Movin’s predictable logistic flow will give MSMEs peace of mind: UPS’ Ufku Akaltan – Economic Times

Posted on July 8, 2022 by Danzig

Rahul Bhatia-led InterGlobe Enterprises and Atlanta-based logistics major UPS rolled out their logistics venture, Movin, in the capital recently. Aiming to tap the logistics industry in a more predictable, transparent and reliable manner, Movin boasts of helping businesses get more competitive in this space.

With its services that include day-definite as well as time-definite solutions, the venture claims to give businesses better predictability and planning for their operations. Ufku Akaltan, UPS President-Indian subcontinent, Middle East and Africa, and JB Singh, Director,

The Economic Times (ET): Why did you want to do this JV with InterGlobe for the Indian market? What was the idea behind it?Ufku Akaltan (UA): A typical joint venture brings in unique and a wealth of experience to the Indian market. Also in the aviation, hospitality and travel industries, InterGlobe is second to none. They have built enduring brands and they have connected these brands to customers. They were a perfect partner for us to bring Movin to the market together.

ET: Are you creating any physical infrastructure in India?UA: Movin is currently building and expanding its network, starting with our people, technology, processes and also partners. Long-term leases are a part of this game plan to make sure the network is aligned to our customer needs to provide a predictable and reliable service.

ET: How will Movin help in driving more efficiencies in logistic operations for Indias MSME sector?UA: Movin, with its product portfolio and technology driven processes, will be providing MSMEs the peace of mind for a predictable, controllable, plannable logistic flow. It is going to help the MSMEs reach their customers faster, which will improve their chances to grow and, in essence, enhance their cash flows. They will also have a much easier access to global trade and when customers are capable in a domestic environment, they start seeking opportunities to start exporting. At that point, they will integrate with our global network which will further help them grow their business.

ET: Movin seeks to make the supply chain more predictable which, in effect, will help a lot of businesses in the present environment. What kind of technological processes do you have in place to make this possible? JB Singh (JS): Movin will focus on its people, driving commitment through training, engagement and empowerment. Culture drives business, so that is fundamental and becomes a bedrock of our business. We have built the whole indigenised stack in technology. It is almost paperless where you can upload KYCs or any documentation seamlessly. It is really simple to use, which means even someone from a tier-II or a tier-III place can use it. We have a very large robust call centre and we are going to promise single call resolution. There is a whole repository where customers will have their own data on billings and everything which they can access in time.

It is all accessible to customers and it is linked to our entire back office. Everything that we see, the customers can see as well and so it is entirely transparent. Even aspects like our HR policies and how we manage our people everything is integrated into that.

A more important part is the processes. If there are solid processes in place, it drives efficiency and that drives value.

ET: The supply chain crisis has affected economies across the world. In the aftermath of such a crisis, how can such a brand help to alleviate that in some way? UA: When you have predictability and a reliable service from a logistics partner, that helps you surgically support your own customers with such a product. We

Movin's predictable logistic flow will give MSMEs peace of mind: UPS' Ufku Akaltan - Economic Times

Opinion: The unsung heroes of Ukraine: Photographers Evgeniy Maloletka and Mstyslav Chernov, who captured Mariupol’s pain – The Globe and Mail

Posted on July 8, 2022 by Danzig

Associated Press photographer Evgeniy Maloletka points at the smoke rising after an airstrike on a maternity hospital, in Mariupol, Ukraine, on March 9.Mstyslav Chernov/The Associated Press

The Globe and Mail is spotlighting some of the unsung heroes of the war in Ukraine, who are doing their part amid Russias invasion. Other pieces in this series include recognition of the doctors, the farmers and the public servants

Christian Borys is the founder of Saint Javelin, a company that has donated more than $1-million from sales to Ukraine since the start of the war, and a former reporter based in Kyiv from 2014 to 2018.

In February, early in Vladimir Putins unprompted and illegal attack on Ukraine, Russian troops quickly advanced from the south and from the east until they were on the footsteps of the Ukrainian city of Mariupol.

As the Russian military began its siege of the now-infamous port city, there came a moment of reckoning for the foreign aid workers, journalists, photographers and others staying in hotels across the city: whether they should stay or leave.

Most left. But Evgeniy Maloletka and Mstyslav Chernov, both veteran Ukrainian journalists who have covered the war with the Associated Press for years, decided to stay, because they understood what the Russians were about to do to Mariupol. They decided that their job, no matter the personal risk, was to tell that story to the world.

Since 2014, theyve both seen firsthand the depths of depravity within the Russian military. They understood what the Russian military can do and does to journalists who expose their horrors. And they knew that the Russian military would be only too happy to wipe Mariupol off the face of the Earth, killing thousands of civilians, if it meant achieving Russias goals.

Yet they stayed. And by staying the only international journalists who remained in the city, over the course of their month there they became the first journalists to shock the world with the true face of Russia.

With Russias relentless shelling knocking out power throughout the city, they used generators to power their phones and laptops so they could upload their work to Associated Press editors around the world, using whatever weak internet signal was left.

And that work was gruesome and heartbreaking. In late February, they started to send photos of lifeless Ukrainian children in Mariupols hospitals whod been killed by Russian artillery and air strikes. The photos were almost impossible to look at, but Mr. Maloletka and Mr. Chernov bore witness at those hospitals, spending hours with those medical teams, watching countless children and civilians die so that the rest of the world could see what Russia was doing.

The psychological effect of what they saw and experienced is impossible for almost anyone to understand, but they did it day in and day out. They experienced danger themselves, too; Mr. Chernov said the Russians were hunting them down. They had a list of names, including ours, and they were closing in, he wrote.

Over the course of the nearly three-month siege, Mariupol became the home of a humanitarian crisis with thousands of reported deaths. In May, the city fell under Russian control.

The two of them never fired a bullet, but in a very real way, I think that those two men helped to save Ukraine. They may not have fired a bullet, but their photos and videos helped galvanize the worlds support. In my mind, the country still fights on today, in part because of their cameras.

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Opinion: The unsung heroes of Ukraine: Photographers Evgeniy Maloletka and Mstyslav Chernov, who captured Mariupol's pain - The Globe and Mail

How to Resize an Image in Photoshop – PetaPixel

Posted on July 8, 2022 by Danzig

Resizing images in Adobe Photoshop sounds like it should be a trivial and simple operation, and for many uses and users, it is. Its when one starts looking closely at the details in a resized image that it becomes apparent you should be looking into the options of the resize image dialogue box.

In the past resizing to larger sizes was often performed on image files in order to make large prints. With the higher pixel count of current cameras and high-end mobile devices, resizing larger might not seem that necessary and maybe it isnt for many users. If, however, youre looking to produce the best quality prints from your image, resizing before printing might be in order and it doesnt necessarily mean increasing image size.

Another resize scenario that I personally run into nearly every day is prepping images for posting to social media. In this case, Im reducing the size of images in Photoshop before uploading them to social media and my own website. Other reasons for resizing images include submissions for publications, insertion into videos, and many more.

First, well start with a basic, barebones step-by-step look at how to resize an image. The steps are as follows:

Now lets do a deeper dive into the options available when resizing any image.

The Image Size dialogue box (Figure 1) looks pretty simple but theres a bit more here than meets the eye. Lets take a tour of the settings and options starting with the preview window.

In Figure 1 we see the Image resize dialogue box as it normally appears in Photoshop. It can be called by going to the Image > Image Size item in the main menu or by pressing Control+ALT+I in Windows or CMD+ALT+I on Mac.

Starting at the left we have the preview window which by default shows a 100% view of the image being resized. This view will update as one changes the parameters of the resize action to be performed. I highly recommend leaving this setting at 100% as it will provide the most accurate preview of the image quality after the resize is completed.

This preview window by default is a bit small but since 2013, Adobe added the ability to enlarge the entire Image Size dialogue box. It is not readily apparent but you can grab the sides and corners to enlarge the view. You can see in Figure 2 how Ive enlarged the view so now at 100% we can see all of Stephanies face instead of just the small portion visible in Figure 1.

To the right of the preview window are some details about the image starting with the image file size. In this case, the file size is based on an uncompressed file so if you were to save this file as TIFF with compression turned off, it would be 34.4Megabytes in size. Obviously, when the image is exported as a JPEG it would be much smaller in size.

Below this, we have the image dimensions which are by default displayed in inches but might be different if you have changed this in the past. I usually size by pixels which can be seen as my default dimension setting in Figure 3. Other options are percent, inches, centimeters, millimeters, as well as points and picas. The latter two are most familiar to the desktop publishing crowd

Next we have the Fit To options seen in Figure 4. This is a pull-down list with some commonly used image sizes for web use, desktop publishing, and photo print sizes. Keep in mind these presets will not crop an image so if you, for instance, use the preset for 5 x 7 inches and the image doesnt match those proportions it will only match one of the dimensions and let the other adjust to fit the original proportions of the image.

Just below the Original Size option in the pull-down list is Auto Resolution. It might sound like Photoshop will somehow be able to guess the desired resolution for which you are needing. However, it is not reading your mind (yet!). Figure 5 shows the settings that are displayed when selecting this option.

Auto Resolution is basically there to do some math for you when your image will be output via the color separation process (or halftone in the case of grayscale images). If you are having to resize your image for high-quality book publishing or other similar types of output, the printing service will likely provide you with the lines per inch setting you should use. Of course outside the United States you may find they use lines per centimeter and thankfully Photoshop provides this option.

It may also be that you have a printer in your office/studio/lab that might provide a lines/inch type setting recommendation, so check your manual to see if this is the case for the best quality output from your printer.

Three base options are available for draft, good, and best quality. For the final output, I would certainly choose the Best option. Again your service provider might request a draft quality version for testing.

If you have a setting that you need to use frequently but isnt listed in the default options you can use Custom to create one using the Save Preset option. Saved settings can be recalled using the Load Preset option. You will see that if you change the width/height settings the Fit To dialogue will change to Custom (Figure 6) and then this setting can be saved as a new preset.

Now were getting to where the real action is. The width and height fields are where you will make the changes to the image size. In Figure 7, you can see that to the left of the width and height input fields there is a vertical chain link icon (outlined in red). Clicking this icon toggles on and off the link between the two dimensions.

When locked, changing one dimension will cause the other to be changed in order to maintain the original proportions, or aspect ratio, of the image. When turned off these two dimensions can be changed independently. This is often not desirable as it will distort the newly resized image but there are times you might want to do this, thus the option to do so.

Before making changes to the values in the width and height fields you may want to change the type of value youll be modifying. You can do this using the pull-down menu highlighted in yellow in Figure 7. You can see how the options will appear in Figure 8 below.

One thing you might find a bit redundant is that despite the fact that there is a separate pull-down list for both the width and height dimension type, they will almost always be the same. For instance, you cannot have one display in inches and the other display pixels even if you unlock the values using the link icon. The exception is the columns option, which well look at shortly.

Of course, now comes the part where you need to decide which of those values shown in Figure 8 you need to use. Percent is pretty self-explanatory as it simply increases or decreases the image dimensions based on the percentage you input. Keep in mind that there are limits here and you cant set a percentage that will increase the pixel dimensions larger than 300,000 pixels on the long side.

It may seem like the percentage option is rather limited in scope of use as you often need specific pixel/inch/cm dimensions. However, years (and years) ago it was used quite often to enlarge images. Many Photoshop users swore by the method of using successive 10% image size increases to create cleaner and more detailed image enlargements than simply jumping to say 150 or 200 percent image resizes. The more advanced algorithms that are now in Photoshop do a pretty good job. Still, you might try that technique out for yourself and compare the results.

Resizing by pixel dimensions probably runs neck and neck with inches (or centimeters) for the most often used parameter. This certainly is related to needing specific output sizes for viewing on webpages, mobile applications, and other electronic displays.

Note that when resizing for electronic displays, the Resolution parameter will generally have no effect on how the image will look on your computer or mobile device screen. This is because a 400300-pixel image displayed at 100% on a screen will remain 400300 pixels (see Figure 9). It doesnt matter if the resolution is 72ppi or 600ppi. This is because your screen has a fixed number of pixels and as such, the resolution figure means nothing in this case when viewing images, usually.

Some desktop publishing and layout applications may display an image differently based on resolution because they are designed to preview the output to print. As such, Pixels Per Inch do make a difference in this case. The same applies when outputting to print in Photoshop.

This brings us to the remaining value types available for resizing. These include inches, centimeters, millimeters, points, and picas. Using any of these values allows you to resize to a specific output size for printing. For output to a printer, you would typically use the inches or centimeters options. Millimeters could be used here as well. Points and picas are going to be typically used by those in desktop publishing and other publication development tools.

When using these physical print/output values, resolution does become important. While 300ppi is often used for a lot of printing situations, it may not necessarily be the best. 300ppi will often provide very good results for print sizes like 46 up to 1620 inches and maybe even a bit larger. However as output size grows, the expectation is that the viewer will be further away from the image. This is often why large prints, 3040 inches in size, for instance, can be printed at 180ppi and even much less for billboard size prints. Unless someone gets very close to the image, the quality will be very difficult, if not impossible to see.

If you are sending your work to be printed, the service will often offer recommended output resolutions as well as some other settings. If you are using your own printer, the manual might offer some preferred settings based on the output size.

The last item in the list of values is columns. I mentioned columns earlier as the one value you can set in width or height that can be different from the other dimension type. Like picas and points, columns are going to be something familiar to those who layout documents and work in desktop application tools like InDesign. Ok, so what is the actual value of a column when using this value? So glad you asked.

Column size is set in Photoshops preferences and can be found under the Units & Rulers section. By default, the column size is set to 180 points (2.5 inches). Column and gutter width can be adjusted in the area highlighted in red in Figure 10.

This dialogue box also offers some other settings you might want to adjust to suit your workflow. For instance, I prefer to have my rulers set to pixels and you might want to have new images default to a different print resolution than 300ppi.

Before we get into the various resampling options, I want to point out that the terms resize and resample are not necessarily interchangeable. Technically, resizing is simply adjusting the printable output dimensions and as you change the size in inches, the resolution is simply adjusted to fit all the available pixels into the new printable area. You can see this by unchecking the resample box and adjusting the inches value. The resolution will change to fit.

Likewise, you can change the resolution value and the width and height will change accordingly. You will even see that once you uncheck the resample box, the Width, Height, and Resolution labels are all linked and the ability to unlock is not possible. This is because pixels are not being added or subtracted from the image. Of course, if you do need to adjust the actual pixel dimensions of an image, then youll need to check the Resample box if it isnt already.

Here is a brief overview of what the different resampling methods do:

By default, Photoshop will choose what it feels is the best resample algorithm for the resize type you are performing. For enlarging, or adding more pixels, Photoshop is defaulting to Preserve Details where reducing image size uses Bicubic Sharper. The settings Automatic uses could change at any time with future updates so when you get a new update I would check to make sure.

Note: If you dont see the option for Preserve Details 2.0 this could be because you have not enabled it in the preferences. First introduced in Photoshop CC 2018, the Preserve Details 2.0 feature falls under Technology Previews in Photoshops preferences (Figure 13). This is still the case in version 23.4.1 which Im using at the time of this writing. Perhaps in a future version this will get moved into a regular feature.

To take the ambiguity out of the result I would set the method I use manually from the pull-down list. In Figure 14 I have an example image where I doubled the pixel dimensions of the photo using the three different options for enlargement. The large image is a crop at 100% of the original image. The three images below are 100% views of the same point in the image after doubling the pixel count. You can click on the images to see a full-size view of each. At the reduced size to fit into this article, the images are too small to see much if any difference.

I find that Preserve Details 2.0 does the best overall job for clean and natural-looking output. The original Preserve Details does a good job but it tends to over-sharpen a little which creates some halos if you look closely. Bicubic Smoother is no slouch itself and without having the other options side by side for direct comparison. It looks very close at first glance to the Preserve Details options but the fine details are a little mushy and looking at the softbox reflection in the eye you can see some detail in the softbox grid is lost.

For reducing image sizes the Bicubic Sharper does a good job but I have to say most of the options look very good when reducing an images size. If you find that Bicubic Sharper is a little oversharpened, you can try the regular Bicubic option. However, I would still look at Preserve Details 2.0 when the reduction is only between about 1 to 30% of the original dimensions. As always you might just experiment as the content of your image may look better in one approach or the other.

The Bicubic options (Smoother, Sharper, and regular) have a distinct advantage over Preserve Details in that they are much faster to process. If you are needing to resize a large batch of images for proofing or have any other situation where the absolute highest detail isnt necessary, I would use the bicubic options. On my Dell XPS 15 9500 (i7-10875H), upsizing a 42MP image by 200 percent took six seconds with Preserve Details 2.0 and two seconds in the original Preserve Details. Using Bicubic Smoother was pretty much instantaneous.

For illustrations and similar types of images, Nearest Neighbor can do a good job at preserving the solid colors and crisp edges you may find in those types of files. However, it can produce some strong aliasing so watch out for that. Bilinear uses a weighted averaging based on nearby pixels and is the least accurate option. It is also very fast but with modern computers, this advantage really isnt relevant.

One last option in the Image Size dialogue box is in the upper right-hand corner and is just a small gear icon as seen in Figure 15. Scale styles might not sound interesting but if you work with layer styles such as drop shadows, strokes, etc, this option is huge. Layer styles such as drop shadow contain their own set of parameters that dictate their appearance. If the Layer style isnt properly scaled to match the resampled overall image, the effect of the style can be ruined. Having this option for Photoshop to automatically adjust, or not, the Layer Styles in the resampled file is very useful.

Before wrapping this up I wanted to touch on the use of the terms PPI and DPI. These often seem to get used interchangeably but they really shouldnt. PPI refers to the number of pixels per linear inch. This determines how many of the images pixels will be present in the physical space of a print. PPI as it applies to a digital image being displayed on an electronic display doesnt have a specific meaning. In most cases, it has no bearing on how the image is displayed on a screen since when it is viewed at 100% size, it will display the image pixels at a one-to-one ratio to the displays pixels.

Why does this matter?

Sometimes people feel the need to match the PPI setting of their image to the DPI specification of their printer. With printers capable of outputting at DPI levels like 2,400 or 4,800, it can seem like a good idea to upsize your image PPI to match the printer DPI. The fact is that there is usually not a direct correlation to output resolution here. These high DPI output printers use very tiny dots of ink to mix together to create more accurate colors and a wider variety of ink density. As such this is typically not going to help and can actually make the output worse. Plus it can have the detrimental side effect of creating huge file sizes that can be difficult to work with. Instead, stick with your printer manuals recommendation.

So it turns out that resizing images may not be as simple as it appears. Of course, this depends on how important the quality of the final output is to the image usage. I regularly hear from fellow photographers that they are often disappointed in the quality of the images they upload to social media sites like Instagram and Facebook. Often this comes from the fact they are uploading very large images and letting the servers at these services resize the images as they upload. This is usually due to the fact those servers use simple and fast approaches to resizing the images since processing time is money.

Remember earlier how I pointed out how resampling using Preserve Details 2.0 took several seconds vs Bicubic which was nearly instant? If you had to process 350,000,000 photos a day like Facebook does on average, youd probably want to go for the fastest option too. By resizing your images to the recommended size(s) for the site you are using, you improve the quality of the images after they upload.

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How to Resize an Image in Photoshop - PetaPixel

Molecular Medicine (M.Sc.) – Georg-August-Universitt Gttingen

Posted on July 8, 2022 by Danzig

The English-language Master's degree programme in Molecular Medicine is directed at highly motivated students from home and abroad who are interested in the subject. The prerequisite is a Bachelor's degree with a focus on either natural sciences or molecular medicine. The degree programme will provide deeper knowledge of topics relating to molecular medicine and clinical theory such as immunology, oncology, genetics, pharmacology and cell biology. In addition, there are also three laboratory internships, each lasting eight weeks. A Master's thesis will be written within six months.

Name of program: Molecular MedicineDegree: Master of Science (M.Sc.)Length of program: 3 semestersProgram start: winter semester onlyApplication deadline: May 30th for winter semester 2021/22 Prerequisites: B.Sc. in Molecular Medicine or a related fieldAdmissions: limited spaces available (apply directly through faculty)Language requirements: English (certification mandatory)

A proof of measles protection is required for enrollment. The form must be completed by your primary care physician.

If necessary, please use the time between your application and enrollment to get vaccinated or to refresh your vaccination status. The short period of time for acceptance after admission is usually not sufficient for this.

For inquiries, please contact the Office of the Dean of Medical Studies studiendekanat@med.uni-goettingen.de.

Program OverviewThe eighteen-month Masters program in Molecular Medicine expands upon the scientific and medical knowledge basis acquired in Bachelor programs and explores in depth the molecular aspects of medicine. Its goal is to train students thoroughly in an area of application of molecular medicine. It should enable students to engage in independent and creative research at the crossroads of medicine and basic science.

Program StructureDuring the first year, students attend the course ?Molecular-pathological aspects of organ systems?, which is designed to heighten their understanding of the interaction between clinical and molecular science. In other obligatory module courses particular aspects of molecular immunology, bacteriology, human genetics and oncology are treated. The final six months are to be devoted to work on a master?s thesis.

A graduate of the Master?s program in Molecular Medicine should have solid knowledge of the methods of scientific research as well as be able to apply a wide spectrum of molecular-medical methods to provide concrete solutions to scientific problems.

Our graduates secure positions in all areas of medical research, laboratory diagnostics, and medical biotechnology, in both the academic and the commercial sectors. Places of employment include: clinics (molecular and biochemical diagnostics, clinical research, etc.); government agencies (criminal investigation offices, public health departments, commercial regulatory authorities, environmental protection agencies, medical associations); places of academic research (universities, Max Planck Institutes and other large research institutions); industrial settings (biomedical technology, production and quality control, basic research and development, publishing, marketing, administration); private laboratories (molecular diagnostics and analysis, environmental protection); and other institutions (ministries, research advancement organizations, technology transfer facilities).

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Molecular Medicine (M.Sc.) - Georg-August-Universitt Gttingen

School of Medicine – Biochemistry and Molecular Genetics | UAB

Posted on July 8, 2022 by Danzig

Committed to exploring new frontiers in basic and translational research.

The Department of Biochemistry and Molecular Genetics is an integral part of the vibrant biomedical research community at the University of Alabama at Birmingham (UAB). UAB ranks among the top public institutions of higher education in terms of research and training awards. Research conducted by the faculty, staff, and students of the Department of Biochemistry and Molecular Genetics is currently supported by more than $7.1 million per year in extramural, investigator-initiated grants.

The Department of Biochemistry and Molecular Genetics carries out cutting-edge basic and translational research. Research strengths in the department includes cancer biology, chromatin and epigenetic signaling, metabolism and signaling, regulation of gene expression, structural biology, DNA synthesis and repair, and disease mechanisms.

Graduate students and postdoctoral fellows in the Department of Biochemistry and Molecular Genetics are trained to carry out hypothesis-driven research using advanced research techniques. This training will prepare our graduates for a career in not just biomedical research, but also in other diverse fields that require critical thinking. Our faculty also proudly trains professional (MD, DDS, & DO) students, as well as undergraduate students at UAB.

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School of Medicine - Biochemistry and Molecular Genetics | UAB

Married Couple are ‘Heart and Soul’ of Willed Body Program – University of Arizona

Posted on July 8, 2022 by Danzig

Medical students around the country start their journey to become physicians by studying the human body in gross anatomy labs, where they are reminded that real people volunteered their bodies to serve as educational tools to train them to help others.

Its no different at the University of Arizona Colleges of Medicine Tucson and Phoenix. The Tucson-based Willed Body Program annually accepts 150-200 whole body donations, which are embalmed and put in cold storage for use by both colleges for up to two years. Afterward, the remains are cremated and ashes returned to the families or spread in nearby mountains.

The people of Arizona are incredibly generous in this respect, because I know some willed body programs do have issues with not enough donors. And we never do, said Jean Wilson, PhD, program director, anatomy instructor, professor of cellular and molecular medicine, and BIO5 Institute member. We always have enough every year to supply the needs of the college and beyond.

The Willed Body Program serves more than just the Colleges of Medicine Tucson and Phoenix. It also supplies bodies for the A.T. Still University School of Osteopathic Medicine in Phoenix and nursing programs at the UArizona College of Nursing, Arizona State University and Northern Arizona University.

Currently, about 9,000 Arizonans have been issued willed body donor cards through the program that was founded in 1967.

Dr. Wilson credits the programs success in large part to the respectful, professional tone set by its funeral directors, Jared and Kat Alvarado. The husband-and-wife team work with donors, the families, faculty, physicians, nurses, students and others who benefit from the program.

Theyre unbelievable, Dr. Wilson said of the Alvarados. In the 32 years Ive been affiliated with the program, weve had people who are fine. But between the two of them, Kat and Jared are exceptional. Theyre so good with the donor families and the donors. They know exactly the right things to say. Theyre very gentle and empathetic. We are super lucky to have them.

Jared has been with the program 12 years, and Kat for seven. Both hold associates degrees in mortuary science and served three-year apprenticeships before being licensed as morticians.

Ive worked at places without an in-house willed body program, where you deal with a third party, said James Proffitt, PhD, College of Medicine Tucson lead instructor for the gross anatomy lab and cellular and molecular medicine assistant professor. Having two trained funeral directors and morticians people who really understand the process of grief and dying makes this so much more community oriented, humanistic, engaging and empathetic with what donors and students need.

I take the same approach as if I were at a funeral home, but feelings surrounding death are slightly less intense. The donors who participate in the Willed Body Program want to be here and most express their excitement at being able to contribute to medical education.Kat Alvarado, UArizona Willed Body Program funeral director, embalmer and coordinator

The donor families are very used to working with Kat and Jared, Dr. Proffitt said. They understand their best interests are looked out for by those two. It creates this kind of community, this family of donors. And this is something I try to impress on our students. These donors arent people from somewhere else. Theyre Arizonans. Theyre our neighbors.

Kat said her interest in the field was piqued in college, when she worked as a funeral home service attendant. She later served as an embalmer, cremationist and funeral director for a funeral home.

At UArizona, she said, I take the same approach as if I were at a funeral home, but feelings surrounding death are slightly less intense. The donors who participate in the Willed Body Program want to be here and most express their excitement at being able to contribute to medical education.

Unlike his wife, Jared said he sort of fell into his career as a funeral director.

After he graduated from high school, he took a job answering the phone at a funeral home. He started working with decedents his second day on the job. He went to mortuary school in Dallas, apprenticed in Texas and Arizona, and served as a crematory operator and embalmer before joining the Willed Body Program.

Death is hard on the families. But, at the same time, its great to hear how proud they are of their loved one donating their body to students for education, Jared said of what families say when he and Kat pick up a donated body. They hear similar comments at an annual willed body ceremony that offers donor families a chance to honor their loved ones.

Nearly 400 people attended the Willed Body Memorial Service in March. Among the speakers were the Alvarados, Dr. Wilson and medical students who expressed their gratitude for the donors beautiful and lasting gift to help them better learn their craft.

Jared does outreach to local high schools, talking to students about his experiences while encouraging others to follow in his footsteps.

My outreach to youth is important to me, he said. I wish I had someone who came to my high school to speak about these types of professions. Its my way of helping out as best I can.

The Alvarados are more than morticians. They also help fulfill continuing education needs for faculty physicians and nurses. In 2015, Jared Alvarado won the College of Medicine Tucsons Appointed Personnel Lura Hanekamp Award of Excellence for the part he plays in education for students, physicians and health professionals.

In 2019, Kat won a UArizona Individual Award for Excellence for her dedication to handling the programs administrative needs as Willed Body Program coordinator.

Jared also helps write academic papers related to the program, including a 2019 article on donor bodies used for students teaching students as a novel solution to time demands on doctors.

The program also hosts training opportunities for other medical professionals where staff need to understand human anatomy, including paramedics, emergency medical technicians and military health personnel. Jared assists in some training, including non-UArizona instruction for Davis-Monthan Air Force Base staff.

It usually is just myself and their instructors, so Im able to show them techniques and things Ive learned as part of the College of Medicine, he said.

Both are on call 24/7 to ensure the Willed Body Programs ongoing success, whether that involves working with instructors to help design specific training or traveling across the state to pick up donor bodies from a family or funeral home.

Thats important, Dr. Proffitt said, because donors bodies are the canvas upon which students and trainees learn to practice their art as healers. Without them, there is no healers art.

Married Couple are 'Heart and Soul' of Willed Body Program - University of Arizona

Ulcerative Colitis (UC) Treatment Market: Rise in Number of Patients with Ulcerative Colitis Globally to Drive the Market – BioSpace

Posted on July 8, 2022 by Danzig

Wilmington, Delaware, United States, Transparency Market Research Inc.: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that involves the chronic inflammation of the colon or large intestine. It causes ulcers (sores) and long-lasting inflammation in the digestive tract and typically affects the innermost lining of the colon and rectum. The symptoms of the condition include dehydration, pus or blood in diarrhea, belly pain, fever, and urgent and painful bowel movements. Though the exact cause of the condition has not been identified, abnormal activation of the immune system in an individuals intestines leads to ulceration portions and chronic inflammation of the colon.

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Ulcerative colitis can be classified into ulcerative proctitis, proctosigmoiditis, left-sided colitis, pancolitis, or universal colitis and fulminant colitis according to the degree of inflammation and its location. Inflammation in ulcerative proctitis is limited to the rectum. In proctosigmoiditis, inflammation is observed in the sigmoid colon and rectum. Inflammation from the rectum extending to the left colon takes place in left-sided colitis. In universal colitis or pancolitis, inflammation affects the entire colon. Fulminant colitis is a severe but rare form of universal colitis.

Rise in number of patients with ulcerative colitis globally is a prominent factor driving the expansion of the ulcerative colitis treatment market. According to a report published in the Crohns & Colitis Foundation of America (CCFA), around 1.6 million people in the U.S were affected with IBD in 2014, with 70,000 new cases reported each year. Of the total number of people with IBD in the U.S, 907,000 had ulcerative colitis.

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The number of new cases of UC are reportedly rising rapidly in newly industrialized countries in Eastern Europe, South America, Africa, and Asia. Increase in use of antibiotics, westernized dietary patterns, rise in exposure to pollution, and improvement in hygiene are some of the factors playing a pivotal role in the increased incidence of UC in developing countries as compared to developed countries. The highest increase in the incidence of these conditions has been reported in countries such as Japan, India, China, etc.

New collaborations and partnerships between biopharmaceutical companies is also helping in providing novel treatment options for the management of UC. In February 2018, Cook Biotech Inc. entered into a new partnership with Regentys in order to develop a new treatment for UC. As per the agreement, Cook Biotech will develop and produce Regentys ECMH Rectal Solution (extracellular matrix hydrogel), a patented and non-surgical hydrogel therapy for patients suffering from ulcerative colitis. In December 2017, Roche announced a collaborative agreement with Boehringer Ingelheim for the discovery and manufacture of novel LNA (locked nucleic acid) oligonucleotides used in the management of inflammatory bowel diseases such as UC.

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The global ulcerative colitis treatment market can be segmented based on treatment, end-user, and geography. In terms of treatment, the ulcerative colitis treatment market can be divided into

non-surgical and surgical. The non-surgical segment can be further classified into 5-aminosalicylic acid, corticosteroids, immunosuppressants, and others. Based on end-user, the ulcerative colitis treatment market can be divided into hospitals, ambulatory surgical centers, and clinics.

In terms of geography, the global ulcerative colitis treatment market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America dominates the global ulcerative colitis treatment market due to a sizeable population with UC along with continued funding for development of new therapeutics for the treatment of the condition.

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North America is followed by Europe. Infusion of fresh capital by private investment firms in companies involved in the research of innovative treatment methods for UC is likely to propel the ulcerative colitis treatment market in Europe. In May 2018, Sublimity Therapeutics Limited, a specialty pharmaceutical company, announced that it had successfully raised US$ 64 Mn from investment firms led by Longitude Capital, OrbiMed, and HBM Healthcare Investments. The proceeds from the capital raised will be used for the clinical development of STI-0529 for the treatment of moderate to severe UC.

Prominent players operating in the global ulcerative colitis treatment market are Boehringer Ingelheim, Cook Biotech Inc., Pfizer, Inc, Regentys, and Sublimity Therapeutics Limited.

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Ulcerative Colitis (UC) Treatment Market: Rise in Number of Patients with Ulcerative Colitis Globally to Drive the Market - BioSpace

The pandemic has eroded Americans’ trust in experts and elected leaders alike, a survey finds. – The New York Times

Posted on July 8, 2022 by Danzig

Dr. Rochelle Walensky, director of the Centers for Disease Control and Prevention, testified before a Senate hearing in June.Credit...Haiyun Jiang The New York Times

As the coronavirus pandemic entered its third year, the American public had lost much of its trust both in public health experts and in government leaders, and was less worried than before about Covid-19, according to a survey conducted in early May and released Thursday by the Pew Research Center.

Confidence ratings for public health officials, like those at the Centers for Disease Control and Prevention; for state and local elected officials; and for President Biden fell in a range from 43 percent to 54 percent in the survey much lower than during the early stages of the pandemic.

The survey found a wide partisan gap in attitudes. Overall, 52 percent of respondents said that public health officials had done an excellent or good job at managing the pandemic. But while 72 percent of Democrats in the survey said they felt that way, only 29 percent of Republicans did.

Democrats were also more likely than Republicans 67 percent to 51 percent to say they had at least some confidence in how prepared the nations health care system was to address a future global health emergency.

Dr. Yvonne Maldonado, a pediatric infectious disease physician at Stanford Medicine who chairs the American Academy of Pediatrics committee on infectious diseases, said the pandemic only widened the countrys partisan divide over those issues.

I think that mistrust in government and politicians, and even to a certain extent science, started well before the pandemic, and it just was exacerbated, Dr. Maldonado said.

Pandemic fatigue and a growing notion that Covid is now a part of everyday life probably played a role in the changing public attitudes identified in the Pew survey, according to Dr. Robert Wachter, a professor and the chair of the medicine department at the University of California, San Francisco.

I think peoples thinking is very much influenced by the fact that the chances youre going to die of Covid have gone down substantially on a per-case basis, Dr. Wachter said.

Public confidence in medical centers and hospitals remained high: Eight out of ten respondents said those institutions were continuing to manage the pandemic well, a small decline from 88 percent two years ago.

The survey found that Americans have grown less worried about catching the virus or unintentionally spreading it to others. Most respondents said they thought the worst of the pandemic was over, and only about a quarter saw the coronavirus as a significant threat to their personal health, down from 30 percent in January.

The average number of new confirmed cases reported daily across the United States surged to record highs in January, driven by the Omicron variant. The surge receded swiftly as the winter ended, but the average started to rise again in the spring. In recent weeks since the survey was taken, the number of new confirmed cases has been around 100,000 a day, according to a New York Times database.

Those figures are thought to understate the true number of infections, however, because of increasing reliance on at-home testing, the closings of mass testing sites and reduced frequency in data reporting by states. New deaths have fallen significantly since the winter surge, and Covid now kills fewer than 400 people daily in the United States.

Though many people are still becoming infected, survey data shows that public concern about the virus has declined substantially. The Pew survey found that 76 percent of respondents in May thought the worst of the pandemic was over, compared with about half in January.

Thats the first time during the entire outbreak that weve had a majority of Americans saying this, said Alec Tyson, an associate director of research at the Pew Research Center and a lead author of the survey.

A narrow majority of respondents in the latest survey 55 percent said they thought vaccination had been somewhat or very effective at curbing the spread of the coronavirus. About half felt that way about wearing masks indoors. Respondents were more skeptical about the efficacy of people staying at least six feet apart indoors, with only 34 percent considering that practice at least somewhat effective.

The survey found very wide partisan gaps in attitudes toward all those preventive measures, especially mask-wearing, with Republicans far more likely than Democrats to say they did little or no good.

The poll included 10,282 adults who were surveyed online between May 2 and May 8.

$30 Million Funding Empowers All-in-One Vaccine Candidate to Tackle Future Coronaviruses – Precision Vaccinations

Posted on July 8, 2022 by Danzig

(Precision Vaccinations)

As of early July 2022, uncertainty persists as SARS-CoV-2 coronavirus mutations continue emerging. According to the World Health Organization, the Omicron BA.x variants are now dominant worldwide.

There is a clear need for strategies to tackle emerging variants and protect populations against potential future threats to human health, says vaccine researchers from the University of Oxford and Caltech.

A new consortium announced on June 5, 2022, aims to address these issues by establishing the first-in-human clinical proof of concept for a new vaccine design.

The consortium brings together researchers from the University of Oxford and Caltech to collaborate with deep tech innovation organization CPI and industrial biotechnology company Ingenza Ltd (Caltech-CPI-Oxford-Ingenza).

The Coalition for Epidemic Preparedness Innovations (CEPI) will partner with the consortium and has announced up to US $30 million to fund pre-clinical studies, GMP manufacturing, and Phase 1 trial based on this technology.

The vaccine will target both SARS-CoV-2 and several related bat viruses which have the potential to spread to humans. It builds on technologies developed by the Molecular Immunology Group at the University of Oxford and by the Bjorkman Group based at Caltech led by Professor Alain Townsend at the MRC Human Immunology Unit and Professor Pamela Bjorkman, respectively.

In contrast to many existing vaccine designs that use mRNA or a viral vector to present sections of the spike protein of a single type of virus to the immune system, this new vaccine will use protein nanoparticles containing a protein glue to attach related antigenic sections of the spike proteins from eight different viruses. By incorporating a mosaic-8 vaccine design created at Caltech, these nanoparticles would favor immune responses to the shared parts of each type of coronaviruses within a single vaccine.

Evidence published today in Science by the researchers demonstrates that this vaccine technology elicits protective immune responses against SARS-like viruses but also against some coronaviruses not presented in the trial vaccine. This suggests that the technology could protect against future novel SARS-CoV-2 variants and as-yet-undiscovered coronaviruses with the potential to spill over from animal populations.

Alain Townsend, Oxford Lead of the consortium, Professor of Molecular Immunology at the MRC Weatherall Institute of Molecular Medicine, University of Oxford, said:

The evolution of this consortium is an example of collaborative science at its best. We had been deeply impressed by the power of the glue for sticking proteins together developed by Mark Howarth (Biochemistry Oxford) and derived from his beautiful basic science investigations of the Streptococcus pyogenes bacterium.'

Together, we used this technology to make a prototype nanoparticle SARS-CoV-2 vaccine that induced highly potent responses in preclinical studies.'

Through connections made by Ian Wilkinson (Absolute Antibody), we joined with colleagues at Ingenza and CPI who succeeded in making a fully functional version of the vaccine produced in microbes, thus reducing the cost of production. In addition, we have been collaborating with Prof. Pamela Bjorkman and the Caltech team, who had independently developed the brilliant concept of the mosaic version of the vaccine and are excited to continue working with this world-class consortium.

The consortium partners are committed to equitable access to the project's outputs.

Dr. Jack Tan, Project Manager (Oxford) of the consortium, Senior Postdoctoral Scientist at the MRC Weatherall Institute of Molecular Medicine, said:

We are delighted to work with CEPI to further this nanoparticle technology to produce efficacious, low-cost, infrastructure-independent vaccine that will be accessible to low- and middle-income countries.

Dr. Richard Hatchett, CEO of CEPI, commented in a press release issued on July 6, 2022, There have already been three serious coronavirus epidemics or pandemics in the 21st century and COVID-19 continues to have a devastating impact on the worlds health, society, and economy. Creating vaccines that could provide broad protection against emerging COVID-19 variants and future coronavirus threats would not only help mitigate the damaging effects of another COVID-19-like pandemic, but it could also help reduce the time taken and funding spent continually updating vaccine formulations.

Thats why we are delighted to partner with this CPI-led research consortium to build on Wellcome Leaps initial investment to further advance this pioneering mosaic nanoparticle vaccine technology that, if successful, could work towards consigning the threat posed by coronaviruses to the history books.

The consortium aims to commence a Phase 1 trial in 2024, led by the Oxford Vaccine Group.

PrecisionVaccinationspublishes fact-checked, research-based news curated for mobile readership.

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$30 Million Funding Empowers All-in-One Vaccine Candidate to Tackle Future Coronaviruses - Precision Vaccinations

Epic, Caris Life Sciences working together on molecular testing integration – Healthcare IT News

Posted on July 8, 2022 by Danzig

Caris Life Sciences announced this week that it will be broadening its partnership with Epic, integrating its molecular testing portfolio with Epic's Orders and Results Anywhere network.

WHY IT MATTERSCaris offers whole exome and whole transcriptome sequencing, and by applying AI modeling to its clinico-genomic database, it can help researchers gain better insights into the molecular complexity of disease.

The new project builds on the existing integration of Caris' Genomics Module within Epicand will expand capabilities by offering easier ordering and receipt of molecular profiling results directly in patients' electronic health records.

Officials say Caris' whole suite of molecular profile services for tissue and blood samples will be available within the Orders and Results Anywhere network.

ORA network integration, expected to be available later this year, will help drive data-driven decision-making for Epic customers which represent 60% of oncologists nationwide, the companies note. By putting ordering and results directly into the network, Caris says it aims to offer more streamlined access to structured genomic data within the Epic environment.

THE LARGER TRENDThis is just the most recent in a string of announcements involving Epic and precision medicine technology developers. In June, Myriad Genetics announced it was working to integrate its genetic testing services within Epic's EHR workflows offering providers genetic insights for more personalized care and giving patients easier access to test results within MyChart.

In April, Guardant Health, which develops precision oncology tools,announced its own collaboration with Epic to streamline clinicians' ability to order Guardant blood tests, liquid biopsies and more within the EHR.

And this past August, Foundation Medicine announced a deal with Epic toadd its genomic profiling and testing services to the EHR workflow.

In other Epic news, the vendor announced this past month that it would join the Trusted Exchange Framework and Common Agreement and apply to connect to TEFCA as an inaugural Qualified Health Information Network.

ON THE RECORD"Caris Life Sciences is committed to fulfilling our organizational promise of making personalized precision medicine accessible to as many physicians and patients as possible," David Spetzler, president and CEO of Caris, said in a statement. "Building on the success of our Epic Genomics Module integration, ORA will further enhance patient access to critical molecular results they need to fight, and hopefully beat, cancer."

Alan Hutchison, VP of population health at Epic, said, "We are excited for this enhanced partnership with Caris to further increase health access and care, and the opportunity to help deliver precision medicine to a greater number of communities."

Twitter:@MikeMiliardHITNEmail the writer:mike.miliard@himssmedia.comHealthcare IT News is a HIMSS publication.

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Epic, Caris Life Sciences working together on molecular testing integration - Healthcare IT News

One Health Approach Is Necessary to Address Rising Environmental Causes of Childhood Cancers – Newswise

Posted on July 8, 2022 by Danzig

Newswise A multi-disciplinary, One Health approach to cancer research is necessary to guide society in reduction of toxic substances, as well as regulation of chemical impacts on the environment and public health, according to an editorial published recently in Issue II of Annals of Research in Oncology.

This medical-scientific journal is published by Editor in Chief Professor Antonio Giordano, M.D., Ph.D., Director and Founder of Sbarro Institute for Cancer Research and Molecular Medicine, and the Sbarro Health Research Organization (SHRO), at Temple University. The editorial by Prof. Philip Landrigan, Director of the Global Public Health Programme, highlights the relationship between environmental issues and childhood cancer cases, which have been growing rapidly over the past 50 years.

Landrigan's editorial moves towards the new scientific paradigm known as One Health, by which is meant the indissoluble intertwining of three factors: human health, animal health and environmental health as interconnected and dependent on each other.

In particular, Landrigan emphasises the link between environment and cancer in paediatric subjects, underlining the lack of scientific models that consider the use of chemicals with undesirable effects on human health, which are not carefully studied, and the consequent increase in oncological cases in paediatrics. In fact, there is evidence that environmental exposure, in particular to manufactured chemicals, are a major cause of childhood cancer. The National Cancer Institute currently directs about 1% of its funding towards research into environmental causes of paediatric cancers.

Landrigan's hope is to identify new scientific models based on epidemiological and toxicological studies to address the rising incidence of childhood cancer, a major challenge for society and the cancer and public health communities.

Excerpt from:

One Health Approach Is Necessary to Address Rising Environmental Causes of Childhood Cancers - Newswise

Promising topline results for intralymphatic Diamyd in patients with LADA – PR Newswire

Posted on July 8, 2022 by Danzig

STOCKHOLM, July 7, 2022 /PRNewswire/ --The primary endpoints of safety and tolerability were met in the open-label investigator-initiated Phase II clinical trial GADinLADA, in which the diabetes vaccine Diamydwas administered directly into the lymph node of 14 patients aged 30 to 70 years with the autoimmune form of diabetes called LADA (Latent Autoimmune Diabetes in Adults). Analyses also showed a positive immunological response to the treatment and the clinical course appears promising with all individuals remaining insulin-independent 12 months after treatment.

"These results are very encouraging and the next step is together with collaborators and authorities evaluate the regulatory requirements to get the diabetes vaccine Diamyd approved as a disease-modifying therapy in individuals diagnosed with LADA", says Ulf Hannelius, CEO of Diamyd Medical.

All patients in the trial were followed for twelve months after their first injection. The topline results showed that the safety was good with no treatment-related severe adverse events. The treatment was well tolerated by the trial participants, all of whom completed the study with no drop-outs. The immunological analyses showed a similar response to the treatment as has been shown in previous trials in individuals with recent-onset type 1 diabetes, with a clear GAD-specific immune response evident in both circulating antibodies and cell-based reactions.

The clinical course appears positive with all 14 individuals remaining insulin-independent after 12 months of follow-up. The endogenous insulin production, measured as mixed-meal stimulated C-peptide, declined on average only 10% over 12 months.

"The GADinLADA trial has been successful, and treatment with three intralymphatic injections of Diamyd has been well received by the LADA patients," says PhD Ingrid K Hals, Sponsor's representative of the trial. "We will present the results from this trial at the upcoming international Europen Association for the Study of Diabetes (EASD) conference in Stockholm in September and we look forward to evaluating together with Diamyd Medical the next steps to make this important treatment available for individuals diagnosed with LADA."

Of the 14 LADA patients included in the trial, half carry the HLA haplotype DR3-DQ2 that is associated with a positive clinical response to Diamyd treatment in individuals recently diagnosed with type 1 diabetes. For the 7 individuals carrying HLA DR3-DQ2, endogenous insulin production (stimulated C-peptide) decreased on average by 8 % over the 12 month study period, while in the 7 individuals not carrying HLA DR3-DQ2, it declined by 13 %. GAD-stimulated cell proliferation showed a decrease in proliferation between 5 and 12 months for the HLA-DR3-DQ2 group while a comparable decrease was not observed for the group negative for HLA DR3-DQ2, reflecting the patterns seen in recent-onset type 1 diabetes.

The results will be presented at the upcoming EASD conference to be held in Stockholm on September 19-23, 2022. The accepted abstract is entitled "Early effects of treatment with intralymphatic administration of rhGAD65 in LADA appear similar to those observed in type 1 diabetes", and will be presented as an oral abstract on September 20, 2022, as part of the session "OP 10 Beta cells: protecting what is precious".

About the GADinLADA trialThe main aim of the trial was to evaluate the safety of three intralymphatic injections of Diamyd in patients with LADA (Latent Autoimmune Diabetes in Adults). The patients were recruited in Norway at the Norwegian University of Science and Technology (NTNU), Dept. of Clinical and Molecular Medicine, in Trondheim, in collaboration with St. Olavs Hospital, University Hospital in Trondheim, and in Sweden at the Center for Diabetes, Akademiskt specialistcentrum, an academic specialist unit run in collaboration between Stockholm County's healthcare area, Karolinska Institutet and Karolinska University Hospital. The patients included in the trial were between 30 and 70 years old, diagnosed with LADA within the last 18 months and were not yet on insulin therapy. The Sponsor of the trial has been the Norwegian University of Science and Technology with Ingrid K Hals, PhD, as Sponsor's representative. Diamyd Medical has contributed with study drugs, expertise and some financial support for immunological analyses and determination of HLA haplotypes.

About LADALatent Autoimmune Diabetes in Adults represents close to 10% of patients diagnosed with type 2 diabetes. LADA is characterized by an ongoing autoimmune destruction of the insulin-producing beta cells, a process similar to that of type 1 diabetes, but slower. Although research categorizes LADA as autoimmune diabetes, the disease is still in most cases treated according to the guidelines for type 2 diabetes. LADA patients are usually not insulin dependent at diagnosis, but for most patients, insulin therapy is required within a few years of diagnosis.

About Diamyd MedicalDiamyd Medical develops precision medicine therapies for Type 1 Diabetes. The diabetes vaccine Diamyd is an antigen-specific immunotherapy for the preservation of endogenous insulin production. Significant results have been shown in a large genetically predefined patient group in a large-scale meta-analysis as well as in the Company's European Phase IIb trial DIAGNODE-2, where the diabetes vaccine was administered directly into a lymph node in children and young adults with recently diagnosed type 1 diabetes. DIAGNODE-3, a confirmatory Phase III trial is on-going. A vaccine manufacturing facility is being set up in Ume for the manufacture of recombinant GAD65, the active ingredient in the therapeutic diabetes vaccine Diamyd. Diamyd Medical also develops the GABA-based investigational drug Remygen as a therapy for regeneration of endogenous insulin production and to improve hormonal response to hypoglycaemia. An investigator-initiated Remygen trial in individuals living with type 1 diabetes for more than five years is ongoing at Uppsala University Hospital. Diamyd Medical is one of the major shareholders in the stem cell company NextCell Pharma AB as well as in the artificial intelligence company MainlyAI AB.

Diamyd Medical's B-share is traded on Nasdaq First North Growth Market under the ticker DMYD B. FNCA Sweden AB is the Company's Certified Adviser; phone: +46 8-528 00 399, e-mail: [emailprotected]

For further information, please contact:Ulf Hannelius, President and CEOPhone: +46 736 35 42 41E-mail: [emailprotected]

This information was brought to you by Cision http://news.cision.com

https://news.cision.com/diamyd-medical-ab/r/promising-topline-results-for-intralymphatic-diamyd--in-patients-with-lada,c3598517

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Promising topline results for intralymphatic Diamyd in patients with LADA - PR Newswire

New Study shows Urolithin A (Mitopure) Improves Mitochondrial Health, Reduces Joint Cartilage Damage and Alleviates Pain in Osteoarthritis – Business…

Posted on July 8, 2022 by Danzig

Lausanne, Switzerland & San Francisco, United States:

New research by scientists at Amazentis and Scripps Research indicates Urolithin A shows promise for improving mobility with beneficial effects on structural damage in joints, published in Aging Cell

Tests in cells from healthy donors and from osteoarthritis (OA) human patients, and in the joints of OA mice, show improvements associated with increased mitochondrial health

Amazentis, a spin-off of the Swiss Federal Institute of Technology (EPFL) pioneering scientific breakthroughs in cellular health and nutrition, announced today that the peer-reviewed journal Aging Cell published new pre-clinical results showing the joint health benefits of gut microbiome postbiotic Urolithin A (UA). This is the first time a compound has been shown to improve mitochondrial health in an experimental model of osteoarthritis (OA).

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220707005266/en/

(Photo: Amazentis)

This study showed that treatment with Amazentis proprietary Urolithin A, Mitopure, significantly improved mitochondrial health in human cartilage cells taken from both healthy and OA knee joints. And it showed that supplementation with Mitopure for eight weeks protected against osteoarthritis disease progression in an experimental model.

These findings highlight Mitopures benefits for joint and mitochondrial health. Mitopure works by supporting the cells ability to renew their powerplants, the mitochondria, during the aging process. This change is associated with age-related problems in various tissues, including osteoarthritis.

Previous research has shown Mitopure can improve mitochondrial health and muscle function in both older and middle-aged human populations. This new paper extends these benefits to cells in key joints such as the knee. Osteoarthritis is the most common age-related joint disorder, characterized by degradation of cartilage and other tissues, severe pain, and impaired mobility.

There are currently no effective solutions to treat osteoarthritis, a condition that is painful and limits the mobility of hundreds of millions of older people around the world. We tested Urolithin A in preclinical models of osteoarthritis and showed it has potential to both reduce inflammation and improve mitochondrial health, suggesting it may be a promising solution to support joint health and quality of life during aging, says Martin Lotz MD, lead author on the paper and Professor of Molecular Medicine at Scripps Research in California, USA.

This study is important and exciting as it shows, for the first time, that Urolithin A can increase mitochondrial health in living joint tissue, says Davide DAmico, first author on the paper and R&D Group Leader with Amazentis. It highlights the important role of mitophagy in maintaining healthy functioning joints throughout life.

In this study, Mitopure showed two key beneficial effects on cartilage cells from both healthy donors and OA patients:

The second part of the study focused on the effect of supplementing Mitopure for 2 months on an experimental pre-clinical model of osteoarthritis. This model mimics the same symptoms experienced by people suffering from osteoarthritis, i.e. progressive cartilage damage, increased pain and inflammation.

"It was great to collaborate with Scripps Research to expand the body of evidence on the health applications of Urolithin A into joint health. Its exciting to see a compound and mechanism of action that is benefiting both muscle and joints. We remain committed to delivering products that are clinically proven to have a meaningful impact on peoples health says Chris Rinsch, CEO and co-founder of Amazentis.

The new results are significant because they add to growing evidence of the benefits of Mitopure on age-related conditions. Recent studies showed that Mitopure can improve mitochondrial health and counteract age-related muscle function decline in both healthy elderly and middle-aged overweight subjects. Together, the latest research supports a combined beneficial action of Urolithin A in both muscle and joints.

Doi: 10.1111/acel.13662

About Amazentis Amazentis is an innovative life sciences company employing todays leading research and clinical science to develop the next generation of products targeting mitochondrial health for advanced nutrition. Amazentis has previously published its research on Mitopure Urolithin A in top peer reviewed scientific journals including Nature Medicine (doi:10.1038/nm.4132), Nature Metabolism (doi: 10.1038/s42255-019-0073-4), JAMA Network Open (doi:10.1001/jamanetworkopen.2021.44279), Cell Reports Medicine(Doi: 10.1016/j.xcrm.2022.100633) and European Journal of Clinical Nutrition (https://doi.org/10.1038/s41430-021-00950-1). The company has a global strategic partnership with Nestl Health Science to expand the health applications of Mitopure linked to mitochondrial and cellular health. For more information on Amazentis, please visit http://www.amazentis.com.

About Mitopure Mitopure is a highly pure form of Urolithin A; a bioactive dietary metabolite that is produced by gut bacteria after eating certain foods, such as the pomegranate, though it is difficult for most people to get enough of this specialized nutrient from food alone. Mitopure has been shown to improve mitochondrial function by stimulating mitophagy, a process by which aging and damaged mitochondria are cleared from the cell, making way for healthy mitochondria to grow. Mitopure has been favorably reviewed by the U.S. Food and Drug Administration (FDA) and deemed safe following a GRAS (generally recognized as safe) filing. Mitopure has been extensively evaluated pre-clinically and clinically to support its use in humans for nutritional supplementation. For more information, please visit http://www.mitopure.com.

About Timeline Timeline is brought to you by the inventors of Mitopure. This novel, science-first nutrition brand was developed by Amazentis on the belief that uncompromising research can unlock a new class of clinically validated nutritional products to optimize cellular health. For more information, please visit http://www.timelinenutrition.com.

The NRC HL Holmes Award supports the development of technology to target and treat basal-like breast cancer – National Research Council Canada -…

Posted on July 8, 2022 by Danzig

The 2021 H.L. Holmes Award was presented to Dr. Khalid Al-Zahrani for his novel advancements in breast cancer research. In developing a never-before-seen method, he is able to screen for specific cancer driving genes and has validated his research with promising results.

Over two years, the $180,000 award will support Dr. Al-Zahrani in the development of a gene system to identify the cause of basal-like breast cancer (BLBC). As BLBC disproportionally affects younger, premenopausal women and has a relatively poor clinical prognosis, his research will expand our knowledge of this aggressive cancer subtype which could greatly improve existing treatment methods.

Dr. Al-Zahrani will continue to work with Mount Sinai's Lunenfeld-Tanenbaum Research Institute in Toronto where he has been a post-doctoral research fellow since 2019 in Dr. Daniel Schramek's group, a world-renowned expert in genetic models of cancer. Dr. Al-Zahrani completed his Ph.D. (Philosophy, Cellular and Molecular Medicine) and B.Sc. (Specialization in Biochemistry) at the University of Ottawa and has published over a dozen articles in scientific and medical journals. As a Canadian with roots in Scotland and Saudi Arabia, Dr. Al-Zahrani is excited to develop new medicine that will help people worldwide.

Already, Dr. Al-Zahrani is exploring the uncharted field of BLBC copy number alterations with the development of a novel in vivo CRISPR technology. BLBC copy number alterations are parts of the DNA that are gained or lost that cause tumors to develop from normal cells, and in vivo refers to experiments in whole, living organisms. Using the CRISPR system, researchers can edit genes by activating or deactivating specific parts of genetic code, which allows for precise manipulation of DNA. Dr. Al-Zahrani is a pioneer in the field of BLBC genetics as he aims to understand the underlying mechanisms that drive cancer cells. His findings may uncover new approaches in the way we provide treatment.

Over two years, Dr. Al-Zahrani generated 14 different gene targeting systems in hopes of finding an all-in-one solution to target and screen specific cancer cells. He developed a technology termed KOALA (Knock-Out and Activation Linked Assay) which, when paired with CRISPR, can pick out certain parts of genetic code and trigger precise activation or deactivation. Overcoming numerous roadblocks, he finally achieved a system sufficient for use in mouse specimens. His method will allow for screening of specific BLBC genes and may ultimately identify parts of genetic code that trigger tumor growth. Importantly, KOALA allows for the rapid screening of thousands of cancer-causing genes in a single experiment, whereas conventional techniques screen a single potential cancer-causing gene at a time. The efficiency of his system is validated by discovering several new potential targets for treating BLBC. This is a pivotal step in understanding breast cancer as it greatly improves upon existing methodologies by saving both time and money in the identification of important cancer-driving genes. In combination with conventional tumor-suppressing gene therapy, identification of specific cancer-causing genes allows for highly targeted therapeutic approaches.

While mouse models are suitable for initial experiments, Dr. Al-Zahrani will carefully evaluate further findings in human patient samples. His innovative progress has the potential to uncover new effective cancer treatments and improve the clinical prognosis of basal-like breast cancer.

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The NRC HL Holmes Award supports the development of technology to target and treat basal-like breast cancer - National Research Council Canada -...

Sri Lanka : WHO provides technical support to the study on investigating seroprevalence of SARS-CoV-2 and dengue infections in Sri Lankan children -…

Posted on July 8, 2022 by Danzig

* WHO provides technical support to the study on investigating seroprevalence of SARS-CoV-2 and dengue infections in Sri Lankan childrenFri, Jul 8, 2022, 12:23 pm SL Time, ColomboPage News Desk, Sri Lanka.

July 08, Colombo: Sri Lanka too experienced a rapid rise in number of cases and deaths, with the community spread of the Delta variant of the SARS-CoV -2 virus. However, deaths were predominantly seen among adults, with children rarely developing severe disease, as observed in other countries.

Sri Lanka experienced two massive COVID-19 outbreaks due to the Alpha and Delta variants of the SARS-CoV -2 virus, resulting in a large number of individuals being infected in the community. It was estimated that surveillance of SARS-CoV-2 with the Real-time polymerase chain reaction (RT-PCR) testing alone may underestimate the true prevalence of the disease by tenfold. Therefore, conducting a seroprevalence study remained an option for Sri Lanka to determine prevalence of SARS CoV-2 specific antibodies due to infection or vaccines in the country.

Seroprevalence studies help understand the true extent of an outbreak and provide valuable insights in to efforts that help project the trend of future outbreaks, and their transmission dynamics. However, in Sri Lanka, a majority of infections was reported in adults, most of whom experienced more severe and symptomatic infections. On the other hand, true infection rates among children in the country were not clearly known. One of the reasons for this could be limited PCR testing in children, largely because they do not show symptoms following infection with SARS-CoV-2 virus. Also, infection rates could be very different across districts, based on the intensity of transmission reported in different geographical regions.

Considering the above, the Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura and the Ministry of Health supported by WHO Country Office for Sri Lanka planned a study on seroprevalence of SARS-CoV-2 infections and dengue infections in Sri Lankan children.

In order to submit the study protocol to WHOs Ethical Review Committee, a joint review of study protocols was undertaken by the Unity trial desk of WHO Headquarters, the SEA Regional Office and the WHO country office for Sri Lanka. After revising the study protocol based on WHO recommendations, investigators submitted the finalized protocol to the Regional Review Committee.

The proposed study will help Sri Lanka determine the proportion of children who have been infected with COVID-19 and also with dengue, by studying the presence of antibodies to these viruses in children of different age groups. Additionally, it will determine genetic associations that predispose children to severe disease of dengue. Further, the study will provide information that will help understand how COVID-19 and dengue have spread geographically in the Sri Lankan population.

The seroprevalence in this study will be determined by biological assays, which are both qualitative and quantitative (ELISA, Luminex). The patient data will be collected on clinical features, clinical disease severity and complications.

The findings of this investigation will be used to inform public health response to COVID-19. Specifically, it can provide estimates of otherwise unrecognized SARS-CoV-2 infection in the population, as well as likely susceptibility of the population to further epidemic peaks. The findings may also supplement other supportive evidence used to inform decision-making about vaccine prioritization for target groups, based on demonstrated susceptibility by age groups.

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Sri Lanka : WHO provides technical support to the study on investigating seroprevalence of SARS-CoV-2 and dengue infections in Sri Lankan children -...

Dry Eye Disease Market: Increasing Awareness and the Booming Geriatric Population to Accelerate the Market Growth – BioSpace

Posted on July 8, 2022 by Danzig

Wilmington, Delaware, United States, Transparency Market Research Inc.: Eye-related disorders are expanding at an accelerated pace across the globe. One of the most common disorders of the eyes is dry eye disease. The growing geriatric population and the increasing screen time among individuals have resulted in the rising cases of dry eye diseases. According to numerous studies, the incidence of dry eye diseases is between the ranges of 8 percent to 34 percent. Hence, these factors have influenced the growth structure of the dry eye disease market considerably and will continue to influence during the forecast period of 2017-2025.

When an individual suffers from dry eye disease, his/her eyes do not produce enough tears. Dry eye also occurs when one is not able to maintain a normal layer of tears for coating the eyes. The common symptoms of dry eye disease are redness, stringy mucus, blurry vision, pain, difficulty reading, or not able to sit before the computer for long hours, etc. Dry eye disease is of two types: aqueous deficiency dry eye disease and evaporative dry eye disease.

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The prominent risk factors for eye diseases are diabetes, refractive surgeries, aging, consumption of certain medications, etc. Anti-inflammatory drugs, cyclosporine, artificial tears, lifitegrast, secretagogue, punctal plugs, and others are some vital treatment types for eye diseases.

The players indulge in research and development activities for expanding the growth landscape of the dry eye disease market. The players invest in these activities to find new treatments for dry eye diseases. These activities help in strengthening the revenue cycle of the global market, eventually increasing the growth rate. Mergers, acquisitions, joint ventures, and partnerships also form an important part of the dry eye disease market growth structure. These collaborations assure expansion of the treatment types in other regions and significantly impact the growth trajectory.

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According to the TMR experts, the market for dry eye disease is prognosticated to expand at 4.5 percent CAGR during the forecast period of 2017-2025. In the context of valuation, the plasma protein therapeutics market is estimated to reach a valuation of US$ 7,780 mn by 2025 and was valued at US$ 5045.2 mn in 2016.

Anti-Inflammatory Drugs to Reign Supreme in Terms of Demand

The use of anti-inflammatory drugs for treating dry eye diseases has increased exponentially over the years. Research activities revolving around anti-inflammatory drugs are increasing extensively, ultimately leading to an increase in the development of new drugs. These factors will influence the growth of the dry eye disease market to a considerable extent. The anti-inflammatory drugs segment is expected to dominate in terms of revenue and demand, whereas the artificial tears segment may emerge as the second-largest growth-contributing segment.

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Growing Awareness about Various Treatment Types to Increase Growth Prospects Considerably

Government and non-government initiatives are encouraging many individuals to diagnose and get treated for dry eye diseases. This factor will have a great impact on the growth of the dry eye disease market. Further, many companies in the dry eye disease market promote their products through effective strategies, ultimately contributing to the growth trajectory.

Accelerated FDA Approvals to Boost Growth of North Americas Dry Eye Disease Market

The approvals for new dry eye disease treatment drugs at a rapid pace will bring immense growth prospects for the dry eye disease market in North America. The Food and Drug Administration (FDA) is trying to speed up the approval process to provide good and effective dry eye disease treatment options to the citizens. Hence, this factor will help North Americas dry eye disease market to gain a larger growth share.

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Some well-entrenched players in the dry eye disease market are Sun Pharmaceutical Industries Ltd., Valeant Pharmaceuticals International, Inc., Otsuka Pharmaceutical Co., Ltd., TRB Chemedica International SA, Novartis AG, Johnson & Johnson, and Sentiss Pharma Pvt. Ltd.

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First Edition: July 8, 2022 – Kaiser Health News

Posted on July 8, 2022 by Danzig

Today's early morning highlights from the major news organizations.

KHN:Digital Mental Health Companies Draw Scrutiny And Growing ConcernsWhen Pat Paulsons son told her he was feeling anxious and depressed at college, Paulson went through her Blue Cross Blue Shield provider directory and started calling mental health therapists. No providers in the Wisconsin city where her sons university is located had openings. So she bought a monthly subscription to BetterHelp, a Mountain View, California, company that links people to therapists online. (Meyer, 7/8)

KHN:The Push For Abortion Lawmaking After Dobbs Is Unique, Legal And Political Experts SayThe end of nationwide abortion protections has been met with a wave of calls from lawmakers and governors in at least a dozen states for special legislative sessions that would reshape the state-by-state patchwork of laws that now govern abortion in the U.S. I havent seen so many states focusing their attention so quickly on one issue, said Thad Kousser, a professor who studies state politics. (Zionts, 7/8)

KHN:Vaccine And Testing Delays For Monkeypox Echo Failures In Early Covid ResponseAndy Stone is one of the lucky ones. The New York City resident saw a tweet from a local AIDS activist saying that monkeypox vaccines would be available that day at a clinic in Manhattan. Stone, 35, and his husband booked appointments online right away and got their shots last month. I want to do what I can to protect myself and others, said Stone, a marketing consultant living in Brooklyn, who said his primary care doctor advised him to get the vaccine as soon as possible. (Andrews, 7/8)

KHN:The Search For Scarce Formula Is Worse For Rural Families On WICTwo months after giving birth, Jennifer Magee noticed a change in her babys feeding routine that scared her: She was starting to drink more formula, almost every hour. Increased appetite is normal for growing infants, including Magees daughter, Aubrey. But amid the national formula shortage, Magee, 25, had only one container left, barely enough to last three days. (Saint Louis, 7/8)

KHN:KHNs What The Health?: A Chat With The Surgeon General On Health Worker BurnoutThe pandemic has taken a toll on everyone, but those who work in health care have suffered disproportionately, according to a new report from the office of U.S. Surgeon General Vivek Murthy. And its not just the workers who are at risk. If not addressed, the health worker burnout crisis will make it harder for patients to get care when they need it, cause health costs to rise, hinder our ability to prepare for the next public health emergency, and worsen health disparities, according to the report. (7/7)

AP:Dems Want To Tax High Earners To Protect Medicare SolvencySenate Democrats want to boost taxes on some high earners and use the money to extend the solvency of Medicare, the latest step in the partys election-year attempt to craft a scaled-back version of the economic package that collapsed last year, Democratic aides told The Associated Press. Democrats expect to submit legislative language on their Medicare plan to the Senates parliamentarian in the next few days, the aides said. (Fram, 7/7)

The New York Times:Democrats Propose Raising Taxes On Some High Earners To Bolster MedicareThe proposal is projected to raise $203 billion over a decade by imposing an additional 3.8 percent tax on income earned from owning a piece of what is known as a pass-through business, such as a law firm or medical practice. The money that would be generated by the change is estimated to be enough to extend the solvency of the Medicare trust fund that pays for hospital care currently set to begin running out of money in 2028 until 2031. (Cochrane, Sanger-Katz and Tankersley, 7/7)

Politico:Dems' Climate And Tax Agenda To Consume Congress In JulyNegotiators are still ironing out key details, but Democrats are signaling that as soon as next week they will begin arguing their case to the Senate rules chief on why the package should pass with a simple majority in the chamber. No one is getting their hopes too high in a party still reeling from Manchins rejection of Build Back Better, Democrats previous version of the legislation. (Everett and Levine, 7/7)

The Hill:Newsom Announces California Will Produce Its Own Low Cost InsulinCalifornia Gov. Gavin Newsom (D) announced on Thursday that his state will be producing its own low cost insulin, stating, People should not go into debt to get lifesaving medication. Newsom said that the state budget he recently signed includes $100 million for California to contract and make [its] own insulin at a cheaper price, close to at cost, and to make it available to all. (Breslin, 7/7)

The Hill:GOP Senators Call For Hearings On Bipartisan Insulin Cost BillFive GOP senators are calling on the Senate Finance Committee to hold hearings on bipartisan legislation to lower the cost of insulin. Led by Sens. Pat Toomey (Pa.), and John Barrasso (Wyo.), the Republicans said they were concerned the legislation from Sens. Susan Collins (R-Maine) and Jeanne Shaheen (D-N.H.) will be brought to the Senate floor for a vote without going through the committee first. (Weixel, 7/7)

AP:Facing Pressure, Biden To Sign Order On Abortion AccessPresident Joe Biden will take executive action Friday to protect access to abortion, according to three people familiar with the matter, as he faces mounting pressure from Democrats to be more forceful on the subject after the Supreme Court ended a constitutional right to the procedure two weeks ago. Biden will speak Friday morning on protecting access to reproductive health care services, the sources said. The actions he was expected to outline are intended to try to mitigate some potential penalties women seeking abortion may face after the ruling, but are limited in their ability to safeguard access to abortion nationwide. (Kim and Miller, 7/8)

The Hill:Feinstein Says Shed Vote For Filibuster Carve-Out To Codify Abortion RightsSen. Dianne Feinstein (D-Calif.) on Thursday said she supports the Senate removing the procedural filibuster rule in order to codify abortion rights into law. Feinstein said she certainly would vote to support a carve-out to the filibuster to pass the Womens Health Protection Act and codify federal-level abortion protections. (Dress, 7/7)

AP:Lone Mississippi Abortion Clinic Seeks Legal Path To ReopenAttorneys for Mississippis only abortion clinic filed papers Thursday asking the state Supreme Court to block a new law that bans most abortions and to let the clinic reopen next week. The clinic, Jackson Womens Health Organization, is at the center of the recent U.S. Supreme Court ruling that overturned Roe v. Wade and took away womens constitutional protection for abortion nationwide. (Pettus and Kolpack, 7/7)

Axios:North Dakota's Only Abortion Clinic Sues State Over Trigger BanRed River Womens Clinic, the only remaining abortion provider in North Dakota, is suing state officials over the state's trigger ban, which is set to take effect later this summer. (Gonzalez, 7/7)

AP:Indiana's Abortion Laws May Tighten Before Legislature ActsIndianas abortion laws will likely be tightened even before the Legislature is expected to start debating additional abortion restrictions later this month. Lawyers for the American Civil Liberties Union of Indiana conceded defeat Friday in their fight to block two anti-abortion laws following the U.S. Supreme Courts decision last month to end constitutional protection for abortion. That led the state attorney generals office on Wednesday to ask U.S. District Judge Sarah Evans Barker in Indianapolis to sign off on orders that would lift her injunctions that have prevented enforcement of those laws. (Davies, 7/7)

The New York Times:After Roe, South Carolina Considers More Restrictions On AbortionWith anti-abortion Republicans in firm control of South Carolinas legislature and executive branch, a new proposal offering something closer to an outright ban seems quite likely, although the details have yet to be hammered out. On Thursday, the exploration of a new abortion law began with a meeting of a 14-member, Republican-dominated House committee. But a bill introduced in the House has been left intentionally vague, with just a few lines of text including a statement that state law would be changed so as to prohibit abortions in the state of South Carolina. (Fausset and Sasani, 7/7)

AP:Senate GOP Advances Constitutional Amendment On AbortionRepublican state senators outvoted impassioned Democratic opposition late Thursday to advance a proposal to add language to the Pennsylvania Constitution stating explicitly that the document does not guarantee any rights relating to abortion or public funding of abortions. (Scolforo, 7/7)

USA Today:'DIY Abortion' On TikTok: Experts Urge Americans To Avoid These HerbsThe changing landscape of abortion access across the country has prompted many Americans to turn to the internet for answers, including how to self-manage an unwanted pregnancy at home. Google searches for DIYabortion have skyrocketed since the Supreme Courts decision in June overturning Roe v. Wade, the nearly 50-year landmark ruling that legalized abortion nationwide. (Rodriguez, 7/7)

NBC News:U.S. To Ship 144,000 More Monkeypox Shots And Expand Testing As Cases Top 700The Department of Health and Human Services announced Thursday that it will distribute 144,000 doses of the two-shot Jynneos vaccine, which is approved for monkeypox and smallpox, to cities and states starting Monday. That's on top of 56,000 doses the department made available last week, of which 41,000 have been delivered. (Bendix, 7/8)

CIDRAP:US Monkeypox Cases Top 600 In 34 StatesThe monkeypox virus outbreak is growing in the United States and elsewhere, with the US Centers for Disease Control and Prevention (CDC) now reporting 605 cases in 34 states, the District of Columbia, and Puerto Rico. New York has the most cases, with 122, followed by California with 116 and Florida with 64. (Soucheray, 7/7)

AP:Louisiana Identifies 1st Known Monkeypox Case In A ResidentLouisianas first detected cases of monkeypox have been found in a state resident and a visitor from out of state, the Louisiana Department of Health reported Thursday. There are likely more undiagnosed human cases of monkeypox existing in Louisiana than have been formally tested and identified to date, a news release said. (7/7)

AP:6 Monkeypox Cases Confirmed In OregonHealth officials in Oregon said Thursday they have confirmed six cases of monkeypox in the state. The cases all affecting men include one in Multnomah County; three in Lane County; and two in Washington County, the Oregon Health Authority said in a statement. There have been no deaths. (7/7)

The Boston Globe:10 More Monkeypox Cases Diagnosed In Massachusetts As State Initiates Vaccination ProgramTen more men in Massachusetts have been diagnosed with monkeypox in the past week, bringing the number of cases in the state to 31 since the first infection was announced on May 18, health officials said Thursday, as the state rolled out a vaccination program for those at highest risk. (Fox, 7/7)

The Baltimore Sun:A Baltimore Resident With A Case Of Monkeypox Makes The Case For An Urgent Public Health ResponseAs his trip to Europe in mid-June was winding down, Justin, a 48-year-old Baltimore man, developed a fever and sore throat. His lymph nodes swelled. When I started seeing dots on my body I thought, oh, boy, this isnt anything Ive experienced before, he said. (Cohn, 7/7)

Newsweek:Abe Shinzo Shot Despite Japan Having Incredibly Strict Gun LawsIn 1958, it was written into Japanese law that "no person shall possess a firearm or firearms or a sword or swords,"the opposite of the U.S. Second Amendment's affirmation of the "right of the people to keep and bear arms." Handguns are forbidden, while small-caliber rifles have been illegal to buy, sell or transfer since 1971. The only guns that Japanese citizens can legally buy and use are shotguns and air rifles. To do so involves negotiating a head spinning amount of red tape, requiring attendance at an all-day class, passing a written test and getting at least 95 percent accuracy during a shooting-range test. (Cole, 7/8)

The Washington Post:With Little Outcry, Chicagos Bloody Weekend Eclipsed Highland Park TollNo new counseling resources were announced this week on this citys impoverished South Side, even after a man was shot to death in broad daylight, feet from a playground, days before July Fourth. There are no crowdsourced charity drives raising millions for victims families in Chicago, where the holiday weekend death toll reached at least 10 with 62 injured numbers that exceed the toll from a July Fourth parade shooting in nearby Highland Park, Ill. In that affluent lakeside suburb, the violence was an anomaly. Here, it is a grimly regular occurrence. (Klemko, 7/7)

ABC News:NYPD Says Murders And Shootings Are Down, Despite Recent High-Profile IncidentsThe New York City Police Department said Thursday that murders and shootings are down in the city, despite three people being killed within an hour the night before. In June, murders were down 12% compared to the same period last year and shootings decreased by 13% last month compared to June 2021, the department said. (Grant and Katersky, 7/7)

ABC News:About 300,000 Kids Under 5 Have Gotten At Least 1 Dose Of COVID Vaccine So FarBy the end of Thursday, roughly 300,000 children under the age of 5 years old will have received at least one dose of a COVID-19 vaccine, a senior Biden administration official told ABC News. The 300,000 shots in arms so far for kids under 5 is about 1.5% of the roughly 19.5 million U.S. children 4 years old and younger. (Pezenik, 7/7)

AP:Slow Pace For Youngest Kids Getting COVID Vaccine DosesU.S. officials had long predicted that the pace of vaccinating the youngest kids would be slower than for older groups. They expect most shots to take place at pediatricians offices. ... More than 5 million pediatric doses have been shipped to more than 15,000 locations, the White House said, ready for parents and kids to come in. (Miller and Johnson, 7/7)

The New York Times:What The BA.5 Subvariant Could Mean For The United StatesThe most transmissible variant yet of the coronavirus is threatening a fresh wave of infections in the United States, even among those who have recovered from the virus fairly recently. ... I think theres an underappreciation of what its going to do to the country, and it already is exerting its effect, said Eric Topol, a professor of molecular medicine at Scripps Research, who has written about the subvariant. (Leatherby, 7/7)

San Francisco Chronicle:Whats The Risk Of Getting COVID Outside? Heres Why New Variants May Have Changed The AnswerHealth experts agree that outdoor activities are still much safer than indoors, since viral aerosols dont have a chance to accumulate in the air. But with the most transmissible variants yet, chances are you have less protection in certain situations. Being at parks and outdoor sporting events is still what we should turn to, said Dr. Anne Liu, an infectious disease doctor at Stanford. But if you are in a dense crowd or in an outdoor space that has been modified to look like an indoor space, then the risk becomes higher. (Vaziri, 7/7)

Houston Chronicle:Harris County Surpasses 1 Million COVID Cases Under Worst Surge YetHarris County this week officially surpassed one millionconfirmed COVID-19 cases,according to state health department data, but medical experts saythe true number is likely much higher. The continuing surge of infections has been attributed to BA.5, the newest sub-variant. BA.5 accounts for 53.6% of new cases, making it the dominant COVID strain in the U.S., according to the Centers for Disease Control. (Dozier, 7/7)

AP:COVID-19 Cases Prompt Mask Mandate At Denali National ParkMasks will be required for people using federal buildings or riding buses inside Denali National Park and Preserve because of high COVID-19 levels in the broader community, officials said Thursday. The mask mandate takes effect Friday, a statement from the park said. (7/7)

Los Angeles Times:Physicians Caution Against Working Through COVID-19Physicians caution, however, that rest is an important part of weathering a COVID-19 infection. Plugging away from home is better than putting others at risk of getting infected, but it can still strain the immune system, worsening the toll of a COVID infection, experts say. (Alpert Reyes, 7/7)

The New York Times:The Pandemic Has Eroded Americans Trust In Experts And Elected Leaders Alike, A Survey FindsAs the coronavirus pandemic entered its third year, the American public had lost much of its trust both in public health experts and in government leaders, and was less worried than before about Covid-19, according to a survey conducted in early May and released Thursday by the Pew Research Center. (Chung and Olson, 7/8)

The Atlantic:How Are We Possibly Still Disinfecting Things?Although most people are no longer disinfecting their groceries, signs flaunting cleanliness are still all over the place. Public bathrooms tout regular spray-downs with disinfectant. Elevators advertise self-cleaning buttons. At my local Marshalls, the cashier sanitizes the credit-card reader after every useeven if I use Apple Pay! A recent issue of United Airlines in-flight magazine was treated with an antimicrobial process, according to its cover. Signs lining the queue for a Delta flight in June read, cryptically: certified by lysol pro solutions. (Tayag, 7/7)

The Wall Street Journal:Theranoss Ramesh Sunny Balwani Found Guilty On All 12 Fraud CountsA federal jury convicted Ramesh Sunny Balwani, the former top lieutenant to Theranos Inc. founder Elizabeth Holmes, on all 12 charges that he helped perpetuate a yearslong fraud scheme at the blood-testing startup. The verdict is the second conviction against Theranos leadership and comes six months after a jury found Ms. Holmes guilty of fraud; it secures another major victory for the U.S. government, which brought the case against the pair in 2018. (Somerville and Bobrowsky, 7/7)

Stat:Drug Companies Will Have To Start Refunding Medicare For Certain DrugsStarting next year,pharmaceutical companies will have to repay Medicare for any unused amount of drugs that come in single-dose vials. On Thursday Medicare implemented this new provision as part of its broader annual rule that updates physician payments for 2023. (Herman, 7/7)

AP:Whistleblower Physician Reinstated At California VA HospitalA whistleblower physician who was forced into retirement after raising concerns about anesthesia staffing practices during surgeries at a Los Angeles Veterans Affairs hospital has gotten his old job back, federal officials said Thursday. (7/7)

AP:Northern West Virginia Hospital Settles With Feds For $1.5MA hospital in West Virginias Northern Panhandle has agreed to pay $1.5 million to the federal government to settle allegations that the medical center provided financial incentives to physicians for referring Medicare patients there, U.S. Justice Department officials said Thursday. (7/7)

Health News Florida:A Florida Medical Malpractice Case Is Under The Microscope Of Hospital And Doctor GroupsState and national groups representing hospitals and doctors are trying to help sway the Florida Supreme Court in a dispute about whether a medical malpractice lawsuit should have been allowed to move forward. (Saunders, 7/7)

AP:NC Governor Signs Bills Addressing Sexual Assaults, AlcoholNorth Carolina Gov. Roy Cooper signed 11 bills on his desk into law Thursday, including legislation that addresses sexual assault, domestic violence and alcohol sales. ... One signed measure makes clear that hospitals or medical offices cant attempt to bill victims of sexual assault or their insurance companies for forensic medical examinations, leaving it to a special state fund thats already been in place to cover the payment. (Robertson, 7/7)

AP:Fentanyl-Driven Overdoses Jump, Officials Urge NaloxoneAn Oregon Health Authority analysis released Thursday has found that drug overdose deaths in Oregon more than doubled between 2019 and 2021, driven largely by misuse of the powerful synthetic opioid fentanyl. (7/8)

CIDRAP:CDC Reports 12 More Unexplained Hepatitis Cases In Kids, 332 TotalIn a weekly update, the US Centers for Disease Control and Prevention (CDC) yesterday reported 12 more unexplained pediatric hepatitis cases in children, raising the national total to 332. The number of affected states held steady, at 42. (7/7)

The Boston Globe:Four Young Adults Sickened After Cohasset Swim Center Opens Prematurely, Town SaysFour young adults participating in a swim practice were sickened at the Cohasset Swim Center on Wednesday after the facility opened prematurely and a broken pipe caused a leak in its largest pool, town officials said. The center, which is not owned or operated by the town, opened to the public without its finalized building permit or pool health inspection permit, according to a statement Thursday from the office of Cohasset Town Manager Christopher G. Senior. (Fox, 7/7)

WUSF Public Media:Contaminated Oysters Found As Far North As Tampa Bay Could Pose Health RisksWith a new state law addressing the clean-up of chemical compounds that have been widely used by industries, a Florida International University study says the substances have been found in oysters in Biscayne Bay, the Marco Island area and Tampa Bay. (7/7)

Albany Herald:CIT Bracelets Help Ease Encounters Between Police, Mental Health SufferersAs a fashion statement theyre not much. But these rubber bracelets could make a big difference with police officers interacting with individuals suffering from mental illness and alter the results of an encounter from a trip to jail to referral to treatment. ... The bracelets, which say CIT (Critical Intervention Training) on one side and Mental Health Alert on the other, can let police know how to better handle a situation when they encounter someone who is wearing one. (Mauldin, 7/6)

Axios:Race May Factor Into Leukemia Survival, Study SuggestsYounger Black leukemia patients were likelier to die early or not go into complete remission than their white peers when receiving the same intensive treatment, according to a new study in Blood Advances. (Dreher, 7/7)

NPR:Scientists Look To People With Down Syndrome To Test Alzheimer's DrugsPeople with Down syndrome are highly sought after for Alzheimer's research studies because many develop the disease in their 40s and 50s, and most will get it if they live long enough. The elevated risk for Alzheimer's comes from the extra copy of chromosome 21 carried by people with Down syndrome. (Hamilton, 7/7)

NPR:HIV Patients Who Get Leishmaniasis Face A Tough Road. But Now There's New Hope"If you don't get the treatment, you're usually going to die from this," says Dr. Fabiana Alves, director of the leishmaniasis cluster at the Drugs for Neglected Diseases Initiative. VL is even more devastating for a patient whose immune system has been compromised by HIV, simply because the existing VL treatments don't work as well. And in parts of the world where VL is rampant, like eastern Africa and Southeast Asia, a significant percentage of patients are HIV positive. (Barnhart, 7/7)

USA Today:Is 'Hangry' Real? New Study Says You Do Get Angry When HungryIf you are someone whogets angry if youhaven't eaten, also known as "hangry," a new study says you aren't being irrational.The findings, published in the peer-reviewed journalPlos One on Wednesday, come from one of the first studies to examine the relationship of hunger and anger,Viren Swami, lead author and social psychology professor at Anglia Ruskin University in the U.K., told USA TODAY via email. (Mendoza, 7/7)

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First Edition: July 8, 2022 - Kaiser Health News

Blood Group Typing Market: Increase in Blood Transfusion Rate Across the World to Drive the Market – BioSpace

Posted on July 8, 2022 by Danzig

Wilmington, Delaware, United States, Transparency Market Research Inc.: Transparency Market Research (TMR) has published a new report titled, Blood Group Typing Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2018 to 2026. According to the report, the global blood group typing market was valued at US$ 1,500.0 Mn in 2017 and is projected to reach US$ 3,556.0 Mn by 2026, expanding at a high CAGR of 10.3% from 2018 to 2026. Increase in blood transfusion rate across the world is anticipated to fuel the global blood group typing market during the forecast period.

North America and Europe are expected to dominate the global market during the forecast period. The market in these regions is primarily driven by the increase in government initiatives and a highly structured health care industry. The market in Europe is projected to expand at a high growth rate of 10.1% from 2018 to 2026. The market in Asia Pacific is expected to expand at a rapid pace during the forecast period. The market in Asia Pacific is anticipated to expand at a high CAGR of 10.7% from 2018 to 2026. The blood group typing market in Latin America is likely to expand at a moderate growth rate during the forecast period.

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Increase in preference for PCR-based technique to boost market

In terms of technique, the PCR-based segment is projected to account for a dominant share of the global blood group typing market during the forecast period. The segment is anticipated to expand at a CAGR of 10.6% from 2018 to 2026. Dominance of the segment is attributed to the increasing preference for PCR-based technique because of rising incidence of major chronic diseases such as aplastic anemia, sickle cell anemia, leukemia, and traumatic injuries, resulting increase in blood transfusion rate in countries across the globe.

Additionally, increasing the usage of PCR-based technique in the detection of rare type of blood group is a key factor that is expected to fuel the segment. The microarray-based segment held a major share of the market, following the PCR-based segment, due to increasing awareness about this technique. Assay-based technique and massively parallel technique segments accounted for around 30.0% share of the global blood group typing market, in terms of revenue, in 2017.

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Consumables segment dominates the market

The report offers detailed segmentation of the global blood group typing market based on product, technique, test, and end-user. In terms of product, the market has been classified into instrument (automated, semi-automated, and manual), consumables (reagent, test kits, antisera, others), and services. The consumables segment is estimated to hold a leading share of the global market during the forecast period. Higher share held by the segment is attributed to the constant development of new molecular diagnostic test kits and reagents, which reduces the turnaround time required for results, and increase in number of blood transfusions, globally, every year are key factors fueling the consumables segment.

Antibody screening test & ABO blood test: Top two test employed for blood group typing

In terms of test, the antibody screening test segment is projected to hold a dominant share of global blood group typing market by the end of the forecast period. The segment is likely to expand at a CAGR more than 10.0% between 2018 and 2026. Major factor responsible for the dominance of this segment is the rise in incidence of transfusion transmitted infections (TTIs), especially in lower-middle income and low-income countries. The ABO blood test segment held a major share, following the antibody screening test, due to increasing utilization of this test for blood grouping. HLA typing and antigen segments accounted for around 30.0% share of the global blood group typing market, in terms of revenue, in 2017.

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Hospital segment to expand at significant CAGR

Based on end-user, the hospital segment accounted for a leading share of the global blood group typing market in 2017. It is projected to gain market share by the end of 2026. The segment is anticipated to expand at a CAGR of 10% during the forecast period due to the large patient population undergoing surgical procedures in hospitals requiring blood transfusion, and increasing emphasis on blood grouping and patient testing. Clinical laboratories was a prominent segment, following the hospital segment, of the market in 2017. This is due to the rise in number of clinical laboratories for blood grouping and screening. This, in turn, is likely to drive the clinical laboratories segment during the forecast period.

North America to be highly lucrative market for blood group typing market

The blood group typing market in North America is driven by high percentage of active and voluntary blood donors in the U.S. and Canada, increasing number of blood transfusions per year in the region, and various blood transfusion policies being implemented regarding safety and testing of blood for infectious diseases. This, in turn, is further boosting the demand for blood grouping instruments and kits and reagents in North America. Moreover, a large number of players in the U.S. are focusing on R&D in order to introduce new products. The U.S. is an early adopter of innovative products, as most pharmaceutical products are first launched in the country. This is likely to boost the market in the country in the near future.

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Trend of strategic alliance with local companies to strengthen distribution network and expand geographic presence

The global blood group typing market is fragmented, owing to the presence of several small- and large-scale companies. However, the market is dominated by a few major players with strong global presence. The report provides profiles of leading players operating in the global blood group typing market. Key players in the market include Grifols, S. A., Bio-Rad Laboratories, Inc., Merck KGaA, Ortho Clinical Diagnostics, QUOTIENT LIMITED, BAG Health Care GmbH, Immucor, Inc., Beckman Coulter, Inc. (Danaher Corporation), Agena Bioscience, Inc., Rapid Labs Ltd, and Novacyt Group.

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Blood Group Typing Market: Increase in Blood Transfusion Rate Across the World to Drive the Market - BioSpace

Play the Best Cryptocurrency Roulette – Eye On Annapolis – Eye On Annapolis

Posted on July 8, 2022 by Danzig

With the advent of the Internet in the 1990s, the first video game to reach the level of commercial success was roulette. It was a computer program that randomly selected numbers and allowed for placing bets on the various numbers as if the player was playing roulette in reality. However, this game became very popular only after the release of video games with a high level of difficulty. Since its launch date, roulette remains one of the most popular games for players from around the globe.

The number of people interested in playing roulette has increased significantly. Today, popular crypto casinos offer cryptocurrency roulette as part of their gambling assortment. If you are up for giving a try to an online roulette game, let us help you make your gambling experience as smooth and effective as possible. In this post, we will look into what it takes to win in the game and how to make your gameplay successful.

Roulette is played with a large wheel with 37 slots numbered from 0 to 36 being on it. The game has several types of bets that can be made with either one or several numbers. A player can place bets on zero, on a single number, or on one or several numbers at once. The main goal in the game is to predict a cell on a roulette wheel where the ball will land. Of course, the more bets you make, the higher your winning chances will be. But keep in mind that you will have to pay for each bet. So, make a balanced decision in this regard.

There are a total of 36 cells on a gaming wheel, and any number can be chosen for a bet. When placing a bet, make sure that you are aware of the min and max limits and that you stick to the general rules. Otherwise, an online casino will not be able to accept your bet, and you may lose an opportunity to land a grand prize in the game.

Apart from the above bets, there is a certain number of no wagers that can be placed, which includes the double bet. As a rule, these wagers are placed with a maximum bet and, when a number matches the winning combo, the winnings are added to your bankroll. The sum of these different wagers results in the payouts. Since roulette is a game of luck, it is almost impossible to predict a winning combo. But staying attentive to a roulette wheel is always a good thing. This approach will help you read the winning sequence and the most potentially profitable winning combos. Thats why it is always best to start your gameplay for free and then switch to BTC bets.

7BitCasino casino offers both mobile and desktop versions of your favorite game, and you can switch between different game types with just one click. So, once you feel bored with playing European roulette, you can go to an American version of the game. If you are done there as well, there are live dealer game variations run by different dealers.

Another reason why you should choose 7BitCasino is live dealer roulette. And there is more than just one live dealer roulette game at your disposal, where the actual betting and random selection of numbers take place in real-time. So, if you want to feel the atmosphere of a real land-based casino and freely communicate with a croupier, then this is a good option. On top of that, it is worth mentioning that 7BitCasino uses the most modern software to give players the best experience, which is quite promising.

Roulette is becoming more and more popular because the game itself is simple. This is the first thing that will be attractive to new and inexperienced players. In addition, this game offers players many opportunities to win. Therefore, if you are looking for simple but at the same time interesting crypto casino gambling entertainment, then roulette is the best choice.

Category: Local News, NEWS

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Play the Best Cryptocurrency Roulette - Eye On Annapolis - Eye On Annapolis

Origin of the Roulette Wheel Sonoma Sun | Sonoma, CA – Sonoma Valley Sun

Posted on July 8, 2022 by Danzig

Posted on July 2, 2022 by Allen Brown

It is still a mystery about the origin of the Roulette wheel, but a few theories have been going around regarding the same. The most popular and widely believed by the majority is that the game was created by the French Math Wizard named Blaise Pascal in the 17th century. He was not trying to invent a casino game but the perpetual motion machine. Pascal was an inventor and had lots of ideas, but this one failed. But, in the process, it gave birth to the most popular casino game to date.

However, some evidence shows that several other ancient civilizations already played the game, which was quite similar to modern-day roulette.

Soldiers Killing Time in Rome:

Ancient Roman soldiers did not have an exciting life as it was already short due to their occupational hazards, and they had to watch their friends getting injured or dead in the battle. Their morals were down, which further reduced their effectiveness on the battlefield. Hence Roman commanders let the soldiers have as much fun as possible by even participating in gambling games, and many of those games involved spinning a chariot wheel which could be the origin of roulette.

The Chinese Theory:

Several people have very different beliefs. According to them, the Chinese board game that included 37 animal figurines into a magic square which, when totaled, was 666, is what inspired roulette. The modern roulette wheel adds up to 666, which does not seem coincidental to many. The game was discovered by Dominican monks and later brought to Europe. Slight modifications were made later on to form the roulette.

Ancient Greeks Soldiers Were Gambling Too:

Greek soldiers also had gambling games to boost their morals during battles. One of their games is pretty similar to modern-day roulette. They played the game with a shield by drawing symbols inside the shield, then putting it face down on the ground by placing an arrow next to it. The shield would be spun, and the bet would be on the symbol that the arrow points to. Does this not sound very similar to roulette? These soldier games resemble the modern roulette very closely, but there is not much evidence that could support these theories.

The Addition of Zero:

The name suggests that roulette is of French origin, and the design and gameplay are influenced by two similar games popular in 17th century Europe named Roly Poly and Even-Odd, as these games involved spinning the wheel and betting on the outcome of the spin. Pascals interest in gambling was well known, making the origin story more convincing.

A fun fact is that the original roulette created by Pascal did not include zero. It was later added in the mid-9th century when Francois and Lois Blanc designed a roulette wheel with a single zero, giving the house a bigger edge. Meanwhile, King Charles III of Monaco was facing financial troubles and built a casino and bought a roulette wheel to solve the problem. This made the game popular among aristocrats and royalty.At the same time, gambling was outlawed in France, which made gambling in Monte Carlo more desirable.

Roulette Comes to America:

In the 1800s, roulette made it across the ocean to the U.S. shores as European settlers who had landed in Louisiana introduced it to the Americans. However, the casino game was not as smoothly accepted in the U.S. as it did in Europe, as the casino providers were unhappy with a 5.26% house edge. Hence, they increased it by adding double zero to the Roulette wheel. This means instead of 37 numbers that you could see on the European wheel, the American Roulette wheel would have 38 numbers (1 through 36, 0, and 00). However, this annoyed the players as they lost interest due to low earnings and started playing games they could actually beat, like blackjack.

Roulette in Online Casinos:

As gambling became popular, online gambling would surely succeed, as it offered players to enjoy thousands of games from their homes. Mostly slots rule most online casinos, but they also offer table games, and roulette and its variants always make the cut because of its popularity. It is a classic game that many gamblers enjoy to date. Also, the advent of live online casinos has even made it much more interesting, as the players get the feel of actually playing inside a land casino. Different types of roulette, such as European and American, can be played despite geographical location, which is another advantage of playing online.

The Bottom Line:

Roulette is one of the oldest casino games and is still popular amongst gambling players. It is a game of chance without proven strategies to beat it, but spinning the wheel has its own charm. Our ancestors knew the excitement players have after spinning the wheel and waiting to get lucky, which is why this game is amongst the greater casino games even today.

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Origin of the Roulette Wheel Sonoma Sun | Sonoma, CA - Sonoma Valley Sun

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Origin of the Roulette Wheel Sonoma Sun | Sonoma, CA – Sonoma Valley Sun