Covid-19: Crowdsourced virtual supercomputer revs up virus research – The Star Online

WASHINGTON: Gamers, bitcoin miners and companies large and small have teamed up for an unprecedented data-crunching effort that aims to harness idle computing power to accelerate research for a coronavirus treatment.

The project led by computational biologists has effectively created the world's most powerful supercomputer that can handle trillions of calculations needed to understand the structure of the virus.

More than 400,000 users downloaded the application in the past two weeks from Folding@Home, according to director Greg Bowman, a professor of biochemistry and molecular biophysics at Washington University in St. Louis, where the project is based.

The distributed computing effort ties together thousands of devices to create a virtual supercomputer.

The project originally launched at Stanford University 20 years ago was designed to use crowdsourced computing power for simulations to better understand diseases, especially protein folding anomalies that can make pathogens deadly.

The simulations allow us to watch how every atom moves throughout time, Bowman told AFP.

The massive analysis looks for pockets or holes in the virus where a drug can be squeezed in.

Our primary objective is to hunt for binding sites for therapeutics, Bowman said.

Druggable targets

The powerful computing effort can test potential drug therapies, a technique known as computational drug design.

Bowman said he is optimistic about this effort because the team previously found a druggable target in the Ebola virus and because Covid-19 is structurally similar to the SARS virus which has been the subject of many studies.

The best opportunity for the near-term future is if we can find an existing drug that can bind to one of these sites, he said.

If that happens it could be used right away.

This is likely to include drugs like the antimalarials chloroquine and hydroxychloroquine which may be repurposed for Covid-19.

Bowman said the project has been able to boost its power to some 400 petaflops with each petaflop having a capacity to carry out one quadrillion calculations per second or three times more powerful than the world's top supercomputers.

Other supercomputers are also working in parallel. The Oak Ridge National Laboratory said earlier this month that by using IBM's most powerful supercomputer it had identified 77 potential compounds that could bind to the main spike protein of the coronavirus to disarm the pathogen.

No end to compute power

The Folding@Home project is fueled by crowdsourced computing power from people's desktops, laptops and even PlayStation consoles, as well as more powerful business computers and servers.

There is no end to the compute power than we can use in principle, Bowman said. Large tech firms including Microsoft-owned GitHub are also participating, and the project is in discussions with others.

Anyone with a relatively recent computer can contribute by installing a program which downloads a small amount of data for analysis.

People can choose which disease they wish to work on.

It's like bitcoin mining, but in the service of humanity, said Quentin Rhoads-Herrera of the security firm Critical Start, which has provided its powerful password hash cracker computer designed to decrypt passwords to the project.

Rhoads-Herrera said his team of security researchers, sometimes described as white hat hackers, were encouraging more people to get involved.

Fighting helplessness

Computer chipmaker Nvidia, which makes powerful graphics processors for gaming devices, called on gamers to join the effort as well.

The response has been record-breaking, with tens of thousands of new users joining, said Nvidia spokesman Hector Marinez.

One of the largest contributions comes from a Reddit group of PC enthusiasts and gamers which has some 24,000 members participating.

It is a fantastic weapon against the feeling of helplessness, said Pedro Valadas, a lawyer in Portugal who heads the Reddit community and is a part of the project's advisory board.

The fact that anyone, at home, with a computer, can play a role and help fight against (disease) for the common good is a powerful statement, Valadas told AFP. AFP

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Coronavirus And Folding@Home; More On How Your Computer Helps Medical Research – Hackaday

On Wednesday morning we asked the Hackaday community to donate their extra computer cycles for Coronavirus research. On Thursday morning the number of people contributing to Team Hackaday had doubled, and on Friday it had doubled again. Thank you for putting those computers to work in pursuit of drug therapies for COVID-19.

Im writing today for two reasons, we want to keep up this trend, and also answer some of the most common questions out there. Folding@Home (FAH) is an initiative that simulates proteins associated with several diseases, searching for indicators that will help medical researchers identify treatments. These are complex problems and your efforts right now are incredibly important to finding treatments faster. FAH loads the research pipeline, generating a data set that researchers can then follow in every step of the process, from identifying which chemical compounds may be effective and how to deliver them, to testing they hypothesis and moving toward human trials.

First, heres the rundown on how easy it is to set your computer up to help with Folding@Homes Coronavirus effort:

Okay, lets answer some questions! First up, does this actually make a difference?

The Folding@Home project started back in 2000. Much has been accomplished over the course of the past 20 years and I encourage you to go and read the lengthy Examples of application in biomedical research section of the Wikipedia page which takes an in-depth look at the impacts.

The effort has identified drug therapies for Alzheimers and Huntingtons diseases, its been used in drug design for combating HIV and influenza (both are viral), and is used to study how cancer mutates. Now we have the chance to apply that to the COVID-19 virus. On an explain-it-like-Im-five level, scientists are trying to simulate every possible combination of protein folding patterns, looking for locations that would let medicine grab hold and do some good.

Its a huge challenge, similar to trying every combination on a padlock, but this lock takes a mind-bogglingly large number of combinations. Research scientists highlight where the most likely solutions lie, then use the mind-bogglingly huge power of the Folding@Home network and sets to work running the simulations. How powerful is the FAH network? Wikipedia lists it at 470 petaFLOPS as of early March 2020 which means 416 quadrillion floating point operations per second. Thats 416 million billion math problems solved every second!

But heres the best part of all of this, the project is non-profit and makes the data freely available to other researchers upon request.

No, but you dont need to since the group is already prioritizing the coronavirus effort. Although the software does offer the option to work on a specific area of research, COVID-19 is not specifically listed. That is likely because this pandemic is fast moving and its not worth trying to push a new version of the software just to add this setting. For now, leave this on the default of Any and your computer will work on COVID-19 whenever there are Work Units (WU) available.

You can use the built-in web interface found at http://localhost:7396/ to see what problem your computer is currently working on. Here you can see the Learn more screen from currently running instance. This week I have only seen one time that my computer was working on a different project.

The FAH servers dish out those WUs as fast as they can, but right now the network is growing as more people add their computers to the network. When all of the staged WUs run out, your computer will be idle until more become available. This has nothing to do with you, project maintainers are working to keep this buffer full.

Im not an expert but I believe the answer is that this research seeks to identify pharmaceutical treatments and a better understanding of how the protiens in the virus work. This is not necessarily in pursuit of a vaccine.

This is still incredibly important, it means that researchers are looking for drugs that can be used to treat patients who have the virus. Right now, COVID-19 is really good at evading our bodys natural defenses our immune system. If drug therapies are discovered that weaken the virus, it may lead to our immune system having a foothold to fight the infection.

We need both a vaccine and drug therapies consider the example of the seasonal flu where we have vaccines to protect people from infection and antiviral drugs to treat at-risk populations who have been infected. Research into both should be, and is, running in parallel.

This effort is gamified, so join your fellow hackers on Team Hackaday by using team #44851 when you configure your Folding@Home software. When we first published, we had 21 active team members, by Friday afternoon there were 737. Can we make that 7000 by the end of the week?

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Coronavirus And Folding@Home; More On How Your Computer Helps Medical Research - Hackaday

Crowdsourced supercomputing project sets sights on coronavirus – Washington University School of Medicine in St. Louis

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Folding@home targets COVID-19, number of volunteer folders skyrockets

Shown is the first look at the Folding@home project's simulations of the COVID-19 spike protein. The three colors represent components of the spike protein; this is the protein that the novel coronavirus uses to infect cells. The site where the protein binds to human cells, to infect them, is on the top of the protein. Using Folding@home, the researchers are aiming to develop an accurate picture of what happens during infection. Understanding these details could help reveal ways to block the virus from infecting cells.

People around the world are isolating themselves to help slow the spread of COVID-19. But there is another way those confined to their homes but connected online can join the fight against the novel coronavirus. Among the research programs racing to develop therapies and vaccines for this new pandemic virus is one of the largest crowdsourced supercomputing projects in the world.

Led by computational biophysicist Greg Bowman, PhD, an associate professor of biochemistry and molecular biophysics at Washington University School of Medicine in St. Louis, the project is called Folding@home. It relies on the collective power of volunteers home computers to perform the complex calculations required to simulate protein dynamics.

Volunteers from all over the world can install a software program that runs those calculations when a computer otherwise would sit idle. Often motivated by personal experience with various diseases, the participants get to select an area of contribution, such as boosting cancer research, preventing Alzheimers disease or now fighting the novel coronavirus.

For example, Bowman and his team are trying to understand the structure of COVID-19s spike protein, which is what the virus uses to infect cells. Such research could reveal ways to block the protein and, consequently, infection. Since announcing in late February the projects new focus on coronavirus, the number of Folding@home volunteers has skyrocketed, with some 400,000 new folders joining the effort, Bowman said.

The response so far has been overwhelming and wonderful, but there is always more useful science to be done, he said. Understanding all the various shapes that the spike protein can take on as its molecules bounce and shift can lead to the development of new drugs that can block it, stopping the virus from infecting more cells. We are continuing to scale up our research as fast as we can.

Bowman has shared what could be thought of as a first glimpse of the moving COVID-19 spike protein. It consists of three different proteins that fit together like a 3D puzzle. The simulation reveals a pocket that helps the virus bind to human cells and infect them.

In the spirit of open science and the rapid sharing of new knowledge about COVID-19, Bowman said the research team will publish findings on free and open-access preprint sites, such as bioRxiv.

To join the effort and put your computer to work against coronavirus, visit https://foldingathome.org.

Washington University School of Medicines 1,500 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Childrens hospitals. The School of Medicine is a leader in medical research, teaching and patient care, ranking among the top 10 medical schools in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked to BJC HealthCare.

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Crowdsourced supercomputing project sets sights on coronavirus - Washington University School of Medicine in St. Louis

Thousands of These Computers Were Mining Cryptocurrency. Now They’re Working on Coronavirus Research – CoinDesk – Coindesk

CoreWeave, the largest U.S. miner on the Ethereum blockchain, is redirecting the processing power of 6,000 specialized computer chips toward research to find a therapy for the coronavirus.

These graphics processing units (GPUs) will be pointed toward Stanford University's Folding@home, a long-standing research effort that unveiled a project on Feb. 27 specifically to boost coronavirus research by way of a unique approach to developing pharmaceutical drugs: connecting thousands of computers from around the world to form a distributed supercomputer for disease research.

CoreWeave co-founder and Chief Technology Officer (CTO) Brian Venturo said the project has at least a shot at finding a drug for the virus. As such, CoreWeave has responded by doubling the power of the entire network with its GPUs, which are designed to handle repetitive calculations.

According to Venturo, those 6,000 GPUs made up about 0.2 percent of Ethereum's total hashrate, earning roughly 28 ETH per day, worth about $3,600 at press time.

There is no cure for the coronavirus just yet (though various groups are working on vaccines and research to combat the disease, including IBM's supercomputer). Venturo noted that Folding@home has been used to contribute to breakthroughs in the creation of other important drugs.

"Their research had profound impacts on the development of front-line HIV defense drugs, and we are hoping our [computing power] will aid in the fight against coronavirus," Venturo said.

The coronavirus is taking a toll across the world. Italy and Spain are on lockdown. Conferences, stores and restaurants are closing to stem the spread of the disease; by stoking fears, it's slamming the financial markets in the process.

World computer

When the idea of using GPUs for coronavirus research was mentioned to CoreWeave, the team didn't think twice.

They had a test system up and running "within minutes," Venturo said. Since then, the project quickly snowballed. CoreWeave has been contributing over half of the overall computing power going into the coronavirus wing of Folding@home.

"The idea of 'should we do this?' was never really brought up, it kind of just happened. We were all enthusiastic that we might be able to help," Venturo added.

Folding@home is a decentralized project in the same vein as Bitcoin. Instead of one research firm alone using a massive computer to do research, Folding@home uses the computing power of anyone who wants to participate from around the world even if it's just a single laptop with a little unused computing power to spare.

In this case, the computing power is used to find helpful information relating to the coronavirus. Much like in bitcoin mining, one user might detect a "solution" to the problem at hand, distributing this information to the rest of the group.

"Their protein simulations attempt to find potential 'pockets' where existing [U.S. federal agency Food and Drug Administration (FDA)] approved drugs or other known compounds could help inhibit or treat the virus," Venturo said.

Viruses have proteins "that they use to suppress our immune systems and reproduce themselves. To help tackle coronavirus, we want to understand how these viral proteins work and how we can design therapeutics to stop them," a Folding@home blog post explains.

Simulating these proteins and then looking at them from different angles helps scientists to understand them better, with the potential of finding an antidote. Computers accelerate this process by shuffling through the variations very quickly.

"Our specialty is in using computer simulations to understand proteins moving parts. Watching how the atoms in a protein move relative to one another is important because it captures valuable information that is inaccessible by any other means," the post reads.

Long shot

Folding@home could use even more power. Venturo urges other GPU miners to join the cause.

Even without these calls for participation, though, miners of other cryptocurrencies are already independently taking action. Tulip.tools founder Johann Tanzer put out a call to action to Tezos bakers (that blockchains equivalent of miners) last week, promising to send the leading contributor to Folding@home a modest 15 XTZ, worth roughly $20 at press time.

The initiative blew up, to Tanzer's surprise. Though they might not be contributing as much power as CoreWeave, 20 groups of Tezos miners are now contributing a slice of their hashing power to the cause. Tanzer's pot has swelled to roughly $600 as Tezos users caught wind of the effort and donated.

But that's not to say all miners can participate. While GPUs are flexible, application-specific integrated circuits (ASICs), a type of chip designed specifically for mining, aren't, according to Venturo. Though ASICs are more powerful than GPUs, they're really only made for one thing: To mine cryptocurrency. This is one advantage Venturo thinks Ethereum has over Bitcoin, since GPU mining still works on the former, whereas the latter is now dominated by ASICs.

"This is one of the great things about the Ethereum mining ecosystem, it's basically the largest GPU compute resource on the planet. We were able to redeploy our hardware to help fight a global pandemic in minutes," Venturo said. (However, it's worth noting that Ethereum has seen ASICs enter the fray. Not to mention, ether miners might soon go extinct when a pivotal upgrade makes its way into the network.)

ASICs are useless for the Folding@Home effort, but if bitcoin miners have old GPUs lying around from the early days that they could contribute, too.

Even if other miners join up, though, it's still a long shot that the effort will lead to a helpful drug.

"After discussing with some industry experts [...] we believe the chance of success in utilizing the work done on Folding@Home to deliver a drug to market to be in the 2-5% range," Venturo said.

The leader in blockchain news, CoinDesk is a media outlet that strives for the highest journalistic standards and abides by a strict set of editorial policies. CoinDesk is an independent operating subsidiary of Digital Currency Group, which invests in cryptocurrencies and blockchain startups.

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How Ethereum Mining Rigs Can Help Battle the Coronavirus – Live Bitcoin News

Several cryptocurrency mining projects particularly those devoted to extracting new Ethereum tokens have been pulled away from their mining duties and been made to turn their attention towards coronavirus research.

The coronavirus was recently declared a global pandemic by the World Health Organization (WHO). As many as 245,000 people have been infected with the virus at the time of writing, while more than 11,000 deaths across the globe have been recorded.

Recently, world leaders such as President Donald Trump in the United States have declared a national emergency, while the governors of both California and New York have issued stay at home orders, asking that residents stay within their domiciles and limit their outdoor activities with others to stop the virus spread.

At this time, it seems like people need all the help they can get, and research regarding how to combat the virus is at an all-time high, but how, exactly, can crypto mining rigs help to get this done?

Its not so much that they help with the research aspect, but what they do have is high computational power enough so that the computers and devices conducting or holding present research can stay operational and functional during these stressing times, and its here where the mining rigs can serve great purpose.

Among the major companies working to better understand the problems and symptoms associated with the growing respiratory virus is Stanford Universitys Folding @home, which helps to develop therapeutic drugs. As recently as last month, the company was devoting much of its time, energy and resources towards establishing drugs and products designed to combat HIV, but now, it has shifted focus to work on coronavirus research.

One of the main things that Folding @home does is sort through protein structures of products approved by the Food and Drug Administration (FDA). Proteins, depending on how theyre built, can lessen a disease or even fully treat it, and the venture is looking to see which proteins are available that could potentially bring the virus to its knees.

In a statement, the company explains:

Proteins have lots of moving parts, so we really want to see the protein in action. The structures we cant see experimentally may be the key to discovering a new therapeutic.

Right now, Folding @home and several other drug-related companies are getting their power from sources such as Core Weave, which is one of the largest Ethereum mining projects in the rural United States. At press time, Core Weave is dedicating mountains of computational power to these companies to assist in their time spend performing appropriate research.

The mining venture stated:

Core Weave is proud to support this effort with over 6,000 of our high-end GPUs.

As many as 20 separate companies are presently working on a coronavirus vaccine.

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Creative Technology dedicates the processing power capacity of its media servers to scientific research to fight covid-19 disease. – EtNow.com

UK Creative Technology (CT) UK is home to hundreds of media servers, each with the latest in GPUs and processors. Ordinarily, these servers are key to delivering live events for clients, but following the outbreak of COVID-19 throughout Europe and beyond, and the related reduction in live events, CT has found itself in a position to get really creative with the technology. Fighting back against Coronavirus in the best way known, and this comes in the form of the Folding@Home project run by Stanford University.

CT London has set up a server farm, doing all it can to support this worthwhile project.

Researchers from all over the world can now use the CPU (Central Processing Unit) and GPU (Graphic Processing Unit) capacity of the media servers to draw, calculate and analyse complex formulas and graphics in the global fight against COVID-19.

Folding@Home is a distributed computing project for disease research that simulates protein folding, computational drug design, and other types of molecular dynamics. These scientific COVID-19 projects focus on better understanding how these Coronaviruses interact with the human ACE2 receptor required for viral entry into human host cells, and how researchers might be able to interfere with them through the design of new therapeutic antibodies or small molecules that might disrupt their interaction. There is hope to take advantage of some of the new structural biology and biochemical data that is being rapidly released by researchers around the world who are working to understand these viruses and strategies for defeating them.

Since joining the Folding at Home Project, CT announces that several other NEP Group companies have also got on-board: Screenworks, Univate, and Bexel to name just a few.

Creative Technology Group is urging all companies in the audiovisual sector to join this project by making their processing power also available for scientific purposes. Researchers are especially in need of more high-spec GPUs to help, and all the GPU projects are devoted to potential drug targets for COVID-19 right now.

Help to fight COVID-19 by joining this worldwide distributed supercomputer. Please use the Creative Technology group number 240907 to contribute your capacity to its team. You can help by downloading the Folding@Home client to your computer and following the instructions to install it.

CT cant make ventilators, but it CAN fight COVID-19!

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Creative Technology dedicates the processing power capacity of its media servers to scientific research to fight covid-19 disease. - EtNow.com

Journaling during the pandemic, for yourself and the historians – The Boston Globe

As people across the country are told to work from home and practice social distancing, historians recommend a simple practice to fend off boredom and contribute to the history books: daily journaling.

Written accounts of events, especially during times of turmoil, have proven crucial to historians as they seek to grasp a full picture of a time period. And during the current pandemic, physical documentation from ordinary people is as important as ever.

As historians, we rely on those daily reports to figure out what actually happened on the ground, said Victoria Cain, an associate professor of history at Northeastern University. It really offers us insight into how society and culture worked at a time of tragedy, or crisis, or just chaos.

Personal journals helped capture the struggles and horrors of history. The Great Plague of London was documented by Daniel Defoe, drawing on his own childhood memories, his uncles journal, and extensive research. And generations have learned of the horrors of World War ll through the experiences of Anne Frank.

However, in the age of social media, virtual writing has taken precedence over pen and paper. Photographs, e-mails, and text messages may document the essence of an era, but their longevity could be limited.

Digital media and technology is amazing in many ways, but it also has a lot of problems, said Dan Cohen, the dean of libraries at Northeastern University, whose extensive documentation of firsthand accounts following the Sept. 11 attacks is in the Library of Congress. A physical diary, if you stick it in your attic, youll likely be able to read that in a century or two. That really doesnt happen with digital media.

In some instances, the physical documentation can tell a story itself. While Cain was completing her doctoral dissertation years ago, she recalls analyzing the diary of a naturalist who was sent to France during World War l. As she was reading, she began to cry.

You can see his handwriting, and hes scared hes going to die, she said. Theres teardrops on the page, and the ink is running. I remember being in the archives I started crying, and Ill never forget that experience.

Cain and Cohen stressed the benefits that not only for historians but also for the writers; the act of putting pen to paper has been found to bring certain therapeutic benefits.

It helps to contextualize [the event] and put it into a longer time horizon, Cohen said. That can kind of help to lower the blood pressure a little bit.

I think it just helps us slow down and reflect a little bit about what extraordinary times these are, Cain said.

Caeli Chesin, a junior at the University of Massachusetts Amherst, described her experience with journaling during the pandemic as cathartic.

As much as we are locked in and nervous, I think there is a lot of potential to use the time to connect with loved ones, slow down, reflect, and create, she said. The most effective way to keep me on that track and not get too slumped down is by journaling.

If people decide to take up the hobby, families can read their relatives accounts of what life was like for generations to come, which can be a profoundly moving experience, Cain said. By keeping it physical rather than virtual, the authors can rest easy knowing their memories wont be lost because of a forgotten password, and, in Cohens experience, an obsolete floppy disk.

[Journals] remind us of our common humanity across time and space, and that's something that we will always need as human beings, Cain said. As historians and scholars certainly, but as citizens and people, it's really important to have a glimpse of the human mind and the human heart. Diaries give us this.

Matt Berg can be reached at matthew.berg@globe.com. Follow him on Twitter @mattberg33.

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Journaling during the pandemic, for yourself and the historians - The Boston Globe

COVID-19: Lockdown envelopes film and entertainment sphere – United News of Bangladesh

The ongoing COVID-19, recently announced by WHO as a global pandemic around the whole world, has been causing a global shutdown in several sectors including media and entertainment even the most famous event on the annual film festival calendar, at Cannes, has been postponed. The entertainment and film industry of Bangladesh is no different.

All activities of Bangladesh Film Development Corporation (FDC) have been paused due to the virus fear, although a rally was held from FDC on Saturday by the Bangladesh Film Artistes Association and attended by its president Misha Saudagar, General Secretary Zayed Khan, actor Dipjol, Ilias Kanchan and more. They distributed masks and requested fans to be aware and avoid panicking about the Coronavirus.

Amid the fear of the COVID-19, the government in Bangladesh has recently shut down many institutional activities after the confirmation of local transmission and death cases of coronavirus cases to prevent the virus from spreading, and cinema halls all over the country are currently going into lockdown mode from March 18 to April 2 due to the pandemic, according to Bangladesh Film Producers-Distributors Association President Khorshed Alam Khosru.

While asked about the ongoing crisis and possibilities of a nationwide shutting down of the cinema halls, Khosru told UNB that the association has decided to close all the halls until April 2.

As the virus passes from human to human in close proximity, people inside crowded arena such as cinema halls are at a higher risk to be contaminated with the virus - so we decided not to continue the shows in any of the halls including the cineplexes from March 18 to April 2, Khosru told UNB.

If the crisis continues, the longevity of the decision can get extended until the situation gets normal he further added.

However, countrys top cinema multiplexes including Blockbuster Cinemas at Jamuna Future Park and all branches of Star Cineplex (Bashundhara City, Shimanto Shambhar and SKS Tower) have postponed their activities since March 20; two days after the declaration came out from the association and health authorities.

Regarding the movies being showcased prior to the ban, Shakib Khans movie Shahenshah was the only one significant release that came out on March 6, and was running at over hundred halls before the closing.

As of now, movie lovers and hall owners are counting days for Shakibs upcoming movie Bidrohi and Nabab LLB, Arifin Shuvoo starring action extravaganza Mission Extreme, Siam Ahmed starring action film SHAAN, Ananta Jalils Bangladesh-Iran joint venture Deen - The Day, Tollywood star Dev starring Bangladeshi spy thriller film Commando, to name a few for the Eid-Ul-Fitr releases which they expect to make up for the loss in the meantime, due to the Coronavirus only if the uncertain situation get normal within the time.

Actors and actresses at home and abroad had already taken necessary steps to warn their admirers about the virus, either with the news about their own isolation or promoting safety measures via social media. Dhallywood stars including Shakib Khan, Siam Ahmed, Arifin Shuvoo, Riaz Ahamed and Bollywoods megastars including Salman Khan, Shahrukh Khan, Hrithik Roshan and more have either posted video messages or status posts, requesting fans to be aware and safe from COVID-19.

At the same time several production houses, actors, directors and producers in Bangladesh and India have opened joint fundraising platforms online, for the production crews who might suffer devastating financial loss due to the lockdown.

Coming back to the theatre sphere of Bangladesh, all activities including shows, rehearsals and others have been suspended by the Bangladesh Group Theatre Federation from March 17 to 31 to prevent the spread of coronavirus. Besides, Bangladesh Shilpakala Academy (BSA) has also suspended activities on all of their theatres and auditoriums till March 31.

On last Thursday, representatives of Actors Equity, Directors Guild, Television Programme Producers Association of Bangladesh and others met information minister Hasan Mahmud, discussed the circumstances and decided to postponed shootings of small screen productions including Television commercials (TVC), drama serials and others from March 22 to 31.

Every one involved in the entertainment and media sphere at home and abroad are eagerly waiting to see the damage of COVID-19 minimised and for the world to come out of the grip of the pandemic.

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No, not everything about mens sexual behaviour can be explained by testosterone – Scroll.in

We place unreasonable trust in biological explanations of male behaviour. Nowhere is this truer than with testosterone. Contemporary pundits invoke the hormone nicknamed T to prove points about maleness and masculinity, to show how different men and women are, and to explain why some men presumably those with more T have greater libidos. Yet, despite the mythic properties popularly associated with T, in every rigorous scientific study to date there is no significant correlation in healthy men between levels of T and sexual desire.

Beginning in the 1990s and really picking up steam in the 2000s, sales of testosterone replacement therapies went from practically zero to over $5 billion annually in 2018. This was either because there was a sudden outbreak of Low T when a major medical epidemic was finally recognised, or because T became marketed as a wonder drug for men thrown into a panic when they learned that their T levels declined 1% annually after they hit 30.

The answer is not that mens bodies changed or that Low T was horribly underdiagnosed before but that, in the minds of many, T became nothing short of a magic male molecule that could cure men of declining energy and sexual desire as they aged.

Whats more, many have been taught that, if you want to know what causes some men to be aggressive, you just test their T levels, right? Actually, wrong: the science doesnt support this conclusion either. Some of the famous early studies linking T and aggression were conducted on prison populations and were used effectively to prove that higher levels of T were found in some men read: darker-skinned men which explained why they were more violent, which explained why they had to be imprisoned in disproportionate numbers. The methodological flaws in these studies took decades to unravel, and new rigorous research showing little relation between T and aggression, except at very high or very low levels, is just now reaching the general public.

Whats more, it turns out that T is not just one thing a sex hormone with one purpose male reproduction. T is also essential in the development of embryos, muscles, female as well as male brains, and red blood cells. Depending on a range of biological, environmental and social factors, its influence is varied or negligible.

Robert Sapolsky, a neuroscientist at Stanford University in California, compiled a table showing that there were only 24 scientific articles on T and aggression 1970-80, but there were more than 1,000 in the decade of the 2010s. New discoveries about aggression and T? No, actually, although there were new findings in this period showing the importance of T in promoting ovulation. There is also a difference between correlation and cause. T levels and aggression, for example, provide a classic chicken-egg challenge. As leading experts on hormones have shown us for years, for the vast majority of men, its impossible to predict who will be aggressive based on their T level, just as if you find an aggressive man or woman, for that matter you cant predict their T level.

Testosterone is a molecule that was mislabelled almost 100 years ago as a sex hormone, because scientists were looking for definitive biological differences between men and women, and T was supposed to unlock the mysteries of innate masculinity. T is important for mens brains, biceps and that other word for testicles, and it is essential to female bodies. And, for the record, (T level) size doesnt necessarily mean anything: sometimes, the mere presence of T is more important than the quantity of the hormone. Sort of like starting a car, you just need fuel, whether its two gallons or 200. T doesnt always create differences between men and women, or between men. To top it all off, there is even evidence that men who report changes after taking T supplements are just as likely reporting placebo effects as anything else.

Still, we continue to imbue T with supernatural powers. In 2018, a United States Supreme Court seat hung in the balance. The issues at the confirmation hearings came to focus on male sexual violence against women. Thorough description and analysis were needed. Writers pro and con casually dropped in the T-word to describe, denounce or defend the past behaviour of Justice Brett Kavanaugh. One commentator in Forbes wrote about testosterone-induced gang rapes. Another interviewed on CNN asked, But were talking about a 17-year-old boy in high school with testosterone running high. Tell me, what boy hasnt done this in high school? Yet another column in The New York Times read, Thats him riding a wave of testosterone and booze

And it is unlikely that many readers questioned the hormonal logic of Christine Lagarde, then chair of the International Monetary Fund, when she asserted that the economic collapse in 2008 was due in part to too many males in charge of the financial sector: I honestly think that there should never be too much testosterone in one room.

You can find T employed as a biomarker to explain, and sometimes excuse, male behaviour in articles and speeches every day. Poetic licence, one might say. Just a punchy way to talk about leaving males in charge. Yet when we raise T as significant in any way to explain male behaviour, we can inadvertently excuse male behaviour as somehow beyond the ability of actual men to control. Casual appeals to biological masculinity imply that patriarchal relationships are rooted in nature.

When we normalise the idea that T runs through all high-school boys, and that this explains why rape occurs, we have crossed from euphemism to offering men impunity to sexually assault women by offering them the defence not guilty, by reason of hormones.

Invoking mens biology to explain their behaviour too often ends up absolving their actions. When we bandy about terms such as T or Y chromosomes, it helps to spread the idea that men are controlled by their bodies. Thinking that hormones and genes can explain why boys will be boys lets men off the hook for all manner of sins. If you believe that T says something meaningful about how men act and think, youre fooling yourself. Men behave the way they do because culture allows it, not because biology requires it.

No one could seriously argue that biology is solely responsible for determining what it means to be a man. But words such as testosterone and Y chromosomes slip into our descriptions of mens activities, as if they explain more than they actually do. T doesnt govern mens aggression and sexuality. And its a shame we dont hear as much about the research showing that higher levels of T in men just as easily correlate with generosity as with aggression. But generosity is less a stereotypically male virtue, and this would spoil the story about mens inherent aggressiveness, especially manly mens aggressiveness. And this has a profound impact on what men and women think about mens natural inclinations.

We need to keep talking about toxic masculinity and the patriarchy. Theyre real and theyre pernicious. And we also need new ways of talking about men, maleness and masculinity that get us out of the trap of thinking that mens biology is their destiny. As it turns out, when we sift through the placebo effects and biobabble, T is not a magic male molecule at all but rather as the researchers Rebecca Jordan-Young and Katrina Karkazis argue in their book Testosterone a social molecule.

Regardless of what you call it, testosterone is too often used as an excuse for letting men off the hook and justifying male privilege.

This article first appeared on Aeon.

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No, not everything about mens sexual behaviour can be explained by testosterone - Scroll.in

Coronavirus: 14-hour Janta curfew will not break the cycle of infection – Deccan Herald

On March 19, Prime Minister Narendra Modi gave a29-minute addressto take precautionary measures including observing a Janta Curfew on March 22 from 7 AM to 9 PM to prevent the spread of the coronavirus in India.

Since then, several social media users have posted a text claiming that the coronavirus has a life cycle of 12 hours and a 14-hour curfew will help to break the chain and curb the further spread of the virus. This text is viral inEnglish,Hindi,andTelugualong with the hashtag #JantaCurfew.

The viral message has been shared onTwitter,Facebookand WhatsApp.

False:

Also Read:What can you do to kill time during 'Janta Curfew'?

FACT-CHECK

A viral infection can be transmitted from one individual to another in multiple ways.

1) Direct: From one individual to another individual either via means of touch, or if the infected individual coughs or sneezes in close vicinity of another person.2) Indirect: When an infected individual touches a surface, and another individual touches the same surface.

In the course of this article, we will demonstrate that a 14-hour self-imposed curfew will not break the cycle of infection as the coronavirus persists 2-3 days later on surfaces. However, social lockdown is an effective strategy for reducing new infections that flattens the curve.

Also Read:Janta Curfew: Stay at home call may deepen slowdown in Indian economy

Infected individual can pass the infection for upto two weeks

The novel CoV infection has a high incubation rate. The scientists at Imperial College, UKestimatethat each coronavirus patient infects on average 2.6 others, making it almost as infectious as yearly influenza outbreaks. While the common influenza virus has a short incubation period and is self-resolving, the 2019-nCoV can be incubated for up to two weeks, hence increasing its chances to infect other people. So, someone who is infected with CoV would be able to pass it on to someone else till upto two weeks, even if the former isnt yet displaying any symptoms.

Coronavirus can be detected on surface for upto 3 days

Alt News Science recently published anelaborate fact-checkregarding how long can coronavirus live on various surfaces. Research(Doremalen et al 2020)published in the New England Journal of Medicine conducted by American scientists (preprint here) suggests that the new coronavirus (COVID-19) can live in the air for several hours and on some surfaces for as long as 2-3 days. They tested the virus by spraying into the air by a nebuliser mimicking the coughing action of an infected person. They found that it could be detected up to a minimum of 3 hours later in the air, up to 4 hours on copper surfaces, up to 24 hours on cardboard and up to 2-3 days on plastic and stainless steel surfaces.

The longevity of the virus was determined by studying the decay time or half-life of the virus, which is the time it takes for it to reduce in 50% tissue-culture infectious dose (TCID50) per litre of air. It was determined that the virus stayed on cardboard, stainless steel and plastic for the longest period, in comparison to copper and aerosol droplets.

On average, the half-life of the virus on plastic surface was the highest, with an average of 15.9 hours (high 19.2 hours), copper was lower 3.4 hours (high 5.11 hours), and stainless steel was 13.1 hours (high 16.1 hours). No research was conducted on fabric at all.

For latest updates on coronavirus outbreak, click here

The study also suggests that the virus can spread through the air, from touching things that were contaminated by those who are infected, and through direct human contact. The virus was formerly known as HCoV-19, but is referred to as SARS-CoV2 in this study as the comparison of longevity was in comparison with the virus found in the previous coronavirus outbreaks, known as SARS-CoV or SARS-CoV1 in the study quoted above.

Thus, an individual infected with coronavirus can pass on the infection to another person for upto 14 days. Also, the coronavirus could be detected up to 2-3 days on plastic and stainless steel surfaces. The results from this study indicate that the coronavirus can be transmitted through aerosols (clusters of the virus in the air) aerosol and fomites (objects such as plastic, steel, other metals contaminated with the virus) are plausible, as the virus can remain viable in aerosols for multiple hours and on surfaces up to days. Hence, a 14 hour self-imposed curfew cannot break the cycle of infection as it is being claimed on social media. Despite the fact that the curfew will not break the cycle of infection as the Coronavirus still persists 2-3 days later on surfaces, the social lockdown is an effective strategy for reducing new infections that flattens the curve

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Coronavirus: 14-hour Janta curfew will not break the cycle of infection - Deccan Herald

COLUMN: Living history, and pondering books to be written – Baker City Herald

As we live through historic events that arrive not every day but every hour, Im thinking of the future as well as the present.

It is ever fascinating to me to wonder what I might remember, years and decades from now, about changes which in their immediacy and sheer volume seem so monumental that their vibrancy cant be tarnished by time.

Sept. 11, 2001, for instance, was a milestone one of a handful of epochal days in American history and probably the most notable in my lifetime (I was born in 1970).

Yet my recollections of that sunny September day lack the clarity I would have predicted, even at the span of nearly two decades.

I think the coronavirus might well be different dramatically so.

Indeed I think its plausible to believe that for Americans old enough to form lasting memories of these days in the winter and spring of 2020, the coronavirus crisis will attain a prominence not so dissimilar to that of World War II among the generations that lived through that conflict.

I dont mean to suggest the two events are comparable on certain levels, to be sure.

America was directly involved in the Second World War for close to four years, and nearly half a million service members died.

There is good reason to believe that coronavirus in our country will not approach the wars longevity or death toll.

But no single event since that war has caused such upheaval to our society, at the most fundamental levels, as coronavirus has done.

The repercussions arrived so rapidly that Ive felt a trifle overwhelmed, as though I were caught in one of those terrible dreams in which the tasks accumulate but I seem helpless to deal with even one.

(And like as not, while clad only in my underwear.)

In the span of a few days, all manner of traditions that seemed as reliable as the passage of the seasons became casualties.

Sports all but ended.

March Madness, a symbol of spring as certain as the chilly north wind buffeting Baker Valley (but much less annoying), was canceled.

Schools closed.

Sit-down meals at restaurants are banned, and theaters dark and silent.

Terms such as social distancing have entered the vernacular, and I suspect they will be more difficult to dislodge than the slogans of past crises gas lines, for instance.

It is natural, and reasonable, to compare these precautions, some of them unprecedented in our lifetimes, with the level of the threat and decide for ourselves whether we think the scales are balanced.

I understand why some people say they are not indeed, that the response is grossly exaggerated.

Doctors agree that the coronavirus, though quite infectious, has a relatively low fatality rate of roughly 2% and much lower yet for young, otherwise healthy people.

I suspect many people, including those who dismiss the more dramatic precautions as hysteria, assumed if they ever thought about the subject that only a disease that was both easily spread and widely fatal would prompt this level of response.

There is, Ill concede, a certain comfort in the statistics. The same is true for our individual risks of, say, dying in a car crash. Most of us, after all, probably will not contract coronavirus. And most of those who do will survive, quite likely without even knowing the virus breached our defenses.

Yet despite this relatively remote risk of any one of us suffering severe illness, much less dying, I dont believe Americas response to coronavirus is unreasonable.

This is partly because of the uncertainty.

We know much more about how dangerous coronavirus is now than we did even a few weeks ago. But I am not comfortable making broad assumptions about a virus that, until around the turn of the year, few people who dont work in virology likely had heard of.

Moreover, the restrictions we have either taken voluntarily, or that have been imposed by the government, are indisputably effective at reducing the spread of the disease.

And although the short-term effects can be serious most notably the economic harm absent these precautions the coronavirus would infect far more people, and the blow to business likely would be even more persistent and dire.

None of this, obviously, can be proved now.

Which returns me to my original point about pondering the future.

It seems to me that budding sociologists and other observers of human society will have plenty of topics to keep them academically occupied for years, if not decades.

By 2040 bookshelves will sag, I suspect, with the work of historians who have examined every aspect of the great coronavirus crisis of 2020 (ideally, of course, it will be confined to a single year).

I like to think Ill pass enjoyable hours in my dotage reading some of these.

But I wonder how much Ill remember of what it was really like. How vividly will I be able to recall when the closures were arriving in my inbox with stunning rapidity, when toilet paper jokes were the epitome of humor, and when the issue of airborne droplets was suddenly, shockingly, more important than the Final Four.

Jayson Jacoby is editor of the Baker City Herald.

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COLUMN: Living history, and pondering books to be written - Baker City Herald

Five Factors Influencing The Mobility Solutions Industry – Forbes

Mobility and accessibility solutions are products and services that meet the needs of a dynamic spectrum of people with varying degrees and types of disabilities that result in mobility and accessibility challenges.

Products you could offer in this industry include stairlifts, ramps, scooter carriers, mobility scooters, elevators, vertical platform lifts and more, as well as the services provided by installers, dealers and distributors.

While it may not be what most would consider a sexy industry, I expect this market segment to expand even more rapidly as the United States sees a shift in demographics and demand increases.

Lets explore some of the key factors influencing the mobility solutions industry and how to determine if it's the right industry for you.

1. There are more older people.

According to the U.S. Census Bureaus 2017 National Population Projections, all baby boomers will be older than 65 by 2030. For the first time in history, older people are projected to outnumber minors by 2034, and experts predict that 77 million people will be over the age of 65 in the United States by 2034.

I have already seen the positive impact this shift has had on the mobility and accessibility solutions industry, and I expect it will only increase as the aging population continues to grow.

2. More of these Americans are choosing to age in place.

Not only will the coming years see greater numbers of older Americans, but a growing trend is also making the mobility solutions industry even more appealing.

Instead of selling the homes where their families grew up to move to retirement communities or assisted living facilities, more older people are deciding instead to age in place. According to a 2014 AARP survey (viaHomeCare), 87% of those over 65 want to age in place.

An entire realm of education and advice about this has developed, on which entrepreneurs can capitalize. For example, the National Institute on Aging offers material on costs, concerns and issues related to aging in place.

3. You can offer a variety of modifications.

Whether an older person wants to age in place in their own home or move into the home of a child or relative, there are often many areas in a home that companies can modify for them. Similarly, when a child or spouse becomes disabled, you can offer them adaptations.

According to a recently updated article on AgingInPlace.org, the 2015 American Housing Survey conducted by the U.S. Census Bureau looked at 118,290 homes, only 36,845 of which were one-story homes; 66,534 reported that steps were necessary to access their homes from the outside. But even flat floors and narrow doorways can make life tough.

4. Service is a necessary, ongoing human component.

The equipment and products themselves are just some of the solutions you can offer. The people for whom these products are designed need help. Consider providing installation services as a vital part of a comprehensive solution that provides the help they need.

Consider the example of a wheelchair-bound customer who lives in a house with four steps at the front door. This affects the life of the disabled resident as well as friends, families and caregivers who must be present to lift the wheelchair up and down the steps.

As a mobility solutions provider, you should be able to dispatch an installer promptly to efficiently install a lift or ramp to become a trusted go-to in the area.

Success and longevity in this industry will also require you to provide ongoing service and support, including routine maintenance beyond the sale and installation.

5. Positive energy can fuel your momentum.

Another factor that can quietly drive your success in this industry is the spirit of the people behind your business. The connections built between business owners and their customers and the satisfaction that comes with helping others in need are big parts of why many who get into this business love it.

At first blush, an outsider might think of the mobility and accessibility solutions business as profiting from the misfortunes or problems of others. The reality, however, is quite the contrary. The need exists, regardless of how unfortunate, and someone has to provide the necessary solutions. When you build a business that addresses the needs of a growing population, everyone can benefit.

Those of us with full mobility often take for granted the simplest things in life. Being able to make a night-and-day difference in a customers quality of life is incredibly rewarding and can make business ownership in this segment an attractive opportunity.

If you are considering pursuing a business opportunity in this growing industry, you might ask yourself a couple of questions to decide if it's the right fit for you. Do you have an outgoing and engaging personality? Will you enjoy assisting aging, disabled and special needs customers with ways their homes and the businesses they visit can be modified and/or better equipped? Are you outgoing, and do you enjoy relationship development activities with other business owners and agencies? Are you a strong team leader who can build and lead a motivated team of employees with the same vision that you have?

If so, here are a few things to look into:

Do some local market research to find out how many businesses are involved in this. Don't be worried if you find some, because odds are you will. In fact, I'd be more concerned if you didn't. It's always important to know who and where the competition is.

Once you've found the competition, secret shop a few of them. This will allow you to see what you might be doing on similar appointments in the future. Is it something that you feel as though you'll enjoy? You can also see where you might handle things differently or differentiate yourself.

Do some local research to find senior and/or disabled persons support agencies. Go visit an agency director, and find out what kind of activities and events they sponsor. See if they have something that you could do or be involved with.

Did you enjoy this process, and can you see yourself engaged in these kinds of activities as a norm?

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Five Factors Influencing The Mobility Solutions Industry - Forbes

Are CEOs displacing CHROs in the workplace transformation? – HR Dive

Dive Brief:

While technology may be the most obvious herald of a workplace transformation, culture and upskilling still concern experts and execs in the space. In late 2019, Glassdoor said 2020 would mark the start of a "culture-first decade"in recruiting, particularly regarding diversity and inclusion. However, a study released in early March 2020 by Accenture found that culture is not a top strategic priority for company leaders; instead, financial performance and brand recognition took the top spots.

"Given that this is primarily a people initiative," the Infosys study said, "we hope to see more CHRO involvement in the near future."

The Glassdoor study did say technology particularly the adoption of mobile devices would be a major concern for companies in the new decade. Employee experience with technology may be a pain point; in an index created and released by Nexthink, large companies scored lowest on four of the five categories measured. Categories included collaboration platforms, productivity tools, workplace devices and business services and applications. Employers have good reason to focus on employee experience with tech, according to various studies. Those that focus on the human experience tend to have better employee performance across the board, Deloitte said in a study released in August 2019.

While left behind in the Infosys study, upskilling may be a prime concern for the longevity of a workplace transformation, a January Randstad studynoted, especially because the talent shortage remains a top worry for CEOs. While a majority of HR respondents (91%) said they believe it's their organization's responsibility to reskill workers, only 22% are training or reskilling their workforce to address shortages or digital transformation.

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Are CEOs displacing CHROs in the workplace transformation? - HR Dive

Philippe Starck Is Living the Future – Mansion Global

Its difficult to describe Philippe Starck in a few wordsor even a few sentences. The French designer, whos known globally for his work in interior, exterior, product, furniture, industrial, and architectural design, has designed everything from low-energy wooden prefabricated houses (known as P.A.T.H., or Prefabricated Accessible Technological Homes), to yachts and hotels, to the residences of the French president.

Hes also responsible for one of the worlds most iconic pieces of furniturethe ghost chair.

Mr. Starck, 71, has coined the phrase democratic design, describing it as something that provides quality pieces at accessible prices.

More: Aspen Brokerage Founder Says Its Core Area is Expanding

And early this year, he announced his newest furniture collection, Oh, It Rains!, in collaboration with B&B Italia Outdoor, a company that focuses on functional furniture. The sofas and armchairs in the collection include a mechanical joint that allows the backrest to recline, as well as to fold over the cushions in order to protect the furniture in case of rain. The pieces are made of water-repellant proprietary textiles.

Outside of furniture and home design, Mr. Starck also had a brief stint as art director for the Virgin Galactic spaceport, is a winemaker (with his own Champagne with Maison Louis Roederer), makes perfume under the label STARCK Paris (interestingly, his mother operated a parfumerie when he was a child), and creates ultraflexible eyeglasses in collaboration with Luxottica, a project that combines design with biomechanics.

We caught up with Mr. Starck to discuss his passions, his inspirations, and what he felt was missing from outdoor furniture.

From Penta: Worldwise: Chef Nina Comptons Favorite Things

Mansion Global: Who are some of your inspirations in the design world?

Philippe Starck: I have no admiration for designers, architects, or artists. I love scientists. My heroes are Ptolemy, Einstein, Archimedes, et cetera. They are among the ones who change the world.

What does democratic design mean to you now? Has that changed throughout the years?

Im not really proud of what I do because design is useless. It can help improve lives, but it does not save lives. However, Im proud of my battle to democratize design: increasing quality, yet lowering prices in order to make design affordable for the wider public. Now that this battle is won, I can continue with democratic ecology and democratic architecture. I started with P.A.T.H., highly technological and high-quality prefabricated houses, to save energy, time, money, and guarantee longevity at the right price. Recently, I worked on the next commercial International Space Station in collaboration with Axiom to develop commercial space tourism. Im very happy to take part in this project because companies like Axiom are focusing on space research and are searching for solutions in order to democratize space.

How did the project with B&B Italia come about? What was your design inspiration for that collaboration?

I always say that to make beautiful children, parents have to be in love. Its the same with projects; to make beautiful projects, you have to share the same values with your partner. I always thought there was something wrong with outdoor furniture collections. When you are in a beautiful hotel, enjoying the swimming pool, and suddenly someone says: Oh, it rains! and hundreds of waiters start panicking, picking up all the pillows and cushions, there is something not quite right. So I wanted to create a solution. I worked on a whole range of options that allow you to intervene in a few simple steps when it starts to rain. For example, by simply folding the backrest forward, you can cover the upholstery like a protective flap, and as soon as the sun comes back, simply unfold and youre ready. This is the most elegant design made with high technology, high quality, and high intelligence.

More: Barrier-Breaking Architect Says Its Time for More Women in the Field

What will the furniture of the future look like?

Design is a simple tool that has been created to improve the ugly obligations of our daily life. There is no future for design, as we are now entering the era of bionism [the art of taking inspiration from the body to create technologies better suited to the human being, according to Mr. Starck] and dematerialization. In the coming years, all the useless things around us will disappear, they will become integrated directly into the walls, to the body. The next designer will be our coach, our dietician.

Youve also launched perfume. How do you get inspired to come up with scents? And what interests you about being in that business?

STARCK Paris is not a design project. It is a personal project, coming from my brain, from my heart. ...With my wife, Jasmine, we spent years discovering the works of almost all existing master perfumers,

carrying out blind tests. And eventually we recognized Daphn Bugey, Annick Mnardo, and Dominique Ropion as part of my sentimental tribe. People who share a vision and creative intelligence. We invented a new diagonal language in order to translate my vision, my mental space, actually turning my words into chemicals and perfumes. I am passionate about perfume because it is so powerful, abstractlike a vehicle, a weapon. With a nanodrop of scent, that is less than a milligram of liquid, you can create your own universe, your own territory.

Whats next for you?

To continue to direct my creation and my production toward immateriality, toward the minimum while giving the maximum. My Starck Biotech Paris glasses are a good example. We continue to explore biotechnology, while working on dematerialization and bionism by proposing new, innovative solutions. ... stay tuned.

This story first appearedin Mansion Global magazine, published on March 14th, 2020.

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Philippe Starck Is Living the Future - Mansion Global

Stephen Colton’s Take on Nature: Ancient harts-tongue fern catches the eye – The Irish News

I'VE been thinking lately how much we take our senses for granted, those windows to the world, and how the treadmill of living dulls our appreciation of experiences they give us.

Most days I walk familiar routes, passing similar landmarks; a bend in the river, a particular tree, banks or hedgerows. Such repetition brings complacency when looking at certain things along well-trodden paths.

A fern whose lineage, according to fossil records, stretches back to around 360 million years ago is a plant I've given a frequent glance, but have neglected to properly acknowledge.

It took the presence of a grey wagtail, dancing and bobbing nearby recently, to prompt my first serious consideration of the native Hart's-tongue, as it hung in clusters from the damp rocky crevices of the riverbank, its undivided fronds, glossy green and shiny.

The tongue-shaped pointed leaves along with hart', the name for an older male red deer, give rise to its name, resembling a deer's tongue' or teanga fia' in Irish.

Some other names have been noted for the fern such as cow tongue' (Hart, 1898) and fox's tongue' (Colgan 1904).

The sporangia which produce and contain the spores are arranged in lines along the underside of the leaves resembling a centipede's legs, hence the species name 'scolopendrium', Latin for centipede. Ferns reproduce by releasing these spores and have neither seeds nor flowers.

Though battered by recent storms and fluctuating water levels, the arching leaves of these ferns will soon be replaced by new luxuriant blades unfurling in late spring.

Hart's-tongue, which prefers woodlands, hedgerows and damp shady places, is just one of the many fern varieties found in Ireland. Their graceful feathery fronds have fascinated poets and writers for centuries. In his poem The Stolen Child (1886) WB Yeats, reaching for the innocence of childhood again, writes of the lure by the fairies:

"Leaning softly out?From ferns that drop their tears?Over the young streams" to

"Come away, O human child!?To the waters and the wild'".

Another giant of the Romantic poets, Coleridge in an early version of the poem This Lime-Tree Bower my Prison (1797), writes of "the ferny rock/Whose plumy ferns forever nod and drip". He later wrote in one of his notebooks, "An eminently beautiful object is Fern".

In the Irish legend of Mad Sweeney, the outcast King castigates fern, saying "There is no bed for an outlaw/In the branches of thy crests".

Like many plants with such longevity, hart's tongue has been used for medicinal purposes by past communities to treat coughs, digestive problems and open wounds.

Culpeper's Complete Herbal (1653), still in print today, said of the plant, "Hart's Tongue is much commended against the hardness and stoppings of the spleen and liver, and against the heat of the liver and stomach, and against the bloody-flux. Dioscorides [a Greek physician] saith, it is good against stinging or biting of serpents."

A record from Co Limerick in a manuscript of the Irish Folklore Commission tells how hart's-tongue leaf was burned and applied to cure burns. It is also thought that fern was used to brew ale in early Ireland. In the Lebor Gabla, or Book of Invasions, Malaliach is said to have been the first brewer in Ireland making lind ratha or fern ale'.

The male grey wagtail showed off its black throat and bright yellow underside as it moved along the river bank in search of food, before flying off downstream, in undulating pattern low above the water and out of sight, its job of drawing me towards the fern, now done. Keep well.

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Stephen Colton's Take on Nature: Ancient harts-tongue fern catches the eye - The Irish News

Dr. Ronnie S. Stangler: What Does Madonna Know About Her Genes That You Don’t? Genomics and Its Impact on Families of Wealth | Horizons: Family Office…

Ronnie S. Stangler, M.D., physician and psychiatrist, is Founder of Genome Advisory, based in New York City. Uniquely positioned at the intersection of health, wealth and science, Genome Advisory consults with individuals, global families and their advisors, using the DNA science of genomics to enhance strategic plans regarding health, risk and legacy.

Dr. Stangler served for over a decade as Chief Medical Officer to an international family office in London, Liechtenstein and Switzerland.

She is Clinical Professor of the Department of Psychiatry and Behavioral Sciences at the University of Washington, and contributed as Advisor to the Department of Genetics, Personal Genetics Education Project, Harvard Medical School.

When Madonna performs, she reportedly engages a sterilization team to sweep, mop and wipe every surface of her dressing room, so that no trace of her DNA is left for surreptitious analysis, cloning or experimentation. Hacking portends the specter of a black market which will trade in valuable genetic information about prominent individuals and families. Is Madonna paranoid? Or smart? You decide...

2020: THE AGE OF THE GENOME

The DNA science of genomics is now a critical part of strategic planning regarding health, risk and legacy for wealthy individuals, global families and their advisors.

Every living organism is made up of cells. Each cell contains a set of genes encoded with DNA which provides comprehensive instructions that constitute the master blueprint for our lives. In conjunction with environment and lifestyle, our genes are responsible for determining fundamentals of who we are: our appearance; traits; how we survive and prosper; how we age; how we decline.

Genes are our universal inheritance and legacy. They have been so since the onset of humankind. Historically they have been an invisible presence. Until now.

We have entered the Age of the Genome, an extraordinary era of transformative biotechnology. Today, we can not only fully see our genes - an essential building block of our humanity - but we can read them like the words of a book. And now we can edit, enhance and create genes, as well.

GENETICS vs GENOMICS

Genetics is the study of heredity and individual genes. Many of us first learned about genetics in high-school biology as we contemplated Mendels pea plant experiments of the 1860s.

Genomics is the study of an organisms complete set of genes, called the genome, the entirety of its DNA. The genome can be analyzed through a process called whole genome sequencing (WGS).

The first human genome was sequenced in 2003. This fifteen year project cost over $3B. Today, we can analyze the human genome for less than $1,000 within weeks. Personal motivations for WGS currently include: accessing health information, often providing actionable insights; understanding disease risk; knowing what one will pass on to ones children; and receiving information about response to particular medications (pharmacogenomics).

GENOTYPING vs WHOLE GENOME SEQUENCING

While DNA and genes are now very much a part of public consciousness, propelled mostly by widespread adoption of direct-to-consumer (DTC) genotyping products (e.g. 23andMe, Ancestry.com, etc.), few understand the specifics of what these products offer.

The technology underlying direct-to-consumer genetic analyses is genotyping, which provides a limited picture of less than one percent of ones genes, preselected by individual companies on the basis of known associations with specific traits and diseases.

Alternatively, whole genome sequencing provides a literal snapshot of the entirety of ones genes. Some have compared the difference between genotyping and WGS to the difference between a tricycle and a race car.

GENOMICS AND WEALTH

The wealthy represent a population with the same concerns about health and genes as all others. However, factors in their environment generate unique concerns. The very terms family enterprise, family office and family legacy convey their requisite focus on all that is family. And genes permeate all aspects of family.

Traditionally the wealthy have focused on financial well-being, preservation and growth of capital. New knowledge of family genes will progressively influence all aspects of health, physical and emotional well-being; reproduction and family relationships; as well as the most traditional domains of family advising and operation of family enterprise. And the wealthy are already amongst the earliest adopters of cutting-edge DNA science.

Genomic information is already being used to inform best decisions around health, risk and legacy. Thus, knowledge of genomics and its impact on wealthy families is now part of an essential toolkit for the family advisory. Preeminent families have already embraced planning of genomics strategy.

VIEWING THE FAMILY OFFICE THROUGH THE LENS OF GENOMICS

Genomics has moved from an abstract quantitative entry in investment portfolios to a vital living tool for creating healthier, longer, disease-free lives.

How can we consider succession without considering genes??Heredity is succession. It is the succession of genes. How will succession planning be affected by knowledge of health futures of family members?

How can we consider trusts without considering genes??As we learn more about health risks, there are profound financial and social implications. If a family member has significant likelihood of imminent disease, appropriate planning is critical. What family resources should be allocated to access new mitigating interventions? Early gene- editing therapies are extremely costly, and no matter how wealthy a family, resources are finite.

How can we consider estate planning without considering genes??Radical longevity and the genetic means to achieve it will alter financial requirements. New financial instruments must be developed to accommodate increased lifespan.

How can we consider fiduciary responsibility without considering genes??Trustees and advisors will be challenged by new medical information that is difficult to interpret. Deciding how to utilize this information creates unprecedented ethical dilemmas. Families must align on an ethical framework to guide such decisions.

How can we consider governance without considering genes??Governance must reflect a common family vision with the understanding that genetics is not a solo sport. Every biologically related family member is literally tied to every other by the life thread of shared DNA.

How can we consider next-gen without considering genes??Next-gen have access to rapidly evolving radical reproductive technologies. They must also navigate new relationships with parents who may be physically and mentally vital well into their nineties and beyond. Parents may wish to continue their tenure within the family enterprise. This will create new frictions. Parents may also choose to create genetically enhanced new children, perhaps younger by an entire generation than their older siblings.

DEVELOPING A GENOMICS STRATEGY FOR YOUR FAMILY AND FAMILY OFFICE

Family offices are as unique as the families they serve. Genomics strategy must be developed to support families as they navigate the complex field of genomics and engage with the science directly.

Human and behavioral perspectives cannot be ignored. Genomic information will have an impact on family dynamics; family identity; and the psyches of individuals who learn about new health risks, vulnerabilities and opportunities for enhancement.

Wealthy families are already formalizing family genomics chartersto guide ethical decision making, now and through the future.

Genes are rarely absolute destiny. Our environment and life experiences profoundly alter the expression of genes. Will knowledge of genes spur us to better life choices? Change is challenging. Family members require high-touch support to alter behavior in positive ways.

There is dire need, as well, for trustees and advisors to understand the complex nature of systems of wealth and to integrate rapidly evolving biological considerations through processes when appropriate and beneficial to do so. Trustees and advisors will help determine how decisions are made; where sensitive data is saved; who has the right to access such data and when; and how resources will be allocated.

Families of wealth have the financial means to direct education and funding of medical initiatives of unique concern, as well as the potential to fund more generative, legacy and aspirational projects.

For example, when Sergei Brin, Co-Founder of Google, learned about his genetic vulnerability to Parkinsons Disease, he radically altered his philanthropic strategy to support basic science research in the field. After changing the way the world searches for information on the web, he has now revolutionized how scientists approach Parkinsons Disease.

Genomics will inevitably become an essential component of the family philanthropy portfolio in highly personal ways.

RISK MITIGATION FOR UHNW FAMILIES

Risk mitigation is a core responsibility in management of UHNW families and wealth. Direct- to-consumer genetic testing products present risks that must be contained immediately.

In December 2019, the United States Pentagon provided strong caution about the use of consumer genetic products by the military (Pentagon Warns Military Personnel Against At-Home DNA Tests, The New York Times, 24 December 2019).

Legal professionals have spoken out as well: Collecting [genetic] data could have unintended consequences. It can be lost to hackers, spies, others who might steal it... or exposed in government investigations through subpoenas... So people planning to plaster their deepest internal and family secrets into private company databases should consider the risks that the private DNA mills dont want you to think about. (The Shell Game Played with Your DNA, or 23 and Screwing Me, The National Law Review, 23 January 2020).

These groups represent a mere handful of increasingly concerned entities who detail gross compromise of privacy, security and accuracy. And Madonna saw it coming!

As a predominantly unregulated industry, DTC genetic testing entities often provide misleading information based on pseudoscience, making undeliverable promises. At times they offer false and dangerous reassurance about lack of medical vulnerability. For example, 23andMe only tests for three variants of BRCA genes responsible for breast and ovarian cancer, although more than 1,000 BRCA variants are known to increase cancer risk. 90% of participants who carry a BRCA mutation would be missed by todays 23andMe test.

Families of wealth, who require safety, security and privacy at all costs, must reject these at-home testing products entirely. The infotainment they provide is not an acceptable trade-off for the risks they impose, especially compromised safety.

By contrast, the whole genome sequencing industry is strictly regulated, governed by law and operates with the highest evidence-based technical medical standards and protection requirements for those whom they serve. Whole genome sequencing presents a far superior alternative for families of wealth.

Sequencing itself is but the first step of a life-long genomics journey. Once you have been sequenced, interpretation of your raw genomic data is a dynamic process, constantly evolving. New and increasingly complex insights will become available at exponential speed. Professional guidance is an absolute requirement to optimize translation and enhance health.

Imagine the following scenario:

A highly educated, vital, healthy 35 year-old family member is appointed CEO of the core global family enterprise. He dies at his desk from an unanticipated cardiac event on the second day of his tenure.

Consider the profound emotional and social impact of such an event on his family, the family office and the larger family organization. And consider the economic risk of not anticipating such an event, especially as this silent medical condition might have been understood using currently available DNA medical science through whole genome sequencing (Predicting Sudden Cardiac Death, The Harvard Gazette, 16 November 2019).

THE FUTURE

Families of wealth, family offices and family enterprise will ultimately be enriched by the gifts of genomics. This disruptive, deeply intimate human science bodes an extraordinary future with elimination of malignant disease, enhanced well- being and healthy longevity.

With new knowledge and agency comes new fiduciary responsibility to protect the lives of those we serve. We must all wrestle with its challenges, especially its ethics. Arming families with a working knowledge of genomics and a formal blueprint for its ethical application allows them to shape their most powerful legacy and future.

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Dr. Ronnie S. Stangler: What Does Madonna Know About Her Genes That You Don't? Genomics and Its Impact on Families of Wealth | Horizons: Family Office...

Cars We Remember: The Rebel Machine by AMC and a rare 1971 Matador Go Machine – The Providence Journal

Q: I enjoy the nostalgia articles in my hometown newspaper The Gainesville Sun. The recent Cars We Remember section was really fun to read, and I enjoyed the AMC history of high performance. One AMC car you didn't mention was the 1970 Rebel Machine, and I'm wondering your thoughts on the Rebel Machine by AMC? How many were ever made and is it a worthy collector car?

Shawn S., Gainesville, Florida.

A: Shawn, I'm happy to tell you about the 1970 Rebel Machine and also a very rare 1971 AMC muscle car, too.

As I mentioned in the Cars We Remember special edition, by the time AMC released its pony and muscle car lineup during the latter part of the 1960s the company was way behind the performance youth movement that began in earnest with the 1964 GTO. And even though Chevy, Ford and Chrysler produced some really hot full-size muscle cars in 1961-1963 like the Chevy 409, Ford 390-406-427 and the MOPAR 413-426, American Motors was not in the performance ballgame at all.

To make things worse when it came to AMC completely missing this very profitable muscle car boom, the stuffed shirts at the board meetings decided to release newspaper advertisements that emphasized the only "race" AMC was interested in was the "human race." So, even though the baby boomer generation was clearly into excitement and muscle cars in a big way, AMC was not.

After finally relenting, AMCs mid-size performance started in 1967, when the good-looking Rebel SST hit the showroom floors. As a precursor to the Rebel Machine, the SST featured a 343-inch V8 with 280 horsepower and some interesting high-performance options like Carter 4-barrel carb, bigger camshaft, and even an optional 4:44 rear end gear. Still, a 343-V8 with just 280 horsepower was no match against the competition, like an Olds 442, Chevelle SS396 or a Ford Fairlane GT. It just didn't cut it.

But to answer your Rebel Machine question, immediately following AMC's compact size SC/Rambler American in 1969, which happened to be the hottest AMC ever to hit the roads and just 1,512 were ever built, AMC then decided to release the Rebel Machine in 1970. The Rebel Machine rode on a 114-inch wheelbase and was more in line with the Plymouth Roadrunner size of muscle car than the compact style SC/Rambler. The first 1,000 were painted red, white and blue, while the others could be ordered in any solid color.

Under the hood sat a 390-inch, 340-horse engine mated to the great shifting Borg Warner T-10 four-speed with a factory Hurst shifter. The suspension was beefed up with stiffer AMC station wagon springs in the rear, resulting in a nice "funny car style" rake. However, the raised rear resulted in some wheel hop under full acceleration with street tires at the drags. The car would run in the 14-second range at 90 mph, which was good back then for a street muscle car.

Other "The Machine" notables were a ram air type hood operated by vacuum with an integrated 8,000 RPM tachometer. In my opinion, the Rebel SST and the Rebel Machine were the best-looking AMC's of all, hands down.

As for longevity, the Rebel Machine was produced only one year, 1970, at a base price of $3,450. Thus, it is a very rare collector car and only 2,326 were ever built. Concerning pricing, a 390 Rebel Machine in excellent original or fully restored condition today will fetch an easy $50,000 and up according to NADA pricing. Even an average condition Machine needing some TLC should go in the $20,000 range, making it a desirable collector car.

Now for that other AMC performance car I mention above, which may well be the rarest AMC muscle car ever built.

Following AMC dropping the Rebel Machine from its lineup, a real sleeper popped up for just a bit of time in 1971 when less than 60 1971 AMC Matador two-door hardtops were delivered with AMC's "The Machine Go Package" option. The Go Package added either a 360-V8 at 290 horses or the preferred 401-inch V8 with 330-horsepower. The Borg Warner T-10 was again part of the package, along with dual exhaust, heavy duty suspension, 15-inch Goodyear Polyglas raised letter tires and a 3.90 rear end gear. As rare as this Rambler is, I've never seen one in person but it may well be the best of the mid-size muscle cars from AMC. By mid-1971, the option disappeared.

If you ever see a 1971 Matador with the 401 The Machine Go Package (valued at a top price of near $50,000) you are in the minority as very few survived the crusher. Thanks for your question.

Greg Zyla writes weekly for More Content Now and GateHouse Media. Contact him at greg@gregzyla.com.

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Cars We Remember: The Rebel Machine by AMC and a rare 1971 Matador Go Machine - The Providence Journal

Join Team Hackaday To Crunch COVID-19 Through Folding@Home – Hackaday

Donate your extra computer cycles to combat COVID-19. The Folding@Home project uses computers from all over the world connected through the Internet to simulate protein folding. The point is to generate the data necessary to discover treatments that can have an impact on how this virus affects humanity. The software models protein folding in a search for pharmaceutical treatments that will weaken the virus ability to attack the human immune system. Think of this like mining for bitcoin but instead were mining for a treatment to Coronavirus.

Initially developed at Standford University and released in the year 2000, this isnt the first time Hackaday has advocated for Folding@Home. The Team Hackaday folding group was started by readers back in 2005 and that team number is still active, so lets pile on and work our way up the rankings. At the time of writing, were ranked 267 in the world, can we get back up to number 30 like we were in 2008? To use the comparison to bitcoin once again, this is like a mining pool except what we end up with is a show of goodwill, something I think we can all use right about now.

You can get set up in five minutes. The software package is just a few megabytes and configuration is minimal:

Thats about it, just open FAHControl and the software will connect to the Folding at Home servers and request a Work Unit (WU) part of the protein folding math puzzle currently being solved. Once it has a WU the software will solve that unit and upload the result. Rinse and repeat and youre a worker bee in a super-computer thats distributed throughout the world.

The F@H project is seeing a surge of new computers on the network. Because of this you may run into a situation where no new WUs are getting downloaded. I experienced this on Wednesday morning and believe its simply caused by the buffer of work running out and needing to be replenished. The nice thing is you dont need to do anything, so just let your instance run and itll get to work when more is available.

The software does allow you to use your GPU for much more efficient calculations, but that setup may be non-trivial and beyond the scope of this article. I suggest you just get the client up and running and then look to configure GPU as a later step.

Are you making a difference? Yes! But of course metrics tell this message the best. You can see the team summary above. This statistics page includes a user summary showing 21 active users right now, including the hackaday_wrencher instance I added when working on this article which is just beginning to score points.

This group has over 1600 members right now but most are inactive. Can we reactivate those? Can we double that number? Grab those gaming rigs and let the electrons flow. Folding@Home has made a huge impact on research over the last twenty years and now more than ever we can build on that groundwork by joining in to fight this global pandemic.

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Join Team Hackaday To Crunch COVID-19 Through Folding@Home - Hackaday

How to Fight Coronavirus With Folding@home and a Gaming PC – How-To Geek

CDC / NVIDIA

Want to help in the battle against the novel coronavirus? You can put your PCs graphics processor to work with Folding@home. Youll join an army of computers running calculations to help scientists understand the virus.

Folding@home is a distributed computing project thats been around since the year 2000. Its named after protein folding. If you install the software and join a project, it will run in the background and use spare graphics processing (GPU) power to run calculations. Your PC will be one of the hundreds of thousands of PCs running these calculations, all working together.

The software has previously been used to help find cures to cancer, Parkinsons, Huntingtons, influenza, and many other diseases. Now, Folding@home is helping scientists understand the structure of the SARS-CoV-2 virus that causes COVID-19. As Folding@home director Greg Bowman explains, a better understanding of the virus could aid in the development of life-saving drugs.

In other words, you can put your PCs GPU to work crunching numbers that will help scientists better understand and fight the novel coronavirus.You can read specifics about how Folding@home is simulating the dynamics of COVID-19 proteins to hunt for new therapeutic opportunities on the projects website.

This work is GPU-dependent and requires NVIDIA or AMD graphics hardware. It will work best on computers with powerful graphics hardware.

To put your PC to work battling coronavirus, download the Folding@home installer and run it to install the software. Its available for Windows, Mac, and Linux. Well show how it works on Windows here.

Once youve installed the Folding@home software, youll be taken to thehttps://client.foldingathome.org/ page, where you can control the software on your PC. You can choose to fold anonymously or set up an identity.

If you set up an identity, you can track your work and earn points. You can even join a team with other people and compete to see who can earn the most pointsjust a bit of friendly competition.

However, you dont need to set up an identityyou can just select Fold as Anonymous and click Start Folding to begin.

To ensure youre helping with COVID-19 research, ensure Any disease is selected under the I support research fighting box. This is the default option. With it enabled, Folding@home will prioritize work related to the novel coronavirus.

Work may not be available immediately, and your client may work on other diseases like Alzheimers, cancer, Huntingtons, or Parkinsons while waiting for COVID-19 jobs. Leave it running in the background, and it will automatically start any available work.

The Folding@home software will remain running in the backgroundeven when you have the web page closed. It will automatically use any spare resources and get out of the way when youre using your GPU for other purposes, like playing a PC game.

Look for the Folding@home icon in your computers notification area (system tray) to find options, pause it, or quit the software and prevent it from running.

If you decide you no longer want to participate, head to the Uninstall or change a program list in Windows and uninstall the FAHClient program.

Even NVIDIA has called for gamers to install Folding@home and donate any spare computing power they might have. Computers all over the world are joining the fight.

For more information, take a look at thisFAQ about the SARS-CoV-2 projects in Folding@home. Youll also find updates on Folding@homes news page.

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How to Fight Coronavirus With Folding@home and a Gaming PC - How-To Geek

Researchers turn to PC gamers for help with COVID-19 – GamesIndustry.biz

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PC gamers are being asked to donate their unused computational power to help researchers better understand the novel coronavirus (COVID-19).

Folding@home is a distributed computing project for disease research which uses idle resources to simulate protein folding.

By downloading Folding@home, PC gamers can help researchers develop treatments for COVID-19, which has so far killed over 8,000 people and caused global disruption.

"The data you help us generate will be quickly and openly disseminated as part of an open science collaboration of multiple laboratories around the world, giving researchers new tools that may unlock new opportunities for developing lifesaving drugs," said Folding@home director Greg Bowman in a post detailing the project.

Early projects are geared around understanding how the virus interacts with human host cells, and developing new antibodies to disrupt it.

Folding@home intends to make the data readily available to researchers and the public.

"While we will rapidly release the simulation data sets for others to use or analyse, we aim to look for alternative conformations and hidden pockets within the most promising drug targets, which can only be seen in simulation and not in static X-ray structures," said Folding@home computational chemist John Chodera.

"We hope that these structures -- once validated by emerging compound screening data -- could help direct the virtual screening campaigns or the targeting of new pockets for which atomistic structures were not yet available."

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Researchers turn to PC gamers for help with COVID-19 - GamesIndustry.biz