The Covid-19 Effect: Conversation Territories In The New Normal – PRovoke Media

INTRODUCTION

Humanity may indeed have developed some formidable technologies for accumulating information, but the truth is, our memories remain very short. It has only taken two or three generations to forget about the consequences of the poorly named Spanish flu that killed hundreds of millions around the world between 1918 and 1919. Tragic loss of life aside, that pandemic went on to revolutionize many aspects of society, culture and the economy by introducing structural changes in the ways people lived. We need look no further than Spain to see that it accelerated the role of industry, thus raising the country out of a farming economy; forced a transformation of waste management systems, which did not exist as they do today; and changed the way cities were designed, introducing large plazas to avoid crowds. Some studies even suggest that the pandemic had a decisive impact on World War I. With death and disease among hundreds of thousands of soldiers accelerating an end to the fighting and forcing a bad peace treaty (Versailles), which simply led to a second World War 20 years later.

We forget that, 100 years ago, a virus came and changed almost everything. History is repeating itself now, and a new virus has arrived in 2020 to shake up a society that we already thought was moving fast. Or so we believed, from atop our tower of stability. A fluid society and constant uncertainty loom over the horizon, and our ingenuity is only now being revealed.

With a hard lesson in humility under our belts, this report tries to highlight the big conversations we are seeing take shape. Some are mutating into something else, and several more we strongly doubt will remain as they are today. All of these conversations are and will be undoubtedly digital, because that is an inherent condition of conversation itself in todays world.

Seeing the bigger picture may help readers navigate the rough seas of decision-making that surround the issues impacting business: Where might regulatory decisions take us? What are my consumers concerned about? And what issues should I focus on in my relationships with my stakeholders? Nobody has all the answers, but we may be able to find a few of them together if we start here.

Maria Branyas is the oldest person in Spain. She is 113 years old. She lives in Olot (Girona, Spain), and she has just recovered from the coronavirus. She was born in 1907, so she also lived through the Spanish flu as well. She recently said, From the solitude of my room, fearless and with hope, I dont really understand what is happening in the world. But I dont think anything will be the same again. And dont think about redoing, recovering or rebuilding. Everything will need to be done again, and done differently.

Everything will need to be done again. We should listen to our elders.

To develop this report, we conducted 62 vertical analyses of territories and communities on Twitter (a total of over 180 million tweets), and we monitored trends over time in search frequency for keywords and key issues on Google regarding the territories of interest.

1. GLOBALIZATION VS. LOCALISM

The breakdown of globalization as we have known it for the last few decades has been in the cards since the 2008 financial crisis. Perhaps the coronavirus pandemic is the killing blow. International trades expansion era had been dwindling since the beginning of the trade war between the United States and China, initiated by tariff impositions and departures from international agreements. Now, supranational organizations have been unable to show usefulness in building a coordinated solution to the pandemic, which will leave serious wounds on multilateralism and international cooperation. This will be further exacerbated by national protectionist ideologies.

The following months may put into question the ways major corporations function, as well as their very natures. The pandemic has lent support to the protectionist and nationalist arguments (albeit for different reasons) of certain political leaders, such as Trump and Bolsonaro, by firmly committing to industrial sovereignty over production and value chains. Whereas Twitter conversations in this territory in April 2019 were full of hashtags about Brexit and Trumps nationalist posturing, COVID-19 and references to the supply chain are gaining popularity in the same period in 2020. These are interspersed with political slogans, and a more complex and argued conversation is being constructed.

The pandemic has driven conversations about company value chains toward a focus on greater resilience based on supplier diversification, as well as greater digitalization. This will enable them to deal with future disruptions. Beyond the structural effect on supply chains, however, the COVID-19 effect has another short- and medium-term impact: International tourism. It may be safe to assume that the mobility restrictions will be temporary, but we are facing a period in which action protocols and fear of contagion will be the main barriers to overcome: bureaucracy, social distancing, order, waiting, processes The free will normally associated with tourism will continue to be constrained. In this reconfiguration, the most-developed countries could have an advantage in terms of demand when compared to exotic destinations, as healthcare systems are often less advanced in this locations, affecting travelers perceptions of safety when they choose to go on holiday.

While the COVID-19 effect enables a reduction in the trade of physical goods and individual mobility, digital globalization might well gain popularity. Online relationships and services have demonstrated strength during this crisis, with teleworking at the top of the list. Nonetheless, this will be accompanied by the first major consequence: A reemergence of localism in an inverse process of globalization. The bureaucratic burdens on the exchange of goods and people are leading to attention and concern for what we have close by, including our neighbors, local produce and news from our own neighborhoods. All things nearby have proven useful and tangible during this crisis, which has contributed to a reassessment of the local social fabric. Neighborhoods are now leading the new scale of how service integration and emotional connections are measured.

2. THE WELLBEING REFORM

This pandemic has profoundly rearranged Maslows hierarchy of human needs, built after the end of World War II. We are returning to needs we thought long since overcome, such as the need for physical safety and health, which are perhaps even more basic than the need to breathe after all, we are sometimes scared to breathe in certain places. Therefore, the post-COVID concept of wellbeing has been widened at the base, and these needs rise to the same level as personal care, aesthetics and nutrition. We can see it in the figures: Conversations about beauty have fallen by 62 percent when compared to last year;those about nutrition are down by 70 percentand those on wellbeing by 37 percent

Furthermore, one subject that had been sidelined from the public agenda for too long has returned with force, and it is considered by many studies to be the next major challenge in healthcare management: The populations mental health in a post-traumatic situation.

Three important conversations on the topic of wellbeing are highlighted below:

3. SENIORS AND THE IMPORTANCE OF CARE

It reads like a fiction story. Two months ago, we thought of the Baby Boomers (active people over 60 with savings for whom their age was not an issue) as a driving force behind the economy due to their investment in leisure and wellbeing, especially now that life expectancy is longer. However, theres nothing better than a dose of reality to put us in our place and force us to see the other side of the debate around seniors: Care.

Whether paid or not, care will be a major social issue in the years ahead. The crisis, combined with the 18,000 elderly people who have died in care homes and this populations extreme vulnerability to the virus, has proven how important an integrated care policy could be. The care economy accounts for 15 percent of Spains GDP. According to the Care Work and Care Jobs for the Future of Decent Work report by the ILO, changes to family structures, higher care dependency ratios and changing care needs, combined with an increase in the level of womens employment in certain countries, have eroded the availability of unpaid care work and resulted in an increase in the demand for paid care work.

Looking at the figures, the care world may simply be seen as another area undergoing a transition process, moving from unpaid work by family members to paid work from outsourcing this care, and that the three pitfalls, two pending reforms and change of mentality listed below must be addressed.

The three pitfalls we may encounter are:

The two pending reforms are:

Organizations will be forced to reconsider their roles, with a focus on not only the adaptation of assets and services, but also on social contribution, including the importance of care and how we interact with one another in our most immediate environments. Consumers are looking to find a framework brand values that forms an active part of the solution. Usefulness, generosity, commitment and the need to help one another is the new language for companies seeking to connect with people.

4. CRACKS IN EDUCATION

Education is another area that has been thrown up in the air by COVID-19. Nothing about this situation is new, but what feels like five years have passed in a matter of weeks. We will be talking about education a lot, and we will be talking about an education system that is expected to produce resilient and employable citizens. Resilience is the new humanism in an education sector fighting for the competitiveness of its offering while trying to manage five deep cracks.

Breaking away from physical spaces

In this COVID-19 crisis, 91 percent of pupils around the world (equal to 1.5 billion children and young people) have been forced to start learning from home. Technology has proven to be an essential ally in keeping up with classes, leading to an access gap of around 10 percent in compulsory education and 3 percent in university education in Spain alone. Blended face-to-face and online learning has received the backing it needed over the last few weeks, and everything suggests that the 2020-2021 school year will be its debut year, although regional government authorities, schools and parents are showing reticence toward a model that has not yet been proven to work.

Breaking away from the figure of teacher

Educators have been going through a process of trial and error for years. Conventional classrooms dont work, and neither does conventional teaching. Memorization has been left behind, and gamification and shared knowledge have taken its place. From the all-knowing teacher, we have shifted to answers being available everywhere at the click of a mouse. Students no longer needed teachers to acquire knowledge. Even so, teacher figures are more important than ever. Therein lies the challenge.

Breaking away from knowledge

This is all because education is also now a combination of skills and abilities. Knowledge, as static and linear boxes, has no value in a world that is constantly on the move and transforming. Functional, emotional and resilient citizens capable of understanding the complexity of its contradictions; of developing technical, applicable responses; of exercising emotional intelligence both on their own and with others; of being creative and collaborative are the new Michelangelos of this world. Now that we are physically distancing ourselves from one another, it is more important than ever to build a community.

Breaking away from qualifications

Education used to be a continuous line, accumulative and limited by time. The concept of lifelong learning emerged as a figure of speech, but it eventually took hold to become reality in most productive sectors. Long and linear academic careers will not be competitive. Rather, pill-based learning with practical seminars, anti-master classes and short bursts will be what improves our functionality, capable of fitting into our professional and family lives while limiting the onset of obsolescence. This has led to the success of MOOCs (Massive Open Online Courses) and progress towards a singularization of education.

Breaking away from the promise of equality

Education will be experience-based, achieved through the use of artificial intelligence and virtual reality. This wont happen immediately and will take place at different speeds, leading to numerous debates around equal opportunity (perhaps the most relevant topic in the field of education) and the supposed unfair competition from new players in the sector (mainly technology and entertainment operators and platforms). The problem lies in the widening gap between economic classes and the disincentive the most vulnerable parts of society will feel toward education, with a growing trend of leaving school early. This will be seen in the dichotomy between public and private, between science and the arts, between central and peripheral. Each one of these cracks is opening an equal opportunities gap that can only be faced through state policy that understands education as a lever for national competitiveness.

5. THE DEFINITIVE REINVENTION OF ENTERTAINMENT

This crisis has poured more fuel onto the fire in the entertainment industry, accentuating the problems and opportunities stemming from digitalization and the democratization of production and access to content. The conflict between digitalization and face-to-face experiences has heightened existing tensions between traditional industry models (based on controlling content licenses and their broadcast times) and new methods of consuming media. In the audiovisual industry, those who will suffer the biggest loses from COVID-19s impact will be the cinema screening chains, which have been fighting against new over-the-top (OTT) players, such as Hulu, Netflix or Amazon Prime Video, over screening windows for the past several years. Movie theaters now see their business being damaged not only by audience perceptions of insecurity, but also by the consolidation of on-demand consumption in peoples homes. Most of the big players in production and distribution have sufficient streaming windows to make their products available to audiences, even during a pandemic situation like this. This situation is forcing the traditional screening industry to reinvent itself or possibly even ally with its competitors. This has been furthered by major events and awards, such as Cannes or the Oscars, which are starting to open their doors to new formats in their selection and screening criteria.

The problem is multiplied in the music world, which was already being dragged down by far more serious endemic problems. The industry already struggles with being unable to find a sustainable model that would allow them to survive while also responding to the realities of modern consumers. Until now, the streaming model sought to replace the traditional one, ruled by record labels that mixed artist management with a focus on live performances. Artists tend not to support switching to selling licenses to streaming services due to how little they are paid for it. However, while the rate of audiovisual content consumption on streaming platforms has continued to climb during the lockdown, the consumption of music on players such as Spotify or Deezer has fallen. This is coupled with disaster in the live performance industry, which will take far longer to recover given the difficulty of safely running concerts or festivals like the ones weve enjoyed up to now. The music industry, which was still trying to adjust to the digital age in 2020, will need to completely reinvent itself due to the effects of COVID-19.

In turn, gaming (which the cinema and TV series industries see as the main competitor for consumer attention) is coming out on top during the pandemic. However, that triumph is being offset by the growing e-sports industrys excessive dependence on large-scale events, which had previously been the main focus for brand investment. The vacuum created without these events is an opportunity for publishers and broadcast and conversation platforms such as Twitch, which brands had not utilized until now.

This pandemic leaves us with an entertainment industry that will need to accelerate its digital transformation and overcome its excessive dependence on face-to-face experiences. They will be competing with the rising production and consumption of user-generated content, with platforms like Tik-Tok gaining traction. The emergence of useful entertainment, with a special focus on wellness content, will also provide brands with food for thought. Until now, brands have been highly focused on traditional sponsorship models that focused on major physical events. Diversifying away from this model will create even more opportunities for branded content.

6. GREEN ECONOMIC RECOVERY?

Over the last decade, strong progress has been made in terms of raising awareness about climate change. The ecological agenda has made in-roads into politics, the economy and society with a rare level of efficacy thanks to strong warnings from civil and scientific organizations regarding the climate emergency we face. Following the Paris Agreement in 2015, which offered the first global framework for reducing greenhouse gas emissions, the countries involved got to work and were making significant progress. Then came COVID-19, which has put the whole world on pause. In a scenario of economic recession, classic economic theory leads us to conclude that private investment will slow, especially nonessential investment. Similarly, the expectation is that governments ecological agendas will need to be less ambitious, and issues that increase pressure on companies (such as green taxation or political incentives) will be relaxed.

Contrary to this theory, we are seeing a growing phenomenon of pressure to intensify these practices, which may position the ecological revolution as a lever for economic reconstruction. Several European countries have already signed the Green Recovery Alliance. In turn, the European Commission itself has positioned its European Green Deal project as one of the most powerful reactivation tools. The Spanish government also seems to be heading in the direction of ecological reform: It is working on a growth and progress model based on balanced use of renewable resources and on recycling nonrenewable resources. There will, of course, still be a great deal of disagreement with extreme positions on the ecological transition as policymakers seek to leave room for measures that alleviate the economic stress placed on companies.

For the time being, conversation analysis shows a sharp decline in conversations about sustainability and climate change. That is entirely to be expected, as COVID-19 dominates online conversation. When we return to a certain degree of normalcy, perhaps we will see a more polarized conversation. Supporters of the ecological agenda will likely present it as the right way forward, while other groups may become more active in defending the economy/ecology dichotomy.

That same ecological tension can be seen in other layers of the conversation. Many companies will find support for their green positions under these circumstances, and it may be a way to stand out in their category: Fewer processed foods and products, more sustainable production and commercialization processes. This can turn into conversations about how this health crisis is returning our attention to nature and highlight the importance of buying better quality products, even if they are more expensive. However, the economic recession is making buying sustainable products less accessible, as these products are also less affordable.

Plastic products and packaging are an example of this battle. Disposable plastics have proven extremely important to preventing the spread of disease amid a global push to discourage their use because of how they pollute the environment. It is likely that plans to impose a tax on disposable plastics will be delayed, but will eventually move forward. Manufacturers will become polarized, shifting into those that delay their own green revolutions and those that accelerate it because they see it as a commercial opportunity.

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The Covid-19 Effect: Conversation Territories In The New Normal - PRovoke Media

The entertainment industry lights up Las Vegas for Red Alert Restart – Las Vegas Sun

John Locher/AP

Performers cheer as they watch fireworks during a Las Vegas event to raise awareness for entertainers and live event workers who have been out of work since the start of the pandemic, Tuesday, Sept. 1,2020.

By Brock Radke (contact)

Thursday, Sept. 3, 2020 | 2 a.m.

Michelle Johnsons career in Las Vegas is a paragon of what the entertainment and events industry here is all about. Shes an exceptional and accomplished vocalist often referred to as the citys first lady of jazz, but she also produces varied entertainment events and runs a backline and production company with her husband.

Like so many other local professionals, Johnson does a lot of different things in order to make the Vegas magic happen. Thats why she was talking to media at the Smith Center on Tuesday night, a perfect representation of what the Red Alert Restart awareness event was all about.

Las Vegas organizers and venues participated in the national event on the evening of Sept. 1 assembled by brand-new industry organization We Make Events North America. Venues like the Fremont Street Experience, the Space, the Thomas & Mack Center, Allegiant Stadium and the Las Vegas Ballpark were lit in red to show support for the displaced workers in the live events industry, and downtowns Plaza Hotel & Casino hosted a performance from some of those entertainers and a fireworks display at its Core Arena.

But Johnson spent her evening at the Smith Center, where a symbolic road case push circled the Symphony Park lawn to start the events, because the downtown performing arts center holds a special place in her heart.

Ive played here a lot, I love this building and I feel like when this was built, it shifted the way Las Vegas was perceived, she said. I always call this the Lincoln Center of Nevada. Before this it was the Strip and the production shows but now we have true arts here. For all of that to happen in what feels like a short period of time, and then one day its all done [because of the pandemic], thats one thing.

The other thing, and the reason I got emotional when I came out here, is seeing all these stagehands here. Even I dont realize how many people have lost their gigs, and Im in the business. Every show, every property, every hotel has AV [technicians]. And it feels a little like were invisible, the little magic behind the wall no one sees. They just see the performers.

Red Alert Restart was a bit different from other local events and fundraisers benefitting those in the performing arts because the focus is on everyone in the industry an estimated 12 million people across the country, according to organizers.

From performers to technicians to designers to legal staff to the guy working the hot dog stand to the parking attendant, every person involved in making live events happen, said Brad Nelms, a new Las Vegas resident and the national director for We Make Events. We as an industry contribute about a trillion dollars a year in economic impact, plus the tertiary effects on other industries like travel, hospitality and restaurants.

Without audiences we dont exist and thats our challenge right now. We cant have an audience. There is a massive community behind these [events] that has made a living by being out of the picture, behind the scenes, and they now have a big problem, so thats why were doing this.

The North America group formed quickly after the campaign started in Europe with an Aug. 11 Light it Red event that saw the participation of 1,750 buildings. Tuesdays event was organized by regional teams in 58 cities with approximately 2,000 buildings illuminated in red across the country, Nelms said, thanks to the efforts of more than 5,000 volunteers.

Some local industry workers have been attempting to persuade state government and the Nevada Gaming Control Board to create and release guidelines that would allow smaller Las Vegas shows and live entertainment events to get back onstage as soon as possible. But this national campaigns goals are focused on getting more assistance for workers everywhere though two pieces of legislation that Congress could add to the next relief bill.

The Restart Act is small-business legislation thats not exclusive to our industry, but it would be helpful relative to other bills because it provides the loosest restrictions on the amounts of time and money it provides, and that gives us enough runway to get to March, which is the earliest time we believe we can be back, Nelms said. And on the people side, many people in this industry are freelance workers or own their own businesses and theyre not necessarily covered by the Payroll Protection Program. So we need pandemic unemployment assistance and federal pandemic unemployment compensation, the vehicles that were previously giving people that additional $600 per week to make an actual livable wage on unemployment, and allow independent contractors access to that money.

We Make Events also held a livestream on Facebook during this weeks demonstrations and the group encourages supporters to visit wemakeevents.org to find ways to help.

It seems sadly ironic that the entertainment industry, always in the spotlight in Las Vegas and in other cities where showbiz is deeply entrenched in the communitys culture, appears to be misunderstood, overlooked or even ignored in the era of coronavirus.

It feels like this is the epicenter of it, Johnson said. Im from New York and my friends back home are saying the same thing, but the difference is [New York] is not the entertainment capital of the world. Its Wall Street, and its all these other industries that are all affected, but here, this is the jewel in the crown of what we do. This is it.

Especially when something tragic like this is going on, entertainment is always the thing that pulls people through. Think about the movies that came out of the 40s after the war, or the music that came out of the 60s. Anytime theres turbulence, art is what has bridged us and gotten us through, and people have forgotten about us. I really believe were the healers and well help people pull through, and I dont think were the only ones, but we need to be taken more seriously as part of this city, for all that we give.

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The entertainment industry lights up Las Vegas for Red Alert Restart - Las Vegas Sun

Las Vegas woman arrested for sexually assaulting girl she had met several years ago – KTNV Las Vegas

LAS VEGAS (KTNV) A 24-year-old Las Vegas woman has been arrested for sexually assaulting a child she met several years ago outside of a local school.

Yuliza Ambriz was booked on Aug. 27 in the Clark County Detention Center under the charges of 2 counts of sexual assault against a child under the age of 14 and child abuse and/or neglect.

Las Vegas police discovered the alleged abuse after responding to a domestic disturbance in downtown Las Vegas on July 20.

The juvenile girl was transported to a local hospital where she told a nurse that she was in a relationship with Ambriz.

The girl told police that she met Ambriz outside a school and that Ambriz had a puppy with her at the time. Ambriz reportedly invited the girl and her sister back to her home to play with her other dogs.

The girl and Ambriz became friends and started dating years later. The girl told police that she and Ambriz had several sexual encounters. She repeatedly referred to Ambriz as her girlfriend.

Ambriz confessed to having sex with the girl after she was arrested. She told police that she had feelings for the girl that she could not let go and she knew that the girl felt the same about her.

Ambrizs husband is currently serving time for sexual assault of a child, according to court records.

The domestic disturbance was a result of the girls sister going to Ambrizs home to pick the girl up.

According to the arrest report, the girls mother and sister were aware of the relationship and had made attempts to put an end to it.

Ambriz is due in court Oct. 1.

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Las Vegas woman arrested for sexually assaulting girl she had met several years ago - KTNV Las Vegas

What will it take to bring back Las Vegas shows? – Las Vegas Weekly

Hundreds of Las Vegans who normally spend their time and talents entertaining millions of visitors every year returned to the Strip on August 19 to remind everyone that theyre still here and waiting to get back to work. They drove along Las Vegas Boulevard in their own cars and marched along the Strips sidewalks, wearing masks and holding signs that read We are stagehands, We are performers, We are live music, We make events and We need help.

Matt and Angela Stabile were there. The couples Stabile Productions company created and produces three successful, long-running late-night revuesX Burlesque, X Rocks and X Countryat three different Caesars Entertainment casino properties, along with Piff the Magic Dragon at the Flamingo. They also recently launched Change.org petition The Show Must Go On, calling on Gov. Steve Sisolak to release guidelines allowing shows like theirs to resume operations. At press time, it had more than 4,000 signatures.

It was good to see so many people come out to bring awareness to the fact that nothing is being done, says Angela Stabile, a former showgirl and dancer who performed in Lido de Paris at the Stardust and Crazy Girls at the Riviera. The governor is not addressing anything having to do with ticketed entertainment coming back when almost everything else is.

Adds Matt Stabile, I just dont understand why entertainment has been put so much on the back burner, because no one is going to continue to come to this town without entertainment.

Vegas shows big and small on and off the Strip, along with other events and large gatherings, have been shut down since mid-March as part of the states coronavirus response plan. Theres widespread recognition that the large-scale shows, entertainment and sports events with audiences of thousands cannot safely return at this time, but theres rising frustration in the local entertainment community that events in smaller theaters and showrooms arent getting a fair shake.

Producers of Strip shows like Opium at the Cosmopolitan and Thunder From Down Under at Excaliburheld in venues that seat hundreds, not thousandshave been preparing for months to restart with smaller, socially distanced audiences, modifying productions for any anticipated restrictions. The economics still need to be worked out with the hotels but we can run at 50 percent [capacity], Matt Stabile says. We have an advantage in smaller theaters. Those huge Cirque [du Soleil] shows have it a lot tougher.

Spiegelworld announced in early August that it had deep-cleaned and reconfigured the tent at Caesars Palace that hosts its award-winning show Absinthe, installing a new bipolar ionization air purification system to reduce airborne contaminants and replacing rows of seats with a cabaret-style system allowing a properly distanced audience of 220.

We have a full-time infection mitigation manager onboard who has been consulting with health experts and our casino partners to create a comprehensive handbook and set of protocols for how we will operate once Governor Sisolak and the Nevada Gaming Control Board agree it is appropriate for live entertainment to resume, Spiegelworld founder Ross Mollison said in an announcement. With many enhanced precautions and procedures in place, we believe we are uniquely positioned to present our same raunchy and hilarious shows in a way that should make everybody involved comfortable.

Movie theaters across the Vegas Valley have reopened, including some in casino complexes, leaving entertainers and show workers to watch as crowds gather in similar venues while they cant go back to work in the same fashion. Sophisticated live entertainment is allowed at the Cosmopolitans Rose. Rabbit. Lie. and Bellagios Mayfair Supper Club because those venues are categorized as restaurants, and off the Strip, large church services often include live performance from a full band.

A statement sent from the governors office to the Weekly didnt specifically address that apparent disparity, reiterating that the virus and its impact on the state sets the timeline for any reopening:

The Governor created the COVID-19 Mitigation and Management Task Force, and [it is] responsible for assessing transmission risk levels for each county based on state criteria, and working with local governments to implement targeted mitigation measures that go beyond the current statewide baseline standards. These statewide standards include limits on public and private gathering size, along with capacity limits for businesses. Restrictions and mitigation measures related to live events and performances are also part of the existing statewide baseline standards. Any changes would only occur after an assessment by health officials and other experts and confidence that trends in cases, hospitalizations and community spread are in a safe position, along with appropriate response measures in place.

The August 19 Strip demonstration was organized by an informal group called We the Entertainment Community of Las Vegas (WE/EC), which linked up with new national organization We Make Events North America for a September 1 Red Alert Restart event. Several entertainment and event venues, including Allegiant Stadium, the Las Vegas Ballpark and the Smith Center, were lit in red, with a performance and fireworks display at the Plaza among the happenings designed to raise awareness for at-risk live events industry workers. Similar demonstrations took place in dozens of cities across the country.

The Stabiles have been communicating with Congresswoman Susie Lee and hoping that connection plus their petition will get the attention of the governor. Angela Stabile says she believes everyone is on the same page and wants to get entertainment going as soon as possible.

Caesars Entertainment is a great partner to us. We love working with them and weve been in touch the entire time, she says. Their priority, obviously, is safety, as is ours. The bottom line is we just want some guidelines.

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What will it take to bring back Las Vegas shows? - Las Vegas Weekly

How long will the rise of bicycling last? – Las Vegas Sun

By Andrew Woods

Friday, Sept. 4, 2020 | 2 a.m.

Lockdowns and stay-at-home orders from Las Vegas to London to Beijing have resulted in fewer cars on roads and a plummet in public transit ridership. The nosedive in daily commuters has left large swaths of cities around the world nothing but a sea of deserted asphalt in the middle of the day. Among those who did venture out, many opted for a form of transit most of us learned to use as children bicycles.

According to the Regional Transportation Commission of Southern Nevada (RTC), use of the bicycle share program in downtown Las Vegas skyrocketed 97% the past few months compared with the same time last year. In May, the e-bike share program saw an average of a 1,000 rides a day, an increase of 843% compared with May 2019.

Venturing out, one couldnt help but notice the throngs of bicyclists on some of what used to be our busiest roads, such Sahara Avenue at Las Vegas Boulevard. The jumps in ridership in Las Vegas follow similar trends in other major cities.

Eco-Counter a Montreal engineering company that measures pedestrian traffic found a 21% increase in overall U.S. urban ridership thus far this year, compared with 2019. In New York City, the bike-share service Citi Bike saw an increase of 67% at the beginning of March, which continued through June, the latest data available. Counters on bridges measured significant increases in bicycle crossings at the start of the pandemic before stay-at-home orders were issued. Rails-to-Trails reported a 110% increase over 2019 in ridership on rail-trails such as sections of the Great American Rail Trail that connects Washington, D.C., to Seattle.

The upward trend is not just in metropolises with robust ridership, but also in car-dependent western cities like Los Angeles and Oakland, where ridership and bicycle sales in the wake of coronavirus skyrocketed. Data provided by PeopleForBikes showed bicycle sales up 65% this year over 2019. In many cities, there is a shortage of new bicycles because suppliers have not been able to keep up with demand.

Ridership has increased for several reasons. For one, during the pandemic people feel safer on their bicycle than on public transit. It is deemed relatively safe when riders maintain 6 feet of distance from each another, and research suggests that coronavirus transmission is more difficult in outdoor settings and when people are moving at variable speeds. Cycling has been deemed so safe and economically necessary that the U.K. government included bicycle repair vouchers in its economic recovery plan.

Second, with more people spending time at home, families are looking for something to do together that keeps the kids entertained and gets them out of the house. According to Eric Bjorling, director of brand at Trek Bicycles, this has led to not only a shortage of childrens bicycles, but all kinds of bicycles, from electric-powered to mountain bikes, for adults who are eager to get outside.

Cities are taking notice. Local governments in New York, Milan, Paris, Mexico City, Bogota and, yes, Las Vegas are accelerating plans for new bicycle lanes. They are meant to be temporary or pop-up to adjust for the significant change in urban commuter habits, but city planners and bicycle advocates are thinking longer term. Some dream of what they call the 15-minute city, where food, parks and schools are within a 15-minute walking distance, and the current crisis has allowed city leaders to fast-track those plans.

Clark County Commissioner Justin Jones, a cycling advocate, notes that already several new bicycle lane projects in the valley have been fast-tracked, including a multiuse trail from Hualapai Way to Durango Drive that will extend the future Red Rock Legacy Trail, as well as additional miles of bike lanes on Fort Apache Road and restriping of new lanes on Torrey Pines Drive.

Prior to COVID, Clark County was making slow, steady progress to add more bicycle lanes, Jones said. COVID proved that if people feel safe, they will get out and ride a bike on our roadways. Now, more of these projects that make cycling more accessible are moving forward with greater emphasis.

Jones and others are looking to take advantage of the enthusiasm in bicycling with an annual event starting this fall and a possible future event on the Strip once restrictions on social gatherings are lifted.

In downtown Las Vegas, RTC partnered with NV Energy to build six more e-bike sharing systems after demand skyrocketed during the state-mandated shutdown. RTC notes that its e-bike program has remained popular even after the shutdown and in the midst of extreme heat. It predicts that by the end of the year, the number of e-bike share rides will double what they were 2019.

Will it last? While advocates are bullish that the pandemic will change commuters habits for the long term, others are more skeptical over whether habits have actually changed in car-heavy communities. Part of the skepticism is that planners have rushed through new projects that normally take several years to put together. In New York, residents in Central Park West sued the city last year over the construction of the bicycle lanes. City planners worry that even if habits shift to using less public transit and more bicycling, other commuters will still choose cars, causing further congestion and smog on narrower roads.

One thing is clear though: Whether or not COVID-19 has changed the habits of urban commuters, cities are pedaling forward.

Andrew Woods is the CEO of WS Nevada a policy, elections and analysis firm based in Southern Nevada. He is finishing up his masters at the University of Chicago with a focus on infrastructure and transportation.

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How long will the rise of bicycling last? - Las Vegas Sun

Projecting the Raiders’ 53-man roster – Las Vegas Sun

Saturday is cut-down day, when the Raiders will have to narrow their roster to the 53 players they intend to take into their Week 1 matchup against Carolina, and Jon Grudens philosophy toward building the roster is simple.

When asked about his cornerback group in the wake of releasing veteran Prince Amukamara, the coach gave an answer that covers just about everything.

Keeping the best guys is all were doing, Gruden said. Were going to keep the best players and try to continue to develop them.

With that guiding principle, lets run through the roster and try to project Las Vegas 53-man allotment.

(And for the sake of fun, lets also look back at my colleague Case Keefers first 53-man projection, which was done immediately following the draft but still holds up reasonably well.)

QUARTERBACKS (3): Derek Carr, Marcus Mariota, Nathan Peterman

Carr calmed some nerves around the franchise by playing well enough in camp to extinguish any talk of a quarterback controversy before it got started. Mariota, by the virtue of his high salary and not necessarily his performance in camp, will be the No. 2 QB. Some teams only carry two passers, but with COVID-19 complicating things the safe play would seem to be three quarterbacks. Peterson gets the last spot.

Cases early projection: Carr, Mariota, DeShone Kizer. Kizer didnt last long. There must be something about Peterson that Jon Gruden finds endearing.

RUNNING BACKS (4): Josh Jacobs, Jalen Richard, Lynn Bowden, Alec Ingold

Jacobs is a stud and should handle the vast majority of the workload on first and second down. Richard and Bowden are pass-catchers at this point, and Ingold is a fullback. If theres one thing this group is missing its a hard-charging power back for short-yardage situations, but Ingold can theoretically lead the way in heavy formations.

Cases early projection: Jacobs, Richard, Bowden, Ingold. Nailed it. Maybe I can take the rest of the night off

WIDE RECEIVERS (5): Henry Ruggs, Hunter Renfrow, Bryan Edwards, Nelson Agholor, Zay Jones

The Raiders probably would have carried six receivers if Tyrell Williams hadnt gone on injured reserve, but he did and now the team is a bit short-handed at the position. I dont think there was another wideout in camp who could step up into the sixth spot, so I project the Raiders to roll with five WRs to start the year. Agholor and Jones are now key pieces.

Cases early projection: Williams, Ruggs, Renfrow, Edwards, Agholor, Jones. This is likely dead on if Williams had made it through the summer healthy.

TIGHT ENDS (4): Darren Waller, Foster Moreau, Jason Witten, Derek Carrier

Carrier wouldnt have made the imaginary cut a week ago, but with Williams situation trimming the number of receivers on the roster Gruden now gets to carry a fourth tight end. For those of you keeping score at home, thats four tight ends and a fullback on a 2020 roster.

Cases early projection: Waller, Witten, Moreau. This could still end up being the way things shake out on Saturday. The skill sets of Waller, Witten and Moreau are varied enough that they could handle just about every conceivable situation.

OFFENSIVE LINEMEN (10): Rodney Hudson, Gabe Jackson, Richie Incognito, Kolton Miller, Trent Brown, Denzelle Good, Sam Young, John Simpson, Brandon Parker, Andre James

The top five are locked in, and Simpson was a fourth-round draft pick so his spot is secure. Good gives the team a veteran guard, and Parker is still developing on the outside. One point of concern is Browns absence for most of camp; if hes unable to get up to speed in time for Week 1, Young would probably get the call to step in at right tackle. Hudson has played 100 percent of the teams offensive snaps in three of the last four seasons, but James has shown enough to warrant a spot as the backup center.

Cases early projection: Hudson, Jackson, Incognito, Miller, Brown, Jordan Devey, Eric Kush, Simpson, Good, David Sharpe. The second-string picture has changed since the draft. Devey was released this week, Sharpe was traded to Washington for a late-round pick and Young was a relatively late addition.

DEFENSIVE LINEMEN (8): Clelin Ferrell, Maxx Crosby, Arden Key, Carl Nassib, Maliek Collins, Johnathan Hankins, Daniel Ross, Maurice Hurst

Ferrell and Crosby will start on the outside and Collins will line up as the three-technique DT. The other tackle spot will probably end up being a rotation depending on the situation. Key showed out during training camp, so it will be interesting to see if he can carry it over to the regular season.

Cases early projection: Ferrell, Crosby, Nassib, Key, Collins, Hankins, Hurst, Ross, P.J. Hall. Hall didnt make it through camp, but the rest of the eight remain the same.

LINEBACKERS (6): Nick Kwiatkoski, Cory Littleton, Raekwon McMillan, Nicholas Morrow, Javin White, Tanner Muse

McMillan gives the team a third starting-caliber linebacker, but only in run situations. Morrow makes the team as a sub-package LB, with undrafted White pushing him for playing time. Muse is a linebacker in name only, as hell see most of his snaps on special teams.

Cases early projection: Kwiatkoski, Littleton, Morrow, Muse, Marquel Lee. White was the biggest riser during training camp, so its understandable that Case left him off of the early 53-man roster.

CORNERBACKS (6): Trayvon Mullen, Damon Arnette, Lamarcus Joyner, Amik Robertson, Isaiah Johnson, Keisean Nixon

This position group is an indication of the franchises youth movement. Arnette and Robertson are rookies, while Mullen, Johnson and Nixon are second-year players. Joyner is the only certified veteran in the room. Nevin Lawson is serving a suspension in Week 1 but hes another experienced hand.

Cases early projection: Mullen, Arnette, Joyner, Robertson, Nixon, Lawson. As mentioned, Lawson will be eligible to rejoin the team in Week 2, so this could end up being the true composition at cornerback.

SAFETIES (4): Johnathan Abram, Damarious Randall, Jeff Heath, Erik Harris

One of the most spoken-for position groups, this has looked like the foursome throughout the entire offseason. The team is expecting big things from Abram, while Randall, Heath and Harris should combine to provide steady play on the back end. Probably the only way this changes is if Gruden moves Lamarcus Joyner to safety.

Cases early projection: Abram, Randall, Heath, Harris. No fuss, no muss.

SPECIAL TEAMS (3): Daniel Carlson (kicker), A.J. Cole (punter), Trent Sieg (long snapper)

Carlson hasnt been rock-solid during his time with the Raiders, but if theres a last-second kick to win the game in Week 1 hell be the one lining it up.

Cases early projection: Dominik Eberle (kicker), Cole, Sieg. Eberle was an interesting undrafted free agent, but he ended up being one of the first camp cuts.

Mike Grimala can be reached at 702-948-7844 or [emailprotected]. Follow Mike on Twitter at twitter.com/mikegrimala.

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Projecting the Raiders' 53-man roster - Las Vegas Sun

Carbone in Las Vegas is rich in flavor and tradition – Lasvegasmagazine

If youre in the mood to go old school, hit up Carbone. This restaurant channels the Italian joints New York is famous for. Youll dig its plush, high-backed booths and velvet curtains around the dining area, as well as the eclectic playlist.

Start with a classic cocktail like the Negroni, simply concocted with London gin, vermouth and Campari, or a fancy one like the White Lady, with gin, orange liqueur, vanilla and egg white. Num-num. Add an appetizer, such as the carpaccio Piemontese, which Carbone is known forthin slices of lean beef, with a truffle emulsion, mushrooms and arugula.

Another Carbone classic, the rigatoni in spicy vodka sauce, lives up to its name. Youll probably suss out Calabrian chili, as well as plenty of onion. And a medium-rare ribeye Diana with a cacciatore-style sauce may float your boat as well.

Aria, 877.230.2742

Click here for your free subscription to the weekly digital edition of Las Vegas Magazine, your guide to everything to do, hear, see and experience in Southern Nevada. As part of your subscription, each week via email you will receive the latest edition of Las Vegas Magazine, full of informative content such as restaurants to visit, cocktails to sip and attractions to enjoy.

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Carbone in Las Vegas is rich in flavor and tradition - Lasvegasmagazine

Attempts to halt Kremlin critic Navalny have failed so far – Las Vegas Sun

Alexander Zemlianichenko / AP

In this Dec. 26, 2019, file photo, Russian opposition leader Alexei Navalny speaks to the media in front of a security officer standing guard at the Foundation for Fighting Corruption office in Moscow, Russia. Navalny has been poisoned and hospitalized on Thursday morning, Aug. 20, 2020. His spokeswoman said on Twitter that Navalny felt unwell on a flight back to Moscow from Tomsk, a city inSiberia.

Associated Press

Friday, Sept. 4, 2020 | 12:30 a.m.

MOSCOW All the attempts over the years to stop the work of Kremlin critic Alexei Navalny have failed so far.

Hes been jailed repeatedly and twice put on trial for embezzlement and fraud. He's been put under house arrest and splashed in the face with green antiseptic, damaging his sight. He was hospitalized last year for a suspected poisoning while in custody. His brother was jailed for over three years on fraud charges.

Now Navalny is in an induced coma in a Berlin hospital after suffering what German authorities say was a poisoning with achemical nerve agentwhile the opposition leader and corruption fighter was traveling from Siberia on Aug. 20. The Kremlin has denied involvement, and questioned whether he was poisoned at all.

Initially stunned by the attempt on his life, his supporters soon got back to work on their latest campaign against the government of Russian President Vladimir Putin.

Weve got more anger and more motivation to work harder in order to, among other things, show the Kremlin that these methods of pressuring the opposition dont work, said Lyubov Sobol, one of Navalnys closest allies.

His top strategist Leonid Volkov said Navalny's team put all their regular work on hold as they arranged his transfer from a hospital in Omsk, where the plane carrying the unconscious activist had made an emergency landing. They publicized his plight for 48 hours, from the moment the plane landed in Omsk to the minute when the medevac plane carrying Navalny took off for Berlin.

Starting from Sunday, when he was already in Berlin, I firmly told everyone and everyone understood, of course that, Guys, Im sorry but we need to get back to our normal work,' Volkov said. Weve got to slog away at Smart Voting.

The Smart Voting project was launched in 2018 and is designed to oust the Kremlins dominant United Russia party which Navalny has dubbed the party of crooks and thieves from regional governments and legislatures.

The project aims to identify and campaign for candidates who are most likely to beat those backed by the Kremlin in various elections.

Last year, the Smart Voting project helped opposition candidates win 20 out of 45 seats on the Moscow city council. This year, Navalnys team hopes to use it in 31 Russian regions where elections on various levels are scheduled for Sept. 13. In some of those regions, the team put forward its own candidates.

Navalny, 44, has been a thorn in the Kremlin's side even though he is barred from running against Putin because of the 2017 conviction for embezzlement a charge he says was politically motivated. In public statements, Putin refuses to even speak Navalny's name.

Through his two popular YouTube channels detailing government corruption, Navalnys reach has spread across the vast country. In 2017, he set up a network of campaign offices in a bid to challenge Putin in the 2018 presidential election. Even though he was banned from running against Putin, Navalny kept the infrastructure in place.

These regional headquarters began their own investigations of graft by local officials and recruited activists, some of whom would later run for office. Navalny believes that ending the dominance of United Russia in regional parliaments and administrations will undermine the formal mechanism of Putins rule.

After Navalny was hospitalized in Germany, his team used the moment to promote Smart Voting, filling social media with calls to register on the projects online platform that tells voters which candidates to support in their area. Volkov said the appeals have increased registrations.

On Monday, they released a 40-minute expose of corruption in Novosibirsk, a large city in Siberia where a coalition of over 30 opposition candidates is running for the city council. The video, which has gotten over 4 million views on YouTube, was shot during Navalnys fateful trip to Siberia.

The foundation of Putins power is not the State Duma, as one would think. No," Navalny says in the video, stressing the importance of the local elections.

Their main power is in United Russia having a majority in every regional legislature and a majority in every big city council. If (United Russia) loses this majority, the power of the villains melts away immediately, he says.

From these regional roots, Navalnys team hopes to go all the way to the State Duma -- Russias lower house of parliament -- and deploy the Smart Voting strategy in the 2021 parliamentary election.

Its a dress rehearsal, a decisive test of strength before the elections to the State Duma, Volkov said.

Navalnys ability to mobilize voters next year poses a key challenge for the Kremlin, because those elections will determine who controls the State Duma in 2024. That's when Putins current term expires and he is expected to seek re-election, thanks to a reset of his term limits after lawmakers and voters approved changes to Russia's constitution this year. And Putin's approval ratings have fallen recently amid growing public frustration over the declining economy.

The Smart Voting strategy could indeed upend government plans for the new parliament, said Nikolai Petrov, a senior research fellow in Chatham Houses Russia and Eurasia Program, but he said Navalnys personal involvement is crucial.

Navalny is unique because no one but him has enough authority to consolidate votes for various non-Kremlin forces and ensure defeat of the Kremlins candidates, Petrov said.

Still, Navalny has built an organization that goes beyond the appeal of one man. With him jailed so often, his supporters are used to working on their own, as is his network of over 40 regional cells nationwide.

Navalny was imprisoned for 30 or 50 days last year, and the work didnt stop. Its the same now. Yes, of course, it was a shock for us, but we didnt stop our campaigns, said Ksenia Fadeyeva, who runs the regional headquarters in the Siberian city of Tomsk and is running for city council.

At the same time, his supporters admit that his charisma and popularity are an asset, even though his anti-corruption campaigns have angered many in power even outside the Kremlin.

Tomsk was one of Navalnys stops on his recent trip to Siberia. Fadeyeva says she was pleasantly surprised by how well he is known.

We walked around the city center, and a lot of people recognized him. To be honest, I didnt expect that many people to approach (Navalny), say hello, ask for a photo, want to talk, Fadeyeva said.

A 40-minute video exposing corruption in Tomsk was released Thursday by Navalny's team, and in five hours received over 850,000 views.

We dont hide that our political organization vast and sophisticated is built around a charismatic leader, which is both a strength and a weakness, Volkov said. A leaderless protest cant be beheaded, but it is much harder for a leaderless protest to succeed.

Volkov admits that hardly anyone on the team has as much political capital or could rally people like Navalny, who could come up with thoughts and ideas that were interesting to a lot of people, as well as effective forms of communication.

The Kremlin understands that, and it understands that with ... one horrific criminal act it can try and nullify a significant part of what weve done, he added.

In the meantime, theres no other option but to continue the work.

You do what you can. We campaign the way we can," Volkov said. "We invest all the resources that we have. And we do what we do.

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Attempts to halt Kremlin critic Navalny have failed so far - Las Vegas Sun

Las Vegas casinos-unions agree on health benefits extension into 2021 – Yogonet International

F

ollowing months of negotiations over worker safety and job protections which begun when casinos were closed in mid-March because of COVID-19, tens of thousands of working or furloughed employees at MGM Resorts and Caesars Entertainment will keep family health benefits until March 1.

An agreement was reached Monday between the two largest Las Vegas casino companies unions representing bartenders and culinary workers, officials said. The pact affects about 36,000 union workers at 22 Las Vegas Strip properties, the unions said.

As reported by FOX 5, the agreement came the same day casino giant MGM Resorts International laid off about 18,000 employees at locations around the U.S.

Behind every worker is a family, Culinary Union executive Geoconda Argello-Kline said in a statement describing the agreements with MGM Resorts and Caesars Entertainment Inc. as historic.

Argello-Kline said they mean workers can keep health benefits until next year even if they are currently idled, and retain seniority benefits when they return to their jobs.

In the statement, Tom Reeg, Caesars CEO, called the agreement an important step in continuing to ensure our team members and their families are protected during these unpredictable times.

Our industry and communities are facing unprecedented challenges MGM Resorts CEO and President Bill Hornbuckle added in the statement.

In a separate letter to company employees who went from furloughed to laid-off on Monday, Hornbuckle said MGM Resorts would extend their health benefits through Sept. 30; that they would remain on a recall list; and that those reinstated by the end of 2021 would retain seniority and resume benefits.

Most Las Vegas casinos have reopened since closure orders were lifted June 4.

The unions representing hotel housekeepers, cooks, bartenders, vehicle valets and others sued MGM Resorts and Caesars later that month, seeking to force the companies to tighten safety measures to protect employee health.

On June 24, Nevada Gov. Steve Sisolak issued a mandatory face-covering policy for any generally publicly accessible space including casinos and other businesses.

The state Legislature later passed a law requiring enhanced hotel and casino cleaning and safety training; enforcement of social distance requirements; temperature checks to detect fever symptoms of illness; and detailed plans for when a worker contracts the virus.

The claims in the lawsuit were dismissed in August.

The culinary and bartenders unions said Mondays agreement affects 24,000 MGM Resorts workers and 12,000 Caesars employees. It said officials were trying to negotiate similar protections for 24,000 employees at other Las Vegas-area hotels and casinos.

The companies promised 10 paid days off for employees ordered to be quarantined by local health officials; no disciplinary action against workers isolated with COVID-19 symptoms; up to six weeks of unpaid leave; and a chance for employees to switch jobs if positions become open.

Tourists and travelers are beginning to return to Las Vegas, according to economic reports, but mostly by highway and well below pre-coronavirus levels.

With conventions canceled, the regions nearly 124,000 hotel rooms were less than half-full in July, and overall visitor volume was down 61%, the Las Vegas Convention and Visitors Authority reported last week.

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Las Vegas casinos-unions agree on health benefits extension into 2021 - Yogonet International

Richie Incognito finds redemption in silver and black – Las Vegas Review-Journal

Richie Incognito went searching for redemption last year. The veteran NFL guard discovered it in a franchise that has time and again offered players opportunity for a brighter tomorrow. Second and sometimes more chances. Its the Raiders Way.

It was at training camp last season when Incognito answered questions about issues with the law and locker room bullying at previous NFL stops. About incidents that called into question his mental health. About all those demons he fought daily.

Now, inquiries have taken a much different tone: Simply, how at age 37 will he follow what was one of the best seasons of his career.

Few were better

The positives from a 7-9 record are few, but Incognito stood on an efficient side of the ledger. The Raiders signed him to a one-year deal in May of 2019, a central reason being they needed to upgrade his position and believed he could still play at a four-time Pro Bowl level.

At the end of the day, Raiders general manager Mike Mayock said at the time, you cant have all Boy Scouts Were all going to take ownership with Richie. The expectation is for him to not only be a good football player, but to be a really good human being. Its a two-way street weve got to help him help himself.

Last December, Incognito signed a two-year extension with a base salary of $5 million and incentives that could push the yearly total beyond $6.3 million. It seems he did his part.

There were few better guards in the NFL last season, but talent has never been an issue with Incognito. His is as massive as his 6-foot-3, 322-pound frame.

Even after missing the 2018 season, one in which he retired, un-retired and then was cut by the Bills, his production was nearly unparalleled in 2019: According to Pro Football Focus, Incognito had a single-season best pass-blocking rate of 88.5.

He allowed just one sack and nine pressures on 414 pass-blocking snaps. That is astaggeringly low failure rate of 2.2 percent, which trailed only Marshal Yanda of the Ravens among qualifying guards.

Yanda, by the way, retired in March and will eventually receive a Hall of Fame bust.

You know, its been great, Incognito said of his time with the Raiders. I was really blown away by the support (Mayock) and (head coach) Jon Gruden threw behind me. I was able to come in and be myself. Guys got to know me, and my role as a leader has grown on this team. It has been special. I just want to be the same guy I was last year.

It was vindicating. I had a tumultuous year off. I had to fight back from a lot. I came in and really just ingrained myself in the organization. It had my back. Im forever grateful to the organization for giving me an opportunity. Now its just time to go out there and kick some ass.

Las Vegas ready

He can always be more disciplined. Incognito has been fined more than $700,000 in his career, including suspensions. Of his eight penalties last year (tied for fourth-most among NFL guards), he was docked $21,054 for a chop block and unnecessary roughness against the Bears in London. Then, a late holding penalty at Houston took the Raiders out of field-goal range. They never possessed the ball again and lost 27-24.

But he has fit with the Raiders far better than most imagined. There is also this interesting storyline: Incognito and his father, who passed away in 2018, bought property in Las Vegas three years ago. Their plan was to attend games at Allegiant Stadium once Incognito retired for good.

Now, the son will be playing in it.

We were just going to go and cheer for the Raiders, he said. I took 2018 off and realized I still loved football. Coach Gruden was in my ear about playing. He already got me to come out of retirement and it couldnt have worked out any better. Vegas was always in the cards for me.

Redemption in Sin City. You cant make these things up.

Ed Graney is a Sigma Delta Chi Award winner for sports column writing and can be reached at egraney@reviewjournal.com or 702-383-4618. He can be heard on The Press Box, ESPN Radio 100.9 FM and 1100 AM, from 7 a.m. to 10 a.m. Monday through Friday. Follow @edgraney on Twitter.

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Richie Incognito finds redemption in silver and black - Las Vegas Review-Journal

Seniors are in the crosshairs – Las Vegas Sun

By Don Martin, Las Vegas

Friday, Sept. 4, 2020 | 2 a.m.

Many people say this is the most important election in 90 years. This is especially true for seniors. The problem is, most seniors have no idea what President Donald Trump has in store for them in his proposed 2021 budget.

Now that Trump has started paying out over $1 trillion in tax giveaways for corporate cronies and wealthy contributors, he plans to make seniors pay for it. In his 2021 budget, Trump plans to slash $756 billion out of the earned benefits seniors have accrued over a lifetime of building this great nation.

While Trump is in the courts trying to erase the last vestiges of Obamacare, he has broken his promise of offering the best health care plan ever. He is returning Americans to enduring the fear of being denied coverage over preexisting conditions, medical bankruptcies and death for those turned down as insurance ineligible for any care.

Trump also has plans to cut Social Security and severely eviscerate Medicaid, which seniors turn to when a retirees money runs out.

Joe Biden, on the other hand, would peel back those corporate tax breaks and increase Social Security annual payments by $6,500, taking 500,000 seniors out of poverty by 2030. Biden, like any good Democrat, will never cut the senior safety net, because thats not what Democrats do.

As a senior myself, who has started and run many businesses honestly, paying all my taxes, I find it inconceivable that I must face old age in fear of living in poverty.

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Seniors are in the crosshairs - Las Vegas Sun

Raiders driving force Carl Nassib feels at home with his hand in the dirt – The Mercury News

Carl Nassib likes everything about his new home in Las Vegas except for being behind the wheel.

I have to drive like Vin Diesel in `Fast and Furious to stay alive, the Raiders defensive end said Thursday via Zoom teleconference. Craziest drivers Ive ever seen in my life.

If Nassib can drive like he plays football, he wont lack for effort. Nassib knows only one speed, so assume hell be cutting across lanes of traffic on two wheels if thats what it takes to reach his destination.

Its that quality that drew the Raiders to Nassib during free agency, as they shelled out a reported guarantee of $17 million in a three-year contract worth a maximum value of $25 million.

Well, that plus the fact that hes 6-foot-7 and 275 pounds.

Want to know why the Raiders didnt pursue Yannick Ngakoue and havent made a move toward the available Jadeveon Clowney? Because they believe putting Nassib on the edge is the antidote to a mediocre pass rush even if he spends as many defensive snaps on the sideline as he does on the field.

Over the last two seasons with the Tampa Bay Buccaneers, Nassib played in a 3-4 defense as an outside linebacker. Sometimes he rushed while standing up. Sometimes he put two hands on the ground and split wide. He even chased receivers downfield on occasion and broke up the occasional pass.

Nassibs leap-off-the-screen effort level made him a fan favorite, even as he realized his role with the Bucs wasnt necessarily suited to his strengths.

Im really excited to be playing the position I feel like Im meant to play, being a 4-3 D-end, Nassib said. I have my hand in the dirt I had to make a lot of adjustments going to outside linebacker.

The signing for the Raiders was viewed in some circles as a reach. Nassib had 12 1/2 sacks over the past two seasons in Tampa Bay, playing roughly half the snaps. The Raiders made him their highest-paid defensive lineman at an average salary of $8.33 million per year.

But given the going rate for edge players, it wasnt really out of line. Nassib will be getting about half what the No. 10 player at his position receives. Considering how hard Nassib competes, being an every down player would reduce his effectiveness rather than enhance it.

All of which makes Nassib perfect for the philosophy of new defensive line coach Rod Marinelli, who values effort and hustle above all else. Both Nassib and second-year end Maxx Crosby are off the charts in terms of getting after it, a quality they believe can create a ripple effect amongst the front four.

I guess you could say its contagious, Nassib said. I personally would say its a standard that (Marinelli) sets, and he does not waver off the standard.

The Raiders system should keep Nassibs snap count about where it was with the Bucs, subbing in and out with Crosby, Clelin Ferrell and Arden Key as outside rushers, with Ferrell moving inside on occasion along with Maliek Collins Johnathan Hankins, Maurice Hurst and Daniel Ross.

While the Raiders improved their pass rush a year ago, going from an appalling 13 sacks to 32, the fact is their jump was from 32nd to a tie for 25th. Theyre still 15 to 20 sacks from being truly formidable. This years opposition includes Patrick Mahomes (twice), Drew Brees, Tom Brady, Cam Newton, Matt Ryan and Philip Rivers, all looking to prey upon a young secondary but needing the time to succeed.

Thus the Raiders are hoping for a centipede effect and fresh legs to apply pressure.

You dont want any dropoff, Nassib said. You want to consistently get after it, consistently pressure. I think were going to do that here.

Nassib, 27, has a prove it mentality borne of being an angular 6-foot-6, 218-pound walk-on at Penn State, before ascending to a scholarship and then being honored as the Big Ten Defensive Player of the Year and the Ted Hendricks Award as the best defensive end in college football.

A third-round pick by the Cleveland Browns, Nassib was inexplicably cut after two seasons, the second of which the Browns were 0-16.

Tampa Bay claimed Nassib on waivers, and once there he formed an opinion of Jon Gruden from a distance.

I never had met him personally but playing in Tampa, you hear about him, Nassib said. The whole town still loves him.

Gruden, combined with Marinelli, a better scheme fit and a huge paycheck, turned out to be a winning hand.

The cards all matched up and Im really happy to be here, Nassib said.

Speaking of cards, Nassib isnt much for games of chance while residing in a city that is famous for them. When it comes to money, Nassib is all about compounding interest, and he even gained a measure of fame on HBOs Hard Knocks with the Browns for giving his teammates a seminar on camera. Hes attempted to educate some of his Raiders teammates as well.

I hate gambling, Nassib said. Ive given little spreadsheets, one-page documents, to teammates, just the basics, and Ive had multiple conversations. I love it. I love hearing about that kind of stuff. Its not about how much you earn its about how much you save.

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Raiders driving force Carl Nassib feels at home with his hand in the dirt - The Mercury News

What to expect on AREA15’s Sept. 17 opening day in Las Vegas – FOX5 Las Vegas

'); $("#expandable-weather-block .modal-body #mrd-alert"+ alertCount).append(""+val.title+""); // if (window.location.hostname == "www.kmov.com" || window.location.hostname == "www.kctv5.com" || window.location.hostname == "www.azfamily.com" || window.location.hostname == "www.kptv.com" || window.location.hostname == "www.fox5vegas.com" || window.location.hostname == "www.wfsb.com") { if (val.poly != "" && val.polyimg != "") { $("#expandable-weather-block .modal-body #mrd-alert"+ alertCount).append('"+val.ihtml+""); $("#expandable-weather-block .weather-index-alerts").show(); $("#expandable-weather-block .modal-body h2").css({"font-family":"'Fira Sans', sans-serif", "font-weight":"500", "padding-bottom":"10px"}); $("#expandable-weather-block .modal-body p").css({"font-size":"14px", "line-height":"24px"}); $("#expandable-weather-block .modal-body span.wxalertnum").css({"float":"left", "width":"40px", "height":"40px", "color":"#ffffff", "line-height":"40px", "background-color":"#888888", "border-radius":"40px", "text-align":"center", "margin-right":"12px"}); $("#expandable-weather-block .modal-body b").css("font-size", "18px"); $("#expandable-weather-block .modal-body li").css({"font-size":"14px", "line-height":"18px", "margin-bottom":"10px"}); $("#expandable-weather-block .modal-body ul").css({"margin-bottom":"24px"}); $("#expandable-weather-block .modal-body pre").css({"margin-bottom":"24px"}); $("#expandable-weather-block .modal-body img").css({"width":"100%", "margin-bottom":"20px", "borderWidth":"1px", "border-style":"solid", "border-color":"#aaaaaa"}); $("#expandable-weather-block .modal-body #mrd-alert"+ alertCount).css({"borderWidth":"0", "border-bottom-width":"1px", "border-style":"dashed", "border-color":"#aaaaaa", "padding-bottom":"10px", "margin-bottom":"40px"}); }); } function parseAlertJSON(json) { console.log(json); alertCount = 0; if (Object.keys(json.alerts).length > 0) { $("#mrd-wx-alerts .modal-body ").empty(); } $.each(json.alerts, function(key, val) { alertCount++; $("#mrd-wx-alerts .alert_count").text(alertCount); $("#mrd-wx-alerts .modal-body ").append(''); $("#mrd-wx-alerts .modal-body #mrd-alert"+ alertCount).append(""+val.title+""); // if (window.location.hostname == "www.kmov.com" || window.location.hostname == "www.kctv5.com" || window.location.hostname == "www.azfamily.com" || window.location.hostname == "www.kptv.com" || window.location.hostname == "www.fox5vegas.com" || window.location.hostname == "www.wfsb.com") { if (val.poly != "" && val.polyimg != "") { $("#mrd-wx-alerts .modal-body #mrd-alert"+ alertCount).append(''); } else if (val.fips != "" && val.fipsimg != "") { // $("#mrd-wx-alerts .modal-body #mrd-alert"+ alertCount).append(''); } // } //val.instr = val.instr.replace(/[W_]+/g," "); $("#mrd-wx-alerts .modal-body #mrd-alert"+ alertCount).append(val.dhtml+"

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What to expect on AREA15's Sept. 17 opening day in Las Vegas - FOX5 Las Vegas

Relay Therapeutics Announces Dosing of First Patient in First-in-Human Clinical Trial of RLY-4008, a Highly Selective FGFR2 Inhibitor | Small…

DetailsCategory: Small MoleculesPublished on Friday, 04 September 2020 11:09Hits: 94

CAMBRIDGE, MA, USA I September 03, 2020 I Relay Therapeutics, Inc. (Nasdaq: RLAY), a clinical-stage precision medicine company transforming the drug discovery process by leveraging unparalleled insights into protein motion, today announced the first patient has been dosed in a first-in-human clinical trial of RLY-4008 enriched for patients with intrahepatic cholangiocarcinoma (ICC) and other advanced solid tumors harboring a fibroblast growth factor receptor 2 (FGFR2) alteration. RLY-4008 is the only selective small molecule inhibitor of FGFR2 in clinical development.

We are excited to bring RLY-4008, our second targeted therapeutic, into clinical development, said Don Bergstrom, M.D., Ph.D., executive vice president of R&D of Relay Therapeutics. FGFR2 altered tumors are known to respond clinically to pan-FGFR inhibitors but with limited benefit to patients. RLY-4008 is an exquisitely selective and purpose-built medicine, discovered with our Dynamo platform, designed to dramatically alter the course of disease for patients with FGFR2 altered cancers.

The first-in-human trial is designed to evaluate the safety and tolerability of RLY-4008 in patients with advanced or metastatic solid tumors. The trial will predominantly enroll patients with molecularly identified FGFR2 fusions, mutations and amplifications during the dose escalation phase. Given RLY-4008s strong preclinical activity against both primary oncogenic alterations and acquired pan-FGFR inhibitor resistance mutations, the trial is enrolling patients who are nave to pan-FGFR inhibitors as well as those who have been exposed to prior therapy with pan-FGFR inhibitors. In the expansion part of the trial, five cohorts are planned to evaluate genetically defined populations: 1) ICC patients with a FGFR2 fusion previously treated with a pan-FGFR inhibitor; 2) ICC patients with a FGFR2 fusion not previously treated with a pan-FGFR inhibitor; 3) patients with an FGFR2 fusion and solid tumor other than ICC; 4) advanced, unresectable solid tumor patients with focal FGFR2 amplification; 5) advanced, unresectable solid tumor patients with an oncogenic FGFR2 mutation. Trial objectives include evaluating safety, tolerability, pharmacokinetics and anti-tumor efficacy. The trial is designed to enroll up to 125 patients.

About RLY-4008RLY-4008 is a potent, selective and oral small molecule inhibitor of FGFR2, a receptor tyrosine kinase that is frequently altered in certain cancers. FGFR2 is one of four members of the FGFR family, a set of closely related proteins with highly similar protein sequences and properties. Preclinically, RLY-4008 demonstrated FGFR2-dependent killing in cancer cell lines, while showing minimal inhibition of other targets, including other members of the FGFR family. RLY-4008 is currently being evaluated in a first-in-human trial designed to treat patients with advanced or metastatic FGFR2-altered solid tumors. To learn more about the first-in-human clinical trial of RLY-4008, please visit here.

About Relay TherapeuticsRelay Therapeutics (Nasdaq: RLAY) is a clinical-stage precision medicines company transforming the drug discovery process with the goal of bringing life-changing therapies to patients. Built on unparalleled insights into protein motion and how this dynamic behavior relates to protein function, Relay Therapeutics aims to effectively drug protein targets that have previously been intractable, with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology. The Companys Dynamo platform integrates an array of leading-edge experimental and computational approaches to provide a differentiated understanding of protein structure and motion to drug these targets. For more information, please visit http://www.relaytx.comor follow us on Twitter.

SOURCE: Relay Therapeutics

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Relay Therapeutics Announces Dosing of First Patient in First-in-Human Clinical Trial of RLY-4008, a Highly Selective FGFR2 Inhibitor | Small...

No pain, still gain (of function): the relation between sensory profiles and the presence or absence of self-reported pain in a large multicenter…

The pathophysiology of pain in neuropathy is complex and may be linked to sensory phenotypes. Quantitative sensory testing, a standardized method to evaluate sensory profiles in response to defined stimuli, assesses functional integrity of small and large nerve fiber afferents and central somatosensory pathways. It has revealed detailed insights into mechanisms of neuropathy, yet, it remains unclear if pain directly affects sensory profiles. The main objective of this study was to investigate sensory profiles in patients with various neuropathic conditions, including polyneuropathy, mononeuropathy, and lesions to the central nervous system, in relation to self-reported presence or absence of pain and pain sensitivity using the Pain Sensitivity Questionnaire.A total of 443 patients (332 painful and 111 painless) and 112 healthy participants were investigated. Overall, loss of sensation was equally prevalent in patients with and without spontaneous pain. Pain thresholds were equally lowered in both patient groups, demonstrating that hyperalgesia and allodynia is just as present in patients not reporting any pain. Remarkably, this was similar for dynamic mechanical allodynia. Hypoalgesia was more pronounced in painful polyneuropathy whereas hyperalgesia was more frequent in painful mononeuropathy (compared to painless conditions). Self-reported pain sensitivity was significantly higher in painful than in painless neuropathic conditions.Our results reveal the presence of hyperalgesia and allodynia in patients with central and peripheral lesions of the somatosensory system not reporting spontaneous pain. This shows that symptoms and signs of hypersensitivity may not necessarily coincide, and that painful and painless neuropathic conditions may mechanistically blend into one another.

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No pain, still gain (of function): the relation between sensory profiles and the presence or absence of self-reported pain in a large multicenter...

Use of plasma therapy shouldn’t be considered as standard of care for Covid-19, NIH disputes Trump endorsement – MEAWW

There isn't enough evidence to support the use of plasma therapy for treating hospitalized Covid-19 patients, a panel of experts from the National Institute of Health said. The statement comes days after the US Food and Drug Administration (FDA) announced an emergency approval of the treatment, despite a lack of data on its safety and efficacy.

"There are insufficient data to recommend either for or against the use of convalescent plasma for the treatment of Covid-19," the NIH panel said in a statement. This was because there was no data from experiments that are considered gold-standard for evaluating a treatment: well-controlled, adequately powered randomized clinical trials. Plasma is a yellow liquid portion of the blood that is rich in antibodies. The idea behind the treatment [convalescent plasma] is collecting plasma from survivors of the disease and administering it to the infected patients. It is a century-old practice that was used against the flu and measles in the past.

At a press conference on August 23, US President Donald Trump hailed the treatment, calling it safe and effective. FDA Commissioner Stephen Hahn told reporters that convalescent plasma could cut Covid-19 deaths by 35%. That claim, however, was found to be inaccurate.

Writing an open letter to Hahn, Eric Topol, the editor-in-chief of Medscape and a professor of molecular medicine at The Scripps Research Institute said: "We cannot entrust the health of 330 million Americans to a person who is subservient to President Trumps whims, unprecedented promotion of unproven therapies, outrageous lies, and political motivations". He added: You have two choices to do the right thing. We cannot and will not rest until you make that choice. Following the backlash, the FDA Commissioner has walked back on his claim.

I have been criticized for remarks I made Sunday night about the benefits of convalescent plasma. The criticism is entirely justified. What I should have said better is that the data show a relative risk reduction not an absolute risk reduction.

Hahn's claim comes from an unpublished study, which compared patients who received plasma with a high concentration of antibodies with those who were given a lower amount. The authors found no difference in 7-day survival overall. But the findings showed some benefits for people hooked to a ventilator: 11% of participants who received the treatment with high antibody levels died within 7 days, compared with 14% who were given lower levels.

Although the data suggest that plasma with high antibody may benefit patients who are not connected to a ventilator for breathing support, there is still uncertainty about the efficacy and safety of the treatment, the experts said of the unpublished study.

The current data suggest that adverse reactions to the plasma therapy were "infrequent". But, they add, the data on long-term risks and whether it could weaken a patient's immune response to a second infection is not clear. "Convalescent plasma should not be considered standard of care for the treatment of patients with Covid-19," they noted."Prospective, well-controlled, adequately powered randomized trials are needed to determine whether convalescent plasma is effective and safe for the treatment of Covid-19," they wrote. "Members of the public and health care providers are encouraged to participate in these prospective clinical trials."

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Use of plasma therapy shouldn't be considered as standard of care for Covid-19, NIH disputes Trump endorsement - MEAWW

Special Scientist, Biobank Information Management Systems job with UNIVERSITY OF CYPRUS | 223742 – Times Higher Education (THE)

Title: Special Scientist (BIMS and EDC operation officer)Number of positions: One (1)Category: Contract for 2 years, with potential for renewalPlace of employment: University of Cyprus, Nicosia

The Molecular Medicine Research Center of the University of Cyprus has one opening for a Special Scientist, funded by the research program: Biobanking and the Cyprus Human Genome Project (CY-Biobank), which is co-funded by the European Commission, the Republic of Cyprus and the University of Cyprus.

Responsibilities

Requirements

Terms of employment

The position will be for full-time employment with a 2-year contract, and potential for renewal. The gross monthly salary will be commensurate to qualifications and previous experience and ranges between 1500 and 3000. There is no provision for a 13th salary.

Submission of applications:

The application material should be sent electronically as one single pdf file to: biobank@ucy.ac.cy at the latest until September 18, 2020.

For more information the candidates may contact the Coordinator of the project, Prof. C. Deltas, Tel.: 22-892882 or Email: Deltas@ucy.ac.cy

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Special Scientist, Biobank Information Management Systems job with UNIVERSITY OF CYPRUS | 223742 - Times Higher Education (THE)

Sep 4 Getting real with CBD- a veterinary surgeon’s perspective – Jill Lopez

It was about the third week into Bastions recovery from his TPLO surgery, and he was already having a rough time. Bastion was a gregarious yellow Labrador who had injured his stifle about 25 days earlier. Fortunately, his family elected to have the stifle surgically reconstructed. Initially, he was recovering well from surgery, but one day in particular, he returned to the hospital because hed had a brief setback. He was limping far more severely than would be normally expected at that stage of recovery. The osteotomy from his surgery had not yet completely healed, and he was still in the middle of his prescribed five weeks of strict exercise restriction. His family was trying their best, but Bastion wasnt having it. He was too active at home, and his humans were growing frustrated. Theyd received anti-anxiety medications but werent giving them. Instead, his family had decided to give him CBD oil at home. When I asked why, the client responded, I found CBD oil at the local farmers market, and I figured it would work just as well.

Like Bastion, an increasing number of pets are receiving cannabidiol (CBD) supplements. The popularity of CBD continues to rise, and many clients are incorporating it into the medication protocol for their pets, either as an adjunct or an alternative treatment option. Perhaps the initial interest in the benefits of CBD can be traced back to 1998, or possibly earlier, when scientists at the National Institutes of Health discovered that CBD could protect cells from oxidative stress. These findings fueled interest in the human medical field and, in large part, that appeal has beentransmuted into veterinary medicine. The regard for this molecule has risen to such levels that in many homes, CBD is being used as the sole treatment option for a variety of medical conditions. Veterinarians are becoming more fluent in the fascinating pharmacology regarding the use of this phytocannabinoid. A recent survey indicated that most veterinarians (61.5%) felt comfortable discussing the use of CBD with their colleagues, but only 45.5% felt comfortable discussing this topic with clients.1Furthermore, veterinarians and clients in states with legalized recreational marijuana were more likely to talk about the use of CBD products to treat canine ailments than those in other states.2Lastly, CBD was most frequently discussed as a potential treatment for pain management, anxiety, and seizures.1At first glance, the use of CBD has tangential or limited relevance in the world of veterinary surgery. However, as one takes a closer look at the putativeand provenbenefits, it is clear that we are just scratching the surface of its therapeutic benefits.

Pain

Whether you perform surgery within a specialty discipline (oncology, orthopedics, neurology, soft tissue surgery, mixed animal, oral/dental, etc.), or surgery is only a small part of your general practice, every veterinarian endeavors to manage pain aggressively. The first choice for pain relief among many clinicians are the medications that have been more extensively studied, including but not limited to anti-inflammatories, gabapentinoids, opioids, local anesthetics, and other analgesics (acetaminophen, amantadine, Cerenia, etc.). These medications or a combination thereof have been prescribed to treat pain from orthopedic surgery, soft tissue surgery, intestinal surgery, and surgical neuropathic conditions, to name just a few. In the most basic schema, pain is divided into four categories: nociceptive pain (a response to damaged tissue), neuropathic pain (a response to directly-damaged sensory or spinal nerves), centralized pain (the result of pain signals being improperly amplified), and inflammatory pain.1

Cannabinoids may have a role to play inmediatingall four of these types of pain states. When tissue is damaged, histamine, serotonin, TNF-alpha, IL-1-beta, IL-6 andIl -17 6, and interleukin 17 are released.2Cannabinoids bind to the CB1 receptors and attenuate the pain signal by slowing down the release of those neurotransmitters.3This process can take place locally or in the central nervous system.3Cannabinoids have also been shown to inhibit the release of GABA, a well-known neurotransmitter associated with pain.3Although there is a paucity of clinical research on the use of CBD to treat postoperative pain in the veterinary medical setting, there has been heartening research conducted in humans. Indeed, the National Academies of Sciences, Engineering, and Medicine concluded that there is substantial evidence that cannabis is an effective treatment for chronic pain in adults.

Opioids have long been the go-to option or cornerstone of pain management, but the potential for the adverse events associated with the use of opioids in veterinary patients is universally accepted.38I have seen how distressing it can be for a family to see their pet experiencing any of the unpleasurable side effects of opioids, including urine retention, delayed bowel movements, whining, panting, disorientation, or other manifestations of dysphoria. Those are just some of the challenges that clinicians face when using opioids for chronic pain management. Considering the ongoing consequences of the opioid epidemic, there is a search for pain management solutions that are innovative, prone to less adverse events, and are more effective. As the scientific community begins to evaluate the evidence for use of CBD, it is clear that more research is needed.

Anecdotal reports of CBDs efficacy as a pain reliever are ubiquitous, but more practitioners are turning to scientific data for evidence of CBDs efficacy. A study in 2020 evaluating effects of CBD hemp extract on opioid use and quality-of-life indicators in chronic pain patients found that over half of chronic pain patients (53%) reduced or eliminated their opioids within eight weeks after adding CBD-rich hemp extract to their regimens.5Almost all CBD users (94%) reported quality-of-life improvements.5A recent study evaluating orally consumed cannabinoids for long-lasting relief of allodynia in a mouse model found that cannabinoids reduced hyperalgesia, and a similar effect was not found with morphine.4Mouse vocalizations were recorded throughout the experiment, and mice showed a large increase in ultrasonic, broadband clicks after sciatic nerve injury, which was reversed by THC, CBD, and morphine.4The study demonstrated that cannabinoids provide long-term relief of chronic pain states.4If research shows that use of cannabinoids in animalsspecifically, CBDcan help to decrease the use of opioids for pain management, that would help make more animals comfortable and potentially help to fight the tragic epidemic of human prescription opioid abuse. Further research is needed in a variety of species, specifically, both the canine and feline species.

Bone Healing

Both general veterinary practitioners and veterinary surgeons commonly diagnose and treat fractures. No large retrospective study of fracture incidence in dogs in North America has been published since 1994; however, the findings from that years study are still informative regarding the frequency of bone injuries. The study demonstrated that approximately 24% of all patients in the population studied over a 10-year period were affected by a disorder of the musculoskeletal system, with fractures contributing the largest proportion (over 29%) of all of the diagnoses of the appendicular skeletal system.7Although that research is dated, the conclusions from this study, at the very least, indicate that fractures are commonplace in the clinical veterinary setting.7Fracture repair has gradually become more straightforward due to improvements in technology. Because of these innovations, specialty surgeons and general practitioners who repair fractures have begun to see better surgical outcomes. So whether you primarily stabilize fractures with implants, or if external coaptation of fractures with the intention to refer (or perhaps as the primary means of fixation) is your treatment of choice, all veterinary practitioners aim to help fractured bones heal quickly. Despite these technological improvements, bone healing can be protracted or non-existent with some fractures. There are a variety of options at a veterinarians disposal to kick-start the healing process, but perhaps in the near future, CBD may be added to thatarmamentarium[AC3]. The effect of CBD in fracture healing has been investigated evaluating bone callus formation in femur fractures in a rat model.8The findings demonstrated enhanced biomechanical properties of healing fractures in those given CBD compared with a control group.8This effect was not found in those given only 9-THC. Moreover, the bone-forming (osteogenic) effects of CBD were weakened when test subjects were given equal amounts of CBD and 9-THC.6Another in vivo research study indicated that when CBD is incorporated into a surface that promotes bone growth (osteoconductive scaffold) it can stimulate stem cell migration and osteogenic differentiation.9Further studies are needed to better evaluate the role of CBD in healing and bone metabolism of companion animals so that these findings can be applied in the clinical setting.

Additionally, cannabis has been shown to be a useful addition in treatment plans to improve bone health in laboratory studies. Studies have endeavored to better understand the role of CB2 receptors in maintaining bone health. CB2 receptors in bone cells have been linked to maintaining bone density and stimulating growth and may therefore have a part in reversing the effects of osteoporosis.10One study evaluating the role of CB2 receptors found that mice whose genes had been altered to remove the CB1 or CB2 receptors developed signs of bone weakness that were far more pronounced than those in the control group.12Another study in 2009 investigated the relationship between CB2 expression and bone disease in humans. It found that people with dysfunctional CB2 receptors have significantly weaker hand bones.11

Arthritis

Osteoarthritis (OA) affects many dogs, large and small. Most often, OA is the consequence of a developmental orthopedic disease that affects a single joint or a pair of joints and, less often, affects multiple joints. It is axiomatic that Mother Nature likes symmetry, thus developmental orthopedic diseases frequently affect both left and right joints. For example, hip dysplasia is reportedly bilateral in >60% of affected dogs,13and elbow dysplasia is bilateral in approximately 50% of affected dogs.14Osteoarthritis occurs secondary to a myriad of primary orthopedic conditions that affect a variety of joints including: the hip (most common causes of OA in the hip: hip dysplasia, Perthes disease); stifle (patellar luxation, cranial cruciate ligament disease, osteochondritis dissecans [OCD]); elbow (elbow dysplasia, elbow OCD, fragmentation of the medial coronoid process, incomplete ossification of the humeral condyle); shoulder (shoulder OCD, developmental shoulder subluxation); tarsus (OCD of the talus), and carpus (carpal laxity, carpal subluxation secondary to chondrodystrophy); andmetacarpophalangeal (MCP) and metatarsophalangeal (MTP) jointdegenerative osteoarthritis (digital osteoarthritis).

Cannabinoids were found to treat pain secondary to inflammation in a variety of studies on humans. Some of the most compelling research has shown that cannabis can reduce the inflammation in the joint caused in human patients diagnosed with immune-mediated arthritis.15One study found that cannabinoids could simultaneously reduce the secretion of cytokines involved in inflammation from one type of TH immune cells, which were being under-produced, while also increasing their numbers to correct their scarcity.15Furthermore, in a study in 2003, researchers found that plant-based cannabinoids could suppress the expression of interleukin-1betaone of the most prominent markers for inflammation in patients with rheumatoid arthritisby as much as 50%.16And finally, in 2006, transdermal applications of CBD were shown to decrease biomarkers that can contribute to neurogenic inflammation in a sample of arthritic rats.17

A report published inThe Journal of PAINand written by researchers at Baylor College of Medicine revealed the results of a large, double-blinded, placebo-controlled study on the positive effects CBD had in the fight against osteoarthritis.18The study was designed with two main goals: The first portion of the research studied the effect CBD had on the inflammatory molecules and cells in mice.18The second portion of the study investigated whether CBD improved the quality of life in dogs diagnosed with osteoarthritis. In lab tests and in mouse models, CBD significantly decreased the production of natural chemicals that promote inflammation, and it increased the natural chemicals that fight inflammation.18Essentially, they saw a drop in proinflammatory cytokines and an increase in anti-inflammatory cytokines.18For dogs with osteoarthritis, CBD significantly decreased pain and increased mobility in a dose-dependent fashion. Importantly, a lower dose of liposomal CBD was as effective as the highest dose of non-liposomal CBD, indicating that the effect of CBD was quicker andmore powerful when CBD was delivered encapsulated in liposomes than without.18Blood samples indicated no significant harmful side effects or adverse events over the 4-week analysis period.18Although this study is very promising, and it supports the safety and therapeutic potential of hemp-derived CBD for relieving arthritic pain in dogs, it is important to consult with your pets veterinarian before giving any supplement or medication.

In the veterinary population, use of cannabidiol and other alternative treatments has the potential to obviate the need for other medications and thus spare patients from adverse effects associated with their use. More likely, the use of cannabinoids could be additive or synergistic in a multimodal treatment strategy and could increase quality-of-life issues associated with painful arthritic conditions.

Intervertebral Disk Disease

As our patients age, discs in their spines undergo degenerative changes. Thus, degeneration of intervertebral discs is inevitable. This process of degeneration is multifactorial, and it involves hypoxia, inflammation, neoinnervation, accelerated catabolism, and reduction in water and glycosaminoglycan content.39The magnitude and severity of disc degeneration can vary widely between patients. The most common locations of clinically relevant disc disease are the cervical spine, thoracolumbar spine, and lumbosacral spine.40Although there are various manifestations of disc disease, broad classifications of Hansen Type I and Type II are typically used to describe the condition. In short, disc material may either extrude (acute herniations) or protrude (chronic herniations), both of which compress the spinal cord, which can ultimately cause pain, paresis, paralysis, and other neurological deficits.40Theprevalence of thoracolumbar disc disease in dogs has been estimated at 3.5%.40Depending on the neurologic examination, diagnosis, severity, prognosis, and other factors, surgery may be recommended to decompress the spinal cord. After surgical decompression,there is a hostof challenges that the patient, the family, and the surgeon may have to work through, including a potentially protracted recovery, recurrence of neurological signs, post-surgical pain, spinal instability, urinary disorders, (cystitis, urinary tract infection, urinary retention, micturition disorders), ascending myelomalacia, and others.41Could CBD play a part in helping to improve those affected by disc disease pre-, intra-, or post-operatively, and what types of spinal disorders could benefit from CBD? A study conducted on the use of CBD in mice with degenerative disc disease showed promise in mitigating the effect of disc damage and wear.19Instead of being ingested orally, CBD was injected at the site of the disc. Researchers investigatedthe effects of cannabidiol intradiscal injection using a combination of MRI and histological analyses.19A puncture was created in the disc, and then CBD was injected into the disc (30, 60 or 120 nmol) shortly after.19The effects of intradiscal injection of cannabidiol were analyzed within 2 days by MRI.17Fifteen days later, the group that received cannabidiol 120 nmol was resubmitted to MRI examination and then to histological analyses after the cannabidiol injection.19They found that cannabidiol significantly decreased the effects of disc injury induced by the needle puncture.19These results suggest that this compound could be useful in the treatment of intervertebral disc degeneration, perhaps using a novel route of administration. Unfortunately, the exact mechanism for howCBD oil helped alleviate disc damage is still being investigated. The hope is that theneuroprotective properties of cannabidiol can also be found in the study of canine and feline disc disease to ultimately improve functional recovery.

Neuropathic Pain

Fortunately, more effort, research, and attention is being paid to treating pain in veterinary medicine.Nociceptive pain is caused by external pressure, cold, heat, or internal trauma, stimulated by the release of compounds like bradykinin, prostaglandins, or leukotrienes.20Humans may describe this pain as a sharp, aching, or throbbing sensation. In veterinary patients, nociceptive pain may be manifested by limping, sharp movements, lip smacking, panting, vocalization, or, in select cases, no obvious response. The function of nociceptive pain in humans, and presumably in pets, is to alert them that they are injured and hopefully prevent further injury.20

Neuropathic pain, caused by direct damage to sensory or spinal nerves, allows aberrant pain signals to be sent to the brain.21In veterinary patients, a common example of neuropathic pain that I diagnose commonly is sciatic or radial nerve hyperpathia, but lumbar or cervical foraminal radiculopathies can also be relatively frequent causes of neuropathic pain. Neuropathic pain syndromes are often secondary to intervertebral disc disease, static and dynamic nerve foramen impingement, vertebral instability, recent surgery, trauma, abnormal conformation, abnormal gait, and chronic joint pain.21A classic example of neuropathic pain in humans is diabetic neuropathy.

Unfortunately, there are some challenges to diagnosing and understanding neuropathic pain in the veterinary setting, particularly in the presence of an otherwise normal orthopedic exam. To be sure, neuropathic pain can be evoked by low- or high-intensity stimuli; it can be spontaneous and not stimulus-dependent; it is maladaptive (maintained in the absence of tissue trauma), and it responds poorly to opiates and anti-inflammatory drugs.21

CBD use has shown promise in the treatment of neuropathic pain. In a 2010 study, researchers looked at a sample of diabetic rats and administered daily doses of Cannabis sativa ranging from 25 to 100mg/kg[AC6]of body weight.22After fourteen days, the rats exhibited significant reductions in tingling, heat, and pain in the extremities associated with advanced diabetes.22Another study, from 2015, compared descriptions of spontaneous pain among sixteen patients with painful diabetic peripheral neuropathy in a randomized, double-blinded setting.23The study subjects were administered four single-dosing sessions of placebo or cannabis. Significant reduction in pain intensity varied directly with the size of their dose.23

As we begin to understand neuropathic pain in animals more clearly, treatment strategies and pharmaceutical alternatives will more adequately address their pain, possibly including the use of CBD or CBD alternatives. Additional research will hopefully actualize the promise and potential that CBD may have in treating the veterinary population in neuropathic pain.

Anxiety

Exercise restriction is a critical component for successful surgical outcomes in many elective orthopedic surgeries. For example, post dynamic stifle stabilization surgery, I frequently recommend a minimum of five to eight weeks of strict monitoring and exercise restriction. This recommendation can be extremely challenging for families, because many of the animals are inclined to be active, are frequently powerful and athletic, and are young and unaccustomed to confinement. Implant failure or a poor surgical outcome overall can many times be ascribed to the challenges related to activity restriction. Difficulties with this process may lead to protracted recovery or even surgical treatment failure, necessitating a second surgical procedure.

Common pharmaceutical strategies employed to help with exercise restriction include the use of Trazodone and Acepromazine.24However, both of these medications can have variable effects depending on the individual, and in some cases, there are undesirable adverse effects (e.g. excessive sedation and paradoxical excitation with Acepromazine,serotonin syndrome with Trazodone, etc.).24

Could CBD or CBD derivatives enhance calmness and alleviate anxiety in animals? Based on CBDs proposed mechanism of action in mitigating anxiety, the answer may be encouraging. Higher levels of natural endocannabinoids in the human body are associated with an antidepressant effect.25Cannabinoid receptors are found throughout the central nervous system and play a key part in maintaining our sense of well-being. They are particularly numerous in cells tasked with manufacturing serotonin where it is needed.25

Cannabidiol may also have an effect on the hippocampus, which is a region of the brain responsible for memory and mood. Glucocorticoids are secreted during stress, which may cause the hippocampus to atrophy.26That shrinking process plays a role in diminished memory and depressed mood.26Cannabinoids have shown an ability to counter this process through the phenomenon ofhippocampal neurogenesis(regrowth and development in nerve tissue), which can be activated by the expression of cannabinoid type-1 receptors.26Both natural endocannabinoids and plant-based cannabinoids have both been shown to accelerate this process.26

In another random-controlled trial performed on humans, subjects receiving a 600 mg CBD supplement also reported less subjective anxiety symptoms during public speaking than those whod taken a placebo.27CBD also shows activity specific to the limbic system in the brain. A study evaluating that effect on the limbic system found that CBD administration helped to reduce symptoms in people with social anxiety disorder.28Indeed, the National Academies of Sciences, Engineering, and Medicine specifically referenced CBDs effects in a statement about anxiety disorders, there is evidence that cannabidiol is an effective treatment for the improvement of anxiety symptoms, as assessed by a public speaking test in individuals with social anxiety disorders.30

A 2019 study in mice simulated to have an anxiety disorder, (Fragile X Syndromea neurodevelopmental disorder that affects intellectual, social, and physical development due to a mutation of the FMR1 gene) were shown to have fewer anxiety-related behaviors across tests when given CBD.31Furthermore, CBD decreased the anxiety response of all mice tested while not affecting their cognitive performance.31

The potential for CBD to be efficacious in treating anxiety in other species will be important to study, but its use as an anxiolytic and sedative is growing in popularity despite the paucity of research specific to this indication. As previously mentioned, anxiety was one of the most common reasons for veterinarians to discuss CBD.1The most commonly used CBD formulations were oil/extract and edibles1for the putative benefits of relieving anxiety, among others.1As CBD research continues to gain steam, more attention will hopefully be directed towards how the full ensemble of cannabinoids, terpenes, and flavonoids seem to complement each other, working through multiple receptors at once, and often enhancing each others signals to the body (entourage effect).

Wound Healing

When it comes to wounds, all medical professionals are generally united in a common purpose: we want wounds to heal faster. Indeed, products that promote or accelerate wound healing have been of interest to veterinarians and physicians since the advent of wound treatment. Wound healing products and topical agents may target different phases of wound healing, including debridement, wound contraction, epithelialization, and granulation. Many products promote the formation of granulation tissue, while others are more effective after granulation tissue has formed (e.g. hyaluronic acid). For this reason, adapting the topical dressing specific to the stage and progress of wound healing is of utmost importance.

CBD has shown efficacy in the maturation phase of wound healing and some inflammatory skin conditions.33In a 2019 study of 20 patients with two most frequent skin disorderspsoriasis (5 patients), atopic dermatitis (5), and resulting outcome scars (10)the subjects were instructed to administer topical CBD-enriched ointment to lesioned skin areas twice daily for three months.33The results showed that topical treatment with CBD-enriched ointment significantly improved the skin parameters and the symptoms associated with the skin condition.33This study concluded that the topical administration of CBD ointment, without any THC, is a safe, effective, and non-invasive alternative for improving the quality of life in patients with some skin disorders, especially inflammatory ones.33Another study in 2019 investigated the potential effect of a Cannabis sativa L. ethanolic extract standardized in cannabidiol as anti-inflammatory agent in the skin.34The study found that the extract inhibited the release of mediators of inflammation involved in wound healing and inflammatory processes occurring in the skin.34The down-regulation of genes involved in wound healing and skin inflammation was at least in part due to the presence of cannabidiol.34The findings provided new insights into the potential effect of Cannabis extracts against inflammation-based skin diseases.

Bacterial infiltration can negatively influence wound healing. Another area in which topical cannabis treatments show a great deal of potential is in the treatment of bacteria-related skin disorders. One study from 1976 indicated that isolates of THC and CBD were effective in reducing samples of staphylococci and streptococci, two bacteria associated with acne.35Another study from 2008 found that the plant-based CBD, CBC, CBG, THC, and CBN were substantially potent against a variety of Staphylococcus aureus strains, which were resistant to the antibiotic methicillin (MRSA).36

However, a recent study perhaps underscores the importance of adjusting topical therapy according to the stage of healing. In 2020, theAustralian Veterinary Journalreported a study on horses with wounds that were created in a laboratory setting and then deliberately contaminated. Each wound was assigned to a treatment group that contained 1% cannabidiol in three different manuka honey formulations.37Treatments were applied topically daily for a total of 42 days. The results indicated that irrespective of the treatment, wounds did not retract as expected in the first seven days after wound creation.37There was no difference in wound area, daily healing rate, or days to complete healing between treatment groups.37This study highlights the importance for continued study on the correct time, concentration, and best practices when using CBD to accelerate wound healing.

Conclusion

Though the overall potential for cannabidiol to address specific surgical conditions is encouraging, strong double-blinded, placebo-controlled studies with large sample sizes are lacking. Based on the research thats available in animal models and among human patients, there are large pockets of convincing research that inspire hope and promise in the use of CBD in veterinary surgery and veterinary medicine writ large. To be sure, the concept of scientific integrative medicine should be considered along with other first-line treatments for veterinary patients. Evidence-based solutions should be prioritized when treating disease, but innovative or novel treatments may have to be considered in patients with neuropathic pain, disc disease, anxiety, or debilitating arthritis.New discoveries in the world of cannabis-based medicine may be just what the doctor ordered for an effervescentLabrador like Bastion.

References:

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Capano, A., Weaver, R., Burkman, E. (2020) Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study.Postgraduate Medical Journal.132(1):56-61. DOI:10.1080/00325481.2019.1685298. Epub 2019 Nov 12.

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Kogan, N.M., Melamed, E., Wasserman, E. (2015) Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts.Journal of Bone and Mineral Research, 30(10):1905-13. DOI: 10.1002/jbmr.2513. Epub 2015 May 10.

Kamali, A., Oryan, A., Hosseini, S., Ghanian, M. H., Alizadeh, M., Baghaban Eslaminejad, M., & Baharvand, H. (2019) Cannabidiol-loaded microspheres incorporated into osteoconductive scaffold enhance mesenchymal stem cell recruitment and regeneration of critical-sized bone defects.Materials Science and Engineering, 101, 6475. DOI:10.1016/j.msec.2019.03.070

Bab, I., Zimmer, A. (2007) Cannabinoid Receptors and the Regulation of Bone Mass.British Journal of Pharmacology, 153:182-188. DOI:10.1038/sj.bjp.0707593

Idris, A.I. (2010) Cannabinoid Receptors as Target for Treatment of Osteoporosis: A Tale of Two Therapies.Current Neuropharmacology,8(3), 243253.DOI:10.2174/157015910792246173

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Silveira, J.W., Issy, A.C., Castania, V.A., Salmon, C.E.G., Nogueira-Barbosa, M. H., et al. (2014) Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration.PLOS One, 9:12. DOI:10.1371/journal.pone.0113161

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Serra, G. & Fratta, W. (2007) A possible role for the endocannabinoid system in the neurobiology of depression.Clinical Practice and Epidemiology in Mental Health, 3(1), 25. DOI:10.1186/1745-0179-3-25

Kim, E. J., Pellman, B., & Kim, J.J. (2015) Stress effects on the hippocampus: a critical review.Learning & Memory, 22(9), 411416. DOI:10.1101/lm.037291.114

Demirakca, T., Sartorius, A., Ende, G., et al. (2010) Diminished gray matter in the hippocampus of cannabis users: Possible protective effects of cannabidiol.Drug and Alcohol Dependence. DOI:10.1016/j.drugalcdep.2010.09.020

Bergamaschi, M.M., et al. (2011) Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Nave Social Phobia Patients.Neuropsychopharmacology, 36(6):1219-26 DOI:10.1038/npp.2011.6.

Crippa, J.A.S., et al. (2010) Neural Basis of Anxiolytic Effects of Cannabidiol (CBD) in Generalized Social Anxiety Disorder: A Preliminary Report.Journal of Psychopharmacology, 25:1 DOI:10.1177/0269881110379283.

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Zieba, J., Sinclair, D., Sebree, T., Bonn-Miller, M. (2019) Cannabidiol (CBD) reduces anxiety-related behavior in mice via an FMRP1-independent mechanism.Pharmacology Biochemistry and Behavior. DOI:10.1016/j.pbb.2019.05.002

Pamplona, F.A., da Silva, L.R., & Coan, A.C. (2018) Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis.Frontiers in Neurology, 9. DOI:10.3389/fneur.2018.00759

Palmieri, B., Laurino, C., Vadal, M. (2019) A therapeutic effect of CBD-enriched ointment in inflammatory skin diseases and cutaneous scars.La Clinica Terapeutica, Mar-Apr, 170(2):e93-e99. DOI: 10.7417/CT.2019.2116.

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Van Klingeren, B. & Ten Ham, M. (1976) Antibacterial Activity of 9-tetrahydrocannabinol and Cannabidiol.Antonie Van Leeuwenhoek, 42(1-2): 9-12. DOI:10.1007/bf00399444.

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McIver, V., Tsang, A., Symonds, N., Perkins, N., et al. (2020) Effects of topical treatment of cannabidiol extract in a unique manuka factor 5 manuka honey carrier on second intention wound healing on equine distal limb wounds: a preliminary study.Australian Veterinary Journal. DOI:10.1111/avj.12932

White, D.M., Mair, A.R., & Martinez-Taboada, F. (2017) Opioid-free anaesthesia in three dogs.Open Veterinary Journal, 7(2), 104. DOI:10.4314/ovj.v7i2.5

Hansen, T., Smolders, L.A., Tryfonidou, M.A., et al. (2017) The Myth of Fibroid Degeneration in the Canine Intervertebral Disc: A Histopathological Comparison of Intervertebral Disc Degeneration in Chondrodystrophic and Nonchondrodystrophic Dogs.Veterinary Pathology, 54 (6): 945-952.

Jeffery, N.D., Levine, J.M., Olby, N.J., et al. (2013)Intervertebral disk degeneration in dogs: consequences, diagnosis, treatment, and future directions. Journal of Veterinary Internal Medicine, 27 (6):1318-33.

Balducci, F., Canal, S., Contiero, B., et al. (2017)Prevalence and Risk Factors for Presumptive Ascending/Descending Myelomalacia in Dogs after Thoracolumbar Intervertebral Disk Herniation. Journal of Veterinary Internal Medicine,31 (2):498-504.

Go here to read the rest:

Sep 4 Getting real with CBD- a veterinary surgeon's perspective - Jill Lopez

What’s Happening Week of Sept. 6 | News | thealmanac.net – The Almanac

Seafood dinner

Elks Lodge 2213 will host a seafood dinner from 5 to 8 p.m. Sept. 11 at 2789 South Park Road, Bethel Park.

The event is eat-in or takeout. Menu items are: fish dinner with french fries, coleslaw, rolls and butter, $14.95; shrimp dinner with french fries, coleslaw, rolls and butter, $18.95, fish sandwich, $9.95; and clam chowder, $3.75.

Orders are in advance only by calling 412-831-0616.

Divorce workshop

A three-hour virtual divorce workshop will provide education and information on the legal, financial and emotional issues associated with divorce.

The workshop will be held via videoconference from 8:30 to 11:30 a.m. Sept. 12. Cost is $15 per person, and pre-registration is required by Sept. 9 to Donna at 724-493-9695.

Yoga in the Park

A Yoga in the Park program is scheduled for 9 to 10 a.m. Sept. 12 in the amphitheater at Peterswood Park, Peters Township.

No yoga experience is necessary. The certified instructor is Carrie Knight.

Items needed are a yoga mat and towel to protect the mat from the amphitheater stage floor. Wearing several layers of comfortable clothing is recommended, as is bringing water.

Social distancing and the use of masks are encouraged.

The fee is $12 for Peters Township Parks and Recreation members and $18 for nonmembers.

Online registration at http://www.peterstownship.com is preferred, but can also be done in person at the

Peters Township Community Recreation Center, 700 Meredith Drive. For more information, call 724-942-5000.

Barbecue dinner

Because of the continued limitations caused by the COVID pandemic, the Bethel Park Lions Club has decided to replace the scheduled fall fish fry with a drive-through barbecue event from 4 to 7 p.m. Sept. 18 at Lions Park on Irishtown Road.

The meal will include 1/4 chicken, ribs, baked beans, coleslaw, cornbread and a drink for $14. A childrens meal of a hot dog, coleslaw, chips and a drink will be available for $5.

There will be no advance ticket sales. Food will be served until it runs out, so diners are advised to attend early.

For more information, call Nancy at 412-760-5871.

Farmers market extended

The Bethel Park Recreation Farmers Market is being extended for two weeks, until Oct. 13.

The market is held from 3 to 7 p.m. Tuesdays in the VIP parking lot in South Park, off Corrigan Drive. For more information, visit http://www.bethelparkfarmersmarket.com/.

Recycling review

A program on recycling regulations and their changes over the years is scheduled from 5 to 6 p.m. Sept. 14 in the community room at the Peters Township Community Recreation Center.

Social distancing will be practiced. Masks mandatory to enter the building.

The fee is $5 for members and $8 for nonmembers. Group size is limited to 12 participants ages 18 and older.

Registration deadline is Sept. 11 at http://www.peterstownship.com. For more information, call 724-942-5000.

COVID-19 virtual town hall

Medical experts from St. Clair Hospital and Mayo Clinic are hosting a free virtual town hall on Zoom to answer the communitys questions on the COVID-19 pandemic from 6:30 to 7:30 p.m. Sept. 30.

The event is being moderated by Dr. Maria Simbra and will feature St. Clair physicians Stephen Colodny, chief of infectious disease; John Sullivan, senior vice president and chief medical officer; and Ruth Christoforetti, family medicine and primary care. Also joining are Mayo Clinic physicians Stacey Rizza, executive medical director for international academic affairs and Andrew Badley, professor of medicine and molecular medicine.

The virtual town hall coincides with St. Clairs fourth anniversary as a member of the Mayo Clinic Care Network. For more information, including how to participate in the town hall, visit stclair.org.

Fairview Fall Virtual 5K

In lieu of South Fayette Community Day and other large in-person events this year, South Fayette Township and Dollar Bank are partnering to present a new community event, the Fairview Fall Virtual 5K and Family Fun Run.

Adults and children are invited to run or walk during event week, Sept. 26 through Oct. 2, to raise money toward building an Americans With Disabilities Act-accessible playground in Fairview Park.

Registration is $25 per person or $60 per family. The fee includes free T-shirts and other items, raffles and race prizes.

Everyone is welcome to participate as individuals, households or larger fundraising groups. Participants can run anywhere, at any time, during race week, and tune into Facebook @SouthFayetteTownship during event week for live videos and drawings.

For details and registration, visit https://runsignup.com/southfayette. Additional virtual and at-home activities are listed at https://southfayettepa.com/recathome.

For questions about the event, contact Paula Willis, South Fayette Township parks and recreation director, at pwillis@sftwp.com or 412-221-8700, extension 217.

Original post:

What's Happening Week of Sept. 6 | News | thealmanac.net - The Almanac

Illumina Collaborates With 54gene in the Creation of a World-Class Genomics Facility in Nigeria – Business Wire

CAMBRIDGE, England--(BUSINESS WIRE)--Illumina, Inc. (NASDAQ: ILMN) today announced a collaboration with 54gene, a health technology company whose mission is to advance precision medicine capabilities in Africa through research, advanced molecular diagnostics and clinical programs. The partnership will support the establishment of a new genetics facility in Lagos, Nigeria, equipped with a suite of Illumina's cutting-edge sequencing and high-density microarray technology platforms, which will generate genetic information for health research and drug development.

Africa contains more genetic diversity than any other continent because the African genome is the oldest human genome. Yet it is estimated that fewer than 3% of the genomes analyzed come from Africans, making it a potentially rich source of new genetic information for health and drug discovery research, which 54gene intends to leverage as a global research resource while ensuring Africans benefit from cutting-edge medical innovations.

Paula Dowdy, SVP, General Manager EMEA, Illumina, said, Its incredibly important to ensure equitable access to genomic sequencing technology across the world so that genomes can be interpreted in the context of global diversity. Through partnerships such as this with 54gene, we aim to remove barriers of access to sequencing and expand the benefits of genomics to as many people as possible.

54gene Founder and CEO Dr. Abasi Ene-Obong said, The addition of Illuminas cutting-edge technology to our research and diagnostic capabilities is a critical step for 54gene in fulfilling our mission of equalizing access to precision medicine. This is part of our wider commitment to build capacity and infrastructure in Africa, which will allow us to significantly expand genomics research, while also improving health outcomes on the continent. Alongside our many partners in the African medical and scientific community, we want to make advanced molecular diagnostics more accessible to the region, while creating hundreds of skilled jobs in molecular biology and bioinformatics.

Through the partnership, African samples stored in 54genes de-identified biobank, will be genotyped, sequenced and analyzed without the need to send samples overseas, reflecting Illuminas commitment to enabling Africa to expand its genomic capabilities. Having local infrastructure will reduce costs and turnaround time for test results. Illumina will also deliver its renowned training to support the use of its sequencing and microarray equipment and ensure ongoing support for 54genes growing team of molecular scientists.

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To learn more, visit the Illumina News Center.

About Illumina

Illumina is improving human health by unlocking the power of the genome. Our focus on innovation has established us as the global leader in DNA sequencing and array-based technologies, serving customers in the research, clinical and applied markets. Our products are used for applications in the life sciences, oncology, reproductive health, agriculture and other emerging segments. To learn more, visit http://www.illumina.com and connect with us on Twitter, Facebook, LinkedIn, Instagram, and YouTube.

About 54gene

54gene is a health technology company advancing the state of healthcare through large-scale discovery and translational research, advanced molecular diagnostics, and inclusive clinical programs for the benefit of Africans and the global population. Founded in 2019, 54gene utilizes human genetic data derived from diverse African populations, to improve the development, availability, and efficacy of medical products and diagnostics that will prove beneficial to Africans and the wider global population.

Use of forward-looking statements

This release contains forward-looking statements that involve risks and uncertainties. These forward-looking statements are based on our expectations as of the date of this release and may differ materially from actual future events or results. Among the important factors that could cause actual results to differ materially from those in any forward-looking statements are our ability to expand the adoption and use of genomics, especially in clinical settings, together with other factors detailed in our filings with the Securities and Exchange Commission, including our most recent filings on Forms 10-K and 10-Q, or in information disclosed in public conference calls, the date and time of which are released beforehand. We undertake no obligation, and do not intend, to update these forward-looking statements, to review or confirm analysts expectations, or to provide interim reports or updates on the progress of the current quarter.

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Illumina Collaborates With 54gene in the Creation of a World-Class Genomics Facility in Nigeria - Business Wire