Author Archives: Danzig

Expediting IND applications with drug master files – BioPharma Dive

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Completing an investigational new drug (IND) application can be a long and tedious process, one known to bog down timelines and frustrate sponsors looking to take their cell or gene therapy (CGT) to the clinic. In a tight race to trials, program sponsors look for efficiencies from bench to bedside.

Using off-the-shelf materialssuch as plasmid DNA products and CRISPR-associated nucleases is one way to potentially speed things up particularly if they come with a drug master file, or DMF.

Drug master files are reference packages that report to the FDA information about the processes involved in new drug products. Theyre not FDA-required nor approved nor denied but they can help supplement INDs and other applications as a way to cross-reference new processes with pre-filed submissions.

And as a concept, DMFs arent new. Download the DMF list and youll see tens of thousands of submissions, some dating to 1939. Theyve always been used to support various materials, even ibuprofen and acetaminophen. But as normalized as theyve become, DMFs are still novel among CGTs, which only recently began using off-the-shelf materials that would benefit from a DMF.

With the growing standardization of cell and gene therapies, interest has emerged in DMFs as a tool to expedite the path to clinical trials. If you use an off-the-shelf reagent that has a DMF, the application links to that preexisting file without the filer having to provide redundant information.

As more off-the-shelf materials such as plasmids become available for cell and gene therapies, suppliers are submitting DMFs for those products as a benefit to customers. Doing so gives researchers a dual offering: They can not only access standardized materials at GMP-grade with the cost and time savings that come with that but they can also cross-reference their INDs to the already prepared DMF.

Two examples of these DMF-ready products are Aldevrons SpyFi Cas9 nuclease and pALD-X80 helper plasmid, each available from research grade to GMP. When new cell and gene therapy products use these materials, users automatically get the benefit of a pre-filed DMF that references Aldevrons manufacturing processes involved in making them.

The reason IND submissions have long embraced DMFs is the same reason DMFs are likely to rapidly expand among CGT applications in the months and years ahead: Theyre not just efficient in saving time, but theyre also potentially more comprehensive with less of a risk of missed information.

If you use the SpyFi Cas9 nuclease, for example, or others offered from Aldevron, you can skip the drug substance part for the Cas9 product when filing the IND because Aldevron has already prepared the DMF.

And when linking to the DMF, the FDA gets complete access to manufacturing information without the filer having to do so. This avoids overlooking information the FDA might need, which can delay application review.

Moreover, translational medicine organizations may find particular value in DMF-ready products because they overcome resource barriers inherent to hospitals and academic institutions. Unlike big pharma or biotech companies, many such organizations may not have easy access to field experts. Turning to DMFs gives academic outfits the economies of scale they might not get otherwise.

By 2025 thats just two years away the FDA expects to approve up to 20 cell and gene therapy products per year. With all that IND activity in a crowded market, sponsors will need any differentiating efficiency they can get along the pathway to clinical trials and beyond.

By taking advantage of pre-filed DMFs, researchers benefit from the value, time savings and reduced complexities of having someone else do the heavy lifting for key components of the final drug product. After all, this concept isnt new in drug development. However, the science in this so-called new frontier of medicine is. As it becomes more standardized, everyone wins including future patients.

Looking for other ways to standardize processes and accelerate your path to market? Stay tuned for Aldevrons next post, where well explore how plasmid backbones can simplify development logistics and reach your goals faster.

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Expediting IND applications with drug master files - BioPharma Dive

What doctors wish patients knew about breast-cancer prevention – American Medical Association

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Its natural for women to worry about breast cancer, especially since many people know someone who was touched by the disease. While there is no foolproof way to prevent breast cancer, there are things you can do to lower your risk. Some factors you cant change, but knowing what can help is key to lowering your risk of breast cancer.

Breast cancer is the second most common cancer among women in the U.S.some types of skin cancer are the most common. Between 1989 and 2020, breast cancer death rates decreased by 43%, but racial and ethnic inequities still exist. While breast cancer incidence is lower among Black women than white women, the death rate is 40% higher among Black women than white women, according to the American Cancer Society. That is because about one in five Black women with breast cancer have triple-negative breast cancermore than any other racial or ethnic group. Meanwhile, Asian American and Pacific Islanders have the lowest death rate from breast cancer while Native Americans and Alaska Natives have the lowest rates of developing breast cancer. And while rare, men can get breast cancer too.

The AMAsWhat Doctors Wish Patients Knew series provides physicians with a platform to share what they want patients to understand about todays health care headlines.

In this installment, Jill Jin, MD, an internist at Northwestern Medicine and clinical assistant professor of medicine at Northwestern University Feinberg School of Medicine, took time to discuss what patients need to know about what to do to reduce their risk of breast cancer. She is also a senior physician adviser for the AMA and an associate editor forJAMA.

Know the risk factors

While risk factors for breast cancer are broad, we think primarily about agearound the age of menopause and after menopause is when breast cancer risk goes up in women, said Dr. Jin. Family history, of course, is another big one. That includes genetic mutations that we know of such as BRCA1 and BRCA2.

Theres also this whole concept of estrogen exposure, which can be both endogenouswithin the body or how much your body producesversus exogenous, from medications she said. Then other things like alcohol and smoking are thought to be associated somewhat with breast cancer as well.

Start screening between 40 and 50

Overall, the recommended age to start screening for breast cancer in average-risk women would be anywhere from 40 to 50 years old, said Dr. Jin. It is important to convey to patients that most professional societies do recommend later than 40, either 45 or 50, as the age to start screening. But most physicians are still starting on the earlier end of this spectrum because it can be a tough sell for patients to say, wait until 50 years old when, to be honest, most people around them are probably getting screened earlier.

Almost everyone knows somebody these days who has had breast cancer, whether its a friend or a family member, and when you have that personal connection its scary, she added. Thats why I usually tell women who are at average riskwho dont have family history of breast cancerthat I am comfortable waiting until 45 years old to start screening.

If they do have a family history of breast cancer or other risk factors, we certainly can and should start screening earlier, Dr. Jin said. Its very individualized at the end of the day.

Different screening tests are available

There are several different screening modalities, said Dr. Jin, noting that a mammogram is the most common one. Other methods of screening include ultrasounds, as well as a breast magnetic resonance imaging.

But for most people, we start with mammograms, she said.

Earlier screening isnt always better

It always begins with getting to know the patient, asking about their history and their lifestyleits definitely an individualized risk assessment first, said Dr. Jin. And if there is nothing that suggests they are at higher risk than average, then you can have a discussion with patients about potentially waiting to start screening.

It comes down to the benefits versus the harms of screening, she added, noting the younger you start screening, the more lives you will save because you will catch more cancers at earlier stages, especially the more aggressive ones.

But on the flip side, the younger people are, the more you pick up things that are not cancer, which is called a false positive finding. Younger women have denser breast tissue, and when breast tissue is dense, it is very hard to differentiate normal tissue from something that may look like cancer, Dr. Jin explained. And then you go down this whole path of follow-up testing which includes additional mammograms and sometimes biopsy, which very often ends up being an unnecessary biopsy because everything will turn out normal.

This causes a lot of anxiety. It upends patients lives for a couple months while this whole process is going on, and that amount of anxiety affects many other parts of patients livesit is not trivial, she added. And then you do it all over again the next year. The younger you start, the more the potential harms of these false positives start to outweigh the potential benefit of earlier diagnosis.

Maintain a healthy lifestyle

For all womenreally for everyoneit is important to maintain a healthy lifestyle, said Dr. Jin. That means eating a balanced diet, not drinking too much alcohol, not smoking, maintaining regular physical activity and a normal body mass index.

All of those things are likely helpful for prevention of not just breast cancer, but other cancers as well, along with cardiovascular diseasea lot of things, she added.

There are medications to reduce risk

Chemoprevention, or the use of medications, is another option to reduce breast-cancer risk, said Dr. Jin. For chemoprevention, there are two classes of medications that are used. One is called selective estrogen receptor modulators, or SERMs.

Tamoxifen is probably the most common one that is used. SERMs medications block the effects of estrogen in the breast, she added. Another class is called aromatase inhibitors. Those are usually used in older women after menopause and stop other hormones in the body from becoming estrogen.

However, both have other side effects. While tamoxifen blocks the effects of estrogen in breast tissue, it can actually enhance estrogen effects in other parts of the body, so we do worry about blood clots as well as uterine cancer, said Dr. Jin. And then aromatase inhibitors can cause other side effects related to low estrogen such as hot flashes, bone pain, decreased bone density, and increased risk of osteoporosis and fractures.

Thats why we dont use these medications in everyone to decrease breast cancer risk, and reserve them for high-risk women only. Again, as with every decision in medicine, we want to make sure the balance of potential benefits versus harms is in favor of benefits, she said.

Surgical prevention is also an option

The other kind of prevention would be surgical prevention, said Dr. Jin. This is also done for women who are high risk, most commonly because of the BRCA gene mutation.

People who have a known BRCA gene mutation, which puts them at an increased risk for both breast and ovarian cancer, are candidates for surgery to remove the breasts. Thats called prophylactic mastectomy, she said. They also may be candidates for surgery to remove the ovaries to decrease the risk of ovarian cancer as well.

Test for the BRCA gene mutation

There are calculators that can be used to calculate whether someone, based on their family history and ethnicity, should get genetic testing for the BRCA gene mutation, which is a blood test said Dr. Jin. If you have a first-degree family membersuch as your mom or siblingwho has breast cancer and is known to have BRCA, then you should get tested for it.

If you just have a family history of breast cancer with unknown BRCA status, thats when the calculators come into play, she added, noting they look at how many first-degree and second-degree relatives, whether you are of Ashkenazi Jewish descent, and certain other risk factors to decide whether you should get the genetic testing.

Breastfeeding may reduce risk

While there are no clinical trials on this topic, there is observational data that does suggest that breastfeeding is protective against breast cancer, said Dr. Jin. The same goes for having children versus not having children; pregnancy does seem to be protective as well.

Were not saying go get pregnant and breastfeed to reduce your risk of having breast cancerits not practical, she added. But it does seem to be an association.

Birth control is OK to take

This is also somewhat controversial, but overall, the link between birth control and breast cancer is very small to none, Dr. Jin said. When I talk with my patients about this, I share that using birth control pills most likely does not increase the risk of breast cancer in a clinically significant way.

Furthermore, this very small potential increase in risk is limited to the time that youre actually taking birth-control pills, she said. So, its not a permanent effect. Its temporary.

Be cautious with self-breast exams

There has not been any good evidence to show that self-screening has any overall benefit in mortality, said Dr. Jin. Breasts are just lumpy to begin with and a lot of people end up feeling lumps that just end up being normal breast tissue.

And you may end up, again, going down that path of all the imaging and the biopsies and in the end, it is nothing, she added. So, self exams are not recommended by clinical guidelines.

However, some people are going to be wanting to do that anyways and that is fine. If someone really wants to stay on top of their body, I will explain that breasts can feel lumpy or bumpy, and what they are looking for is a change from baseline. At the end of the day, you still know your own breasts and your own body the best, said Dr. Jin. So, if you feel something that is different, that you have not felt before, then you should let me know and we can decide at that point what to do,

If they are in the office with me, I am happy to do a quick exam of the breast and tell them this is what your normal breast tissue feels like, dont be alarmed if you feel this or if you feel this. It is just normal.

Dont hesitate to talk to your doctor

While screening is recommended to start between 40 and 50 years old, if at any point you do notice something like a lump or you see something weird on the skin or if you have pain or any symptoms that are different than normal, that takes you out of the typical screening category, she emphasized. As with all cancer screening, when a symptom is detected that is different, and you should never hesitate to bring that up to your doctor.

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What doctors wish patients knew about breast-cancer prevention - American Medical Association

UNC School of Medicine Awarded $3 Million to Lead Study to Reduce PTSD Frequency, Severity | Newsroom – UNC Health and UNC School of Medicine

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Led by Sam McLean, MD, MPH, University of North Carolina at Chapel Hill researchers and collaborators were awarded $3 million from the U.S. Department of Defense for to evaluate the efficacy of a therapeutic to reduce the frequency and severity of acute stress disorder and posttraumatic stress disorder.

The UNC Institute for Trauma Recovery in the UNC Department of Psychiatry has been awarded a $3-million grant from the U.S. Department of Defense (DoD) to investigate the potential of a therapeutic agent to reduce the frequency and severity of acute stress disorder and post-traumatic stress disorder (PTSD). Acute stress disorder refers to the bodys immediate response to trauma, whereas PTSD is the long-term effects of trauma.

Historically, we have been able to provide emergency care to address immediate and long-term problems after visible wounds using tools such as sutures and antibiotics. However, we still have nothing to offer trauma survivors, whether in the emergency department or on the battlefield immediately after trauma, to prevent the development of invisible wounds, said principal investigator Samuel McLean, MD, MPH, professor of psychiatry and emergency medicine and director of the Institute for Trauma Recovery at the UNC School of Medicine. We need to investigate potential treatments like ACER-801 in an effort to better address these challenges.

The proposed OASIS trial will examine the safety and efficacy of ACER-801 (osanetant) to reduce acute stress response symptoms, posttraumatic stress disorder symptoms and behavioral changes among patients presenting to the emergency department after a motor vehicle collision.

Participating sites will include Washington University in St. Louis, University of Massachusetts Chan Medical School, Rhode Island Hospital, University of Florida College of Medicine Jacksonville, and Indiana University School of Medicine. The study, proposed to begin in the first half of 2023, will evaluate the efficacy of ACER-801, which Acer Therapeutics licensed from Sanofi in 2019.

The OASIS trial builds upon a foundation of knowledge and infrastructure developed through the UNC-led, $40 million AURORA initiative. The AURORA study is a major national research initiative to improve the understanding, prevention, and recovery of individuals who have experienced a traumatic event. AURORA is supported by funding from NIH, One Mind, private foundations, and partnerships with leading tech companies such as Mindstrong Health and Verily Life Sciences, the healthcare arm of Googles parent company Alphabet.

We are proud to be partnering with a leading academic institution in the field of trauma recovery as we begin exploring ACER-801 as a treatment option to reduce the frequency and severity of acute PTSD, said Adrian Quartel, MD, FFPM, Chief Medical Officer of Acer. The data from thousands of motor vehicle collisions collected through the AURORA initiative should allow us to better predict the correlation of the emergence of acute stress disorder or PTSD symptoms following a motor vehicle collision.

Added Brandon Staglin, President of One Mind We are thrilled to see how our funding to the AURORA initiative over the last five years is accelerating further advancements such as the OASIS Trial. The targeted outcomes of the OASIS Trial are the types of results that One Mind supports and of incredible value to anyone who experiences trauma and traumatic stress.

Acute and chronic stress disorders can affect both civilian and military populations. According to the National Center for PTSD, in the US about 60% of men and 50% of women experience at least one trauma in their lives. In the United States alone, one-third of emergency department visits (40-50 million patients per year) are for evaluation after trauma exposures, and in a 2014 study involving 3,157 US veterans, 87% reported exposure to at least one potentially traumatic event during their service.3 Moreover, as many as 500,000 US troops who served in wars between 2001 and 2015 were diagnosed with PTSD.

Scientific rationale for OASIS:

TheTacr3gene encodes tachykinin receptor 3 (NK3R), which belongs to the tachykinin receptor family. This family of proteins includes typical G protein-coupled receptors and belongs to the rhodopsin subfamily. NK3R functions by binding to its high-affinity ligand, Neurokinin B (NKB), which is encoded by the Tac3 (human) gene.

The role ofNKB-NK3R in growth and reproduction has been extensively studied, butNKB-NK3R is also widely expressed in the nervous system from the spinal cord to the brain and is involved in both physiological and pathological processes in the nervous system. In animal models, Tac2 mRNA levels are rapidly up-regulated during fear consolidation 30 minutes after fear conditioning, and subsequent NKB-NK3R activation can lead to over stress sensitization and the consolidation of fear, and treatment with osanetant has been shown to block a critical fear/stress sensitization step in the brain. An effective therapeutic to reduce acute and persistent/long-term psychological and somatic symptoms would fulfill a large unmet need.

Media Contact: Mark Derewicz, 919-923-0959

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UNC School of Medicine Awarded $3 Million to Lead Study to Reduce PTSD Frequency, Severity | Newsroom - UNC Health and UNC School of Medicine

The Evolution of Godless Practices: Eugenics, Infanticide, and Transhumanism – The Epoch Times

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Commentary

There is a straight line that runs from eugenics through infanticide to transhumanism. All three are the devils work in the material world.

Let us explore the issue.

From biblical times to the present, there has been an ongoing battle between good and evil that has been waged through the centuries. On one side, there are those who believe in a higher power and that mankind was made in the image of God, which is an immutable constant not to be trifled with or corrupted by human beings. Another way of saying that is that people in this camp believe that human nature itself has been immutable and constant through the millennia and that only by looking to God can mankind improve his condition.

On the other side are those who deny the existence of God and believe that mankind is the supreme intelligence in control of human destiny, is malleable and can be shaped through science, and can evolve to a superior form of man through the planning and experimentation by natural leaders over time. A corollary for the people in this camp is that there are no moral or religious constraints on their practices intended to evolve mankind toward some conceivedand ever-changingfuture vision.

Many in the first camp would characterize the ongoing battle as good versus evil. Mankind has been arguing about, defining, and redefining what it means to be good for millennia. The ancients defined good in terms of normal versus different, knowledge versus ignorance, and later right versus wrong in the context of defining laws and justice. Societies and governments were organized around these concepts.

The concept of evil has also been defined by many cultures through the ages. The dictionary now defines evil as morally wrong or bad; immoral; wicked. Most Americans (and most people in general) have an innate understanding of what is evil on a personal level. Some refer to that understanding as a conscience. Even the people in the second camp who believe that mankind is the supreme being have vestiges of consciences informed by religion and experience.

Governments have been organized to reflect, monitor, and control the cultural norms of the people governed. Logic dictates that those governments would also implement and enforce those cultural norms from a different philosophical framework from each other, partly as shaped by their respective religious philosophies and the various ideologies that have been developed and tested over the centuries, such as monarchical rule, Marxism, fascism, socialism, communism, corporate capitalism, patriarchy, oligarchy, philosopher kings, etc.

The totalitarian ideologies that were developed and tested during the 20th century (particularly fascism and communism) denied the existence of God so that the governments formed that exercised those ideologies would be unconstrained by religious and moral boundaries in their pursuit of developing and grooming their version of modern man in their societies.

Examples of those perversions of mankind include the following:

The Nazis were obsessed with racial theories that resulted in a pseudoscientific racial classification system in which Aryans (people of German and Nordic descent) were considered to be the master race at the apex of the human pyramid and destined to rule the world (on Nazi terms, of course). Jews were by Nazis to be on the lowest level of the hierarchy.

Nazi society was organized around these concepts to develop and promote those with the purest Aryan blood at the expense of those with lesser classifications in the hierarchy. For example, German boys were educated, inculcated, and groomed in Nazi principles through the Hitler Youth program. Girls were brainwashed through two parallel programs: Young Girls was an organization for girls aged 10 to 14, while the League of German Girls was for girls aged 14 to 18, with the latter being focused on comradeship, domestic duties, and motherhood.

Soviet Man was to be the ultimate proof that communism worked and that mankind could evolve for the better (as defined by the communists) without Gods guidance. The Russian communists attempted to shape the individual consciousness, character, and social practices in order to get the people to conform to the Marxist view of the perfect citizen.

The Soviets experimented with telepathic research, cybernetic simulations, and mass hypnotism over television to control the minds of their citizenry. This was a forerunner of the mass formation psychosis being exploited by the left and globalists these days.

The Chinese Communist Party (CCP) has controlled education in China for decades to politically indoctrinate students at all levels according to CCP ideology, principles, history, racial theories, global objectives, etc., and, most importantly, conditioning everyone to acquiesce to the CCPs control of all aspects of Chinese society.

CCP leader Xi Jinping said in 2019, We need to strengthen political guidance for young people, guide them to voluntarily insist on the Partys leadership, to listen to the Party and follow the Party.

And the CCP is leading the world in implementing social controls to monitor compliance with CCP directives by all Chinese citizens. Educate, monitor, control, and discipline: the perfect world with perfectly compliant citizens envisioned for all by the Chinese communists.

Theories initiated in the 19th century bore spoiled fruit in the 20th and 21st centuries. Karl Marxs theories (Marxism) begat the Communist Manifesto, whose godless adherents continue to plague the world today. Charles Darwins theory of evolution begat eugenics, which the National Institute of Healths Genome Research Institute defines as an immoral and pseudoscientific theory that claims it is possible to perfect people and groups through genetics and the scientific laws of inheritance. John Deweys theory of progressive education similarly haunts U.S. public education to this very day.

Eugenics was/is particularly evil. Its adherents included the Nazis and Americans associated with the Population Society, the Committee on Eugenics, which studied selective and restrictive human breeding, and the American Eugenics Society.

Former President Franklin D. Roosevelt even promoted Nazi sympathizer and eugenicist Franklin Osborn to positions in government, including chairman of the Civilian Advisory Committee on Selective Service, chairman of the Army Committee on Welfare and Recreation, and chief of the Morale Branch of the War Department.

The Nazis used eugenics to justify the sterilization and ultimately the elimination of undesirables, including Jews, homosexuals, gypsies, Slavs, and others. Eugenics theories led directly to the Nazi genocide that killed millions in Europe in the 1930s and 1940s.

Eugenics was also the basis for implementing sterilization laws in the United States in over 30 states, with some of those laws persisting on the books until the 1980s, according to the NIH Genome Research Institute. Over 60,000 people deemed to be idiots, imbeciles, promiscuous (females), or feebleminded were sterilized in the United States in the 20th century.

Eugenics also heavily influenced Margaret Sanger. A eugenicist and racist, Sanger founded the Birth Control League (1921) and its successor, Planned Parenthood (1942). She supported several eugenics initiatives: sterilization of people with mental and physical disabilities, segregation in concentration camps of undesirable criminals (for example, prostitutes, paupers, drug addicts, and the unemployed), and mandatory birth control training for mothers with serious disease (choice was not part of the equation).

Another of Sangers initiatives was the Negro Project, in which predominantly black neighborhoods were targeted for birth control programs. Its purpose was evident, as she later disclosed in a private letter in December 1939: We dont want word to go out that we want to exterminate the Negro population.

Planned Parenthood was, of course, one of the main organizations behind the passage of Roe v. Wade in 1973. The U.S. Supreme Court decision claimed that a womans right to an abortion was implicit in the right to privacy protected by the 14th Amendment of the U.S. Constitution. As a selling point, its advocates first claimed that abortions should only be performed in rare instances, such as rape, incest, or to save the mothers life.

Once the federal government funded Planned Parenthoods abortion clinics, abortion advocates incentivized by federal money pushed the boundaries of acceptable abortions from within the first trimester to eventually the evil practice of partial-birth abortions, in which a child being birthed is halted halfway and killed with scissors to the neck. Thus, simple therapeutic abortions have evolved to infanticidethe barbaric killing of children.

It should be noted that Adolf Hitlers Nazis were rightfully accused of committing genocide by killing 6 million Jews during the Holocaust. Similarly, communist China has been accused of committing genocide against 2 million Uyghurs in Xinjiang. However, these numbers pale in comparison to 63 million, which is the number of children aborted in the United States since the passage of Roe v. Wade in 1973. That number includes over 19 million black babies aborted. That is real genocide, whose underpinning philosophy is evil, as eugenics has become infanticide.

The newest effort by the godless camp to meddle with the natural course of humanity is the transhumanism movement, which seeks to accelerate human evolution through advanced technologies. It is a segue from eugenics because it aims to enhance the human species through the addition of advanced biological and physical (mechanical, bio-mechanical) technologies or, as Britannica puts it, to augment or increase human sensory reception, emotive ability, or cognitive capacity as well as radically improve human health and extend human life spans.

In short, the goal is to create super-humans who will live forever. And just like eugenics, there is no natural selection involved, but rather a selective implementation by and for those willing to pay the cost (and to be experimented upon). And there is no limit to the experimentation and no ethical constraints on applying the technologies.

God versus man. Good versus evil. The eternal struggle.

First came eugenics, then came abortion on demand and infanticide, and now there is the new horizon posed by transhumanism. That is the evolution of an evil kind! None of these have moral, ethical, or religious constraintsall are arbitrary as determined by those holding political power.

The Biden administration has cleared the decks for transhumanism through the signing on Sept. 12 of the Executive Order on Advancing Biotechnology and Biomanufacturing Innovation for a Sustainable, Safe, and Secure American Bioeconomy. Into the Brave New World we gowith much trepidation!

Views expressed in this article are the opinions of the author and do not necessarily reflect the views of The Epoch Times.

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Stu Cvrk retired as a captain after serving 30 years in the U.S. Navy in a variety of active and reserve capacities, with considerable operational experience in the Middle East and the Western Pacific. Through education and experience as an oceanographer and systems analyst, Cvrk is a graduate of the U.S. Naval Academy, where he received a classical liberal education that serves as the key foundation for his political commentary.

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The Evolution of Godless Practices: Eugenics, Infanticide, and Transhumanism - The Epoch Times

Evolution of the joint IAEA, IARC, and WHO cancer control assessments (imPACT Reviews) IARC – IARC

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5 October 2022

A new Policy Review by researchers from the International Agency for Research on Cancer (IARC), the International Atomic Energy Agency (IAEA), the World Health Organization (WHO), and partner institutions presents the evolution of the IAEA, IARC, and WHO joint advisory service to help countries assess national capacities and the readiness of the health system to plan and implement cancer control strategies. These assessments are known as integrated mission of Programme of Action for Cancer Therapy (imPACT) Reviews. The Policy Review was published in The Lancet Oncology.

The researchers describe the methodology of imPACT Reviews and present several country case studies. imPACT Reviews consist of a standardized assessment of the different aspects of cancer control prevention, early detection, diagnosis and treatment, palliation of symptoms, and survivorship as well as cancer surveillance and governance. Each agency is responsible for specific topics; the IARC assessment covers cancer surveillance and early detection.

The joint imPACT Reviews programme supports national health authorities in planning an integrated and specific approach to cancer control and measuring progress in implementation. Since the programme began in 2005, 111 imPACT Reviews have been implemented in 96 countries and more than 800 experts have been deployed.

Veljkovikj I, Ilbawi AM, Roitberg F, Luciani S, Barango P, Corbex M, et al.Evolution of the joint International Atomic Energy Agency (IAEA), International Agency for Research on Cancer (IARC), and WHO cancer control assessments (imPACT Reviews)Lancet Oncol, Published online 26 September 2022;https://doi.org/10.1016/S1470-2045(22)00387-4

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Evolution of the joint IAEA, IARC, and WHO cancer control assessments (imPACT Reviews) IARC - IARC

Bitcoin’s role in the evolution of money with University of Exeter’s Dr. Jack Rogers – CoinGeek

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Is Bitcoin just another kind of money? An undergraduate module dedicated to Bitcoin at the University of Exeter sheds light on the question by delving into the history of money. The module, called Bitcoin, Money and Trust, was launched in 2018 after a high demand from students to learn about Bitcoin.

Dr. Jack Rogers, a senior lecturer in economics at the University of Exeter launched the Bitcoin module as a precursor to an MSc Fintech course which he leads. He says participation increased tenfold in recent yearsfrom less than 50 students when it launched to 700 this year.

Despite the impressive turnout, Jack believes that probably the big number is partly driven for the wrong reasonsall the various hype and sense that you could get rich from this.

On this weeks episode of CoinGeek Conversations, Charles Miller talks to Jack about the University of Exeters Bitcoin teaching, the evolution of money and the role Bitcoin plays.

Jack points to the emergence of central banking as a step change in history. He quoted Felix Martin, the author of Money: The Unauthorized Biography, whom he recalls speaking of a compromise power structure between the central bank and the government. For the first time in centuries, a decoupling between money and the state is happening before our eyes, Charles suggests. Jack agrees, saying a new technology that allows people to potentially pay each other without using existing fiat-based systems has indeed raised fundamental questions. He pertains to the authors view on cryptocurrency and how its lead to a disruption in the payment system which central banks have been in control of for a long time.

Jack believes the disruption in central banking was inevitable eventually: I think this stuff, central bank, digital currencies and things that you see now, maybe it was coming anyway I think the emergence of Bitcoin and all the hype and everything has kind of brought that forward.

Based on Jacks comments, its safe to say that the future of money will depend on the outcome of the competition between blockchain-based payment systems. For now, he admits no one is certain as to where Bitcoin is heading.

One of my students did a great dissertation on this, speculating that in 20 years time, will there be loads of different types of money? What does it look like? I mean, no-one can really say, Jack said.

Dr. Jack Rogers is co-authoring a textbook alongside Brendan Lee and Neil Smith. The book will be out by the end of 2023.

Hear the whole of Dr. Jack Rogers interview in this weeks CoinGeek Conversations podcast or catch up with other recent episodes:

You can also watch the podcast video on YouTube.

Please subscribe to CoinGeek Conversations this is part of the podcasts ninth season. If youre new to it, there are plenty of previous episodes to catch up with.

Heres how to find them:

Search for CoinGeek Conversations wherever you get your podcasts

Subscribe oniTunes

Listen onSpotify

Visit theCoinGeek Conversations website

Watch on theCoinGeek Conversations YouTube playlist

New to Bitcoin? Check out CoinGeeksBitcoin for Beginnerssection, the ultimate resource guide to learn more about Bitcoinas originally envisioned by Satoshi Nakamotoand blockchain.

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Bitcoin's role in the evolution of money with University of Exeter's Dr. Jack Rogers - CoinGeek

Ariana Grande’s Beauty Evolution Is Something You Have To See – The List

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Centered on a fictional high school for creative teenagers, "Victorious" is arguably one of the most entertaining, funny, and stylish shows for kids and teens from the early 2010s. Ariana Grande rose to fame for portraying Cat Valentine on the show at only 16 years old (via Alexa Answers). Grande eventually starred in the spinoff, "Sam & Cat," where her loveable character moved up from a supporting role to one of the main characters. On these shows, the ditsy yet sweet Cat rocked bold red hair (via YouTube), and Grande became known for that daring hairstyle.

During this era of Grande's career, she often flaunted glossy lips, rosy cheeks, and makeup that made her eyes look bigger and wider, per YouTube, matching her character's fun-loving yet somewhat clueless personality. However, this look didn't last forever for the pop star, and Grande shared in an interview that she's more than just that playful redhead. Grande said, "The red was Cat, and that was very much a character, and it was very much a portion of my life that I love and I am so grateful for... and I think fondly of that, but again, is not me" (via YouTube).

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Ariana Grande's Beauty Evolution Is Something You Have To See - The List

Lady Gaga’s Beauty Evolution Is Something You Have To See – The List

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The late 2010s brought about another memorable change in style for Lady Gaga, which began when she was cast as wannabe singer Ally in the hit 2018 reboot of "A Star is Born."Her red carpet looks for this era were suitably sleek and feminine, with a notable example being her 2019 Golden Globes ensemble. Matching her hair to her ballgown, Gaga looked classically beautiful, especially with the subtle shimmer on her eyelids and her nude lip (via Allure).

In 2022, Gaga gradually started to bring back some of the theatricality from her early "Mother Monster" days. Photographed on the Chromatica Ball tour, her heavy eyeliner and bold lips were signature Gaga and hearken back to her wilder looks from 2009/2010. The rest of her tour outfits were equally as bold, combining black, latex, and lots of leather (via Variety).

From heavy bangs and embellished eyes to pared-back glossy lips and ballgowns, Gaga is a true performer through and through no matter the occasion.

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Lady Gaga's Beauty Evolution Is Something You Have To See - The List

Ed Jones on Pace’s evolution and being part of the family business – Mediaweek

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Pace began as the in-house advertising department of Heaths Motors, a Ford dealership, and was established in 1964.

Since those foundational years, the Geelong-based agency has grown, developed, and evolved into the modern and diverse company it is today. It is one of the longest-serving agencies in the country that is also family owned and operated.

Account directorEd Jonesspoke toMediaweekabout Paces long-standing partnerships with clients, being part of the family business and the agencys future in sustainability.

While his family ran the agency, Jones shared that his journey to his role wasnt direct. He shared that he initially studied medicine before pursuing aviation and then doing private consultations and marketing strategies in the field.

Then I ended up finding myself enjoying everything here at the agency. Its a very diverse place, and my grandfather started it up.

It was never my plan to go into marketing, advertising, events, or anything like that. But funnily enough, I just stumbled across happiness, which was very unpredicted, he said.

Unlike most, Jones dipped his toe into the media industry growing up.I used to get dragged in here during school holidays because of the family tie-ins. I was brought into the art department or whatever I could be useful in between school holidays, so call it child labour, he joked.Jones shared that he officially began working with Pace 13 years ago temporarily while studying medicine. He said: Before long, I had found myself intertwined with a number of our key accounts, and it was just fun. So, I stuck around.

Pace is led by Jones uncleNicholas Heathwho has been at the agencys helm for over two decades. He noted that during the 1990s, Heath focused on sustainability and long-term planning for the agency.

He (Heath) was trying to get the agency to a point where you didnt have to think where next weeks wages were coming. With retail, automotive and other clients at that time, work was seasonal, Jones explained.

You had four extremely painful peak workloads a year and often some lulls in between, So cash flow was not part of the operation, he added.

Jones said that his uncle examined retainer base models and long-term contracts. He also noted that Heath landed key accounts in sectors such as healthcare, government, and tourism, which gave the agency plenty of continued momentum.

Jones continued: The agency will be 60 years old in 2024 and has just been going through the most excruciatingly painful but most rapid period of growth in the agencys history. Its pretty gun-ho at the moment.

Jones shared that he is often his uncles right-hand man to their team of 24, along with two recent full-time additions and eight regular subcontractors.

Pace has four facets as an agency marketing, advertising and media, events and digital that work collaboratively.

Its probably the most diverse and comprehensive range of services all under one roof. Its done and dusted in there, Jones said.

Jones noted many of their clients go to them with complex problems that require a consolidated team to fix the issue and deliver while working as an integrated team with their organisation.

That broad skill set is super useful for our strengths. It is pretty rare, he said.

Jones noted that over the years, they adopted strategic recruitment to hire people and build a solid team of hardworking and passionate people who bring intelligence, integrity and capability to the team.

Were able to solve very complex things and quite nimbly have small or large organisations. Were finding that many small and large organisations with complex problems need people like us. Its busy, which is a good thing.

Jones shared the agency still has some of its foundation clients to this day, in addition to maintaining long-standing client partnerships, noting their average client tenure is over ten years.

Of course, we have projects and things that come and go at a much shorter timeline than that, but our client relationships last long, he said.

Jones noted the agencys previous work with the likes of Shell, Alcoa, Viva Energy, and Haymes paint, as well as healthcare clients and ASX-listed companies.

Some clients may have reshaped or changed along the way because were talking decades. But we have many clients that have been around a long time, to the point where they have more changeover than we do, and we end up being the basket of knowledge, he said.

Jones continued: There have been some accounts where we have held the baton as theyve gone through change and disruption. So, weve been the one consistent part along the way, which is rare.

When youve got clients you work with that long, you get to know them very personally and professionally. It makes for a good, strong working relationship. You do better work because you care, he added.

Jones remained tight-lipped on Paces recent wins but noted that over the decades, the agency has worked with more than a thousand projects, many of which are a part of the agencys history.

Jones shared that they often re-winning old clients and projects theyve previously worked with. He explained that sometimes such relationships are forced to change.

Jones said: You find that you recross paths, and so thats that to us is a win when you end up working with some of the more sexy, reputable brands. They give us a bit of bragging rights.

Jones added that this is often an opportunity for Pace to reprove ourselves or reimagine things for the brand. He noted: Because its not a brand-new client from scratch, often its rediscovering an existing relationship thats got some sort of history to the place.

Pace did well during the pandemic, according to Jones. But he noted that it was overwhelmingly well, that it almost got hard to keep up.

Were about getting the job done, right to a high standard, collecting the odd award along the way, but its not why we do it.

You adapt. You are whatever is required on the day. When clients have a downturn, or theres some economic decline, he said, referring to COVID and the 2008 GFC.

At the end of the day, we are a value-for-money based agency, and were always a fair price tag and hand on heart, were going to do what we said were going to do.

Jones added: So being reliable and predictable to a degree, but also providing high-quality output and the agencys diversity. We can go wherever the flavour is and adapt as we need as opposed to just being a digital or niche agency.

In an economic downturn, we thrive because we know how to cut money and create opportunity, Jones added.

Sustainability is an area the agency has its eyes set on expanding in as it looks ahead. Jones said: Its not just flavour of the month, but the whole sustainability sector, particularly as everyone hits for net zero. Theres a lot of stuff were doing in that kind of space.

We also do a lot of economic development work and in tourism. Weve taken upon ourselves to provide a bit of leadership in that space, Jones added, highlighting a recent state government event led by Pace on zero-emission vehicles.

Jones noted that the event showcased plenty of technological innovation their existing clients are interested in as they adapt and reshape their footprints.

Jones also noted that the agency has been keeping busy with the demand for content as businesses catch up post-pandemic. He said: We cannot produce enough. At the moment, we think were on top of it and getting asked to do more.

The flavour is shifting from clicks and basic metrics against engagement to the quality of attention were generating and what that means, he said.

Pace re-joined as a member of the IMAA earlier this year at the suggestion of the agencys head of growth,Simon Larcey.

As a member, Jones noted that the agency has enjoyed a range of benefits with the industry body, including industry awareness, staff training and industry representation.

Jones added: Having a network and shoulders to tap on for various resources or requirements or knowledge is always good.

Top image: Ed Jones

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Ed Jones on Pace's evolution and being part of the family business - Mediaweek

Preply’s insight in technological evolution of language learning FE News – FE News

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Preplys Daniele Saccardi offers insight into the technological evolution of language learning

Once upon a time, screens acted as cold separations from the warmth of other people.However, they have now become an integral part of our daily lives that offer us the chance toconnect with people that we otherwise would not have. The arrival of Covid-19 also saw anincrease in the usage of video platforms as educational tools. Children attended school fromtheir living rooms and students completed degrees from their beds.

Language learning especially has benefited from the transition to digital platforms in a waythat other subjects have not. Online video software has provided a platform for people in theUK to access native speakers as far away as Japan. Distance is no longer an object inaccessing native speakers of a learners target language.

Ukrainian startup Preply has wagered a considerable amount of time on the development oftheir own digital platform to teach languages and its paying off, with the companyexperiencing considerable growth.

We spoke with Preplys Campaign Manager, Daniele Saccardi, about how the languagelearning sector has evolved in the past decade and how the pandemic has influenced thetransition to digital learning:

Learning a language used to be all about memorising vocabulary and understandinggrammatical theory. However the world has adapted to a new communicative approach,emphasising the importance of being able to express oneself and share information in thetarget language. Not only is this approach more practical, as it allows the learner to beginspoken practice immediately, it is also beneficial for improving confidence, motivation andmemorisation.

Language learning technology has evolved to adapt to this communicative approach and fitinto an ever shrinking world. Far from the days of Software DVDs that we used in the earlypart of the century, we now have access to a variety of digital tools, such as mobileapplications and video conferencing platforms. The requirement to remain at home duringthe Covid-19 pandemic led to an increase in the usage of these conferencing platforms andopened up opportunities for students despite their geographical locations. Although I believethat we would have begun to rely more on technology in education, the pandemic definitelyacted as a catalyst to trigger this transition sooner.

Apps, such as Memrise and Anki, focus on providing students with key vocabulary by turningmemorisation into a game. These applications make great support tools to complementmore formal learning but can also be used as stand alone platforms to learn the basics.Some of the downfalls of these applications are dehumanisation and a lack of deeperunderstanding due to their surface level approach. Technology can only take us so far beforeassistance from native speakers is needed. Without communicating with native speakers,learners also miss out on learning colloquialisms and culture. What Preply does is bringtogether technological advances with humans, in order to bridge the disconnect between thetwo and to provide a more comprehensive and personal learning experience. Our tutors arewell versed in the merging of these two faces of language learning, allowing them to focuson building a connection with their students and tailoring the teaching to their particularneeds.

The future of language learning technology looks bright and it is worth watching this space

for advances in AI technologies. At the moment, AI is limited to spaced repetition, meaningthat the same word is repeated at regular intervals to improve memorisation. However, thereare endless possibilities to how AI can be integrated into language learning technologies inorder to improve the user experience. One such suggestion that I am aware of is the use ofchatbots that respond to your messages with personalised responses and can even providefeedback on your performance. Although this is convenient and can provide learners withmore confidence to make mistakes without being judged, I still strongly believe thatconversations with native speakers cannot be replaced due to the cultural underpinning oflanguage learning.

At Preply, we understand that each student has different requirements and so we usetechnology to complement and assist our teaching to varying extents depending on thestudent. The increased use of video conferencing platforms has opened up the world toopportunities beyond the classroom and we are proud to be a part of the ever evolvingtransition to hybrid learning.

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Preply's insight in technological evolution of language learning FE News - FE News

Empire of steel: Where Japan’s railways stand after 150 years of evolution – The Japan Times

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In one of the more lavish ceremonies of 19th-century Japan, a teenage Emperor Meiji arrived at Shimbashi in the new imperial capital of Tokyo and embarked on something entirely unprecedented for the nation: a passenger train.

On Oct. 14, 1872, the emperor opened a railway line between Shimbashi and Yokohama, a transformative miracle in an era when transport was mostly horse-drawn carriages, horseback and rickshaws.

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Empire of steel: Where Japan's railways stand after 150 years of evolution - The Japan Times

Scottie Barnes evolution may be gradual, but it is essential for Raptors – The Athletic

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EDMONTON With a crowd of almost 7,000 fans in attendance, Scottie Barnes saunters onto the court at Save-On-Foods Memorial Centre, home to a Raptors intrasquad scrimmage. While most of his teammates sprinted in when they were introduced, trying to keep the energy up, Barnes wont be rushed. He lifts his right arm and points to one end of the arena, lifts his left and points to the other. Hes a showman. He loves this stuff. After the scrimmage, flanked by Shelby Weaver, Raptors director of basketball operations and culture, Barnes is the last player out with the fans, signing autographs while practically encircled.

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A day earlier, its just him, O.G. Anunoby and assistant coach Earl Watson on the far end of the gym at the University of Victoria. Even while dealing with an injured finger for most of the season, Anunoby hit 69 above-the-break 3-pointers in 48 games last season. In his rookie of the year campaign, Barnes hit 36 in 74 games. Aside from one hot stretch in the first half of the season, Barnes wasnt much of a factor from deep, and defences routinely sagged off him. Yet, as the two sturdy swingmen launch 3s from the elbow, its hard to tell which guy is the established 3-and-D practitioner and which one is the prodigious talent who critics worried would never develop his jumper.

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Scottie Barnes evolution may be gradual, but it is essential for Raptors - The Athletic

Transport Evolution Africa Forum & Expo Drives The Renewable Energy Agenda With Record Turnout Of Africa’s Transport Sector – Africa.com

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Bridging the gap between transport and energy sectors by reducing the reliance on fossil fuels and investing in cleaner modes of transport is critical for the creation of safer and more sustainable cities in Africa. This is according to private and public stakeholders from the continent and beyond who gathered at industry eventTransport Evolution Africa Forum & Expoin Durban last week to explore opportunities to connect Africas transport system through sustainable infrastructure.

Celebrating its 10thyear, the trade show has established itself as Africas largest transport event, hosting the regions port, rail and road authorities all under one roof.

TheTransport Evolution Africa Forum & Expo2022was opened by Ms. Fikile Sithole, Deputy Director General: Transportation Services, KZN Provincial Government, and attracted big industry game changers, like Transnet, Export Credit Insurance Corporation of South Africa (ECIC), Briggeman International, Afreximbank and Dube Tradeport. The event welcomed over 2,350 people over the two-day period and included over 100 exhibitors who showcased innovative solutions across the transport industry.

Co-located with The Big 5 Construct KZN, as well as several other events including the Women in Transport Awards and The Transport CEO forum, it successfully gave visitors access to the entire African Transport Infrastructure value chain. In addition, the strategic transport forum tackled African Continental Free Trade Area implementation, infrastructure, investments and cross border policies head on, while the B2B networking platform and exhibition gave solution providers the opportunity to showcase their global innovations and products.

Highlighting the transport sectors contribution of almost one quarter to total global greenhouse gas emissions,Yaa Agyare-Dwomoh, Consultant at Frost & Sullivan Africasaid that in South Africa, over 60% of South Africas 1.2 million vehicles on the road are diesel-powered, with the remaining powered by petrol. To achieve the energy transformation required for decarbonisation, she suggested the sector would need to rely increasingly on renewable energy sources, such as biofuels, natural gas, ethanol, propane, hydrogen and electricity.

Continuing the conversation of coordinating the transformation of the energy and transport sectors was Dr Marcelo Blumenfeld, an Assistant Professor in Future Transport Systems from the University of Birmingham, United Kingdom, and an industrial fellow for Introducing Innovation at the Birmingham Centre for Railroad Research and Education (BCRRE).

While Blumenfeld admitted that many low-income countries may struggle to economically justify the implementation of electric powered railways, he said that alternative options such as battery and hydrogen were readily available, that provide viable and cost-effective ways to decarbonise railways, by upscaling existing assets without the need for fossil fuels. Using a case study carried out by BCRRE in Tanzania as an example, he illustrated how hydrogen-powered trains could reduce carbon emissions by as much as 10,000 tonnes every year.

Le-Ann Hare, Portfolio Director atleading global events company dmg events and host ofTransport Evolution African Forum & Expo,said that overall, the trade show was a categorical success. We were very pleased to have brought leading industry players from across the world to South Africa after a two-year hiatus and are confident that many valuable connections were made while bringing together like-minded people to learn and share their experiences in developing a sustainable way forward for the transport industry.

Next yearsTransport Evolution Africa Forum & Expowill be held on 20-21 September 2023 at Inkosi Albert Luthuli ICC Complex, Durban South Africa.

For more information, visit:www.transportevolution.com

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Transport Evolution Africa Forum & Expo Drives The Renewable Energy Agenda With Record Turnout Of Africa's Transport Sector - Africa.com

Jrgen Klopp praises forwards and Darwins evolution in surprise setup – The Guardian

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Jrgen Klopp praised Darwin Nez and Liverpools new-look attack as his team comfortably eclipsed Rangers to strengthen their Champions League qualification hopes at Anfield.

Liverpools victory arrived courtesy of a Trent Alexander-Arnold freekick plus a Mohamed Salah penalty but it was the understanding between a reshaped forward line that enabled Klopps team to dominate Rangers, who remain without a point and a goal on their return to the Champions League stage.

Nez, making his first European start for Liverpool and only his third in total, was denied several times by the veteran Rangers goalkeeper Allan McGregor but impressed throughout. Klopp insisted it is only a matter of time before the Uruguay international is rewarded with his first goal at Anfield.

The Liverpool manager said: The way the boys up front moved together was extremely, extremely good, especially for only one session working on it. And that was a lowintensity session because of their recent workload. We never did it before. You saw how good a striker Darwin is to be constantly in those situations. Everybody saw tonight that this will happen. All good.

I think our setup was the bigger surprise tonight. We surprised ourselves and these situations can then happen. It was difficult to defend. Diogo Jota moved particularly well between the lines. It was a difficult game and occasion for Rangers but we respect them a lot. We dont think we are halfway through. Next week will be different. It was 2-0, a top game, good result, lets go from there.

Alexander-Arnolds goal was a timely reminder of his attacking quality following recent criticism of his defending and the doubt over his England place at the World Cup.

He played a good game, especially defensively, and scored a wonderful goal, Klopp said. Trent didnt have a defensive problem, we had a defensive problem. We were not in the perfect moment so we had to adjust. It was a wonderful goal. Its a long time since he scored a free-kick so I am happy he had that still in his locker.

Kick off your evenings with the Guardian's take on the world of football

Rangers manager, Giovanni van Bronckhorst, admitted Liverpool were on a different level and his team have to improve when the teams meet again at Ibrox next week. I think we improved in the second half but the level we face is very high, he said. Dont forget the level of the opposition. Before the game everybody said Liverpool was out of form but you can see the quality. The gap is obvious.

We are competing against one of the best sides in Europe. I think we competed really well. We will learn from this game and we should take those experiences into the next game and the league.

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Jrgen Klopp praises forwards and Darwins evolution in surprise setup - The Guardian

Can Litecoins latest developments make LTC an investor favorite in Q4 – AMBCrypto News

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Litecoin [LTC] had a difficult seven days, as the cryptocurrency couldnt perform as per investor expectations. The alt registered a mere 1% seven-day gains. According to CoinMarketCap, LTC at press time, was trading at $53.39 with a market capitalization of more than $3.8 billion.

In an interesting revelation, CRYPTOWZRD, a popular crypto analyst, pointed out that Litecoin was following Bitcoins [BTC]overall sentiment and movements.

The findings of this analysis were evident by looking at both the charts of both the coins as they registered similar growth in the last few days.

For instance, at press time BTCs and LTCs one-hour growth was 0.03% and 0.16% respectively. Nonetheless, the Litecoin ecosystem witnessed a few upgrades and developments. These may have the potential to help the coin move up in the days to come.

______________________________________________________________________________________

Here is AMBCryptos Price Prediction for Litecoin (LTC) for 2023-24

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Recently, Litecoin developers pushed a new update called MimbleWimble Extension Blocks. According to them, this is the largest upgrade in the LTC blockchain as it will increase LTCs scalability over ten fold. This development looked pretty promising as it increased the blockchains capability considerably.

However, despite the effort, things in the short-term didnt seem to be in LTCs favor as several metrics suggest a possible downfall in the coming days.

For instance, though the Market Value to Realized Value (MVRV) ratio registered a slight uptick, it was still considerably down. Litecoin also didnt manage to gain much traction from the crypto community, which was evident by looking at LTCs social volume as it decreased over the last week.

Earlier this month, Santiments data also revealed that LTC gained the third spot on the list of cryptocurrencies with the most daily active addresses. However, things might have changed a bit over the last few weeks, as LTCs daily active addresses declined as compared to late September. Nonetheless, LTCs development activity had spiked lately, which was a green flag.

Furthermore, data from on-chain intelligence platform Glassnode pointed out that LTCs reserve risk decreased in the last week. This meant that traders could invest in LTC.

LTCs daily chart portrayed an ambiguous picture as a few market indicators supported a price hike, while the rest suggested otherwise. For instance, the Moving Average Convergence Divergence (MACD) displayed a bullish crossover, which might help the coin climb the ladder in the coming days.

The Bollinger Bands (BB) data revealed that LTCs price might soon enter a high volatility zone after registering a weeks-long sideways monument. This may increase the chances of a northbound breakout.

The Relative Strength Index (RSI) and Chaikin Money Flow (CMF) were both near neutral positions, suggesting that the market could head in any direction. However, the Exponential Moving Average (EMA) Ribbon indicated sellers advantage in the market as the 20-day EMA was resting below the 55-day EMA. This may minimize the chances of an uptick in the short-term.

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Can Litecoins latest developments make LTC an investor favorite in Q4 - AMBCrypto News

Why Bitcoin-, Ethereum- And Litecoin-Related Stock Coinbase Is Getting Hammered – Coinbase Global (NASDAQ – Benzinga

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Coinbase Global Inc COIN shares are trading lower by 10.34% to $66.27 going into the close of Friday's trading session. Shares of several banks and financial services companies are trading lower amid overall market weakness following better-than-expected U.S. unemployment data, which could negatively impact lending as it dims the outlook for a Fed policy pivot. A rise in Treasury yields have also weighed on the sector.

Coinbase is also trading lower in sympathy with the price of Bitcoin BTC/USD and Ethereum ETH/USD.

Bitcoin and Ethereum are trading lower by 2.72% to $19,400 and 2.24% to $1,320, respectively, going into the close of Friday's session.

See Also:Why Microsoft Shares Are Diving

What's Going On In The Broader Market?

The U.S. added 263,000 jobs last month, outpacing average economist estimates of 250,000 jobs, according to Benzinga Pro.

Newdatafrom the Bureau of Labor Statistics showed the U.S. unemployment rate at 3.5%, beating the 3.7% level economists had projected. The labor participation rate dropped 0.1% to 62.3%, compared to the 63.4% pre-pandemic rate in February 2020...Read More

According to data fromBenzinga Pro, Coinbase has a 52-week high of$368.90and a 52-week low of$40.83.

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Why Bitcoin-, Ethereum- And Litecoin-Related Stock Coinbase Is Getting Hammered - Coinbase Global (NASDAQ - Benzinga

You Will Miss Huge Gains by not Buying Oryen (ORY), Binance Coin (BNB), Litecoin (LTC) and Cardano (ADA) – CoinChapter

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Mauris porttitor viverra enim, quis scelerisque velit aliquet et. Class aptent taciti sociosqu ad litora torquent per conubia nostra, per inceptos himenaeos. In luctus dui nec metus viverra posuere. Mauris ac urna dui. Pellentesque ac feugiat metus, eu tempus neque. Ut molestie interdum odio. Donec vulputate dapibus nibh sed hendrerit. Donec mollis quis mi et volutpat. Nunc lacinia mollis varius.Vivamus vel accumsan urna, luctus bibendum urna. Sed est sem, convallis a mauris nec, suscipit posuere orci. In hac habitasse platea dictumst. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Duis in eros pharetra, sollicitudin urna luctus, sagittis sapien. Integer hendrerit elit mi, a sagittis sem facilisis fermentum. Quisque efficitur nisl leo, sed sollicitudin mauris tincidunt at. Aliquam vitae eros at quam aliquam efficitur id at est. Phasellus blandit ex sem. Donec vel sem vitae augue sollicitudin convallis cursus at nunc.Proin tincidunt sodales dictum. Maecenas in rhoncus augue. Suspendisse at pretium nulla. In efficitur ornare magna sit amet elementum. In ultricies tempor libero. Vestibulum risus arcu, sodales id ullamcorper quis, commodo eu ante. Morbi ac arcu diam. In hac habitasse platea dictumst. Etiam quis arcu massa. Quisque sit amet tortor fringilla, congue massa ut, interdum purus. Ut lacus tortor, fermentum id cursus sit amet, sagittis sed est. Pellentesque blandit gravida nunc, ac mollis nisl euismod at. Nulla et blandit sapien, vel porta dolor. Donec suscipit sed arcu id blandit. Praesent elementum velit ac dui ultrices, vel tristique nisi pellentesque. Vestibulum ut consequat leo.Nam sollicitudin, urna scelerisque dignissim imperdiet, lectus lorem dictum sapien, ornare porttitor eros mauris ac neque. Aenean dignissim metus nec lectus auctor rutrum. Nunc placerat leo et est rutrum, at lacinia lectus congue. Integer rhoncus lacinia cursus. Maecenas feugiat metus eget sem sollicitudin gravida. Vivamus nec erat massa. Maecenas mauris magna, malesuada at accumsan ac, commodo a nunc. Sed placerat ante libero, in hendrerit nibh rutrum ultricies. Nam a libero sit amet eros aliquam mattis id ac tortor. Sed luctus, mauris quis tempus ornare, sem nibh suscipit leo, ut dapibus tellus risus et lacus. Praesent nec feugiat purus. Vivamus facilisis tristique risus accumsan tincidunt.Pellentesque aliquet ex sit amet lacinia mattis. Vivamus eget feugiat erat, id egestas mi. Nullam non nunc eleifend elit malesuada gravida. Curabitur lacinia quam id tellus congue, a eleifend turpis varius. Vestibulum vitae leo id metus gravida malesuada quis sed lectus. Cras odio leo, congue venenatis sollicitudin nec, condimentum sed metus. Proin ornare velit at elit vulputate, eget condimentum eros aliquam. Quisque tempus nulla ac nulla tristique, a elementum ante placerat. Sed mattis ut nunc sed rutrum. Ut vel massa non est fringilla mollis sit amet in libero. Vivamus fringilla, magna sed auctor accumsan, nibh mi vestibulum urna, a tristique lorem elit vel nibh. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Nam lectus massa, tincidunt eget magna vel, mattis luctus odio. Sed neque lorem, lacinia ut metus quis, porta pretium lorem. Ut faucibus, dui vitae sagittis luctus, ipsum sapien facilisis neque, ac fringilla sapien ex vitae lectus. Curabitur congue risus semper, consequat lacus ut, blandit lorem.Integer ullamcorper felis et dolor rhoncus, vitae cursus elit laoreet. Etiam quis sodales ante. Vivamus tempus massa vitae ipsum ullamcorper varius. Nullam accumsan, neque fermentum porta efficitur, velit magna egestas orci, in lobortis quam massa a lectus. Sed quis suscipit sapien. In accumsan blandit tincidunt. In fermentum vestibulum dignissim. Sed sed velit eget dui tincidunt efficitur. Donec nec lacus quis erat porttitor venenatis.Sed arcu mi, mattis non sollicitudin a, blandit ut erat. Morbi non pellentesque ante. Morbi eget commodo ipsum, at vestibulum sapien. Nam fermentum sapien sed risus euismod, id sagittis quam rutrum. Cras volutpat rutrum consequat. In varius mauris quis nunc tempus finibus. Nam id maximus felis, eu laoreet ligula. Praesent accumsan felis in facilisis interdum. Class aptent taciti sociosqu ad litora torquent per conubia nostra, per inceptos himenaeos. Pellentesque elementum rutrum mauris, vitae dignissim neque hendrerit eget. Ut in turpis mauris. Morbi aliquet lorem lobortis est rutrum laoreet. Aliquam egestas at nibh nec auctor. Nunc eget maximus nisl. Vestibulum diam tellus, luctus at gravida volutpat, commodo id est.Duis sagittis elementum tellus sit amet consectetur. In dolor nisi, fermentum ac felis eu, semper gravida nunc. Duis a augue id neque suscipit egestas. Morbi lobortis commodo pretium. Phasellus accumsan dignissim volutpat. Nunc placerat lobortis elit, quis ullamcorper sem sagittis eget. Aliquam eu mollis nisi. Curabitur luctus ornare velit, eget luctus dui commodo interdum. Quisque vel metus orci. Phasellus lorem nunc, maximus id posuere ac, commodo nec nibh. Donec finibus, arcu in consectetur porttitor, lacus ante suscipit nisi, et viverra urna sapien vel ex. Etiam mattis enim sit amet turpis ultrices laoreet. Sed in finibus mauris. Duis at eleifend lacus. Aenean semper erat urna, pulvinar iaculis felis rhoncus quis.Nuc ucipit sem,Lorem ipsum dolor sit amet, consectetur adipiscing elit. Aliquam suscipit ante ante, malesuada eleifend est efficitur id. In posuere arcu vel nisi congue, eget aliquam urna lacinia. Donec eu ultricies ex. Aenean at nunc sit amet magna lacinia volutpat et scelerisque ligula. In hac habitasse platea dictumst. Quisque eleifend nibh at justo rutrum, vel vulputate diam feugiat. Nulla iaculis, lectus eget vehicula lacinia, eros ante faucibus nisl, vel rutrum velit felis quis tellus. Proin in sem in justo posuere consectetur.Quisque vestibulum quam sit amet gravida pulvinar. Sed semper lorem eu rutrum varius. Sed feugiat porta felis ut ultricies. Nulla ac mollis lectus, id venenatis dui. Pellentesque in tristique magna, eu ultricies diam. Aenean sed quam arcu. Fusce pretium tincidunt ultrices. Sed eget pulvinar ante.Aenean elementum nisl vitae sem tincidunt, in sagittis velit euismod. Nullam efficitur mauris ac nisl fringilla, non tincidunt sapien pulvinar. Mauris in leo vel nunc gravida ullamcorper. Cras dignissim lobortis est, id egestas massa elementum non. Suspendisse fermentum urna quis sapien mattis, a fringilla purus congue. Cras malesuada scelerisque eros eget facilisis. Orci varius natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Donec congue turpis ex. Mauris aliquet aliquet ipsum eu feugiat. Nullam dapibus sem nec mi viverra, sed elementum velit tempor. Pellentesque et eros vehicula, luctus ante ut, egestas diam. Interdum et malesuada fames ac ante ipsum primis in faucibus. Quisque dui velit, egestas vel auctor at, scelerisque et diam. Donec consequat justo a tincidunt molestie. Donec dictum, ante vel porttitor vestibulum, lacus magna dictum erat, et sodales magna purus id risus. Donec cursus malesuada elit, non vestibulum nisl eleifend vitae.Maecenas vitae urna urna. Etiam id pulvinar massa. Vestibulum quis risus tellus. Pellentesque congue rhoncus nisi. Suspendisse tincidunt venenatis sapien id tristique. Nunc sed cursus odio, nec egestas sapien. Mauris eleifend nisi eu felis mollis laoreet. Cras in nunc sed nulla volutpat scelerisque. Aliquam ac dolor egestas, dapibus nisi ut, viverra nunc.Proin vel vulputate urna. Sed efficitur tempor lectus, nec lobortis libero consequat quis. Donec dapibus tempor massa vel porttitor. Sed convallis eros id dolor rutrum, non tincidunt enim egestas. Sed dapibus sem eu consectetur ultricies. Donec non dapibus libero, non congue arcu. Proin malesuada ligula et faucibus semper.Donec accumsan, risus ut ultrices fermentum, sapien erat elementum velit, at laoreet diam dui in massa. Etiam tristique ornare metus et scelerisque. Maecenas cursus volutpat ante vitae tincidunt. Cras ligula nisl, hendrerit sit amet scelerisque non, maximus ac metus. Donec iaculis sagittis hendrerit. In rutrum mi sit amet lorem aliquam ultricies. Duis porttitor volutpat ante nec porttitor. Maecenas tincidunt efficitur lorem at mollis. Pellentesque vitae arcu feugiat, posuere arcu et, posuere velit. Nulla tempor feugiat dui nec consectetur. Morbi commodo accumsan leo sit amet tincidunt. Suspendisse in lacus ex. Mauris in lorem massa.Mauris ac viverra sem. Maecenas cursus eu velit et mollis. Phasellus faucibus a elit ut imperdiet. Proin at mauris nec ipsum vehicula faucibus at non magna. Curabitur et fermentum tortor, ut consequat elit. Nullam molestie a neque nec mattis. Quisque ac libero sed erat tempor laoreet. Cras in massa eu est varius scelerisque a tincidunt nulla. Cras eu fermentum massa, a dignissim felis. Donec eros arcu, tempus vel lacus at, tincidunt maximus turpis. Suspendisse euismod augue et ipsum luctus, id tempus felis consequat.Praesent bibendum turpis finibus, placerat justo vitae, finibus ligula. Aliquam dictum mattis tristique. Mauris tincidunt magna ac orci pellentesque efficitur. Mauris in leo ac odio sodales pulvinar. Mauris porttitor viverra enim, quis scelerisque velit aliquet et. Class aptent taciti sociosqu ad litora torquent per conubia nostra, per inceptos himenaeos. In luctus dui nec metus viverra posuere. Mauris ac urna dui. Pellentesque ac feugiat metus, eu tempus neque. Ut molestie interdum odio. Donec vulputate dapibus nibh sed hendrerit. Donec mollis quis mi et volutpat. Nunc lacinia mollis varius.Vivamus vel accumsan urna, luctus bibendum urna. Sed est sem, convallis a mauris nec, suscipit posuere orci. In hac habitasse platea dictumst. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Duis in eros pharetra, sollicitudin urna luctus, sagittis sapien. Integer hendrerit elit mi, a sagittis sem facilisis fermentum. Quisque efficitur nisl leo, sed sollicitudin mauris tincidunt at. Aliquam vitae eros at quam aliquam efficitur id at est. Phasellus blandit ex sem. Donec vel sem vitae augue sollicitudin convallis cursus at nunc.Proin tincidunt sodales dictum. Maecenas in rhoncus augue. Suspendisse at pretium nulla. In efficitur ornare magna sit amet elementum. In ultricies tempor libero. Vestibulum risus arcu, sodales id ullamcorper quis, commodo eu ante. Morbi ac arcu diam. In hac habitasse platea dictumst. Etiam quis arcu massa. Quisque sit amet tortor fringilla, congue massa ut, interdum purus. Ut lacus tortor, fermentum id cursus sit amet, sagittis sed est. Pellentesque blandit gravida nunc, ac mollis nisl euismod at. Nulla et blandit sapien, vel porta dolor. Donec suscipit sed arcu id blandit. Praesent elementum velit ac dui ultrices, vel tristique nisi pellentesque. Vestibulum ut consequat leo.Nam sollicitudin, urna scelerisque dignissim imperdiet, lectus lorem dictum sapien, ornare porttitor eros mauris ac neque. Aenean dignissim metus nec lectus auctor rutrum. Nunc placerat leo et est rutrum, at lacinia lectus congue. Integer rhoncus lacinia cursus. Maecenas feugiat metus eget sem sollicitudin gravida. Vivamus nec erat massa. Maecenas mauris magna, malesuada at accumsan ac, commodo a nunc. Sed placerat ante libero, in hendrerit nibh rutrum ultricies. Nam a libero sit amet eros aliquam mattis id ac tortor. Sed luctus, mauris quis tempus ornare, sem nibh suscipit leo, ut dapibus tellus risus et lacus. Praesent nec feugiat purus. Vivamus facilisis tristique risus accumsan tincidunt.Pellentesque aliquet ex sit amet lacinia mattis. Vivamus eget feugiat erat, id egestas mi. Nullam non nunc eleifend elit malesuada gravida. Curabitur lacinia quam id tellus congue, a eleifend turpis varius. Vestibulum vitae leo id metus gravida malesuada quis sed lectus. Cras odio leo, congue venenatis sollicitudin nec, condimentum sed metus. Proin ornare velit at elit vulputate, eget condimentum eros aliquam. Quisque tempus nulla ac nulla tristique, a elementum ante placerat. Sed mattis ut nunc sed rutrum. Ut vel massa non est fringilla mollis sit amet in libero. Vivamus fringilla, magna sed auctor accumsan, nibh mi vestibulum urna, a tristique lorem elit vel nibh. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Nam lectus massa, tincidunt eget magna vel, mattis luctus odio. Sed neque lorem, lacinia ut metus quis, porta pretium lorem. Ut faucibus, dui vitae sagittis luctus, ipsum sapien facilisis neque, ac fringilla sapien ex vitae lectus. Curabitur congue risus semper, consequat lacus ut, blandit lorem.Integer ullamcorper felis et dolor rhoncus, vitae cursus elit laoreet. Etiam quis sodales ante. Vivamus tempus massa vitae ipsum ullamcorper varius. Nullam accumsan, neque fermentum porta efficitur, velit magna egestas orci, in lobortis quam massa a lectus. Sed quis suscipit sapien. In accumsan blandit tincidunt. In fermentum vestibulum dignissim. Sed sed velit eget dui tincidunt efficitur. Donec nec lacus quis erat porttitor venenatis.Sed arcu mi, mattis non sollicitudin a, blandit ut erat. Morbi non pellentesque ante. Morbi eget commodo ipsum, at vestibulum sapien. Nam fermentum sapien sed risus euismod, id sagittis quam rutrum. Cras volutpat rutrum consequat. In varius mauris quis nunc tempus finibus. Nam id maximus felis, eu laoreet ligula. Praesent accumsan felis in facilisis interdum. Class aptent taciti sociosqu ad litora torquent per conubia nostra, per inceptos himenaeos. Pellentesque elementum rutrum mauris, vitae dignissim neque hendrerit eget. Ut in turpis mauris. Morbi aliquet lorem lobortis est rutrum laoreet. Aliquam egestas at nibh nec auctor. Nunc eget maximus nisl. Vestibulum diam tellus, luctus at gravida volutpat, commodo id est.Duis sagittis elementum tellus sit amet consectetur. In dolor nisi, fermentum ac felis eu, semper gravida nunc. Duis a augue id neque suscipit egestas. Morbi lobortis commodo pretium. Phasellus accumsan dignissim volutpat. Nunc placerat lobortis elit, quis ullamcorper sem sagittis eget. Aliquam eu mollis nisi. Curabitur luctus ornare velit, eget luctus dui commodo interdum. Quisque vel metus orci. Phasellus lorem nunc, maximus id posuere ac, commodo nec nibh. Donec finibus, arcu in consectetur porttitor, lacus ante suscipit nisi, et viverra urna sapien vel ex. Etiam mattis enim sit amet turpis ultrices laoreet. Sed in finibus mauris. Duis at eleifend lacus. Aenean semper erat urna, pulvinar iaculis felis rhoncus quis.Nuc ucipit sem,Lorem ipsum dolor sit amet, consectetur adipiscing elit. Aliquam suscipit ante ante, malesuada eleifend est efficitur id. In posuere arcu vel nisi congue, eget aliquam urna lacinia. Donec eu ultricies ex. Aenean at nunc sit amet magna lacinia volutpat et scelerisque ligula. In hac habitasse platea dictumst. Quisque eleifend nibh at justo rutrum, vel vulputate diam feugiat. Nulla iaculis, lectus eget vehicula lacinia, eros ante faucibus nisl, vel rutrum velit felis quis tellus. Proin in sem in justo posuere consectetur.Quisque vestibulum quam sit amet gravida pulvinar. Sed semper lorem eu rutrum varius. Sed feugiat porta felis ut ultricies. Nulla ac mollis lectus, id venenatis dui. Pellentesque in tristique magna, eu ultricies diam. Aenean sed quam arcu. Fusce pretium tincidunt ultrices. Sed eget pulvinar ante.Aenean elementum nisl vitae sem tincidunt, in sagittis velit euismod. Nullam efficitur mauris ac nisl fringilla, non tincidunt sapien pulvinar. Mauris in leo vel nunc gravida ullamcorper. Cras dignissim lobortis est, id egestas massa elementum non. Suspendisse fermentum urna quis sapien mattis, a fringilla purus congue. Cras malesuada scelerisque eros eget facilisis. Orci varius natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Donec congue turpis ex. Mauris aliquet aliquet ipsum eu feugiat. Nullam dapibus sem nec mi viverra, sed elementum velit tempor. Pellentesque et eros vehicula, luctus ante ut, egestas diam. Interdum et malesuada fames ac ante ipsum primis in faucibus. Quisque dui velit, egestas vel auctor at, scelerisque et diam. Donec consequat justo a tincidunt molestie. Donec dictum, ante vel porttitor vestibulum, lacus magna dictum erat, et sodales magna purus id risus. Donec cursus malesuada elit, non vestibulum nisl eleifend vitae.Maecenas vitae urna urna. Etiam id pulvinar massa. Vestibulum quis risus tellus. Pellentesque congue rhoncus nisi. Suspendisse tincidunt venenatis sapien id tristique. Nunc sed cursus odio, nec egestas sapien. Mauris eleifend nisi eu felis mollis laoreet. Cras in nunc sed nulla volutpat scelerisque. Aliquam ac dolor egestas, dapibus nisi ut, viverra nunc.Proin vel vulputate urna. Sed efficitur tempor lectus, nec lobortis libero consequat quis. Donec dapibus tempor massa vel porttitor. Sed convallis eros id dolor rutrum, non tincidunt enim egestas. Sed dapibus sem eu consectetur ultricies. Donec non dapibus libero, non congue arcu. Proin malesuada ligula et faucibus semper.

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You Will Miss Huge Gains by not Buying Oryen (ORY), Binance Coin (BNB), Litecoin (LTC) and Cardano (ADA) - CoinChapter

What Is Litecoin Halving – BanklessTimes

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Last updated 7th Oct 2022

Litecoin has now been one of the most popular cryptocurrencies on the market for a very long time. It has a great brand image, along with sustained popularity and a valid use case. Often dubbed as the silver to Bitcoins gold it shares many of the same characteristics as the current no.1 crypto but with some of its own unique features too.

One of the most significant features that these two crypto-assets share is they undergo a process called Halving. Halving can have a dramatic effect on price predictions, miner activity, and the inevitable hype that surrounds a cryptocurrency.

Halving is definitely a concept that everyone wanting to learn about crypto should understand, so we have created this easy-to-follow guide to explain what Litecoin is, how Halving works, and the effects this can have on markets and miners.

Founded in 2011 by former Google engineer and software developer Charlie Lee, Litecoin enjoyed success as one of the most popular Altcoins on the market. After his time at Google Charlie Lee also worked as a director of engineering at Coinbase and was one of the first employees that the company had. His experience in the crypto space then led to the creation of Litecoin with a vision that was very similar to that of Bitcoins.

In fact, Charlie Lee launched Litecoin with the aim to be different from many of the pumps and dumps found on the market. It was unique in the way that no developers received any LTC before its ICO and similarly, there was no pre-mine.

The vision of Litecoin was essentially to be a light version of Bitcoin. If people viewed Bitcoin as virtual gold then Litecoin would be a virtual silver, facilitating cheap and faster transactions than the slower jugunaught that Bitcoin is. Litecoin also differed from BTC in its mining algorithm; instead of the SHA-256 proof-of-work system that would require miners to have specialized hardware, Litecoin would be able to be mined on any regular computer.

This is certainly a valid use-case as even today we see protocols competing to lower transaction costs and increase throughput whilst still keeping the principle of decentralization intact. In tandem with this Litecoin had a capped supply that would be halved every 4 years, just as Bitcoin. This seemed a sure-fire way to protect the value of LTC over time and mirror the deflationary characteristics of Bitcoin.

To understand what halving is we must first touch on mining. Mining is the process of contributing to the decentralized network that supports a protocols ecosystem and receiving financial rewards for doing so. People often dont understand how a network can be decentralized, and offering rewards to miners for providing that physical infrastructure that a network need is exactly how it works.

Litecoin uses a proof-of-work system that essentially means miners must solve complex mathematical equations to create a block. This block is then verified if solved, meaning it has become a verified part of the blockchain it supports and now further blocks can be built on top of it. Creating blocks is costly due to the computer power required, so miners receive rewards for doing so in the form of the native currency - in this case in LTC.

Halving is the deflationary element of the Litecoin ecosystem. It is an inbuilt function within the network that means every four years the rewards miners receive for mining blocks will be cut in half. Of course, this is not ideal for miners but in terms of tokenomics, it helps to reduce the supply of new coins. This essentially increases the value of those LTC that can be mined as now there are half as many available; this can also have a direct impact on the market price of the coin as speculators can see that there is no dilution of value. Essentially, it's a control on the supply.

Halving can have a dramatic impact on price and this is certainly the area most looked at. If the supply of LTC is reduced then usually you will see a correlative effect of an increase in market value. Vise versa, an increase in supply is usually coupled with a decrease in market value. There are also clear patterns to be seen in any halving period with the market price. Usually, miners will increase their workload before the halving period thereby reducing the market value of the asset in question. Following this and the subsequent halving prices will begin to stabilize, and can even dramatically increase under some circumstances.

The first Litecoin halving occurred in August 2015. Originally rewards for miners per block were 50 LTC, this was therefore reduced to 25 LTC. The valuation of LTC slightly rose in the period before the halving, before dropping slightly and then leveling out after the halving had taken place. LTC had previously reached highs of $32 before this first halving but seemed to then level out around about $4 after it.

Within the time between the first and second halving, LTC had significantly changed. What was around a $4 coin at the time of the first halving had now reached far over $250, so the economic environment had changed significantly. August 2019 saw the second halving take place which reduced the miners reward down to 12.5 LTC. Since this event, LTC has somewhat stabilized at its $100 support level having fallen steadily for the past four months.

Litecoins next halving is supposed to take place in August 2023 and will see the rewards for miners drop again by another 50% to 6.25 LTC. The general consensus of the crypto community is that the price of an asset will rise after a halving - but this is somewhat up for debate.

While in theory, a halving should increase the value of an asset this does not seem to always be the case in practice. We have seen with Litecoin that its halving is not necessarily the biggest catalyst in its price change. In fact, after being designed as the silver to Bitcoins gold, it seems that the BTC price is the biggest catalyst for LTC price change.

The price of an asset is determined by two factors: supply and demand.

While halving does clearly have a part to play in this there are too many other contextual factors at play that also could influence this.

Halving is an integral part of the Litecoin ecosystem; it is one of its core tools to regulate the supply of the coin and ensures that it isn't unlimited as is with some fiat. As well as this critical aspect of tokenomics it also acts as a reward system for the people that help provide the infrastructure for the Litecoin network: miners. Halving directly affects miners due to the 50% reduction of their reward for creating blocks but in tandem helps balance the financial ecosystem of the network.

While halving is theoretically supposed to lead to an increase in the value of an asset we have seen this is not historically the case with Litecoin Halving. In fact, it seems that its relationship to BTC is a much more prevalent factor and should be viewed as more meaningful than the 4-yearly halving cycle of Litecoin. We can therefore conclude that the upcoming Litecoin Halving in 2023 is unlikely to dramatically influence the value of LTC.

Can I mine Dogecoin and Litecoin at the same time?

Yes. Dogecoin is mergemined with LTC which means it is possible to mine two coins simultaneously, without requiring any extra computing power. This partnership was made to avoid Doge holders manipulating its market value.

What happens when there are no rewards for miners?

This is one of the most interesting questions in the crypto community. Technically speaking, miners will no longer receive rewards for their services in the form of new supply coins, but instead with transaction fees.

Will the value of Litecoin go up after its halving?

Historically, it looks as though Litecoin Halving does not affect the value of Litecoin to a large degree. Instead, it is its close relationship to BTC that seems to be the most significant factor.

Link:

What Is Litecoin Halving - BanklessTimes

Kubix Festival announces return to Sunderland with acts including Five, N-Trance, Ultrabeat, Flip & Fill, A1 and 911 – Sunderland Echo

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The festival says it will host its biggest event yet when it returns on July 15, 2023.

Headliners are still to be announced for the event, but acts confirmed so far are 90s and 00s favourites Five, N-Trance, Ultrabeat, Flip & Fill, A1 and 911.

Organiser Alex Hutchinson said: As a local team, we are delighted to bring the biggest pop party to Sunderland year after year and 2023 is going to be the biggest year to date. Well be bringing some huge names to Sunderland for the very first time and we know youll be as excited as we are.

New for 2023 is a partnership with the University of Sunderland which will bring an added dimension to the festival.

Earlier this year, an estimated 15,000 people attended the festivals pop and dance day on Saturday, July 9, with Ultrabeat, Vengaboys, Aqua and headliners Steps bringing the summer vibes to Wearside.

The following weekend, the festival hosted a rock and indie weekend featuring UB40, Stiff Little Fingers, Ash and more.

Its set to be a summer of events in Sunderland in 2023.

The US superstar will be getting the party started when she returns to Sunderland on Saturday, June 10 and Sunday, June 11, 2023.

Limited early bird tickets for Kubix Festival are available for 30+bf now from http://www.kubixfestival.co.uk

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Kubix Festival announces return to Sunderland with acts including Five, N-Trance, Ultrabeat, Flip & Fill, A1 and 911 - Sunderland Echo

Houston Texans offense in a trance, plus other Week 4 takeaways – Toro Times

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The Houston Texans played the Los Angeles Chargersthis past Sunday. The Chargers were the heavy favorite, but the Texans almost pulled together a comeback but once again fell short.

There are a lot of noticeable improvements from Houston, but the offense took too long to get moving as there was poor offensive play calling, and yet again, too many missed tackles on defense. The rookies looked great, but there is much to improve to become competitive.

Here are three takeaways from the Week 4 loss to Los Angeles, moving Houston to 0-3-1 overall after four games in the 2022 season.

Mandatory Credit: Kevin Jairaj-USA TODAY Sports

The Houston Texans offense has been in a trance, doing the same thing every game with no adjustments. The Texans will run the ball, which went very well, but quarterback Davis Mills will either make incorrect reads or rely on veteran wide receiver Brandin Cooks. Until the fourth quarter, Mills missed reads, threw uncatchable balls and turned the ball over twice.

When the fourth quarter came, Mills finally opened his vision and made good reads, throwing it to three different receivers. Mills made a great throw to tight end Jordan Akins and followed that up with a short pass to running back Rex Burkhead.

Mills finally targeted second-year wide receiver Nico Collins for a deep 58-yard dart. Mills looked like he did at the end of last season with a few perfect passes and more trust in Collins. Mills looked great that drive, taking the right shots downfield and throwing to multiple pass catchers.

The Texans came close to substituting Kyle Allen in for Mills and having him warm up on the sideline, but then Mills looked good in the last quarter.

If Mills doesnt play as he did in the fourth quarter on Sunday this Sunday against the Jacksonville Jaguars, he may be riding the bench very soon.

Many Texans fans are already looking into the 2023 NFL Draft, hoping to select quarterback CJ Stroud from Ohio State or Alabama quarterback Bryce Young. It may be time to move on if Mills cant blow fans away and get their belief and trust in Week 5.

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Houston Texans offense in a trance, plus other Week 4 takeaways - Toro Times