‘Roaming reactions’ study to shed new light on atmospheric molecules – UNSW Newsroom

A detailed study of roaming reactions where atoms of compounds split off and orbit other atoms to form unexpected new compounds could enable scientists to make much more accurate predictions about molecules in the atmosphere, including models of climate change, urban pollution and ozone depletion.

In a paper published today in the journal Science, a team of researchers from UNSW Sydney, University of Sydney, Emory University and Cornell University showed in unprecedented detail exactly what happens during roaming reactions of chemical compounds.

Professor Scott Kable, an atmospheric scientist who is also the head of UNSWs School of Chemistry, likens the study to lifting the hood on roaming reactions and seeing for the first time how the parts fit together. He says the study will give scientists new tools to understand the machinations of reactions in the atmosphere.

Chemical reactions, where atoms are rearranged to make new substances, are occurring all the time in our atmosphere as a result of natural emission from plants and animals as well as human activity, Prof Kable says.

Many of the key reactions in the atmosphere that contribute to photochemical smog and the production of carbon dioxide are initiated by sunlight, which can split molecules apart.

For a long time, scientists thought these reactions happened in a simple way, that sunlight was absorbed and then the molecule explodes, sending atoms in different directions.

But, in the last few years it was found that, where the energy from the sun was only just enough to break a chemical bond, the fragments perform an intimate dance before exchanging atoms and creating new, unanticipated, chemical products known as roaming reactions.

Our research shows these roaming reactions exhibit unusual and unexpected features.

Prof Kable says in an experiment detailed in the paper, the researchers looked at the roaming reaction in formaldehyde (CH2O) and were surprised to see instead, two quite distinct signals, which we could interpret as two distinct roaming mechanisms.

The theoretical and computational work was performed by a team in the US led by Professors Joel Bowman (Emory) and Paul Houston (Cornell). Prof Bowman observed that "detailed modelling of these reactions not only agree with the experimental findings, they provide insight into the motion of the atoms during the reaction".

Professor Meredith Jordan from University of Sydney says the experiments and theory results suggest roaming reactions straddle the classical and quantum worlds of physics and chemistry.

"Analysing the results with the incredible detail in both experiments and simulations allowed us to understand the quantum mechanical nature of roaming reactions. We expect these characteristics to be present in all roaming reactions, she says.

The results of this study will provide theoreticians with the data needed to hone their theories, which in turn will allow scientists to accurately predict the outcomes of sunlight-initiated reactions in the atmosphere.

Prof Kable says the study could also benefit scientists working in the areas of combustion and astrophysics, who use complex models to describe how molecules interact with each other in gaseous form.

The paper, titled Rotational resonances in the H2CO roaming reaction are revealed by detailed correlations is published online by the journal Science.It can be accessed here.

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'Roaming reactions' study to shed new light on atmospheric molecules - UNSW Newsroom

High-Performance Blockchain Platform Ontology Partners NEAR Protocol to Speed Up Development of Decentralized Identity Solutions – Crowdfund Insider

Ontology (ONT), a high-performance or high-throughput blockchain platform for enterprises, has teamed up with the developers of the NEAR Protocol in order to speed up the development and deployment of secure decentralized identity solutions.

The Ontology team will offer technical support for NEARs Decentralized Identifier (DID) from a regulatory perspective. The DID solution will have various smart contract features and will go through W3C registration.

NEAR is a decentralized application (dApp) platform that is secure enough to handle high-value assets such as money or identity and performant enough to make them practical for daily use. The NEAR project aims to put the power of the Open Web into everyones hands or reach.

NEAR has received $21.6 million in funding from giant VC firm Andreessen Horowitz, Electric Capital, and other major investors. The platforms mainnet has also been launched

Erick Pinos, Ontology Americas Ecosystem Lead, stated:

Teaming up with NEAR broadens our remit considerably when it comes to delivering decentralized identity protocols. We share common objectives in terms of broadening the accessibility of enterprise-grade blockchain applications and decentralized identity solutions and look forward to working together.

Ontology aims to continue to focus on offering fast, user-friendly, intuitive solutions with a unique infrastructure that can handle or facilitate cross-chain collaboration. Ontology offers software tools that allow businesses or company owners to develop their own blockchain-enabled solutions in a secure manner.

Erik Trautman, CEO at NEAR Foundation, remarked:

We are excited to leverage the technical acumen of the Ontology team, particularly in relation to their ONT ID 2.0, a decentralized identity solution designed for streamlined cross-chain interoperability. Following our successful MainNet launch, we are keen to strengthen our partner network, and look forward to extending the power of Ontologys solutions to our growing customer base.

In June 2020, blockchain infrastructure developer Bison Trails added support for the NEAR protocol, a sharded proof of stake (PoS) blockchain and app development platform that can power open finance solutions.

As reported recently, $150 million in ONT tokens are being staked on Ontology. There are also more than 70 decentralized applications (dApps) being supported by the blockchain development platform.

Binance, the worlds largest crypto exchange, has reportedly been paying great attention to Ontologys blockchain governance and economic model. It might consider becoming a node on the chain.

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High-Performance Blockchain Platform Ontology Partners NEAR Protocol to Speed Up Development of Decentralized Identity Solutions - Crowdfund Insider

Apparel Industry Puts Blockchain to the Test to Solve Persistent Challenges – Total Retail

While retail industry innovation efforts may be paused during this unprecedented time of social distancing and economic turmoil, a study involving blockchain, radio frequency identification (RFID), and global data standards provided a glimpse into the potentially remarkable capabilities of emerging technology to help solve supply chain challenges.

Prior to the coronavirus outbreak, the Auburn University RFID Lab, GS1 US and several leading retail companies launched the Chain Integration Project (CHIP). The groundbreaking proof-of-concept demonstrated the effectiveness of using blockchain in combination with RFID to gather serialized product information. Three brands, Nike, PVH Corp., and Herman Kay, as well as two retailers, Kohls and Macys, contributed live data to the project.

Though blockchains potential is still undefined in retail, CHIP represented a small but important step in helping to solve supply chain challenges that have plagued the industry for decades. Here are three reasons why the findings from CHIP provide insight into the potential of blockchain in this sector:

CHIP participants named claims and chargebacks as one of the costliest problems for brands and retailers (it costs them roughly 1 percent of total retail sales, according to the Department of Commerce). There's simply little to no communication of serialized data between the stakeholders involved. Claims are often settled in the absence of sufficient shipment information on both brand and retailer sides.

Though blockchain technology can hold them accountable for their agreements and create more order transparency, trading partners need to focus on the basic tenets of supply chain visibility to fully maximize blockchain for this purpose. Companies pursuing blockchain should have globally unique product identification in place (not proprietary identification numbers) as well as a uniform way to capture how the product changes hands throughout the supply chain, such as RFID. Without supply chain visibility and data completeness, order accuracy cannot be improved.

The term serialized data in the apparel industry refers to product data carried by RFID tags or QR codes that help users identify and trace individual items throughout the supply chain. While the collection of serialized data has grown in recent years, the overall benefit of item-level visibility is hindered when data isn't shared between trading partners. Doing so can help complete the visibility cycle, improving forecasting and leading to a more transparent and real-time supply chain.

CHIP was an important test for blockchain, as is could not only spur more data sharing, but it could also cast a spotlight on the importance of creating a standards-based foundation to make that achievable. Specifically, CHIP proved a GS1 data-sharing standard called EPCIS (Electronic Product Code Information Services) enabled more flexible transactional data sharing, as it records the what, when, where and why associated with supply chain events.

According to the research, the automation of serialized product data exchange using blockchain can potentially eliminate manual labor associated with legacy systems, increasing the productivity and efficiency of the retail supply chain. Legacy systems also typically dont allow for item-level visibility, so trading partners end up forfeiting much of the granular product data enabled by serialization. Blockchain supports smart contracts, meaning the automated execution of terms, conditions and business rules, and incorporating serialized data into smart contracts could enable a more resilient and responsive supply chain. For retail, this could mean fewer item substitutions, more certainty around what's being shipped and when, and fewer discrepancies downstream. Improved reconciliation is a valuable benefit when consumers are demanding more supply chain transparency and want access to trustworthy information about a products journey.

However, because not all companies are going to select the same blockchain technology partner, GS1 Standards are essential to streamline the transmission and interpretation of data. Using standardized product data to uniformly capture traceability events, for example, can enable consumers to verify that shoes from their favorite designer are genuine.

Ultimately, CHIP participants examined various problems that exist in retail today and explored blockchain as a potential tool to solve them. Overall, while the findings showed blockchain was viable, the participants were only successful in sharing data when they used blockchain and RFID in combination with GS1 Standards such as EPCIS. Through further exploration, the team hopes to continue to evaluate the addition of this technology to the transformation of the larger retail ecosystem.

Susan Pichoff is senior director, community engagement, GS1 US, astandards organization supporting and educating businesses and industries in the use and adoption of GS1 Standards to improve business processes.

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Apparel Industry Puts Blockchain to the Test to Solve Persistent Challenges - Total Retail

COVID19 Outbreak Blockchain in Education market maintaining a strong outlook heres why – Levee Report

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Competition landscape

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University, Personnel Recruitments, Digital Rights Management, Others

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Credentials Verification, Expanding MOOCs, Digital Rights Protection, Open Source Universities, School Assets Tracking & Management, Others

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COVID19 Outbreak Blockchain in Education market maintaining a strong outlook heres why - Levee Report

UK migrant crisis: RAF patrols coast as Border Force intercepts dinghy with 20 migrants – Express

An RAF plane is currently monitoring the UK coastline, as part of a big push by the Government to manage migration across the channel. The Ministry of Defence have confirmed the aircraft has been flown to "support Border Force operations in the Channel" and was authorised by Defence Secretary Ben Wallace. It comes as a boat full of migrantswere met by the Border Force patrol boat Hunter at about 7.15am this morning.

Those on board the inflatable dinghy were pictured waving and smiling as the vessel made its way across the English Channel.

Pictures from this morning show a small inflatable boat jam-packed full of people wearing orange life jackets.

At least one woman was among their number.

One migrant could be seen bailing out water with a plastic container from the boat, which sat low in the water, while another was spotted smoking a cigarette.

When asked how they were, many of the migrants put their thumbs up and replied that they were OK, according to PA news agency.

The boat was met by Border Force as they neared Dover.

They are expected to be taken ashore later today.

The journey can be dangerous in the best of weather, but seas early on Monday were choppy.

Home Secretary Priti Patel has put in a formal request to the Ministry of Defence for help blocking migrants from crossing the Channel.

Her renewed efforts to prevent the dangerous crossings comes after more than 677 people made it to the UK in a surge of crossings between Thursday and Sunday.

More than 4,000 migrants have crossed the Dover Strait this year.

At least 65 migrants made it to the UK on board four boats on Sunday, the Home Office said.

Ms Patel has appointed a former royal marine as her clandestine Channel threat commander in a bid to clamp down on the illegal crossings.

Royal navy warships could be sent to block the migrant crossings, despite warnings many could drown.

Speaking to the BBC this morning, Care Minister Helen Whately defended the Government's plans to involve the Navy in preventing the crossings.

She said: "We need to bring this to an end.

"The Home Secretary's determined that this will not be a viable route to the UK and my colleague, Home Office Minister Chris Philp, is going to be in Paris later this week to talk directly with the French government about working together to stop this transit."

Immigration minister Chris Philp will head to Paris on Tuesday to hold talks with his French counterparts on the issue.

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UK migrant crisis: RAF patrols coast as Border Force intercepts dinghy with 20 migrants - Express

As Crisis Grows, Farms Try to Balance Health of Field Workers and Food Supply – Kaiser Health News

KNOXVILLE, Tenn. Its a busy time for the tomato-producing farms in this part of the state. Farms have staffed up with hundreds of workers, most of whom are Latino. Some live locally. Others are migrant workers who travel from farm to farm, chasing the summer growing seasons. Still others come from Mexico or Central America on temporary agricultural visas to work at certain farms.

But, this year, the season is taking place under a cloud of coronavirus worries that, for these agricultural workers, hit close to home.

Almost every part of the process for picking tomatoes needs to be considered in light of COVID-19, said Ken Silver, an associate professor of environmental health at East Tennessee State University, who studies migrant worker health on Tennessee tomato farms.

After all, the workers live in close quarters, sleeping in bunk beds, and sharing bathrooms and kitchens. They ride crowded buses to fields and often work in groups. And even though farm employees are deemed essential workers, they often dont have health insurance or paid sick leave.

Farms have already reported outbreaks among hundreds of workers in states that include California, Washington, Florida and Michigan. And yet, the federal government has not established any enforceable rules either to protect farmworkers from the coronavirus or to instruct employers what to do when their workers get sick. While migrant worker advocacy groups say this allows farms to take advantage of their workers and increase their risk of exposure to the coronavirus, farms say theyre doing what they can to protect workers with the limited resources they have, while also getting their crops harvested.

The situation certainly isnt clear-cut, said Alexis Guild, director of health policy and programs at the advocacy group, Farmworker Justice.

Leaving It Up to the Farms

In June, 10 temporary workers out of about 80 at the Jones & Church Farms in Unicoi County, Tennessee, tested positive for the coronavirus. Another farm in that county had 38 workers test positive around the same time.

This was the scariest thing that could happen, said Renea Jones Rogers, the farms food safety director.

Nationally, there have been at least 3,600 cases of farmworkers testing positive for COVID-19, according to media reports gathered by the National Center for Farmworker Health.

Add to this that farm employers and workers alike acknowledge that even the most basic interventions to stop transmission social distancing and mask-wearing often arent feasible, especially in the hot temperatures.

Saul, 52, is a temporary farmworker who has traveled from Mexico to Virginia every year since 1996 to harvest tobacco. In a WhatsApp message interview, he said masks are uncomfortable on the job because he is working outdoors, writing in Spanish, En el trabajo es incmodo porque trabajamos al intemperie. (Kaiser Health News is not publishing Sauls last name so that he wont be identified by his employer.)

Saul said he does worry about the coronavirus, but because he lives at his job on the farm, he feels safe.

When he arrived in the U.S. in April, the farm provided him with information about the pandemic, masks and hand sanitizer, he said. Nobody takes his temperature, but he works in a crew of eight, lives with only three other workers and nobody on the farm has yet been diagnosed with COVID-19.

In Tennessee, the Jones & Church Farms put its own worker safety protocols in place at the beginning of the season. These included increasing sanitation, taking daily temperature readings and keeping workers in groups so they live and work with the same people.

After the 10 workers tested positive for COVID-19, the farm kept them all in the same housing unit and away from the other workers but those who were asymptomatic also kept working in the fields, though they were able to stay away from others on the job, said Jones Rogers.

While the Department of Labor has not offered enforceable federal safety standards for COVID-19, it did collaborate with the Centers for Disease Control and Prevention to publish a set of voluntary, agriculture-specific guidelines. Those were released in June, just days after Jones & Church became aware of the farms outbreak.

Much of what had already been done at Jones & Church, though, tracked closely with those recommendations, which also suggested that workers be screened every day for COVID-19 symptoms and that those who become sick be given their own space to recover apart from others.

Other suggestions in the CDC and Labor Department directive, geared more toward indoor food-processing factories such as tomato-packing plants, included installing plastic shields if 6 feet of distance isnt possible between workers, putting in hand-washing stations and providing personal protective equipment or cloth face coverings.

Advocates say these guidelines are sound, in theory. Their glaring flaw is that they are voluntary.

We dont believe that the health and safety of workers should be left to the goodwill of employers, said Mara Perales Sanchez, communications coordinator for Centro de Los Derechos del Migrante, an advocacy group with offices in both Mexico and the U.S.

A Department of Labor spokesperson offered a different take. Employers are and will continue to be responsible for providing a workplace free of known health and safety hazards, the spokesperson said, adding that the Occupational Safety and Health Administrations preexisting general-safety standards and CDC guidelines are used to determine workplace safety violations. OSHA is an agency within the Labor Department.

Farm industry groups are apprehensive of any increased federal regulation.

I dont think OSHA would be able to have some sort of mandatory regulation that wouldnt disadvantage some farmers, said Allison Crittenden, director of congressional relations for the American Farm Bureau Federation.

Farms have already put many COVID-19 protections in place, she said, and if these actions are taking place in a voluntary way, we dont see that we need to have a mandatory requirement.

Difficulties in Accessing Health Care

Migrant farmworkers, despite occupying an essential link in the countrys food supply chain, often arent provided with workplace benefits like health insurance or paid sick leave.

Saul, the Virginia tobacco farmworker, said he didnt believe he has any health insurance. If he gets sick, he would need to tell his farm employer, who would then have to drive him to the doctor. The closest city to the farm is 15 miles away. Who is responsible for these costs the worker or the farm depends on individual circumstances.

Many farms employ mostly Latino workers, and CDC data illustrates that its much more likely for Hispanic or Latino people to be infected, hospitalized or die from COVID complications than white people. Experts also warn that because the COVID pandemic is disproportionately affecting people of color, it could widen preexisting health disparities.

Also, seeking a doctors care can feel risky for migrant farmworkers. Workers who are undocumented may worry about being detained by Immigration and Customs Enforcement, while workers who have green cards may be concerned about the Trump administrations public charge rule. This controversial rule weighs immigrants use of public programs, including health care, against their applications for citizenship. However, the federal government has said seeking treatment for COVID-19 wouldnt fall under the rule.

And while contact tracing is important to stop the spread of COVID-19 among farmworkers, many health departments dont have translators on staff who can speak Spanish or Indigenous Central American languages, nor has there been a systematic nationwide tracking of farmworker outbreaks thus far, as has been done with long-term care facilities outbreaks.

So its really hard to get a grasp on how many farmworkers specifically are testing positive, said Guild, with Farmworker Justice.

That could be an issue for tracing outbreaks, especially as the harvesting season ramps up for certain crops and farms bolster their workforces.

At the end of July, almost 90 additional temporary workers arrived at Jones & Church Farms to help harvest tomatoes through October, said Jones Rogers. Though the 10 workers who had COVID-19 have recovered, she said shes scared that if more get the disease, there wont be enough housing to keep sick workers separate from others or enough healthy workers to harvest the crops.

Tomatoes dont wait until everyone is feeling good to be harvested, said Jones Rogers.

Reporter Carmen Heredia Rodriguez and Katie Saviano provided Spanish translation assistance for this story.

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As Crisis Grows, Farms Try to Balance Health of Field Workers and Food Supply - Kaiser Health News

Hosting refugees and migrants Is a global public good – The Corner Economic

*This article was originally published by Fair Observer.

Diego Chaves & Olivier Lavinal | On June 20, we celebrated World Refugee Day. This was an opportune time for us all to pay attention to the challenge of forced displacement today. Strikingly, the world is facing the largest forced displacement crisis since World War II, with nearly 80 million people having fled their countries because of persecution, conflict, violence, human rights violations or events that have seriously disturbed public order. All continents now face forced displacement crises, and migratory problems cross state and community boundaries.

Forced displacement has hit Latin American and Caribbean countries particularly hard, highlighting existing vulnerabilities such as increased levels of violence and, more recently, the COVID-19 pandemic. Latin America is now home to one of the largest forced displacement crises in the world. As of March 2020, more than 5 million Venezuelans were reportedly living outside of their country, with 4 million of them in other Latin American countries: Colombia (1.8 million), Peru (1 million), and Ecuador and Chile (for a total of 1 million).

COVID-19 Arrives in Refugee Camp

Since the beginning of the Venezuelan crisis, most Latin American nations have tried to accommodate these recent arrivals, providing migrants with basic education, emergency health care services and legal status. These neighboring countries have provided a global public good by hosting millions at the risk of overwhelming their services and systems. But how will these nations be able to withstand the pressure?

Hosting countries face the new challenge of integrating larger numbers of migrants and refugees while dealing with the effects of the coronavirus outbreak. When taking into account that more than 60% of Venezuelan migration in Latin American countries is irregular and targets the most vulnerable populations, this crisis is now becoming a question of public health and safety and, ultimately, of regional security. It is time for the international community to provide a collective response that matches the magnitude of the crisis.

A first step was taken on May 26, with the virtual livestreamed on YouTube pledging conference for Venezuelan refugees and migrants that helped raise $2.79 billion in total commitments. This included $653 million of grant funding for the Refugee and Migrant Response Plan, which is a United Nations appeal to largely address the emergency needs of the migrant population.

The situation in Latin America calls for enhanced international support across the humanitarian-development nexus. In other words, the response should address pressing immediate needs such as temporary shelter and emergency medical services as well as the medium and long-term imperative of economic and social development through institutions, resilient local systems and service delivery. This is precisely what Colombian President Ivan Duque called for when advocating the shift from emergency response to medium and long-term development and integration.

Five Priorities

To help countries mitigate the impact of the crisis and charter a pathway to growth and stability, there are five development priorities to focus on.

First, new ways should be explored to provide regular status to refugees and migrants, including through targeted regularization or employment-based programs. There have been several efforts to provide regular status to recent refugees and migrants arriving from Venezuela.

Colombia, Peru and now Ecuador stand out for their ambitious regularization programs for hundreds of thousands of irregular refugees and migrants. Amid rising public anxieties over migration in some countries, it may become harder to implement such mass regularization programs or offer regular status to most who seek to enter. The approach followed by Colombia in providing regular status to those who have employment in specific sectors may provide another alternative. Similarly, Peru has been trying to regularize students in the countrys educational system another strategy that Colombia and Ecuador seem likely to adopt in the future and one that may prove more politically viable in some countries.

Yet these approaches risk leaving out the vast majority of recent refugees and migrants who do not attend school or work in the formal economy, or the families of those who do benefit from such measures. Policymakers should, therefore, be thinking about the medium and long-term effects where providing legal status to refugees and migrants would produce optimal labor market outcomes for themselves and the country overall. The details of implementation in each case will matter enormously, but there is room for reiterative efforts that focus on specific different groups over time.

Second, health care barriers should be tackled through clear policies on access and financing. Almost all countries in the region, at least in theory, offer emergency health care to immigrants regardless of regular status. Still, specific policies are often unclear, and measures are not always implemented effectively at the local level, which means that migrants often have difficulties accessing health care in practice. In countries where local and regional governments pay part of health-care costs, financial burden sharing is also often unclear, leading local hospitals to cover costs that may never get reimbursed.

Creating clear policies and procedures defining both the services offered and what amount of costs will be covered and by whom are critical. In some countries, such as Colombia, Peru and Costa Rica, where residents need to enroll in the health care system to be eligible for benefits, it is vital to find agile ways of ensuring that new immigrants can register and sometimes to find ways of covering the costs of their care.

Third, access to education should be improved through flexible enrollment practices and ongoing support. One of the most critical decisions of countries has been to offer primary and secondary education to all students regardless of their status. In some countries, this was already embedded in the constitution, but others have more recently adopted these measures.

This helps avoid a generation of young people growing up without education and supports receiving countries to take advantage of the potential human capital of immigrant children who will likely grow up in their territory. In many places, however, strict registration requirements involving documents that are difficult for migrants and refugees to obtain can prevent some from enrolling their children in school.

There is also an urgent need to work with schools on policies, procedures and curricula to facilitate the integration of Venezuelan children, who may face challenges adapting to their new schools and need additional support to develop critical skills (e.g., history, culture and other country-specific knowledge). In several countries, access to college, graduate education and trade schools is also restricted for those who do not have adequate documentation, which risks wasting the human capital of immigrant youth who aspire to enter professional and technical careers, including in fields that are in demand in their new countries.

Fourth, migrants skills should be unlocked to boost labor market integration and local economies. The majority of Venezuelan adults suitable for paid work in countries across the region were already working before COVID-19. In fact, more than 90% of Venezuelan migrants in Peru and 8 in 10 Venezuelan migrants in Colombia were employed before the pandemic. While recognizing that the labor markets of many countries in the region are characterized by a high degree of informality, care should be taken to ensure that immigrants do have pathways to better-paid and more stable employment in the formal economy and to avoid creating conditions where employers can pay immigrants less than the prevailing wage, to the detriment of both newcomer and native-born workers.

There is no more important determinant for long-term positive labor market outcomes than ensuring regular status, which helps immigrant workers improve their wages over time and also helps avoid unfair wage competition between native-born and Venezuelan workers. Refugees and migrants tend to be relatively well-educated, which means that there is a wealth of highly skilled human capital that could benefit receiving countries.

To effectively leverage this potential, countries will need to create agile ways for immigrants to get professional and technical degrees earned in their home countries validated and recognized by employers. Argentina has done this through provincial universities, which has allowed the country to encourage professionals to leave the capital and settle in other provinces where their skills are in demand. Creating expedited credential recognition pathways for applicants willing to settle in an area of the country where their skills are most needed could also help fill labor market gaps.

Fifth, constructive narratives about immigration should be developed to highlight opportunities while not ignoring its challenges. There is no question that the sudden outflow of 5 million Venezuelans constitutes a migration crisis, and one that host countries are keenly aware of. But this migration is also an opportunity for host countries, as illustrated by increased predictions by the World Bank of regional future economic growth as Venezuelan immigration drives labor market expansion.

Immigrants, when they have access to legal status, education, health care, financial services and pathways to validate their studies, tend to become net contributors to innovation, entrepreneurship and economic growth over time. Several governments in the region have gone out of their way to maintain their focus on these long-term opportunities, even while dealing with the challenges that the sudden arrival of so many people creates for already overburdened public services. Policymakers require assistance to orient the public debate on migration by keeping an eye on the medium and long-term benefits (and designing policies to help attain them). Still, they must also acknowledge the real strains involved in dealing with sudden, large-scale inflows.

Inclusive Development

This requires moving from emergency responses to long-term development and integration. While there is still a critical need for emergency services for recently-arrived migrants from Venezuela, as crises in these countries stretch on, it is also important to plan for the medium and the long term. The most important question in the future will be how to support inclusive development that can help host communities and immigrants build connections and improve their livelihoods together. Enhancing access to and quality of schools, health care facilities, housing and urban infrastructure in areas where migrants settle is vital. This is the key to successful integration and also an opportunity to turn a migration crisis into a net benefit for host societies.

While there is some need for temporary shelter and emergency medical services that international actors could help meet, the greatest needs for support have to do with building local capacity for integration and service provision both to new arrivals and long-time residents. For this, multilateral organizations like the World Bank should continue to be actively engaged in helping better manage the forced displacement crisis, in support of its mission to reduce poverty and contribute to achieving the UN Sustainable Development Goals.

*This article was originally published by Fair Observer.

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Hosting refugees and migrants Is a global public good - The Corner Economic

Bishop goes toe-to-toe with caller over refugee crisis – LBC

8 August 2020, 16:24

This caller insisted that migrants crossing the Channel to the UK aren't desperate, despite a Bishop telling LBC how these people find themselves in a dire situation.

Bishop Stephen Lowe is a former adviser to the Archbishop of Canterbury and was speaking to Ian Payne about the migrant crisis after over 200 people were intercepted crossing the English Channel in one day.

Paul phoned in from Liverpool to challenge the arguments of the Bishop, who called for Brits to be compassionate towards people making the perilous journey across the Channel as they flee war and famine in their own country.

"How do you make out these people are desperate," he asked Bishop Lowe. The Bishop maintained that you'd have to be desperate if you're crossing one of the busiest shipping routes in the world in a rubber dinghy.

Paul kept the pressure up, asking Bishop Lowe "what do they get here that France doesn't give them," to which the Bishop countered that people have "friends and relatives and so on that they know," referencing the large Iraqi and Syrian communities in the UK.

Ian stepped in momentarily, asking Paul what would he do." He insisted that he wouldn't have a problem with refugees if "they weren't given close to four star hotels to stay in."

"They should be processed in the place they've stayed the longest in," he added. Challenged on the hotel remark, Paul said that he has witnessed migrants being housed in hotels in Chester.

"300 miles from the port?" Bishop Lowe quipped. Paul insisted the Bishop did his homework on the subject.

Paul added that he has housed refugees in the past, to which Ian replied "I thought you'd have more sympathy." The caller said that he has sympathy for those fleeing war and famine, but not economic migrants.

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Bishop goes toe-to-toe with caller over refugee crisis - LBC

‘We can enact the future we want now’: a black feminist history of abolition – The Guardian

At an event held in honour of Malcolm X in 1982, Audre Lorde delivered an address titled Learning from the 60s, during which she proclaimed, Revolution is not a one-time event. By this, Lorde meant that revolution belongs to everyone and no one simultaneously; if it is to proceed, it must cease to be the sole and particular province of anyone particular race, or sex, or age, or religion, or sexuality, or class. Revolutions reoccur: they follow each other, making circles of time and all the political demands that push them forward.Lordes statement makes clear the purview of the black feminist tradition; nothing must be allowed to remain. We must be prepared for the multi-purpose, multi-layered revolution, in which political ideologies and mantras will, and must, collide.

The word abolition, most commonly understood to describe efforts that sought a legal end to chattel slavery, has a complex history. Many white advocates who deployed the term in the height of the abolitionist movements of the 18th and 19th century were not actually interested in the material emancipation of black life. Aphra Behns 1688 novel Oroonoko, for example, intended to awaken the English middle-class to the horrors of slavery, while employing a number of deeply racist and dehumanising tropes to do so.

But abolition as we know it now, developed through the black feminist tradition, owes everything to imaginative potential. It is a belief in emancipatory forms of social organisation and an end to all forms of violence, expropriation and exploitation. As prison abolitionist Ruth Wilson Gilmore writes, abolition is about presence, not absence; prison abolition, as one example, is about abolishing the conditions under which prison became the solution to problems. Prison abolitionists argue that carceral systems like prison, policing and detention are dangerous and wholly inadequate responses to crime that merely perpetuate the harm they claim to end. They are critical of ways of thinking that root wrongdoing in the individual, arguing instead that the social causes of crime require social solutions, beginning with an improvement of the conditions of life for all - free education, housing provision, healthcare and investing in community self-governance. Abolitionists believe that racist systems of police and prison do not keep us safe and that they should not simply be reformed in an attempt to improve them, but abolished altogether.

The desire to abolish police and prisons can be traced in grassroots black feminist traditions across the world. In the 1970s and 80s in the UK, organisations such as the Organisation of Women of African and Asian Descent (OWAAD) and the Brixton Black Womens Group, home to coalitions between black women and women of colour, campaigned against flagrant police violence and abuses of stop and search powers. Nicknamed SUS laws, these clauses enabled police officers to justify arrest solely on the basis of suspected intent to commit a crime. It is near impossible to ignore the legacy of such a law in the disproportionate searching, brutality and imprisonment of black people in the UK. In Heart of the Race, Black Womens Lives in Britain, authors Beverly Bryan, Stella Dadzie and Suzanne Scafe write: Even when our children were at school, we could expect the police to be called into the playground to break up fights it was as a result of these experiences of racist police force that black women began to organise against specific incidents of abuse and against legislation.

Kinship and community is how we keep each other safe when the state and racist institutions fail us

The actions of these feminist groups were prototypes for networks of mutual aid, like those that have emerged since the onset of the pandemic; they modelled what community power that sought to render the police irrelevant could look like. These women knew, as Stuart Hall writes, that race is the modality through which class is lived and their experiences as members of the working class were constituted and compounded by the systemic racism that locked them out of state protection and limited their access to resources.

The killing of George Floyd at the hands of Minneapolis police propelled abolition into the mainstream. Those of us who remember the eruption of protests, demonstrations, and organising around Black Lives Matter that took place in the UK in 2015, and who know the names of Joy Gardener, Cynthia Jarrett, Rashan Charles, Christopher Alder and so many more victims of racist police violence, feel the need to challenge the reductive view that this is only a US problem. SoRevolution is not a one-time event, a programme convened by Che Gossett, Sarah Shin and myself in collaboration with Arika and hosted by Silver Press, will attempt to understand and amplify abolitionist demands in this moment by bringing artists, organisers and academics together, and provide a space for reflection and political animus.

Our event The Masters Tools Can Never Dismantle the Masters House: Abolitionist Feminist Futures, to be chaired by academic and organiser Akwugo Emejulu and featuring academic Gail Lewis, critic Hortense Spillers, writer Zoe Samudzi and trans activist Miss Major, will explore abolitionist futures. In her work analysing black womens presence and absence in public discourse, Lewis calls to Sarah Reed, a black woman with complex mental health issues who died in Holloway Prison in 2015 after being failed by mental health professionals and prison staff. But if she is present, how is she here? / Only as: brutalised black woman... / Only as: a mentally unwell black woman? Understanding Lordes idea that the masters tools will never dismantle the masters house means recognising that the system that locked Reed away will never set others like her free. This is the first step in dismantling ideas that a broken system can be fixed via law, police and prison reform.

The intimate realm is an extension of the social world so to create other networks of love and affiliation is to be involved in the work of challenging and remaking the terms of sociality writes Saidiya Hartman, a participant of the second panel, Poetry is not a Luxury: The Poetics of Abolition. In 1985, Lorde wrote, Poetry coins the language to express and charter this revolutionary awareness and demand, the implementation of that freedom. If poetics is the study of the creation, production and art of making meaning, then we must understand its role in revolution. Hartmans work directs the readers eye to the anarchic posture of black life and community, to the power of revolution lived at the register of the everyday. Her fellow panelist Christina Sharpe continues this tradition in her book In The Wake, in which she refuses to treat images as static archival memorabilia. She analyses black persistence and survival in the face of the processes that render black people outside subjects.

What does abolition mean in the age of the internet? Using coding, hacking and other means of online sabotage to make it harder for the police to target vulnerable people. Glitch is a necessary erratum, a site of positive departure, writes Legacy Russell, author of Glitch Feminism and chair of the panel System Errors: Abolitionist Technologies and Aesthetics. Through cyberfeminism, we can make ourselves unknowable in order to outsmart the logics of surveillance capital. Currently, law enforcement is using all manner of digital practice including photography and Instagram posts to track down and charge protesters. Technology must be harnessed to both liberate and obscure blackness; to strip the digital image of its power. British artist and panellist Danielle Brathwaite-Shirley does this in their work, building a video game-like space online that visitors must navigate to evade the threats that black trans people face everyday. This panel will explore how the current matrix of violent governance takes place through physical and digital forms of dispossession and must be fought on both grounds.

The last panel in this programme, Happy Birthday, Marsha! held on the birthday of black trans campaigner Marsha P Johnson centres on care. Abolitionist modes of thinking encourage us to discover new forms of intimacy, speculation and kinship by encouraging community building with those outside our immediate family. That is how we keep each other safe when the state and racist institutions fail us. Despite its complexity, at its most basic, abolition is about enacting the future we want now and refusing to let anyone tell us it is impossible.

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'We can enact the future we want now': a black feminist history of abolition - The Guardian

Emancipation Day A Reminder That Caribbean Still Needs Justice, Repair – Human Rights Watch

On August 1, Anglophone Caribbean nations commemorateEmancipation Day, marking the 1834 abolition of slavery in the British Empire and the 1838 abolition ofapprenticeship, a system which forced formerly enslaved people to continue to work uncompensated for their former masters. Emancipation wasnot a gift. The Slavery Abolition Act, which banned slavery in the British colonies, followed a shift in the British Empires economic interests and sustained resistance by enslaved people through massive slave revolts, likeBussas Rebellionin Barbados, andguerilla warfare, as in the case ofJamaicas Maroons.

While resistance helped pave the way for emancipation in the 1800s, the Caribbean was not free from British colonial rulefor another century. For centuries, Caribbean people fought for liberation from slavery and colonization. Today, amid new calls for the UK to tackle systemic racism and reckon with the crimes of the British Empire, Caribbean people are still fighting for justice and repair.

On July 6, the Caribbean Community (CARICOM) Reparations Commissionreignited calls for reparationsfor slavery and colonization, emphasizing the impact of the legacy of British colonialism on life and legislation in the Caribbean today. The Commission, established in 2013 to prepare the legal and ethical case for reparations payments for CARICOM member states, lays out a 10 point plan for European former colonial powers to provide reparatory justice for slavery and colonization. The first step in the Commissions plan is a formal apology for slavery. To date, the UK has expressed deep regret for its role in the Trans-Atlantic Slave Trade, but has never formally apologized. A full apology is an important step, not only for atonement, but also because it is an opportunity to acknowledge and examine the contemporary effects of the British Empires abusive practices in the Caribbean.

British slave traders kidnapped an estimated3.1 million peoplealong the west coast of Africa,trafficked them across the Atlantic Ocean, and subjected them toforced labor and tortureon the colonialplantationsthatenriched the British crown. British colonial legislation codified racial difference between the white planter class and enslaved Africans, and regulated slaves behavior through harsh slave codes. Slaves were denied access to land, education, or any means of social and economic advancement. CARICOM Reparations Committee chair Professor Hilary Beckles has noted how severe neglect by British colonial authorities of the human development of Black populations in the Caribbean led to rampant illiteracy and serious health issues across the region, which continued after emancipation.

Black populations in the Caribbean were also denied political and economic autonomy. Under British colonial law (as in the United Kingdom until the early twentieth century), the right to vote was predicated on a mans wealth and land ownership. In the Caribbean this effectively excluded the poorer, landless Black majority from voting for more than a century after emancipation. Without the right to vote in elections, Black populations were subjected to the legislative whims of the white upper classes and denied representation in government without the ability to hold political authorities accountable. Universal Adult Suffrage in the Caribbean was not achieved until 1944, first in Jamaica, and then spreading to other Caribbean islands between then and 1962.

Colonial legislation safeguarding the wealth of the white British planter class, through the control and violent exploitation of Black African labor, cemented the deep racial and economic inequality that persists across the Caribbean today. In Barbados, for example, formerly enslaved people and their descendants were excluded from purchasing land under the colonial Contract Law. The effects of the law continued after independence and by 1970, an estimated 77% of land in Barbados rested in the hands of the wealthiest 10% of the countrys landowners.

Some British firms that were enriched by the Trans-Atlantic slave trade have apologized, and some, like insurance company Lloyds of London, have agreed to make financial contributions to organizations supporting Black and ethnic minority communities. The British government, however, has previously dismissed and derailed calls for reparations for slavery and colonization. In 2001, the British delegation to the Durban Conference on Racism, Racial Discrimination, Xenophobia and Related Intolerance blocked an outright apology for slavery by the European Union, despite support for the apology from some other European delegates.

During a 2015 visit to Jamaica, former UK Prime Minister David Cameron rebuffedcalls by the Jamaica National Commission on Reparationsfor the UK to pay Jamaica reparations, stating the country should move on. Instead of reparations, Cameron announced that the UK would spend25million pounds to build Jamaica a new prison. Camerons offer was particularly pernicious considering the history ofunlawful detentionandexcessive use of force by the Jamaica Constabulary Force, which isheavily influencedby colonial lawsdesigned to enforcea racist and exploitative colonial social order.

The British empires brutal trafficking and abuse of enslaved Africans throughout the Caribbean, and the continued exploitation of their descendants during colonialism, helped form thebasis for the mercantile wealth that built modern British society. Despite this, Caribbean people have been routinely denied remedy for past injustices, and continue to feel the effects of colonization as well assuffer abuses at the hands of the British government in the United Kingdom today.

As we commemorate the end of slavery in the Caribbean, we must not forget that the region is still in need of justice and repair. If we are truly to move on, the British government should acknowledge the extent of abuses committed during slavery and colonization and begin the conversation on the contemporary ramifications of past harms by the British Empire.

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Emancipation Day A Reminder That Caribbean Still Needs Justice, Repair - Human Rights Watch

Blended Capital For Immigration Bonds: Introducing The Freedom100 Fund – Forbes

FFI staff & volunteers with friends from J.M. Kaplan Fund.

While finance to many might conjure a boring system of transactions or a dangerous game of capitalist exploitation to financial activists, investment vehicles are fair game for creative and exciting innovations toward liberation. One area of continuous advocacy is the abolition of bail, which forces countless individuals to remain in jail simply because they cannot afford their own release. Often, the over-incarcerated and their loved ones have to turn to bail bonds companies that exploit the vulnerability of their financial situations, charge exorbitant interest, and require collateral in exchange for the funds needed for bail. According to the Prison Policy Institute, over 465,000 people are held in local jails every day without being convicted of a crime, simply because they cant afford their bail.

Bail isnt just part of the criminal justice system you might be surprised to hear that it exists in the immigrant detention system, too. Except that in this context, its referred to as immigration bond. Thats right, take a second to wrap your head around this: despite committing what should be a civil, not criminal, infraction, immigrants who cross the border seeking a better life are asked to pay bond. Tens of thousands of children and adults are in this position on any given day, stuck in immigrant prisons and jails for years. With the costs of bonds ranging from $1,500 to $250,000, immigrants and their families often cannot afford to pay bond.

Numerous bail funds like the Bail Project, New Yorks Free Them All for Public Health, and LAs Peoples City Council Freedom Fund have historically helped address the criminalization of poverty in the U.S. and advocates have been working to end cash bail entirely. In the wake of mass arrests of protestors around the country in support of the Movement for Black Lives, many bail funds have experienced an unprecedented surge in financial support. But there has been less attention on immigrant detention. Thats where Freedom for Immigrants has stepped in. Since 2010, they have supported both bond funding and critical post-release wraparound services for immigrants nationwide. Their National Hotline, the nations largest for immigrants in detention, receives between 600 and 14,500 calls per month. They are part of a growing network of bail and immigration bond funds across the country, hosted by Community Justice Exchange.

Freedom for Immigrants is a national nonprofit that has grown from monitoring the human rights abuses faced by immigrants detained by ICE through their national hotline and network of volunteer detention visitors to also include actionable approaches for dignity, not detention. These approaches call for divestment from for-profit incarceration and investment in community-based organizations and tools like bond funds to welcome immigrants into the social fabric of the United States. The organization is now partnering with Mission Driven Finance an impact investment firm and certified B Corporation dedicated to using finance as a tool for change, expanding access to capital, and closing opportunity gaps to launch the Freedom100 Fund. This new pilot fund aims to release 100 individuals from immigration prison, support them with their cases and prove that its time for the bail and bond system to go.

I talked with Lauren Grattan, Co-Founder and Chief Community Officer of Mission Driven Finance, and Christina Mansfield, Co-Founder and Co-Executive Director of Freedom for Immigrants, to learn more about this bond fund, how it works, and why its an important development for investors and activists committed to immigrant freedom.

For those who may be new to this world, whats the current problem with immigration bonds and the criminalization of poverty in the United States that you're trying to address? How has COVID-19 added another layer to this?

Gretta Soto Moreno, member of FFI Leadership Council.

CM: On any given day, thousands of immigrants are locked up in prisons and jails as part of the U.S. immigration detention system. The system is composed largely of people who are either newly arrived, such as asylum seekers, or those individuals who have longstanding ties to their communities here in the U.S.

Individuals who flee their home countries to seek refuge in the U.S. and claim asylum at a port of entry have been subject to mandatory immigration detention since at least 1996 as a result of harsh policies signed into law by President Clinton. Those same laws expanded the list of aggravated felonies for which people like Legal Permanent Residents and others could be detained and made subject to deportation, including many non-violent offenses. Around that same time period, a series of tough on crime laws were passed that further criminalized communities of color. As a result, since 1996, there has been a dramatic increase in the number of people who have been sent to ICE detention.

Its also important to recognize that throughout this period of time the federal government has increased its use of criminal prosecutions for people migrating. The federal government considers illegal entry a misdemeanor while illegal re-entry is considered a felony. The family separation crisis grew out of these policies, forcing families to be split up needlessly and inhumanely.

COVID-19 has added another layer of complexity and urgency to the situation. Freedom for Immigrants and other partners are focused on helping to bond out people who are immunocompromised and medically vulnerable. We are also submitting parole requests for the release of people without paying cash bonds, but the federal government is only granting a small number of these requests. In addition, Freedom for Immigrants is tracking abuses related to the pandemic and the organized responses of people inside on this real-time map.

How did Freedom for Immigrants and Mission Driven Finance decide to collaborate on this new initiative, using money as a tool for social change rather than a weapon for exploitation?

LG: When we met Freedom for Immigrants and grasped the size and severity of the issue of immigrant detention, we knew we wanted to support their incredible work rehumanizing a cruel system. Immigration is part of our daily lives in our hometown of San Diego, where we have the most active land border crossing in the country and one in four San Diegans are born outside the U.S.

CM: At Freedom for Immigrants, we know human rights and immigration policy really well, but innovative finance is not our strength. It was critical to find our partners at Mission Driven Finance as they fully believe in our vision and worked within our ethical framework to co-create this fund expanding our national detention bond program.

LG: We partnered with Freedom for Immigrants to develop the Freedom100 Fund a first-of-its-kind opportunity to finance bonds and release 100 people from immigration detention across California and Louisiana at no cost to the individual. Once bonded out, individuals are eight times more likely to win their immigration cases. But without the ability to pay a bond, many individuals are forced to languish in immigration detention and away from their loved ones and communities and forced to navigate complex legal proceedings on their ownoften in a language that is not their first.

As more people have been detained and the costs of immigration bonds have skyrocketed (the median bond in California and Louisiana is $8,500), families and community groups that previously donated money to bond out their loved ones are now strapped for cash. This is a perfect space for impact investing: Amplifying limited philanthropic dollars.

CM: We chose California and Louisiana because they represent some of the best and worst jurisdictions for immigrants to win their cases, respectively. In Louisiana, 87.8% of all immigration detention cases are denied, whereas only 52.2% of cases in California are denied. By bonding out individuals in these two states, connecting them to supportive resources, and helping them make all their court appearances, we can demonstrate that the practice of detention isnt just inhumane and wildly subject to political bias its unnecessary.

So how does this fund actually work and what is the ultimate goal?

LG: The Freedom100 Fund is designed to extend the impact of donated dollars. In a nutshell, instead of making donations directly to post bonds, donors make grants into a reserve account that absorbs some of the risk to make the opportunity more attractive for private investors who might not have financed immigration bonds otherwise. The fund is structured to leverage $500,000 in the philanthropic reserve account at least four times, unlocking $2M of investor capital and ultimately expand the availability of rapid, free immigration bond financing.

The fund lends to Freedom for Immigrants to have the money to post bond directly at ICE field offices on behalf of 100 individuals. As individuals go to their immigration court appearances and get their cases resolved (positively or negatively), the Department of Homeland Security (DHS) repays Freedom for Immigrants which would then repay the fund.

We need every tool in the toolbox, including finance, to make a more just world. Our hope is that the Freedom100 Fund can provide dignity and care for 100 individuals immediately and hopefully scale to serve thousands. We also want the fund to serve as a model for how innovative finance can move the needle on some of our most difficult social and environmental challenges and quickly. The first capital from the fund flowed to Freedom For Immigrants earlier in July and theyve already bonded out eight individuals.

Why is this bond fund an impact investing fund instead of just a philanthropic effort?

LG: As an investment firm, we like to right-size the tool to the problem. Philanthropy makes a lot of sense for proving early on that a program can work, for subsidizing programs that dont have a functional market, and for taking on riskier financial positions to unlock other capital. But to fully address problems of this size, we have to mobilize more than just philanthropy.

Thanks to their donors, Freedom for Immigrants has built a successful detention bond program and critical case management support. And now donors are committing to that third scenario of unlocking other capital because they need more money in this fight than donations alone.

We always look for repayment pathways to see if impact investing is possible. As strange as it is, the fact that DHS repays bonds at the conclusion of immigration trials gave us the opportunity to explore an investment strategy with Freedom for Immigrants. Because of this fact, we were able to build this structure without burdening immigrants or their families, unlike most other bond financing. Its a highly unusual revenue source, but it is a revenue source!

If this system is so wrong how do we end it, as opposed to financing it? Clearly the Freedom100 Fund can help get people out of detention centers now a critical outcome but is it also enabling the system?

CM: This is a critical question we must continually ask ourselves as abolitionists. Freedom for Immigrants combines direct services to people in immigrant prisons and jails with policy and advocacy to end the system completely. When we decide on the scope of our work, we always ask ourselves whether what we are doing could lead to the perpetuation of the system. The Freedom100 Fund is a great example of this calculus.

Our goal of the fund is twofold:

1) Secure the freedom of 100 individuals currently incarcerated only because they cannot afford to pay a bond; and

2) Leverage the model to advocate that the incarceration of immigrants in our detention system is entirely unnecessary and should be abolished.

Paying the federal government bond is working within an unjust system to alleviate the suffering of people now. But our goal is to prevent anyone from ever having to suffer incarceration. The government justifies the system by assuming that if immigrants are not imprisoned, they will abscond and risk becoming a public charge. The truth is, the immigration detention system itself is the biggest charge on the American public.

Our taxpayer dollars fund this profit-driven system, enriching local governments and private prison corporations at the expense of us all. This fund will demonstrate that people are imprisoned solely because they cannot afford to pay an immigration bond, but when we are able to finance their freedom they are able to concentrate on winning their immigration cases and comply with what the government is asking of them. We are advocating for divestment from inhumane systems of incarceration and investment in community organizations that support and welcome immigrants.

Finally, how can people get involved? Who can be an investor?

LG: Anyone can donate to Freedom for Immigrants, or consult with your financial advisor about whether it's appropriate for you to invest in the fund through a charitable vehicle like a donor advised fund at your favorite community foundation. While only accredited investors are eligible to consider a direct investment in the Freedom100 Fund, we encourage everyone to learn more about collectively ending immigration detention by visiting Freedom for Immigrants site.

Thanks to Jasmine Rashid for her contributions to this piece. Full disclosures related to my work available here. This post does not constitute investment, tax, or legal advice, and the author is not responsible for any actions taken based on the information provided herein.

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Blended Capital For Immigration Bonds: Introducing The Freedom100 Fund - Forbes

UWI economics from the 1970s (Part 1) – Jamaica Observer

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BSc (Econ) UWI: the sixth former in Kingston had scribbled this on the inside cover of his economics textbook, Intermediate Economics by J Harvey, in about 1977. This was an aspirational note. In the UWI system, after three years of post-sixth form studies, the degree could be his.

Naipaul's Primer

The aspiration was perhaps more practical and reachable than that scribbled by VS Naipaul at Queen's Royal College on his fourth form Latin primer to leave Trinidad in five years. Naipaul fell short by a year on his ambition, but he eventually assumed his cosmopolitan mantle. From under this mantle he elaborated on his schizophrenic relationship with his homelands, starting with the comic atmosphere of Miguel Street and The Mystic Masseur, but graduating to bitter ridicule and scorn in later years.

BSc (Econ) UWI circa 1978 was to be a passport not to lucre, but to learning, knowledge and, with good luck, probably to wisdom. And so, those embarking on the Mona experience did so armed with the view that studies in economics would be an avenue for both personal and professional advancement.

First year (1978)

In the first year of BSc (Econ) UWI, with classes frequently held in N1 of the Arts block (now the Neville Hall Lecture Theatre), the economics neophytes shared ideas with management students (in superior numbers), future sociologists, and budding political scientists.

The lecturers included the highly rated Ramjeesingh, in economics and in statistics, Dr Roach in mathematics, the thoughtful Rupert Lewis for politics, the perceptive Bernard Marshall for history on Mondays and Fridays at 5:00 pm, and two leading sociologists, Barry Chevannes and Don Robotham.

The first-year lecturers exposed students to dialectical materialism, The Labour Theory of Value, The State in theory and practice, Durkheim , The Protestant Ethic and the Spirit of Capitalism, Schumpeter and other ways of seeing. These other ways of seeing were, almost literally, new methods of understanding social and economic phenomena; for, at the high school level, neoclassical demand and supply curves, Keynesian macroeconomic principles and production possibility frontiers had been predominant on the Cambridge A' Level syllabus. Now, the student was challenged to put other instruments in the toolbox of socio-economic analysis.

Eurocentric?

Was the new toolbox too Eurocentric? In the first year there was steady exposure to Marx and other (mainly) 19th century writers in economics, politics and sociology; but there was also significant exposure to Caribbean scholarship of quality. Question 1 on the tutorial sheet for Introduction to Politics in 1978 was about Marcus Garvey: Garvey preached racial pride but the main point of his work was anti-imperialism. Discuss.

This was promptly followed by a question which required students to consider the role of the media in the Commonwealth Caribbean, with readings from Caribbean Quarterly and other regional sources. In addition to Caribbean Quarterly, the book Essays on Power and Change in Jamaica (edited by the illustrious pair of Carl Stone and Aggrey Brown) proved to be particularly stimulating. Especially stimulating too were politics tutorials under the experienced hand of Ann Spackman, who challenged all shortcuts European or otherwise and was said to be doctrinally opposed to giving 'A' grades, a characteristic rumoured to be shared with some senior denizens of the UWI History Department of the time.

It may have been in the Introduction to Politics final examination for 1978-79 that students were called upon to assess how, and to what extent, poor countries owe their underdevelopment to developed countries. This question, of course, was built on a premise constructed in part by Walter Rodney, the highly rated Mona historian who had been declared persona non grata by the Hugh Shearer Administration a decade earlier. The question, too, could have been connected to Tanzanian President Julius Nyerere who, on a celebrated, rain-bearing, visit to Jamaica in 1974 eloquently maintained that in international relations the poor remain poor because they are poor.

IMF bank?

For the following year, Question 1 on the Introduction to Politics final examination was, I think: Is the IMF a bank? The background to this question may have been a statement by Andrew Young, then the US ambassador to the United Nations. Ambassador Young, on a visit to Jamaica in 1977, argued that the International Monetary Fund, as a bank, had the right to impose conditionalities on Jamaica in return for their loans to the country in the same way that a bank would do to its debtors. Against a background in which BSc (Econ) students were reading Cheryl Payer's The Debt Trap: The IMF and the Third World, Young's analysis was the subject of much contention on the campus and presumably on the examination paper.

Eric Williams

Our history exposure in the first year was fundamentally and unapologetically Caribbean. Eric Williams' From Columbus to Castro and Capitalism and Slavery were on the top bookshelf. The former was rated for its broad view of developments in Caribbean history, readable style and its unexpected witticisms (Columbus fell on his knees and then on the Aborigines). And the latter, based in large part on Williams' doctoral thesis at Oxford, brought home to the sceptical, postcolonial reader the fact that humanitarianism and the work of the Saints were not the only factors in the abolition of the British Caribbean slave system.

Other history items on the top shelf were photocopied essays that included Roy Augier's path-breaking Before and After 1865, Elsa Goveia's New Shibboleths for Old, and Douglas Hall's presentation on the apprenticeship system in Jamaica (with planters 'squeezing the last ounce of juice' from the enslaved).

From the first year it was clear that the Caribbean authorities would not always agree with each other: New Shibboleths, for example, was a surgical critique of some aspects of Williams' work that must, at very least, have put the original prince of Port of Spain on the back foot for a few weeks. These and other offerings were consumed with pleasure, with students engaging in long arguments about how history should inform praxis.

Mathematics

BSc (Econ) in the second year took on a specialist tone and mathematics sat upon its throne. The student grapevine spoke unequivocally: Basic Mathematics for Economists was a misnomer. To begin with, basic maths involved differentiation and integration in calculus at a considerably more complex level than was required for mathematics and statistics.

So, in much the same way that the Jamaican Supreme Court is not really supreme, basic maths was not really basic. When the lecturer, Dr Roach, informed the class that the Kolmogorov-Smirnov test would not be appearing on our final examination paper, there was a loud chorus of relief throughout the lecture room (SR 4, Social Sciences).

Dr Roach was a methodical and quiet mathematician who never seemed perturbed by challenging questions. He was based full-time at the then College of Arts, Science and Technology (CAST) but offered his considerable skills to Mona students; in a small, developing society, sensible people are prepared to share knowledge and to acknowledge needs.

Statistical method

The realm of king mathematics also extended to Economic Statistics, Statistical Method, and Elementary Econometrics. Economic Statistics was taught by John Gafar from Guyana. Gafar lived for cricket, pointing out in his first class of the year that if Test cricket was being played at Sabina Park, students would not see him at Mona. This hypothesis was not tested. In the statistics courses, however, several economic hypotheses were subject to testing, at given degrees of freedom.

Students were also asked whether certain estimators were sufficient, unbiased or consistent; invited to reach precise, technical conclusions about variance, normal distribution and to evaluate probability using Chebychev's inequality, and other methods. A part question on the Statistical Method final examination for June 1981, in the pre-COVID-19 era, captures the flavour of the lecturers' expectations. Question 4 (a) read:

The probability that a person who is exposed to a certain contagious disease will catch it is 0.20. Find the probability that the 20th person exposed to this disease is the fifth one to catch it.

This was in all probability a question from the pen of the aforementioned Dr Roach.

In the book

For years before and after 1981, Professor Al Francis was responsible for guiding students through the pleasures and pains of Elementary Econometrics. As was the case with Basic Mathematics, there may have been a structural error in the naming of the course, for while econometrics was much in evidence, the adjective elementary was distinctly misleading. Prof was, however, a born teacher who gave us the intellectual tools to take on concepts such as ordinary least squares estimators, multicollinearity, dummy variables, and the Koyck transformation with confidence.

Prof Francis also gave students the will and the skill to guide themselves through difficult, technical material. If a student asked a question about an item not covered in lectures, Prof's first line of response with a smile was apt to be, But it is in Johnston read it and let me know how you get along, withJohnson being Econometric Methods, the assigned textbook. Prof, who had taken his doctorate at MIT, ensured that his econometric students were prepared to match the best in the world.

Al Francis

On top of Prof's expertise and pedagogical skills were layers of determination and modesty. It is reported that the young Al Francis opened the batting for Kingston College in his time playing Sunlight Cup cricket. His opening partner was Easton Bull McMorris who went on to captain Jamaica and open for the West Indies (as highlighted in recent editions of the Sunday Observer). And at one down on the KC side was Collie Smith, the legendary West Indian star batsman who left us early.

At very least, then, Prof batted with the stars and could make his own claim to cricketing greatness. He also represented the school at football, and his academic achievements took him to some of the most renowned institutions in the world.

And yet, Prof studiously avoided autobiographical comment to those within his charge. He was more inclined to talk about a book he had just finished reading, to discuss the mathematical principles behind autocorrelation, or to reflect on the need for better basic schools in Jamaica, than to elaborate on his life achievements.

The early 1980s saw Prof Francis leave the Department of Economics to go, for a time, to a senior position at the International Bauxite Association. There, he noted, the view from his office in New Kingston directed to the hills of St Andrew and further north was more impressive than that from his ground floor office on the corridor at Mona. But his heart was at Mona, and so, he returned home.

Coming next: Other lecturers and the times.

Ambassador Stephen Vasciannie is Professor of International Law, UWI, Mona.

Now you can read the Jamaica Observer ePaper anytime, anywhere. The Jamaica Observer ePaper is available to you at home or at work, and is the same edition as the printed copy available at http://bit.ly/epaper-login

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UWI economics from the 1970s (Part 1) - Jamaica Observer

The Interisland Travel Quarantine Is Coming Back, Oahu Beaches And – Honolulu Civil Beat

Following record new cases of COVID-19 statewide, Hawaiis governor and the Honolulu mayor are bringing back sweeping restrictions that were in place at the beginning of the pandemic and creating a special police unit to cite and arrest violators.

Starting on Tuesday, anyone arriving in Kauai, Hawaii, Maui or Kalawao counties will be required to quarantine for two weeks. The quarantine requirement does not apply to those arriving on Oahu.

Gov. David Ige said at a press conference Thursday afternoon that the quarantine rule would apply to all interisland travel, but his office later sent out a press release saying it will only affect travelers arriving in Kauai, Hawaii, Maui and Kalawao not Oahu.

Because of the surge in cases on Oahu, all the county mayors agree that additional measures are necessary to make sure cases do not spread uncontrolled across all counties, Ige said.

Mayor Kirk Caldwell is once again ordering the closure of island beaches and parks.

Cory Lum/Civil Beat

On Oahu, where coronavirus cases have surged, Mayor Kirk Caldwell has issued a new order called Act With Care Do Not Gather. It takes effect Friday at midnight and will be in effect until Sept. 5, he said.

All city and state beaches and parks will be closed again. They were previously closed from mid-March through mid-May.

There will be no activities allowed on the beach or in the parks, Caldwell said. You can traverse the parks to get to the water to surf, to swim, to paddle, to dive, fish and do other Native Hawaiian gathering rights but in the water. Not in the parks, not on the beaches.

Hiking trails in city and state parks will also be closed, although trails run by the Hawaii Division of Forestry and Wildlife will remain open, the Hawaii Department of Land & Natural Resources said on Friday. Spokesman Dan Dennison said the state park closures are necessary because many are adjacent to beaches, which are the areas where large groups have been congregating.

You dont typically see 100 people at a party out on the trail, he said in an email. I would add that if theres evidence of crowding and large gatherings on trails, additional closures would be considered. I remember State Epidemiologist Dr. Sarah Park saying that people who keep six feet apart on a trail, mask-up when passing, and limiting group numbers are likely at low risk.

Public restrooms and showers will remain open. Parking lots for parks where vote by mail deposit boxes are located will remain open through Saturdays primary election but will be closed after, Caldwell said.

Campgrounds and botanical gardens will be closed. All team sports are banned. City and private pools, including hotel pools, will be shuttered. Indoor businesses including bowling alleys, arcades and mini-golf facilities must cease operations. Private tennis clubs will be closed.

The park closures include the shuttering of playgrounds, tennis courts, dog parks, skate parks, the Koko Crater Tramway and the Peoples Open Markets, according to the Honolulu Parks and Recreation Department. Parking lots for scenic lookouts will be closed.

The goal is to eliminate large, uncontrolled gatherings, such as groups who congregate under tents at beach parks, Caldwell said.

Honolulu Police Department Chief Susan Ballard said dozens of police officers will be looking for COVID-19 rulebreakers.

Cory Lum/Civil Beat

Im sure youve seen it when youve gone to the beach on the weekend, he said. So, bright line, easy to enforce. Parks are closed.

Hawaii Department of Health Director Bruce Anderson said officials believe large outdoor gatherings may be contributing to the rise of cases, although he didnt cite any specific clusters.

We think thats one of the most likely sources of exposure for a lot of the cases where we arent able to identify other sources, he said.

The federal Centers for Disease Control and Prevention say the risk of COVID-19 transmission is much higher when indoors where space is tighter and ventilation is limited.

But some indoor businesses on Oahu will be allowed to stay open. Gyms, where contact tracers have identified COVID-19 spread, can continue to operate except for group classes, Caldwell said.

Restaurants can remain open, although staff members, including those in the kitchens, must wear masks. Hair salons, massage parlors, tattoo shops, spiritual services, museums, art galleries and movie theaters can stay open. Golf courses and the Koko Head Shooting complex will remain open, Caldwell said.

Whats open are things that we can control, Caldwell said. Where there is compliance and not uncontrolled gatherings, we feel we should not punish those folks and crack down where the problem resides.

Oahus new wave of closures follows last weeks shutdown of Oahus bars for three weeks. They had just reopened on June 19. Caldwell added that the city will shutter bars that are posing as restaurants.

The most important part of the order is enforcement, Caldwell said.

Honolulu has created a COVID enforcement team of 160 sworn police officers who will respond to reports of violations and patrol islandwide seven days a week, said Police Chief Susan Ballard, who also spoke at the press conference. Starting Sunday at 10 a.m., people can report violations to a new hotline at 808-723-3900 or online at HPDCOVIDenforce@honolulu.gov.

At this point, were probably going to do very few warnings, she said. Its going to be either citations or arrests.

Im just begging you, please, Ballard said.

We need to get our island open, she said. We need to get back to normal.

The chief noted that homeless people are not exempt from most of the mayors order. Anyone found in a closed city park can be ticketed or arrested, she said. A review of emergency proclamation citation data by Hawaii News Now found that prosecutors have been dismissing thousands of citations given to homeless people during the pandemic.

Nonetheless, Ballard said her officers will continue to issue them.

If theyre in the parks and theyre not supposed to be, they could get cited and possibly arrested, she said.

Ige said the new wave of restrictions is necessary so that COVID-19 patients dont flood the islands hospitals.

While our health care system has managed and can manage the current level of cases, the hospitals have warned that if the trend continues, we will begin to reach a critical point that can overwhelm the health care system, he said.

Department of Health Director Bruce Anderson said more COVID-19 deaths and hospitalizations are inevitable.

Cory Lum/Civil Beat

Anderson said it is alarming to see the spike in cases, including two deaths on Wednesday and 152 new cases Thursday. With the new cases come more hospitalizations and more patients in intensive care, he said.

We are approaching a health care crisis and bold measures are needed now to stem the increase and the spread of COVID-19 in Hawaii, he said. The current situation is actually much more serious than we projected when we anticipated increases as the state reopened.

Hilton Raethel, president and CEO of Healthcare Association of Hawaii, said Oahu hospitals are poised to run out of ICU bed capacity by the end of this month, a dire situation he said the state has never faced before.

Hawaii hospitals have contingency plans for dealing with a major health crisis. They include converting acute care beds which are usually used for people recovering from surgery or disease into ICU beds, which are designed for complex, specialized care. But no Hawaii hospital has ever had to put one of these plans in effect, Raethel said.

The problem is if the infection rate continues to grow we will not only exceed our current capacity, but we will blow through our expansion capacity as well, he said.

Then we will run the risk of facing those incredibly difficult challenges of who gets a bed, who gets a ventilator, who gets the drugs, who gets the care. We do not want to get to that point where we are literally facing life or death decisions about who gets care and who doesnt get care.

People gather near the Kapahulu Groin in Waikiki on Thursday. Beaches and parks as well as other outdoor venues will be closed beginning Saturday morning for the next four weeks in an effort to control the spread of the coronavirus.

Cory Lum/Civil Beat

All the ICU beds at Kaiser Permanentes Moanalua Medical Center were full yesterday, according to Raethel. The only way to turn this trajectory around is for the public to work together to slow down the infection rate, he said.

Efforts to hamper the spread of the virus will not yield lower hospitalization rates for another two weeks because of the time it takes for symptoms to develop. Neighbor islands are not in such dire circumstances right now because the infection rate is much lower, Raethel said. But he noted that the public health resources on neighbor islands are more limited.

As of Thursday, 117 people were hospitalized with COVID-19 in Hawaii 115 of them on Oahu and 54% of ICU beds are filled, Anderson said. About 10% of overall cases end up in the hospital, according to Anderson.

Community spread of the coronavirus on Oahu has already stressed public health infrastructure, including contract tracing efforts, Anderson said.

There will be more deaths and more hospitalizations in the weeks to come because of gatherings and other activities from crowding that occurred in previous weeks, he said.

Anderson noted it is especially tough to limit the spread of the virus in large, multigenerational households where its hard for people to isolate and stay home from work when theyre sick.

The governor did not provide any clarity on the plan to reopen schools or the University of Hawaii saying only that officials are working through the details.

We are looking at a number of things, he said.

Board of Education Chairwoman Catherine Payne said Thursday she expects more clarity in the next few days or by early next week about how the increase in COVID-19 case numbers will impact schools, particularly on Oahu.

The new school year is set to begin Aug. 17, through a mix of virtual learning and in-person instruction across the state. Teachers reported back to work on July 29.

I do not think we can afford to shorten learning any more, Payne said. Even if we do not have a perfect setup for distance learning for all students.

Civil Beat reporters Brittany Lyte and Suevon Lee contributed to this story.

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The Interisland Travel Quarantine Is Coming Back, Oahu Beaches And - Honolulu Civil Beat

The Jobs Recovery Is Not Yet Half-Way as Progress Slows – TheStreet

The BLS Employment Report for July shows employmentrose by 1.8 million in July following a gain of 4.8million in June, and 2.7 million in May. The unemployment rate fell slightly to 10.2%.

Initial Reaction

The Bloomberg Econoday consensus jobs estimate was +1.677 million and the unemployment rate consensus was 10.5%.

The BLS said that errors that plagued the household survey since March was not as bad this month.

BLS Error Rate

For March through June, BLS published an estimate of what the unemploymentrate would have been had misclassified workers been included. Repeating thissame approach, the overall July unemployment rate would have been about 1percentage point higher than reported. However, this represents the upperbound of our estimate of misclassification and probably overstates the sizeof the misclassification error.

According to usual practice, the data from the household survey are acceptedas recorded. To maintain data integrity, no ad hoc actions are taken toreclassify survey responses.

Add 1 percentage to unemployment rate for a better estimate.

Job Revisions

The change in total nonfarm payroll employment for May was revised up by 26,000, from +2,699,000 to +2,725,000, and the change for June was revised down by 9,000, from+4,800,000 to +4,791,000. With these revisions, employment in May and June combinedwas 17,000 higher than previously reported. (Monthly revisions result from additionalreports received from businesses and government agencies since the last publishedestimates and from the recalculation of seasonal factors.)

BLS Jobs Statistics at a Glance

Part-Time Jobs

Don't try to make sense of those numbers as they never add up. I list them as reported.

BLS Employment Report Statement

Total nonfarm payroll employment rose by 4.8 million in June, and the unemployment rate declined to 11.1 percent, the U.S. Bureau of Labor Statistics reported today. These improvements in the labor market reflected the continued resumption of economic activity that had been curtailed in March and April due to the coronavirus (COVID-19) pandemic and efforts to contain it. In June, employment in leisure and hospitality rose sharply. Notable job gains also occurred in retail trade, education and health services, other services, manufacturing, and professional and business services.

Unemployment Rate Seasonally Adjusted

The above Unemployment Rate Chart is from the BLS. Click on the link for an interactive chart.

Month-Over-Month Changes By Job Type

Hours and Wages

Average weekly hours of all private employees declined 0.1 hours to 34.5 hours. Average weekly hours of all private service-providing employees decline 0.1 hours to 33.5 hours. Average weekly hours of manufacturers rose 0.7 hours to at 39.7 hours.

Average Hourly Earnings of All Nonfarm Workers rose $0.07 to $29.39.

Year-over-year, wages rose from $28.05 to $29.39. That's a gain of 4.7%.

The month-to-month and especially year-over-year gains are very distorted because more higher-paid workers kept their jobs than lower-paid employees.

Average hourly earnings of Production and Supervisory Workers fell $0.11 to $24.63.

The decline is a good thing in that reflects more people returning to work.

Year-over-year, wages rose from $23.54 to $24.63. That's a gain of 4.6%.

For a discussion of income distribution, please see Whats Really Behind Gross Inequalities In Income Distribution?

Birth Death Model

Starting January 2014, I dropped the Birth/Death Model charts from this report.

For those who follow the numbers, I retain this caution: Do not subtract the reported Birth-Death number from the reported headline number. That approach is statistically invalid.

BLS Covid-19 Statement on the Birth-Death Model

The widespread disruption to labor markets due to the COVID-19 pandemic and the potential impact to the birth-death model have prompted BLS to both revisit research conducted in the aftermath of the Great Recession (2008-2009) and incorporate new ideas to account for changes in the number of business openings and closings. Two areas of research have been implemented to improve the accuracy of our birth-death model in the CES estimates. These adjustments will better reflect the net effect of the contribution of business births and deaths to the estimates. These two methodological changes are the following:

1: A portion of both reported zeros and returns from zero in the current month from the sample were used in estimation to better account for the fact that business births and deaths will not offset.

2: Current sample growth rates were included in the net birth-death forecasting model to better account for the changing relationships between business openings and closings.

BLS will determine on a monthly basis if the adjusted birth-death model described here continues to be necessary. We will disclose these changes each month in the Employment Situation news release. All months in the tables of net birth-death forecasts on this page include footnotes for any month in which a regressor was used to supplement the forecasts.

The Birth-Death model is essentially garbage but we likely will not find how distorted this is until the annual revisions next year.

Table 15 BLS Alternative Measures of Unemployment

Table A-15 is where one can find a better approximation of what the unemployment rate really is.

The official unemployment rate is 10.2%. However, if you start counting all the people who want a job but gave up, all the people with part-time jobs that want a full-time job, all the people who dropped off the unemployment rolls because their unemployment benefits ran out, etc., you get a closer picture of what the unemployment rate is. That number is in the last row labeled U-6.

U-6 is much higher at 16.5%. Both numbers would be way higher still, were it not for millions dropping out of the labor force over the past few years.

Some of those dropping out of the labor force retired because they wanted to retire. The rest is disability fraud, forced retirement, discouraged workers, and kids moving back home because they cannot find a job.

Strength is Relative

Its important to put the jobs numbers into proper perspective.

In the household survey, if you work as little as 1 hour a week, even selling trinkets on eBay, you are considered employed.

In the household survey, if you work three part-time jobs, 12 hours each, the BLS considers you a full-time employee.

In the payroll survey, three part-time jobs count as three jobs. The BLS attempts to factor this in, but they do not weed out duplicate Social Security numbers. The potential for double-counting jobs in the payroll survey is large.

Household Survey vs. Payroll Survey

The payroll survey (sometimes called the establishment survey) is the headline jobs number, generally released the first Friday of every month. It is based on employer reporting.

The household survey is a phone survey conducted by the BLS. It measures unemployment and many other factors.

If you work one hour, you are employed. If you dont have a job and fail to look for one, you are not considered unemployed, rather, you drop out of the labor force.

Looking for jobs on Monster does not count as looking for a job. You need an actual interview or send out a resume.

These distortions artificially lower the unemployment rate, artificially boost full-time employment, and artificially increase the payroll jobs report every month.

Seasonal Adjustments

The report this month is weaker than it looks. Huge seasonal adjustments were in play as were temporary Census jobs.

I discussed this yesterday evening in Seasonal Adjustments Likely to Boost Friday's Job Numbers

Recovery Will Take Years

Last month I notedThe Fed Promotes a Quickening that Takes Many Years

This report provides evidence. The recovery has slowed. Huge headwinds remain and the reopenings reversed in July.

The economy has added about 9.5 million jobs since the April lows.

However, jobs remain nearly 13 million jobs below the February 2020 peak. Millions of those jobs will not return.

Mish

More here:

The Jobs Recovery Is Not Yet Half-Way as Progress Slows - TheStreet

Kanye Shares Inspirations, Works in Progress and Unreleased YEEZY Footwear Designs – HYPEBEAST

Taking a break from his controversial political efforts, Kanye West recently took to Twitter to offer a look into his creative mind. Being heavily active on the social media platform over the last few months, Ye posted an array of images accompanied by brief musings that highlight the weight of each image.

Sharing, inspirations, works in progress and unreleased YEEZY footwear designs, Kanye revealed just how many elements of the culture he currently has his hands in. Standing out amongst the string of tweets are the looks at early YEEZY footwear designs include a top-down image of circles made up of unreleased colorways, a closer look at a yellow-focused adidas YEEZY BOOST 700 model, progressive slip-on models and what Ye claims is an upcoming Derrick Rose sneaker.

Aside from sharing inspirations from Herzog & de Meuron and James Turrell, Ye also offered a look at some of his progressive architecture designs. Building on the contemporary nature of his ideas, the creative looks to now be focusing on underwater homes with boulder doors inspired by Indiana Jones. Riddled throughout the stream of images are color studies that often deal with iridescent tones and weathered workwear.

Rounding up the Twitter spree is a look at a giant YEEZY model inflatable that is coming soon, a look at a Japanese mecha model, wholesome image of Kanye and his mother during their time in China and a notable jacket from Virgil Ablohs Louis Vuitton Spring/Summer 2021 collection.

Catch Kanye Wests latest Twitter spree below.

In case you missed it, ENG and Onelove look to bring archive fashion to China.

Go here to see the original:

Kanye Shares Inspirations, Works in Progress and Unreleased YEEZY Footwear Designs - HYPEBEAST

Pelosi Cites Progress on Stimulus With Two Sides Still Far Apart – Bloomberg

House Speaker Nancy Pelosi said negotiations on a new virus relief package are making progress, but the two sides remained at an impasse on major issues with their self-imposed Friday deadline for an agreement looming.

With no deal immediately in the offing, President Donald Trump said Thursday he is ready to sign orders extending enhanced unemployment benefits for the jobless and imposing a payroll tax holiday for employers and workers.

Pelosi and Senate Democratic leader Chuck Schumer are scheduled to meet again Thursday with Treasury Secretary Steven Mnuchin and White House Chief of Staff Mark Meadows for another round of negotiations to try to bridge the gap between them on the cost and breadth of another stimulus plan.

We have been making some progress, proceeding in a positive way, Pelosi said at a news conference. Were not there yet.

With progress slow, Senate Majority Leader Mitch McConnell on the Senate floor accused the two Democrats of stonewalling in the talks.

But Pelosi faulted McConnell for waiting until last week -- after earlier rescue measures expired -- to make a counteroffer to the $3.5 trillion stimulus plan that the House passed in May.

The fact is, when they showed up last week, it was already too late to prevent a lapse of extra unemployment insurance benefits, Pelosi said.

Staff members from each team were working on various proposals ahead of the negotiating session among the four principals scheduled for 5 p.m. in Washington.

Neither side indicated it would walk away if an agreement cant be reached by Friday. But Mnuchin and Meadows said that unless some compromise can be found soon, more talks may be fruitless.

Our objective is to try to reach an understanding of the major issues by Friday, Mnuchin told reporters after Wednesdays meeting with Pelosi and Schumer. If we cant reach an agreement on the major issues, its going to be hard to complete a deal.

Meadows said the two sides are still trillions of dollars apart on a compromise.

Meadows also said the administration and Republicans have already given more ground than Democrats in talks. He said the administration has been looking at legal issues with the president using his executive authority to take steps, that also include extending a moratorium on evictions and forbearance on student loans.

The administration is looking at the possibility of using money from the $2 trillion stimulus passed in March that hasnt been spent to extend the supplemental unemployment benefits, according to a person familiar with the matter. But there are are potential legal hurdles to redirecting the money.

I dont think they know what theyre talking about, Pelosi said about the White House redirecting money.

She said she supported the president extending the eviction moratorium, though more money will be needed to help those behind on rent catch up.

The talks take on added urgency as time passes. The November general election is 89 days away and economic data show signs that the economy is still hobbling along. The Labor Department reported that applications for unemployment benefits fell more than expected, to the lowest since the pandemic started. But with claims still exceeding 1 million on a weekly basis, the job market has a long road to fully recovering.

Senate Appropriations Committee Chairman Richard Shelby said negotiations were at an impasse right now.

Theres optimism and then theres pessimism, the Alabama Republican said. Sometimes theyre far apart and get close together on some things. We might not get a deal.

Meantime, McConnell is officially postponing the Senates scheduled August break, which was to begin on Friday. He said senators can return home, but will be called back if theres a vote on a relief bill. The House is on break, but lawmakers there have been told they could be recalled to Washington on 24 hours notice.

With assistance by Steven T. Dennis, Saleha Mohsin, and Skylar Woodhouse

(Updates with Trump preparing orders on stimulus in second paragraph)

Before it's here, it's on the Bloomberg Terminal.

Continue reading here:

Pelosi Cites Progress on Stimulus With Two Sides Still Far Apart - Bloomberg

COVID-19 in Africa: Dampening the storm? – Science

Coronavirus disease 2019 (COVID-19) has spread rapidly and extensively to most countries in the world, resulting in considerable mortality in Europe and the United States, as well as in numerous upper-middle-income countries in South America and Asia. Experts predicted millions of COVID-19 deaths in Africa because many countries in the continent rank poorly on the United Nations Development Programme's Human Development Index. However, more than 4 months after the first cases in Africa were detected, prevalence and mortality are still low. It remains unclear if Africa is really spared from substantial cases and deaths. However, differences between Africa and the most affected countries in reliable reporting and death registration, lockdown stringency, demography, sociocultural aspects, environmental exposures, genetics, and the immune system could help to explain the experience of COVID-19 in Africa.

Africa faces major health and socioeconomic challenges that should have allowed rapid transmission of COVID-19. These include a weak health system (per capita health expenditure of <$50 in most West African countries compared with >$2500 in Europe and the United States), population crowding, poverty, and unhygienic conditions (1). Population densities are very high in most African capital cities such as Dakar (12,617 persons/km2), Abidjan (11,155 persons/km2), or Lagos (13,909 persons/km2), whereas New York City has 7101 persons/km2. However, although community transmission was reported in many major African cities months ago, the predicted number of cases and deaths has not yet been observed (see the figure). Low case numbers are often attributed to insufficient testing. However, many African countries implemented testing early on, and, based on the Our World in Data database (2), more tests per the number of cases were carried out than in other countries at similar phases of the epidemic (see the figure). Regarding the number of deaths, few functional civil registration services and thus statistics exist on the continent, raising questions about the reliability of mortality data. Potential underreporting of COVID-19associated deaths would not be specific to Africa, but the margin of error could be wider. To date, African countries have not indicated acute health emergencies; however, reliable age-stratified data are needed to fully grasp the COVID-19 situation in Africa to allow appropriate measures to be taken.

Measures such as travel restrictions, curfews, and school closures were implemented early in Africa compared with other continents, often before an African country had detected a case (fig. S1). These early responses might have resulted in fewer imported cases and reduced intracountry transmission, allowing sufficient time to prepare the constrained health systems for diagnosis and to prepare strategies for quarantine, contact tracing, and social distancing on a continent that already has experience in such practices to control epidemics such as Lassa fever and Ebola. Although it is likely that the early lockdown in Africa contributed to the slow spread, containment measures are not fully respected in many countries. Most people work in the informal business sector, such as in traditional markets, making strict lockdown measures impossible to implement. Recently, some African governments have been pressured to relax lockdown measures, for example, to carry out congregational prayers in mosques in Senegal. It remains unknown whether relaxation of containment measures will result in increased cases or if other factors are at play.

The majority of COVID-19associated deaths occur in older people. Africa has a comparatively young population, with a median population age of 19.7 years for the continent versus 38.6 years for the United States. Africa's youthful population is reflected in the structure of age-stratified cases (fig. S2). Based on global age-specific case fatality rates for COVID-19 and the age demographics of Africa, COVID-19 deaths would be expected to be only four times (3), rather than the observed 40 times, lower than in Europe or the United States. However, no aggregated data on age-specific case or death rates are available for the continent. There is substantial intergenerational mixing in Africa, and, with more cases of subclinical infections in the young, it could be a matter of time before expansive numbers of cases and deaths are recorded. Alternatively, a more rapid development of herd immunity among the youthful population might lead to fewer severe cases. Data from antibody tests (serosurveys) should clarify if transmission was more widespread with a high rate of asymptomatic and mild cases in African countries than in other countries.

The genetic characteristics of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human genetics may be among the reasons for low incidence of severe COVID-19 in Africa. Although the relative contribution from Africa to the SARS-CoV-2 GISAID (Global Initiative on Sharing All Influenza Data) sequence database is small, the isolates found in Africa are representative of the different clades of SARS-CoV-2 found on other continents (fig. S3). Thus, it is unlikely that strains of SARS-CoV-2 in Africa have reduced virulence. Moreover, African-Americans constitute a disproportionate burden of deaths in the United States, so it seems unlikely that the lower mortality from COVID-19 in Africa is due to genetic factors. Nonetheless, the COVID Human Genetic Effort consortium aims to elucidate whether genetics can play a role in the patterns of disease worldwide.

SARS-CoV-2 infection leads to a heterogeneous outcome. About 80% of symptomatic cases are mild to moderate, whereas 20% can develop severe respiratory disease and display high rates of mortality (4). The development of an effective adaptive immune response can limit viral infection, whereas uncontrolled activation of innate immune cells leads to a cytokine storm and hyperinflammation in the lungs, ultimately leading to acute respiratory distress syndrome (ARDS) and multiorgan failure (4, 5). Being able to suppress viral infection early or to temper excessive inflammatory responses are likely complementary mechanisms to prevent severe disease.

Most convalescent symptomatic COVID-19 patients develop virus-specific neutralizing antibodies as well as specific CD4+ and CD8+ T cell responses (5). The efficiency and adequacy of these adaptive responses to clear viral infections depends on multiple factors, including past or concurrent infections with other pathogens. For example, antibodies directed to the four human coronaviruses that cause common colds could cross-react and neutralize SARS-CoV-2 in humans (6), and preexisting cross-reactive T cells can be found in individuals that have not been exposed to SARS-CoV-2 (7), suggesting previous exposure to related human coronaviruses could generate immunological cross-reactivity (7).

There are considerable differences in environmental exposures in Africa, compared with Europe or the United States. Noncommunicable diseases (NCDs)such as cardiovascular diseases, obesity, and type 2 diabetesare risk factors for severe COVID-19. These environmentally and behaviorally driven conditions are increasingly recognized in urban centers in Africa, and most COVID-19 deaths in Africa have been in older people with NCDs. However, infectious diseases such as HIV, tuberculosis, malaria, and other respiratory infections or those caused by helminths (parasitic worms) are prevalent in Africa, but there is currently little information on whether, or how, these infections affect COVID-19 disease progression.

The distribution of coronavirus disease 2019 (COVID-19) cases and deaths per 1 million inhabitants per continent reveals surprisingly low rates in Africa (left). This is despite comparable levels of testing per confirmed cases across continents (right). The dotted lines show the number of tests performed per number of detected cases. Data are from European Centre for Disease Prevention and Control COVID-19 situation updates, United Nations World Population Prospects 2019, and Our World in Data (2).

It is increasingly recognized that the immune system is shaped not only by genetics but also by environmental factors, such as exposure to microorganisms and parasites. This educates the immune system to protect against invading pathogens not only specifically but also nonspecifically through, for example, trained immunity, which involves the reprogramming of innate cells that, on secondary encounter with a pathogen, can show a stronger response (8) or virtual memory (9). Virtual memory T cells (TVM cells) expand in response to cytokines such as helminth-induced interleukin-4 (IL-4), rather than through pathogen-specific antigens, leading to enhanced antiviral effector functions (9). Thus, it can be envisaged that TVM cells are more prevalent in people in Africa owing to the higher exposure to such pathogens. This could contribute to the control of SARS-CoV-2. Additionally, as postulated by the hygiene hypothesis, early and chronic exposure to pathogens leading to relentless immune cell activation in harsh environments induces a strong regulatory immune response to counteract excessive inflammation (10).

The ability to prevent excessive inflammation could be a critical parameter that is associated with COVID-19 outcome. Recent data suggest that inflammatory alveolar macrophages (AMs), which can arise from differentiation of recruited monocytes upon infection, are increased in the lungs of patients with severe COVID-19 (11). It is unclear whether these monocyte-derived AMs are an important source of the cytokine-release syndrome observed during SARS-CoV-2 infection or whether they are involved in the pathogenesis of ARDS. However, monocyte and macrophage inflammatory cytokines, such as IL-6, have been repeatedly observed to be a marker of severe COVID-19, and myeloid cells are thus likely to be associated with the hyperinflammation. Monocytes from African individuals with high exposure to pathogens can be less proinflammatory (12). Thus, their recruitment into the lungs might prevent high cytokine production and therefore lead to better outcomes of COVID-19. Moreover, the airway microbiota, as well as more distal gut microbiota, could play important roles in preventing or potentiating respiratory tract infections and modulating virus-induced inflammation, as has been shown for several respiratory viruses (13). The known variations in microbiota across geographical areas could thus also participate in modulating disease severity and should be studied.

Africa should be part of the roadmap for COVID-19 research. Although there are no available data on the immune responses in African COVID-19 patients, studies show clear differences in the activation, proinflammatory, and memory profiles of the immune cells not only in Africans versus Europeans but also among Africans with high and low exposure to microorganisms and parasites (14) (fig. S4). Does the difference in immunological profiles matter for the outcome of COVID-19 in Africa? This needs further investigation, and the pattern of COVID-19 in urban and rural Africa could be informative.

There are differences in opinion about whether the pattern of SARS-CoV-2 spread is different in Africa compared with that in the United States and Europe. So far, despite a paucity of data, it appears that the virus is spreading differently and potentially with an attenuated outcome in Africa. There has been limited testing of asymptomatic cases or of antibody titers. Therefore, it is unknown whether early interventions were successful in preventing transmission or whether there are differences in susceptibility between populations of different regions. Perhaps the COVID-19 pandemic can emphasize the need for widespread implementation of public health tools, such as high-quality data, accurate diagnostics for track and trace, good communication, and an effective vaccine. Early testing of vaccines in different regions of Africa is essential because the high degree of exposure to pathogens can limit some vaccine responses (15). The first COVID-19 vaccine testing is starting in South Africa (Ox1Cov-19 Vaccine VIDA-Trial), and others are planned. Hopefully, this will stimulate the full participation of Africa in research into the critical factors that hold the key to innovative solutions in the fight against the pandemic.

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COVID-19 in Africa: Dampening the storm? - Science

Pacific Biosciences and Asuragen Collaborate to Develop Assays for Carrier Screening and other Applications Based on SMRT Sequencing Technology and…

AUSTIN, Texas & MENLO PARK, Calif.--(BUSINESS WIRE)--Pacific Biosciences of California, Inc. (Nasdaq:PACB), a leading provider of high-quality sequencing of genomes, transcriptomes and epigenomes, and Asuragen, a molecular diagnostics company delivering easy-to-use products for complex testing in genetics and oncology, today announced their clinical research collaboration aimed at developing molecular assays based on PacBios Single Molecule, Real-Time (SMRT) Sequencing technology. The initial focus of the collaboration will be on research in support of assay development for the carrier screening market.

Several of the most common carrier genes for autosomal recessive and X-linked conditions are either technically challenging or inaccessible to amplify and sequence, leading to incomplete coverage and convoluted workflows spread over multiple platforms. Through this collaboration, Asuragen scientists will develop assays that combine the companys AmplideX PCR technology for enriching hard-to-amplify sequences with PacBio SMRT Sequencing, a highly accurate long-read sequencing platform with a unique ability to represent all regions of the genome and to detect any kind of structural or other variation.

Innovative amplification and sequencing technologies have each been instrumental in discovering and characterizing challenging disease-causing structural variants, such as indels, copy number changes, and repeat expansions, said Gary J. Latham, PhD, Senior Vice President of Research and Development at Asuragen. We are excited to work with PacBio to combine the best of both technologies to build assays that can uniformly resolve simple and complex forms of genetic variation for research and clinical applications.

Scientists at Asuragen will develop assays for PacBios Sequel Systems using Asuragens AmplideX PCR technology. AmplideX products are designed to solve testing needs in inherited genetic disorders through easy-to-run assays and optimized workflows that deliver best-in-class performance. Assays will make use of PacBios HiFi long reads, an approach incorporating multiple passes of the same molecule to create a highly accurate consensus sequence.

We are honored to partner with Asuragen, a leader in molecular diagnostics, to apply the unique value of SMRT Sequencing for clinical research, said Jonas Korlach, PhD, Chief Scientific Officer of Pacific Biosciences. Scientists have shown that PacBios long-read sequencing systems offer a high-resolution view of the human genome that is simply not possible with any other sequencing technology. We look forward to working with Asuragen to design assays capable of interrogating challenging genomic regions and identifying the full breadth of natural human genetic variation.

About Asuragen

Asuragen is a molecular diagnostic product company changing the way patients are treated in genetics and oncology. Asuragens diagnostic systems, composed of proprietary chemistry and software, deliver powerful answers using broadly installed instrument platforms. They are simple to adopt and expand the ability to serve patients. Asuragen is a product foundry rapidly and efficiently addressing current and emerging clinical needs, including cancer diagnosis and monitoring, reproductive health and aging, serving laboratories across a patients lifespan with its best in class diagnostic tests. For more information, visit http://www.asuragen.com.

About Pacific Biosciences

Pacific Biosciences of California, Inc. (NASDAQ:PACB), is empowering life scientists with highly accurate long-read sequencing. The companys innovative instruments are based on Single Molecule, Real-Time (SMRT) Sequencing technology, which delivers a comprehensive view of genomes, transcriptomes, and epigenomes, enabling access to the full spectrum of genetic variation in any organism. Cited in thousands of peer-reviewed publications, PacBio sequencing systems are in use by scientists around the world to drive discovery in human biomedical research, plant and animal sciences, and microbiology. For Research Use Only. Not for use in diagnostic procedures. For more information please visit http://www.pacb.com and follow @PacBio.

Forward-Looking Statements

All statements in this press release that are not historical are forward-looking statements, including, among other things, statements relating to market leadership, uses, accuracy, quality or performance of, or benefits of using, our products or technologies, including SMRT technology, the suitability or utility of our methods, products or technologies for particular applications or projects, the expected benefits of the research collaboration with Asuragen, the ability of the Company to be successful in reaching its technological and commercial potential, and other future events. You should not place undue reliance on forward-looking statements because they involve known and unknown risks, uncertainties, changes in circumstances and other factors that are, in some cases, beyond Pacific Biosciences control and could cause actual results to differ materially from the information expressed or implied by forward-looking statements made in this press release. Factors that could materially affect actual results can be found in Pacific Biosciences most recent filings with the Securities and Exchange Commission, including Pacific Biosciences most recent reports on Forms 8-K, 10-K and 10-Q, and include those listed under the caption Risk Factors. Pacific Biosciences undertakes no obligation to revise or update information in this press release to reflect events or circumstances in the future, even if new information becomes available.

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Pacific Biosciences and Asuragen Collaborate to Develop Assays for Carrier Screening and other Applications Based on SMRT Sequencing Technology and...

Kazia Therapeutics hits A$1 on grant of Rare Pediatric Disease Designation to paxalisib for DIPG – Proactive Investors USA & Canada

The US FDA has awarded RPDD to paxalisib for the treatment of Diffuse Intrinsic Pontine Glioma, a rare and highly aggressive childhood brain cancer.

() () has surged on being granted Rare Pediatric Disease Designation (RPDD) by the US FDA for its paxalisib for the treatment of DIPG, a rare and highly aggressive childhood brain cancer.

With RPDD granted, Kazia may now be eligible to receive a rare pediatric disease priority review voucher (PRV) if paxalisib is approved for Diffuse Intrinsic Pontine Glioma (DIPG).

A PRV grants the holder an expedited six-month review of a new drug application by FDA.

PRVs can be sold to other companies and have historically commanded prices between US$68 million and US$350 million.

Shares have been more than 78% higher in early trade to a new 3.5 year high of A$1.00.

Kazia CEO Dr James Garner said: Although glioblastoma remains our primary focus for paxalisib, we have been devoting increasing energy to developing the drug in childhood brain cancer as well.

"For patients diagnosed with DIPG, there are currently no FDA-approved drug treatments, and the average survival from diagnosis is around 9.5 months.

Garner said: "The granting of RPDD by the FDA recognises our efforts and achievements so far and leaves us well placed to move paxalisib forward as a potential therapy for DIPG.

"We continue to be inspired by the dedication of our collaborators in this field and are committed to understanding whether paxalisib may be able to help in this enormously challenging paediatric disease.

RPDD has been awarded following positive emerging preclinical data in DIPG and with initial clinical efficacy data expected in the current half-year, positive clinical data may substantially enhance the likelihood of a potential future PRV.

The US Food and Drug Administrations (FDA) RPDD program is intended to advance the development of drugs and biologics for certain serious and life-threatening rare pediatric diseases by providing incentives to industry.

Most significant among these incentives is the potential access of a priority review voucher at the time of a marketing authorisation for the rare pediatric disease.

RPDD may be granted to drugs in development for diseases which primarily affect children under the age of 18, have an incidence of less than 200,000 new cases per annum in the US and which are serious or life-threatening.

In October 2018, St Jude Childrens Research Hospital in Memphis, Tennessee, began a phase I clinical trial of paxalisib in DIPG (NCT03696355).

This study reported favourable top-line safety data in September 2019 and established 27 mg/m2 as the maximum tolerated dose for paediatric use.

The study has completed recruitment and initial efficacy data is anticipated during the second half of 2020.

This data will be used to guide future development of paxalisib (formerly GDC-0084) in this disease.

Dr Matt Dun and colleagues at the University of Newcastle, Australia have conducted extensive laboratory research with paxalisib, focused on phosphoproteomic analysis of its activity in DIPG cell lines.

Phosphoproteomics is a new approach in cancer research that attempts to discern how complex signalling pathways are modified in tumours.

Work at the Dun laboratory has shown paxalisib to be broadly active in DIPG and has identified a number of potential combination strategies which may enhance its activity.

Initial data was presented at the Society for Neuro-Oncology (SNO) Pediatric Neuro-Oncology Basic and Translational Research Conference in San Francisco, CA, in May 2019.

Further ongoing work in animal models is expected to provide additional insight.

In parallel, related laboratory research is underway in the DMG Research Center at the University of Zurich, Switzerland, under the leadership of Dr Javad Nazarian.

Dr Nazarian is also the principal investigator at Center for Genetic Medicine within the Childrens National Medical Center, Washington DC with a focus on DIPG.

Laboratory research is also being conducted at St Jude Childrens Research Hospital by Dr Chris Tinkle and Dr Suzanne Baker and colleagues, in parallel to the ongoing phase I clinical trial at that centre.

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Kazia Therapeutics hits A$1 on grant of Rare Pediatric Disease Designation to paxalisib for DIPG - Proactive Investors USA & Canada

Treatment Considerations for Prostate Cancer Progressing After Combination Therapy for mCSPC – UroToday

(UroToday.com) In conjunction with the Scientific Congress held as part of the American Society of Clinical Oncologys (ASCO) Annual Meeting in May 2020, an Educational Symposium was convened on August 8 to 10th. In a session entitled Sorting Through the Maze of Treatment Options for Metastatic Castration-Sensitive Prostate Cancer, Dr. Alicia Morgans from Northwestern University presented a plenary talk discussing the treatment considerations for patients who received combination therapy for metastatic castration sensitive prostate cancer (mCSPC). This followed prior presentations from Dr. Carmel Pezaro and Dr. Neal Shore regarding the role of chemotherapy and novel androgen axis inhibitors in patients with mCSPC.

Dr. Morgans began by highlighting that, as per National Comprehensive Cancer Network (NCCN) guidelines, combination therapy with androgen deprivation therapy and another agent (apalutamide, abiraterone, docetaxel, or enzalutamide) is recommended.

While there are a number of treatment options for patients with mCSPC, there is an even greater plethora of treatment options for patients with metastatic castration-resistant prostate cancer (mCRPC), with no less than seven different agents available on the basis of prior therapies received, patient characteristics, and tumor characteristics.

Clearly, prior lines of therapy (including those used in the mCSPC space) influence future treatment choices when the patient progresses to mCRPC. In the mCRPC disease space, treatment choices may be guided by the following factors, among others:

1. prior treatment received, with a preference for novel mechanisms of action2. treatment availability in practice setting/location3. presence of visceral metastasis or restriction to bone-only metastasis4. candidacy for chemotherapy, on the basis of patient comorbidity and frailty5. histologic characteristics, including the presence of small cell/neuroendocrine differentiation6. targetable genetic or genomic characteristics including actionable DNA damage repair mutations or presence of microsatellite instability high status7. availability of clinical trials

Dr. Morgans highlighted that resistance mechanisms can spread through metastasis-to-metastasis seeding and similar resistance patterns are often seen in geographic proximity suggesting an element of interclonal cooperativity. As a result, at the time of disease progression, the use of therapy with a novel treatment mechanism is necessary to counter to acquired resistance.

As a general principle, Dr. Morgans outlined that sequencing of androgen axis inhibitors (including abiraterone acetate, enzalutamide, apalutamide, and darolutamide) is generally poorly effective. To drive home this point, Dr. Morgans reviewed data from the CARD trial which randomized patients who had progression on one androgen axis targeting agent to a switch or to cabazitaxel. Only 14% of patients who switched to the other androgen axis targeting agent had a PSA response of 50% or more and median progression-free survival was only 2.7 months (95% confidence interval 2.4 to 2.8 months) in contrast to median progression-free survival of 4.4 months (95% confidence interval 3.6 to 5.4 months) among those randomized to cabazitaxel (hazard ratio 0.52, 95% confidence interval 0.40 to 0.68). Similarly, in PROfound, patients who had disease progression on a novel androgen axis inhibitor were randomized to physicians choice of therapy (often including a switch to another androgen axis inhibitor) or Olaparib. As with the CARD trial, patients randomized to a second androgen axis inhibitor had median progression-free survival of 3.55 months (hazard ratio 0.34, 95% confidence interval 0.25 to 0.47).

Apart from these randomized data, there are a number of other studies that have assessed response rates for sequencing of androgen axis targeting agents demonstrates generally short progression-free survival.

Dr. Morgans then highlighted data that may guide specific treatment considerations in particular populations. First, she reviewed data from the PROCEED observational registry of patients treated with sipuleucel-T. In a prostate-specific antigen (PSA) matched analysis, median overall survival was significantly longer for African American men (35.3 months) as compared to Caucasian men (25.8 months) (hazard ratio 0.70, 95% confidence interval 0.57 to 0.86). Further, baseline PSA at the time of initiating sipuleucel-T therapy was associated with survival patients with PSA below the median (29.5 ng/mL) had improved survival (hazard ratio 0.52, 95% confidence interval 0.37 to 0.72).

In an international early access program, observational data suggested that asymptomatic patients receiving radium-223 had significantly improved overall survival compared to those who were symptomatic at the initiation of therapy (hazard ratio 0.49, 95% confidence interval 0.33 to 0.73).

Beyond clinicodemographic factors, Dr. Morgans discussed genetic and genomically targeted approaches. She first examined data from TRITON2 in which patients with mCRPC and deleterious mutations in DNA defect repair (DDR) genes who had progressed on androgen axis targeting agents received rucaparib in a single-arm design. The vast preponderance of patients had a beneficial PSA response. Subsequently, the PROfound study reported a randomized comparison of Olaparib versus physicians choice among a similar patient population. They demonstrated significantly improved radiographic progression-free survival among those receiving olaparib (median 5.8 months) versus physicians choice of therapy (median 3.5 months; hazard ratio 0.49, 95% confidence interval 0.38 to 0.63). Great detail regarding the data for PARP inhibitors in prostate cancer is provided in a UroToday Center of Excellence article.

On the basis of these data, rucaparib has been approved for men with BRCA1/2 mutations who have progressed following androgen receptor-targeted therapy and taxane chemotherapy while olaparib has been approved for men with Homologous Recombination Repair (HRR) mutations following androgen receptor-targeted therapy, with or without prior taxane treatment.

Beyondpoly ADP ribose polymerase (PARP) inhibitors, pembrolizumab is another targeted option for men with advanced prostate cancer. In this case, patients must have microsatellite instability-high status to be eligible, as the United States Federal Drug Administration (FDA) has approved pembrolizumab in a tissue agnostic fashion for patients with microsatellite instability-high tumors. Dr. Morgans reported that approximately 2-3% of men with prostate cancer will have microsatellite instability-high tumors, and are therefore expected to have radiographic responses to pembrolizumab.

Dr. Morgans closed by highlighting the importance of shared decision making for patients with advanced prostate cancer. This is particularly important where there are so many treatment options. Patient preferences may be driven by home or work obligations, by past or vicarious experiences or fears, by insurance restrictions, and other factors.

Moving forward, Dr. Morgans highlighted the potential for theranostics, including the therapeutic role of Lutetium-177-prostate-specific membrane antigen (LuPSMA). A number of ongoing trials will assess the role of Lu-PSMA, including in a comparison against cabazitaxel in patients who have progressed following docetaxel and in comparison against best supportive or standard of care in patients who have progressed following both taxane chemotherapy and an androgen axis inhibitor.

Presented by: Alicia Morgans, MD, MPH, Associate Professor of Medicine in the Division of Hematology/Oncology at the Northwestern University Feinberg School of Medicine in Chicago, Illinois

Written by:Christopher J.D. Wallis, Urologic Oncology Fellow, Vanderbilt University Medical Center,@WallisCJD on Twitteratthe ASCO20 Virtual Education Program, #ASCO20, August 8-10, 2020.

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Treatment Considerations for Prostate Cancer Progressing After Combination Therapy for mCSPC - UroToday