Pierre-Andre Jacinthe of Indiana University Purdue University Indianapolis (IUPUI) selected as AAAS S&T Policy Fellow – EurekAlert

image:Pierre-Andre Jacinthe of Indiana University Purdue University Indianapolis (IUPUI) Selected as AAAS S&T Policy Fellow view more

Credit: IUPUI School of Science

The American Association for the Advancement of Science (AAAS) is pleased to announce the 50th class of the Science & Technology Policy Fellowships (STPF), who will help inform actionable, science-based policies throughout the U.S. government. Among the 300 highly trained scientists and engineers selected, Dr. Pierre-Andre Jacinthe, a professor of soil biogeochemistry in the Department of Earth Sciences at IUPUI, will spend a year serving at the U.S. Agency for International Development (USAID) in the Bureau for Resilience and Food Security (BFS). The Bureau leads the implementation of Feed the Future, the U.S. Governments program to sustainably reduce global hunger, malnutrition and poverty through agriculture-led economic growth.

Climate change poses a real challenge to food production systems, and more so in the resource-poor regions of the world, Jacinthe said. Feed the Future has a special focus on these vulnerable communities and strives for the emergence of sustainable production systems that are resilient to climate-related stresses. I am both excited and honored to have the opportunity to contribute to the BFS mission.

Fellows like Dr. Jacinthe will learn first-hand about federal policymaking and implementation, while the U.S. government benefits from the contributions of highly trained scientists and engineers.

AAAS policy fellows have been demonstrating excellence in science policy for the past half-century defining what it means to be a scientist and engineer in the policymaking realm, said Rashada Alexander, Ph.D., STPF director and alumna fellow. In our 50th year of partnership with the U.S. government and many esteemed scientific societies and supporters, we are excited to usher in the newest class and follow their important contributions to policy, science and society.

The STPF program supports evidence-based policymaking by leveraging the knowledge and analytical mindset of science and engineering experts, and trains leaders for a strong U.S. science and technology enterprise. Fellows represent a full spectrum disciplines, backgrounds and career stages.

We are incredibly proud of Dr. Jacinthe and his remarkable accomplishment of being selected as an AAAS Science & Technology Policy Fellow, said John DiTusa, dean of the IUPUI School of Science. This is a wonderful recognition of the quality of his previous work in the field of biogeochemistry of soils as a faculty member of the School of Science. I know Dr. Jacinthes important work with the BFS on the impact of climate change on soil biochemistry and on food production will lead to crucial scientific contributions for policy development worldwide and inform future exploration.

The 2022-23 fellowship class is sponsored by AAAS, the Moore Foundation and partner societies. Of the 300 fellows chosen, 31 will serve in Congress, one will serve at the Federal Judicial Center, and 268 will serve in the executive branch among 19 federal agencies or departments.

After the fellowship, many remain in the policy arena working at the federal, state, regional or international level, while others pursue careers in academia, industry or the nonprofit sector.

Founded in 1973, the STPF program will turn 50 in 2023. AAAS will celebrate this milestone as STPF establishes a formal alumni network about 4,000 strong to stimulate and support collaboration among alumni fellows to further the STPF mission to connect evidence-based decision-making with public policy.

Visit http://www.aaas.org/stpf to learn more about the AAAS S&T Policy Fellowships.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

See the original post:
Pierre-Andre Jacinthe of Indiana University Purdue University Indianapolis (IUPUI) selected as AAAS S&T Policy Fellow - EurekAlert

Atavistik Bio Announces Formation of Scientific Advisory Board – Business Wire

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Atavistik Bio, a pre-clinical biotechnology company that is leveraging their scalable and systematic platform to identify novel regulatory sites on proteins to restore function in disease, announced the formation of its Scientific Advisory Board (SAB) comprised of distinguished leaders in protein sciences, inborn errors of metabolism, and cancer.

We are proud and honored to have these accomplished scientific leaders join our Scientific Advisory Board, said Marion Dorsch, President and CSO of Atavistik Bio. Together, they bring a wealth of knowledge and experience for Atavistik Bio as we leverage our powerful screening and analytics platforms to unlock the potential of protein-metabolite interactions with the goal to bring transformative therapies to patients. Atavistik Bio looks forward to the input of these outstanding scientists and their contribution to our research and development efforts. Feedback and collaboration with our SAB will be critical to advance our efforts to develop therapies to patients in need. It is a very exciting time for all of us at Atavistik Bio.

The founding members of the Atavistik Bio Scientific Advisory Board are:

Dr. Ralph DeBerardinis is Chief of Pediatric Genetics and Metabolism at UT Southwestern Medical Center (UTSW) and Director of the Genetic and Metabolic Disease Program at Childrens Medical Center Research Institute at UTSW (CRI). His laboratory studies the role of altered metabolic pathways in human diseases, including cancer and pediatric inborn errors of metabolism. Work from the DeBerardinis laboratory has produced new insights into disease mechanisms in numerous metabolic diseases, including by defining unexpected fuel preferences in human cancer and uncovering new metabolic vulnerabilities in cancer cells. Dr. DeBerardinis is a Howard Hughes Medical Institute Investigator and has received numerous awards including the William K. Bowes, Jr. Award in Medical Genetics, the National Cancer Institutes Outstanding Investigator Award, The Academy of Medicine, Engineering & Science of Texass Edith and Peter ODonnell Award in Medicine, and the Paul Marks Prize for Cancer Research from Memorial Sloan Kettering Cancer Center. He has been elected to the National Academy of Medicine and the Association of American Physicians.

Dr. DeBerardinis received a BS in Biology from St. Josephs University in Philadelphia before earning MD and PhD degrees from the University of Pennsylvanias School of Medicine. He completed his medical residency and post-doctoral training at The Childrens Hospital of Philadelphia (CHOP) in Pediatrics, Medical Genetics and Clinical Biochemical Genetics.

Dr. Jared Rutter is a Distinguished Professor of Biochemistry and holds the Dee Glen and Ida Smith Endowed Chair for Cancer Research at the University of Utah where he has been on the faculty since 2003. His laboratory has identified the functions of several previously uncharacterized mitochondrial proteins, including the discovery of the long-sought mitochondrial pyruvate carrier. This knowledge has demonstrated that this critical metabolic step is impaired in a variety of human diseases, including cancer and cardiovascular disease. In addition, the Rutter lab is taking multiple approaches to understand how metabolic state influences cell fate and cell behavior decisions. Dr. Rutter has been an Investigator of the Howard Hughes Medical Institute since 2015 and serves as co-Director of the Diabetes and Metabolism Center at the University of Utah and co-Leader of the Nuclear Control of Cell Growth and Differentiation at Huntsman Cancer Institute.

Dr. Rutter performed undergraduate studies at Brigham Young University and received his PhD from the University of Texas Southwestern Medical Center in 2001, working with Dr. Steve McKnight. After receiving his PhD, he spent 18 months as the Sara and Frank McKnight Independent Fellow of Biochemistry before joining the faculty at the University of Utah.

Karen Allen, Ph.D. is Professor and Chair of Chemistry at Boston University. For over 25 years, she has led research teams at Boston University, in the Departments of Physiology and Biophysics at the School of Medicine, and Chemistry. She is also a Professor of Material Science and Engineering and on the faculty of the Bioinformatics program at Boston University. The structure-aided design approach in the Allen lab encompasses the use of macromolecular X-ray crystallography, small-angle X-ray scattering, molecular modeling, and kinetics.

Karen received her B.S. degree in Biology, from Tufts University and her Ph.D. in Biochemistry from Brandeis University in the laboratory of the mechanistic enzymologist, Dr. Robert H. Abeles. Following her desire to see enzymes in action she pursued X-ray crystallography during postdoctoral studies as an American Cancer Society Fellow in the laboratory of Drs. Gregory A. Petsko and Dagmar Ringe.

Kivanc Birsoy, Ph.D. is a Chapman-Perelman Associate Professor at Rockefeller University. His research at Rockefeller focuses on how cancer cells rewire their metabolic pathways to adapt to environmental stresses during tumorigenesis and other pathological states. He is the recipient of numerous awards, including the Leukemia and Lymphoma Society Special Fellow award, Margaret and Herman Sokol Award, NIH Career Transition Award, Irma Hirschl/Monique Weill-Caulier Trusts Award, Sidney Kimmel Cancer Foundation Scholar Award, March of Dimes Basil OConnor Scholar Award, AACR NextGen award for Transformative Cancer Research, Searle Scholar, Pew-Stewart Scholarship for Cancer Research and NIH Directors New Innovator Award.

Kivanc received his undergraduate degree in Molecular Genetics from Bilkent University in Turkey in 2004 and his Ph.D. from the Rockefeller University in 2009, where he studied the molecular genetics of obesity in the laboratory of Jeffrey Friedman. In 2010, he joined the laboratory of David Sabatini at the Whitehead Institute of Massachusetts Institute of Technology (MIT) where he combined forward genetics and metabolomics approaches to understand how different cancer types rewire their metabolism to adapt nutrient deprived environments.

Benjamin Cravatt, Ph.D. is the Gilula Chair of Chemical Biology and Professor in the Department of Chemistry at The Scripps Research Institute. His research group develops and applies chemical proteomic technologies for protein and drug discovery on a global scale and has particular interest in studying biochemical pathways in cancer and the nervous system. His honors include a Searle Scholar Award, the Eli Lilly Award in Biological Chemistry, a Cope Scholar Award, the ASBMB Merck Award, the Wolf Prize in Chemistry, and memberships in the National Academy of Sciences, National Academy of Medicine, and American Academy of Arts and Sciences. Ben is a co-founder of several biotechnology companies, including Activx Biosciences (acquired by Kyorin Pharmaceuticals), Abide Therapeutics (acquired by Lundbeck Pharmaceuticals), Vividion Therapeutics (Acquired by Bayer Pharmaceuticals), Boundless Bio, Kisbee Therapeutics, and Kojin Therapeutics.

Ben obtained his undergraduate education at Stanford University, receiving a B.S. in the Biological Sciences and a B.A. in History. He then received a Ph.D. from The Scripps Research Institute (TSRI) in 1996, and joined the faculty at TSRI in 1997.

The SAB will be co-chaired by Dr. DeBerardinis and Dr. Rutter, the scientific founders of Atavistik Bio, and work closely with the company to advance their leading-edge metabolite protein screening platform discovery programs. Im delighted to be appointed Co-Chair of Atavistik Bios Scientific Advisory Board, and to be part of such a distinguished group of experts, said Dr. DeBerardinis. Together we aim to guide Atavistik Bio through the development of its pipeline while maximizing the potential of the companys technology platform, stated Dr. Rutter.

About Atavistik Bio

Atavistik Bio is a pre-clinical biotechnology company that is harnessing the power of protein-metabolite interactions to add a new lens to drug discovery with the aim of transforming the lives of patients. By leveraging its optimized Atavistik Metabolite Protein Screening (AMPS) platform and computational approaches, Atavistik Bio aims to evaluate metabolite-protein interactions by screening proteins with their proprietary metabolite library to determine where binding sites with biological relevance might exist. This will enable Atavistik Bio to build an extensive protein-metabolite database map (the Interactome) to reveal unique insights into the crosstalk between metabolite-protein pathways that were previously thought to be unrelated. Utilizing advanced informatics tools, deep expertise in chemistry and computationally rich structure-based drug design, Atavistik Bio will be able to identify and understand the role of these interactions across important biological and disease-relevant pathways to drive the discovery of novel therapeutics with an initial focus on inborn errors of metabolism and cancer. Atavistik Bio is located in Cambridge, Massachusetts. For more information, visit http://www.atavistikbio.com.

See original here:
Atavistik Bio Announces Formation of Scientific Advisory Board - Business Wire

Postdoctoral Fellowship in Synthetic Biology job with NORWEGIAN UNIVERSITY OF SCIENCE & TECHNOLOGY – NTNU | 309904 – Times Higher Education

About the position

The postdoctoral fellowshipposition is atemporaryposition where the main goal is to qualify for work in senior academic positions.

We are seeking candidates with strong interest in bioengineering holding a PhD degree (or having submitted the PhD thesis) in biotechnology, biochemistry or related fields.

The research activities will be part of the PolySpore project funded by the NovoNordisk Foundation. In the project we will develop novel biological and hybrid materials as well as new data-storage concepts using bacterial spores. The researcher will work on genetically optimizing and manipulating spores of the Gram-positive bacterium Bacillus subtilis to present and produce load bearing proteins and characterize the resulting product, as well as to work on light driven catalysis using enzymes and upconverting nanoparticles.

Some aspects of the project are examined in collaboration with partners from France and Lithuania.

Your immediate leader is Assoc.Prof. Johannes Kabisch.

Duties of the position

Requiredselectioncriteria

The appointment is to be made in accordance withRegulations on terms of employment for positions such as postdoctoral fellow, Ph.D Candidate, research assistant and specialist candidate.

Preferred selection criteria

Personal characteristics

Emphasis will be placed on personal and interpersonal qualities.

Weoffer

Salary and conditions

As a Postdoctoral Fellow (code 1352) you are normally paid from gross NOK 563 500 per annum before tax, depending on qualifications and seniority. From the salary, 2 % is deducted as a contribution to the Norwegian Public Service Pension Fund

The period of employment is 2,5 years.

The engagement is to be made in accordance with the regulations in force concerningState Employees and Civil Servants, and the acts relating to Control of the Export of Strategic Goods, Services and Technology. Candidates who by assessment of the application and attachment are seen to conflict with the criteria in the latter law will be prohibited from recruitment to NTNU.

After the appointment you must assume that there may be changes in the area of work.

The position is subject to external funding.

It is a prerequisite you can be present at and accessible to the institution on a daily basis.

About the application

The application and supporting documentation to be used as the basis for the assessment must be in English.

Publications and other scientific work must follow the application.Please note that applications are only evaluated based on the information available on the application deadline. You should ensure that your application shows clearly how your skills and experience meet the criteria which are set out above.

If, for any reason, you have taken a career break or have had an atypical career and wish to disclose this in your application, the selection committee will take this into account, recognizing that the quantity of your research may be reduced as a result.

The application must include :

If all,or parts,of your education has been taken abroad, we also ask you to attach documentation of the scope and quality of your entire education.Description of the documentation required can befoundhere. If you already have a statement from NOKUT,pleaseattachthisas well.

Joint works will be considered. If it is difficult to identify your contribution to joint works, you must attach a brief description of your participation.

In the evaluation of which candidate is best qualified, emphasis will be placed on education, experienceand personal and interpersonalqualities.Motivation,ambitions,and potential will also countin the assessment ofthe candidates.

NTNU is committed to following evaluation criteria for research quality according toThe San Francisco Declaration on Research Assessment - DORA.

General information

Working at NTNU

NTNU believes that inclusion and diversity is a strength. We want our faculty and staff to reflect Norways culturally diverse population and we continuously seek to hire the best minds. This enables NTNU to increase productivity and innovation, improve decision making processes, raise employee satisfaction, compete academically with global top-ranking institutions and carry out our social responsibilities within education and research. NTNU emphasizes accessibility and encourages qualified candidates to apply regardless of gender identity, ability status, periods of unemployment or ethnic and cultural background.

The city of Trondheimis a modern European city with a rich cultural scene. Trondheim is the innovation capital of Norway with a population of 200,000.The Norwegian welfare state, including healthcare, schools, kindergartens and overall equality, is probably the best of its kind in the world. Professional subsidized day-care for children is easily available. Furthermore, Trondheim offers great opportunities for education (including international schools) and possibilities to enjoy nature, culture and family life and has low crime rates and clean air quality.

As an employeeatNTNU, you mustat all timesadhere to the changes that the development in the subject entails and the organizational changes that are adopted.

A public list of applicants with name, age, job title and municipality of residence is prepared after the application deadline. If you want to reserve yourself from entry on the public applicant list, this must be justified. Assessment will be made in accordance withcurrent legislation. You will be notified if the reservation is not accepted.

If you have any questions about the position, please contact Assoc.Prof. Johannes Kabisch, email: johannes.kabisch@ntnu.no.

If you think this looks interesting and in line with your qualifications, please submit your application electronically via jobbnorge.no with your CV, diplomas and certificates attached. Applications submitted elsewhere will not be considered.Upon request, you must be able to obtain certified copies of your documentation.

Application deadline: 17.10.2022

NTNU

NTNU - knowledge for a better world

The Norwegian University of Science and Technology (NTNU) creates knowledge for a better world and solutions that can change everyday life.

Department of Biotechnology and Food Science

Our activities contribute to increased exploitation of existing and new ingredients for sustainable food production as well as next-generation energy solutions and medical technology. We educate graduates for a wide range of careers in industry, public administration and academia.The Department of Biotechnology and Food Scienceis one of eight departments in theFaculty of Natural Sciences.

Deadline17th October 2022EmployerNTNU - Norwegian University of Science and TechnologyMunicipalityTrondheimScopeFulltimeDuration TemporaryPlace of service Glshaugen

Read more:
Postdoctoral Fellowship in Synthetic Biology job with NORWEGIAN UNIVERSITY OF SCIENCE & TECHNOLOGY - NTNU | 309904 - Times Higher Education

Breakthrough RNA-Based Anti-Cancer Immunotherapy Treatments Being Developed by Global Consortium led by the Hadassah Cancer Research Institute -…

JERUSALEM, Sept. 19, 2022 /PRNewswire/ -- The Hadassah Cancer Research Institute (HCRI) at the Hadassah University Medical Center in Jerusalem, announced today that it is leading CancerRNA (www.cancerna.info), a global consortium that aims to apply RNA-based therapeutics to successfully unlock anti-cancer immune responses. While RNA-based therapies, namely mRNA vaccines, shined during the pandemic and saved millions of lives, they have yet to be successfully tested in cancer therapies. The HCRI hosted the opening meeting and workshops of CancerRNA in Jerusalem this month to plan, collaborate and advance the aims of this groundbreaking international consortium to impact the future of cancer treatment.

The CanceRNA team, led by Professor Michal Lotem, MD, Head of HCRI, the Center for Melanoma and Cancer Immunotherapy, and Prof. Rotem Karni Department Chair at Biochemistry and Molecular Biology, Hebrew University-Hadassah Medical School, will focus on two main goals. First, will be harnessing the modulation of RNA processing to increase the immunogenicity of "cold" cancers which lack genomic mutations, to exploit abnormal transcripts and evoke immune response; and second, enhancing the activity of the immune system by retargeting immune effector cells, modulating RNA splicing of key immune receptors and developing personalized mRNA vaccines.

This multi-disciplined team is composed of international leaders in the fields of RNA research, clinicians and biotech-pharma experts in RNA processing, RNA drug design and delivery, biocomputing and immuno-oncology: Wolf Prize Laureate Prof. Lynne Maquat of the University of Rochester; Prof. Maria Carmo Fonseca of the University of Lisbon; Prof. Juan Valcarcel of the Center for Genomic Regulation in Barcelona; Prof. Tanja DeGruijl of the University of Amsterdam; Prof. Niels Schaft of the University of Erlangen; Erez Levanon of Bar Ilan University; Seth Salpeter of Immunyx; Pablo Menendez of Jose Carreras Leukemia Institute in Spain; Evelien Smits of the University of Brussels; and Regine Shevach, Simon Geissler and Daniel Helman of Merck.

"CanceRNA will initially focus on two cancer types, acute myeloid leukemia, relevant for pediatric cancer, and uveal melanoma, both of which harbor splicing factor mutations and that are generally refractory to immunotherapy," said Professor Lotem. "Our hope is to utilize RNA-based therapeutics to overcome what until now, have been key barriers to successful anti-cancer immune responses. "

"The combination of experts from all over Europe in the fields of RNA biology, immunology, bioinformatics and drug transport will propel the development of the next generation of immunotherapy cancer treatments," added co-CanceRNA leader, Professor Rotem Karni, Chair of the Biochemistry and Molecular Biology Department at the Hebrew University-Hadassah Medical School.

Visit http://www.cancerna.info, for more information on CanceRNA.

About CanceRNA:

CanceRNA aims to impact the future of cancer treatment by developing and validating novel RNA-based therapeutics. This three-year project comprises multi-disciplinary activities to assess in-vitro and in-vivo validation, bioinformatics, delivery, and safety based on new and effective modalities of immunotherapy for cancer treatment. The CanceRNA team of researchers and scientists will be harnessing the modulation of RNA processing to enhance the accessibility and immune susceptibility of the tumor and its microenvironment, while working to enhance the activity of the immune system by retargeting immune effector cells, modulating RNA splicing of key immune receptors and developing personalized mRNA vaccines. For more information, http://www.cancerna.info.

About the Hadassah Cancer Research Institute:

Hadassah Cancer Research Institute (HCRI) is a translational research arm of Hadassah Medical Organization and Sharett Cancer Center in Jerusalem. Discoveries made in HCRI labs are a driver of clinical progress and beyond. With advanced labs focused on excellence areas of research in: Immuno Oncology, Cancer Epigenetics, Early Cancer Detection, Cell Therapy, Bioinformatics and a Biobank, our physicians and researchers are developing a multi-disciplined, multi-institution approach to discovering the next-generation treatments to fight cancer.

For additional information on the Hadassah Cancer Research Institute and CanceRNA, contact:

Amalia Herszkowicz, Chief Operating Officer, HCRI, Communication Officer, CanceRNAHadassah Cancer Research Institute (HCRI)[emailprotected]

View original content:https://www.prnewswire.com/news-releases/breakthrough-rna-based-anti-cancer-immunotherapy-treatments-being-developed-by-global-consortium-led-by-the-hadassah-cancer-research-institute-301627084.html

SOURCE Yoya Com LTD

More here:
Breakthrough RNA-Based Anti-Cancer Immunotherapy Treatments Being Developed by Global Consortium led by the Hadassah Cancer Research Institute -...

Will rapid COVID tests be able to detect new variants? – Futurity: Research News

Share this Article

You are free to share this article under the Attribution 4.0 International license.

New research evaluates how rapid tests will perform when challenged with future SARS-CoV-2 variants.

The availability of rapid antigen tests has significantly advanced efforts to contain the spread of COVID-19. But every new variant of concern raises questions about whether diagnostic tests will still be effective.

The new study in Cell attempts to answer these questions.

The researchers developed a novel method for evaluating how mutations to SARS-CoV-2 can affect recognition by antibodies used in rapid antigen tests.

Because most rapid antigen tests detect the SARS-CoV-2 nucleocapsid protein (N protein), the team directly measured how mutations to the N protein affected diagnostic antibodies ability to recognize their target.

Based on our findings, none of the major past and present SARS-CoV-2 variants of concern contain mutations that would affect the capability of current rapid antigen tests to detect antibodies, says first author Filipp Frank, an assistant professor in the department of biochemistry at Emory University. Further, these data allow us to look one step ahead and predict test performance against almost any variant that may arise.

The study used a method called deep mutational scanning to evaluate all possible mutations in the N protein in a single, high-throughput experiment. Researchers then measured the impact of the mutations on their interaction with antibodies used in 11 commercially available rapid antigen tests and identified mutations that may allow for antibody escape.

Accurate and efficient identification of infected individuals remains a critically important strategy for COVID-19 mitigation, and our study provides information about future SARS-CoV-2 mutations that may interfere with detection, says senior study author Eric Ortlund, a professor in the department of biochemistry. The results outlined here can allow us to quickly adapt to the virus as new variants continue to emerge, representing an immediate clinical and public health impact.

Findings show that its relatively rare for variants to have mutations to the N protein that allow them to evade diagnostic tests, but there are a small proportion of sequences that could affect detection. Researchers, public health officials, and test manufacturers can use these data to determine if a diagnostic test needs to be evaluated for its ability to detect these mutations or to inform future test design.

Considering the endless cycle of new variants, the data from this study will be useful for years to come, says Bruce J. Tromberg, director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) and lead for the Rapid Acceleration of Diagnostics (RADx) Tech program at National Institutes of Health.

While many variants of concern contain multiple mutations to the N protein, the study authors note that their method does not evaluate how multiple mutations could affect diagnostic antibody recognition, representing a limitation of the study.

Support for the project came from NIBIB as part of the RADx initiative.

Source: Emory University

Read more here:
Will rapid COVID tests be able to detect new variants? - Futurity: Research News

Metal chelating and anti-radical activity of Salvia officinalis in the ameliorative effects against uranium toxicity | Scientific Reports – Nature.com

DPPH scavenging and metal chelating activity of sage

In order to support the protective role of sage against uranyl acetate toxicity, DPPH scavenging and metal chelating activities, which indicate antioxidant activity, were investigated and the results are given in Fig.2. DPPH is a stable free radical in aqueous solutions, and the decrease in the absorbance of the DPPH radical indicates antioxidant activity. Sage was determined to exhibit a dose-dependent increasing DPPH scavenging effect. DPPH scavenging activities of 200mg/mL sage, BHA and BHT were determined as 72.9%, 67.9% and 89.1%, respectively. The metal chelating activities of sage and standards were determined by evaluating their ability to compete with ferrozine for the ferrous ions. A dose-dependent increasing activity was also obtained in metal chelating activity. Metal chelating activities of 200mg/mL sage, BHA and BHT were determined as 82.8%, 76.3% and 88.5%, respectively. These results show that sage has a free radical scavenging activity that is higher than the standard antioxidant BHA and lower than BHT. Its high DPPH removal and metal chelating activity indicate the antiradical and metal chelating properties of sage, as well as its strong antioxidant capacity. There are also studies in the literature that draw attention to the similar features of sage. Emre et al.30 reported that different Salvia species grown in Turkiye exhibited metal chelating activity in the range of 45.080.48%. Roman et al.31 investigated the antiradical properties of S. officinalis extract and stated that it exhibited more than 85% DPPH removal activity. With the powerful antioxidant property, Sage has a protective role against much toxicity, and the results obtained in the Allium test in this study confirm this hypothesis.

DPPH scavenging (DSCA) and metal chelating activity (MCA) of sage.

The effects of uranyl acetate and sage application on selected physiological parameters are shown in Table 1. The maximum germination percentage, root length and weight gain were measured in the control group and Group II and Group III, which were exposed to two different doses of sage. No statistically significant difference was found between the physiological parameter values measured in these groups (p>0.05). In Group IV, in which 0.1mg/mL of uranyl acetate was administered, statistically significant decreases were found in all investigated physiological parameter values compared to the control group (p<0.05). It was observed that this decrease was approximately 2.1 times for germination percentage, about 7 times for root length and about 4.8 times for weight gain. The application of sage together with uranyl acetate caused a statistically significant (p<0.05) increase in the values of all investigated physiological parameters, although not as much as the control group. It was determined that these increases were more pronounced at the 380mg/L dose of sage. Compared to Group IV, germination percentage increased approximately 1.2 times, root length approximately 1.9 times and weight gain approximately 1.8 times in Group VI.

Although there is no comprehensive study in the literature on the effects of uranium or uranyl acetate application on the physiological properties of plants, there are some studies on the effects of other heavy metals. For example, avuolu et al.32 determined that Pb and Hg heavy metal application at 10 and 50ppm doses caused dose-dependent decreases in the germination percentage, root length and weight gain of Cicer arietinum L. seeds. They also reported that these decreases were more pronounced in the group exposed to the 50ppm dose of Hg. avuolu and Yaln33 determined that 25 and 50ppm doses of Al and Co application caused a dose-dependent decrease in the germination percentage, root length and weight of Phaseolus vulgaris L. cv. kidney bean seeds. They also observed that these decreases were more pronounced at the 50ppm dose of Al. Grel et al.34 observed that 2.4, 8.0 and 12.5mg/L Cr doses caused dose-related decreases in germination percentage, root length and weight gain in A. cepa. Girasun et al.35 determined that Pb application at 50, 100 and 200mg/L doses caused a dose-dependent decrease in physiological parameters such as germination percentage, root length and weight gain in A. cepa. Macar et al.36 found statistically significant reductions in germination percentage, root length and weight gain in A. cepa bulbs exposed to 5.5mg dose of Co for 72h.

In this study, it is thought that the abnormalities in physiological parameters as a result of uranium exposure are due to the reduction of A. cepa roots' intake of water and inorganic substances. Because it has been reported in the literature that high doses of heavy metal exposure in different plant species reduce the water and mineral substance uptake of the roots, and their productivity decreases by affecting the photosynthesis reactions and nitrogen metabolisms. On the other hand, it has been reported that exposure to heavy metals causes root, shoot, plant growth and plant weight reduction, deterioration of grana structure, inhibition of chlorophyll synthesis and respiration and development of apoptosis and necrosis processes in plants. ROS produced by heavy metals is shown as the main reason for the processes that encourage all these negative effects in the plant. Sage, which exhibits strong DPPH removal and metal chelating activity, protected against oxidative stress induced by uranium and exhibited a toxicity-reducing effect with its antioxidant property. It has also been stated in the literature that plants have developed some effective defense mechanisms to combat ROS-induced oxidative stress37. Therefore, it is considered that these defense mechanisms developed by A. cepa to prevent uranium from entering the cell may be another reason for the decrease in the investigated physiological parameter values. Because the excessive increases in the number/frequency of epidermis and cortex cells observed in the microscopic examination of root tip meristematic cells support this idea.

The genotoxicity induced by uranyl acetate application and the protective role of sage against this toxicity are shown in Figs. 3, 4 and Table 2. Statistically insignificant (p>0.05) MN formations were found in the control group and Group II and Group III, which were exposed to two different doses of sage. In addition, CAs in the form of a few sticky chromosome and unequal distribution of chromatin was detected in these groups, which was not statistically significant (p>0.05). On the other hand, the highest MI value (741.30, 747.90 and 743.80, respectively) was also determined in these groups. The application of 0.1mg/mL uranyl acetate caused the highest rate (82.40) of MN formation (p<0.05) in the root tip cells of the bulbs in Group IV, and promoted CAs such as fragment, vagrant chromosome, sticky chromosome, bridge and unequal distribution of chromatin and caused significant decreases (p<0.05) in the MI value. The greatest effect of uranyl acetate application on chromosomes occurred in the form of fragment formation. The application of sage together with uranyl acetate decreased the genotoxic effects of uranyl acetate, and caused a statistically significant (p<0.05) decrease in the frequencies of MN and CAs, and a significant (p<0.05) increase in the MI value, depending on the dose. It was determined that these alterations observed in the investigated genotoxic parameters were more pronounced in Group VI, where 380mg/L dose of sage was administered. Compared to Group IV, the frequency of fragment decreased approximately 1.5 times, the MN frequency decreased approximately 1.4 times, and the MI rate increased approximately 1.3 times in Group VI.

CAs induced by uranyl acetate. MN in interphase (a), fragment in metaphase (b), vagrant chromosome in anaphase (c), sticky chromosome in prophase (d), bridge in early anaphase (e), unequal distribution of chromatin in anaphase (f).

The effects of uranyl acetate and sage on DCN and MI (%). Group I: Control, Group II: 190mg/L sage, Group III: 380mg/L sage, Group IV: 0.1mg/mL uranyl acetate, Group V: 0.1mg/mL uranyl acetate+190mg/L sage, Group VI: 0.1mg/mL uranyl acetate+380mg/L sage. MI was calculated by counting 10,000 cells in each group. *indicates statistical difference between Groups I and IV, **indicates statistical difference between Groups IV and VI (p<0.05). DCN: dividing cell number, MI: mitotic index.

Although there is no comprehensive study in the literature on genotoxicity caused by exposure to uranium or uranyl acetate in plants, there are some studies conducted with experimental animals. For example, avuolu et al.38 observed MN formation in erythrocyte and buccal mucosal epithelial cells of Swiss albino mice exposed to 5mg/kg b.w of uranyl acetate by oral gavage for 5days. In addition, they reported a decrease in MI value with CAs in the form of break, fragment, gap, acentric and ring chromosomes in bone marrow cells. In addition, there are some studies in the literature investigating the genotoxicity induced by other heavy metal ions in plants. For example, avuolu et al.32 determined that exposure to Pb and Hg at two different doses (10 and 50ppm) caused an increase in the frequency of MN in C. arietinum root tip cells and promoted CAs in the form of sticky chromosome and bridge. avuolu and Yaln33 observed that exposure to Al and Co at 25 and 50ppm doses caused MN formation in P. vulgaris cv. kidney bean root cells. Grel et al.34 reported that administration of three different doses of Cr (2.4, 8.0 ve 12.5mg/L) caused a dose-dependent decrease in MI in A. cepa root tip cells. In addition, they found an increase in the frequency of MN and the numbers of CAs such as fragments, unequal distribution of chromatin, sticky chromosomes, bridges, reverse polarization and c-mitosis. Girasun et al.35 showed that exposure to three different doses (50, 100 ve 200mg/L) of Pb decreased the MI value, increased the frequency of MN, and caused damage in the form of fragments, adhesions, bridges and c-mitosis in A. cepa root tip cells, depending on the application dose. Macar et al.36 observed a decrease in MI, an increase in MN formation and an increase in the number of CAs in root tip cells of A. cepa, where 5.5mg of Co was applied. They also determined that Co application promotes CAs in the form of fragment, sticky chromosome, bridge, unequal distribution of chromatin, multipolar anaphase, nucleus damage, and irregular mitosis.

In our study, it is thought that the main reason for the decrease in MI value and the increase in the numbers of MN and CAs in Group IV treated with uranyl acetate may be due to the direct or indirect interaction of uranium with chromosomes. Because it has been reported in the literature that heavy metals disrupts the structure of DNA directly or indirectly by producing ROS, promoting DNA damages. On the other hand, some heavy metals have been reported to cause disruptions in DNA repair processes. For example, while Cr causes damage by reacting directly with DNA, As, Ni and Cd act by preventing the repair processes of DNA double-strand breaks. Damages such as MN, fragments, breaks, sister chromatid exchanges and variation are other CAs promoted by heavy metal ions39. The genotoxic and cytotoxic effects induced by uranyl acetate may be related to the occurrence of oxidative stress in general. Sage protects the integrity of the genome by reducing the oxidative load in the cell, especially with its strong metal chelating activity and antioxidant power. The reductions in MN and CAs frequencies observed in groups V and VI treated with sage+uranyl acetate confirm this idea.

The effects of uranyl acetate and sage application on selected biochemical parameters are shown in Fig.5. No statistically significant difference was observed between the root MDA levels and SOD and CAT activities of the control group and Group II and Group III exposed to two different doses of sage (p>0.05). Uranyl acetate application at 0.1mg/mL dose caused statistically significant (p<0.05) increases in root MDA level, which is an indicator of lipid peroxidation, and in SOD and CAT activities, which are antioxidant enzymes. Compared to the control group, these increases were found to be approximately 3.8 times for MDA level, approximately 3.2 times for SOD activity and approximately 2.7 times for CAT activity in Group IV. It was determined that the application of sage together with uranyl acetate again promoted statistically significant (p<0.05) decreases in MDA levels, SOD and CAT activities, depending on the dose. These decreases were even more pronounced in Group VI exposed to 380mg/L of sage. Compared to Group IV, approximately 2.1-fold decrease in MDA level, approximately 1.3-fold decrease in SOD activity and approximately 1.3-fold decrease in CAT activity was detected in Group VI.

Effect of uranyl acetate and sage application on selected biochemical parameters. Group I: Control, Group II: 190mg/L sage, Group III: 380mg/L sage, Group IV: 0.1mg/mL uranyl acetate, Group V: 0.1mg/mL uranyl acetate+190mg/L sage, Group VI: 0.1mg/mL uranyl acetate+380mg/L sage. * indicates statistical difference between Groups I and IV, ** indicates statistical difference between Groups IV and VI (p<0.05).

Although there is no comprehensive study in the literature of biochemical toxicity induced by exposure to uranium or uranyl acetate in plants, there are some studies with Swiss albino mice. avuolu et al.38 reported a significant increase in blood MDA levels and a significant decrease in GSH levels in Swiss albino mice exposed to 5mg/kg b.w of uranyl acetate by oral gavage for 5days. In a similar study, Yapar et al.40 found significant increases in MDA levels and significant decreases in GSH levels in liver and kidney tissues of Swiss albino mice exposed to 5mg/kg b.w of uranyl acetate. In addition, there are some studies dealing with the biochemical toxicity induced by other heavy metals other than uranium in plants. avuolu et al.32 reported that MDA levels in C. arietinum root tip cells exposed to Pb and Hg heavy metals at 10 and 50ppm doses increased dose-dependently, and these increases were even more pronounced at 50ppm doses of Hg. avuolu and Yaln33 stated that the application of Al and Co at two different doses (25 and 50ppm) caused dose-related increases in the MDA levels of P. vulgaris cv. kidney bean root cells, and these increases were higher et al. doses than at Co doses. Macar et al.36 observed that Co application at 5.5mg dose caused significant increases in MDA levels and SOD and CAT enzyme activities of A. cepa root tip cells.

MDA is a 3-carbon aldehyde, which is one of the most important markers of cell membrane damage, in other words, lipid peroxidation. Lipid peroxidation is a reaction caused by free radicals that cause oxidative damage of unsaturated fats. A free radical can then abstract the H atom and form an oxidized lipid free radical, producing a peroxyl radical. The peroxyl radical can remove an electron and produce a lipid hydroperoxide and another lipid free radical. This process can continue as a chain reaction. Since lipid hydroperoxide is unstable, it decomposes to form MDA and 4-hydroxy-2-nonenal products. In cases where the increase of free radicals in the cell, enzyme systems and antioxidant molecules in the cell are not sufficient for protection, these free radicals attack cell membranes, cause lipid peroxidation and increase MDA levels41. Therefore, the increase in MDA levels in A. cepa root cells treated with uranyl acetate can be explained by the fact that uranium causes free radical production and these free radicals cause damage to the membranes of the root cells.

SOD and CAT enzymes are known as antioxidants that prevent the formation of free radicals in the cell or eliminate or neutralize their effects. While the SOD enzyme neutralizes the superoxide radical, the CAT enzyme catalyzes the conversion of H2O2, which is highly toxic for the cell, into water and oxygen42. Therefore, the increase in SOD and CAT enzyme levels in A. cepa root cells exposed to uranyl acetate can be explained by the fact that uranium causes free radical production and increases SOD and CAT enzyme levels as a defense mechanism of the cell to minimize the harmful effects of free radicals. The fact that uranyl acetate increases MDA levels and induces antioxidant enzyme activities can be explained by triggering oxidative stress. The decrease observed in MDA, SOD and CAT levels in Group V and Group VI treated with sage+uranyl acetate shows that sage provides protection against the biochemical toxicity of uranyl acetate. This healing property is closely related to the antioxidant, antiradical and metal chelating activities of sage.

The effects of uranyl acetate and sage application on the root anatomy of A. cepa are shown in Fig.6 and Table 3. No damage was observed in the root meristem cells of Group II and Group III, which were exposed to two different doses of sage with the control group. In Group IV exposed to uranyl acetate at a dose of 0.1mg/mL, epidermis and cortex cell damage, as well as meristematic cell damage in the form of flattened cell nucleus were observed. Co-administration of sage with uranyl acetate caused reductions/improvements in the severity of observed meristematic cell damage by reducing the negative effects of uranyl acetate, depending on the dose. It was determined that this decrease in the severity level was more pronounced at 380mg/L dose of sage.

Meristematic cell damages induced by uranyl acetate. Normal appearance of epidermis cells (a), normal appearance of cortex cells (b), normal appearance of cell nucleus-oval (c), epidermis cell damage (d), cortex cell damage (e), flattened cell nucleus (f).

Although there is no study in the literature that deals with the anatomical changes caused by uranium or uranyl acetate exposure in plant root tip meristematic cells, there are some studies on the anatomical effects of other heavy metals. Grel et al.34 reported that 2.4, 8.0 and 12.5mg/L Cr doses caused anatomical damage in the form of cell deformation, thickening of the cortex cell wall, flattened cell nucleus and necrosis in root tip meristematic cells of A. cepa. They also stated that the severity of these damages was dose dependent. avuolu et al.43 observed anatomical damage such as cell deformation, necrosis, flattening cell nucleus, thickening of the cortex cell wall, inclearly vascular tissue and accumulation of some substances in cortex cells in A. cepa root tip meristematic cells exposed to Hg at 25, 50 and 100mg/L doses. Girasun et al.35 detected cell damage such as thickening of the cortex cell wall, cell deformation, inclearly vascular tissue and necrosis in A. cepa root tip meristem cells of 50, 100 and 200mg/L doses of Pb exposure, the severity of which increased with the application dose. Macar et al.36 reported that 5.5mg Co dose promoted damages such as epidermis cell deformation, thickening of the cortex cell wall and flattened cell nucleus in A. cepa root tip meristematic cells.

This suggests that this epidermis and cortex cell damage induced by uranium occurs as a result of the defense mechanisms developed by plants against heavy metal ions. Because the roots have increased the number and frequency of the epidermis and cortex cells in order to prevent uranium from entering the cell, and these damages may have occurred as a result of the compression/suppression of the cells. The information in the literature that plants develop different defense mechanisms against heavy metal toxicity, such as accumulation, storage and crystallization of metals in certain regions, or changes in the cell membrane and cell wall, increase in vacuole numbers and metal-binding protein synthesis44, supports our this idea.

In recent studies, different plant extracts such as lycopene, carotene, Ginkgo biloba L., green coffee, green tea and stinging nettle are used to reduce toxicity promoted by toxic agents such as heavy metal ions. In this study, sage treatment provided significant protection against the physiological, biochemical, cytogenetic and anatomical abnormalities exhibited by the application of uranyl acetate in the A. cepa root tip cells. It provided improvement in germination-related parameters such as root length and weight gain, and decreased MN and CAs frequencies, which were detected at high rates after uranyl acetate application. These improvements increased depending on the dose and the highest protection was obtained at the dose of 380mg/L. In this study, it was determined that sage has antiradical property and scavenges the DPPH radical at a rate of 72.9%. Sage is a powerful antioxidant compound, which also exhibits an important metal chelating activity. These powerful properties of sage are related to the active ingredients it contains. The greatest role in the protective role of sage is the antioxidant activity exhibited due to phenolic compounds such as carnosic acid, carnosol, rosmarinic acid and camphor in the content. There are some studies in the literature focused on the antioxidant role of sage. For example, Lima et al.45 investigated the antioxidant potential of traditional water infusion (tea) of sage in vivo in mice and rats. In conclusion, it was determined that replacing the water in the diet of rodents with sage for 14days did not affect the body weight and food consumption of the animals. They also reported that sage did not cause liver toxicity, liver GST activity was increased in rats (24% rate) and mice (10% rate) drinking sage, on the other hand, sage caused an improvement in the antioxidant status of hepatocytes, increased GSH levels and provided a protection against lipid peroxidation. Horvthov et al.46 investigated the protective effect of sage extract against oxidative stress to which liver cells of SpragueDawley rats are exposed. As a result, no negative effects were observed on basal DNA damage levels and SOD activities in hepatocyte cells of animals that drank sage for 14days, and no changes were detected in the biochemical parameters of blood plasma. On the contrary, they determined that sage extract significantly increased GPx activity, decreased DNA damage levels caused by oxidants, and provided antioxidant protection by increasing GSH levels. Alshubaily and Jambi47 investigated the possible protective role and antioxidant activity of sage extract against metabolic disorders caused by hypercholesterolemic diet in heart and testicular tissues of rats. In conclusion, they determined that the hypercholesterolemic diet significantly increased serum lipid content, cardiac marker enzyme activities, MDA levels, and significantly decreased high-density lipoprotein-cholesterol levels in testes and heart tissues. They observed that the co-administration of hypercholesterolemic diet and sage extract reduced the damage caused by the hypercholesterolemic diet by causing a decrease in lipid peroxidation, induction of heart and testis functions, and increased activity. They reported that essential oil, phenolic contents and other antioxidant components contained in sage extract were effective in this.

Read the original:
Metal chelating and anti-radical activity of Salvia officinalis in the ameliorative effects against uranium toxicity | Scientific Reports - Nature.com

Mayor Bowser and Universal Health Services Announce Plan to Expand Size of Cedar Hill Regional Medical Center, GW Health, Adding a Fourth Patient…

(Washington, DC) Today, Mayor Muriel Bowser and Universal Health Services (UHS) announced a plan to expand the size of the new Cedar Hill Regional Medical Center, GW Health in Ward 8 on the St. Elizabeths East Campus. The expansion is made possible through a $17 million investment from Universal Health Services and will allow an additional fourth patient floor and larger diagnostic and treatment to be included in the new hospital. The new floor will be able to accommodate 48 additional beds in the future, as need arises increasing the total number of beds from 136 to 184. The additional beds and diagnostic space will provide flexibility in responding to future health and regional emergencies. When it opens its doors to patients in early 2025, the new Cedar Hill Regional Medical Center, GW Health will be the first inpatient facility to open in the District in over 20 years. The state-of-the-art, full-service hospital also includes a trauma center, ambulatory pavilion for physician offices, clinics and community space, a 500-car garage, and a helipad for emergency transports.

With Cedar Hill Regional Medical Center, GW Health, we are delivering the hospital our community deserves, said Mayor Bowser. At every stage of planning this new hospital, we have been limitless in our vision for how we can build a healthier and more equitable DC. Now, we are giving that vision even more room to grow so that no matter what comes our way in the future, our state-of-the-art hospital in Ward 8 will be ready to support the needs of our community.

Advisory Neighborhood Commission 8C (adjacent to the new hospital) and Councilmember Vincent Gray, Chair of the Health Committee, are in support and the required regulatory commissions have approved of an expanded facility. Expanding the hospital will require moving the opening of the new hospital from December 2024 to early 2025. The additional floor is estimated to cost $11.5 million, paid for entirely by UHS. The expanded diagnostic and treatment area is estimated to cost $11 million and will be shared between UHS and the District, at $5.5 million each. The additions add 58,000 square feet to the hospital, for a total of 407,000 square feet.

Our investment in Cedar Hill Regional Medical Center, GW Health continues to demonstrate UHS commitment to providing a wide array of critical healthcare services East of the Anacostia River, said Kimberly Russo, MBA, MS, Group Vice President of the Washington, DC Region for UHS and Chief Executive Officer of GW Hospital. This $17 million UHS contribution is earmarked for the hospitals expansion, strategically focused on addressing the needs of the community by providing additional space for expanded diagnostic and patient treatment areas.

Services at the new 407,000 square foot Cedar Hill Regional Medical Center, GW Health will include:

I am very excited that we are building the new Cedar Hill Regional Medical Center, GW Health hospital with the shell space to grow into the nations premier community hospital with 184 beds, said Councilmember Gray. When I met with Dr. Elaine Batchlor, the CEO of the Martin Luther King, Jr. Community Hospital, in Los Angeles, she advised us to build our new hospital with room to grow. I commend Universal Health Services for funding the $17 million for this increased 48-bed capacity and larger hospital, and Mayor Bowser on her continued leadership and commitment to this transformational hospital project that will create a generational shift for health equity in the city, as part of our vision to create a comprehensive system of healthcare on the District's East End.

Named after Frederick Douglasss historic residence in Anacostia, Cedar Hill Regional Medical Center, GW Health will be fully integrated with two new urgent care facilities, existing providers, and the George Washington University Hospital to establish a robust system of care for all District residents and in particular, communities east of the Anacostia River.

As previously announced by the Mayor, practitioners, physicians, and academic medicine at the new medical center will be provided by the George Washington University Medical Faculty Associates and the George Washington University School of Medicine and Health Sciences. Childrens National Hospital pediatricians, nurses, and physician assistants will provide infant and pediatric care. Specifically, Childrens National staff will operate the pediatric emergency department and neonatal intensive care unit (NICU).

This generational health care project builds on Mayor Bowsers continued investments in Ward 8.In just the last year, the Mayor opened the new 801 East Mens Shelter and broke ground on the new Whitman-Walker Clinic and opened the Townhomes at St. Elizabeths East. Last year, the hospital design, completed by HOK and McKissack & McKissack, was approved by the United States Commission of Fine Arts and received its Certificate of Need from the State Health Planning and Development Agency.

Social Media:Mayor Bowser Twitter:@MayorBowserMayor Bowser Instagram:@Mayor_BowserMayor Bowser Facebook:facebook.com/MayorMurielBowserMayor Bowser YouTube:https://www.bit.ly/eomvideos

Read the original:
Mayor Bowser and Universal Health Services Announce Plan to Expand Size of Cedar Hill Regional Medical Center, GW Health, Adding a Fourth Patient...

Dan the Man: Meet the manager of OUWB’s Anatomy Lab, medical students’ ‘first patients’ – News at OU

Oakland University William Beaumont School of Medicine students always remember their first patient and since the schools launch, Dan Schlegel has had a key role in those relationships.

The reason?

Schlegel has managed OUWBs Anatomy Lab since its start in 2011.

He is responsible for taking care of the lab and the donors in this context, that primarily means people who made a pre-death decision to donate their respective bodies to science so that medical students can study and truly understand structures within the human body.

Its a unique job that Schlegel says generally elicits one of two reactions.

People are either super interested and ask a lot of questions, he says with a smile. Or they just kind of back away slowly.

Regardless, Schlegel says he never forgets what the job is really all about.

For me, its all about working with the students and faculty to help build future doctors, he says.

Those who work closest with Schlegel say his commitment to the role is evident.

Dan does an exceptional job, says Malli Barremkala, associate professor, Department of Foundational Medical Studies and director of OUWBs Body Donation Program.

Over the years he has been instrumental in the support of the anatomy programs at OUWB, and we affectionately call him Dan the Man.

I was a little tentative

In his managerial role, Schlegel works directly with OUWB faculty to ensure students have what they need when it comes to studying anatomy in the lab. Additionally, he supports Oakland University physical therapy programs, which also use the lab.

His responsibilities not only include moving and preparing donors, but ensuring students have all of the equipment they need, that the entire space is maintained and held to the highest standards of cleanliness, and that all rules are followed. For example, students are prohibited from taking pictures in the lab.

Schlegel says his daily work in the lab is guided by two principles: the important role the donors play in helping students learn, and the need to maintain respect.

Donors essentially donate themselves before deaththey give everything that they are to educate students, he says. We respect donors as patientsjust because they cant hear you or respond doesnt mean we treat them less.

Of course, the big question is: how does one become manager of a medical school anatomy lab?

For Schlegel, it started when he was an undergrad at Oakland University, pursuing a bachelors degree in health sciences.

During that time, in the mid-2000s, Schlegel had his first experience with donors. It was different from the experience that medical students have because the anatomic specimens were prosected (already dissected by more experienced anatomists).

Still, the experience helped build his comfort level of working with body donors. The fact that he has always been science-minded further helped.

As a student, I was a little tentative the first time they pulled out the donors in that first lab classbut I was never really squeamish, he says. I was more interested in learning how things worked.

Soon, Schlegel was helping others learn how things work as a teaching assistant for Mary Bee, Ph.D., associate adjunct associate professor, School of Health Sciences.

When presented with the opportunity to join OUWB in 2011, he jumped at the chance.

It was a month before OUWB welcomed its charter class of 50 students.

Theyre even more comfortable

For the first two classes, OUWBs anatomy lab was in the basement of Oakland Universitys Mathematics and Science Center. Schlegel said the situation was less-than-ideal as the space did not have windows, the loading dock was across the hall, there was lackluster ventilation, and other issues existed.

Among the biggest, he said, was that the donors had to be moved every time there was a class.

All of that changed in 2013, when the lab was relocated to the third floor of Oakland Universitys Hannah Hall following a complete remodeling of the space that now houses the anatomy lab.

The restricted lab now features 37 tables specifically for donors, each equipped with a special ventilation system and computer. The size and the layout of the lab allows students to move freely and not feel crammed into a tiny space. Windows line the walls, creating a bright atmosphere.

Schlegel says his favorite part of the job is seeing the evolution of students with regard to how they approach donors.

At the beginning of the semester, some of the students can be pretty (hesitant), but by the end of the semester they are totally immersed, he says. Then they come back for the second semester and theyre even more comfortable.

Having an OU alum run the lab is beneficial, says Barremkala.

He has knowledge of the OU campus and facilities and he uses this effectively for a well-functioning lab, he says.

Schlegel also goes above and beyond to help keep students on track.

Dan was one of the very few employees that worked in-person throughout the pandemic and played a key role in delivery of the lab component of the AFCP (Anatomical Foundations of Clinical Practice) course, says Barremkala.

Looking ahead, Schlegel says he is excited that OUWB recently started its own body donor program. So far, OUWB has worked with other institutions like University of Toledo to obtain donor bodies, which are then given back to the school at the end of the year for proper cremation and return to the family.

Well have more control over the embalming process, selection criteria of the donors, and direct contact with the families, which makes it a little easier to get necessary medical records, he says. Its really exciting.

For more information, contact Andrew Dietderich, marketing writer, OUWB, at adietderich@oakland.edu.

To request an interview, visit the OUWB Communications & Marketingwebpage.

NOTICE: Except where otherwise noted, all articles are published under aCreative Commons Attribution 3.0 license. You are free to copy, distribute, adapt, transmit, or make commercial use of this work as long as you attribute Oakland University William Beaumont School of Medicine as the original creator and include a link to this article.

Follow OUWB onFacebook,Twitter, andInstagram.

See the article here:
Dan the Man: Meet the manager of OUWB's Anatomy Lab, medical students' 'first patients' - News at OU

UAB freshman pre-med student Shi recognized as a 2022 Presidential Scholar – University of Alabama at Birmingham

Shi, an Honors College and pre-med student at UAB, has been recognized by the President of the United States as a 2022 Presidential Scholar.

University of Alabama at Birmingham freshman James Shi of Vestavia Hills, Alabama, a graduate of the Alabama School of Fine Arts, has been named a 2022 U.S. Presidential Scholar in its 58th class, an achievement directed by Presidential Executive Order.

With only 161 students recognized of more than 5,000 qualifying candidates one man and one woman from each state, the District of Columbia and Puerto Rico, and U.S. families living abroad are selected as scholars by the White House Commission on Presidential Scholars. Scholars are based on their academic success, artistic and technical excellence, essays, school evaluations and transcripts, as well as a demonstrated commitment to community service and leadership.

It was really exciting to be named Alabamas only male Presidential Scholar, Shi said. Its a tremendous honor and something that I am proud to carry.

An accomplished student in high school and involved in his community aspects that Shi attributes to his naming as Alabamas lone male Presidential Scholar Shi joins UAB as an Honors College student with a neuroscience major and a chemistry minor in the College of Arts and Sciences.

Being named a Presidential Scholar is highly competitive and a testament to James character as one of only three recognized students from Alabama, Pam Benoit, Ph.D., UAB senior vice president for Academic Affairs and provost. His recognition as a Presidential Scholar exemplifies the caliber of student and community steward that he is, and were pleased that he has chosen to complete his academic career here at UAB.

In addition, Shi is part of UABs Early Medical School Acceptance Program, with hopes of attending the UAB Marnix E. Heersink School of Medicine to become a neurooncologist in the future. He has immersed himself in basic research working in Rui Zhaos, Ph.D., laboratory in the Department of Biochemistry and Molecular Genetics, as well as currently with Ryan Miller, M.D., Ph.D., in his laboratory in the Division of Neuropathology in the Department of Pathology.

My interest in medicine cancer, specifically stems from childhood; I had a friend pass away from a brain tumor and it inspired me to go into neuroscience, Shi said. Ive conducted research and worked in labs here at UAB already with , which has really affirmed my interest in the neuro-oncology space. Being at UAB and having such close proximity to the medical campus was attractive to me, and I am excited about the opportunities ahead of me as I continue my coursework and collegiate experience as a Blazer.

Read the original here:
UAB freshman pre-med student Shi recognized as a 2022 Presidential Scholar - University of Alabama at Birmingham

Medical students take part in disaster drill simulating mass casualty event on Long Island – CBS News

BETHPAGE, N.Y. - Medical students on Long Island are ready for a potential disaster.

The Zucker School of Medicine put its first-year students through unique training, responding to a mass casualty event.

As CBS2's Carolyn Gusoff reports, these future doctors are also learning to be EMTs.

The screams are simulated, and so is the smoke, but the scenario is all too real: A mass shooting on a train, or derailment. In this drill, medical students are learning just how chaotic and critical the front of the front lines are.

Ninety-nine first-year students with Zucker School of Medicine at Hofstra/Northwell teamed up with the Nassau Fire Academy, who teach what hell can look like.

"It's one thing to talk about it. It's one thing to plan for it, but until it's hands-on, you're not building the muscle memory necessary for this," said Chief Michael Strong of the Nassau County Fire Service Academy.

"This is what we want because in a real situation we are going to have chaos like this, people yelling, screaming, grabbing on to the rescuers," said EMS instructor George Sandas.

The drill teaches future doctors to think and act decisively.

"Definitely a lot to take in. A little stressful, but in a good way, you know. I think it's a great learning experience," said medical student Allison Winter.

Because disaster can strike anywhere: A terrorist attack, a crash, a mass shooting.

"I grew up with school shootings happening very often," said medical student Nefes Prizada. "I was a little shaken, but I was grateful for the opportunity to learn what to do in that situation."

"What they're doing here is rapid assessment, rapid treatment. They're doing a really good job of triaging," said Paul Wilders of the Nassau County Fire Service Academy.

The training is unique for medical students. It is one of the only such programs in the nation, rising out of the ashes of 9/11.

"We decided to bring alive the lessons learned, really items that we thought every physician should know, regardless of specialty, about being involved in a disaster," said Dr. Brad Kaufman, an associate professor at the Zucker School of Medicine.

"This is all about learning to be yourself in an emergency situation," said Zucker School of Medicine Dean Dr. David Battinelli.

Students will finish their first weeks of medical schools as certified EMTs, because disaster is not a matter of if, but when.

Carolyn Gusoff has covered some of the most high profile news stories in the New York City area and is best known as a trusted, tenacious, consistent and caring voice of Long Island's concerns.

Link:
Medical students take part in disaster drill simulating mass casualty event on Long Island - CBS News

ThedaCare and Froedtert & The Medical College of Wisconsin Announce Partnership to Expand Access to the Most Advanced Levels of Care ThedaCare -…

ThedaCare and the Froedtert & the Medical College of Wisconsin (MCW) health network are announcing a partnership that will provide patients with expanded and convenient access to the most advanced levels of specialty care.

The vision of the partnership will elevate care for local communities in Northeast and Central Wisconsin, ensuring patients have access to high-quality, advanced levels of medicine when needed and creating a seamless, integrated connection to pre- and post-care near home.

As part of the partnership, the Froedtert & Medical College of Wisconsin health network will provide progressive medical care to ThedaCare patients for unique specialty services such as heart and lung transplants and advanced heart failure, with ThedaCare providing care locally before and after.

The Froedtert & the Medical College of Wisconsin health network and ThedaCare have a shared commitment to the people of Wisconsin, said Cathy Jacobson, president and CEO of Froedtert Health. Enhancing access to the most advanced levels of specialty care through this new partnership supports our missions to improve the health and well-being of the communities we serve.

The Froedtert & MCW health network will also provide virtual critical care in coordination with ThedaCare providers as part of the partnership. There will be an opportunity to add more specialty services over time based on community need.

Our patients and community members living in Northeast and Central Wisconsin can expect better health outcomes through expanded, convenient access to coordinated, specialty care close to home, said Imran A. Andrabi, MD, FAAFP, ThedaCare President & CEO. Our focus will be on providing seamless care, putting patients and families first, always.

The need for advanced heart and lung care is significant. In 2021, more than 41,000 organ transplants were performed in the United States, an increase of 5.9 percent over 2020, according to preliminary data from United Network for Organ Sharing (UNOS). According to UNOS, in 2021, organizations and transplant hospitals performed a record 3,817 heart transplants across the country. The demand for advanced care continues to grow as 2021 is also the tenth consecutive year where heart transplant numbers have set a new record. Lung cancer is the leading cause of cancer death, making up nearly 25 percent of all cancer deaths, according to the Centers for Disease Control.

The Froedtert & MCW Adult Transplant Center is part of Southeastern Wisconsins only academic health network, a uniquely qualified resource that expands transplant options for patients throughout the state. Its nationally-recognized physicians and surgeons treat patients with a multidisciplinary and collaborative team approach. One of only two lung transplant centers in Wisconsin, the Transplant Center is renowned for care in both pulmonology and lung surgery, according to U.S. News & World Report 2021-2022. The adult organ programs are certified by Medicare and Medicaid, and kidney, liver, heart and lung transplant programs are designated Centers of Excellence by most insurance providers.

According to the American Lung Association, centers that perform lung transplants are located throughout the country, however many people in need of a transplant live a great distance from those locations. This can create additional stress for patients and families who must also find lodging, supplementary financial support, time away from work and more.

This partnership will enable improved outcomes for the most complex patients cared for by our health systems, said Joseph Kerschner, MD, Provost & executive vice president, The Julia A. Uihlein, MA, Dean of the MCW School of Medicine. For example, when a call comes in that an organ has been procured for transplant, the teams must work quickly often within just a few hours to provide the best possible outcomes for the patient. Our new partnership will ensure this seamless care for patients throughout the region.

Through this partnership, transplants can be performed in Froedtert & MCW health network facilities, with the patient returning home for coordinated follow up and supportive care by ThedaCare. Before and following a transplant, patients will have access to providers in their nearby communities to continue coordinated long-term care to maintain their recovery.

The seamless transfer of care between our organizations can truly help patients and families in our region, said Dr. Andrabi. Collaborative care will already be in place, before a persons transplant, and through follow up and ongoing care, close to home, with identified providers from organizations continuing to support the patients health and well-being.

This partnership will further ThedaCares development of a graduate medical education program, which will enhance patient access to medical and specialty services, and help strengthen the future of health care in Northeast and Central Wisconsin.

Physicians will play key leadership roles in this partnership, as it will be governed by a committee comprised of physicians and leaders from the three organizations.

Patients may begin experiencing coordinated care from ThedaCare and the Froedtert & the MCW health network by the end of 2022.

The Froedtert & the Medical College of Wisconsin regional health network is a partnership between Froedtert Health and the Medical College of Wisconsin supporting a shared mission of patient care, innovation, medical research and education. Our health network operates eastern Wisconsins only academic medical center and adult Level I Trauma Center at Froedtert Hospital, Milwaukee, an internationally recognized training and research center engaged in thousands of clinical trials and studies. The Froedtert & MCW health network, which includes 11 hospital locations, more than 2,000 physicians and more than 45 health centers and clinics, draws patients from throughout the Midwest and the nation. In our most recent fiscal year, outpatient visits were nearly 1.5 million, inpatient admissions to our hospitals were 55,085 and visits to our network physicians exceeded 1.1 million. For more information, visit froedtert.com.

For more than 110 years, ThedaCare has been committed to improving the health and well-being of the communities it serves in Northeast and Central Wisconsin. The organization delivers care to more than 600,000 residents in 17 counties and employs approximately 7,000 health care professionals. ThedaCare has 180 points of care, including eight hospitals. As an organization committed to being a leader in Population Health, team members are dedicated to empowering people to live their unique, best lives. ThedaCare also partners with communities to understand needs, finding solutions together, and encouraging health awareness and action. ThedaCare is the first in Wisconsin to be a Mayo Clinic Care Network Member, giving specialists the ability to consult with Mayo Clinic experts on a patients care. ThedaCare is a not-for-profit health system with a level II trauma center, comprehensive cancer treatment, stroke and cardiac programs, as well as primary care.

Related

More:
ThedaCare and Froedtert & The Medical College of Wisconsin Announce Partnership to Expand Access to the Most Advanced Levels of Care ThedaCare -...

Penn Medicine Partners with Philadelphia 76ers To Become Official Healthcare Partner of the Team – NBA.com

MULTI-YEAR PARTNERSHIP BRINGS TOGETHER TWO ICONIC BRANDS WITH SHARED GOAL OF MAKING IMPACT ON HEALTHCARE IN THE PHILADELPHIA COMMUNITY

PHILADELPHIA SEPT. 22, 2022 Today, the Philadelphia 76ers announced a multi-year partnership with Penn Medicine, the areas leading healthcare provider. This unique partnership designates Penn Medicine as the official healthcare, orthopaedic, and hospital partner of the team.

Penn Medicine has established itself as a leading healthcare organization not only in the Greater Philadelphia Area, but in the entire country, said Tad Brown, CEO of the 76ers and Harris Blitzer Entertainment. Were fortunate to partner with such a respected, accomplished team of healthcare professionals and world-class doctors, and look forward to the collective impact we can have in the Philadelphia community. Together, we share a passion for this city and are eager to tip-off this partnership ahead of the 2022-23 season.

Highlights of the 76ers and Penn Medicine partnership include:

As part of this historic partnership, the 76ers and Penn Medicine will also come together on community engagement efforts designed to drive health equity and help reduce disparities. The joint efforts in the community will include:

Like the 76ers, our number-one commitment is to the people of this city and the communities around it, and this partnership allows us to expand our impact on the people we care so much about, in new ways, said Kevin B. Mahoney, chief executive officer of the University of Pennsylvania Health System. Working with the Sixers will greatly strengthen our support for public health and the well-being of our neighborhoods. This is an exciting time for the Sixers as an organization, and were thrilled to be on the same team.

1 / 5Shake Milton wears the 76ers' new shooting shirt featuring the Penn Medicine logo at the team's practice facility.

Penn Medicine is one of the worlds leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nations first medical school) and the University of Pennsylvania Health System, which together form a $8.9 billion enterprise.

The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $546 million awarded in the 2021 fiscal year.

The University of Pennsylvania Health Systems patient care facilities include: the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Centerwhich are recognized as one of the nations top Honor Roll hospitals by U.S. News & World ReportChester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; and Pennsylvania Hospital, the nations first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.

Penn Medicine is powered by a talented and dedicated workforce of more than 44,000 people. The organization also has alliances with top community health systems across both Southeastern Pennsylvania and Southern New Jersey, creating more options for patients no matter where they live.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2020, Penn Medicine provided more than $563 million to benefit our community.

Read this article:
Penn Medicine Partners with Philadelphia 76ers To Become Official Healthcare Partner of the Team - NBA.com

COVID-19 infections increase risk of long-term brain problems Washington University School of Medicine in St. Louis – Washington University School of…

Visit the News Hub

Strokes, seizures, memory and movement disorders among problems that develop in first year after infection

A comprehensive analysis of federal data by researchers at Washington University School of Medicine in St. Louis shows people who have had COVID-19 are at an elevated risk of developing neurological conditions within the first year after infection. Movement disorders, memory problems, strokes and seizures are among the complications.

If youve had COVID-19, it may still be messing with your brain. Those who have been infected with the virus are at increased risk of developing a range of neurological conditions in the first year after the infection, new research shows. Such complications include strokes, cognitive and memory problems, depression, anxiety and migraine headaches, according to a comprehensive analysis of federal health data by researchers at Washington University School of Medicine in St. Louis and the Veterans Affairs St. Louis Health Care system.

Additionally, the post-COVID brain is associated with movement disorders, from tremors and involuntary muscle contractions to epileptic seizures, hearing and vision abnormalities, and balance and coordination difficulties as well as other symptoms similar to what is experienced with Parkinsons disease.

The findings are published Sept. 22 in Nature Medicine.

Our study provides a comprehensive assessment of the long-term neurologic consequences of COVID-19, said senior author Ziyad Al-Aly, MD, a clinical epidemiologist at Washington University. Past studies have examined a narrower set of neurological outcomes, mostly in hospitalized patients. We evaluated 44 brain and other neurologic disorders among both nonhospitalized and hospitalized patients, including those admitted to the intensive care unit. The results show the devastating long-term effects of COVID-19. These are part and parcel of long COVID. The virus is not always as benign as some people think it is.

Overall, COVID-19 has contributed to more than 40 million new cases of neurological disorders worldwide, Al-Aly said.

Other than having a COVID infection, specific risk factors for long-term neurological problems are scarce. Were seeing brain problems in previously healthy individuals and those who have had mild infections, Al-Aly said. It doesnt matter if you are young or old, female or male, or what your race is. It doesnt matter if you smoked or not, or if you had other unhealthy habits or conditions.

Few people in the study were vaccinated for COVID-19 because the vaccines were not yet widely available during the time span of the study, from March 2020 through early January 2021. The data also predates delta, omicron and other COVID variants.

A previous study in Nature Medicine led by Al-Aly found that vaccines slightly reduce by about 20% the risk of long-term brain problems. It is definitely important to get vaccinated but also important to understand that they do not offer complete protection against these long-term neurologic disorders, Al-Aly said.

The researchers analyzed about 14 million de-identified medical records in a database maintained by the U.S. Department of Veterans Affairs, the nations largest integrated health-care system. Patients included all ages, races and sexes.

They created a controlled data set of 154,000 people who had tested positive for COVID-19 sometime from March 1, 2020, through Jan. 15, 2021, and who had survived the first 30 days after infection. Statistical modeling was used to compare neurological outcomes in the COVID-19 data set with two other groups of people not infected with the virus: a control group of more than 5.6 million patients who did not have COVID-19 during the same time frame; and a control group of more than 5.8 million people from March 2018 to December 31, 2019, long before the virus infected and killed millions across the globe.

People who have had COVID-19 are at an elevated risk of developing neurological conditions within the first year after infection, according to a detailed analysis of federal data by researchers at Washington University School of Medicine in St. Louis. Movement disorders, memory problems, strokes and seizures are among the complications.

The researchers examined brain health over a year-long period. Neurological conditions occurred in 7% more people with COVID-19 compared with those who had not been infected with the virus. Extrapolating this percentage based on the number of COVID-19 cases in the U.S., that translates to roughly 6.6 million people who have suffered brain impairments associated with the virus.

Memory problems colloquially called brain fog are one of the most common brain-related, long-COVID symptoms. Compared with those in the control groups, people who contracted the virus were at a 77% increased risk of developing memory problems. These problems resolve in some people but persist in many others, Al-Aly said. At this point, the proportion of people who get better versus those with long-lasting problems is unknown.

Interestingly, the researchers noted an increased risk of Alzheimers disease among those infected with the virus. There were two more cases of Alzheimers per 1,000 people with COVID-19 compared with the control groups. Its unlikely that someone who has had COVID-19 will just get Alzheimers out of the blue, Al-Aly said. Alzheimers takes years to manifest. But what we suspect is happening is that people who have a predisposition to Alzheimers may be pushed over the edge by COVID, meaning theyre on a faster track to develop the disease. Its rare but concerning.

Also compared to the control groups, people who had the virus were 50% more likely to suffer from an ischemic stroke, which strikes when a blood clot or other obstruction blocks an arterys ability to supply blood and oxygen to the brain. Ischemic strokes account for the majority of all strokes, and can lead to difficulty speaking, cognitive confusion, vision problems, the loss of feeling on one side of the body, permanent brain damage, paralysis and death.

There have been several studies by other researchers that have shown, in mice and humans, that SARS-CoV-2 can attack the lining of the blood vessels and then then trigger a stroke or seizure, Al-Aly said. It helps explain how someone with no risk factors could suddenly have a stroke.

Overall, compared to the uninfected, people who had COVID-19 were 80% more likely to suffer from epilepsy or seizures, 43% more likely to develop mental health disorders such as anxiety or depression, 35% more likely to experience mild to severe headaches, and 42% more likely to encounter movement disorders. The latter includes involuntary muscle contractions, tremors and other Parkinsons-like symptoms.

COVID-19 sufferers were also 30% more likely to have eye problems such as blurred vision, dryness and retinal inflammation; and they were 22% more likely to develop hearing abnormalities such as tinnitus, or ringing in the ears.

Our study adds to this growing body of evidence by providing a comprehensive account of the neurologic consequences of COVID-19 one year after infection, Al-Aly said.

Long COVIDs effects on the brain and other systems emphasize the need for governments and health systems to develop policy, and public health and prevention strategies to manage the ongoing pandemic and devise plans for a post-COVID world, Al-Aly said. Given the colossal scale of the pandemic, meeting these challenges requires urgent and coordinated but, so far, absent global, national and regional response strategies, he said.

Ziyad Al-Aly, MD, has lead multiple studies on long COVID as a clinical epidemiologist at Washington University School of Medicine in St. Louis and the Veterans Affairs St. Louis Health Care system. His research has included the devastating effects of the virus on the heart, kidneys and mental health.

Xu E, Xie Y, Al-Aly Z. Long-term Neurologic Outcomes of COVID-19. Nature Medicine. Sept. 22, 2022. DOI: https://doi.org/10.1038/s41591-022-02001-z

This research was funded by the U.S. Department of Veterans Affairs; the American Society of Nephrology; and KidneyCure. The data that support the findings of this study are available from the U.S. Department of Veterans Affairs. VA data are made freely available to researchers behind the VA firewall with an approved VA study protocol.

About Washington University School of Medicine

WashU Medicine is a global leader in academic medicine, including biomedical research, patient care and educational programs with 2,700 faculty. Its National Institutes of Health (NIH) research funding portfolio is the fourth largest among U.S. medical schools, has grown 54% in the last five years, and, together with institutional investment, WashU Medicine commits well over $1 billion annually to basic and clinical research innovation and training. Its faculty practice is consistently within the top five in the country, with more than 1,790 faculty physicians practicing at over 60 locations and who are also the medical staffs of Barnes-Jewish and St. Louis Childrens hospitals of BJC HealthCare. WashU Medicine has a storied history in MD/PhD training, recently dedicated $100 million to scholarships and curriculum renewal for its medical students, and is home to top-notch training programs in every medical subspecialty as well as physical therapy, occupational therapy, and audiology and communications sciences.

Link:
COVID-19 infections increase risk of long-term brain problems Washington University School of Medicine in St. Louis - Washington University School of...

A free medical clinic opened in rural East Texas. Thousands poured in for help. – The Texas Tribune

Sign up for The Brief, our daily newsletter that keeps readers up to speed on the most essential Texas news.

Juanita Franklin was driving through the East Texas town of Gun Barrel City a couple of years ago when she saw a new sign down the road from the Christian Life Center food pantry where she volunteers. It promised something she desperately needed: Healthcare Access for All!

Franklin, whose left leg is amputated below the knee and who has chronic high blood pressure and thyroid problems, is among the 18% of Texans who are trying to survive without health insurance. Thats the highest state rate in the country by far and more than double the national average. The rate is even higher nearly 30% among the 6,400 residents of Gun Barrel City.

The sign Franklin saw that day staked in front of a former office building announced an effort by two local doctors to bring relief to some of those struggling Texans.

Doug Curran and Ted Mettetal have practiced medicine for 80-plus years combined, most of it in a thriving private practice in the town of Athens, about 20 miles east of Gun Barrel City. In 2019, at an age when most physicians are ready to retire, the longtime friends set out on a new venture: opening a safety-net clinic that would treat anyone, regardless of their ability to pay.

Such clinics are urgently needed because low-income Texans have less access to health care than residents of any other state.

Eligibility for Texas Medicaid the federal-state partnership that provides health insurance to low-income Americans is so restrictive that a family of three is denied coverage if it earns more than $4,000 a year. Those who do qualify may not be able to find doctors who accept the public insurance because the states reimbursement rates are so low. A 2017 survey found that a third of Texas doctors refuse to accept new Medicaid patients.

Curran has tried for years to persuade the Republican-dominated state Legislature to address these problems. When he served as president of the Texas Medical Association from 2018 to 2019, he made it his mission to get Gov. Greg Abbotts signature on a bill to expand Medicaid coverage, a position 69% of Texans now support, according to a 2020 poll by the Episcopal Health Foundation. But Texas remains among 12 states that have refused expansion, even though the federal government would pay at least 90% of the cost.

I basically spent a year of my life trying to convince Texas legislators that they really ought to value our people more, they ought to provide better access for all our people, especially our working poor, said Curran, who leans conservative but has grown increasingly progressive. But our state has not had the wisdom of engaging that.

If Texas expanded Medicaid as envisioned in the 2010 Affordable Care Act, a family of three could qualify for health care coverage if it earned as much as $31,000.

In 2019, Curran and Mettetal along with Athens native Glen Robison, who had managed their private practice began planning to close at least a sliver of the health care gap themselves.

The idea was to build a network of safety-net clinics to serve a mostly rural area east of Dallas, beginning with the clinic in Gun Barrel City. Theyd combine the clinics with a medical residency program to bring desperately needed new doctors into the region.

To launch the East Texas Community Clinic, or ETCC, they persuaded two local organizations to put up $200,000 in seed money. For long-term funding they set out to apply to a federal agency, the U.S. Health Resources and Services Administration, which offers millions of dollars in grants and enhanced Medicaid and Medicare reimbursements to qualified clinics in poorly served areas.

In a series of interviews with Public Health Watch over the past 13 months, Curran, Mettetal and Robison laid out what has happened in the three years since they launched their grand plan.

Much of what they had envisioned has gone as expected. The need for the clinics is certainly there. If anything, its greater than they had imagined. And their residency program, a collaboration with the University of Texas Health Science Center in Tyler, has been even more successful than they had hoped.

Where they went wrong, Curran said, was in underestimating how hard it would be to get a good thing done.

They had hoped to receive the federal funding relatively quickly by the end of 2021 because to them the health care needs in Texas seemed so obvious and urgent. But the bureaucracy has moved at a glacial pace.

I thought, were gonna do this thing and everyone will recognize the need and say lets absolutely help you, but thats not what happened, Curran said.

To calm his frustrations, Curran, who is 73, likes to reflect on the story of Roald Amundsen, the Norwegian explorer who led the first successful trek to the South Pole. Amundsen succeeded because he persisted in pushing forward 20 miles each day, Curran points out, no matter how harsh the conditions.

Thats kind of how weve done this, he said.

* * *

The Gun Barrel City clinic opened at 8 a.m. on May 20, 2020. As Curran waited for the first patients to arrive, he wondered for a moment what he had gotten himself into.

Here I am, 70 years old, starting a new adventure, he said. You kind of ask yourself, what in Gods name am I doing?

His friend Mettetal was 69. And Robison, then 45, had left a steady job and taken a pay cut to join them. The plan may have seemed crazily ambitious to an outsider, but the three men had seen firsthand the consequences of people having to forgo care because they couldnt afford it. They felt compelled to help.

Retirement didnt suit the doctors, anyway. They relished the joys and pace of small-town medicine: delivering a baby in the morning, stitching up a wound in the afternoon, making a house call after work.

When youre used to going 90 miles an hour, you kind of go stir crazy, Mettetal said.

Robison had the technical skills to run day-to-day operations and navigate the clinic toward steady, long-term funding. The doctors had state and local connections that could help them patch together start-up funds and resources.

A group of physicians from their former private practice in Athens agreed to buy the 1,900-square-foot Gun Barrel City building and lease it to them. They used an economic-development loan to gut the old accounting office and create four small exam rooms.

The Dallas-based Ginger Murchison Foundation, whose namesake had deep ties to Henderson County, where ETCC is based, and Ardent Health, a privately owned company that operates health care facilities in Texas and other states, donated the $200,000 in seed money. A third funder the East Texas Medical Center Foundation stepped up after Curran drove one of its board members, a neurosurgeon and old friend, to Waco to visit a safety-net clinic similar to what ETCC was hoping to build. So much in life, its not what you know, its who you know, Curran said.

To save money, Curran and Mettetal worked without pay, on alternate days, six days a week. The clinics doors were open 10 hours on weekdays, six hours on Saturdays.

Weve never read anything in the Bible that talks about retirement, said Mettetal, who, like Curran, grew up in rural Arkansas. The two met in medical school at the University of Arkansas, where they were both members of the Baptist Student Union. They still worship together at the First Baptist Church in Athens.

The Gun Barrel City clinic offered all the services that a private family practice would preventive screenings, chronic-disease management, immunizations, lab work, prenatal care, child wellness checkups. They used some of their precious start-up money to bring in a pediatrician, Alice Splinter, two times a week.

But there was one big difference between this clinic and their old practice. Patients paid only what they could afford, even if that meant they couldnt pay anything at all. Everyone was welcome.

Patients rolled in slowly at first, maybe a dozen a day.

But word quickly spread, and within a couple of weeks the clinic was booked. Some people traveled hours for the chance to see a doctor.

It was like instantly, we had a full schedule, we were seeing patients left and right, said Colby Estrada, the front-desk receptionist.

Estrada, 22, had always known that plenty of locals couldnt afford health care. Her own father, a rancher, doesnt have medical insurance. But she was shocked by the number of people who came through the door. It wasnt uncommon for 80 to pass through in a single day.

Many had been forced to delay treatment for so long that their ailments had become more costly and complex to treat.

One woman had postponed surgery for an abdominal tumor because she had lost her job and health insurance. Some people had been living with untreated diabetes. Others were on the cusp of kidney failure. The doctors rarely went a week without seeing someone who lived in a car.

It was mind-blowing, Estrada said. Its just amazing to see us help everybody.

Estradas father, Emilio, now comes to ETCC for care. So does her mother, Debra, who works a mile down the road at the local WIC office, which serves low-income women and children. Debra sends her WIC clients there, too.

Its so great to be able to say that right down the road theres a clinic thats sliding-scale, they dont turn anyone away, she said.

The doctors had always known Texans were suffering because they couldnt afford health care. But seeing the reality of the unmet needs was unsettling.

You delude yourself into thinking its not that bad, Curran said. Its pretty bad.

Juanita Franklin, 58, the woman who had seen the clinics sign on her way to volunteer at church, was among the clinics first patients. She and her husband, Kevin, had spent eight years trying to find consistent care for his prostate cancer.

In 2019, when Kevin became too sick to work, he finally qualified for Social Security disability benefits and Medicare. But when his new benefits were added to their household income, Franklin lost the disability assistance that had made her eligible for Texas Medicaid. Shes been uninsured ever since.

It was very scary, she said. I didnt know what else to do but pray.

Franklin now considers ETCC her medical home.

* * *

While Curran and Mettetal were treating the first patients, Robison was running the business side of the clinic. They couldnt survive on donations. They needed the steady stream of funding that the Health Resources and Services Administration offers clinics deemed federally qualified health centers, or FQHCs.

Becoming an FQHC is such a grueling process that many groups hire consultants to do the paperwork for them. To save money, Robison took on the job himself.

The clinic had to be up and running six months before he could even submit an application. During that period, it had to abide by strict FQHC rules to prove it was worthy of the special designation. It couldnt refuse care to anyone. It had to make its services easily accessible. And most of the people on its board of directors had to be patients at the clinic.

The application also required extensive data to prove that the clinics service area which stretched over three counties and included more than 47,000 low-income residents actually needed an FQHC.

Its easy to understand why theres not one of these on every corner, Mettetal said.

Robisons life took on a new rhythm: Build the clinic by day, then write about it in the application that night. He said it felt a bit like walking across a bridge as it was being built.

In January 2021, Robison submitted the 234-page application.

In just seven months, the Gun Barrel City clinic had tallied roughly 7,000 patient visits, and its benefits were already being felt in the emergency room at a nearby University of Texas outpatient facility, which often serves as a safety net for people without health coverage.

Wes Knight, chief financial officer at UT Health East Texas-Athens, said that during the first year of the COVID-19 pandemic, when the ER would have expected an upturn, uninsured visits dropped about 3 percentage points.

The UT facility saw another benefit: It could refer its uninsured ER patients to Gun Barrel City for follow-up care. Curran and Mettetal think the clinic has saved the local hospital system hundreds of thousands of dollars in uncompensated care.

Robison thought details like these would prove that the clinic deserved FQHC status. People familiar with the process told him hed probably hear back from the Health Resources and Services Administration in about 30 days although he figured it might be a bit longer, given that the nation was in the midst of another COVID-19 surge.

A month ticked by and there was still no word.

In March 2021, Robison sent the Health Resources and Services Administration an email asking about the status of the application.

He got the bad news in a form letter that same day.

Their application had been denied because it hadnt proved they were eligible for FQHC status. The letter didnt specify what needed to be fixed, but suggested that they apply again. Robison would have to start from scratch.

But they never considered giving up. Too many people already depended on ETCC to let it fail. In fact, they were getting ready to open a second clinic, this one in Athens. They needed the space to serve their growing list of patients and to train their first four family-medicine residents, who would be arriving that summer.

I figured it wouldnt be the last time wed get rejected, Curran said.

Curran and Mettetal were accustomed to the ups and downs that come with big, complicated projects. In 2010, Mettetal had founded another nonprofit, Hope Springs Water, which drills clean water wells around the world. Curran owns and helps work the ranch where he lives with his wife, Sandy, and tends more than 250 head of cattle. Both Curran and Mettetal helped start their former private practice in Athens.

They have some of their best ideas including ETCC and Hope Springs Water during their ritual, early-morning walks on a quiet road that runs past Currans ranch and the small cemetery where he has plots for himself and his wife.

But getting the clinics on stable footing was turning out to be much more difficult than they had anticipated.

Their three core donors had committed to keep them afloat until they got through the FQHC application process, but they couldnt depend on charity forever. If they didnt qualify as an official FQHC, their plan would be unsustainable in the long term.

* * *

They opened the Athens clinic in June 2021, a couple of months after their FQHC application was rejected. It sits in the center of Athens medical district, next door to the 127-bed University of Texas Health hospital.

You put it right in the middle of all the health care services so that (patients) realize they get the same care that everybody else gets, Curran said.

Ardent Health, one of their primary funders, owned the medical plaza and donated the space, which had just been vacated. It was a bit of luck kind of a God thing, if you will, Robison said.

The 7,000-square-foot facility was more than three times as big as the Gun Barrel City clinic, and furnishing it on a tight budget was no easy task. The previous practice had left behind some exam beds and desks, but other than that, the rooms were bare.

Robison searched everywhere for good deals. He bought an 18-foot conference table and a hutch for $400 from an attorney who was closing her office in Houston, nearly 200 miles away. He found 14 matching upholstered chairs for the waiting room $86 for the lot from a seller in Cedar Hill, 100 miles to the northwest. He roped the seats to the bed of his truck and drove them home.

I looked like Jed Clampett, said Robison, who keeps a sign on his desk that reminds him to keep hustlin.

Appointments filled up fast in Athens, just as they had in Gun Barrel City. By the end of 2021, the two clinics had logged about 15,000 patient visits and had become local points of pride.

Gary Reaves, who owns a plant nursery in the nearby town of Malakoff, sometimes dropped by with lunch for the front-desk staff. His home shares a fence line with Currans ranch.

Athens is a very tight-knit town, Reaves said. And a lot of it is because of people like Dr. Curran.

Reaves has been Currans patient most of his life, first at Currans private practice and now at ETCC. Ive been blessed that I can afford it, Reaves said. But theres a lot of people that cannot.

Reaves, 67, was a drummer in his high school marching band and remembers seeing a young Curran on the sidelines during football games, checking players for injuries. Years later, when Reaves dad was diagnosed with cancer, Curran cared for him until he died. When Reaves brother passed away last year, Curran stopped by to check on his grieving patient, friend and neighbor.

* * *

In many ways, ETCC was expanding exactly as Curran, Mettetal and Robison had hoped it would. In just over a year, theyd opened two clinics, hired three more doctors, seen thousands of patients and launched a successful residency program.

But financially, they often lived month to month. Whenever their bank accounts got perilously low, they went back to their donors with detailed progress reports and requests for more money.

Robison was rewriting the FQHC application with help from the Texas Association of Community Health Centers. He managed the clinics by day and worked evenings and weekends on the application. He said it was the hardest thing hed ever done, including his four years in the Air Force.

It costs $80,000 to $100,000 a month to keep the clinics running. Their three donors fund about 75% of the operation, because about 70% of their patients either have no insurance, inadequate coverage or state Medicaid coverage, which in Texas comes with very low reimbursement rates.

The state typically pays ETCC about $28 for seeing a Medicaid patient. If it provides that same service to a privately insured patient, it can receive as much as $90.

While Robison wrestled with the FQHC application, it seemed the clinics might get a one-time shot of money from the state.

The Texas Legislature was divvying up $16 billion in federal COVID-19 relief money, and one idea was to use $200 million of it to reboot an incubator program the state had once offered to clinics that were trying to become FQHCs.

Curran traveled to Austin to lobby for the provision.

[It] didnt seem excessive in light of the access-to-care issues that Texas has, he said. Not only was ETCC providing affordable care to thousands of uninsured Texans, it was also training young doctors who might end up staying in the rural region for good.

The Legislature passed the bill in October 2021, but it included $20 million, not $200 million, for the incubator program. Curran was still pleased. He assumed ETCC would be eligible for a big chunk of that money. They needed it to hire 10 more staff members, including another physician, medical assistants, a social worker and two full-time billers to negotiate with insurance companies, so they could capture as much revenue as possible.

But six months after the governor signed the spending bill, the Texas Department of State Health Services still hadnt opened the application process. An agency spokesperson told Public Health Watch in May it was in the process of hiring the program staff to begin the program.

Meanwhile, ETCC was close to running out of money again.

Glen and I just looked and were down to our last $50,000, Curran said. So, here we go again, were out of money. Its just such a pain, you know. Its just very frustrating to have to do this when you know theyre sitting on $20 million.

In a stroke of good timing, the Health Resources and Services Administration reimbursed ETCC $130,000 for uncompensated COVID-19 care the clinics had provided. It would help cover their costs for a couple of more months.

Robison had submitted their new application for FQHC status in March, and a reviewer had already been in touch, asking for a few clarifications. That was a good sign. But there was still no word about a site visit, the critical next step.

Curran and Robison went back to their donors. They got another $200,000 early this summer.

* * *

Visit link:
A free medical clinic opened in rural East Texas. Thousands poured in for help. - The Texas Tribune

Celebrating Hispanic Heritage: UConn Health Pulmonologist Dr. Mario Perez – UConn Today – University of Connecticut

Dr. Mario Perez leads medical residents and nurses on rounds on a critical care floor at UConn John Dempsey Hospital (Tina Encarnacion/UConn Health photo).

UConn Today sat down with UConn Health Pulmonologist Dr. Mario Perez, assistant professor of medicine in Pulmonary, Critical Care and Sleep Medicine at UConn School of Medicine, to find out what his Hispanic heritage really means to him, how it has influenced his health care career, and those he cares for from diverse backgrounds at UConn Health.

What does your Hispanic heritage mean to you?Hispanic Heritage means feeling proud and honored to belong to a community that is willing to serve others, some through military service, church, or just plain old hard work. Also, it means pride in being able to communicate in another language and maintain traditions associated with family and community while helping this country to grow and prosper.

Who inspired you to enter medical school and become a doctor?I always enjoyed science and trying to help people. I also was privileged to have an uncle who worked as pediatrician in the rural town where I was born and raised. He allowed me in his office to observe his work many times. Later on in life my brother decided to attend medical school and I was always very curious to explore his textbooks. At the beginning I was fascinated by the pathology pictures shown in his dermatology books, and later on hearing his excitement about human physiology sparked my interest in medicine and excitement to learn more.

How does your connection to the Hispanic community influence your patient care?Because of my heritage I am available to serve some members of our community in their own language and perhaps with a deeper understanding of their needs. At the same time I make an extra effort to be a good role model for others in the community.

As a provider, whats your major focus when caring for those in the Hispanic community?My focus has always been providing the best care I can independently of whom I am serving. Since the prevalence of asthma among the Hispanic population in the State of Connecticut is higher, particularly among Puerto Ricans, I had focused my services on that condition that affects the respiratory system and in particular the airways. Therefore, I tried to provide education for my patients on the dangers of some environmental exposures, tobacco, recreational substance and alcohol. I also encourage them to seek all preventive care, and particularly immunizations to prevent or decrease the morbidity of diseases such as COVID-19 and the flu.

Anything you want to share with the Hispanic community or those working in the health care field?I would like to take the opportunity to thank the Hispanic community that has trusted us with their care, and the UConn Health for fostering an environment of inclusiveness.

Read the rest here:
Celebrating Hispanic Heritage: UConn Health Pulmonologist Dr. Mario Perez - UConn Today - University of Connecticut

Deputy Pro Vice-Chancellor and Dean of the Medical School job with UNIVERSITY OF EXETER | 310002 – Times Higher Education

Company: University of ExeterJob title: Deputy Pro Vice-Chancellor and Dean of the Medical SchoolJob reference: WXRKClosing date: Monday 10th October 2022

The University of Exeter combines world-class research with excellent student satisfaction, from our campuses in the South West of England, in Exeter and Cornwall. We are one of the very few universities to be both a member of the Russell Group and have a Gold award from the Teaching Excellence Framework (TEF), evidence of our established international reputation for excellence in both research and teaching. Our success is built on a strong partnership with our 30,000 students from 150 countries - and a clear focus on high performance. Based on the vibrant St Lukes Campus, the University of Exeter Medical School is critical part of the Universitys Faculty of Health and Life Sciences, and enjoys a world-leading reputation in several areas of research. The Medical School has three departments and is home to 500 staff and almost 3,000 students.

We are now seeking to appoint a new Deputy Pro Vice-Chancellor and Dean of the Medical School. The School has contributed to the overall success of the institution and this role will play a pivotal part in the continued growth of the School and its academic activity. Building on an outstanding reputation for research and education, the Dean will be responsible for the strategic development of the School through the effective leadership of staff and research activity in alignment with Exeters 2030 strategic plan. As a Deputy PVC, the Dean will contribute to the development of wider Faculty and University strategy.

Candidates will have a demonstrable ability to lead a department of appropriate scale within a field of science relevant to the medical school. A track record of leading successful growth across both research and teaching activity within in a high performing context will be key. The appointed candidate will bring a collaborative and inclusive management style, an ability to develop partnerships with external stakeholders ideally with but not limited to the NHS and a capacity to lead through influence alongside efficient and effective resource management.

The University of Exeter is committed to excellence in equality, diversity and inclusion in all our activities. Whilst all applicants will be judged on merit alone, we particularly welcome applications from groups currently underrepresented within our working community. The University of Exeter is committed to equality, diversity, and inclusion in all our activities, and we invite candidates from under-represented groups to consider applying for this opportunity.

Saxton Bampfylde Ltd is acting as an employment agency advisor to the University of Exeter on this appointment. For further information about the role, including details about how to apply, please visit http://www.saxbam.com/appointments using reference WXRK. Alternatively, telephone +44 (0)20 7227 0880 (during office hours). Applications should be received by noon on Monday 10th October 2022.

View post:
Deputy Pro Vice-Chancellor and Dean of the Medical School job with UNIVERSITY OF EXETER | 310002 - Times Higher Education

$42 million renovation of University of Michigan medical research unit proposed – MLive.com

ANN ARBOR, MI - A proposed $42 million renovation and repurposing of two University of Michigan Medical Science wings will go before the universitys Board of Regents on Thursday, Sept. 22.

The project would renovate about 60,000 square feet of space across three levels of UMs Medical Science Unit I building for the Medical Schools Computational Medicine and Bioinformatics department and several other Medical School units.

The proposed project would convert obsolete wet lab research space into an efficient and collaborative dry and computational research environment, according to the regents action request.

The project also would support UMs carbon-neutrality goal through interior and exterior design and construction features, including new energy-efficient HVAC equipment, lighting and control systems. Renovations also would include thermally insulated and triple-glazed windows, maximum insulation of roof and exterior walls and include new electric power and telecommunication systems.

Deferred maintenance is addressed in both wings of the project, including heating, ventilation, air conditioning, electrical, life safety system upgrades and providing accessibility and new finishes throughout.

The Medical Science Unit I building was originally constructed in 1958 and contains nearly 300,000 gross square feet of administrative and wet lab research space. Funding for the project would be provided from Medical School resources, the action request notes.

If approved, the architectural firm SmithGroup will design the project. The project is expected to provide an average of 37 on-site construction jobs. Construction is scheduled to be completed in the fall of 2025, pending approval.

READ MORE:

Incoming University of Michigan president arrives for first tailgate ahead of football game

University of Michigan finalizes $490M settlement with Anderson abuse survivors

University of Michigan reports record $1.7B in research spending in 2022

Read the original post:
$42 million renovation of University of Michigan medical research unit proposed - MLive.com

The Betty Bubble: A Week at the Hazelden Betty Ford Addiction Treatment Center – Diverse: Issues in Higher Education

I spent a week at the Hazelden Betty Ford Addiction Treatment Center in Rancho Mirage, California. No, not as a patient, but as a member of the Summer Institute for Medical Students Program (SIMS). Heres what I learned:

Hazelden Betty Ford is the nations largest nonprofit addiction treatment center and their goal is to address substance misuse utilizing the bio-psycho-social model of care and 12 step programs. Patients are provided mental health resources including cognitive behavioral therapy, dialectical behavioral therapy, anger management, group therapy, and more. Patients are encouraged to participate in meditation, yoga, and are even given a dietician and a personal trainer to improve their overall health and wellness. Hazelden Betty Ford offers in-patient and intensive outpatient treatment as well as family and childrens programs for the loved ones of those with substance use disorder. Their motto is If not us, then who?Dr. Brittany Ladson

Our week long experience was funded by The Betty Ford Foundation whose goal is to raise awareness, stimulate interest, and sensitize professionals to the process of recovery for substance use disorders and their family members. The SIMS program is unique in that, instead of participation in a classroom setting, students learn by integration into the daily life of the patients. It has long been said the best way to help those not addicted understand the recovery process is to let them see it happen and this program did just that.

We were 15 allopathic and osteopathic medical students from 15 different universities all out in Palm Desert to learn more about the disease of addiction. Many of the students had personal or family histories of substance use disorder, while others exposures were from drunk drivers taking the lives of their loved ones. For me personally, my exposure was through research I have been conducting in the understanding of vaping and opiate misuse disorder in high school students and an additional project studying EM residents Naloxone rescue kit prescription habits to patients who have overdosed. I had imagined participating in this week would help me learn what more I can do for my future patients, but as the week progressed, I saw myself aligning more with the patients themselves.

At the beginning of the week, it was clear that the medical students were seen as outsiders looking in during the patients small group therapy. Many of the patients expressed they felt like lab rats while we listened to their stories without actually experiencing addiction ourselves. As the week progressed, patients and students began fraternizing at meal times and in the hallway in between sessions. It was astonishing how fast the patients went from feeling like strangers to people we knew for a lifetime. It was like learning about a patient by looking through a keyhole- having a short period of time to understand all the things they think about and have experienced. At the end of the week, I didnt feel like I was leaving a small group of four patients in recovery, I felt like I was leaving a creative artist, an intelligent future RN, a strong businesswoman, and a caring mother. It truly shows you that addiction is ubiquitous. It is just like gravity, it is all around us. Addiction is an equal opportunity disease.

Our experience in group therapy was becoming a shared experience. I was learning to treat the patient, not just the disease. Patients in rehab are so generous; they really taught us so much and answered so many of our questions better than any textbook could. Doctors spend a lot of time with patients during their lifetime, but very rarely in this capacity. The experience was transformative for the patients as well. Many times patients expressed that they have felt that doctors have not done anything for them in the past. Some patients also expressed hatred of rehab centers because they see it as doctors making money off of their addiction and then sending them off into the world to relapse and present back to rehab. Having future physicians in the room pledging to be a force of change for the future of addiction medicine helped change their perspectives. Patients will see doctors differently and doctors will see their patients differently because of this experience.

Further, the most commonly stated wish expressed by the patients during the week was to take care of ourselves. They all understand how hard it is to complete medical school and work as a physician for the rest of our lives. It is too easy to chase prestige and work yourself to exhaustion. Many patients expressed a similar reason for ending up with a substance use disorder and they didnt want to see that for the next generation of working professionals. The patient whose words most resonated with me on this subject was an emergency medicine physician in treatment for opiate use disorder. He knows better than anyone what the challenging world of medicine can do to a person. He reminded me that my life comes before my career no matter what. All it takes is one left step or one right step for you to become a patient at Hazelden Betty Ford.

As many of the patients describe during their experience at Hazelden Betty Ford, you can feel like you are in a bubble, shielded from the temptations of the outside world. Patients lovingly refer to this as the Betty Bubble. Patients all express concern with being able to apply what they have learned at the center to their real life situations. I, too, have been in the Betty Bubble during the week. I have learned so much but what if I cannot apply it to my real life situations in my residency program, my hospital system, and beyond? Then was going to rehab really worth it?

As a newly matched emergency medicine resident, I resonated with so much during the week. The emergency department is the place where you will see patients with substance use disorder in their most chaotic state. These patients may also be labeled frequent flyers. A patient raised an excellent point that emergency department doctors and nurses will become curious when a patient with a substance use disorder stops presenting to the ER. Its rare they assume the patient is in recovery; instead, they would assume they overdosed and died. However, that patients spot in the emergency department will surely be replaced by another member of the community experiencing addiction and the cycle of judgement by healthcare staff continues. Instead of applying derogatory terms to patients and making light of their addiction, we can be a force of good in their life. As a future emergency medicine physician, I have the power to connect patients to local resources, provide Naloxone rescue kits, and educate family members accompanying the patient on what it means to have addiction. Hospitalizations are a time when patients most likely evaluate their lives and health and if we can offer some wisdom during this time we could help change outcomes. Addiction medicine is truly preventative medicine- it prevents cirrhotic and steatohepatic disease, blood borne illnesses, necrotizing fasciitis, and so much more. We must not undermine the impact we can make in these critical moments.

Moreover, I reflected on the volume of patients seen in the emergency department who experience addiction (whether it is their chief complaint or a long term repercussion). A profound amount of patients experience substance use disorder, including many communities where they make up the majority of ED patients. However, we spend a disproportionate amount of time, education, and health care dollars on learning and treating other conditions. There are so many ways the health care system can better serve patients. Ways we can do this is ensuring that an addiction medicine consult service is available in every hospital. We must also understand the intersectionality of other addictions, most prominently food and nicotine addiction. Addiction is a disease that responds to treatment. We must offer services to all patients no matter how many times it has taken them to accept help. Whos to say that attempt number 30 isnt the one that will finally work? In the ER, we see a snapshot of ones addiction but it is important to remember their entire story and that we can change their ending.

In addition to what can be accomplished in the hospital, there is so much we can do at the medical school level to improve outcomes for patients with substance use disorder. I would like to see medical schools require students to attend in alcoholic or narcotics anonymous meetings. Its one thing to connect a patient with their local AA group, but it is another to share with them what they can expect to experience. And, most importantly, attending an AA or NA meeting shows solidarity in the fight against addiction. I also solidly believe in the power of the experiential learning model. The SIMS program provides the opportunity to learn what rehab centers really look like, what programming is offered, and how it is implemented. Rehab is more than yoga, meditation, and therapy. There are didactic sessions, community fellowship, and so much homework in completing the 12 steps. Rehab is truly two experts coming to the table and treating a disease. The patient is an expert on themselves and the therapist is an expert in counseling. If a patient is apprehensive about attending rehab, being able to share your personal experiences might have profound persuasion.

We also received camel pins just like patients do on their first day in rehab. In AA, camel pins represent how a camel picks up its load at the beginning of the day, holds its head high, stays dry the entire day, and then goes to its knees at the end of the 24 hour period. The same concept applies to sobriety in that you can avoid alcohol and other substances for a 24 hour period. You too can stay dry for a 24 hour period. Sobriety happens one day at a time. Just like many healthcare professionals wear pins to show their solidarity with Black Lives Matter and the LGBTQ+ community, wearing a camel pin can show solidarity with those experiencing addiction. For patients who do not recognize the significance of the camel, it will be a great conversation starter and will help spread the message that recovery is possible. I plan to wear my camel pin through residency and beyond to show support for those struggling in the community I am serving.

At the end of the week, while leaving the center, I couldnt help but notice the profound physical and architectural barriers that keep the rehab center away from public eyes. The 12 feet tall shrubs, security officers, and gates at the front all create privacy in a way that is more profound than any other medical facility type. The Eisenhower Health Center shares the same parking lot as Hazelden Betty Ford but they do not have more than palm trees in their parking lot. Of course HIPPA applies in all medical settings, but there is a deeper reason for Hazelden Betty Fords privacy. There is a very different perception for patients walking into addiction treatment centers verses a cardiology office. The implications it can have on your career and your perception in society can be overwhelming. However, you truly never know who is experiencing addiction and stereotypes will never apply accurately. I understood this best when I learned that nearly all the counselors and medical staff who work at Hazelden Betty Ford are in long term recovery themselves.

After our final day in the program, myself and the other medical students decided to explore the city of Palm Springs and enjoy fellowship among each other. Even this celebratory part of the week had deep implications for me. If you practice addiction medicine, should you feel guilty for having an alcoholic beverage when you are off the clock? When I asked this question to one of the addiction medicine fellows, he replied, The same concept applies if you work with diabetics and have dessert after work. Or if you work with heart attack patients and then have a salty dinner. For someone in recovery, 1 drink is too much and 100 drinks is never enough. I believe doctors have an obligation to their patients to lead by example but must also remember to appreciate that we do not have the disease of addiction.

During this week, my world view changed and now it is my job to take what I have learned and change the world. The SIMS program builds an army. We will be a ripple in the water of addiction medicine. We will help keep patients stay alive long enough to get the relief they are looking for. We will love patients until they can love themselves. SIMS helped complete my education. We have so much textbook education, but now we have the stories of the patients behind it. We learned to listen, not to respond, but to truly hear our patients. We stopped thinking with our heads and started thinking with our hearts. The opposite of addiction is not recovery, it is connection.

On someones first year anniversary of recovery in AA, all meeting attendees sing Happy Birthday to their sobriety. One year from now, I will be celebrating the anniversary of my attendance in the SIMS program and just like in AA, I will be celebrating by singing Happy Birthday. I hope to be reflecting on all the good I was able to do, all the patients I was able to help, and excited for all the great things I have planned to help fight addiction.

Here is the original post:
The Betty Bubble: A Week at the Hazelden Betty Ford Addiction Treatment Center - Diverse: Issues in Higher Education

ROTC cadets gain transformative experiences around the world – Ohio University

Eight Ohio University senior Army ROTC cadets scattered around the world over the summer for Cadet Troop Leader Training and Project GO opportunities.

Each year, Army ROTC cadets are eligible for competitive training opportunities that expose them to careers that match their academic and personal interests. These opportunities provide unique three- to four-week experiences where cadets serve in lieutenant-level leadership positions in active-duty units.

The experience our cadets gain is invaluable and allows them to observe other leadership styles and develop their own leadership skills, said Troy Lovely, who leads the Army ROTC at Ohio University. I am always excited to hear their stories and see the passion ignited for the leadership profession they are about to embark on.

Carissa Nickell, a psychology major in the College of Arts and Sciences, served in Fort Stewart, Ga., as an Army Medical Department intern at Winn Army Community Hospital, a small hospital for active-duty military personnel, their dependents, and military retirees. She completed rotations in pediatrics, physical therapy, occupational therapy, labor and delivery, and the postpartum mother-baby unit. Nickell learned how to draw patient labs, drew blood, learned how to read and interpret all labor and delivery monitors, and learned how to assist in natural deliveries.

There was a culture of respect and it was really learning-oriented. All of the nurses and providers there were really enthusiastic about getting us that hands-on experience that you literally cannot get as a nursing student; you cant get that anywhere else, Nickell said. They were really helpful in making sure we were learning and doing rotations in the hospital that would kind of help us figure out what we wanted to pursue post undergrad.

Nickell said the highlight of her experience was being in the labor and delivery and postpartum units. Nickell participated in more than 10 deliveries, scrubbed in on a Cesarean section, and got to hold newborns and take their vitals. She connected with other cadets from around the nation and learned from nurses and providers with extensive military and civilian experience. This experience led Nickell to realize her passion for nursing, specifically for labor and delivery and midwifery. She is now planning to pursue a masters degree in nursing to become a Certified Nurse Midwife/Certified Nurse Practitioner.

Richard Danylo, a chemical engineering and computer sciences major in the Russ College of Engineering and Technolgoy, travelled to Germany. He plans to matriculate into medical school next fall, so he shadowed doctors to better understand the Army physician lifestyle. He met with around 40 doctors and went to 10 different clinics to explore several medical specialties. He scrubbed into more than 10 surgeries, which was a unique experience for an undergraduate student. The Army doctors gave him advice about applying to medical school and let him use their medical libraries to conduct research.

Danylo described getting to scrub in on a shoulder repair surgery.

The doctor had me retracting skinand this was probably like a two-hour surgery. I didnt know it but apparently, its a rite of passage that a lot of people, when they start to go through surgery rotations in medical school, (they) get to the point where they might pass out, they start sweating because they get tired from doing grunt work like that, Danylo said. One of the other physicians in the room saw me really sweating but I made sure I didnt say anything. Afterwards they had a congratulations for me because I was now inducted into surgery.

This experience made Danylo consider going into surgical oncology and confirmed that medicine is the career he wants to pursue. Danylo said he appreciated all the mentors he met in Germany, the mentors he has here at OHIO who helped him get the internship, and the University for facilitating the ROTC program.

Nate Frimel, a history and political science major in the College of Arts and Sciences, was also in Germany this summer, after completing his required training at Fort Knox, Kentucky. He was attached to Charlie Company in the 1-214 General Support Aviation Battalion. In Army Aviation, the Charlie Company of every battalion is the medical evacuation (MEDEVAC) detachment, so the pilots focused on rescue missions. Frimel learned about topics like helicopter aerodynamics and the most efficient way to manage Army personnel.

I was able to establish effective relationships with almost everyone there, Frimel said. From the pilots to the mechanics, the experience showed me what being an effective Army officer looked like. Also, I got to fly in a Blackhawk, which was, by far, one of the coolest experiences of my life.

Luke Hinesley, a management information systems major, also went to Fort Knox, Kentucky, then Germany. He shadowed a lieutenant in the Second Cavalry Regiment and got to learn what officers in different Army branches do. Hinesley hopes to be a platoon leader after commissioning as an Army officer. His favorite experience this summer was getting to blow up 30 pounds of C-4.

The other OHIO ROTC cadets who completed internships and training this summer were Will Dunning, who travelled to South Korea for Air Defense Artillery training; Chance King, who helped with explosive exercises with an infantry/mortar platoon in Kentucky; Collin Brown, who learned how to parachute out of a helicopter as part of Airborne training in Georgia; and Ander Wehner, who participated in Project Go, a cultural and language immersion program in Taiwan.

Go here to see the original:
ROTC cadets gain transformative experiences around the world - Ohio University

MUSC to help with psychological first aid in Puerto Rico in Fiona’s aftermath – Medical University of South Carolina

On Monday, psychologists from the Medical University of South Carolina will hold a training session at a university in Puerto Rico via Zoom. Theyll coach participants on how to offer psychological first aid in the aftermath of Hurricane Fiona on an island still recovering from the devastation of Hurricane Marias 2017 strike.

Rosaura Orengo-Aguayo, Ph.D., an associate professor in MUSCs Department of Psychiatry and Behavioral Sciences, grew up in Puerto Rico and will lead the training session. She knows firsthand what its like to recover from a big storm in the U.S. territory, which gets walloped every seven or eight years. Shes also getting reports about Fionas impact from family members on the island.

My mom and my sister and my brother are all fine, physically. Their homes are intact. None of them have power, and water just returned today. But everyone there knows a direct family member or friend who had flooding damage or losses.

Some of those people are still scarred by the effects of Hurricane Maria, the most catastrophic storm to hit Puerto Rico in decades. It led to around3,000 deathsby some estimates and took out a lot of the islands infrastructure, including the electrical system.

Mondays training session is a continuation of MUSCs involvement with Puerto Rico, a connection that began after Maria. In 2017, a friend in Puerto Rico told Orengo-Aguayo the education secretary was looking for people who could come up with a comprehensive plan to help teachers and students deal with Marias aftermath. Schools were closed, utilities were out and loved ones were leaving.

For Orengo-Aguayo, it was a no-brainer. I think as professionals, we sometimes leave the personal out of the professional life. But in our team, we're the opposite. Im Puerto Rican, so that will forever be my home.

She and her colleagues used a grant they already had from the Substance Abuse and Mental Health Services Administration to train Puerto Rican teachers in how to take care of their own mental health while also caring for the kids who weathered the storm.

Since that teams first visit in October of 2017, the MUSC psychologists have been back multiple times to continue their work. In the last four years, we trained Puerto Rican providers to dotrauma-focused cognitive behavioral therapy, Orengo-Aguayo said.

They also conductedone of the largest post-disaster screening projects in U.S. history. It found most of the so-called Maria generation kids saw houses damaged on an island roughly the size of Connecticut, about half had damage to their own home, almost 58% had a friend or family member leave Puerto Rico, about a third had to deal with a lack of food or water and more than 15% still didnt have electricity several months after the September 2017 storm.

Clearly, Maria was life-altering for the island and its people. The MUSC team knew its work needed to continue. So Orengo-Aguayo and her colleagues recently got five more years of SAMSHA funding for their work in Puerto Rico.

She and another bilingual MUSC psychologist, Regan Stewart, Ph.D., had already scheduled another trip to Puerto Rico before Fiona. October 13th through the 25th, this trip was very much to meet with our partners in Puerto Rico. We're going to have a team retreat to discuss our goals and next steps, she said.

We also have four days going to a small island off the coast of Puerto Rico. That's a municipality called Culebra. And this island does not have a single mental health professional. So we're partnering with grassroots organizations to start the first ever telehealth program there so kids can get access to psychologists in the mainland, in Puerto Rico, in the island. So that's part of our trip as well.

Theyll also meet with experts at the largest community mental health center in Puerto Rico to follow up on needs and next steps. But Orengo-Aguayo said their work probably wont stop there.

I suspect we'll be doing some relief work as well. It'll likely involve meeting with leaders and stakeholders of agencies to assess, How do we support our staff? How do we support our students going back to school?

Familiar questions for a woman working to help the island she loves develop the mental health services it needs. My mission still as a clinical psychologist is that future clinical psychologists don't need to leave the island to get the best training, the best care. So for me, until my career's over, it will be about capacity building so that Puerto Ricans stay in Puerto Rico.

Continued here:
MUSC to help with psychological first aid in Puerto Rico in Fiona's aftermath - Medical University of South Carolina