the want of effort.As for the thousands of civilians blown to bits in the bombing, and the millions of children suffering malnutrition and disease, his Western allies dont seem bothered, so why should he?

The Houthis have their own long record of war crimes - child soldiers, torture, human shields, and random missile strikes on Riyadh.But the PR war has never bothered them; only the real one. And if you said it would last another five years, theyd probably count that a success.

So do we think either Mohammed bin Salman or the Houthis care about the imminent spread of coronavirus among a severely weakened population with an already shattered healthcare system?

If I sound in despair, forgive me.But what really gets me about Yemen is the sheer amount our Tory government actively chooses not to do when it comes to bringing the war to an end.

As the official UN penholder on Yemen, we could demand a comprehensive, nationwide ceasefire to allow proper peace talks and the mass distribution of humanitarian aid.We could demand a full, independent UN investigation into all alleged war crimes, and impose - with no exemptions - a total ban on all UK arms sales for use in Yemen until that investigation is complete.

Ive made those three demands of all four Tory foreign secretaries Ive faced, and everyone has refused - not for reasons of high principle or substantive policy, but just because of the naked politics that Mohammed bin Salman is in a power struggle, and they must be seen to back him up.

Watching all that across the dispatch box has changed me.It has taught me to hate the Catch-22 contortions of an unethical foreign policy - one where we accept that British arms have enforced blockades used to starve Houthi-held areas into submission, and deny children essential medical treatment.

Theyve been used to bomb weddings, funerals, school buses, food markets, homes, schools and hospitals. An impartial observer might therefore conclude there is a clear risk UK arms are being used to commit war crimes, and block their export accordingly.

But not the UK government.Instead, they applaud Saudi authorities for taking these concerns seriously and investigating all allegations, both - they argue - clear examples of good intent, and signs of positive UK influence.

Furthermore, because these investigations have supposedly only revealed a series of unfortunate accidents, not deliberate war crimes, the Tories say Riyadh deserves praise for admitting the former, not an unjustified arms ban to prevent the latter.

We must stop outsourcing UK foreign policy to Donald Trump

That, the Tories conclude, is consistent with the licensing rules put in place by former foreign secretary Robin Cook, even though Cook would have been appalled to see them applied in this way.

It was after hearing this crazed Conservative logic that I told Labour colleagues it would not be enough for us to simply operate the current arms export regime more stringently. I said we should scrap it entirely and introduce a Bank of England-style model, removing politicians from the decision-making process entirely.

Instead of ministers, an independent panel would make objective assessments of each export application, based solely on the risk to international law, free from any external interference, lobbying or personal prejudice.

Anything short of that, I argued, would allow a future Tory government simply to return to the old system, in a way they could never do on bank independence.

But my proposal met with resistance from some quarters.After all, some people like a bit of political subjectivity, so long as theyre the ones making the decisions - and especially if there are jobs at stake represented by our arms manufacturing unions.

I accepted a temporary compromise at the time, but vowed not to let it rest, and I wont do so under the new Labour leader.

Because if the last five years in Yemen have taught me anything - especially watching Tory ministers over that time - its the need to take other peoples power struggles out of our equations, and take politics entirely out of our arms trade. Only then can Britain conduct itself as an unequivocal force for peace.

The views expressed in this article belong to the author and do not necessarily reflect the editorial policy of Middle East Eye.

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UK and Yemen: The Catch-22 contortions of an unethical foreign policy - Middle East Eye

Clean living closer than you think at Cletas Nutrition – Alton Telegraph

Cletas Nutritions full-time sales consultant, Jennifer Rulo, left, store manager Wendi Wittman, center, and Wittmans mother and Cletas founder, Beverly Roberts, all of Godfrey, stand inside Cletas Nutrition, at 3004 Godfrey Road, in Godfrey. Roberts founded the health food store in 1991.

Cletas Nutritions full-time sales consultant, Jennifer Rulo, left, store manager Wendi Wittman, center, and Wittmans mother and Cletas founder, Beverly Roberts, all of Godfrey, stand inside

Cletas Nutritions full-time sales consultant, Jennifer Rulo, left, store manager Wendi Wittman, center, and Wittmans mother and Cletas founder, Beverly Roberts, all of Godfrey, stand inside Cletas Nutrition, at 3004 Godfrey Road, in Godfrey. Roberts founded the health food store in 1991.

Cletas Nutritions full-time sales consultant, Jennifer Rulo, left, store manager Wendi Wittman, center, and Wittmans mother and Cletas founder, Beverly Roberts, all of Godfrey, stand inside

Clean living closer than you think at Cletas Nutrition

GODFREY One of the regions most comprehensive health food destinations is right here in our own backyard.

Were the place you come to if you have a food intolerance, said Cletas Nutrition store manager Wendi Wittman. We have that edge. We carry and focus on what you would normally have to go to St. Louis to find.

Wittmans mother, Beverly Roberts, 75, founded Cletas Nutrition, in Godfrey, nearly three decades ago, at 3004 Godfrey Road, and still works at the health food store.

Wittman, 49, and knowledgeable full-time sales consultant, Jennifer Rulo, 46, research every single brand and product that is sold at Cletas Nutrition.

Rulo, a former customer, came to Cletas 12 years ago seeking pain relief. Not only did she find that relief often through trial and error but she also discovered a desire to help others find relief from persistent daily human conditions.

She is a blessing, said Roberts, who opened Cletas Nutrition in 1991.

Shes on it, shes into it, her hearts into health.

Rulo originally came to Cletas Nutrition to address her own fibromyalgia and inflammation. Now shes worked at Cletas for more than four years, helping others who walk through Cletas door to manage their own physical pain and fatigue.

I do a lot of one-on-one, Rulo said. People approach me about different things theres so many options. Theres a lot of different avenues as far as what people respond to we never diagnose or recommend, but talk about what has worked for other people and different research on pain management.

You have to know your companies and do your research to talk to others about clean products, she said, and you should always consult a physician before changing your diet or adding any supplements, especially with prescription medication.

Current diet trends include a ketogenic diet, high in fat, adequate in protein and low in carbohydrates, or plant-based, not necessarily vegetarian, consisting mostly, or entirely, of plant-derived foods, including vegetables, grains, nuts, seeds, legumes and fruits, and with few, or no, animal products. Diets that address food intolerance issues also are common, Rulo said.

Roberts began working in the health food and nutrition industry in the 1970s, for River City Nutrition, founded by Carl Muckler, who had an Alton location and three Missouri locations: Florissant, Chesterfield and Kirkwood, where Roberts worked. But her experience there wasnt the only thing that inspired her to have her own health food and nutrition business.

Different family members were getting sick and I was trying to think outside the box, about what could fuel the body so it could heal, Roberts recalled.

Now twice widowed, Roberts said health improved for her first and for her second husband when, during the course of their respective medical treatment, they began consuming clean foods and giving more attention to nutrition.

Clean means no chemicals, no dyes, no preservatives, no artificial or synthetic anything, explained Wittman.

In general, clean eating follows the belief that consuming whole foods in their most natural state and avoiding processed foods, such as refined sugar, offers certain health benefits.

For instance, organic ketchup has 45 percent more lycopene than commercial brands, Wittman noted.

Lycopene, a powerful antioxidant, can be found as a supplement, but it may be most effective when consumed from lycopene-rich foods, like, tomatoes. Lycopenes many health benefits purportedly include improved heart health and lower risk of certain types of cancer, as well as sun protection.

Roberts was diagnosed with lupus approximately three years ago, she said, and credits clean eating for reversing the systemic autoimmune disease, for which she no longer tests positive.

Within a year and a half, I tested negative, she said. God made the body to heal. In my recovery, I worked with diet changes, cleaning it up even more.

Cletas also offers healthy alternatives, such as homeopathic medicinal products, for mind and body, including beauty and hygiene products, such as fluoride-free toothpaste and hair and skin care.

Its nutrition for your outer organs, Wittman said.

Roberts gives all the credit for Cletas longevity to God.

Hes the reason, He has blessed our business, she said.

People come in here for so many things medically that may be irreversible, but you can clean up.

Visit Cletas Nutritions Facebook page for more information.

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Clean living closer than you think at Cletas Nutrition - Alton Telegraph

From Film to Fiction: Creating the Alien Franchises Literary Canon – Book Riot

I love the Alien franchise. Some people are Star Wars people, some are Star Trek people, me Im an Alien girl. Something about that perfect mix of science fiction and screaming bloody terrorit just works for me. But with only so many hours of film to watch, like any good fan Im always hungry for new content. And thankfully the Alien franchise has developed a significant literary canon to expand upon the film universe, so this Alien-hungry bookworm can keep on reading.

It make sense, really, that a franchise with such deep literary roots would make inroads into book publishing. Lovecraft, Conrad, Frankenstein, and of course the Prometheus mythos from which Frankenstein derives its own inspiration, have all informed the development of the series, from the original 1979 film to the most recent of Ridley Scotts prequels. Lovecraft is in the foundations of the original film, in its scope and its vast, apathetic universe that does not care if we live, or die screaming in the depths of space. And it wasnt until I had the chance to watch a recent documentary Memory, about the making of Alien, that I was introduced to the Conrad connection, and the influences of imperialism and colonization on the development of the films plot.

One of the reasons that the series has such longevity, one of the reasons it sticks with you, is that is has the same resonance as the works that have informed its creation. Alien has a mythic quality to it, built upon a framework of eternal themes and base human fears. Of course then, when it came time to expand the universe past the boundaries of the films, the franchise would make its way onto the printed page.

It started with novelization of the original film, Alien, at the hands of Alan Dean Foster, who has written every Alien film novelization since except for Alien: Resurrection (A.C. Crispin). He also wrote the prequel novel to Alien: Covenant,Alien: Covenant Origins, which came out late 2017 following the films May release. Novelizations are always worth reading because they are known for expanding upon the film being adapted, introducing new details and nuances that the demands of modern film runtimes have left on the cutting room floor. Foster in particular is known for his ability to take a film and spin it into a book that makes you feel like youre experiencing the story for the first time.

Since Fosters early contributions, the Alien canon has jumped the rails of film novelization and gone original. New stories, new characters and a few old favorites, new worlds, same old xenomorphs. In late 1992, after the release of Alien 3, Bantam books teamed up with author Steve Perry and started releasing new Alien novels, set in the same universe as the films but only tangentially related to them and referred to by the name of the second film, Aliens. This would eventual evolve into the first of three novel series, and involve several other talented authors, but it began with Perrys Aliens: Hive Earth. The first in a trilogy of novels, Aliens: Hive Earth introduced readers to Wilks and Billie, a battered, disenchanted ex-Colonial Marine and a young girl, the last survivor of a colony devastated by xenomorphs. Perry wrote the first two novels, Aliens: Hive Earth and Aliens: Nightmare Asylum solo, and co-authored the third book, Aliens: The Female War with daughter S.D. Perry.

These three books kicked off what ended up being a nine book run of novels from 1992 to 1998, five of which, excitingly enough, were written or co-authored by women, for whom a franchise with such a legendary female lead must have held a particular appeal. The second series of novels from 2005 to 2008 contained six books, and both novel series, most now out of print in their original format, have been combined into seven omnibusesThe Complete Alien Omnibuses 17by Titan Books in the last few years, giving new readers a chance to revisit these older Aliens adventures and nightmares.

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My introduction to the Alien franchises literary canon started with the third and most recent series of Alien novels. Specifically, Tim Lebbons excellent Alien: Out of the Shadows. I listened to the dramatized audiobook version before picking up a hard copy to read, and trust me the first time you hear a xeno hiss in your ear you will walk faster. Alien: Out of the Shadows is heart pounding. It also reunited me with my first love, Ripley, as Out of the Shadows and the two subsequent books, Alien: Sea of Sorrows (James A. Moore) and Alien: River of Pain (Christopher Golden), are interquels. All three books take place in the 53 year window between Ripleys sign off at the end of Alien, and her awakening and return to LV-426 in Aliens. Ripley makes appearances in books one and three, and book two features a slew of vengeful xenomorphs and one of Ripleys own descendants.

And thats just the beginning! Because the ongoing third series of novels is already eight books long. With more planned for the futurecourtesy of Titan Bookss loving cultivation of the Alien franchisethis series is set to overtake the first, ushering in a new wave of talented authors and new innovations on the canon. The later novels in the third series take place after Aliens, offering a secondary world view to that of the film canon and reintroducing readers to, among other things, the evil machinations of the omnipresent Weyland-Yutani Corporation.

Alex Whites Alien: The Cold Forgeand Tim Waggoners Alien: Prototype both deal with corporate espionage as Weyland-Yutani and its rivals vie for control of their most dangerous asset. Waggoners novel also introduces readers to former Colonial Marine (and general badass) Zula Hendricks, tying the novel canon into Brian Wood and Robert Careys gorgeous Aliens comic run with Dark Horse (Aliens: Defiance). As does Keith R.A. DeCandidos Alien: Isolation, which novelizes popular video game and the harrowing ordeal of Ripleys daughter Amanda on the crumbling Sevastopol Station. Amanda Ripley meets up with Zula Hendricks in Wood/Careys Aliens: Resistance, following the events of Alien: Isolation.

Titan Bookss most recent release (which they were kind enough to send me before it came out on February 25, thus not leaving me to languish in a desert of fandom deprivationand no theyre not paying me, I just really like their work and that they feed my obsession), Scott Siglers Aliens: Phalanx, is something entirely new: a spears and shields novel set in the Alien universe. A planet with a lost past and a people on the verge of extinction, besieged by vicious demons from the belly of a dormant volcano. In a lot of ways Aliens: Phalanx gave the impression a crossover novel between the usual hard sci-fi of Alien and something from a fantasy novel, and the epic battles between the spear wielding natives and the demons gives a the familiar conflict between humans and xenomorphs the feeling of something eternal. Something mythic.

Recently I had the opportunity to do something really cool: I was able to create questions about what it was like to write for the Alien franchise and send them to three of the authors who have recently contributed to Titan Bookss newest series of Alien novels. Tim Lebbon (Alien: Out of the Shadows), Scott Sigler (Aliens: Phalanx), and Keith R.A. Decandido (Alien: Isolation) were kind enough to send me some answers!

I was particularly interested in what the experience of creating within an extant canon was like, given that the Alien Universe is literally as vast as space itself. What is more, within this vast universe have already seen a number of innovative approaches to this overarching story of man vs. xenomorph, from the monster in the house narrative of the original to the military based adventures of the colonial marines or the invasion stories of distant colonies over run by the alien menace. So how do you create in a space that is simultaneously so limitless and limited?

Tim Lebbon had two different experiences as an Alien author. His first alien novel, Out of the Shadows,involved getting to work within the main story line of the franchise, and even to write a story Ripley herself, and involved timeline problems to overcome, and people and characters [he] could or couldnt kill. But he also describes there being quite a bit of freedom with the details of the story and the opportunity to create new, original characters as well. In his second alien novel (trilogy of novels, actually, the Rage War trilogy), however, Lebbon describes a much greater degree of freedom and the opportunity to imagine a whole area of the galaxy that had been explored and populated by humanity. [Its] scope was huge, and whilst featuring these two iconic creatures, it was also a space where [he] was allowed to develop their mythologies, and try to create an expanded world and story of [his] own. In probably one of my favorite anecdotes from this series of interviews, he wrote about how the cast of the Rage Wars trilogy was so huge that he had to ask his Facebook followers if they wanted to be horribly killed by xenos or predators in vast space battles. Naturally, they did.

Scott Sigler had some experience with the challenges of writing for the franchise before he startedPhalanx,because his story Dangerous Prey had been part of Jonathan Maberrys anthology Aliens: Bug Hunt. He describes the biggest challenges of writing Phalanx (which is an absolute brick of a book by the way, but you wont even notice the length once you get going!) as being the ones he created for himself, for instance by keeping the xenomorphs but removing the other great villain for the Alien franchise: the omnipresent Weyland-Yutani: Without the persistent Big Bad of WY (who is the true villain in almost all Alien stories) to drive the lying/manipulating/betraying plot angles, I forced myself to develop a structure that felt realistic yet still delivered some of the key elements that are inherent in a xenomorph tale. He also mentioned the difficulty of injecting new terror into a monster that people have seen many times now on the big screen and that has become something of a cultural icon. As he points out, even fans of mine that have never seen an Alien franchise movie know what a xenomorph looks like.

So if you get the chance to navigate the joys and sorrows of writing for a canon, how do you decide what story to tell? Who will your cast and lead characters be? Marines or Biologists? Colonists or Corporate Spies? Where will they be? Is it a clunking old ship on its last legs, a mining colony, or some lush distant planet full of exotic flora and fauna?

For Sigler, finding his story was a process. He worked with Titan Books editor Steve Saffel on a number of different potential plots and story ideas, ranging from cool heist stories to mercenary capers to tales of xenomorph evolution that strictly obey known biological practices. They finally settled on what would become Phalanx because the formula of spears and shields in space, and the innovative design of his setting, the far off Ataegina with its ancient-esque society, really stood out as something unique in the Alien universe.

For DeCandido, on the other hand, there was no selection processhis story was chosen for him. Fox wanted a novelization of the Alien: Isolation video game and he was approached by Titan Books for the project. Its an interesting counterpoint to Siglers selection process because it highlights how, when creating for an existing canon, there are stories that can be told, and stories that need to be told, and a balance that has to be struck between creators and parent companies. But while plot design was out of DeCandidos hands, he points out that the appeal of taking on the Alien: Isolation novelization was in part due to getting to write Amanda Ripley, who he describes as a fascinating and complex character who is as much her own person as she is the daughter of the legendary Ellen Ripley: Ive always been interested in consequences to actions, and what the ripple effects are of the big events that we tend to see, and what happens to those left behind or abandoned or whatever. We know what the consequences were to Ripley for not being found for decades between the first two movies, but in Isolation I got to focus on what the consequences were for those people she left behind, which was very appealing to me as a writer.

Aside from the joys and challenges of writing within an existing canon, and how to find the story you want to tell, I also wanted to know, with so many stories already being told, were there prior works in the franchise that particularly inspired you? And because your work cannot exist in a vacuum, separate from the rest of the canon, how do your works then come to be in conversations with all the novels that have come before you? Obviously Lebbon, Sigler, and DeCandido are all Alien fans from way back, influenced by the films that made such strong first impressions. All three agreed thatAlien, Aliens, or both were their favorite films of the franchise (not surprising given how many fans feel about the later films, she says sliding her beloved copies of Alien 3,Alien: Resurrection, and the prequels under the couch), acknowledging the influence of Alienss action-adventure storyline, and what Keith DeCandido referred to as Aliens portrayal of Space Longshoremen on a battered, broken-down old ship, which provided the template for this rather dank future, which set the stage for everything that followed.

For Lebbon, his novel Out of the Shadows is influenced most by Alien, with its claustrophobic atmosphere, establishment of a strong set of characters (some of whom we know from the off wont survive that next shadowy corner or stairwell) but he describes the Rage War trilogy as being as much a trilogy about the Colonial Marines as it is about the xenomorphs and predators and more of a tribute to Aliens militaristic action-adventure future. And Sigler considers his new novel Phalanx to be a logical extension of Alien and Aliens with a particular admiration for the the well-defined and highly plausible biological life cycle of the film Xenomorphs: While Phalanx doesnt run counter to the information presented in Alien III, Resurrection, Prometheus and Covenant, if fans of the first two films disagreed with the biology and storylines of the last four then those fans will likely groove on [Siglers] novel.

The last thing I wanted to know, with all the serious questions out of the way, was what hadnt I covered? What was the fun, or strange, or fascinating aspect of writing for the Alien Canon that we hadnt covered?

For Lebbon it was the research. He mentioned specifically all the research he put into space travel when writing the Rage War trilogy, and his quest for realism in futuristic transportation: I wanted to come up with something that was at least vaguely realistic. So theres no skipping to the other side of the galaxy in just a few minutes. Space travel takes time, and I came up with a neat network of transport hubs that enable the characters to jump between different points within the expanding sphere of the explored portion of the galaxy. Of course, any story like this set in deep spaceStar Wars, Trek, etcis going to play games with science, and thats pretty essential to serve the story. But it was a fun bit of research to do.

Siglers favorite part of his research was working with his many consultants to bring in real-world concepts that help ground the story and make it believable. For him, author Myke Coles nonfiction Legion vs. Phalanx was an integral text in bringing an original yet believable culture that emulates Summerian, Greek, Swiss and Scottish military strategies. He worked with Dr. Joseph Albietz III, MD, on human/xenomorph biological interaction, with fellow Alien Franchise author Alex White on a logical scientific build-out of the xenomorph form, and with Alien franchise experts Scott Middlebrook and Clara Fei-Fei arija to ensure that Phalanx was integrated into the existing Alien canon.

DeCandido was grateful for the chance to explore the character of Ellen Ripley through her daughter, Through flashbacks to Amandas childhood, as well as Amandas own reading of some old reports from one of Ellens pre-Nostromo gigs which enabled him to dig deeper into the back story of one of science fictions most compelling characters [] getting to write her and flesh her out was a great honor and tremendous fun.

I could not be more excited about where the Alien franchise is going (and, of course, about the possibility of new content). In fact, my only disappointment thus far with this new series of Alien novels is that weve gone from five in nine books authored or at least co-authored by women, to zero in eight.

We have had one Alien book written by a women in 2019, and I adored Mira Grants Alien: Echo. Im not downplaying its contribution at all! But as a YA novel produced by a Macmillan imprint rather than by Titan Books, the Echo exists outside of the exciting, ongoing canon that Titan Books is building with each new novel. So heres hoping well see not only a sequel to Grants novel (please, Macmillan, I need it), but also a number of new, talented women writers joining the Titan Books Alien ranks in the years to come!

Yes, the future of Alien franchise novels looks as bright as a set of silver teeth in a dark corridor. If you need me Ill be making space on my bookshelves.

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From Film to Fiction: Creating the Alien Franchises Literary Canon - Book Riot

The Beckwith Blog: In the Eye of the Storm! – National Mortgage Professional Magazine

Here I am, sitting at a rented lake house in central New Hampshire, in my hometown from my childhood. Its a Friday morning and I am in the rare place to have my folks and siblings be able to drop by for a visit. I am home for a birthday party weekend for yours truly, my a-hem (insert cough) 50th, I mean 39th Birthday. I am feeling nostalgic now so writing my Blog for this month feels a little melancholy, but with that said, I want to provide value at a time I know you will be reading this over the holidays. This time of year breeds a long-awaited pause or slowing for everyone in our field, a welcomed one for a year that gifted us with lower rates and lots of volume for those who dialed in and worked hard.

Over the prior six months, I have traveled across the nation, truly, to incredible conventions, to speaking gigs and events, too many to mention, and along the way, I found myself amid others doing the same. Professionals who, by and large, were trying to grab market share, sling their product and of course, connect with new opportunities. That said, in the midst of this storm, I began to watch and absorb the true magnitude of the chaos and rapid-fire environment that would represent the greatest year and closest thing to a return to our prior great market years that had been experienced in over a decade.

So, what did I learn? Living in the Eye of the Storm is quite incredible. I learned that at the core of our human spirit lives a desire for people to join forces, to come together, to laugh, to help one another and to truly support each others businesses. I learned that you can consistently travel for a dozen straight weeks at a time, run a business, pack and unpack, show up in stellar mode, perform and check the box until the next stop. A rock star life ensued for me this year, while trying to maintain some form of normalcy at the home front, stopping home for four days in-between to do kids activities, home activities, personal accounting, family time, sports and God willing, a little rest. As the weeks would wear on this year though the faade and glamour of the mortgage industry convention circuit, I would have some of the most incredible and tender moments that you can only recognize as powerful in hindsight.

1. Networking is still in our new age of technology, is the greatest way to form relationships that lead to long-term business: There was no greater ROI on any other marketing avenue than this for me this year. It is and has been the tried and true way to cultivate, vet and grab market share.

Personal lesson: There are the most beautiful souls out there in our business who are filled with the entrepreneurial spirit people who I know will change the landscape of our tomorrows in this industry. I also fell in love with those OG mortgage professionals who are still evolving and re-defining themselves in a new era and there are many!2. Technology is at the top of everyone lists: The mortgage industry wants to evolve into a more mobile and automated world. I heard, in many conventions, the quotes of ancient systems and dinosaur ages when describing our technical world here and how its truly time for evolution. People seemed to be listening. I certainly was and I am excited for once to see where this goes.Personal lesson: Instead of cringing about the need for technology I did not welcome, I could see even my own sentiment on this topic had changed. Listening to so many rooms on this topic, I can see people are embracing this era and time. We will see evolution in this area in the years ahead finally.3. PC is so yesterdays news: No matter what surrounds the mortgage industry and all of its many minute details, at the core of our existence remains the human experience and what seemed to jump off the pages of social media this year was the more personal stories of homeownership successes, businesses successes and authentic story-telling from human-minded messages from the B2B entrepreneurs are now filling our space. Those companies that continue an aesthetic-minded approach to their social media might as well throw their money out the window of their moving car.Personal lesson: I say Thank God! I dont know how else to be but real, raw and authentic, I am grateful it is in style this year.4. No more fake news: Its now time for everyone to listen to the entrepreneurs. Our salesfolks, the loan originators, brokers and front-line men and women are where the real news lies. These folks are taking to their social media outlets, videos in hand, and are letting us know what is real or not real. Its beautiful and it trumps (pun intended) the contrived news stories paid for by commercialized news-telling. I write for this magazine and many others that I know do diligence to their news-telling and this is not intended to be a slam to that format, I think those news companies who are employing a story-telling philosophy and bringing the voices of those people to their pages, podcasts and stories, its the smartest thing they could have done.Personal lesson: Me and my organization are the real deal, and I run with a real deal crew. Get real its the best advice I can give you.5. Life is short, in business and for real: To live a long life in the mortgage profession, which I have somehow accomplished, staying put is not an easy task. I wrote an article in early 2018 about staying in a Safe Seat of musical chairs and gave advice. That advice was never more poignant than this year when the grass is greener philosophy and the waving of company flags were being shaken harder than ever before. Volume would be the glue that kept loan officers in their seats and many business development managers found themselves in the hot seats trying to explain slow recruiting because nobody who wasnt suffering truly where they were was moving. For many mortgage professionals, their homes seem short-lived. The life of the mortgage originators job or longevity with a firm, has been truly shortened this past year and movement has been an acceptable thing that hiring firms have learned to accept on resumes that show lots of past employers. That is changing. Everyone is getting into their Happily Ever After Seats for the next decade and living their lives in their best way.Personal lesson: After watching three of my family members weather terminal illnesses, I truly have accepted the shortness of our lives and careers. In the past two years, I have left a firm I worked at for 12 years and started my own company. I turned 50 as I said at the start of this article and I am realizing time is a precious commodity. So, my advice here is simply that we must live our best life and our absolute most genuine life.Time is of the essence and I think everyone should be operating with the ideology of that every single day. There is no greater piece of advice I can offer to people. I hope you heed this advice.In ending this short Blog, I offer that living in the Eye of the Storm this year was beautiful, meaningful, rich in relationship and experience, rewarding and quite frankly far more compelling than sitting on the sidelines. I would highly recommend that you all get out there, out of your seats and out of your comfort zones and get into the mix. There is beauty in the buzz. Be part of the buzz. I feel like this year, I became part of the buzz. I like it. Long live the storm!

This article originally appeared in the November 2019 print edition of National Mortgage Professional Magazine.

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The Beckwith Blog: In the Eye of the Storm! - National Mortgage Professional Magazine

Token Economics: In The Long Run, Decentralization Will Survive – Traders Magazine

Money exists to serve a fundamental purpose as a medium of exchange for goods and services. A central authority designates a certain currency as legal tender and people can proceed to trade with it, trusting in its function as a unit of account and a store of value. Simply put, the traditional system of money thus far has revolved around four main participants: governments, central banks, intermediary banks, and users of money. Its a system that has been built over centuriesone not easily dismantled or replaced, as significant cost and physical infrastructure has been put into supporting its integrity and performance.

Changing the game

Relatively speaking, traditional money and the financial system it runs on have weathered much of the digital revolution unscathed. Rather than changing to fit the times, digital technology has been integrated around the usual way banks and financial institutions function, leaving the underlying fundamentals of the system untouched, along with its inherent inefficiencies and costliness. To say that legacy finance is now under threat, however, might be to jump the gun; nevertheless, we can see some challengers to the status quo emerging, as technology advances and becomes a more pervasive part of human life.

Cryptocurrencies have been lauded as one of the biggest game-changers within the centralized system of banking and finance. With the distributed ledger that underpins cryptocurrency, decentralization and disintermediation is made possible, and instead of a centralized entity validating transactions, the process is distributed across a network of validators. In a truly decentralized financial system, the middlemen and their fees are cut out, while the speed and efficiency of transactions are greatly improved. Clearly, such a system would be able to directly challenge the function and use of the traditional financial order.

Good governance and incentivization

While the technical aspects of cryptocurrency and distributed ledger technology have moved beyond theoretical whitepapers and into real-world applications, relatively little attention has been paid to the economic relevance of cryptocurrencies and the forces that govern the price and value of digital assets. Called cryptonomics, tokenomics, or just token economics, this field of study focuses on how incentivization and validation is used to encourage token adoption and subsequent ecosystem building around that token. While the utility of fiat currencies is largely limited to exchange and trade, crypto tokens can be put into service in a myriad of ways, and token economics explores the use cases of digital assets beyond their utility as currency.

There is so much to unpack when trying to understand the forces that govern functioning crypto ecosystems. Crucial issues, such as the incentives for blockchain participants to cheat or the endogenous value of a token in exchange, are still poorly understood and yet are pivotal to understanding the optimal design for a mainstream blockchain-based form of payment. How should a system be built to reinforce desirable behaviors amongst users, while discouraging cheating and market manipulation? Any platform looking for longevity and sustainability in a fast-changing industry must ask this question first and foremost. Currently, most cryptocurrency platforms incentivize users to perform governance decisions by awarding them newly-mined cryptocurrencies. They manage the rate at which new units are created to keep the supply of available tokens in check; therefore, the total amount of currency in the system is limited by the protocols written by the creator of the blockchain. Having these limits in place creates an impression of scarcity amongst users that allows the system to maintain the value of the crypto token.

Breaking the rules

It is this quality of scarcity that breaks the rules of inflation that already govern legacy money standards. Under the forces of inflation, the power of money to buy the same basket of goods is expected to be less in the future compared to today. These same forces do not have to apply to cryptocurrencies; not when they offer an opportunity for monetary experimentation and the potential for new ways of managing monetary supplies. Major platforms like Ethereum place community governance of token supply at a higher priority to maintain the ethics of a decentralized system, while privatized foundations of cryptocurrencies like Binance and VeChain use coin burning techniques to limit supply and temporarily increase the value of tokens. Essentially, the supply and value of a given digital asset is dependent upon the participants of the network and the algorithm it is built on, which places cryptocurrencies largely outside of the influence of geopolitical flux that otherwise affects traditional markets. For this reason, people from Venezuela and Argentinaboth countries experiencing hyperinflationare putting their money into bitcoin and other digital assets to hedge against the risk of inflation in the traditional market.

As the industry moves on from the crypto hype and market correction of the past, it has become clear that decentralized finance holds incredible potential for the global financial and economic system. The technology is constantly evolving, but sound principles of business and a strong token-flow model are more necessary than ever to keep the industry sustainable in the long-run, particularly in the face of tightening global regulations on crypto tokens and exchanges. Governance, incentivization, revenue sharing, and accessibility are all crucial metrics to consider before building an economic model for digital tokens and cryptocurrencies.

In the coming years, we can anticipate a future where both tangible and intangible assets are tokenized and easily used in real-time transactions on decentralized platforms and exchanges. We are on the precipice of a new global economy, one that is undergoing massive transformation. The steady development of decentralized finance, regulatory clarity, crypto-specific taxation policies, and central bank digital currencies are all positive steps towards shaping the new financial ecosystema decentralized token economy characterized by greater accessibility to financial services, safer transactions, and lower transaction costs. With full decentralization on the horizon, its becoming apparent that the face of global finance will never be the same again.

Neeraj Khandelwal is Co-founder of CoinDCX, Indias largest cryptocurrency exchange

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Token Economics: In The Long Run, Decentralization Will Survive - Traders Magazine

16 Style Essentials You Should Have at Home – gearpatrol.com

Style starts at the home before you go to bed when you moisturize your face, in the shower after you wake up and when you go to your closet to choose your outfit. It happens outside of work hours when your shoes need some TLC or a button needs sewing. Little upgrades here and there can set you up for the day and the right tools can keep your style going for much longer. For that, weve put together this list of style essentials for the home, from head to toe.

First things first: be gentle on your clothes. Use a detergent thats mild and easy on your clothes. While we like our fragrances and cant deny that the smell of laundry is objectively good, save the perfumes for your person and not your clothes.

This goes for the drying cycle, too. It may take more time to air dry your clothes, but that time you put in pays dividends on your clothes longevity (not to mention the Earth).

Once your garments are clean and dry, make sure to hang them up with a good hanger. Avoid the flimsy, thin plastic ones if you can. Clothes are made to hang on a human body (which is three-dimensional). When theyre not on you, they should be hung on a hanger with wider shoulders, lest you want your clothes to slowly deform and lose shape over time. Hangers made from cedar wood help to defend your clothes from moths, so opt for these if you can.

Nobody wants to see a wrinkled shirt. Invest in an iron, especially if the occasion is meeting with investors or your future in-laws.

For the love of Ralph Lauren, do not try to iron your clothes on your bed or coffee table. Invest in an ironing board, preferably one that has a rack to hold your iron.

Steaming your clothes in the shower does not work. Its good for wasting water and developing black mold in your bathroom. Instead, get an actual steamer that will quickly and effectively get those wrinkles out.

Your clothes will eventually need some tune-ups. Plus, learning to sew and mend clothes is a skill you should know since home ec isnt really a thing anymore.

After a good bath soak replete with bubbles, surrounded by candles and meditative tunes, maintaining your leather shoes is the next most-relaxing thing. For that, start with some leather soap like this one.

Once youve cleaned your shoes, make sure to condition them with some leather lotion or oil. Its just like the shower.

Oh, and before you go to town on your shoe care regimen, make sure youre using the proper tools.

Lint happens. Rather than using lint rollers that you constantly have to refill, try a reusable lint brush.

Now lets shift the focus to you. Unless youre going for a world record, keep your nails trimmed and neat.

Taming a mane, trimming the hedges or having a Britney Spears moment, an electric trimmer is there for you.

For those who are deft with scissors to do some mane maintenance, a solid pair of grooming scissors stretches your dollar more than trips to the barber.

Like treating and caring for your clothes, you want to be gentle on your skin, too. Try a soap for sensitive skin thats free of scents and harsh ingredients.

Even the most gentle soap can wash away some of your skins natural oils. Follow up the wash with a good lotion to prevent dry skin and keep your natural moisture barrier intact.

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16 Style Essentials You Should Have at Home - gearpatrol.com