Rescuing civilization: Does the conservative/progressive rift pose an existential threat to humanity? – Resilience

Yes. A threat to civilization seems quite likely at this point and human extinction could even be in the cards. Renowned cosmologist Carl Sagan once suggested that our galaxy was teeming with planets, like Earth, capable of evolving advanced technological civilizations. To date, none have been detected. Reasons posited for this failure, from least to most likely, included: 1) no such other civilizations developed in the first place, or 2) we arent as good at detecting them as we once imagined, or 3) once those civilizations developed to the point they had the means to destroy themselves, they quickly and invariably did.

For 50 years I have tried to make adaptive sense of the rancorous bipolarity in the human species between conservatives and progressives. As an evolutionary human ecologist, conservatism makes little adaptive sense, certainly not in a fast-changing world. I regard it as regressivism. Yet, in virtually every large population free to openly express their political preferences, about half choose a conservative orientation and half favor a more progressive one.

From an evolutionary perspective, the inclination to be conservative or progressive appears randomly distributed, even within a family where one sibling will be progressive and the next conservative. Equally confounding, within each person both tendencies exist. Everybody has individualistic instincts serving the interests of me and mine, as well as communitarian instincts serving us and ours. Nature apparently hasnt seen fit to separate the two tendencies despite obvious potential for rancor and/or conflicting personal choices. Some political genius, however, decided it was a good idea to set us at each others throats. The two major political parties have separated us into opposing camps, demonizing the other, and uncompromisingly opposing any political position the other side takes, not the most enlightened social arrangement in human history. Extending this pastime from mere annoyance to open warfare, the most regressive U.S. administration in living memory is now spitefully dismantling the most important progressive advances of the past 120 years.

Since nature didnt distance us, we do it ourselves. We dont try to understand each others thinking, we watch different television channels, we socially isolate when possible, we dress in ways proudly identifiable as red neck or tree hugger, academic or suit, and we respond very differently to science, expert public health recommendations, conspiracy theories, and news from social media. We are even becoming reproductively isolated, somewhat akin to when Neanderthals and Homo sapiens lived in contact with one another for thousands of years, but rarely interbred. Eventually the Neanderthals, clinging to their old ways, died out on their own or were eliminated by their neighbors.

I have finally sorted this all out in a way that makes evolutionary sense. Social behaviors are not so much genetically instinctive as driven by learned cultural values ostensibly benefitting those important to us. Progressive values make perfect adaptive sense for the advancement of the human species and for civilization as a whole. Conservatism focuses its benefits primarily on self and a limited, select group of like-minded, religious, racial, or socio-economic cohorts. Given its innate distaste for innovation and its preference for ungoverned freedom, conservatism is counter-productive from the perspective of a social civilization, a regressive artifact of an earlier, billions-of-years-longer, more individualistic evolutionary stage.

From an evolutionary perspective, humans are a social species, a species that lives and functions most effectively, obligately, in communities, each individual with special interests and abilities, but coordinated by leadership and shared values in cooperative endeavors that benefit the community while still accommodating enough self-interest to make it personally satisfying. Our first responsibility is to our communities. Those communities, in turn, provide for our needs, individually and collectively.

But social species are the new kids on the evolutionary block, and were still struggling to get the social thing right. Individualistic, selfish instincts dominated life for most of its first four billion years. They remain deeply ingrained still. Communitarian values only began to creep into the human repertoire sometime after sexual reproduction evolved. They were well established by the time both parents were required to cooperate as a family to rear their young to independence. Over time, extending that cooperation, groups of families took advantage of living together in small social bands where they could share, care, and cooperate in food gathering and preparation, childcare, and mutual defense.

Progressive social values and behaviors have proven particularly adaptive in allowing us to experiment with new ways of progressing as a species. Cooperating as a group afforded people the comfort and protection to feel safe experimenting, for example, with new hunting areas, new prey, new technologies, and new ways to resolve the inevitable challenges of living amicably as a community. As we became more socially evolved, and as genetic and cultural predispositions toward communitarian values increased relative to primitive individualistic instincts, the willingness to experiment became more entrenched. Progressives are dependably more comfortable with experimentation, novelty, uncertainty, and risk-taking than are conservatives. Experimentation is the primary engine of social progress and adaptation to change, absolutely essential in todays world.

Over the last 200,000 years, our communities and social alliances have grown progressively larger and more complex. That trend has accelerated dramatically this past century, increasing the need to become even more socially adept under more challenging circumstances. These recent challenges include one never before encountered, an entirely novel evolutionary bottleneck. Reprising Carl Sagans concern, this one has the potential to end human history.

We managed to stumble and fumble our way until 50 years ago when the world was about as crowded with humans as it was reasonable to be. At that point, the global climate, its farmland and soils, its water resources, its minerals, its wildlife, its forests, its oceans, were fully subscribed and starting to be seriously compromised and depleted. The unprecedented size of our population had turned those individually essential natural resources into global common resources which had to be managed for equitable long-term sharing by all, lest those myriad people stuck with the short end of the stick, with little to lose, resort to violence to get their share. The COVID pandemic is an unsubtle reminder that we dont know if we have surpassed a survivable global population density, but thats another problem for another discussion.

If we dont quickly learn to simultaneously share and husband the worlds common resources while, just as challenging, learning to cooperate in ending world human population growth, we will end up competing to the death for resources that are essentially exhausted. Nobody will survive. We will embody Garrett Hardins Tragedy of the Commons.

Simultaneously husbanding and equitably sharing multiple global common resources is the ultimate social challenge to humanitys survival. Today specifically, that means navigating the impending perfect storm of simultaneous climate change, soil destruction, and fossil fuel depletion. Given the recent rancorous contention between conservatives and progressives over climate change alone, our social skills are apparently not up to managing multiple global commons. We could easily end up destroying any one of them in our social ineptitude or our stubborn selfishness and one is all it will take to end us.

If ever there were a time for more progressive, more experimental public policy it is now. We dont have time to wait for the gradual genetic dilution of regressive conservative instincts. We must make rapid, difficult, counter-instinctual behavioral changes now.

Progressives must lead through open-handed co-option. If progressives dont build bridges of trust and mutual respect to the conservative grass-roots of the world, relying on our many still-shared values to convince them of the need for dramatically greater social cooperation, any joint public policy effort will fail. This dilemma calls for the most creative diplomatic effort in human history, a concerted campaign to negotiate our mutual survival, progressive and conservative grass-roots alike working in harmony, forcing our leaders to follow our lead, the only rational approach to this novel evolutionary bottleneck.

What that negotiation or its resolution will look like is anybodys guess, but if we dont make the effort, and soon, we surely will fail. We already are failing. As things stand, the toxic progressive-conservative schism is the most glaring, counter-productive failure in human social evolutionary history. Given our unprecedented numbers, it is destroying both our environment and our democratic institutions, rendering our species increasingly ungovernable and, in due course, potentially extinct. We must learn a new way of living together.

Its time for a radically new, currently unimagined level of caring, sharing, and cooperating a global, colorblind just and equitable caring, sharing, and cooperating. Only progressivisms unequivocal commitment to a radically equitable, peaceful, and just sharing of the worlds common resources will convince the worlds conservatives to be part of any such negotiation. I think its fair to say that, on the whole, women have more of the needed social skills than men. I suggest that progressive women should take the lead in a civilization-rescuing global social revolution, starting with building an essential bridge of trust and mutual respect between progressive and conservative grass-roots everywhere in the world, in hopes of surviving this evolutionary bottleneck. With luck, Americas congressional elections of 2018 and the upcoming presidential election of 2020 will prove harbingers of a more progressive, more social, perhaps even more matriarchal, future for civilization. Given the misogyny of the current administration, that would be a delicious irony. Delightfully encouraging, to my mind.

Teaser photo credit: By Alborzagros File:Nations Gate palace (kakh-e-darvaz-e-keshvarha) in Persepolis.tif (edited version), CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=45347465

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Rescuing civilization: Does the conservative/progressive rift pose an existential threat to humanity? - Resilience

Link between early menopause and osteoporosis – The New Indian Express

Express News Service

Osteoporosis, termed as a silent disease as its effects are not often seen at an early stage, affects women more than men. Further, women with an early menopause have a 56 per cent increased risk of osteoporosis at a later age (in the 70s). They are four times more affected by early bone loss as compared to men, say doctors. As women age, the level of estrogen (primary female hormone responsible for bone health) further decreases.

The decrease begins in the perimenopausal (transition period) stage and is greater after menopause. As a result, there is an increased bone loss that makes women more prone to osteoporosis.While all women experience a drop in bone density when they go through menopause, those with an early menopause have more chances of developing weak and brittle bones as compared to those who have a late menopause. If we go by the age, women with menopause before 47 years have more than 50 per cent increased risk of osteoporosis in their late 70s as compared to a risk of 30 per cent in women with late menopause.

During the menopausal transition period (perimenopause), the average reduction in bone mineral density (BMD) is about 10 per cent. About 25 per cent of postmenopausal women can be classified as fast bone losers, says Dr Meenakshi Banerjee, Senior Consultant, Gynaecologist & Obstetrician, Madhukar Rainbow Childrens Hospital, Delhi.

What causes early menopause?

Multiple reasons: Smoking, lack of physical exercise or less exposure to sun, consumption of steroids even if warranted by other health conditions, all these contribute towards menopause. Very thin women too face the risk of an early menopause. However, early menopause can sometimes be caused by genetic factors. Premature ovarian failure also leads to an early menopause. Sometime ovaries have to be removed due to a medical condition or malignancy. This can also cause an early menopause, says Gynaecologist & Obstetrician, Dr Neha Khandelwal.

The way out?

Exercise, sunshine and diet, can delay the onset of osteoporosis. Adopting a healthy lifestyle coupled with adding fresh fruits, veggies and herbs in daily diet helps too. So does a diet rich in dairy products. Women must include green leafy vegetables like spring greens, spinach, broccoli, baked beans, nuts (especially almonds), soya beans, sardines, salmon, nuts, dried beans and sunflower seeds in their diet. A simple way to increase Vitamin D (essential to bone health because it enables absorption of calcium and phosphorus) is sitting under the early morning sun for 20 minutes.

A healthy and balanced diet is fundamental to bone health because it supplies proteins, carbohydrates, fats, vitamins, minerals and other nutrients vital for tissue renewal and growth. Besides, walking and gentle aerobics are excellent for bone health as these promote the entry of calcium into the bone mass where it is used for improved strength and growth, says Dr Banerjee.

Otherhealth issues

It is not just osteoporosis that stares women in the eye with an early menopause, but a host of other health issues too. As per a 2020 study published on human reproduction, women who undergo premature menopause are almost three times more prone to physiological problems like diabetes, high blood pressure, heart disease, stroke, arthritis, asthma and breast cancer and mental issues like depression and anxiety.

Age and incomeIn India, menopause generally happens between 50 and 60 years while in the West, it is between 70 and 80 years. Globally, the incidence of premature menopause is one cent women while in India, the rate has risen to 1.5 per cent in the last two years. Also, the incidence of menopause at 50 in high socio-economic group is 25 per cent, while the figure is 65 per cent in women of low socio-economic group.

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Link between early menopause and osteoporosis - The New Indian Express

Top letters: Eagleton wouldn’t have supported Barrett; Hawley offended by religious, not racial, bigotry – STLtoday.com

In 2018, after a teen with a gun murdered 17 high schoolers in Parkland, Florida, my generation rose up. A high school junior at the time, I united with students from around St. Louis who were afraid we would be next. We demanded action from our elected representatives. However, instead of doing her job and standing up for her young constituents, Rep. Ann Wagner voted against universal background checks and continued to pocket donations from the National Rifle Association.

The majority of Americans support universal background checks, but Wagner chose to listen to her donors instead of her constituents. She gave weak, inadequate responses to the terrified students who contacted her, begging to keep guns out of our schools. We are still angry because lawmakers such as Wagner have failed us. My generation is traumatized because of corrupt, greedy and selfish politicians like her.

I am begging everyone to vote against Wagner on Nov. 3 because she will not listen to us, fight for us or protect us. My classmates and I were too young to vote in 2018, but we watched as Wagner sold our safety for political action committee donations, and we paid attention as she ignored our pleas for sensible gun reforms. Now we are about to vote in our first election, and she is going to hear loud and clear that we want new representation.

Maggie Hannick Webster Groves

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Top letters: Eagleton wouldn't have supported Barrett; Hawley offended by religious, not racial, bigotry - STLtoday.com

Why Americans May Have A Better Chance Of Getting Pregnant In Late Fall – BabyGaga

Although other factors such as seasons could be contributing to the spike in conception rates in late fall, some have attributed it to Valentine's Day

Research done by the Boston University School of Public Health (BUSPH) has shown that conception rates are high in November and early December in North America. Although other factors such as seasons could be contributing to the spike in conception rates in late fall, some have attributed it to the Valentine's Day romance. A study that was published in the Human Reproduction journal early this year indicates that most couples from the southern part of North America begin trying to get pregnant from September. Most of these couples would succeed in conceiving in November or early December.

RELATED:Foods That Can Actually Help With Conception

Lead author from BUSPH, Amelia Wesselink, says that although many studies have been done to determine seasonal patterns in births, they don't capture details such as when the couple began trying to conceive, how long they tried, or the gestation period. According to the published journal, Amelia and fellow researchers said that some factors such as employment schedules, comfort, and personal choice could affect the timing of pregnancy in many couples. For example, some women might try to avoid pregnancy during the hot season, while for others, it could be a personal preference to have a fall baby!

According to The Brink, the researchers studied data from 14,331 women who had been trying to get pregnant for not more than six months. Out of these, 5,827 were Canadian and American participants, while 8,504 were Danish participants. The studies observed and captured details of the participants every two months through detailed surveys until they fell pregnant or have struggled to conceive for 12 menstrual cycles. The study collected information such as intercourse frequency, menstruation pattern, diet, smoking, level of education, and even income.

Amelia said that after carefully studying the seasonal patterns when couples try to get pregnant, she and fellow researchers found that conception rates were high during late fall and low in the late spring. Couples from the southern part of North America had high odds of falling pregnant in late fall. The most likely reason is that they prefer to give birth in summer when workplaces are not busy, especially in the U.S. The study showed that North Americans had a 16% high chance of becoming pregnant in the fall compared to spring, while Danes had only an 8% chance of becoming pregnant in the fall. Denmark, Northern US States, and Canada's conception rates weren't affected by seasons.

There was no significant change in the outcome after controlling factors known to affect conception, such as intercourse frequency, smoking, sugar intake, and medication use. However, the study didn't point out why there was seasonal variation in fertility. Amelia said that the study was trying to look at the various hypotheses on factors that varied with seasons and how they affected fertility.

NEXT:Why It May Not Be A Great Idea To Conceive A Baby During Quarantine

Sources: sciencedaily.com, bu.edu, futurity.org.

U.S. Pregnancy Centers Now Offering Dangerous 'Abortion Reversal' Treatments

I have been a writer since 2012, and have enjoyed the journey thus far. When I am not busy writing like there's no tomorrow, I enjoy spending time with my three daughters and watching Netflix.

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Why Americans May Have A Better Chance Of Getting Pregnant In Late Fall - BabyGaga

Early Menopause And Osteoporosis: Know The Risks – Femina

Every woman goes through menopause. When it happens depends on the womans medical condition and lifestyle changes. According to a survey conducted a few years before by the Indian Menopause Society, the average age of menopause of an Indian woman is 46.2 years much less than their Western counterparts (51 years). There was a correlation between the age of menopause and social and economic status, married status, and parity status.

Women who have early menopause have 56 per cent increased risk of osteoporosis in their 70s according to a study held by Oxford Universitys publication Human Reproduction. The study claims that women who undergo premature menopause are almost three times more likely to develop osteoporosis as also other multiple, chronic medical problems including diabetes, high blood pressure, heart disease, stroke, arthritis, asthma, depression, anxiety or breast cancer.

Understanding The Causes

Dr Meenakshi Banerjee, Senior Consultant, Obstetrics and Gynaecology, Madhukar Rainbow Childrens Hospital, Delhi, gives her insight into this. It has been observed that during the menopausal transition period (perimenopause), the average reduction in bone mineral density (BMD) is about 10 per cent. About 25 per cent of post-menopausal women can be classified as fast bone losers, and this can be increased by various other factors like genetic influence, medicine effects like steroids, anti-estrogen medications, low exercise and activity among others.

Her colleague, Dr Neha Khandelwal, Senior Consultant, Obstetrics and Gynaecology, notes that there are various reasons of early menopause which can be genetic, Even premature ovarian failure, in which ovaries which are responsible for producing female hormones fails to produce adequate hormones, leads to early menopause. Removal of ovaries due to any pathology, malignancy can cause early menopause.

Osteoporosis is also termed as a silent disease as its effects are not seen in the early stages. Women are four times more affected by early bone loss as compared to men. Estrogen, which is a primarily female hormone, is responsible for bone health. After menopause and in the peri-menopause there is an increased bone loss due to decreasing estrogen levels hence making the women more prone for osteoporosis, adds Dr Banerjee.

The other factors affecting estrogen levels can also be related to women being on antiestrogen medications (given in breast cancer treatment), women who are on steroid medications for more than three months.

Preventive And Curative Solutions

A womans susceptibility to osteoporosis increases with reduced exercise, activity, low BMI and increased smoking and alcohol. Over time, the bones become weak because of poor lifestyle choices such as smoking, drinking alcohol or eating junk food. Adopting a healthy lifestyle coupled with adding fresh fruit and herbs in your daily diet can help to overcome the disorder, the good doctors both feel.

Walking and gentle aerobics are excellent for bone health because they promote the entry of calcium into the bone mass where it is used for improved strength and growth. A healthy and balanced diet is fundamental to bone (and general) health because it supplies the protein, carbohydrate and fat, vitamins, minerals and other nutrients vital for tissue renewal and growth, advises Dr Banerjee.

Image: 123rf

Fresh fruit and vegetables supply a vast range of essential minerals and other nutrients needed to maintain a sturdy skeleton. Your diet should also include dairy foods and foods rich in calcium, like green leafy vegetables, spring greens, spinach and broccoli, baked beans, nuts (almonds), soya beans, sardines, salmon, nuts, dried beans, and sunflower seeds.

Vitamin D is also essential because it enables calcium and phosphorus to be used to form strong bones and teeth. It can be obtained from early-morning sunshine and as a supplement. Such patients should expose their body to sunlight for 20 minutes/day from May to October. It can also be obtained from food, e.g. milk and dairy products, fish liver oils, sardines, herring, salmon, and tuna.

There is something that can help to reduce the loss of bone and other postmenopausal symptoms like vaginal dryness and hot flushes. Hormone replacement therapy in the form of estrogen is a what can be undertaken to overcome the problem, but like any other therapy, the woman needs to take utmost caution and proper screening should be done beforehand to analyse how the therapy can work for her.

Dr Khandelwal shares, Hormonal therapy can be taken in the form of tablets, skin patches, estrogen gel and implants. Cyclical HRT can be taken with daily estrogen and progesterone alongside for the last 14 days of the cycle. This is for women with menopausal symptoms. For post-menopausal women, continuous combined HRT should be considered without breaks.

Also Read: 4 Reasons For An Early Menopause

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Early Menopause And Osteoporosis: Know The Risks - Femina

Keanu Reeves goes back to the ’90s with a shaved head – Somag News

Actor Keanu Reeves said goodbye to his dark hair and now has a new image that is making fans even more in love.

Keanu Reeves looks unrecognizable after shaving off his signature long hair and debuting with a striking haircut. In more recent years, the John Wick actor has become more recognizable for his shoulder-length dark locks.

However, it is not a completely new hairstyle for the star of The Matrix 4, who has previously styled various styles during his time in Hollywood.

Of course, his latest hair transformation is for a role in a movie. Keanu, 56, shaved off his dark hair to reprise his role as Neo in the latest installment of the Matrix franchise.

The main star has been filming in locations in Berlin, Germany, for four months as cameras began filming again amid the coronavirus pandemic.

Fans will note that his latest look has similarities like when his iconic character Neo wakes up in a human reproduction facility in the 1999 film.

Keanu first showed off his new look while saying goodbye to his stunning girlfriend Alexandra Grant, who had accompanied him to the hotel in a car.

The actor was camera shy as he ran his fingers through his freshly cut hair. Temperatures were cool in Berlin so the Canadian stayed wrapped in several layers for his departure. Keanu was traveling light with a backpack over his shoulder and a red bag.

Matrix 4 will hit theaters in 2021. Filming has been hampered by delays amid the coronavirus pandemic that sent shockwaves through the entertainment industry.

The filming scenes had to stop in March when the killer virus shook the world to the core.

The lead stars began returning to Germany to be on location for filming in June. Carrie-Ann Moss has returned to her role as Trinity from the original trilogy. Jada Pinkett-Smith also reprized her role as Niobe for the fourth film.

https://www.instagram.com/p/CG0i-D_jfgs/?utm_source=ig_embed

As we informed you in Somagnews in the romance department, Keanu has been happily loved by his girlfriend Alexandra.

The couple loved the show business circuit when they went public with their relationship in November of last year. It is not known how long they have been romantically together, but their close relationship dates back years.

They met when they collaborated on the adult picture book Ode to Happiness in 2011. The rest is history. Do you like the way Keanu looks in his new style?

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Keanu Reeves goes back to the '90s with a shaved head - Somag News

The Goodness Paradox: The Strange Relationship Between Virtue and Violence in Human Evolution – The Humanist

BY RICHARD WRANGHAMVINTAGE BOOKS, 2019

Already in the preface, Richard Wranghams The Goodness Paradox put a smile on my face. Wrangham there advocates the position that humans are naturally capable of both good and bad. In my own philosophical-naturalist musings, Ive always operated from that principle, so evident in history its distressing that so many evolutionary biologists, not to mention humanists, have taken the position that humans are inherently one or the other.

Wrangham sets out his strongest case on this divisive issue at a scientific level. His extensive parsing of the latest research is crucial. He, too, starts out by citing notorious examples of human goodness and badness, including in the same person, concluding emphatically, The potential for good and evil occurs in every individual.

Humanists will appreciate that Wrangham carefully considers methodological issues before diving into the evidence. The value of research on primate behavior to assessing human evolution is highly debated. Even human variation raises the question of whether there is a human nature at all. Throughout, he questions research results to distinguish what is solely characteristic of other species and what can be analogized to humans.

Central to his substantive argument is the distinction between two types of aggression or tendency toward violence. One type is reactive, the other is proactive. Studies show that different species of hominines and certain other animals display different ranges of aggressiveness of each type.

Reactive aggression is the spontaneous response to threat or provocation. Humans have relatively less reactive aggression than primates. Proactive aggression is planned and deliberate, typically, but not always manifesting in tribal, civil, and international war. Humans are particularly aggressive in this proactive sense, exhibiting a far more butcherous aggression in war than primates. Of course, that proactive aggression is directed at other groups of humans. That said, some individual and groups of humans are naturally more proactively aggressive than others.

Wrangham cites a great example to illustrate the difference between reactive and proactive aggression:

The anthropologist [Sarah] Hrdy noted that to pack hundreds of chimpanzees into close quarters on an airplane would be to invite violent chaos, whereas most human passengers behave sedately even when they are crowded. As Dale Peterson observed, however, intense screening is needed to ensure that a secret enemy will not carry a bomb on board. The contrast illustrates the difference between our low propensity for reactive aggression and our high propensity for proactive aggression.

Critically, the early evidence suggests there is indeed no genetic connection between propensity for reactive and proactive types of aggressiveness. Human domestication of other animals shows that reactive aggressiveness in a species can be reduced without affecting the proactive aggressiveness of the species. Housecats, for example, are comfortable with humans but retain their instincts for killing for food and fighting for territory.

Wrangham argues that because humans have low propensity for reactive violence, they were domesticated. Implicitly, he equates low propensity for reactive violence with domestication, although one can quibble with the label. He covers the history of the idea of humans as having been domesticated, including how the concept was twisted into eugenics and Nazi views of Aryan superiority.

But the big question is, who domesticated humans? Wrangham disregards supernatural explanations in favor of the assertion that humans self-domesticated. Like a good naturalist, he examines the evidence. Evidence concerning domestication of other animals by humans shows that certain anatomical changes come with domestication. Compared with their wild cousins, they become smaller in stature, have smaller teeth, show less size difference between male and female, and have smaller brains. These changes are called the domestication syndrome. He then identifies similar changes in Homo sapiens between about 30,000 and 12,000 years ago. Wrangham argues this time period is when humans self-domesticated.

That framework calls for an explanation of how humans self-domesticated. He begins exploring that question by acknowledging that domestication is an inapt term, because it implies that a domesticator is necessary. He covers the evidence that a number of non-human animal species that could not have come from a domesticator in fact exhibit a low reactive propensity for violence. The best example is bonobos, who have a common ancestor with chimpanzees. Their genetic lines diverged between nine hundred thousand and 2.1 million years ago. Now, bonobos in the wild engage in little reactive violence, while wild chimpanzees exhibit a lot of behavior in that category. Bonobos and Homo sapiens have characteristics associated with the domestication syndrome; chimpanzees do not.

The idea that humans have self-domesticated is, in turn, central to Wranghams thesis about the evolution of goodness. He cites reams of scientific studies showing that humans in hunter-gatherer societies tend to have moral standards that, as I read it, require either family or group elders of socially disruptive individuals to impose what he calls capital punishment. Capital punishment is central to Wranghams construct of how humans self-domesticated: small groups of humans devised social norms and mechanisms to kill individuals who engaged in excessive reactive violence against members of their own tribe. In the process, they cut violent humans out of the breeding pool over thousands of years.

Reading this, I realized for the first time that imprisonment and judicially ordered capital punishment (now mostly discredited) in contemporary society inherently restricts the reproduction of offenders deemed violent and anti-social. It puts the systemic racist bias of the US criminal justice system against racial minorities, especially Black men, in a new, even more pernicious light.

Wrangham argues that the reduced tendency for reactive violence, however it came about, was accompanied by increased in-group tolerance. Indeed, human infants generally recognize fairness and approve punishing those who are unfair. That corresponded to the development of codes of conduct for behavior toward group members.

Specifically, Wrangham points to evidence that mostly only males benefited from self-domestication. The reduction in reactive violence enabled men to cooperate against the alpha male. Collaborative men in the group replaced the dominance of the reactively violent alpha male with a democratic sharing of power among themselves. In my research, this is borne out by evidence of possibly the earliest account of democracy occurring among warriors in ancient Babylon deciding collectively nearly 5,000 years ago whether to wage war against a neighboring tribe. However, women and children, not to mention men who violated the norms established by the male control group, were subservient.

As with my example from Babylon, Wrangham sets a larger context of existing hunter-gathering humans in which human males and, at times, females apply a moral code that can include killing of socially unacceptable individuals. He asserts an ambitious agenda of showing that killing specifically resulted in the domestication of humans. In the end, the course of his argument relies on a broader level of social enforcement of moral codes through various means that include execution. I will leave to the individual reader to conclude whether the evidence Wrangham cites is sufficient to that cause.

The clear control by cooperative males of the rest of human society enabled greater group power and cohesion. Language was a hugely valuable new trait that enhanced the establishment of group norms and their enforcement. Enforced conformity allied with more lethal killing ability that came with new weapons and the tactical advantage of language empowered humans to exterminate hominine competitors. Naturally, the troubling legacy of that power is the savagery of internecine warfare in the common era.

Indeed, Wrangham argues that occasionally human societies have failed to control their most aggressive members. When they have gained control of the structures of modern societies, they have instigated conflict with cataclysmic consequences. In the era of President Donald Trumps reactive and proactive aggressiveness, the book has its most profound implications. As much as the republican form of government in the US has led to consolidation of power to the benefit of the rich, it has generally precluded highly aggressive individuals from becoming president. However, the pluralistic reorganization of the two-party system has allowed someone like Trump to be nominated and, against a candidate unprepared to deal with his aggressiveness, win the most powerful position in the world.

Wranghams words of wisdom bear witness to our present circumstances: To avert episodes of violence we should constantly remind ourselves of how easily a complex social organization can decay, and how hard it is to construct. Just as Thomas Jefferson advocated a revolution every twenty years, all peace-loving, egalitarian people must collaborate to challenge highly aggressive individuals who would undermine cohesion and tolerance to the detriment of the greater good.

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The Goodness Paradox: The Strange Relationship Between Virtue and Violence in Human Evolution - The Humanist

What Can We Learn From Fear This COVID Halloween? – zocalopublicsquare.org

Take it from an evolutionary biologist: This Halloween, we need to embrace our fears. Courtesy of John Nacion/Associated Press.

by Daniel T. Blumstein|October28,2020

Its Halloween, the season when we go out and try to spook each otherat least in normal years. Indeed, fears of contracting and spreading the novel coronavirus have drastically impacted many of our Halloween plans. Should they? And more importantly, how do our fears impact our behavior to make us safe? Im a biologist who studies animal behaviorincluding what scares creatures ranging from giant clams and other immobile marine invertebrates to a variety of birds and mammals, and why. Animals responses to frightening thingsreactions that have helped species survive over millions of yearscan help explain our own reactions to this global pandemic, and may suggest the best path for us to follow in these uncertain times.

Because animals face predatory risks that cant be fully eliminated, its essential that they learn to live with fear, and develop strategies to respond correctly. Overcompensate, you miss out on resources and may starve. Undercompensate, a predator abruptly ends your life. For instance, the animals I studymarmotsflee to the safety of their burrows when a coyote is around. But how long should they remain hidden away, unable to find food? Life is about managing tradeoffs. So when does, and how should, fear motivate change?

In humans, fear motivates change best when the threat is simple to understand, actions have a direct impact on the outcome, and the potential outcome is viscerally repulsive; disgust is a powerful motivator. Consider public health officials campaigns against methamphetamine abuse in the early 2000s. Because meth is so highly addictive, informational campaigns had limited success. Enter Tom Siebel, a software millionaire on a mission with a brilliant idea: Instead of peppering users with statistics, show them pictures of meth-mouth, the severe dental decay associated with meth abuse. Starting in 2005, Siebel paid for highway billboards in Montana that showed close-ups of a womans face with rotten teeth with text that read: YOULL NEVER WORRY ABOUT LIPSTICK ON YOUR TEETH AGAIN. He continued his fear- and disgust-driven campaign with a series of short television and internet commercials that showed unsuspecting users their horrible futures. The campaign worked. High school meth use went down 45 percent in two years, compared to an average of just 7.8 percent annually previously.

Fear most successfully leads to immediate responses. It doesnt work as an agent of change over longer periods, because animals habituatethey stop responding to non-threatening stimuli over time. Indeed, designing habituation-proof stimuli to scare away problem animals and reduce human-wildlife conflict is a compelling challenge. The plastic owl above the outdoor urban park dining area works at deterring pigeon traffic for a just few days before the birds realize its harmless and start appreciating its utility as an object that helps protect them from the wind. People tend to tune out, too. In the aftermath of 9/11, the Department of Homeland Security began estimating terrorism threat levels and communicating them to the American public. The color-coded system reported elevated red or orange levels of risk over an extended period of months. An analysis I did showed that the unchanging high threat levels produced the opposite of the desired responsepeople stopped seeking out information on how to prepare for terrorist threats. Americans habituated to the governments warnings. Were experiencing habituation to warnings about coronavirus threats now.

There are other costs to maintaining a fearful state for too long. For snowshoe hares, the mere exposure to predators, or predatory cues, can increase production of stress hormones and shift individuals into survival mode, directing energy away from growth and reproduction and toward defense. Snowshoe hare populations increase and decrease over time, driven by the population of their main predator, the lynx. As lynx populations increase, hare populations decrease until there are not enough hares to feed the lynx, resulting in a dramatic crash of the lynx population and a rebound for the hares. Researchers have found that hares have higher stress hormone levels at the peak of the lynx population cycle. In another study, the mere proximity of a dog walking by an enclosure containing pregnant female hares resulted in higher stress hormone levels in the dams and their offspring. Importantly, stressed dams produced fewer offspring. In a follow-up study, researchers found that the effects of stress hormones on reproductive success persisted through generations: The offspring of stressed mothers themselves were relatively more stressed and had fewer babies.

In humans, fear motivates change best when the threat is simple to understand, actions have a direct impact on the outcome, and the potential outcome is viscerally repulsive; disgust is a powerful motivator.

Complex problems are, in part, so defined because causality isnt obvious. Solving complex problems requires something more than the simple, direct, fear-based motivators we see in the animal world. This is certainly true of the pandemic. As we learn more about it, we may think we are better able to manage the risks were exposed to. To some extent we are. The risk of transmission and infection is reduced by wearing masks, physically distancing, and minimizing time spent in closed spaces with others. However, none of these actions totally eliminates the risk of getting infectedwhich makes giving up on any one of them very tempting.

When passive restraint systems like airbags in cars were first introduced, some people stopped putting on their seat belts because they assumed that they would be safe. In reality, it takes both tools together to increase your odds of surviving a bad accident by keeping you in the car, where you typically are safer. Studies of taxi drivers showed that they drove faster on wet surfaces when antilock brakes were first introduced because they could do so and still arrive reasonably safely, shaving precious driving minutes off each ride. However, driving faster on wet streets, even with anti-lock brake technology, is never a great idea: There was no net reduction in car accidents.

Marmots vary in how fast they can run away from threats. It turns out that marmots who are slower than average spend relatively less time looking around when they are foraging. By doing so they reduce the time they are away from the safety of their burrows, thus compensating for risk. But another way to view this variation is that animals who are better able to escape spend more time looking around while foraging and thus increase their exposure to risk. Perhaps marmots, like taxi drivers, accept a certain level of risk when the possibility of reward beckons.

At a very immediate level, our sadness at losing the chance to scare one another this Halloween could reflect our belief that we are in control of our risk of infection. And this has important insights for our response to a global pandemic. Responding to the pandemic is a marathon, not a sprint. It will require constant vigilance and behavioral changes for more than the foreseeable future. As new drugs and vaccines are introduced, we should be extra vigilant of our perceived safety. Risks are cumulative, and the more you accept, the greater the likelihood that they will eventually catch up to you. Tragically, this was a message illustrated by the recent outbreak in the White House, and at a macro level, by the recent spikes we are seeing worldwide. Protective measures that increase our perceptions of safety (in the White Houses case, rapid testing and everywhere else, the success of social distancing in the summer months) encourage us to take more risks and are thus, counterintuitively, risky.

Some people view the warnings about coronavirus as the boy who cried wolf. After all, they themselves have not gotten sick, and most people who get COVID-19 dont die. But this is the wrong way to interpret what we see around us. We all have different risks based on what we do, various pre-existing conditions, and our age. According to the CDC, if infected, I am at least four times more likely to be hospitalized and 30 times more likely to die than most of the undergraduates I teach. We know many people experience longer-lasting negative health effects from the virus. I also know that its not just my health at stake but also the health of others who may have even higher mortality risks. Taken together, this leads me to think that all of usmy students and myself includedare morally obligated to continue to take the coronavirus threat seriously.

Halloween illustrates the joy associated with celebrating our fears by allowing us to express one of our most primordial emotions. When we do so, we should embrace our fears and remember that we are descended from a long line of successful ancestors, dating back millions of years, who got their risk assessments right. They neither over-reacted, nor under-reacted to environmental threats; they figured out how to successfully live with them. I suggest that this Halloween we commit to making multimedia costumes that can scare, via Zoom, from afar. Meanwhile, lets look forward to a time, hopefully not too far in the future, where we are surrounded, in person, with scary costumes, boos, and screams of both fear and joy.

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What Can We Learn From Fear This COVID Halloween? - zocalopublicsquare.org

Reflections of a First-Year Buckeye: College visits, community safety, football plans, graduate student stipends – The Ohio State University News

President Kristina M. Johnson sent the following email to The Ohio State University community today (Oct. 27).

Dear Students, Faculty and Staff:

My college visits are a highlight of my first-year Buckeye experience. Learning from you where you study, teach, perform and practice is enlightening. I am particularly interested to see our universitys founding land-grant mission in action whether through teaching and learning, convergent research and scholarship, or outreach and engagement efforts.

I recently visited Moritz College of Law, where students, faculty and staff talked passionately about their commitment to building bridges that connect Ohio States expertise and experience with initiatives and programs that positively impact our communities. It was inspiring learning from students and faculty about their passion for public interest law. The college recently adopted a new Diversity, Equity, Inclusion and Justice strategic plan.

Additionally, Moritz has partnered with Ohio Governor Mike DeWine and others on an expedited pardon project.

University Task Force on Community Safety and Well-Being

Our new standing University Task Force on Community Safety and Well- Being held its first meetings last week with a charge to deliver an initial report by mid-November. A full list of task force members is now available on the just-launched task force webpage. The webpage provides a form for sharing ideas and suggestions to improve the safety and well-being of our community. I encourage you to participate.

As we are focused on safety, here are some updates on resources offered through the university:

Return to fall sports

It was so great to see our football team in the Shoe on Saturday in their big win against Nebraska, 52-14. I was honored to accept the Game Ball from our outstanding student-athletes and coaches after the game!

We look forward to the day soon when all of our student-athletes will return safely to competition. Thank you to all of our students, faculty, staff and fans who wore masks, practiced physical distancing and celebrated from home.

While this Saturdays football game is at Penn State, we all need to remember that Every Game is a Home Game.

This weekend, we will be hosting a range of Buckeye Bash opportunities for students to watch the Ohio State vs. Penn State game (masked and physically distanced) at spaces on campus. Living in a residence hall means the entire campus is your home, and we want you to continue to homegate safely and responsibly.

The Ohio Union, for example, will show the game on all screens in the building. Food, special giveaways and cant-miss prizes (including passes for Ohio Stadium tours, football jerseys and more) will be highlights of the day. Details on these and additional programs will be shared throughout the week. Additionally, all members of Buckeye Nation will be able to play along virtually, wherever they are in the world.

Stay safe. Have fun. Go Buckeyes!

COVID-19 updates

The seven-day average positivity rate for all students is at .88%. On campus, the seven-day average rate is .64% while the off-campus rate is 1.25%. We have expanded our testing efforts to approximately 18,000 each week, and have conducted more than 165,000 tests overall.

Last week, Ohio States Comprehensive Monitoring Team issued its initial report on ongoing data analysis designed to stem the spread of infection. The report observed that the reproduction number (Rt) has remained stable, primarily below 1, which is an indicator that the epidemic may be slowing.

Also, two key measures declined and then remained stable since mid- September:

1) Trends in infection rates among asymptomatic students, and 2)Positive rates among students who get tested because they are experiencing symptoms or have come into close contact with someone who is infected.

The team, led by Dr. Amy Fairchild, dean of our College of Public Health, has urged caution as the weather turns colder and stressed the importance of remaining vigilant by wearing masks, staying 6 feet apart and following all of our Safe and Healthy Buckeyes requirements.

Racial justice, diversity and inclusion

As the work of our Task Force on Racism and Racial Inequities progresses, I joined co-chairs Dr. James L. Moore III and Dr. Tom Gregoire, as well as Alumni Association President and CEO Molly Ranz Calhoun, for the first in the four-part webinar series Ripe for Change: Conversations on Race in America. You can watch the full discussion here. Over 700 people registered for the virtual event, and I continue to be impressed by the depth of commitment in our community to addressing this critical challenge. One of the topics we discussed is how to leverage and scale up high-impact mentorship programs such as Young Scholars, LASER and others. To register for future webinars, visit the Office of Diversity and Inclusion webpage.

The task force continues to collect data from members of the university community for its report, and I look forward to sharing more in the coming weeks.

Voting reminder

The November 3 general election is next week, and we encourage all Buckeyes to exercise their right to vote. Early voting in Ohio continuesthrough November 2. You can find your countys early voting center location and hours at voteohio.gov. For more voting resources, visit OSU Votes.

Discovery, learning and impact

Each week brings incredible examples of your impact on our campuses and in our communities.

The Master of Sport Management Degree in the College of Education and Human Ecology is one of only two such academic programs in the nation that has closed the gender gap, with 50% or more of its enrolled students and faculty being female.

Dr. Rattan Lal, on the same day he received the 50th annual World Food Prize, was honored by the university and our College of Food, Agricultural, and Environmental Sciences with the naming of the CFAES Rattan Lal Center for Carbon Management and Sequestration.

Leaders from our College of Optometry have been named American Academy of Optometry 2020 Award recipients.

Dr. Melissa Shivers, vice president for student life, has been elected to a two- year term on the national board of the Association of Fraternity/Sorority Advisors, beginning in 2021.

Ohio States University Hospital, Ross Heart Hospital, Brain and Spine Hospital and Dodd Rehabilitation Hospital each earned a fourth consecutive Magnet designation by the American Nurses Credentialing Center. The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute also has Magnet status, which is the highest recognition a hospital can receive for outstanding nursing performance.

Graduate student stipends

We were pleased to share last week that the university will increase the minimum stipend for teaching, research and other graduate associates by$4,000 over the next two years. With these increases, Ohio States minimum stipend is projected to rise from the bottom half of the Big Ten to among thetop third.

Based on current figures, the universitys 2021-22 ranking would be fourth in the Big Ten. This represents an investment both in our graduate students and in Ohio States academic mission. As many of you know, graduate associates teach classes, pursue important research and scholarship, and support the university while working to earn advanced degrees. Their contributions to and roles in our university community are vital.

Thank you for all that you do, Buckeyes. Sincerely yours,

Kristina M. Johnson, PhD

President

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Reflections of a First-Year Buckeye: College visits, community safety, football plans, graduate student stipends - The Ohio State University News

UC Berkeley is Disavowing its Eugenic Research Fund after Bioethicist and Other Faculty Call it Out – History News Network (HNN)

In late 2018, UC Berkeley bioethics professor Osagie K. Obasogie received a campus email about a research fund available to faculty members in the School of Public Health.

He was stunned by what he read.

The Genealogical Eugenic Institute Fund, the email said, supports research and education in eugenics a field discredited after World War II as a horrifying ideology that sought to use science to improve the human race by promoting traits deemed superior and breeding out those judged undesirable. The judgments aligned strongly with social biases that favored white, able-bodied and financially stable people.

Eugenics was used as a justification for Hitlers Nazi Germany to kill 6 million Jewish people, and U.S. authorities to forcibly sterilize more than 60,000 people in California and more than 30 other states largely in the early 20th century.

But Berkeleys eugenic research fund has been very much active.

The $2.4-million fund was offering an annual payout of about $70,000 in fiscal year 2020 to support research and education on policies, practices and technologies that could affect the distribution of traits in the human race, including those related to family planning, infertility, assisted reproduction technologies, prenatal screening, abortion, gene editing and gene modification, the email said. That modern definition of eugenics included perspectives that shed light on not only the benefits but also the limitations and the ethics of these alternative approaches to improving the human race.

I was shocked and dismayed, Obasogie told the Los Angeles Times. He, along with a small group of faculty, raised their concerns with the emails author, a former senior administrator.

Those alarm bells prompted the school to freeze the fund and launch a review into how the university could have accepted such a gift in its modern past it came from a family trust to the University of California Board of Regents in 1975 for research under the banner of a now-reviled ideology.

....

But Berkeleys eugenic research fund highlights a reality that Obasogie and other ethicists say is insufficiently discussed: Eugenic thinking did not disappear after the horrors of the Holocaust were revealed. In some ways, it remains embedded in medicine and public health today.

In the United States, government and medical authorities no longer promote eugenics through laws allowing forced sterilization, for instance, or barring marriages with the feeble-minded or between races. About 20,000 people disproportionately nonwhite and poor in California institutions were sterilized under the state eugenic law, which was enacted in 1909 and repealed in 1979.

But the development of reproductive and genetic technologies today allows individuals to make some limited choices about what kinds of humans they deem most desirable and should be selected to live, said Alexandra Minna Stern, a University of Michigan expert on eugenics.

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UC Berkeley is Disavowing its Eugenic Research Fund after Bioethicist and Other Faculty Call it Out - History News Network (HNN)

Continental Plays with the Future of Car Audio – Car and Driver

Immersive sound is the siren song of car audio makers, luring customers not to their deaths but to the options list. Audi offers Bang & Olufsen's 3D Premium Sound System, Mercedes rocks Burmester's high-end 3D surround-sound system, Range Rover's Meridien promises 3D in-car surround sound. Bose has been pitching surround sound since 1996, after making its first factory-installed audio system for the 1983 Cadillac Seville.

Recreating the preternatural, submersing acoustics of a medieval cathedral these days requires a bouquet of speakers and a lot of power. The Bowers & Wilkins system in the Maserati Levante can put out 1280 watts through 17 speakers. The NAIM unit in a Bentley Flying Spur dishes out 2200 watts through 21 speakers. The Revel Ultima 3D system puts 28 speakers and 1200 watts inside the Lincoln Aviator. The 2021 Cadillac Escalade's Platinum trim comes with a 36-speaker AKG Studio Reference system.

Manufacturers could keep adding speakers until there's no room left in the vehicle, or maybe the next step is the approach Continental Automotive is taking. With its Ac2ated technology, the German supplier best known for tires turns the vehicle into a speaker, a process that could save weight, energy, space, and change the way designers approach the vehicle's cockpit.

Ac2ated uses what are called actuators (hence the name) or exciters. An actuator is a small, puck-like cylinder that has an active surface capable of high-frequency vibrations. "We are putting an exciter on a surface in a vehicle," Continental's innovation and Human Machine Interface expert, Susan Drescher, said, "and giving it a very slight vibration to create a sound from that surface so that your car's pieces become the speaker, as opposed to having speakers installed in the car."

The principle is the same one employed by violins or acoustic guitars, where strings send vibrations resonating through the instrument. The science works on glass and plastic, too. The result, according to Continental, makes vehicle occupants "feel as if they are sitting in a concert hall surrounded by sound."

The technology isn't rare. Amazon sells Dayton Audio exciters for $20, and companies like Solid Drive make systems for home and office use. The tech isn't new, either. Freedom Drivers hit the market in 2007, and in 2013 United States auto industry supplier Johnson Controls produced an excellent behind-the-scenes video of its Lightweight Overhead Audio System with help from studio engineer Tony Bongiovi (Jon Bon Jovi's second cousin).

Continental first showed Ac2ated at the Consumer Electronics Show in 2018. At CES 2020, Continental announced a partnership with Sennheiser that paired Ac2ated with Sennheiser's AMBEO 3D technology. AMBEO provides algorithms that enhance the digital source signals, spreading sound throughout the vehicle with improved spatial reproduction and fidelity.

Because the actuators live in the vehicle's structure like traditional speakers, implementing Ac2ated properly requires working with an automaker as the vehicle is being designed, a relationship like the collaboration between Rolls-Royce and its Bespoke Audio producer for the Phantom II.

Continental says that A-pillars are generally a good place for exciters to produce high frequencies, the door panels are suitable for midrange, and the headliner and rear shelf work best for bass. However, an actuator can be placed almost anywhere, with stiffer materials working better than softer materials. "We work very early on [asking an OEM]," Drescher said, "what are you covering the surfaces in, how much air space is in that surface because you need some air space, so you're not going to pack padding around it."

After the actuators are placed, Continental and Sennheiser fine tune the system. Ac2ated's dynamic range covers the spectrum of human hearing, from 20 Hz to 20 kHz and beyond. The system can be programmed with the same noise-cancellation features as today's systems. And audiophiles retain control of bass, treble, balance, and fadereverything they're used to controlling.

Ac2ated's primary benefit isn't in replacing traditional sound reproduction, however. The most important advantages are saving weight and space, freeing up design, and conserving energy.

According to Continental, a conventional high-end audio system uses between 10 and 20 speakerseven the Dodge Charger can be optioned with 19 speakersand weighs up to 33 pounds, taking up a total volume from 0.4 to 1 cubic foot. Drescher said Ac2ated's tweeters and midrange units aren't much smaller than traditional speakers, but the bass unit is substantially smaller, and the subwoofer doesn't require an enclosure "because your car is the box." The Ac2ated system requires fewer pieces, she said, "maybe 13 as opposed to 20 speakers" producing 12-channel audio. Compared to the traditional speaker array, a high-end Ac2ated system might weigh about two pounds and takes up 0.04 cubic feet. The weight savings help all cars but electric cars especially. That Ac2ated draws less energy and that the system is less expensive than traditional speakers doesn't hurt, either. And Continental is working on exterior sounds for electric vehicles where the sheetmetal would become the instrument.

Since we've all pulled up next to that car with the 22-inch subwoofer that rocks the neighborhood, we wondered: How does Ac2ated keep from vibrating a car to death? "It's not that kind of shake," Drescher said. The vibrations are barely detectable.

How soon will this future arrive? Drescher told us Continental is currently working with an OEM. Which one? She wouldn't say. It's a big secret. But by tweaking how we listen, Continental could help revolutionize the look and feel of the cockpit. Without the need for speaker grilles scattered about, designers get more freedom. "It's a huge change for future interiors," Dresher said. "We see these more clean, simple, minimal types of interiors coming."

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Continental Plays with the Future of Car Audio - Car and Driver

Moving from rhetoric to action: how Africa can use scientific evidence to halt the COVID-19 pandemic – Infectious Diseases of Poverty – BioMed Central

The ongoing pandemic of the coronavirus disease 2019 (COVID-19) has severely impacted global health, economy and politics in different patterns in various continents. The disease which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a public health event of international concern on 30th January 2020 [1] and a pandemic on 11th March 2020 [2]. As of 10th August 2020, 19462112 confirmed cases and 722285 deaths of the disease had been reported from all countries, areas and territories of the world [3]. Africa reported its first case in Egypt on 14th February 2020 through an importation and by 10th August 2020, all 54 African countries had reported 1035932 confirmed cases and 22920 deaths [4, 5]. Local community transmission has been established in most of these African countries. While Africa remains oneof the least affected regions, recent developments and data from within the continent and other regions particularly Europe and America show that the numbers of cases and deaths can grow exponentially and overwhelm even the best of systems in a relatively short time if effective prevention and control measures are not instituted on time [6, 7].

The fear, anxiety and panic induced by the rapid spread of the pandemic prompted several African countries to take drastic actions some of which are not necessarily based on scientific evidence. Some countries closed their air, sea and land borders and imposed total national or partial sub-national lockdowns in a bid to prevent importation and minimize local transmission. Given the weak health system in most African countries, mounting timely and robust responses to the COVID-19 pandemic will be a big challenge hence the need to focus on targeted and high impact prevention and control interventions that could break the chain of transmission quickly. This becomes more pertinent given the African context where inadequate access to water, sanitation and the extended family system renders the implementation of critical preventive measures such as hand washing and social distancing challenging. This is further compounded by the global shortage of required human and material resources, which is more glaring in Africa.

Due to the rapid spread and impact of the disease on human health, trade and travel, several research (mostly preliminary) have been conducted and published to characterize the virus and the dynamics of its transmission, prevention and control. While some of these publications have shown varying findings, conclusions and recommendations, many key and consistent evidences on the characteristics of the virus, its transmission, prevention and control are now emerging. This body of knowledge is critical to inform the development of timely, effective and context-specific prevention and control strategies in Africa. In this article, we review the relevant scientific literatures on the COVID-19 pandemic, and synthesize the relevant evidence that could potentially change the game in Africas fight against the disease; finally we propose strategic recommendations for prevention and control of COVID-19 transmission in the Africa continent specifically.

The initial characteristics of COVID-19 cases suggest that the disease is zoonotic [8]. However, recent scientific evidence demonstrates that the current transmission pattern globally is from human-to-human. The virus is similar to the severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS) viruses with susceptibility and severity associated with older age group [9, 10], male gender [11, 12] and underlying medical conditions such as poor immune functions, chronic diseases and surgery [13]. With a basic reproduction rate ranging from 2.6 to 4.71 [14, 15] and fatality rate from 2.3 to 11% [9, 16] it is more transmissible but less fatal compared to SARS and MERS [17, 18]. As is the case with most Influenza viruses, the transmission of SARS-CoV-2 significantly reduces with an increase in temperature and humidity [19, 20], however, this advantage may be offset by the high transmissibility of the virus.

Three main routes of transmission have been identified among humans namely ingestion or inhalation of contaminated droplets released into the air when a patient sneezes, coughs or talks, contact with surfaces which have been contaminated by infected persons and the inhalation of aerosols generated during some medical procedures [21, 22]. A few studies have also suggested faeco-oral transmission of the virus [23, 24]. A recent study concluded that the virus remains viable and infectious in aerosols for a few hours and up to a few days on surfaces, particularly on stainless steel and plastics [25]. While distinct signs and symptoms such as fever, dry cough, runny nose, difficulty in breathing, etc. have been associated with the disease, recent evidence suggests a high proportion of COVID-19 cases are infectious but undocumented either because they have mild or no symptoms but yet continue to transmit the disease [26]. This could contribute to the high transmissibility and rapid geographic spread of the virus.

Based on the lessons learnt from responding to the outbreak in China, prevention and control strategies have been proposed and are in use at various levels. In the absence of a vaccine, infection prevention and control measures that include measures to reduce or prevent exposure to the virus such as identification of suspected cases through syndromic screening at points of entry into countries, public places, health facilities, prevention of shedding of virus into the environment through respiratory hygiene have been recommended as prevention and control strategies in the general population [21]. Others include proper sanitation and waste management, social distancing to prevent contact with infected persons, avoidance of touching potentially contaminated surfaces, eyes, nose and mouth with contaminated hands and hand washing with soap and water or hand sanitizers which contain at least 60% alcohol [21]. Available evidence suggests that social distancing may have a dramatic effect on the transmission of SARS-CoV-2 and other respiratory infections, [27] but there may be renewed virus transmission following relaxation of such measures due to the large proportion of susceptible people that would still be in the population [28]. There is a convergent view on the important role of face masks in reducing the transmission of COVID-19 by protecting healthy persons who come into contact with an infected individual and by preventing infected persons from shedding the droplets into the environment [29, 30]. The use of face masks has also been associated with lower levels of anxiety and depression among the general population and health care workers which further supports its importance in prevention and control of the disease [31,32,33].

At the individual case level, timely diagnosis, isolation and supportive management of confirmed cases, identification and follow-up of their contacts, prevention of nosocomial transmission through strong infection prevention and control methods and use of personal protective equipment are recommended [34]. There is no known cure for the disease currently but several clinical trials involving various therapies are ongoing. WHO recommends that all laboratory confirmed cases should be isolated and managed in health facility settings but where this is not possible priority should be given to cases with the probability of poor outcomes such as those aged above 60years and with underlying medical conditions which put them at higher risk [35].

Putting the above scientific evidences on the characteristics and dynamics of COVID-19 transmission, prevention and control into perspective against the backdrop of the social, cultural and economic context in Africa, we deduce several lessons which could guide African countries to better prepare for and respond to the COVID-19 pandemic on the continent.

While the mostly hot and humid African weather and largely younger population may be deterrent factors for wide transmission of the disease, any advantage conferred by this is offset by the high transmissibility of the disease. This is more so given the high population density, larger families and large vulnerable populations such as refugees, Internally Displaced Persons (IDPs), people living with the human immunodeficiency virus (HIV), tuberculosis (TB) and malnutrition thus emphasis in African countries should be on prevention of the spread of infection, especially to these vulnerable groups. In this regard, African countries should invest in identifying, developing and implementing tailor-made prevention strategies to protect at risk populations from infection [36].

Given the high proportion of undocumented and asymptomatic cases of COVID-19, the use of syndromic surveillance for disease detection at points of entry may not be very effective [37]. While syndromic surveillance may offer some level of reassurance to governments and the general population, the cost in terms of the human and financial resources associated with conducting it may offset its benefits. African countries should rather invest in active search for cases and their contacts at the community and household levels particularly the asymptomatic contacts and transmitters through scaling up testing of all persons who may have been exposed to the virus but remain asymptomatic. To achieve this, COVID-19 testing strategies which prioritize massive testing of various categories of persons based on the transmission scenario should be developed. Additionally, efforts should be made to increase testing capacity and timeliness by decentralizing testing to the sub-national levels.

The evidence that the virus survives much longer on surfaces such as stainless steel and plastic as compared to respiratory droplets have far reaching implications for prevention and control of the virus at the population level. First, risk communication messages should emphasize the high risk constituted by surfaces such as doorknobs, stainless steel handrails, disposable plastics etc. and encourage people to refrain from unnecessary touching of such surfaces. Second, regular disinfection of such surfaces at the household and community level is advised and should be included in risk communication messages and during community engagement sessions [23]. Third, in the light of new findings on asymptomatic transmission of COVID-19 and recommendations on the usage of face masks by healthy individuals, African countries should define clear policies on the use of face masks. Such policies should ensure that face masks are available to those who need them particularly the frontline healthcare workers, caregivers and vulnerable groups, address the issue of shortage of masks and other supplies which is already a challenge in many African countries and importantly provide clear guidance to the general population on the pros and cons, safe use, donning and doffing of face masks. Furthermore, African scientists should pursue urgent researches into the use of locally available material for the production of face masks which are suitable to the African context [29, 30].

While available scientific evidence shows that the social distancing which is the ultimate aim of the current lockdowns and population movement restriction measures instituted by several African countries may reduce transmission of the virus in the short term, this strategy alone may not be enough to break the chain of transmission [28]. Since there is already widespread community transmission in many of these countries, population confinement may result in a change in the transmission pattern from the community to the household level [38]. Furthermore, African countries may not be able to sustain such lockdowns for a long time given their socioeconomic context thus they should focus on making the best use of the small window of opportunity that they offer. First, clear objectives should be set for lockdowns which should be to reduce transmission through the scale up of preparedness and response interventions and to control the outbreak in areas of transmission. These objectives should be communicated clearly to the general population to forestall community resistance to lockdowns which is being experienced in some of the African countries. Second, the definition of areas where to impose confinement should be guided by the epidemiology and pattern of transmission of the disease. Third, the lockdowns should be accompanied by intensive risk communication, active case search at the community and household levels, massive testing, contact tracing and isolation. Fourth, adequate preparation should be made to ensure that confined populations have access to basic services such as food, water, healthcare etc. during lockdowns in order to reduce community resistance andensure adherence. Fifth, appropriate strategies to prevent a second wave of the pandemic following the lifting of the lockdown measures should be developed and implemented [39].

Given the weak health systems in most of the infected African countries, institutional management of all laboratory confirmed cases may not be a feasible option. On the other hand, home management of such cases is constrained by several challenges due to the large household size, poor housing and high population density in many African countries. Countries should therefore develop context-specific case management strategies which should classify cases according to their risk and health needs, identify places such as health facilities and non-health facilities such as repurposed hostels, schools, hotels or stadia where the various categories of cases will be isolated, define and identify the minimum package of resources such as health workers, medicines, medical equipment and other logistics which are needed to effectively manage the anticipated caseloads. Such strategies should be based on the prevailing transmission scenario in the country.

The COVID-19 pandemic has overwhelmed even strong health systems in Europe and America. A review and analysis of the impact of the 20142015 Ebola outbreaks in West Africa on health systems revealed that there was a significant reduction in access to routine health services and this led to substantially increased mortality from preventable diseases such as malaria, measles, HIV, AIDS and TB. African countries should learn from this experience and implement available guidance from WHO to ensure that essential health services are maintained during the COVID-19 pandemic particularly during lockdowns to reduce excess mortality from other preventable diseases [40,41,42]. Key to maintenance of essential services during the COVID-19 pandemic is the protection of health care workers from acquiring COVID-19 infection; this can be achieved by providing African health workers with the necessary equipment, information and training on how to protect themselves [43].

Management of COVID-19 outbreaks in the situation of population displacement such as refugee and IDPs camps and in prisons and urban slums which are common in Africa is a major challenge. Other high-risk situations include in large-scale industries which employ a large number of semi-skilled workers [44]. The high transmissibility of the virus, overcrowding and inadequate access to social services such as water and sanitation will rapidly facilitate transmission of the virus and constrain implementation of preventive measures such as social distancing in such situations. African countries should, therefore, invest in the development of special public health strategies for prevention and control of outbreaks in such settings [36]. Establishment of COVID-19 information and testing centres near such areas is recommended to improve rapid access of the high-risk populations to COVID-19 prevention and control services [44].

Importantly, the lessons from the rapid spread of the virus in China, Italy, Iran, Republic of Korea and America should be a wake-up call for African countries to rapidly scale up risk communication, community engagement, and participation. The scientific evidence described above and outcomes of anthropological studies on COVID-19 should be used as the basis for development of evidence-based and context specific risk communication messages. Such risk communication messages should be focused on achieving behavioural change and tailor-made to address the several socio-cultural myths, stigma, misconceptions and rumours associated with the virus, its transmission, prevention and control.

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Moving from rhetoric to action: how Africa can use scientific evidence to halt the COVID-19 pandemic - Infectious Diseases of Poverty - BioMed Central

Pneuma Introduces the First Anti-Aging Serum that Corrects Wrinkles at the Source of Aging – N1o1 – BioSpace

AUSTIN, Texas, Oct. 23, 2020 /PRNewswire/ -- World renowned Biochemist, Dr. Nathan S. Bryan introduces N1o1, the first anti-aging skincare that uses a Nobel Prize winning discovery to defy aging skin by correcting the cause of wrinkled and damaged skin plus age spots and blemish prone skin. N1o1 http://www.n1o1.com, restores theage-related loss of a molecule called "Nitric Oxide" to improve the appearance of your skin, increase the youthful flow of oxygen and nutrients to your skin cells. Scientists call Nitric Oxide the Anti-aging Molecule.

https://pubmed.ncbi.nlm.nih.gov/21957583/

N1o1 features an innovative dual chamber bottle that helps activate your body's anti-aging molecules. Additionally, N1o1 delivers Vitamin C, a potent antioxidant, that prevents free radical damage. Four published studies show daily use of N1o1 vastly improves the appearance of wrinkles, discoloration, and the tone, quality, and texture of the skin. Continued use improves your results.

N1o1 is hypo-allergenic, safe and effective for all skin types. A temporary pinkness upon application indicates the immediate benefits of nitric oxide; optimized absorption and increased nutrient delivery to the skin cells. It can be used as a stand-alone skin treatment or to enhance your existing skincare products. For the ultimate age defying daily skincare routine, Pneuma will launch several companion products to create the most powerful anti-aging system with targeted results by the end of 2020.

Science has proven that the loss of nitric oxide accelerates the aging process. Our body's nitric oxide production diminishes with age, as much as 50% by age 40, and continues to steadily decline. Nitric oxide is a signaling molecule responsible for the delivery of oxygen and nutrients to every cell in the body. Without nitric oxide, cells become dysfunctional, the skin loses hydration and collagen plus, fine lines and wrinkles appear.

Backed by 20 years of science, N1o1 has four peer reviewed published clinical trials on its nitric oxide activating serum. In these studies, N1o1 was proven to dramatically improve the appearance of aging skin with an incredible 100% results satisfaction rating.

4 of the Clinical Studies:Clinical Aging Skin Study- Annals of Plastic and Reconstructive SurgeryClinical Active Acne Study- International Journal of Pharmaceutica Analytica ActaClinical Wound Healing Study- Surgical Case ReportsClinical Aesthetic Medicine Study- Journal of Surgery

For additional information, visit http://www.n1o1.com

Media ContactJanice McCafferty773-736-9034257438@email4pr.com

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The Benefits Of Synastol TC Explained – HAPPI – happi.com

The European Journal of Dermatology (Eur J Dermatol, doi 10.168/ejd.2020.3882) published Sytheon's detailed mechanistic study on Synastol TC,a standardizedTerminalia chebulafruit extract said to alter the expression of genes associated with skin architecture and barrier formation. Terminalia chebulafruit extract is a well-known herb in Ayruveda and iswell explored for its benefits. In Tibetans, TC is highly revered for its purifying attributes; in fact, its fruit is depicted in the hands of the medicine Budha, according to Sytheon.

Synastol TC is a standardized hydrolyzable tannin-enrichedTerminalia chebulafruit extract. The water-soluble extract contains >60% hydrolyzable tannins including chebulinic and chebulagic acids. Both components provide long-lasting antioxidant properties and work through biological mechanisms that provide preventative and restorative anti-aging and skin-toning benefits.

The abstract notes that genome-wide expression responses to a standardized tannin-enriched extract, called Synastol TC, were investigated in three-dimensional reconstituted human skin tissues through microarray studies. TC responses were the opposite to those observed in cells exposed to oxidative stress, solar-simulated UV radiation and wounding, with increased expression of genes associated with water homeostasis, skin barrier establishment, blood vessel development and circadian rhythms when compared to tissues treated with water.Also, the key keratinocyte (KC) differentiation makersFLG & LORand hydration marker AQP9 were further confirmed atmRNA and protein levels.

Consistent with these results, TC increased the expression of transcription factors regulating KC differentiation (FOS,GHRL3,PPARG) as well as key genes involved in skin architecture, such as collagens (COL1A1, COL1A2, COL5A1, COL6A6, COL6A3, COL6A1), proteoglycans (PRELP, OGN) and other matrisomes.

Sytheon noted that recent studies showed that Collagen type VI plays a dual role in ECM functions and also has innate immune functions with activity againstS. aureus, S.pneumonia, E. coli and P. aeruginosa. In separate assays, TC also inhibited MMP enzymes (MMP-1, MMP-2, MMP-3, MMP-9, MMP-12).

Overall, the results from these studiesvalidate that Synastol TC stimulates positive modifications within skin that are not merely superficial but deep and multi-targeted, according to Sytheon.The combined targeting of several endpoints provides better chances of delivering true benefits in skin, in sharp contrast to the old one-product-one-target dogma (mostly from undefined extracts) that currently permeates the cosmetic industry.

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The Benefits Of Synastol TC Explained - HAPPI - happi.com

Global Medical Aesthetics Market 2020 Indepth Study Including COVID 19 Update with of Top Key Players Profile of industry – re:Jerusalem

Global Medical Aesthetics Market research report makes use of SWOT analysis and Porters Five Forces analysis to disclose the strengths, weaknesses, opportunities, and threats in the industry. Analysis and discussion of important industry trends, market size, market share estimates are also covered in this persuasive market report. The report gives out the CAGR value fluctuation during the forecast period of 2020-2027 for the market. The Global Medical Aesthetics Market report studies various inhibitors as well as motivators of the market in both quantitative and qualitative manner so that users can have perfect information.

An international Global Medical Aesthetics Market report takes into account key market dynamics including the current market scenario and future prospects of the sector. It also gives the company profile, product specifications, production value, contact information of manufacturer and market shares for company. The statistics are signified in graphical and tabular format for a clear understanding on facts and figures. All the numerical data included in the report is backed up by excellent tools such as SWOT analysis, Porters Five Forces Analysis and others. The report also analyses the emerging trends along with major drivers, challenges and opportunities in the Global Medical Aesthetics Market.

Global medical aesthetics marketis projected to register a healthy CAGR of 12.1% in the forecast period of 2019 to 2026.

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Competitive Analysis: Global Medical Aesthetics Market

Some of the major players operating in the global medical aesthetics market are Allergan, Bausch Health Companies Inc., Lumenis, Shanghai Fosun Pharmaceutical Group Co. Ltd., Cynosure, Syneron Medical Ltd, Aerolase Corp., A.R.C. Laser Gmbh, Asclepion Laser Technologies Gmbh, Btl, Cutera, Eclipse, Lutronic, Mentor Worldwide Llc, Merz Pharma, Quanta System, Sciton Inc., Sharplight Technologies Inc, Syneron Medical Ltd., Venus Concept.

Aesthetics devices are an innovative advancement, providing a solution to patients which deal with the ingenuity of creating beauty. The medical aesthetics devices is a growing market owing to its benefits such as maintaining the youthful appearance, pain free and non-invasive beauty treatments, maintenance free skin that remains smooth and hairless without the need for shaving, waxing or unpleasant hair treatments, improving the cosmetic appearance, and technological advancement in medical aesthetics devices.

The market is showing a substantial growth in the emerging countries as these countries are adapting to the trends of urbanization. Brazil, South Africa, Thailand and many others have improved in the past one decade. People are opting different aesthetics surgeries to maintain themselves, which give them better results without any stressful physical efforts. Medical Aesthetics is one of the most trending concepts of the 21stCentury which will show a substantial increase in the future as there is a great technological advancement and innovation in the field by the companies dealing with these devices making them safer and even less invasive leading to more population opting for these procedures.

Segmentation: Global Medical Aesthetics Market

Global medical aesthetics market is segmented into 4 notable segments such as product type, type of care, accessories and end user

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Insights of the market

This report will enable both of the sides in market be an established firm or a relative new entrant. It helps the established firms to know about the moves which are being performed by their competitors and also helps the new entrants by educating them about the market situations and the industry trends. The report helps to strategically profile key players and comprehensively analyze their market position in terms of ranking and core competencies, and detail the competitive landscape for market leaders while also describing and forecast the market, in terms of value, for various segments, by region North America, Europe, Asia Pacific (APAC), and Rest of the World (RoW).

Analysis based on

Product Launch:

Allergan

The company was founded in 2013 and headquartered at Dublin, Ireland. The company is focused on developing, manufacturing and commercializing branded device, biologic, pharmaceutical, surgical and regenerative medicine products for patients throughout the world. The main business segments are US Specialized Therapeutics, US General Medicine, International. The revenue of the company in healthcare sector 2018 was USD 16,550.8 Million. The company has global presence in North America, Asia Pacific, South America, Europe and Middle East & Africa.

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Bausch Health Companies Inc.

The company was founded in 1959 and headquartered at Quebec, Canada. The company is engaged in manufacturing and marketing a broad range of branded and generic pharmaceuticals, over-the-counter (OTC) products and medical devices. The main business segments are Bausch + Lomb/International, Branded Rx, U.S. Diversified Products. The revenue of the company in healthcare sector 2018 was USD 8,174.8 Million. The company has global presence in North America, Europe, the Middle East, Africa, Asia Pacific and Latin America.

Luimenis

The company was founded in 1991; headquarter in Yokeneam, Israel. The company is engaged in the field of minimally-invasive clinical solutions for the Surgical, Ophthalmology and Aesthetic markets, and expert in developing and commercializing innovative energy-based technologies, including Laser, Intense Pulsed Light (IPL) and Radio-Frequency (RF). The company has global presence in North America, South America, Europe, Asia, Africa and Australia.

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Global Medical Aesthetics Market 2020 Indepth Study Including COVID 19 Update with of Top Key Players Profile of industry - re:Jerusalem

Semi Automatic Biochemistry Analyzer Market Analysis and Global Outlook During 2020 to 2026 – The Think Curiouser

The global report of Semi Automatic Biochemistry Analyzer Industry explores the company profiles, product applications, types and segments, capacity, production value, and market shares for each and every company. The Report Monitors 2020 to 2026 Market Development Trends Of All Semi Automatic Biochemistry Analyzer Market Report And Analysis Of Demand, Consumption-Production And Market Trends.

Click Here to Get Latest Sample PDF Copy of updated research 2020 for Free https://www.marketinsightsreports.com/reports/10212372721/global-semi-automatic-biochemistry-analyzer-market-research-report-2020/inquiry?Source=TC&Mode=72

Top Companies in the Global Semi Automatic Biochemistry Analyzer Market areErba Group(ERBA Diagnostics Mannheim), EKF Diagnostics, Balio Diagnostics, Randox, Agappe Diagnostics Switzerland GmbH, Genrui Biotech Inc., Alphatec Scientific, Seleo, Meril Life Sciences, SFRI, BioSystems, Biosys, Paramedical, Diagnovision, CONTEC, Rayto Life and Analytical Sciences and Others.

This report segments the market on the basis ofTypesare

Medical

Veterinary

On The basis Of Applications, the market is segmented into are

Hospitals

Clinics

Veterinary Hospitals

Veterinary Clinics

Laboratory

Others

(Exclusive Offer: Upto 40% Discount on this report)The browse Full report description and TOChttps://www.marketinsightsreports.com/reports/10212372721/global-semi-automatic-biochemistry-analyzer-market-research-report-2020?Source=TC&Mode=72

Regions covered By Semi Automatic Biochemistry Analyzer Market Report 2020 To 2026 areNorth America (The United States, Canada, and Mexico), Asia-Pacific (China, India, Japan, South Korea, Australia, Indonesia, Malaysia, and Others), Europe (Germany, France, UK, Italy, Russia, and Rest of Europe), Central & South America (Brazil, and Rest of South America), and Middle East & Africa (GCC Countries, Turkey, Egypt, South Africa, and Other).

Impact of the Semi Automatic Biochemistry Analyzer market report is

Comprehensive evaluation of all opportunities and risks in the market.

Semi Automatic Biochemistry Analyzer market ongoing developments and significant occasions.

Detailed study of business techniques for development of the market-driving players.

Conclusive study about the improvement plot of market for approaching years.

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Favorable impression inside imperative mechanical and publicize latest examples striking the market.

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Semi Automatic Biochemistry Analyzer Market Analysis and Global Outlook During 2020 to 2026 - The Think Curiouser

Vanderbilt biochemists reveal the cause of Charcot-Marie-Tooth diseasetoo much of a good thing – Vanderbilt University News

Vanderbilt researchersincludingCharles Sanders, associate dean for research and professor of biochemistry, and graduate studentJustin Marinkohave illuminated the cause of Charcot-Marie-Tooth disease, putting them on the road to developing therapeutic approaches for the disease that affects one in 2,500 people.

The discovery was published in the article Direct Relationship Between Increased Expression andMistraffickingof the Charcot-Marie-Tooth-Associated Protein PMP22 published in theJournal of Biological Chemistryon July 9. The significance and overall importance of the findings within the article earned it the rare distinction of Editors Pick.

Charcot-Marie-Tooth disease is known to cause the peripheral nerves to stop working, causing loss of dexterity and the sense of touch in the hands and feet. Over two decades, Sanders has been studying a targeted approach to treat Charcot-Marie-Tooth disease and other neuropathies by looking at rarely examined proteins.

The lab shutdown brought on by COVID-19 afforded Marinko time to more deeply analyze data previously collected in the lab. Marinkos work with this data showed that overproduction of the membrane protein PMP22 is too much of a good thing; it turns individual cells into traps.

During the safer-at-home period, we started to think about our large dataset and the layers within that data that could be analyzed in ways that we had not previously considered, said Marinko, who also is winner of theAnne Karpay Award. A very positive outcome came as a result of having some time to think about the data more thoroughly.

In healthy cells, there are two copies of the gene encoding PMP22, a protein that snakes through the lipid bilayer of the cell several times until it reaches the cell surface. Under disease conditions, a third copy adds more PMP22 to the cell in a way that overloads its pathway to the exterior of the cell, leading to most of the protein getting trapped within the cellwhere it becomes toxic and disease-causing. This research is the first experimental evidence that definitively points to this mechanism as the cause of the most common form of Charcot-Marie-Tooth disease. A similar phenomenon likely occurs for other proteins in other disorders involving unregulated cell behavior, including some forms of cancer.

The investigation is the outcome of a continuing collaboration between the Sanders Lab and that ofBruce Carter, professor of biochemistry and an associate director of theVanderbilt Brain Institute.

Discovering this relatively new phenomenon was an important step and a highlight for our lab, said Sanders, also the Aileen M. Lange & Annie Mary Lyle Chair in Cardiovascular Research.I am thrilledabout the future of this workwith our friends in the Carter Lab, translating our data and model cell line work to nervous system cells.

The work was supported by NIH grants R01 NS095989 and R01 NS107456, NIH fellowship F31 NS113494 and NIH training grant T32 NS00749.

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Vanderbilt biochemists reveal the cause of Charcot-Marie-Tooth diseasetoo much of a good thing - Vanderbilt University News

Synthesis, Characterization, and Toxicity Assessment of Pluronic F127- | IJN – Dove Medical Press

Suhaili Shamsi,1 Addison Alvin Alagan,1 Seri Narti Edayu Sarchio,2 Faizah Md Yasin3,4

1Laboratory of Animal Biochemistry and Biotechnology, Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia; 2Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia; 3Department of Chemical and Environmental Engineering, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia; 4Institute of Advanced Technology, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia

Correspondence: Suhaili ShamsiLaboratory of Animal Biochemistry and Biotechnology, Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, MalaysiaTel +603-9769 7964Fax +603-9769 7590Email sh_suhaili@upm.edu.my

Background: In the current literature, there are ongoing debates on the toxicity of graphene oxide (GO) that demonstrate contradictory findings regarding its toxicity profile. As a potential drug carrier, these findings are very concerning due to the safety concerns in humans, as well as the dramatic rise of GO being excreted into the environment. Therefore, there is an imperative need to mitigate the potential toxicity of GO to allow for a safer application in the future.Purpose: The present study aims to address this issue by functionalizing GO with Pluronic F127 (PF) as a means to mitigate toxicity and resolve the biocompatibility of GO. Although results from previous studies generally indicated that Pluronic functionalized GO exhibits relatively low toxicity to living organisms, reports that emphasize on its toxicity, particularly during embryonic developmental stage, are still scarce.Methods: In the present study, two different sizes of native GO samples, GO and NanoGO, as well as PF-functionalized GO, GO-PF and NanoGO-PF, were prepared and characterized using DLS, UV-Vis, Raman spectroscopy, FTIR, and FESEM analyses. Toxicological assessment of all GO samples (0 100 g/mL) on zebrafish embryonic developmental stages (survival, hatching and heart rates, and morphological changes) was recorded daily for up to 96 hours post-fertilization (hpf).Results: The toxicity effects of each GO sample were observed to be higher at increasing concentrations and upon prolonged exposure. NanoGO demonstrated lower toxicity effects compared to GO. GO-PF and NanoGO-PF were also found to have lower toxicity effects compared to native GO samples. GO-PF showed the lowest toxicity response on zebrafish embryo.Conclusion: These findings highlight that toxicity is dependent on the concentration, size, and exposure period of GO. Functionalization of GO with PF through surface coating could potentially mitigate the toxicity effects of GO in embryonic developmental stages, but further investigation is warranted for broader future applications.

Keywords: graphene oxide, pluronic, nanomaterial, toxicity, embryogenesis

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Scientists discover new organic compounds that could have helped form the first cells – Newswise

Newswise Chemists studying how life started often focus on how modern biopolymers like peptides and nucleic acids contributed, but modern biopolymers don't form easily without help from living organisms. A possible solution to this paradox is that life started using different components, and many non-biological chemicals were likely abundant in the environment. A new survey conducted by an international team of chemists from the Earth-Life Science Institute (ELSI) at Tokyo Institute of Technology and other institutes from Malaysia, the Czech Republic, the US and India, has found that a diverse set of such compounds easily form polymers under primitive environmental conditions, and some even spontaneously form cell-like structures.

Understanding how life started on Earth is one of the most challenging questions modern science attempts to explain. Scientists presently study modern organisms and try to see what aspects of their biochemistry are universal, and thus were probably present in the organisms from which they descended. The best guess is that life has thrived on Earth for at least 3.5 billion of Earth's 4.5 billion year history since the planet formed, and most scientists would say life likely began before there is good evidence for its existence. Problematically, since Earth's surface is dynamic, the earliest traces of life on Earth have not been preserved in the geological record. However, the earliest evidence for life on Earth tells us little about what the earliest organisms were made of, or what was going on inside their cells. "There is clearly a lot left to learn from prebiotic chemistry about how life may have arisen," says the study's co-author Jim Cleaves.

A hallmark of life is evolution, and the mechanisms of evolution suggest that common traits can suddenly be displaced by rare and novel mutations which allow mutant organisms to survive better and proliferate, often replacing previously common organisms very rapidly. Paleontological, ecological and laboratory evidence suggests this occurs commonly and quickly. One example is an invasive organism like the dandelion, which was introduced to the Americas from Europe and is now a common weed causing lawn-concerned homeowners to spend countless hours of effort and dollars to eradicate. Another less whimsical example is COVID-19, a virus (technically not living, but technically an organism) which was probably confined to a small population of bats for years, but suddenly spread among humans around the world. Organisms which reproduce faster than their competitors, even only slightly faster, quickly send their competitors to what Leon Trotsky termed the "ash heap of history." As most organisms which have ever existed are extinct, co-author Tony Z. Jia suggests that "to understand how modern biology emerged, it is important to study plausible non-biological chemistries or structures not currently present in modern biology which potentially went extinct as life complexified."

This idea of evolutionary replacement is pushed to an extreme when scientists try to understand the origins of life. All modern organisms have a few core commonalities: all life is cellular, life uses DNA as an information storage molecule, and uses DNA to make ribonucleic RNA as an intermediary way to make proteins. Proteins perform most of the catalysis in modern biochemistry, and they are created using a very nearly universal "code" to make them from RNA. How this code came to be is in itself enigmatic, but these deep questions point to their possibly having been a very murky period in early biological evolution ~ 4 billion years ago during which almost none of the molecular features observed in modern biochemistry were present, and few if any of the ones that were present have been carried forward.

Proteins are linear polymers of amino acids. These floppy strings of polymerised amino acids fold into unique three-dimensional shapes, forming extremely efficient catalysts which foster precise chemical reactions. In principle, many types of polymerised molecules could form similar strings and fold to form similar catalytic shapes, and synthetic chemists have already discovered many examples. "The point of this kind of study is finding functional polymers in plausibly prebiotic systems without the assistance of biology, including grad students," says co-author Irena Mamajanov.

Scientists have found many ways to make biological organic compounds without the intervention of biology, and these mechanisms help explain these compounds' presence in samples like carbonaceous meteorites, which are relics of the early solar system, and which scientists don't think ever hosted life. These primordial meteorite samples also contain many other types of molecules which could have formed complex folded polymers like proteins, which could have helped steer primitive chemistry. Proteins, by virtue of their folding and catalysis mediate much of the complex biochemical evolution observed in living systems. The ELSI team reasoned that alternative polymers could have helped this occur before the coding between DNA and protein evolved. "Perhaps we cannot reverse-engineer the origin of life; it may be more productive to try and build it from scratch, and not necessarily using modern biomolecules. There were large reservoirs of non-biological chemicals that existed on the primeval Earth. How they helped in the formation of life-as-we-know-it is what we are interested in," says co-author Kuhan Chandru.

The ELSI team did something simple yet profound: they took a large set of structurally diverse small organic molecules which could plausibly be made by prebiotic processes and tried to see if they could form polymers when evaporated from dilute solution. To their surprise, they found many of the primitive compounds could, though they also found some of them decomposed rapidly. This simple criterion, whether a compound is able to be dried without decomposing, may have been one of the earliest evolutionary selection pressures for primordial molecules.

The team conducted one further simple test. They took these dried reactions, added water and looked at them under a microscope. To their surprise, some of the products of these reaction formed cell-sized compartments. That simple starting materials containing 10 to 20 atoms can be converted to self-organised cell-like aggregates containing millions of atoms provides startling insight into how simple chemistry may have led to complex chemistry bordering on the kind of complexity associated with living systems, while not using modern biochemicals.

"We didn't test every possible compound, but we tested a lot of possible compounds. The diversity of chemical behaviors we found was surprising, and suggests this kind of small-molecule to functional-aggregate behavior is a common feature of organic chemistry, which may make the origin of life a more common phenomenon than previously thought," concludes co-author Niraja Bapat.

###

Tokyo Institute of Technology (Tokyo Tech)stands at the forefront of research and higher education as the leading university for science and technology in Japan. Tokyo Tech researchers excel in fields ranging from materials science to biology, computer science, and physics. Founded in 1881, Tokyo Tech hosts over 10,000 undergraduate and graduate students per year, who develop into scientific leaders and some of the most sought-after engineers in industry. Embodying the Japanese philosophy of "monotsukuri," meaning "technical ingenuity and innovation," the Tokyo Tech community strives to contribute to society through high-impact research.

The Earth-Life Science Institute (ELSI)is one of Japan's ambitious World Premiere International research centers, whose aim is to achieve progress in broadly inter-disciplinary scientific areas by inspiring the world's greatest minds to come to Japan and collaborate on the most challenging scientific problems. ELSI's primary aim is to address the origin and co-evolution of the Earth and life.

The World Premier International Research Center Initiative (WPI)was launched in 2007 by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) to help build globally visible research centers in Japan. These institutes promote high research standards and outstanding research environments that attract frontline researchers from around the world. These centers are highly autonomous, allowing them to revolutionise conventional modes of research operation and administration in Japan.

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Scientists discover new organic compounds that could have helped form the first cells - Newswise

Electrolyte and Biochemistry Analyzers Market: Study Navigating the Future Growth Outlook : Abbott, Hitachi, Horiba Medical – Stock Market Vista

Latest Study on Industrial Growth ofGlobal Electrolyte and Biochemistry Analyzers Market2019-2025. A detailed study accumulated to offerLatest insights about acute features of the Electrolyte and Biochemistry Analyzers market. The report contains different market predictions related to market size, revenue, production, CAGR, Consumption, gross margin, price, and other substantial factors. While emphasizing the key driving and restraining forces for this market, the report also offers a complete study of the future trends and developments of the market. It also examines the role of the leading market players involved in the industry including their corporate overview, financial summary and SWOT analysis.

The Major Players Covered in this Report: Roche, Danaher, Siemens, Abbott, Hitachi, Horiba Medical, Mindray, ThermoFisher, Shanghai Kehua Bio-Engineering Co., Ltd, Senlo, Sunostik, ELITec Group, Sysmex, Jiangxi TECom, URIT Medical Electronic, Randox Laboratories, Dirui, Shenzhen Rayto, Convergent Technologies, Meizhou Cornley, Diestro, Caretium, Erba Mannheim, Hycel Medical, Idexx Laboratories, Nova Biomedical, SFRI, Medica, Shenzhen Genius Biotech Inc & Sensa Core

Electrolyte and Biochemistry Analyzers Market Study guarantees you to remain / stay advised higher than your competition. With Structured tables and figures examining the Electrolyte and Biochemistry Analyzers, the research document provides you a leading product, submarkets, revenue size and forecast to 2025. Comparatively is also classifies emerging as well as leaders in the industry.Click To get SAMPLE PDF (Including Full TOC, Table & Figures)

This study also covers company profiling, specifications and product picture, sales, market share and contact information of various regional, international and local vendors of Global Electrolyte and Biochemistry Analyzers Market. The market opposition is frequently developing greater with the rise in scientific innovation and M&A activities in the industry. Additionally, many local and regional vendors are offering specific application products for varied end-users. The new merchant applicants in the market are finding it hard to compete with the international vendors based on reliability, quality and modernism in technology.

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The titled segments and sub-section of the market are illuminated below:

In-depth analysis of Global Electrolyte and Biochemistry Analyzers market segments by Types: , Product Type Segmentation, Electrolyte Analyzers & Biochemistry Analyzers

Major Key Players of the Market: Roche, Danaher, Siemens, Abbott, Hitachi, Horiba Medical, Mindray, ThermoFisher, Shanghai Kehua Bio-Engineering Co., Ltd, Senlo, Sunostik, ELITec Group, Sysmex, Jiangxi TECom, URIT Medical Electronic, Randox Laboratories, Dirui, Shenzhen Rayto, Convergent Technologies, Meizhou Cornley, Diestro, Caretium, Erba Mannheim, Hycel Medical, Idexx Laboratories, Nova Biomedical, SFRI, Medica, Shenzhen Genius Biotech Inc & Sensa Core

Regional Analysis for Global Electrolyte and Biochemistry Analyzers Market: APAC (Japan, China, South Korea, Australia, India, and Rest of APAC; Rest of APAC is further segmented into Malaysia, Singapore, Indonesia, Thailand, New Zealand, Vietnam, and Sri Lanka) Europe (Germany, UK, France, Spain, Italy, Russia, Rest of Europe; Rest of Europe is further segmented into Belgium, Denmark, Austria, Norway, Sweden, The Netherlands, Poland, Czech Republic, Slovakia, Hungary, and Romania) North America (U.S., Canada, and Mexico) South America (Brazil, Chile, Argentina, Rest of South America) MEA (Saudi Arabia, UAE, South Africa)

Furthermore, the years considered for the study are as follows:Historical year 2014-2019Base year 2019Forecast period** 2020 to 2025 [** unless otherwise stated]

**Moreover, it will also include the opportunities available in micro markets for stakeholders to invest, detailed analysis of competitive landscape and product services of key players.

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Guidance of the Global Electrolyte and Biochemistry Analyzers market report:

Detailed considerate of Electrolyte and Biochemistry Analyzers market-particular drivers, Trends, constraints, Restraints, Opportunities and major micro markets. Comprehensive valuation of all prospects and threat in the Global Electrolyte and Biochemistry Analyzers market. In depth study of industry strategies for growth of the Electrolyte and Biochemistry Analyzers market-leading players. Electrolyte and Biochemistry Analyzers market latest innovations and major procedures. Favorable dip inside Vigorous high-tech and market latest trends remarkable the Market. Conclusive study about the growth conspiracy of Electrolyte and Biochemistry Analyzers market for forthcoming years.

What to Expect from this Report On Electrolyte and Biochemistry Analyzers Market:

1. A comprehensive summary of several area distributions and the summary types of popular products in the Electrolyte and Biochemistry Analyzers Market.2. You can fix up the growing databases for your industry when you have info on the cost of the production, cost of the products, and cost of the production for the next future years.3. Thorough Evaluation the break-in for new companies who want to enter the Electrolyte and Biochemistry Analyzers Market.4. Exactly how do the most important companies and mid-level companies make income within the Market?5. Complete research on the overall development within the Electrolyte and Biochemistry Analyzers Market that helps you elect the product launch and overhaul growths.

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Detailed TOC of Electrolyte and Biochemistry Analyzers Market Research Report-

Electrolyte and Biochemistry Analyzers Introduction and Market Overview Electrolyte and Biochemistry Analyzers Market, by Application [????????????]

Electrolyte and Biochemistry Analyzers Industry Chain Analysis Electrolyte and Biochemistry Analyzers Market, by Type [, Product Type Segmentation, Electrolyte Analyzers & Biochemistry Analyzers]

Industry Manufacture, Consumption, Export, Import by Regions (2014-2019) Industry Value ($) by Region (2014-2019)

Electrolyte and Biochemistry Analyzers Market Status and SWOT Analysis by Regions

Major Region of Electrolyte and Biochemistry Analyzers Marketi) Global Electrolyte and Biochemistry Analyzers Salesii) Global Electrolyte and Biochemistry Analyzers Revenue & market share Major Companies List Conclusion

Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Asia.

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Electrolyte and Biochemistry Analyzers Market: Study Navigating the Future Growth Outlook : Abbott, Hitachi, Horiba Medical - Stock Market Vista