Dr. Pennell on the Evolution of Targeting HER2 in Lung Cancer – OncLive

Nathan A. Pennell, MD, PhD, discusses the evolution of targeting HER2 in lung cancer.

Nathan A. Pennell, MD, PhD,an associate professor in theDepartment of Medicine and director of the Lung Cancer Medical Oncology Program at theTaussig Cancer Institute of Cleveland Clinic,discusses the evolution of targeting HER2 in lung cancer.

HER2 is a target that has been around for a long time because it is used routinely in the treatment of patients with breast cancer, says Pennell. In lung cancer, it has beenrecognizedthatHER2mutations in the HER2 tyrosine kinase domain have been present in the disease for a long time; roughly2% of lung adenocarcinomas haveHER2mutations, adds Pennell.

Unfortunately, thecurrent data on targeting HER2 haveproven to bedisappointing, according to Pennell. TKIs that target EGFR and HER2, such as afatinib (Gilotrif), have had trials,but have demonstrated relatively marginal efficacy and an effect that is short lived. However, that seems to have changed recently with the emergence of the antibody-drug conjugates (ADCs).

ADCs have shown demonstrated promising efficacy in phase 2 trials withHER2-mutant lung cancer. Over the past few years,sometrials examining these agents in lung cancer have been presented at medical meetings.For example, findings froma phase 2 trialwithado-trastuzumab emtansine (Kadcyla; T-DM1) were reported,and this agent is already available for useinHER2-positive breast cancer.The agentwas examinedina cohort of patients withHER2-mutant lung cancerandwas found to elicit an impressive overall response rate of44%with a promising duration of control, says Pennell. This agent was probably used off label for HER2-positive lung cancer after these data were presented, Pennell adds.

Then, an oral presentation was delivered during the2020 ASCO Virtual Scientific Meetingon the phase 2 DESTINY-Lung01trial, which evaluated the ADC fam-trastuzumab deruxtecan-nxki (Enhertu) inHER2-mutated lung cancer. The agent showed an impressive response rate of 61.9%, which is comparable with what is expectedwith otherEGFR inhibitors inEGFR-mutant lung cancer.Trastuzumab deruxtecan also hadan estimated progression-free survival of 14 months. For the first time,the field is starting to see targeted drugs for this patient population that mirror targeted drugs that have been developed for other molecular alterations in lung cancer, concludes Pennell.

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Dr. Pennell on the Evolution of Targeting HER2 in Lung Cancer - OncLive

Teachers Day 2020: An Evolution in the teaching techniques and opportunity for the personal growth of the teachers – The Financial Express

By Rajeev Tiwari and Anurag Gupta

COVID19 has unexpectedly led to a tough time for People, Companies, Businesses across the globe. But it is just another test of the strong resoluteness and unwavering attitude of human beings of not losing the hope even in the most adverse times, and a testimonial to the firm desire in our quest to find a tangible working solution in the most adverse conditions. If simply put, it is an eye opener for the world to see how mankind can stay strong even during the worst of times and walk towards the path of light when all they can find is darkness.

COVID19 has proven once again that the Teacher Community can fight all odds so as to deliver the best in class teaching methodology to their beloved students. They are willing to walk that extra mile to ensure that their students dont suffer a loss even during a situation which has led half the world into trauma. So first of all, a Grand Salute to every Teacher in the World.

In India, around March-April 2020 every student, parents were worried that how the education of the students will proceed in these tough times, but the Teaching community was very quick to adopt a blend of Digital Technologies and give it a personalized touch so as to deliver the best in class education to the students. They made sure they adapted all the necessary strategies and techniques which would not only be helpful for the students but also be a method that can be followed even when things turn normal. Teaching online is one of the techniques, that not every teacher was accustomed with, but learned during the pandemic only to provide the best of education to their students.

In these tough times, Digital Technologies that have proved very useful-

1. Conducting Online Classes via Zoom, MS Team, Google Meet

2. Online Virtual Class environment Lot of companies in EdTech space like Google Class, ClomoLMS, etc have come with Integrated Solution to offer End to Solution Covering Attendance Tracking, Lessons, Assignment, Quizzes, Gradebook and offering End to Online Class Delivery along with tracking students progress like in a normal offline mode.

3. Conducting Webinar and Tech Capsules Online to students, teachers so as to give an exposure to new trends to the stakeholders via an Interactive Webinar and Panel Discussions.

All these offer a great opportunity to teachers for their own personal growth and a new learning path that extends a possibility of adopting the best of Digital Technologies for Education Delivery, Using AI and Analytics to track down the growth of the students and offer a data based Career Progression Path and at the same time integrating it with apersonal touch, ethos, compassion, wisdom and ethics of a great Teacher.

(The authors are Founder at STEMROBO and Tinker Coders, Views expressed are their own.)

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Teachers Day 2020: An Evolution in the teaching techniques and opportunity for the personal growth of the teachers - The Financial Express

‘A villain of the times’: The evolution of Zozobra – KOAT New Mexico

Old Man Gloom is 96 years old and he still looks great. But he never looks the same. Each year he grows taller, wears new clothes or has a different hair style. The evolution of Old Man Gloom is ever changing.Hes one of the most notorious characters in New Mexico. You can call him a chameleon of the times. I feel in love with the guy. I would say he was my first boyfriend, said Zozobra Deputy Event Chair Judith Moir.Black and white photos show Zozobra in the early years and key points in our history. As the years go on, Old Man Gloom becomes the monsters we need him to be. He becomes the villain of America. All the planning and design for Zozobra is done around the decade of his history, said Moir.In 1982, the marionette has buttons along his top and a black belt. Then two years later, in 1984, he ditched some of his buttons for a bow tie, which would become his iconic look in the years to come. Then in 1985 and 1986, Old Man Gloom had orange hair.Then the '90s Zozobra rocked yellow locks along with his bow tie. Fast forward to the early 2000s. Old Man Zoom donned several looks. The easiest change to see was his hair, from white to purple to orange. Other than the fact that has gotten bigger, I think the biggest change that we have done was in 2014, we added the decades project, said Moir.The decades project starts with the 1920s and is a way to highlight each decade as we get closer to Old Man Glooms 100th birthday. He was a snidely whiplash guy with a big mustache. Then we moved on to the '30s. He was old, bald and fat because that was the depression era. Zozobra had a little white hair left on this head and one button on his top.Then came 2016. The '40s we have the WWII era. That was a really big deal for us. That was really important because we were able to mark the 75th anniversary of the holocaust, said Moir. The marionette was dressed for the occasion with his double-breasted top, a fedora and a black tie.Part of the decades project is to teach kids about their past, not just Zozobra's past but what happened in New Mexico, what happened in the world, said Moir. That same year, the night before the event, a candlelight vigil was held to pay tribute to the victims and survivors of the Holocaust. Then in 2017, it was all about honoring the '50s. He was wearing a cardigan sweater and I would like to say he was father knows worst, instead of father knows best, said Moir. Zozobra had red hair to match his red nails.Then came the '60s. We really rolled out the entire hippie era 3:42 he tried to give the peace sign, but because he is Zozobra he really couldn't do that, said Moir.2018 was all groovy baby, with staff dressed in tie-dye as Old Man Gloom wore a bolo tie and had silver hair.Then last year, in 2019, disco was out to play. Coming in at 50 feet, 6 inches tall, it was all about the John Travolta look. Zozobra wore a white suit, gold medallion and blonde hair. His eyes were the memorable avocado green color and his lips were burnt orange. That was the first time his lips have changed color.2020 2 was slated to take us back to the '80s, but that is on hold until next year. Event organizers want this years focus to be the coronavirus. Zozobra will not wear a mask. Instead this show will honor first responders like our health care workers. The big question is, what will them marionette look like? His gray hair will take on the look of the virus itself, with orange pingpong balls and red hair scrunchies. His cuff-links will resemble murder hornets and they will be dipped in gold to bring out his formal attire. Last but not least, the buttons on his jacket will be stamped with the year 2020.

Old Man Gloom is 96 years old and he still looks great. But he never looks the same. Each year he grows taller, wears new clothes or has a different hair style. The evolution of Old Man Gloom is ever changing.

Hes one of the most notorious characters in New Mexico. You can call him a chameleon of the times. I feel in love with the guy. I would say he was my first boyfriend, said Zozobra Deputy Event Chair Judith Moir.

Black and white photos show Zozobra in the early years and key points in our history. As the years go on, Old Man Gloom becomes the monsters we need him to be. He becomes the villain of America. All the planning and design for Zozobra is done around the decade of his history, said Moir.

In 1982, the marionette has buttons along his top and a black belt. Then two years later, in 1984, he ditched some of his buttons for a bow tie, which would become his iconic look in the years to come. Then in 1985 and 1986, Old Man Gloom had orange hair.

Then the '90s Zozobra rocked yellow locks along with his bow tie. Fast forward to the early 2000s. Old Man Zoom donned several looks. The easiest change to see was his hair, from white to purple to orange. Other than the fact that has gotten bigger, I think the biggest change that we have done was in 2014, we added the decades project, said Moir.

The decades project starts with the 1920s and is a way to highlight each decade as we get closer to Old Man Glooms 100th birthday. He was a snidely whiplash guy with a big mustache. Then we moved on to the '30s. He was old, bald and fat because that was the depression era. Zozobra had a little white hair left on this head and one button on his top.

Then came 2016. The '40s we have the WWII era. That was a really big deal for us. That was really important because we were able to mark the 75th anniversary of the holocaust, said Moir. The marionette was dressed for the occasion with his double-breasted top, a fedora and a black tie.

Part of the decades project is to teach kids about their past, not just Zozobra's past but what happened in New Mexico, what happened in the world, said Moir. That same year, the night before the event, a candlelight vigil was held to pay tribute to the victims and survivors of the Holocaust.

Then in 2017, it was all about honoring the '50s. He was wearing a cardigan sweater and I would like to say he was father knows worst, instead of father knows best, said Moir. Zozobra had red hair to match his red nails.

Then came the '60s. We really rolled out the entire hippie era 3:42 he tried to give the peace sign, but because he is Zozobra he really couldn't do that, said Moir.

2018 was all groovy baby, with staff dressed in tie-dye as Old Man Gloom wore a bolo tie and had silver hair.

Then last year, in 2019, disco was out to play. Coming in at 50 feet, 6 inches tall, it was all about the John Travolta look. Zozobra wore a white suit, gold medallion and blonde hair. His eyes were the memorable avocado green color and his lips were burnt orange. That was the first time his lips have changed color.

2020 2 was slated to take us back to the '80s, but that is on hold until next year. Event organizers want this years focus to be the coronavirus. Zozobra will not wear a mask. Instead this show will honor first responders like our health care workers.

The big question is, what will them marionette look like? His gray hair will take on the look of the virus itself, with orange pingpong balls and red hair scrunchies. His cuff-links will resemble murder hornets and they will be dipped in gold to bring out his formal attire. Last but not least, the buttons on his jacket will be stamped with the year 2020.

See the rest here:

'A villain of the times': The evolution of Zozobra - KOAT New Mexico

World Ultrasound Market Analysis and Forecasts 2020-2025 with Company Evolution Matrix and Company Profiles – Yahoo Finance

DUBLIN, Sept. 4, 2020 /PRNewswire/ -- The "Ultrasound Market by Technology (Diagnostic (2D, 3D, Doppler), Therapeutic (HIFU, ESWL)), Display (Color, B&W), Portability (Trolley, Compact, POC), Applications (Gynecology, Urology, Cardiology, Orthopedic), End user (Hospitals) - Global Forecasts to 2025" report has been added to ResearchAndMarkets.com's offering.

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The ultrasound market is projected to reach USD 8.2 billion by 2025 from USD 6.1 billion in 2020, at a CAGR of 6.1% during the forecast period. Growth of the market is mainly attributed to the technological advancements; increasing incidences of target diseases; rising patient preference for minimally invasive procedures; and growing public and private investments, funding, and grants are driving the growth of the global ultrasound market. However, stringent government regulations may restrict the growth of this market to a certain extent in the coming years.

Therapeutic ultrasound technology segment to register significant growth, during the forecast period.

On the basis of technology, the ultrasound market is segmented into diagnostic ultrasound and therapeutic ultrasound devices. The therapeutic ultrasound segment is expected to grow at a significant rate over the forecast period. Therapeutic ultrasound technologies include focused ultrasound and shockwave lithotripsy. The growth of this market is driven mainly by ongoing technological innovations in the field of focused ultrasound as well as the expansion of its application horizons.

The color ultrasound devices segment is expected to witness the highest growth in the ultrasound market, by device display, during the forecast period.

On the basis of the device display, the ultrasound market is segmented into black & white ultrasound and color ultrasound devices. The color ultrasound devices segment is expected to grow at the highest CAGR during the forecast period owing to the benefits offered by these devices, such as better image quality and higher image resolution. Also, the growing availability of advanced color ultrasound devices, coupled with the continuous decline in product cost across major countries and expanding distribution networks of major manufacturers across emerging countries, are expected to support the growth of this market segment during the forecast period.

The trolley/cart-based ultrasound systems segment is expected to account for the largest share of the ultrasound market, by system portability.

Based on system portability, the ultrasound market is segmented into trolley/cart-based ultrasound systems, compact/handheld ultrasound systems, and point-of-care (PoC) ultrasound systems. In 2019, the trolley/cart-based ultrasound systems segment is expected to account for the largest market share due to the growing adoption of these systems across major markets (as a result of their increasing use in emergency care and acute care settings in hospitals and healthcare institutions).

Asia Pacific market is expected to grow at the highest CAGR during the forecast period.

The Asia Pacific market is estimated to grow at the highest CAGR during the forecast period majorly due to the increasing healthcare expenditure across the region's major countries (especially India and China), growing public awareness about the therapeutic potential of ultrasound technologies, a continuous decrease in device costs (due to growing localized manufacturing and the presence of global market players), rising prevalence of target diseases, and the ongoing trend of device miniaturization.

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Key Topics Covered:

1 Introduction

2 Research Methodology

3 Executive Summary

4 Premium Insights

5 Market Overview

6 Ultrasound Market, by Technology

7 Ultrasound Market, by Device Display

8 Ultrasound Market, by System Portability

9 Ultrasound Market, by Application

10 Ultrasound Market, by End User

11 Ultrasound Market, by Region

12 Competitive Landscape

13 Company Evolution Matrix and Company Profiles

For more information about this report visit https://www.researchandmarkets.com/r/25w2b4

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World Ultrasound Market Analysis and Forecasts 2020-2025 with Company Evolution Matrix and Company Profiles - Yahoo Finance

Entertainment Evolution: What’s Happening to Content Due to COVID-19 (Part 1) – Disruptive Competition Project

Much of the content, industries, and people we enjoy watching has been upended by the COVID-19 pandemic. Live entertainment such as sporting events, concerts, and festivals has been particularly impacted. Among many negative impacts to the music industry, the most noticeable has been the cancellation of concerts and festivals worldwide. And sports, an industry that goes hand-in-hand with live entertainment, are struggling to maintain their 2020 seasons under the weight of the pandemic. This post is the first in a two-part series covering the shifts in entertainment due to COVID-19.

The music industry is experiencing massive upheaval due to COVID-19; everything from cancelled live concerts and festivals to delayed album releases, instrument and equipment sales, and the volume of music released has been affected. However, as most music festivals have been cancelled, many artists are pursuing live music through streaming events. Many creators are utilizing popular digital services as a means of holding virtual concerts. Artists, small and large alike, are performing live through services such as Instagram, YouTube, and Twitch. BTS, a K-pop group popular throughout the world, hosted Bang Bang Con: The Live in June, a live hour and a half online concert which received over 750,000 viewers across 107 countries and territories. And Fortnite partnered with Travis Scott this past April to hold Astronomical, a series of live in-game events centered around Travis Scotts music with multiple tour dates for players around the world to participate. Epic Games (the creator of Fortnite) reported that 27 million unique players participated in the Travis Scott event live 45 million times. More recently, a webcast series called Verzuz which pits artists against each other live on Instagram and allows the audience to vote on the winner, has garnered attention.

While the first major income stream for the music industry is live music, the second is recorded music, which includes streaming, digital downloads, licensing of music for movies, games, TV and advertising, and more. Many of these revenue streams have not been as negatively affected. In fact, streaming music now makes up nearly half of global recorded music revenue. However, the Coronavirus has altered how people are listening to music and as festivals and concerts are only just returning (some as an experiment in determining how the virus spreads), on-demand consumption of music is on the rise. Spotify recently reported that the daily habits of its consumers have shifted. Many bands and individual creators are utilizing popular digital services as a means of releasing their new music. Famously, Lil Nas X first uploaded the tune to Old Town Road on TikTok. Individuals are making more music than ever before and many services are playing host to these new creations. Further emphasizing the streaming and on-demand opportunities in the music industry, Amazon just expanded its music service by integrating Twitch live streams, which has seen rapid growth from musicians moving to the platform. Spotify appears to be following suit and developing a virtual events section as well.

Live professional sports have also experienced setbacks due to the Coronavirus, many of which paused or cancelled their seasons earlier this year. However, some sports at the collegiate and professional levels are attempting to make a comeback. While the Big Ten and PAC-12 have both decided to postpone their competitions through the end of this calendar year, the AAC, SEC, and Big 12 have yet to alter their plans. The NHL petitioned Canada to host their teams and hold their post season tournament up north. The MLB is also reportedly considering a playoff bubble similar to the NHL. While the MLS resumed play in a bubble with the MLS is Back Tournament, its actually set to become the first major North American sports league to try to hold games with fans in the stands. The MLS recently announced the continuation of the season, allowing teams to play back in their home markets with limited capacity for fans in the stadium. The NCAA had to cancel March Madness this year; however, the NBA has had success with their bubble and resumed their season July 30. The U.S. Open was live-streamed in August without fans. Additionally, the 2020 INDY 500 was watchable and streamable live and had no fans in the stands. While increased vigilance and heightened safety guidelines will likely continue for some time, sports as live entertainment are returning.

Live streaming video game services are also seeing growth due to the upward trend of the industry as a whole. And some sports are even turning to e-sports as a way to give consumers the sporting entertainment they want in one form or another. NASCAR recently embraced e-sports and in March Fox Sports said it would stream the full season of NASCARs virtual race series. Further, while the pandemic has forced the cancellation or postponement of certain e-sport events, e-sports as a whole is actually gaining notoriety as a result of this pandemic. Global e-sports revenue is expected to grow just beyond $1 billion by 2020 and live streaming is key to that growth.

After experiencing the disruption to their previous standards of business that COVID-19 has brought about, many individuals, businesses, and organizations have been forced to alter their practices to continue to operate through the changes wrought by the pandemic. However, even throughout the Coronavirus, one thing remains clear: live entertainment has gone digital and its still highly attractive. The next post in this series will discuss movies, television, and video games.

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Entertainment Evolution: What's Happening to Content Due to COVID-19 (Part 1) - Disruptive Competition Project

Ball Hill: The evolution of Coventry’s busiest shopping street – Coventry Live

Walsgrave Road, known locally as Ball Hill, was at one point a bustling centre for shopping, serving the residents of Stoke and Wyken for years.

Ask any local taxi driver to take you to Ball Hill and they'll know where to go.

Many Coventrians will have memories of picking up a bargain in Stardust or getting a slap up breakfast at the Rosebud cafe, or even queuing up outside Britton's sport shop for the latest CCFC strip.

Many of those shops are still there and Ball Hill remains a busy stretch, serving as one of the city's major bus routes.

But as Covid-19 put a stop to much of the footfall that once inhabited our region's high streets, how has Ball Hill fared? Have there been any shop closures and what do locals think?

Here's what happened when we paid a visit.

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We visited Ball Hill on a busy Thursday lunchtime, just as the sun arrived. A feeling of familiarity crept in as we queued up to the main junction to access the shopping area, most commuters into Coventry will have sat in a traffic jam on this stretch.

As we parked the car and wandered up to the top of the hill, families and couples milled about doing their shopping, and a huge queue snaked up to the high street from the bank.

We start at the top of the hill and head into Ade's plaza salon, a hair and beauty supplier who has had to diversify so she can keep her shop open.

Owner Ade Osunwe said: "Everyone is afraid. It is not easy, we are just trying to cope, it was busier before lockdown."

Her shop has been open since 2015, but it was only post-lockdown that she had to widen her offering from hair and beauty to general goods so that she could attract a bigger customer base.

The shelves groan as containers of peanuts and milk powder sit next to wigs and curl cream. Ms Osunwe said: "The rent on this high street is expensive. Everyone is shopping online now - the Government need to think of us.

"I have four children and we are not on benefits - how will we survive?"

We head across the road to the key and shoe repair shop, which current owner Dave Oates informed us has operated in this capacity for more than 80 years.

Mr Oates, who has owned the shop for five years, said: "The last three weeks have been really good, with students coming back landlords often come to me to get their keys cut."

And how has the shop recovered as shoppers have returned? "We do have regular customers and walk-ins, when we started [the shop] there were key cutters and shoe repairs everywhere, but slowly it's become a dying trade" he said.

Mr Oates said that trade just hasn't been the same since Covid-19, and despite the last few weeks "going back to normal", they were twice as busy last September.

As we continue down the hill, some of the businesses have their shutters rolled down and some have permanently closed like the Age UK charity shop.

A sign in the window read: "As this shop has permanently closed, please do not leave any donations outside this shop, thank you."

The was an incredibly popular spot for avid bargain hunters, at one point selling clothes for 99p, but it did not make it out of the Covid-19 lockdown.

A few doors down there is an empty unit where the once popular Boss Shoes stood. The family-ran shoe shop, which had been in the city for 32 years and had a warehouse in Tile Hill, closed at the start of the year.

A couple of hundred yards further down, we pop into the indoor arcade which houses a barber shop, butcher's shop, sweet shop and key cutters among others.

At the centre of Ball Hill is Coventry's Music Museum - a treasure trove of music history and with its very own 2-Tone village, it was voted one of the best museums in the Midlands on TripAdvisor a few years ago.

We finish off at Fiveways Fish Bar, on the corner of the busy Brays Lane and Clay Lane junction. The popular chippy has been in the area for 25 years and was closed for six weeks at the height of the Covid-19 pandemic.

Owner Mr Singh, who owns another chip shop locally, said that things have not returned to normal in the area. "It is definitely quieter, before the street was very busy. We are still busy at lunchtime, everywhere is the same," he said.

The area sits across the Upper Stoke ward and Lower Stoke ward. Public Health England 2017 data shows this part of the city to have just over 17,682 residents. The age group with the most people in is 25-64 and the smallest age group is the those aged over 85.

We asked local residents what they thought of the area and if they had any memories.

Martin Winstanley said: "1980. 269, Walsgrave Road. Bargain Bathrooms in between Stardust and The Rosebud Cafe. They did the best Polish sausage mash and cabbage! I worked selling bathrooms as a Saturday job. Great memories!"

Another resident added: "We live just by where youre standing - on Marlborough Road - it was fantastic to be able to shop during the Covid-19 lockdown, many of the independents really were a lifeline!"

Look: memories of Ball Hill over the years

Despite some of the local favourites closing down over this past year, Ball Hill remains a bit of an anomaly, with many of the independent businesses still standing, managing to trade over generations.

It is perhaps the only road in Coventry where you can get a fry up, order new blinds and do your weekly shop as you wait for your tyres to be fitted.

Things may have changed over the years, but one thing that is certain is that Ball Hill will never be quiet.

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Ball Hill: The evolution of Coventry's busiest shopping street - Coventry Live

Macau Cathedral to close in October for renovation – Macau News

Macaos Catholic Cathedral will close next month for about nine months for renovation, the Portuguese-language radio channel of public broadcaster TDM reported today.

According to the report, the project is estimated to cost around 9 million patacas (US$1.1 million). The report did not indicate the source of the estimate, nor how it will be financed.

The report cited the cathedrals vicar, Fr Daniel Ribeiro, as saying that at the request of the government the project includes structural strengthening.

The concrete building of the Cathedral of the Nativity of Our Lady was constructed in 1937, which replaced an edifice built in 1850 that was badly damaged by a typhoon in 1874. A small wooden chapel built in the present location was elevated to cathedral in 1623, according to information provided by the diocese.

The report also said that the installation of a large and weighty organ donated to the diocese will require structural strengthening of the nave.

Fr Ribeiro told Radio Macau that the government requested the renovation project as some parts of the building are believed to be in risk of collapse. The report pointed out that some of the present building structure dates back to the 18th century.

Fr Ribeiro also said that from next month the Masses customarily celebrated at the Cathedral will take place at the nearby S. Domingos Church during the renovation project, following the same schedule.

According to the report, the renovated Cathedral is slated to reopen next June. However, Fr Ribeiro admitted that possible complications could delay the reopening.

Macaus Catholic diocese, which was founded in 1576, comprises 11 churches in nine parishes. According to its website, the diocese runs 31 education establishments and 22 social service institutions.

An introduction to the diocese on the website estimates its flock at 30,000 or about 4.5 per cent of the population.

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Macau Cathedral to close in October for renovation - Macau News

Macau marathon to be held with infection control measures – Macau Daily Times

The Galaxy Entertainment Macao International Marathon will be held on December 6, opening with a total of 12,000 spots available for participants, the Sports Bureau (ID) announced in a press conference.Registration for the marathon and half marathon will open to the public on September 12. Registration for the mini marathon will open on September 13.The 38th iteration of the event will have 1,400 spots available for the marathon, 4,800 for the half marathon and 5,800 for the mini marathon.The full marathon and half marathon courses will start at Governor Nobre de Carvalho Bridge, pass World Heritage site A-Ma Temple and run along the Sai Van Bridge.The marathon and half marathon races will start at 6 a.m., while the mini-marathon will kick off at 6:15 a.m.Registrants who opt for on-site registration may go to the Tap Seac Multisport Pavilion from 9 a.m. to 6 p.m. on September 12 and 13. They should bring the completed registration form, a copy of their identification document, membership card from the General Association of Athletics of Macau for the current year and the registration fee.Galaxy Entertainment Group will sponsor the event until 2021, following the renewal of their title sponsorship for the event last year.The marathon is one of the few events in the city that will occur despite the ongoing pandemic. Macau has not seen a new locally-transmitted case of Covid-19 for several months.The ID said that it will pay close attention to the Covid-19 pandemic and will adopt preventive measures according to the guidelines by the Health Bureau.Meanwhile, there was no information given about what will happen to foreign athletes who are keen on participating in the marathon.If foreigners and non-resident workers are still not allowed to enter the city prior to the date of the marathon, the event will likely be held with athletes from mainland China and Hong Kong only.

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Macau marathon to be held with infection control measures - Macau Daily Times

New urban plan to expand Macau tourism areas but casino activity to remain within current locations – Inside Asian Gaming

The draft of the Master Plan for Macaus urban development has revealed that the future of the SARs tourism and entertainment industries would remain in the current Cotai and NAPE areas, while several locations would become new non-gaming tourism areas.

The draft, launched on Thursday, separated and classified various functions for different districts in Macau. According to the drafts suggestions, the core tourism and entertainment industries would remain in their current areas.

Officials of the Macau SAR Government said at a press conference that casinos would be mainly based in and around hotels in these areas, however the government will keep a certain level of flexibility in considering the compatibility of land in practice.

Meanwhile, the northern part of Taipa, currently referred to as new urban area zones C and D, would become an urban waterfront area via the development of tourism and business elements.

The government also plans to build a new tourism and leisure route along with the new urban area B, Nam Van and Barra areas in order to enrich entertainment experiences in Macau.

The southern part of the artificial island upon which the Hong Kong-Zhuhai-Macau Bridge boundary sits would be reserved for the development of hotels, exhibitions and conventions in order to promote a platform of cooperation between the three cities.

With the re-tendering of gaming licenses scheduled for 2022, when the six current concessions expire, the distribution of land for gaming operators and further development of tourism industries in Macau would be a focus in the foreseeable future.

A public consultation for the draft will be held from 4 September to 2 November 2020.

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New urban plan to expand Macau tourism areas but casino activity to remain within current locations - Inside Asian Gaming

Aollywood (Macau-Hollywood, the Eastern Hollywood) established the first Film Critics Association in Macau, China – Business Wire

MACAU, China--(BUSINESS WIRE)--Recently, the high-profile Aollywood Film Critics Association declared to establish in Macau, China. This is one of the film industry associations founded by Aollywood which is Eastern Hollywood founded in Macau, China. It is committed to speaking out for the establishment of Chinese films international discourse power, aesthetic standards and evaluation system. Moreover, its mission is to enable outstanding Chinese films to receive objective and fair evaluation from overseas and to help build the bridge between Chinese films and other films from all over the world.

The Aollywood Film Critics Association board members elected a new leadership team, and the chairman is the famous film critic Zhou Liming; the vice-chairmen are Mao Jian, Lie Fu, Wei Junzi, Song Ziwen, and Zuo Heng; the secretary-general is Hu Jianli. In addition, Alang was elected as the supervisor of the association and the members are senior film critics Li Xingwen, Han Haoyue, Tan Fei, Ye Hang and other 25 people. These scholars are all well-known Chinese film critics.

Zhou Liming, the chairman of the Aollywood Film Critics Association, said that film criticism is a link in the entire film ecosystem. Film critics need to provide evaluations of films, provide guidance to audiences, and provide feedback to the filmmakers. He hopes that the Aollywood Film Critics Association can help the healthy development of Chinese film industry, discover more potential successful filmmakers, recommend more excellent films, and grow together with the whole Chinese film industry.

It is also reported that the Aollywood Film Critics Association will participate in hosting of the Aollywood International Film Festival.

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Aollywood (Macau-Hollywood, the Eastern Hollywood) established the first Film Critics Association in Macau, China - Business Wire

Ulysse Nardin – The brand and DFS Present Sharks in Macau Exhibition – Events – WorldTempus

Xploring has become Ulysse Nardins motivation, and the result is a universe of X-factor: X like an adventure, X like our deepest desires, X for the unknown, X for whats forbidden, bold and exciting. To bring this sense of exploration to life, Ulysse Nardin has partnered with DFS Group, the worlds leading luxury travel retailer, on the Sharks in Macau exhibition at T Galleria by DFS, Macau, City of Dreams. Inspired by the discovery of the mysterious underwater world, the pop up features Ulysse Nardins first interactive shark photobooth in Asia Pacific where adventurers can dive into the deep sea and experience a thrilling moment with ferocious and dangerous sharks suddenly appearing and attacking courageous divers.

To celebrate the opening of the pop up store, Ulysse Nardin presents the below novelty and high complication pieces:

The SKELETON X case, reshaped and very small, a mere 42mm, is perfectly on-trend: more angular, more masculine, less round. Its shape-within-shape-within-shape geometry - an X formed by four of the indexes is framed in a rectangle, in turn inside a circle - delights the eye. Inside and clearly visible beats one of the star innovations of the watchs antecedent: a super-light balance wheel in silicium, extra-wide, with nickel flyweights and stabilizing micro-blades. The new Manufacture movement, the UN-371 caliber has 96-hour power reserve can be read through the back by means of windows, like those in the barrel. The SKELETON X eXists in four different satin-finish versions: satin-finish titani-um blue, satin-finish titanium black, satin-finish rose gold or matte-finish Carbonium GOLD.

Skeleton X Ulysse Nardin

The FREAK X, the little cousin of its Freak antecedents, stands out as the entry point into the FREAK collection. It has a crown for time correction, which breaks with one of the most iconic as-pects of the previous crown-less FREAK models. The sizing is tighter - 43mm. The baguette move-ment is still a carousel, turning once on itself every hour to indicate the time. It is simpler, bolder, and has fewer wheels. It has no dial and no hands - the central bridge acts as a minute hand and one of the wheels indicates the hours.

FREAK X Ulysse Nardin

From now until December 31, 2020, Ulysse Nardin timepieces will be showcased in T Galleria by DFS, Macau, City of Dreams. Do you dare to explore this deep-sea adventure?

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Ulysse Nardin - The brand and DFS Present Sharks in Macau Exhibition - Events - WorldTempus

Govt collaborates with gaming operators to promote in Beijing – Macau Daily Times

The government is set to launch a tourism promotion campaign during the second week of September on Beijings busiest commercial street. The campaign will involve the citys six gaming concessionaires.According to a report by Radio Macau, the promotional campaign, which is being coordinated by the MacaoGovernment Tourism Office (MGTO), will take place on Wangfujing Street in Beijing.This is the first tourism campaign being run abroad since the start of the Covid-19 pandemic.During the first half of 2020, visitor arrivals declined by 84% year-on-year to 3.26 million due to travel and border restrictions.Last month, China had set a date for the resumption of tourist visas for visitors travelling to the Macau SAR. From September 23, any mainland resident will be able to apply for an Individual Visit Scheme (IVS) visa to visit Macau for tourism purposes.The timing positions Macau for a tourism recovery bounce during Chinas Golden Week in early October, a normally popular time in the Macau gaming calendar.As the promotion of gambling is prohibited on the mainland, gaming operators are likely to publicize their hotel and restaurant promotions during the upcoming campaign.Recently, the government launched a scheme for tourists from mainland China, aiming to boost the economy and protect local jobs.The scheme was initiated by the Macau SAR government with support from e-commerce giants Tencent and Alibaba, as well as Air Macau. It aims to attract tourism to the city through promotions on air tickets and hotels, and rebates on shopping and dining to encourage tourists to increase their spending and length of stay.After the IVS was reinstated for Guangdong residents on August 12, preliminary data shows that the city recorded a 25% rise in visitor arrivals compared to the weekend prior.Previously, the Public Security Police Force had said that it did not expect significant changes in border traffic. However, they are now predicting a gradual upward trend in the number of arrivals in the coming weeks.

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Govt collaborates with gaming operators to promote in Beijing - Macau Daily Times

China says Czech visit to Taiwan harmed its sovereignty – Macau Business

The Chinese embassy in Prague on Saturday condemned this weeks visit to Taiwan by a Czech delegation as a serious infringement on Chinas national sovereignty.

A delegation of about 90 Czech politicians, entrepreneurs, scientists and journalists led by senate speaker Milos Vystrcil visited Taiwan from August 30 to September 4.

Under its One China policy, Beijing considersTaiwana part of its territory and does not send official delegations to the island.

TheCzechcentre-left government officially accepts the One China policy, but Vystrcil is a member of the right-wing opposition Civic Democrats and is not bound by the protocol.

The embassy said the visit was a serious interference in Chinas internal affairs and called on the Czech Republic to take specific steps to remove the unfavourable impact of the said incident.

There is only one China in the world and Taiwan is an inseparable part of its territory, it said.

No matter what manipulation the Taiwanese authorities and anti-China forces come up with, they cannot change this.

On Monday, Chinese Foreign Minister Wang Yi described the trip as a provocation, saying that China would make Vystrcil pay a high price for his short-sighted behaviour.

The Czech foreign ministry then summoned Chinas ambassador to Prague and Beijing followed suit.

Vystrcil gave a speech inTaiwans parliament and met President Tsai Ing-wen, whose re-election earlier this year upset China as she views the island as a sovereign nation.

Ties between Prague and China suffered a blow last October when Prague city hall, run by a mayor from the anti-establishment Pirate Party, pulled out of a twinning deal with Beijing over its insistence on the One China policy.

Prague mayor Zdenek Hrib, who was on Vystrcils delegation, then signed a partnership agreement with Taipei in January, triggering outrage in Beijing.

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China says Czech visit to Taiwan harmed its sovereignty - Macau Business

Trump in ‘different reality’ on racism: Harris – Macau Business

Democratic vice presidential candidate Kamala Harris said Sunday that President Donald Trump is living in a different reality when he denies there is systemic racism in America.

The reality of America today is what we have seen over generations and, frankly, since our inception, which is we do have two systems of justice in America, Harris told CNN.

I think that Donald Trump and Bill Barr are spending full time in a different reality, said Harris, the first woman of color on a major US White House ticket taking aim at the president and his attorney general.

Joe Bidens running mate spoke two days after the White House disclosed that Trump had ordered federal agencies to stop funding anti-racism training sessions for employees, saying they amount to divisive, un-American propaganda that suggests the country is inherently racist.

And last week Barr dismissed the idea that there is, effectively, one justice system for whites in the United States and another for blacks.

I think we have to be a little careful about throwing the idea of racism around, Barr said. I dont think it is as common as people suggest.

Trump is working feverishly to appeal to his largely white, blue-collar base with a tough law-and-order mantra while fighting an uphill battle for re-election amid a pandemic, a struggling economy and a fraught national reckoning over racial injustice in policing and other walks of life.

Protests in major US cities erupted after the death of African American George Floyd in May at the hands of a white police officer in Minneapolis, and flared up again last month after another black man, Jacob Blake, was shot in the back repeatedly by a white policeman in Kenosha, Wisconsin.

Trump has blasted such demonstrators as violent anarchists.

Harris insisted that peaceful protest is an American right and that racism is indeed embedded in the country.

I dont think that most reasonable people who are paying attention to the facts would dispute that there are racial disparities and a system that has engaged in racism in terms of how the laws have been enforced, said Harris.

She blasted Trump as having bungled the nations handling of the coronavirus pandemic, which has killed nearly 190,000 people in America, and for not doing enough to help millions of people left jobless or otherwise suffering as a result of the global health crisis.

There is no question that Donald Trump has been an abject failure and incompetent when it comes to addressing the severe job loss that has happened as a result of the pandemic, because he has failed to address the pandemic itself, she said.

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Trump in 'different reality' on racism: Harris - Macau Business

First Clone of Endangered Przewalskis Horse Born in Conservation Effort to Save the Species – TIME

The first successfully cloned endangered Przewalskis horse was born on Aug. 6 in a veterinary facility in Texas, San Diego Zoo Global announced on Friday. The horse was cloned from DNA of a male Przewalskis horse cryopreserved by the zoo in 1980.

Przewalskis horses are critically endangered animals that are found in Mongolia, per Smithsonians National Zoo. Theyre considered the last species of truly wild horses and are distant cousins of modern day domestic horses, having likely split from a common ancestor around 500,000 years ago, per the Smithsonian.

Przewalskis horses were once extinct in the wild, and while intensive breeding programs helped revive the species and reintroduce them into the grasslands of China and Mongolia, nearly all can be traced back to 12 Przewalskis horses that were born in the wild, the San Diego Zoo said in its press release. The successful cloning of DNA collected 40 years is meant to introduce key generic diversity into the species that could benefit its survival. The zoo said the cloned Przewalskis horse will eventually be transferred to the San Diego Zoo Safari Park and integrated into a herd of other Przewalskis horses for breeding.

The work to save endangered species requires collaborative and dedicated partners with aligned goals, Paul A. Baribault, president of San Diego Zoo Global, said in a statement. We share in this remarkable achievement because we applied our multidisciplinary approach, working with the best scientific minds and utilizing precious genetic material collected and stored in our wildlife DNA bio bank.

The cloned Przewalskis horse was named Kurt after Dr. Kurt Benirschke, the creator of the San Diego Zoo Global Frozen Zoo, which has been collecting and preserving genetic material of endangered animals since 1975.

San Diego Zoo Global partnered with Revive & Restorea wildlife conservation group that aims to incorporate biotechnology into conservation effortsand ViaGen Equinea company that clones horses and petsto successfully clone the Przewalskis horse.

This birth expands the opportunity for genetic rescue of endangered wild species, said Ryan Phelan, executive director of Revive & Restore, in a statement. Advanced reproductive technologies, including cloning, can save species by allowing us to restore genetic diversity that would have otherwise been lost to time.

Przewalskis horses are not the only species Revive & Restore is trying to revive via biotechnology. The group is attempting to revive at least six endangered or extinct species, including the Wooly Mammoth, which went extinct around 4,000 years ago. Other organizations and research facilities are also attempting to revive extinct or endangered species with biotechnology, including the International Islamic University Malaysia, which plans to revive the recently extinct Sumatran rhino.

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Write to Madeleine Carlisle at madeleine.carlisle@time.com.

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First Clone of Endangered Przewalskis Horse Born in Conservation Effort to Save the Species - TIME

Cloning Crescendo: US Open Computer Crowd Noise Fills The Void of No Fans – Tennis Now

By Erik Gudris

The US Open is known for its often raucous, vocal fans who make themselves heard everywhere.

But when it was announced that this years US Open would not have spectators on site, many tennis watchers wondered how that might impact not only the players, but the overall experience of the event.

More: Ashe Experience Special for Tsitsipas, Auger-Aliassime

Tournament organizers turned to IBM to help them provide a solutionAI (artificial intelligence) generated crowd noise. Using technology called AI Sounds, engineers digested video from last years US Open and then ranked the excitement level of various video clips. These clips were then turned into a reel and then classified to create a crowd reaction score.

From a player hitting an ace, to saving a break point, or winning a match, all these various sounds were then made available to in-stadium and television production crews covering this years event to use the sounds depending on whats happening in a match during real-time.

COVID-19 brought disruption to sports as a whole, and the ability of fans to experience live sporting events has been heavily impacted in 2020. At the same time, the pandemic accelerated the need for engaging technologies using AI and underpinned by a scalable hybrid cloud," said Noah Syken, Vice President of Sports & Entertainment Partnerships, IBM. "As the technology partner to the USTA, we transformed our offerings to meet tennis fans where they are this yearexperiencing the sport through the US Open digital properties everywhere.

These sounds are definitely noticeable in matches being played at the site two biggest courtsArthur Ashe Stadium and Louis Armstrong Stadium. Without them, it sometimes feels like the players are competing inside an empty parking lot, rather than inside one of the sports most prestigious stages.

Using digital sounds in sporting events is nothing new; even before the current pandemic prompted many sports leagues to not allow fans at their respective matches or games.

According to the New York Times, 20 years ago CBS used taped nature sounds during a PGA golf event that drew criticism from bird experts over the use of such sounds. Nowadays, the practice is more common.

European football leagues when they returned to action this summer are employing virtual stadium noises created for FIFA video games. The National Football League (NFL) is considering using artificial crowd sounds during football games this fall.

Getting back to tennis, fans watching at home are divided over the non-natural sounds being used in New York. Some fans like that it adds some atmosphere for them as they cheer on their favorite pros. Others dont like the artificial sounds and would prefer experiencing the court as it is.

For the players themselves, although they would prefer to have fans on-site, not having fans this year is just one more thing they have to adjust to during this very different U.S. Open.

It's digital fans. It's 2020, Serena Williams said when asked about not having fans on site. Im all about the future. I'm glad we're able to have the Open.

"It's really cool that we can have it. It's so important that this is justwe don't know what the new normal is going to be. So it's just good that we can have virtual fans and be able to have sport.

Photo credit: Andrew Ong/USTA

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Cloning Crescendo: US Open Computer Crowd Noise Fills The Void of No Fans - Tennis Now

Can love be replicated? – The Times of India Blog

Why chase after an ideal or a lost love? Each love is unique and cannot be cloned, no matter what!

You can never love any two or more people in the same manner and with the same intensity. Love is an emotion of a myriad hues, never experienced in exactly the same way by different people. And never again even by the same two people in an unchanged form. This is because love is dependent on so many variable factors that it cannot possibly be replicated.

The love that two people share stems from their individual needs, mutual chemistry, and also from their own capacity to give and receive the emotion. It is dependent on individual personal characteristics, and each persons experiences and unique circumstances also have a deep bearing on the outcome. This accounts for the rather changeable nature of love.

Not all loves, nor indeed all relationships, can feed the same need in you. Physical need is just one aspect; we also have emotional needs, spiritual and intellectual needs, and some needs that we ourselves may not understand. Hence you get attracted to other people and at any given time, could theoretically have loving relationships with multiple people. Needs vary, and so a relationship based on need, would vary too.

The only people who can love everyone in exactly the same manner, repeating the same experiences, are almost certainly psychopaths, or at least sociopaths, using their bookish understanding of the emotion to exploit others. In short, these are people just acting out the emotion.

We waste a lifetime in the impossible pursuit of an ideal love or the recreation of a love we once had and lost but cloning is not part of the Love DNA! You cannot ever experience the love of a Romeo and Juliet however hard you try, because that love was the product of their circumstances and the interplay of their individual characteristics and chemistry at a certain time in history, placed in a unique geographical setting. How can you possibly love like them, when you are not them? Heck, even if Romeo and Juliet were themselves to step out of Shakespeares pages, with changed variables, they cannot possibly love the same way again! This time round they might end up happily married, growing old together or splitting paths along the way!

You can certainly love several times in your lifetime, sometimes simultaneously too, but never ever in the exact same manner, clocking the same experiences and emotion. That is impossible because we change and evolve as we go along in life, and our needs and dependencies change too. Time and experience teach us better control of our emotions, patience, forgiveness and self-sufficiency. Conversely, bad experiences at love and relationships may lead to bitterness and cynicism in some.

So, if people change so much and so do their needs, how then can our experience of love remain the same? Love changes too. And that is what makes it so precious, so unique to each. Why look for a clone when you can create your own unique love?

DISCLAIMER : Views expressed above are the author's own.

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Can love be replicated? - The Times of India Blog

Growing Focus on Product Innovation Likely to Impact the Growth of the Fosmid Cloning Market 2017 2025 – StartupNG

Persistence Market Research recently published a market study that sheds light on the growth prospects of the global Fosmid Cloning market during the forecast period (20XX-20XX). In addition, the report also includes a detailed analysis of the impact of the novel COVID-19 pandemic on the future prospects of the Fosmid Cloning market. The report provides a thorough evaluation of the latest trends, market drivers, opportunities, and challenges within the global Fosmid Cloning market to assist our clients arrive at beneficial business decisions.

The recent published research report sheds light on critical aspects of the global Fosmid Cloning market such as vendor landscape, competitive strategies, market drivers and challenges along with the regional analysis. The report helps the readers to draw a suitable conclusion and clearly understand the current and future scenario and trends of global Fosmid Cloning market. The research study comes out as a compilation of useful guidelines for players to understand and define their strategies more efficiently in order to keep themselves ahead of their competitors. The report profiles leading companies of the global Fosmid Cloning market along with the emerging new ventures who are creating an impact on the global market with their latest innovations and technologies.

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The recent published study includes information on key segmentation of the global Fosmid Cloning market on the basis of type/product, application and geography (country/region). Each of the segments included in the report is studies in relations to different factors such as market size, market share, value, growth rate and other quantitate information.

The competitive analysis included in the global Fosmid Cloning market study allows their readers to understand the difference between players and how they are operating amounts themselves on global scale. The research study gives a deep insight on the current and future trends of the market along with the opportunities for the new players who are in process of entering global Fosmid Cloning market. Market dynamic analysis such as market drivers, market restraints are explained thoroughly in the most detailed and easiest possible manner. The companies can also find several recommendations improve their business on the global scale.

The readers of the Fosmid Cloning Market report can also extract several key insights such as market size of varies products and application along with their market share and growth rate. The report also includes information for next five years as forested data and past five years as historical data and the market share of the several key information.

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Global Fosmid Cloning Market by Companies:

The company profile section of the report offers great insights such as market revenue and market share of global Fosmid Cloning market. Key companies listed in the report are:

Key Participants

The key participants in fosmid cloning Market are Bio S&T, Illumina, Inc., Lucigen, and others. The companies are mainly focusing on intense marketing to convey benefits of fosmid cloning.

The report covers exhaustive analysis on:

Regional analysis for Market includes

Report Highlights:

Global Fosmid Cloning Market by Geography:

For any queries get in touch with Industry Expert @ https://www.persistencemarketresearch.co/ask-an-expert/19651

Some of the Major Highlights of TOC covers in Fosmid Cloning Market Report:

Chapter 1: Methodology & Scope of Fosmid Cloning Market

Chapter 2: Executive Summary of Fosmid Cloning Market

Chapter 3: Fosmid Cloning Industry Insights

Chapter 4: Fosmid Cloning Market, By Region

Chapter 5: Company Profile

And Continue

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Growing Focus on Product Innovation Likely to Impact the Growth of the Fosmid Cloning Market 2017 2025 - StartupNG

What Is Artificial Intelligence (AI)? | PCMag

In September 1955, John McCarthy, a young assistant professor of mathematics at Dartmouth College, boldly proposed that "every aspect of learning or any other feature of intelligence can in principle be so precisely described that a machine can be made to simulate it."

McCarthy called this new field of study "artificial intelligence," and suggested that a two-month effort by a group of 10 scientists could make significant advances in developing machines that could "use language, form abstractions and concepts, solve kinds of problems now reserved for humans, and improve themselves."

At the time, scientists optimistically believed we would soon have thinking machines doing any work a human could do. Now, more than six decades later, advances in computer science and robotics have helped us automate many of the tasks that previously required the physical and cognitive labor of humans.

But true artificial intelligence, as McCarthy conceived it, continues to elude us.

A great challenge with artificial intelligence is that it's a broad term, and there's no clear agreement on its definition.

As mentioned, McCarthy proposed AI would solve problems the way humans do: "The ultimate effort is to make computer programs that can solve problems and achieve goals in the world as well as humans," McCarthy said.

Andrew Moore, Dean of Computer Science at Carnegie Mellon University, provided a more modern definition of the term in a 2017 interview with Forbes: "Artificial intelligence is the science and engineering of making computers behave in ways that, until recently, we thought required human intelligence."

But our understanding of "human intelligence" and our expectations of technology are constantly evolving. Zachary Lipton, the editor of Approximately Correct, describes the term AI as "aspirational, a moving target based on those capabilities that humans possess but which machines do not." In other words, the things we ask of AI change over time.

For instance, In the 1950s, scientists viewed chess and checkers as great challenges for artificial intelligence. But today, very few would consider chess-playing machines to be AI. Computers are already tackling much more complicated problems, including detecting cancer, driving cars, and processing voice commands.

The first generation of AI scientists and visionaries believed we would eventually be able to create human-level intelligence.

But several decades of AI research have shown that replicating the complex problem-solving and abstract thinking of the human brain is supremely difficult. For one thing, we humans are very good at generalizing knowledge and applying concepts we learn in one field to another. We can also make relatively reliable decisions based on intuition and with little information. Over the years, human-level AI has become known as artificial general intelligence (AGI) or strong AI.

The initial hype and excitement surrounding AI drew interest and funding from government agencies and large companies. But it soon became evident that contrary to early perceptions, human-level intelligence was not right around the corner, and scientists were hard-pressed to reproduce the most basic functionalities of the human mind. In the 1970s, unfulfilled promises and expectations eventually led to the "AI winter," a long period during which public interest and funding in AI dampened.

It took many years of innovation and a revolution in deep-learning technology to revive interest in AI. But even now, despite enormous advances in artificial intelligence, none of the current approaches to AI can solve problems in the same way the human mind does, and most experts believe AGI is at least decades away.

The flipside, narrow or weak AI doesn't aim to reproduce the functionality of the human brain, and instead focuses on optimizing a single task. Narrow AI has already found many real-world applications, such as recognizing faces, transforming audio to text, recommending videos on YouTube, and displaying personalized content in the Facebook News Feed.

Many scientists believe that we will eventually create AGI, but some have a dystopian vision of the age of thinking machines. In 2014, renowned English physicist Stephen Hawking described AI as an existential threat to mankind, warning that "full artificial intelligence could spell the end of the human race."

In 2015, Y Combinator President Sam Altman and Tesla CEO Elon Musk, two other believers in AGI, co-founded OpenAI, a nonprofit research lab that aims to create artificial general intelligence in a manner that benefits all of humankind. (Musk has since departed.)

Others believe that artificial general intelligence is a pointless goal. "We don't need to duplicate humans. That's why I focus on having tools to help us rather than duplicate what we already know how to do. We want humans and machines to partner and do something that they cannot do on their own," says Peter Norvig, Director of Research at Google.

Scientists such as Norvig believe that narrow AI can help automate repetitive and laborious tasks and help humans become more productive. For instance, doctors can use AI algorithms to examine X-ray scans at high speeds, allowing them to see more patients. Another example of narrow AI is fighting cyberthreats: Security analysts can use AI to find signals of data breaches in the gigabytes of data being transferred through their companies' networks.

Early AI-creation efforts were focused on transforming human knowledge and intelligence into static rules. Programmers had to meticulously write code (if-then statements) for every rule that defined the behavior of the AI. The advantage of rule-based AI, which later became known as "good old-fashioned artificial intelligence" (GOFAI), is that humans have full control over the design and behavior of the system they develop.

Rule-based AI is still very popular in fields where the rules are clearcut. One example is video games, in which developers want AI to deliver a predictable user experience.

The problem with GOFAI is that contrary to McCarthy's initial premise, we can't precisely describe every aspect of learning and behavior in ways that can be transformed into computer rules. For instance, defining logical rules for recognizing voices and imagesa complex feat that humans accomplish instinctivelyis one area where classic AI has historically struggled.

An alternative approach to creating artificial intelligence is machine learning. Instead of developing rules for AI manually, machine-learning engineers "train" their models by providing them with a massive amount of samples. The machine-learning algorithm analyzes and finds patterns in the training data, then develops its own behavior. For instance, a machine-learning model can train on large volumes of historical sales data for a company and then make sales forecasts.

Deep learning, a subset of machine learning, has become very popular in the past few years. It's especially good at processing unstructured data such as images, video, audio, and text documents. For instance, you can create a deep-learning image classifier and train it on millions of available labeled photos, such as the ImageNet dataset. The trained AI model will be able to recognize objects in images with accuracy that often surpasses humans. Advances in deep learning have pushed AI into many complicated and critical domains, such as medicine, self-driving cars, and education.

One of the challenges with deep-learning models is that they develop their own behavior based on training data, which makes them complex and opaque. Often, even deep-learning experts have a hard time explaining the decisions and inner workings of the AI models they create.

Here are some of the ways AI is bringing tremendous changes to different domains.

Self-driving cars: Advances in artificial intelligence have brought us very close to making the decades-long dream of autonomous driving a reality. AI algorithms are one of the main components that enable self-driving cars to make sense of their surroundings, taking in feeds from cameras installed around the vehicle and detecting objects such as roads, traffic signs, other cars, and people.

Digital assistants and smart speakers: Siri, Alexa, Cortana, and Google Assistant use artificial intelligence to transform spoken words to text and map the text to specific commands. AI helps digital assistants make sense of different nuances in spoken language and synthesize human-like voices.

Translation: For many decades, translating text between different languages was a pain point for computers. But deep learning has helped create a revolution in services such as Google Translate. To be clear, AI still has a long way to go before it masters human language, but so far, advances are spectacular.

Facial recognition: Facial recognition is one of the most popular applications of artificial intelligence. It has many uses, including unlocking your phone, paying with your face, and detecting intruders in your home. But the increasing availability of facial-recognition technology has also given rise to concerns regarding privacy, security, and civil liberties.

Medicine: From detecting skin cancer and analyzing X-rays and MRI scans to providing personalized health tips and managing entire healthcare systems, artificial intelligence is becoming a key enabler in healthcare and medicine. AI won't replace your doctor, but it could help to bring about better health services, especially in underprivileged areas, where AI-powered health assistants can take some of the load off the shoulders of the few general practitioners who have to serve large populations.

In our quest to crack the code of AI and create thinking machines, we've learned a lot about the meaning of intelligence and reasoning. And thanks to advances in AI, we are accomplishing tasks alongside our computers that were once considered the exclusive domain of the human brain.

Some of the emerging fields where AI is making inroads include music and arts, where AI algorithms are manifesting their own unique kind of creativity. There's also hope AI will help fight climate change, care for the elderly, and eventually create a utopian future where humans don't need to work at all.

There's also fear that AI will cause mass unemployment, disrupt the economic balance, trigger another world war, and eventually drive humans into slavery.

We still don't know which direction AI will take. But as the science and technology of artificial intelligence continues to improve at a steady pace, our expectations and definition of AI will shift, and what we consider AI today might become the mundane functions of tomorrow's computers.

Further Reading

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What Is Artificial Intelligence (AI)? | PCMag

How AI will automate cybersecurity in the post-COVID world – VentureBeat

By now, it is obvious to everyone that widespread remote working is accelerating the trend of digitization in society that has been happening for decades.

What takes longer for most people to identify are the derivative trends. One such trend is that increased reliance on online applications means that cybercrime is becoming even more lucrative. For many years now, online theft has vastly outstripped physical bank robberies. Willie Sutton said he robbed banks because thats where the money is. If he applied that maxim even 10 years ago, he would definitely have become a cybercriminal, targeting the websites of banks, federal agencies, airlines, and retailers. According to the 2020 Verizon Data Breach Investigations Report, 86% of all data breaches were financially motivated. Today, with so much of societys operations being online, cybercrime is the most common type of crime.

Unfortunately, society isnt evolving as quickly as cybercriminals are. Most people think they are only at risk of being targeted if there is something special about them. This couldnt be further from the truth: Cybercriminals today target everyone. What are people missing? Simply put: the scale of cybercrime is difficult to fathom. The Herjavec Group estimates cybercrime will cost the world over $6 trillion annually by 2021, up from $3 trillion in 2015, but numbers that large can be a bit abstract.

A better way to understand the issue is this: In the future, nearly every piece of technology we use will be under constant attack and this is already the case for every major website and mobile app we rely on.

Understanding this requires a Matrix-like radical shift in our thinking. It requires us to embrace the physics of the virtual world, which break the laws of the physical world. For example, in the physical world, it is simply not possible to try to rob every house in a city on the same day. In the virtual world, its not only possible, its being attempted on every house in the entire country. Im not referring to a diffuse threat of cybercriminals always plotting the next big hacks. Im describing constant activity that we see on every major website the largest banks and retailers receive millions of attacks on their users accounts every day. Just as Google can crawl most of the web in a few days, cybercriminals attack nearly every website on the planet in that time.

The most common type of web attack today is called credential stuffing. This is when cybercriminals take stolen passwords from data breaches and use tools to automatically log in to every matching account on other websites to take over those accounts and steal the funds or data inside them. These account takeover (ATO) events are possible because people frequently reuse their passwords across websites. The spate of gigantic data breaches in the last decade has been a boon for cybercriminals, reducing cybercrime success to a matter of reliable probability: In rough terms, if you can steal 100 users passwords, on any given website where you try them, one will unlock someones account. And data breaches have given cybercriminals billions of users passwords.

Above: Source: Attacks Against Financial Services via F5 Security Incident Response Team in 2017-2019

Whats going on here is that cybercrime is a business, and growing a business is all about scale and efficiency. Credential stuffing is only a viable attack because of the large-scale automation that technology makes possible.

This is where artificial intelligence comes in.

At a basic level, AI uses data to make predictions and then automates actions. This automation can be used for good or evil. Cybercriminals take AI designed for legitimate purposes and use it for illegal schemes. Consider one of the most common defenses attempted against credential stuffing CAPTCHA. Invented a couple of decades ago, CAPTCHA tries to protect against unwanted bots by presenting a challenge (e.g., reading distorted text) that humans should find easy and bots should find difficult. Unfortunately, cybercriminal use of AI has inverted this. Google did a study a few years ago and found that machine-learning based optical character recognition (OCR) technology could solve 99.8% of CAPTCHA challenges. This OCR, as well as other CAPTCHA-solving technology, is weaponized by cybercriminals who include it in their credential stuffing tools.

Cybercriminals can use AI in other ways too. AI technology has already been created to make cracking passwords faster, and machine learning can be used to identify good targets for attack, as well as to optimize cybercriminal supply chains and infrastructure. We see incredibly fast response times from cybercriminals, who can shut off and restart attacks with millions of transactions in a matter of minutes. They do this with a fully automated attack infrastructure, using the same DevOps techniques that are popular in the legitimate business world. This is no surprise, since running such a criminal system is similar to operating a major commercial website, and cybercrime-as-a-service is now a common business model. AI will be further infused throughout these applications over time to help them achieve greater scale and to make them harder to defend against.

So how can we protect against such automated attacks? The only viable answer is automated defenses on the other side. Heres what that evolution will look like as a progression:

Right now, the long tail of organizations are at level 1, but sophisticated organizations are typically somewhere between levels 3 and 4. In the future, most organizations will need to be at level 5. Getting there successfully across the industry requires companies to evolve past old thinking. Companies with the war for talent mindset of hiring huge security teams have started pivoting to also hire data scientists to build their own AI defenses. This might be a temporary phenomenon: While corporate anti-fraud teams have been using machine learning for more than a decade, the traditional information security industry has only flipped in the past five years from curmudgeonly cynicism about AI to excitement, so they might be over-correcting.

But hiring a large AI team is unlikely to be the right answer, just as you wouldnt hire a team of cryptographers. Such approaches will never reach the efficacy, scale, and reliability required to defend against constantly evolving cybercriminal attacks. Instead, the best answer is to insist that the security products you use integrate with your organizational data to be able to do more with AI. Then you can hold vendors accountable for false positives and false negatives, and the other challenges of getting value from AI. After all, AI is not a silver bullet, and its not sufficient to simply be using AI for defense; it has to be effective.

The best way to hold vendors accountable for efficacy is by judging them based on ROI. One of the beneficial side effects of cybersecurity becoming more of an analytics and automation problem is that the performance of all parties can be more granularly measured. When defensive AI systems create false positives, customer complaints rise. When there are false negatives, ATOs increase. And there are many other intermediate metrics companies can track as cybercriminals iterate with their own AI-based tactics.

If youre surprised that the post-COVID Internet sounds like its going to be a Terminator-style battle of good AI vs. evil AI, I have good news and bad news. The bad news is, were already there to a large extent. For example, among major retail sites today, around 90% of login attempts typically come from cybercriminal tools.

But maybe thats the good news, too, since the world obviously hasnt fallen apart yet. This is because the industry is moving in the right direction, learning quickly, and many organizations already have effective AI-based defenses in place. But more work is required in terms of technology development, industry education, and practice. And we shouldnt forget that sheltering-in-place has given cybercriminals more time in front of their computers too.

Shuman Ghosemajumder is Global Head of AI at F5. He was previously CTO of Shape Security, which was acquired by F5 in 2020, and was Global Head of Product for Trust & Safety at Google.

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How AI will automate cybersecurity in the post-COVID world - VentureBeat