OmniTier Streamlines Personalized Medicine Workflows with CompStor Insight for Next-Generation Sequencing Tertiary Analysis – BioSpace

Oct. 27, 2020 12:00 UTC

The only tertiary analysis appliance on the market, CompStor Insight delivers 7x faster annotation in an easy to use solution with integrated workflows, multi-user support, needing no special IT skills

MILPITAS, Calif.--(BUSINESS WIRE)-- OmniTier Inc., an AI and multiomics application company whose bioinformatics solutions help deliver the promise of personalized medicine, debuted the CompStor Insight appliance for tertiary analysis in next-generation sequencing (NGS) applications. In benchmark results, CompStor Insight enables a 7x improvement in gene annotation performance allowing researchers to spend more time developing treatment innovations, and less time on data processing.

OmniTier made the announcement coincident with the ASHG 2020 virtual meeting, where it will showcase CompStor Insight and other members of the CompStor genomics analysis product family.

Our researchers are very busy because we need to analyze and interpret complex variants of many patients, said Kazuhiro Nitta, lecturer at Juntendo Universitys Graduate School of Medicine in Tokyo, and part of the Intractable Disease Research Center. He collaborated with OmniTier on CompStor Insight product development. It was an enjoyable experience to work with the innovative team at OmniTier. With the level of automation and sophisticated filtering that is supported by CompStor Insight, we estimate we could reduce the amount of time for downstream analysis of multi-genomic data sets dramatically.

Personalized medicine initiatives have put the spotlight on tertiary analysis as the most complex step in NGS, where scientists seeking better treatments for cancer or rare diseases investigate variants identified during secondary analysis. Competing open source solutions and internally developed applications in use today for tertiary analysis often exhibit low level of functional automation and require long data ingress-compute-egress cycles delay time to actionable data that does not scale with more server nodes.

CompStor Insight is the first tertiary analysis appliance on the market and enables faster time to results, and low per-subject cost. With an easy set up and straightforward Web browser interface, it provides push-button workflows for annotation, filtering, visualization and querying variant data. Utilizing OmniTiers proprietary MemStac tiered memory technology, CompStor Insight can process up to several thousand genome datasets at speed, enabling faster and more accurate interpretation of data in genome-wide-association studies (GWAS) and rare disease analysis. Because CompStor Insight is designed to interface to a wide range of standard and custom knowledge databases including ClinVar and gnomAD, teams have access to a wide set of reference data at their fingertips. Being a stand-alone appliance, CompStor Insight can store subject data locally in on-premise storage, or leverage cloud storage options.

In testing, CompStor Insight delivered a 7x reduction in run time to annotate typical WGS data, compared to Ensembl VEP. For NGS service businesses, where time is money, CompStor accelerates the annotation and filtering functions dramatically, providing an opportunity to grow their revenue and profit easily.

When used with OmniTiers secondary analysis appliance, CompStor Novos, organizations benefit from an end-to-end analytics solution, from sequencer output, advanced variant calling, and fast annotation, to state-of-the-art multisubject tertiary analysis. Pharmaceutical and biotech companies can take advantage of CompStor Insights intuitive GWAS workflows to identify biomarkers for drug development and develop subject selection strategies.

As the cost of gene sequencing decreases, many organizations are looking for faster, easier ways to learn from each patients data, and convert data to knowledge, said Christi Bird, principal consultant and fellow in Frost & Sullivan's Transformational Health Growth consulting team. OmniTier is addressing a key growth market as the bioinformatics industry works to enable the mass adoption of genomic medicine.

Researchers are straining to meet the explosive demand for personalized medicine with analytics that burden them with complexity and delays that impede the ability to turn data into knowledge and then treatments, said Hemant Thapar, CEO and founder of OmniTier. CompStor Insight is enabling the low per subject cost and faster turnaround time to actionable data that is critical to delivering better treatments for hundreds of diseases and genetic conditions.

CompStor Insight appliances will start shipping to pharmaceutical and research organizations in December 2020. For more information or to request pricing please visit http://www.omnitier.com.

About OmniTier Inc.

OmniTier develops AI and multiomics appliances and software for bioinformatics, scientific computing, and web services applications that deliver affordable real-time solutions to enrich everyday living. Its integrated appliance solutions accelerate data-intensive infrastructure applications, including genomic workflows and scientific analysis for machine learning and AI. Founded in February 2015, the company has R&D operations in Milpitas, CA and Rochester, MN.

CompStor Insight is for research purposes only. CompStor, CompStor Insight and MemStac are trademarks of OmniTier, Inc. CompStor Novos is a registered trademark of OmniTier, Inc.

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OmniTier Streamlines Personalized Medicine Workflows with CompStor Insight for Next-Generation Sequencing Tertiary Analysis - BioSpace

Saphetor Partners with Roche Turkey to Advance New Treatments for SMA – Business Wire

LAUSANNE, Switzerland--(BUSINESS WIRE)--Saphetor, a global precision medicine company and the creator of VarSome, the emerging global standard platform for human genome data, announced today a partnership with Roche Turkey. The collaboration will be centered around supporting Roches drug discovery initiatives into Spinal Muscular Atrophy (SMA).

The open genomics community VarSome.com brings together a vast global network of clinical and research genetic laboratories. Saphetor will facilitate connecting labs who wish to partner with Roche on SMA research. The goal will be to create and foster relationships as well as to accelerate scientific collaboration with SMA community.

Exploring new and more efficient way for scientific collaboration has long been an obstacle in the pharmaceutical industry. Saphetor is helping to avoid the loss of critical time through identifying the most relevant patients and facilitating the communication between involved parties such as labs, pharma and patients.

Anne Nijs, Transformation Leader, Rare Conditions for Pharma International at Roche said: We look forward to leveraging Saphetors innovative approach to bring together the global genomics community in order to connect with the right participants in the healthcare ecosystem of rare disorders.

Dr. Turgut Gkalp, SMA Rare Conditions Partner for Turkey, Azerbaijan and Georgia added: We are always looking for new ways to identify new stakeholders and therefore new collaboration opportunities. I believe our partnership with Saphetor will give us a better understanding of SMA testing landscape in Turkey.

Andreas Massouras, CEO of Saphetor commented: We are very excited to partner with Roche and contribute to their important effort in developing treatments for this debilitating and often lethal disease. VarSome.com is proving an extremely valuable resource for willing clinical and research labs as well as pharmaceutical companies to collaborate on a worldwide level.

About SMA

Spinal muscular atrophy (SMA) is a severe, inherited, progressive neuromuscular disease that causes devastating muscle atrophy and disease-related complications. It is the most common genetic cause of infant mortality and one of the most common rare diseases, affecting approximately one in 11,000 babies. SMA leads to the progressive loss of nerve cells in the spinal cord that control muscle movement. Depending on the type of SMA, an individuals physical strength and their ability to walk, eat or breathe can be significantly diminished or lost.

SMA is caused by a mutation in the survival motor neuron 1 (SMN1) gene that results in a deficiency of SMN protein. SMN protein is found throughout the body and increasing evidence suggests SMA is a multi-system disorder and the loss of SMN protein may affect many tissues and cells, which can stop the body from functioning.

About Roche

Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve peoples lives. The combined strengths of pharmaceuticals and diagnostics under one roof have made Roche the leader in personalised healthcare a strategy that aims to fit the right treatment to each patient in the best way possible.

Roche is the worlds largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and diseases of the central nervous system. Roche is also the world leader in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management.

Neuroscience is a major focus of research and development at Roche. The companys goal is to develop treatment options based on the biology of the nervous system to help improve the lives of people with chronic and potentially devastating diseases.

Roche has more than a dozen investigational medicines in clinical development for diseases that include multiple sclerosis, spinal muscular atrophy, neuromyelitis optica spectrum disorder, Alzheimers disease, Huntingtons disease, Parkinsons disease, Duchenne muscular dystrophy and autism.

About VarSome and Saphetor SA

VarSome is the emerging global standard platform for human genome data. With more than 300,000 professional users and 80+ standardized and continuously updated major datasets freely searchable online, varsome.com is the world's largest community and knowledge base for human genome variant data. VarSome's premium, clinical and API tools further enable anyone and any organization, from individual healthcare professionals to hospitals and pharmaceutical companies, to harness and apply the power of this community and data to improve health and lives worldwide. VarSome is created by Saphetor, a Switzerland-based precision medicine company using bioinformatics to apply human genome data to benefit people.

VarSome Clinical is CE-IVD-certified and HIPAA-compliant, allowing fast and accurate variant discovery, annotation, and interpretation of NGS data for whole genomes, exomes, and gene panels, which helps clinicians reach faster and more accurate diagnoses and treatment decisions for genetic conditions.

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Saphetor Partners with Roche Turkey to Advance New Treatments for SMA - Business Wire

The Anatomy Of An Election Disinformation Campaign – WBUR

The anatomy of a disinformation campaign. How does a bad faith post get mistaken for the truth? We talk about how the tentacles of disinformation reach into millions of homes.

Nina Jankowicz, disinformation fellow at the Wilson Center, a nonpartisan think tank. Author of "How To Lose the Information War." (@wiczipedia)

Secretary Frank LaRose, Ohio Secretary of State. Republican. (@FrankLaRose)

New York Times: "Facing a Deluge of Misinformation, Colorado Takes the Offensive Against It" "Like so many modern election sagas, it started with a tweet. In 2019, Jena Griswold, the newly installed secretary of state in Colorado, saw a tweet falsely claiming that her states election system had been hacked, using a picture of voting equipment as evidence."

NPR: "Robocalls, Rumors And Emails: Last-Minute Election Disinformation Floods Voters" "Dirty tricks and disinformation have been used to intimidate and mislead voters for as long as there have been elections. But they have been especially pervasive this year as millions of Americans cast ballots in a chaotic and contentious election."

The Columbus Dispatch: "Secretary of state: Hacking, voter intimidation by Russia and Iran haven't affected Ohio" "Ohio Secretary of State Frank LaRose said the best way voters can respond to Iran and Russia meddling in U.S. elections is to cast a ballot."

New York Times: "Russia Poses Greater Election Threat Than Iran, Many U.S. Officials Say" "While senior Trump administration officials said this week that Iran has been actively interfering in the presidential election, many intelligence officials said they remained far more concerned about Russia, which in recent days has hacked into state and local computer networks in breaches that could allow Moscow broader access to American voting infrastructure."

ABC News: "Russia, Iran have obtained voter data in election interference campaign: DNI" "Senior national security officials alerted the American public Wednesday that Iran and Russia have both obtained voter data in their efforts to interfere in the 2020 U.S. election."

New York Times: "Twitter Will Turn Off Some Features to Fight Election Misinformation" "Twitter took steps on Friday to slow the way information flows on its network, even changing some of its most basic features, as alarm grows that lies and calls for violence will sweep through social media in the weeks surrounding the presidential election."

Washington Post: "FBI says it has nothing to add to Ratcliffes remarks about Hunter Biden, Russian disinformation" "The FBI notified Congress late Tuesday that it has nothing to add at this time to a statement made by President Trumps director of national intelligence disputing the idea that Russia orchestrated the discovery of a computer that may have belonged to Joe Bidens son."

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The Anatomy Of An Election Disinformation Campaign - WBUR

How Greys Anatomy Revolutionized Pop Culture and Why Its Not Done Yet – Variety

She might change her mind; she certainly has before. But midway through an interview, Ellen Pompeo casually drops the bomb that after more than 360 episodes, the upcoming 17th season of Greys Anatomy may be its last.

We dont know when the show is really ending yet, Pompeo says, answering a question that was not at all about when the show might end. But the truth is, this year could be it.

Pompeo has played Meredith Grey the superstar surgeon around whom Greys Anatomy revolves since its start. The show, created by Shonda Rhimes, premiered on ABC on March 27, 2005, and became an immediate, noisy hit. Since then, for a remarkably long time in Hollywood years, the drama has been among the most popular series on TV, even as the landscape of television has changed seismically. At its Season 2 ratings height, the program drew an average audience of 20 million viewers. And all these years later in a TV universe now divided by more than 500 scripted shows Greys ranks as the No. 1 drama among 18- to 34- year-olds and No. 2 among adults 18 to 49. In delayed, multiplatform viewing, Season 16 averaged 15 million viewers.

Strikingly, technology is such that teenagers who were born when the show premiered, and later binged Greys on Netflix, watch new episodes live with their parents. The series has spawned two successful spinoffs for ABC, Private Practice (which ran from 2007 to 2013) and Station 19 (which enters its fourth season this fall). Greys Anatomy has been licensed in more than 200 territories across the world, translated into more than 60 languages, and catapulted the careers of music artists from Ingrid Michaelson and Snow Patrol to Tegan and Sara and the Fray whose songs have played during key emotional sequences.

In its explosive initial success, Greys Anatomy was an insurgent force in popular culture. The Season 1 cast featured three Black actors Chandra Wilson, James Pickens Jr. and Isaiah Washington as doctors in positions of power at the Seattle hospital where the show is set, and Sandra Oh played the ambitious intern Cristina Yang, who would become Merediths best friend. For the women characters, the Greys approach to sex was defiant and joyful, starting in the pilot with Merediths one-night stand with Derek (Patrick Dempsey), who turned out to be one of her bosses at the hospital.

Rhimes presented these images to the world like they were no big deal, when in fact, nothing like Greys had ever been seen on network television. Krista Vernoff has been the Greys Anatomy showrunner since Season 14, as anointed by Rhimes, and was the head writer for the first seven seasons. She remembers the moment she realized how radical Greys was a medical show driven entirely by its characters instead of their surgeries as she watched an episode early in Season 1. My whole body was covered in chills, Vernoff recalls. I was like, Oh, we thought we were making a sweet little medical show and were making a revolution.

Gizelle Hernandez for Variety

Still, no one expected Greys Anatomy to become the longest-running primetime medical drama in TV history, outlasting MASH and ER, the previous record-holder. Since 2005, Greys has inspired countless women to become doctors, and along the way, its depiction of illness has even saved a few lives. The show has remained popular through three presidential administrations, the Great Recession, tectonic shifts in how people watch TV and two cultural reckonings one feminist, one anti-racist that demonstrate how ahead of its time Greys Anatomy has always been.

And theyre not done yet. When Season 17 premieres on Nov. 12, Greys Anatomy will tackle the subject of the coronavirus as experienced by the doctors at Grey Sloan Memorial, all while filming under strict COVID-19 protocols. The season is dedicated to frontline workers. And Pompeo, a producer on Greys whose Meredith has removed a live bomb from a patients body, was in a plane crash, was widowed after Derek died in a car accident, was beaten nearly to death by a patient and, in a separate incident, actually did die briefly after a ferry accident is intent on making the show top itself once again.

Im constantly fighting for the show as a whole to be as good as it can be. As a producer, I feel like I have permission to be able to do that, Pompeo says. I mean, this is the last year of my contract right now. I dont know that this is the last year? But it could very well could be.

Pompeo has been refreshingly transparent about her fight to become the highest-paid female actor on television, having detailed a few years ago how she negotiated a paycheck for more than $20 million a year. She clearly knows what shes doing with these frank pronouncements as well.

As Pompeo laughs over the phone from her car, she says in a near shout: Theres your sound bite! Theres your clickbait! ABCs on the phone!

The Greys Anatomy team led by Rhimes and executive producer Betsy Beers created the first season in a vacuum, because the show did not have an airdate. The 2004-05 season was a comeback year for ABC because Desperate Housewives and Lost, both of which debuted that fall, became phenomena not only ratings successes but also watercooler events.

But at Greys, Rhimes was getting noted to death by network president Steve McPherson. According to Vernoff, McPherson who resigned in 2010 under a cloud of sexual harassment allegations stonewalled with pushback every step of the way, as ABCs then- head of drama, Suzanne Patmore Gibbs, fought for the show. Vernoff was close with Patmore Gibbs, who died in 2018, and recalls her talking about her clashes with McPherson.

He just didnt get it; he didnt like it, Vernoff continues. Honestly, Im going to say, I dont think he liked the ambitious women having sex unapologetically.

Wilson, when she was cast as Miranda Bailey on Greys, was a New York theater actor (Caroline, or Change) relatively new to series television. But she was well aware of the networks issues. We took a creative break around the Christmas holiday, which to me meant Oh, were out of a job.

Gizelle Hernandez for Variety

Pompeo was frustrated: Once we finally got an airdate, two weeks before that airdate they wanted to change the title of the show to Complications.

In an email to Variety, McPherson disputed these assertions, saying, I made the original deal with Shonda. I developed Greys Anatomy at the studio. I picked it up at ABC. He praised Patmore Gibbs, and added, As for defaming me again and again, I dont know what to say other than its sad that anyone feels the need to spread lies about me.

Yet there was so little faith in the show that the writers were asked to clear out their offices when they finished the season. But to Vernoff, who had clicked right away with Rhimes, the early episodes had felt like a labor of love.

And it was worth the battle. We fought for the right for Meredith and Bailey to be whole human beings, with whole sex lives, and not a network TV idea of likable, Vernoff says. You might not have been likable, but now youre iconic.

As far as the medicine went, the cases were often ostentatious. Every kind of crazy accident that had ever caused terrible harm to any human ever, that was our homework at night, Vernoff says. It was up to Zoanne Clack, an emergency room doctor-turned-writer, to be a sounding board in the writers room. She began as the only doctor on staff during the first season, and is now an executive producer. What was interesting was that the writers dont have those boundaries because they dont know the rules, so they would come up with all of these scenarios, and my immediate thought was like, No way! Clack says. Then Id have to think about it and go, But could it?

When the program finally premiered on a Sunday night after Desperate Housewives to massive ratings, it was a shock to the cast and crew, given that they had shot the first season under a cloud, Pompeo says, adding, So the fact that the numbers were that huge the first time we aired was a big fk-you to
McPherson!

With Season 2 now a given, everything changed, Vernoff says: It was like a hurricane-force gale, and everyone was just trying to hold on. They had made 13 episodes for Season 1, airing nine of them and holding the final four for Season 2 Meredith finding out that Derek was actually married (to Addison, played by Kate Walsh) had felt like the perfect finale. But upon the writers return, Vernoff says, the feeling was Holy s. We have to make 22.

The entire cast mostly unknown actors like Katherine Heigl as the sunny Izzie Stevens, T.R. Knight as the chummy neurotic George OMalley, and Justin Chambers as the troubled, secretly vulnerable Alex Karev had become famous overnight. For Wilson, whose Bailey was the stern teacher the interns called the Nazi, it was a new experience. Folks were scared to talk to me, like in the store or in the Target people would just kind of leave me alone, she says. It was like, Whats going on?

According to Vernoff, Paparazzi were following the cast to work it was wild.

Gizelle Hernandez for Variety

The mid- to late-2000s were the height of glossy gossip magazines such as Us Weekly (and its copycats), as well as the inception of TMZ and Perez Hilton as celebrity-hounding, news-breaking forces that fueled (and soiled) the fame-industrial complex. The cast of Greys Anatomy was firmly in the sights of these new, often toxic forces in media.

Pompeo says the cast was so talented that it was all worth it but yes, the transition to stardom was hard for the group: At the time, it was just a real combination of exhaustion and stress and drama. Actors competing with each other and envious.

Heigl, Knight and Isaiah Washington all went through press cycles that made the show seem scandal-prone. To rehash it all now seems pointless; you can look it up. Washington was fired in June 2007. Knight and Heigl asked to be written out of the show preemptively, in Seasons 5 and 6, respectively.

Vernoff and the other writers were watching the internal messes unfold. They had to deal with how the fallout affected the shows plot, as when Washington was fired just as Burke, his character, was about to marry Cristina. When word comes down that an actor is leaving the show, and what youve got scripted is a wedding Vernoff trails off, laughing.

There was a lot of drama on-screen and drama off-screen, and young people navigating intense stardom for the first time in their lives, she continues. I think that a lot of those actors, if they could go back in time and talk to their younger selves, it would be a different thing. Everybodys grown and changed and evolved but it was an intense time.

Pompeo doesnt want to talk about what happened with individual actors from the show, because when she has in the past, it doesnt get received in the way in which I intend it to be. But she does make a point about the way television is produced. Nobody should be working 16 hours a day, 10 months a year nobody, she says. And its just causing people to be exhausted, pissed, sad, depressed. Its a really, really unhealthy model. And I hope post-COVID nobody ever goes back to 24 or 22 episodes a season.

Its why people get sick. Its why people have breakdowns. Its why actors fight! You want to get rid of a lot of bad behavior? Let people go home and sleep.

Debbie Allen would eventually be Pompeos savior in that regard, but that was years away. Allen an actor and a dancer began her directing career when she was on the 1980s TV series Fame as a natural progression because, she says, I was in charge of the musical numbers, and so many directors didnt really know how to shoot them. She went on to be a prolific director and producer, most notably overhauling NBCs A Different World after a tumultuous first season. As a fan of Greys Anatomy, Allen wanted to work on the show, and in Season 6, she was hired to direct. To prepare for it, Allen shadowed Wilson, who had been tapped to direct by executive producer-director Rob Corn. (He came to me and said, You should direct, says Wilson, who has now helmed 21 episodes. And I said, OK. Because I didnt know what else to say.)

Gizelle Hernandez for Variety

Directing that sixth-season episode led to Allens fruitful relationship with Greys. In Season 8, Rhimes wrote Allen into the show to play Catherine, a star surgeon, a love interest for Richard Webber (Pickens) and the mother of Jackson Avery (Jesse Williams). Ahead of Season 12 in 2015, Allen became the shows EP/director. Her duties included hiring all of the directors, weighing in on scripts and casting, and, as Allen puts it, minding that people feel good about themselves. Several years before the revived #MeToo movement would lead to calls for systemic changes behind the camera in Hollywood, Allen set a goal of hiring 50% women directors. She also increased the number of Black men who directed Greys during her first season as executive producer, among them Denzel Washington. (When she sold him on it, she recounts, he said to her, Im going to say yes, Debbie Allen.)

Pompeo and Allen are close. Allen began her new role the year after Dempsey left, at a time when we were really broken, Pompeo says. And so much of our problems were perpetuated by bad male management. Debbie came in at a time when we really, really needed a breath of fresh air, and some new positive energy.

Pompeo continues with a laugh: Debbie really brought in a spirit to the show that we had never seen we had never seen optimism! We had never seen celebration. We had never seen joy!

According to Pompeo, Allen began advocating for her to have more humane hours Fridays off (Pompeo: And I was like, What? What? Fridays off?) and for the show to shoot 12-hour days maximum, and ideally no more than 10 hours (Pompeo: And I was like, I love this woman.).

Allen speaks affectionately about her bond with Pompeo. Coming out of Boston, shes so earthy and real in a way that you might not know, Allen says. Theres a sisterhood between us I guess you would say its almost a Blackness that exists between us. And shes part of our tribe.

Allen has been a key member of the Greys Anatomy brain trust since Season 12, and two seasons later, Vernoff returned to run the show. Shed left at the end of Season 7, consulted on Private Practice for a few years, and then went to Showtimes Shameless for five seasons. As her contract was set to expire, Rhimes asked Vernoff to lunch, and told her she wanted her to take over. It felt like she was saying, Hey, our kid needs you, Vernoff says.

Before accepting the offer, Vernoff had to catch up on the show. She had always written Greys as a romantic comedy, and what she saw on-screen during her binge was dark as hell especially after Dereks death. If this show that you are currently making is the show that you want Greys Anatomy to be, she recalls telling Rhimes, I am, in fact, not the right writer for it. But Rhimes was insistent, saying it was time for a change after the mourning period for Derek.

Vanessa Delgado, who started as a production intern during the seventh season and has worked her way up to being lead editor and co-producer, says the shows trajectory shifted when Vernoff came back it was a return to the original, saucier tone of Greys. We changed the music completely, Delgado says. The dialogue felt lighter and more fun, and we were having fun again.

Gizelle Hernandez for Variety

That lightness will be difficult to maintain this year, of course, when, as Allen puts it, COVID is No. 1 on the call sheet right now.

Vernoff at first wondered whether Greys should ignore the coronavirus, thinking the audience comes to the show for relief. But the doctors in the writers room convinced her this wasnt the time for escapism, saying to her, This is the biggest medical story of our lifetime, and it is changing medicine permanently.

When theyve had doctors and nurses come speak with them this season, Vernoff says, they were different human beings than the people weve been talking to every year. And I want to honor that,
tonally. I just want to inspire people to take care of each other.

Pompeo, who is not shy about offering criticism, sounds positively enthusiastic: Ill say the pilot episode to this season girl, hold on.

What nobody thinks we can continue to do, we have done. Hold on. Thats all were going to say about that!

Pompeo has a few more months before she decides whether she wants to continue and as Rhimes and ABC have made clear in recent years, the show will likely end when she leaves. I dont take the decision lightly, Pompeo says. We employ a lot of people, and we have a huge platform. And Im very grateful for it.

You know, Im just weighing out creatively what can we do, she says. Im really, really, really excited about this season. Its probably going to be one of our best seasons ever. And I know that sounds nuts to say, but its really true.

Vernoff doesnt worry about the creative well drying up. Weve blown past so many potential endings to Greys Anatomy that I always assume it can go on forever, she says.

And Wilson knows how important Greys is to its audience, in that the characters have essentially become people who live in their house. As one of only three actors whove been on Greys since the beginning the other is James Pickens Jr. Wilson is in it until the end: In my mind, Bailey is there until the doors close, until the hospital burns down, until the last thing happens on Greys Anatomy. That is her entire arc.

Whenever the show does conclude, part of its legacy will be about the talent it launched into the world, beginning with Rhimes, who will soon release her first shows for Netflix, after her company, Shondaland, made a lucrative deal with the streamer in 2017.

But it will also be about the characters of Greys Anatomy mostly women and people of color who are trying to make the world a better place as they find friendship, love and community.

The show, at its core, brings people together, Pompeo says. And the fact that people can come together and watch the show, and think about things they may not have ordinarily thought about, or see things normalized and humanized in a way that a lot of people really need to see it helps you become a better human being. If this show has helped anybody become a better human being, then thats the legacy Id love to sit with.

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How Greys Anatomy Revolutionized Pop Culture and Why Its Not Done Yet - Variety

Anatomy of a Goal: Dynamo own goal gifts the Crew a draw – Massive Report

Welcome back to the Anatomy of a Goal, where each week we dissect one goal (or near goal) from Columbus Crew SCs previous match.

For match 19 of the 2020 MLS Season, we take a look at Victor Cabreras 67th minute own goal that gave the Crew a goal and led to a draw in Saturdays match against Houston Dynamo.

Here is a look at the own goal by the Dynamo defender.

Columbus took the field in Houston with Darlington Nagbe in the lineup for the first time since early September. While Nagbe completed nearly all of his passes, the Black & Gold showed the same road match rust that we have come to expect this season. A Memo Rodriguez goal in the first half gave the Dynamo a lead that carried until the 67th minute.

The game-tying goal begins with a Pedro Santos interception. Santos picks off the ball and sends a pass back toward Milton Valenzuela.

Valenzuela picks up Santos interception and slides the ball over to Artur to set up the offense.

Artur spies Harrison Afful, hidden underneath the on-screen advertisement, and hits a field-switching pass to the right back.

Afful takes a few touches toward the sideline and pays a pass forward to Luis Diaz.

Diaz crosses midfield and finds himself with four options. He can play a pass forward to Lucas Zelarayan, carry the ball toward the middle of the field, play a long diagonal back to Artur or drop a pass to Aidan Morris.

Diaz plays a safe pass back to Morris.

Morris carries forward and looks to make a pass back forward to Diaz, but has to get the ball around Darwin Ceren.

Ceren sticks a foot out and is able to get in the way of Morris pass to Diaz.

Luckily, Cerens interception deflects right to Harrison Afful.

Afful immediately hits a pass right to Morris.

Morris carries the ball forward and resets back to Artur.

Artur moves the ball forward and finds himself with three options. He can either play a pass forward to Zelarayan, hit a long diagonal to Santos or play a pass up to Valenzuela.

Artur makes the safe pass over to Valenzuela.

And Valenzuela makes a safe pass right back to Artur.

Artur picks up Valenzuelas pass and sends a long ball over to Jonathan Mensah who is open in the middle of the field.

Mensah finds Aidan Moors a dozen yards ahead of him.

Morris lets the ball roll ahead of him and hits a very good first touch pass forward to Afful.

Afful corrals Morris pass and carries it a few yards forward, where he hits a pass into the path of Diaz.

Diaz turns toward the goal and hits a low cross into the penalty box toward Krisztian Nemeth.

Maynor Figureoa is the first obstacle between Diazs cross and Nemeth.

The ball just edges past Figueroa as Cabrera gets between Nemeth and the ball.

Cabrera slides toward the ball in an attempt to clear it out of bounds. The Dynamo center back gets a touch on the ball, preventing Nemeth from getting on the end of the cross.

Fortunately for Columbus, Cabreras attempted clearance rockets toward the Houston goal.

Marko Maric gets his hand up but isnt able to react quickly enough as the ball soars past him . . .

. . . into the back of the net!

Findings:

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Anatomy of a Goal: Dynamo own goal gifts the Crew a draw - Massive Report

Anatomy of a Killing by Ian Cobain review a death that casts new light on the Troubles – The Guardian

In certain parts of Northern Ireland in the late 1970s, a stranger arriving at the door could provoke panic, even terror. The town of Lisburn, near Belfast, was not such a place. Predominantly Protestant and home to many members of the Royal Ulster Constabulary (RUC), it had for the most part escaped the violence that had ravaged other parts of the province. Up until 1977, as Ian Cobain puts it, not a single member of the security forces had lost their life in Lisburn.

All that would change on the morning of Saturday, 22 April 1978, when Millar McAllister, a police photographer, opened the back door of his home in Woodland Park, having glimpsed a figure moving in his back garden. He was shot three times at close range, twice in the chest and the third time, as he was lying on the ground, in the head. In the silence that followed, the killer noticed McAllisters seven-year-old son, Alan, standing just inside the kitchen door, frozen to the spot. They stared at each other for a long moment until the boy started screaming. The stranger ran to a waiting car, the boys cries echoing in his head,

In Lost Lives, the vast book of historical record that chronologically documents every death in the Troubles, Millar McAllister is listed as victim number 2,017. The bare facts of his life are outlined thus: RUC, Protestant, 36, married, two children. In Anatomy of a Killing, Ian Cobain rescues him from the abyss of history, tracing the arc of his short life and contrasting it with the still ongoing, altogether more tangled, life of Harry Murray, his killer.

By reconstructing a single murder its planning, its ruthless execution and its protracted aftermath through in-depth interviews and the careful sifting of not always reliable evidence from official records, Cobain also casts new light on the culture of terrorist violence and state repression that defined Northern Ireland during 30 years of conflict.

Cobain is a seasoned, award-winning investigative journalist (most recently for the Guardian), who also sketches the social and historical context that spawned the Troubles. Throughout, his style is brisk and his tone level-headed, the violence he chronicles often evoked through spartan, but chillingly descriptive, detail. Of the aftermath of the IRA bombing of the La Mon hotel restaurant, which happened on 17 February 1978, just a few months before the murder of Millar McAllister, he writes: Twelve people, including three married couples, died in the blast. All were Protestant. The dead were so badly burned and shrivelled by the flames that firemen thought initially that some of them were children. Hell is in the details.

Amid such carnage, the death of an individual could pass all too swiftly into the anonymous realm of statistics, forgotten by all but family members and loved ones. Cobains book is, among other things, an act of reclamation. It is also, in its skilful telling, a tale of two ordinary lives converging with the inexorability of a Greek tragedy.

Millar McAllister joined the RUC in 1961, when the Troubles, as Cobain puts it, were barely visible on the horizon. He had two hobbies: photography and racing pigeons. The former provided him with a well-paid job; the second unwittingly led to his death. McAllister wrote a monthly column for Pigeon Racing News and Gazette under the byline The Copper, which was accompanied by his photograph. When an IRA suspect, who was being held at the Castlereagh interrogation centre in east Belfast, recognised McAllister from the photo, the word went out to find him. Soon afterwards, Harry Murray was dispatched with another young volunteer to carry out his execution.

In almost every way, Murray comes across as the polar opposite of the level-headed McAllister: impetuous, impressionable and instinctively rebellious. What they had in common is that they were both Protestants, Murray being one of the very few from his community to join the IRA. A few years before, he had been driven out of his home in loyalist Tigers Bay in Belfast by local paramilitaries. His transgression was to marry a Catholic. Having been resettled where his wife grew up in nationalist north Belfast, he grew increasingly sympathetic to the republican cause. Murray seems to have drifted into the ranks of the Provisionals much like, years before, he had enlisted on impulse with the Royal Air Force and served overseas. His military career ended abruptly after one too many breaches of discipline. I just couldnt take orders, he tells Cobain without irony.

What lingers longest is the awful mundanity of the events leading up to and after the killing

Murrays renegade life was not without principle, however. During his induction into the IRA, he claims to have told his recruiters there were two things he would not do: kneecappings and shooting Protestants just because they were Protestant. Like all IRA combatants, though, he regarded the RUC as the enemy in a just war, and, as Cobain discovers, remains remarkably free of remorse for the brutal taking of Millar McAllisters life. In 1983, while serving time for the killing, Murray would take part in an audacious IRA jailbreak from Long Kesh prison, shooting a prison officer in the leg before being wounded himself. On his recapture, he was set upon by prison officers who berated him as a turncoat bastard.

As with Patrick Radden Keefes recent book, Say Nothing, which uses the IRAs disappearance of Jean McConville in 1972 as the starting point for an illuminating exploration of the conflict, Anatomy of a Killing deftly merges history, social context and anecdotal testimony. Cobain explores the psychology of political violence, citing a study from 1978 which found that, rather than being the psychopaths of tabloid headlines, the IRAs political killers tended to be normal in intelligence and mental stability. He also suggests that vengeance may have been a crucial motivating factor for young men joining the Provisionals and, in Murrays case, it is clear that he has never forgiven his own community for the humiliation of his expulsion.

The immediate aftermath of the killing also makes for deeply unsettling reading. On information obtained from an IRA informer, Murray and his accomplices were arrested and taken to Castlereagh, where they were beaten and interrogated relentlessly by Special Branch men working in shifts. Anne, an IRA courier, confesses to her role and, Cobain writes, appears to have suffered a fairly complete physical and psychological breakdown.

The man she gave the gun to after the killing, Brian Maguire, whom Cobain describes as highly strung, was not an IRA member. He was interrogated non-stop for 12 hours and, the next morning, was found hanged in his cell. His death remains disputed. Among the revelations in Cobains book is testimony given at the time by another suspect called Phelim, which provides what Cobain calls an accurate description of the torture technique that became known as waterboarding when used by the CIA in the years after 9/11.

If there is much that is compelling in Anatomy of a Killing, what lingers longest is the awful mundanity of the events leading up to and after the killing. Cobain describes how, on that fateful morning, Anne calmly carried the gun from Belfast to Lisburn on a bus, and, having arrived early, went shopping for a birthday present for her brother. Just a few hours after he killed McAllister, Murray returned to Lisburn to play football on a pitch close to his victims home.

As the Troubles begin to fade into history and forgetting, it is in these incidental actions that the deep moral fracture caused by the conflict comes sharply and chillingly into focus. We would do well to remember how quickly violence can become almost normalised in a culture riven by intractable differences of identity and belonging.

Anatomy of a Killing: Life and Death on a Divided Island by Ian Cobain is published by Granta (18.99). To order a copy go to guardianbookshop.com. Delivery charges may apply

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Anatomy of a Killing by Ian Cobain review a death that casts new light on the Troubles - The Guardian

The Anatomy of a California Legislative Resolution – California Globe

In the California Legislature, Members of the Assembly and Senate can introduce three types of resolutions. What are the component parts of a resolution? In terms of its anatomy, a resolution contains the following provisions:

Legislative Session. At the top of each bill, the following language appears: California Legislature 2019-2020 Regular Session. The only two items that change would be the 2-year Legislative Session, and if there is an Extraordinary Session (also called a special session), rather than a Regular Session.

Resolution Number, which follows the words House Resolution, Senate Resolution, Assembly Concurrent Resolution, Senate Concurrent Resolution, Assembly Joint Resolution, and Senate Joint Resolution. The Assembly Chief Clerk or the Secretary of the Senate assigns the resolutions their numbers for each resolution introduced in its respective house of origin, usually in the order in which it was received at the Assembly or Senate Desk. This number remains the same throughout the legislative process, even when the measure is considered in the second house.

Author(s), as well as principal coauthors and coauthors. In the U.S. Congress and many state legislatures, the author of the bill is known and referred to as the sponsor. In the California Legislature, the author is the legislator who authors the resolution. The first line always lists the main author(s) who introduced the resolution. Below the first line lists any principal coauthor and the next line lists any coauthor. One list is used for the house of origin coauthors and another line below that is used for coauthors from the other house.

Date Introduced, as well as Date Amended, with the house making the amendment listed (i.e., the Senate or Assembly).

Resolution Title, which is a short phrase, also called the Relating clause because it begins with the phrase: Relative to . The title must encompass the subject matter contained in the resolution.

Legislative Counsels Digest, merely states what the resolution would do.

Digest Key, which contains only the fiscal committee key.

Resolution Text, which is the actual language of the resolution, containing Whereas and Resolved clauses. These are the provisions that make up the anatomy of a bill in the California Legislature.

Chris Micheli is a lobbyist with Aprea & Micheli, as well as an Adjunct Professor of Law at the University of the Pacific McGeorge School of Law.

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The Anatomy of a California Legislative Resolution - California Globe

Monkey Dust and the Anatomy of a Tabloid Drug Scare Story – VICE UK

Screengrabs via North Wales Live, Stoke-on-TrentLive, Sky News, MailOnline and The Sun. Background: Pixabay

Newspapers distort the truth and dehumanise societys most vulnerable people when they report on drug scares, a new scientific study has found.

Public health experts at Liverpool John Moores University used the Monkey Dust epidemic in England during the summer of 2018 to pick apart how the media invokes the marmalade dropper drug scare story one that shocks Middle Englands newspaper readers into dropping their marmalade at breakfast in order to sell papers.

The study analysed 368 newspaper articles about the terrifying new drug in reality not one substance but a variety of potent, addictive synthetic cathinone stimulants such as MDPV and MDPHP that have been around for a while.

Researchers found that the media frenzy around Monkey Dust had all the inaccurate, hyped-up ingredients of a classic drug scare story: a brand new drug, more potent than any other, spreading to a town near you and with the power to transform people into violent sub-humans. It found that this kind of reporting not only exploited the poorest and sickest people in society for shock factor, but also made it harder for them to get help and put them in increased danger.

A swathe of 2018 newspaper reports, complete with lurid images, told readers that Monkey Dust was turning homeless people into zombie-like savages with superhuman powers. Vulnerable drug users were compared to the Incredible Hulk, while Stoke-on-Trent, the West Midlands city at the centre of the deluge of media reports, was like a scene from the Night of the Living Dead.

Monkey Dust originally the name of a satirical cartoon show in the early 2000s first appeared in a 2013 article in local Staffordshire newspaper The Sentinal about a murder case in which the perpetrator was alleged to be high on the drug known as monkey dust when he battered a man to death with a baseball bat. The drug was mentioned again in a couple of national papers in 2015, when a traveling salesman who chucked a cigarette through an elderly persons letter box and a robber dressed as Cruella de Vil were both said to be high on it.

But it was in the summer of 2018 that the Monkey Dust media feeding frenzy began. Sensationalist reports in the local and mainstream media including the BBC, Daily Mirror and The Telegraph began referring to the drug as evil, demon-like and abhorrent.

They were not sure what Monkey Dust actually was, but it was ten times stronger than coke, worse than heroin with cravings similar to meth. One local paper described it as the terrifying new street drug that turns users into zombies for just 2.

But drug users were not just zombies. According to many newspapers they were also cannibals. Alongside pictures of Hannibal Lecter, a series of articles suggested cannibalism was an effect of intoxication because it can make people who take it want to eat other peoples faces off.

Like escaped zoo animals, Monkey Dust users, newspapers said, were a highly unpredictable threat to the public who were unable to feel pain, deranged and could lash out at any time with unnatural strength. Sky News reported about a video showing one man, apparently high on the drug, leaping off the roof of a house onto a car, before getting straight up and attacking a police officer. They are just not of this world, said the Daily Mail.

Problem was, as VICE News reported at the time, and the study confirmed, the Great British Monkey Dust Panic while creating widespread clickbait alarm was not quite what it seemed.

The study found the media exaggerated the levels of use of the drug, its effects and the geographical extent of its use. Stories said people committed acts while high on Monkey Dust with little evidence they had taken it. The viral video of the man high on Monkey Dust jumping off a roof turned out to be from 2014, with no proof of what hed taken, while the line about the drug causing users to eat people had been cut and pasted from another, long ago debunked scare story from America.

Like most drug scare stories, from PCP and crystal meth to mephedrone and hippy crack, the study said local and national newspapers fed off each other. Once a false piece of information, or an outrageous quote was published, it spread across the media unchecked.

The media erroneously turned what was in reality a very localised story and a small group of disadvantaged people into a national threat. Far from plaguing the streets of the UK, Monkey Dust was largely confined to the Stoke area. Nevertheless the Daily Mail reported that all too many grim pockets of Britain were being transformed into the Incredible Hulk.

What most concerned the studys authors however was that drug scare stories such as the one about Monkey Dust have a direct, negative impact on societys most socially excluded people. Newspapers used anonymised photographs of homeless people and images of monsters to make drug users look a threat, instead of people struggling with serious problems.

Vulnerable groups were presented as the other and a group that should be excluded from city centre locations, said the study. People who use drugs were positioned as a drain on resources, through the pressures placed on public services, their perceived lack of economic contribution to society, and the negative effects of their physical presence in town centres as damaging to local economies.

Very few articles gave any explanation as to why people in Stoke-on-Trent might be getting high on drugs such as Monkey Dust, the study said. There was little mention of the austerity-fuelled social conditions, such as rising poverty and cuts to local services, that may have led to people becoming homeless and addicted to Monkey Dust in the first place, observed the study.

It might seem like harmless tabloid fun painting societys most socially excluded people as not of this world, but the study authors said these dehumanising stories have grave consequences. The study said that stigmatising drug users makes them less likely to seek help and means the authorities are less likely to give them it. Worse, it can put them in increased danger from members of the public and the police. In America, media myths about the power of drugs to make people superhuman have had a huge impact such as the killing by police of George Floyd in Minneapolis on the over-violent, and sometimes deadly, policing of drugs there.

The development of the meth zombie image in America, popularised by the use of dehumanising Faces of Meth mugshots, has been used to sew panic and injustice in communities, stigmatise the poor and hand down thousands of overly harsh sentences. The same can be said for crack in the US and for heroin in the UK. In Britain, the portrayal in the media of Spice users as inhuman zombies has made it easier for the public, police and the authorities to ignore why these people are taking drugs in such harmful way and for some to see them purely as objects of derision and disgust.

Media reporting has real life impact in that it can lead to increased police action, and in turn the further criminalisation of people who use drugs. It can have real life impact on the lived experiences of drug users by influencing public perceptions and attitudes, concluded the report.

It is important to change these narratives to prevent the negative effects of media reporting, and the need to ensure journalists report drug issues in ways that are better informed to prevent further harm to people who use drugs, and for policy makers to reconsider reactions to news media reporting that reproduce ineffective policy responses.

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Monkey Dust and the Anatomy of a Tabloid Drug Scare Story - VICE UK

Anatomy Opens the Creaking Door to Haunted House Tales – WIRED

Haunted house stories are having a moment. It might be quarantine. Or it could be Netflix's faultits release of The Haunting of Bly Manor has reinvigorated the discourse about what makes a good haunted house story and whether or not Mike Flanagan, the horror director who, between Bly Manor and Hill House and Doctor Sleep seems to be veritably obsessed with them, really has what it takes to make one that feels both scary and fascinating.

Haunted houses are special because houses are special. They keep us safeuntil they don'tand are both entirely familiar to us and entirely unfamiliar, as anyone who's had to deal with serious home repairs could tell you. People have intimate relationships with the places where they live. And that's a powerful entry path for horror. Or, as the opening line of Kitty Horrorshow's 2016 video game Anatomy puts it, "In the psychology of the modern civilized human being, it is difficult to overstate the significance of the house."

Horrorshow's game starts with a tape player in an empty kitchen and a single cassette. When you put it in, the narration begins, a faux-academic exploration of what houses mean, why they're special, and, most important, how people might think of them anatomically. Is a kitchen a stomach? Is a living room a heart? In what ways are houses like us?

All of this occurs, by the way, in an empty, modern suburban home. Two bathrooms, two bedrooms, a little narrow set of stairs. One peculiarity of haunted house stories is that they're often period pieces. It's the distance, I think: Old ornate Victorian-style homes are familiar without being too familiar. We want to think about how scary houses can be without actually letting that horror fully inside. Anatomy, a small game released on itch.io for PC, refuses that distance. This could be the house you grew up in. Or one you rented, for a while, in college, a lonely, dull little home at the end of a lonely, dull little cul-de-sac. It might be a lot like the one you live in right now.

The voice in the tape continues: "But of all the structures mankind has invented for itself, there is little doubt that the house is that which it relies upon most completely for its continued survival."

Anatomy understands the haunted house story. It understands why houses are scary and fascinating, and why artists from Henry James to Shirley Jackson to Mike Flanagan have been so obsessed with them. And alongside scaring you, Anatomy also wants to teach you. It is, in some sense, an exercise in explaining the jokeits narration delves into what is so frightening about a haunted house. But it's an exercise that's so effective and so deeply dialed in to the core of human fears that even when you understand it, you're still unnerved.

Here's how it's played: You find that first tape, in the kitchen of an empty, dark house. Then a message onscreen tells you to find another tape, in another room. In this way you explore the house, gathering tapes, listening to this voice contrasted with the uneasy, shadowy presence of the house. A presence that grows, as the house becomes more and more alien, as it begins to feel like something is there. Or maybe it's just the house itself, broken the way Hill House was in Jackson's novel. Then, a question arises: Whose voice is it on those tapes?

More happens in Anatomy's short run time, but summarizing it here would be to the game's detriment. But know this: What makes Anatomy feel vital four years after its release is the sense that it wants to welcome you into horror at the same time as it plays with horror storytelling. It pushes you to think about why scary things are scary, what deeper psychology is at work when you're afraid of the dark room at the end of the hall or what might be behind that locked door.

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Anatomy Opens the Creaking Door to Haunted House Tales - WIRED

Anatomy of the ‘Hit Machine,’ the greatest duo Emraan Hashmi and KK – The Indian Wire

Forgive me if Im wrong, as I am expressing myself on the behalf of an entire generation of people who grew up listening to Emraan Hashmi songs, most of them which were sung by KK. I am writing it down assuming that almost all of us have these same memories relating to these songs of this hit duo.

Back when we were kids and we never intentionally heard or searched for these songs, these tunes just submerged into our ears directly via radios at a school canteen or maybe your elder siblings/ cousins listening to them on TV. The tunes were so catchy that it probably got sucked by our unconscious minds. A time when movies and songs meant nothing to us, we were either playing all the time and partially studying.

As time passed further, we were enjoying our last couple of years in school. Sharing Games and Music via Blank CDs or Bluetooth Transfers. The attraction might be the first of all the feelings that we experienced, and it was that stage in our life. From animated channels we had shifted to music channels, the music we heard back then was now on the recall path.

Many of these songs from Emraans films were a part of Bluetooth transfers as we used our dads handsets. Being occupied with school, sports, tuitions, etc. the days passed by, these songs became a part of our life. As we were in the midst of understanding this term attraction which we never really understood and didnt even need to. Yet we enjoyed those new feelings in a way through these songs Zara Si, Soniyean endless list.

Now as of today, these songs might act as a highlight to all the memories and the tons of stories you were a part of. A time which might have been different for all of us, our stories and memories might differ but in a way, they are connected through some of these beautiful elements of various mediums.the Beetein Lamhein

Share your views and stay tuned to The Indian Wire for more such articles and analysis.

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Anatomy of the 'Hit Machine,' the greatest duo Emraan Hashmi and KK - The Indian Wire

Global Ear Anatomical Model Market Understanding the Industry You Are Entering Its Size, Attractiveness and Profit Potential – Aerospace Journal

Ear Anatomical Model Market Industry Forecast To 2026

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The novel COVID-19 pandemic has put the world on a standstill, affecting major operations, leading to an industrial catastrophe. This report presented by Garner Insights contains a thorough analysis of the pre and post pandemic market scenarios. This report covers all the recent development and changes recorded during the COVID-19 outbreak.

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Major Manufacturer Detail:Erler-Zimmer Anatomiemodelle, GPI Anatomicals, Nasco, RuDIGER ANATOMIE, SOMSO, Xincheng Scientific Industries Co., Ltd., YUAN TECHNOLOGY LIMITED, ltay Scientific, Columbia Dentoform, Denoyer-Geppert, Educational + Scientific Products Ltd

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North America (U.S and Canada and Rest of North America)Europe (Germany, France, Italy and Rest of Europe)Asia-Pacific (China, Japan, India, South Korea and Rest of Asia-Pacific)LAMEA (Brazil, Turkey, Saudi Arabia, South Africa and Rest of LAMEA)

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1. An overall outlook of the market that helps in picking up essential data.2. The market has been segmented on the basis of the product types, applications, end-users, as well as the industry verticals, in light of numerous factors. Considering the market segmentation, further analysis has been carried out in an effective manner. For better understanding and a thorough analysis of the market, the key segments have further been partitioned into sub-segments.3. In the next section, factors responsible for the growth of the market have been included. This data has been collected from the primary and secondary sources and has been approved by the industry specialists. It helps in understanding the key market segments and their future trends.4. The report also includes the study of the latest developments and the profiles of major industry players.5. The Ear Anatomical Model market research report also presents an eight-year forecast on the basis of how the market is predicted to grow.

View Full Report @ https://garnerinsights.com/COVID-19-Version-Global-Ear-Anatomical-Model-Market-Status-2015-2019-and-Forecast-2020-2025-by-Region-Product-TypeEnd-Use

About Us:Garner Insights is a Market Intelligence and consulting firm with an all-inclusive experience and vast knowledge of the market research industry.Our vast storage of research reports across various categories, gives you a complete view of the ever changing and developing trends and current topics worldwide. Our constant endeavor is to keep on improving our storage information by providing rich market reports and constantly improving them.

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Global Ear Anatomical Model Market Understanding the Industry You Are Entering Its Size, Attractiveness and Profit Potential - Aerospace Journal

‘Grey’s Anatomy’: The Heartbreaking Episode That Hits Almost Too Close to Home in 2020 – Showbiz Cheat Sheet

The medical drama Greys Anatomy has often been criticized for having an unrealistic portrayal of the medical work that goes on in a hospital.

While the show does demonstrate that the writers research the medical conditions and treatments that appear in each episode, things are often exaggerated to increase the level of drama on the show.

That being said, the character dynamics and emotions expressed on the show are intricate and very human, and when the writers are able to weave together an interesting medical plot with expert characterization and plot crafting, fans and critics alike are eager to dissect and share their responses to the show.

Sometimes, episodes of Greys Anatomy really resonate with something going on in the real world. Greys Anatomy has tackled subjects like abortion, police brutality, and sexual assault.

But in 2020, theres one episode of Greys Anatomy that is especially resonant. So what episode are fans pointing to as especially relevant in 2020? And what makes it hit so close to home?

The show Greys Anatomy is one of the longest running dramas on TV. It centers around the medical staff of a Seattle hospital, their work, and their interpersonal relationships.

The writing of the show has been praised by fans and critics alike, and the show has earned several awards. Its also had an impact on other TV shows and fan culture, from jokes that have spread out from the Greys Anatomy fandom to montage styles that have been copied by other shows. Its clear: the production team of Greys Anatomy created a veritable phenomenon.

And since Greys Anatomy is so huge, it therefore has a thriving fan community. On forum sites like Reddit and fanfiction sites like Archive of Our Own, theGreys Anatomyfandom shares much discussion and transformative work based on this show.

RELATED: Greys Anatomy: 1 of Aprils Best Scenes Was Also 1 of the Most Tragic

In a Reddit on the Greys Anatomy subreddit, fans discussed the season six episode The Time Warp, and how resonant it is in the midst of the COVID-19 pandemic.

The episode is structured around various flashbacks that the main characters are having about how they began their medical careers. One physician reminisces about treating a patient with AIDS in the early 1980s, and the fear and uncertainty that came around treating a patient with HIV before much was known about the condition.

Because HIV/AIDS was still relatively uncommon in 1982 and under-researched, the show portrays the doctors as being extremely cautious about contact with the patient for fear to contracting the disease.

One reddit user pointed out there are parallels between the AIDS epidemic of the 1980s and the COVID-19 pandemic today, and that this episode reminded them of this:

I have older nurse friends who say the Covid-PPE in ICUs reminds them of the AIDS-PPE they used in the 80s & 90s. Its been heartbreaking to know of Covid patients dying alone in isolation rooms with no skin-to-skin hand-holding or physical contact in their last moments, suffering the same fate as early AIDS patients. The AIDS crisis changed the way we viewed hospice, perhaps the Covid crisis will change the way we handle isolation and infection control.

This isnt the only way that Greys Anatomy has been relevant in the COVID-19 pandemic.

Though the show had to stop filming due to the pandemic, it will likely discuss the pandemic in the upcoming season.

But on top of that, Greys Anatomy, along with a few other popular medical dramas, donated large amounts of PPE to hospitals in need. Because things like N95 masks are used as props, the show had enough that hadnt been used that they were able to donate.

Beyond tackling societal issues in fiction, then, Greys Anatomy became a part of the national response to the COVID-19 pandemic.

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'Grey's Anatomy': The Heartbreaking Episode That Hits Almost Too Close to Home in 2020 - Showbiz Cheat Sheet

Check Out the Dramatic Newly Released Crossover Trailer for ‘Grey’s Anatomy’ and ‘Station 19’ – AmoMama

A new shocking and jaw-dropping teaser has been released for the much-anticipated premiere of the "Grey's Anatomy" and "Station 19" crossover, which is set to hit the screens on November 12.

With just three weeks before fans of the beloved ABC dramas "Grey's Anatomy" and "Station 19" get to see the three-hour crossover premiere event, the network has released a captivatingteaser to whet fans' appetites.

In the 30 seconds promo clip, fans get to have a look at what to expect as the doctors and firefighters respond to the ongoing COVID-19 pandemic, which would be explored. It began with a scene of Meredith Grey, played by Ellen Pompeo in complete personal protective equipment, which includes a face shield.

Looking stressed and desperate, Grey stands in the middle of Grey Sloan Memorial Hospital with her together as if offering a prayer while she says, "sometimes we all need saving." It followed by a dramatic frame of Miranda Bailey, played by Chandra Wilson, looking through the glass and asking for a miraculous intervention.

Scenes from "Station 19" then come into play before there is an alternation between both shows. It is, however, the ending of the teaser that is the highlight of the promo as the background voice assures viewers that the premier would leave everyone shocked and saying, "Oh my god."

Season 17 of the medical series was first teased last month when Pompeo shared a photo of the crew on the first day on set after returning following the halt the pandemic brought to productions.

Before the image, Pompeo's co-star Giacomo Gianniotti confirmed that the new season would take off a bit farther from where things stopped in the previous season.

Its firefighter spin-off is set to return for its fourth season and explore the shocking revelation that Andy's mother, Elena, is not dead but alive. The show explores the lives and careers of the firefighters at the Seattle Fire Station 19, which is about three blocks away from Grey Sloan Memorial Hospital.

"Station 19" is the second spin-off of the award-winning "Grey's Anatomy," with the first being "Private Practice." The crossover would see Ben Warren, played by Jason George, and Andy Herrera, by Jaina Lee Ortiz, visit the hospital after a rescue mission that saved two boys from a house fire.

They take the boys for surgery and Warren who is a doctor turned firefighter is tasked with the decision to help out while Herrerra's hand remains in the victim's abdomen to stop him from bleeding.

Both shows premiere on November 12 with "Station 19" taking the lead at 8 pm and "Grey's Anatomy" coming in shortly by 9 pm. Other ABC shows set to premiere next month include "Good Doctor" on November 2, "Big Sky," on November 17, followed by "For Life" on November 18.

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Check Out the Dramatic Newly Released Crossover Trailer for 'Grey's Anatomy' and 'Station 19' - AmoMama

Grey’s Anatomy: Meredith’s Transformation Over The Years (In Pictures) – Screen Rant

Grey's Anatomy fans have watched Meredith's struggles and triumphs for so long, they may not realize just how much she has changed.

Meredith Grey from the hit medical drama Grey's Anatomy has become one of the most iconic television characters for over a decade and a half.

RELATED:Grey's Anatomy 5 Most Likable Characters (& 5 Fans Can't Stand)

Grey's has had an overwhelming spate of ups and downs throughout its run, but it was its central character Meredithwho changed the most over the course of the series. Having started out as a slightly superficial young woman, she went on to become a powerhouse of strength and a brilliant surgeon.

Meredith was first introduced as an attractive young woman just starting out as an intern at Seattle Grace Teaching Hospital. She was a bit green and lost and wasn't entirely sure she had made the right decision with regard to her profession.

She was also a tad whiny, and very selective about the kind of roommates she wanted, being rather obstinate, even to the point of being annoying. She was clearly smitten with McDreamy and had every right to be angry when she found out about his wife, Addison Montgomery-Shepherd, but she lacked the gravityat the time to deal with it more maturely.

Meredith got together with Derek Shepherd and continued to make small strides in her career as she went from being a surgical intern to a resident at the hospital. Her attachmentwith Cristina gradually grewstrongergoing on to become something of a legendary friendship on popular television.

Meredith overcomesher mother's death at this time and settles into her life as a budding surgeon and as the impressive neurosurgeon's girlfriend.

In season 5, Meredith takes a big step when she decides to marry Derek, and true to their style, the two write their marriage vows down on a post-it. The unpretentious wedding speaks to the couple's modest philosophy of life, in spite of Derek being quite well-off himself.

RELATED:Grey's Anatomy: 5 Times Meredith And Derek Were The Perfect Couple (& 5 Times They Weren't)

Fans might remember that season 6 ended with Derek being shot and operated on, at gunpoint, by Cristina Yang. Meredith had a major trauma at the time as she saw her husband being almost killed and lost her baby at the same time. In hindsight, this might have been the season she grew up in.

In seasons 7 and 8, Meredith made some crucial choices in her life, when she decided to risk her career and reputation as well as that of Derek's by disrupting the Alzheimer's trial. However, debatable as the step was, it came from a place of deep loyalty and fondness for Richard, the only father figure in Meredith's life.

Meredith and Derek also decided to adopt baby Zola, which was a huge step for them both. This was the time that Meredith went on to take on bigger responsibilities,

Season 8 had ended with the devastating plane crash that caused the death of Meredith's young sister Lexie and Dr. Mark Sloan.

The disaster was one of the biggest tragedies Meredith had seen in her life and she had seen more than her fair share. She pulled it together slowly and managed to turn her life around after the incident, becoming one of the owners of Seattle Grace which then went on to be known as Grey Sloan Memorial, in honor of those who had died in the tragedy. She also had her first baby in this season in complete darkness and managed to pull through despite having a complicated birth.

The tragedy of season 9 had made Meredith stronger somehow and with a heavy heart, she managed to let Cristina go when the latter decided to take a prestigious job in Switzerland.

RELATED:Grey's Anatomy: Why Meredith & Cristina Aren't Real Friends

It would have taken a lot of strength for Meredith to come to terms with losing her best friend, her 'person' who had been by her side through thick and thin.

Season 11 was the most devastating to date for Meredith Grey. Not only did she start having difficulties in her marriage with Derek, and take the decision to stay back in Seattle where she had her own life and career, she lost Derekafter he died in a car accident.

Another episode in her life when Meredith found herself all alone, in spite of having friends who looked out for her, the widowed mother of two gave birth to Derek's posthumousbaby alone. Time stopped for her until she had found the motivation to come back to her old life. With that one incident, Meredith grew a few years in age and maturity.

Meredith went on to struggle with life, now as a single mother of three. She also showed extraordinary power when she was able to forgive the woman, Penny, whom she held somewhat responsible for mishandling her husband's treatment.

She threw herself into work, now one of the most reliable and topsurgeons in the hospital. Every trauma from her past had made her stronger and more mature in life and as a person.

Meredith went on to win the prestigious Harper Avery award, an award her mother Ellis Grey had won twice.

Meredith also tried to move on after Derek's death, finally allowing herself to date other men, whether the dashing new surgeon Nathan Riggs or the handsome new surgical intern Andrew DeLuca.

By season 15 and 16, Meredith has had some of the most amazing surgeries to her credit and had probably saved more lives than she could remember.

Her years of hard work were also validated when all her past patients came to speak up on her behalf during the trial to reinstate her medical license in season 16. Meredith grew steadily more strong and independent over the years, although she still retained her impulsive behavior, when she decided to commit insurance fraud to make life easier for one of her patients, leading to her license being revoked in the first place.

NEXT:Grey's Anatomy: 10 Most Shameless Things Meredith Ever Did (& Should Be Proud Of)

Next The Last Airbender: 10 People Zuko Could Have Been With (Other Than Mai)

Surangama, or Sue, as she is called by many, has been writing on films, television, literature, social issues for over a decade now. A teacher, writer, and editor, she loves nothing better than to curl up on a lazy afternoon with her favorite book, or with a pen and a notebook (a laptop would have to do!) and a foaming cuppa tea on the side.

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Grey's Anatomy: Meredith's Transformation Over The Years (In Pictures) - Screen Rant

Skull Anatomical Model Market Size Status and Global Outlook 2020 to 2025 – The Think Curiouser

The Global Skull Anatomical Model Market report provides an in-depth analysis of the key market insights, its future trends, and developments, profiles of leading players, key restraints and drivers, segmentation, and forecasting. The report highlights the market size and CAGR of the important segments, thus providing quick relevant information on the global market. The report consists of several aspects that affect the growth of the Skull Anatomical Model market. It also offers an excellent growth opportunity for the new entrants and assisting them to get more profit.

This study especially analyses the impact of the Covid-19 outbreak on the Skull Anatomical Model, covering the supply chain analysis, impact assessment to the Skull Anatomical Model market size growth rate in several scenarios, and the measures to be undertaken by Skull Anatomical Model companies in response to the COVID-19 epidemic.

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The report also presents the market competition landscape and a corresponding detailed analysis of the major vendors/manufacturers in the market. The key manufacturers covered in this report:

GF Dental, Navadha Enterprises, SOMSO, Xincheng Scientific Industries Co., Lt, YUAN TECHNOLOGY LIMITED, GPI Anatomicals, 3B Scientific, 3M ESPE, Altay Scientific, Educational + Scientific Products Ltd, Erler-Zimmer Anatomiemodelle

Regional and Country-level Analysis

The report offers an exhaustive geographical analysis of the global Skull Anatomical Model market, covering important regions, viz, North America, Europe, China, and Japan. It also covers key countries (regions), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, U.A.E, etc.

The report includes a country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by each application segment in terms of sales for the period 2015-2026.

Strategic Points Covered in TOC:

The report firstly introduced the Incubator basics: definitions, classifications, applications, and market overview; product specifications; manufacturing processes; cost structures, raw materials, and so on. Then it analyzed the worlds main region market conditions, including the product price, profit, capacity, production, supply, demand, and market growth rate and forecast, etc. In the end, the report introduced a new project SWOT analysis, investment feasibility analysis, and investment return analysis. The Skull Anatomical Model Market report is a collection of pragmatic information, quantitative and qualitative estimation by industry experts, the contribution from industry connoisseurs and industry accomplices across the value chain. Furthermore, the report also provides the qualitative results of diverse market factors on its geographies and segments

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Skull Anatomical Model Analysis and Strategies Carry Out as below:

Note: All the reports that we list have been tracking the impact of COVID-19 on the market. Both upstream and downstream of the entire supply chain has been accounted for while doing this. Also, where possible, we will provide an additional COVID-19 update supplement/report to the report in Q3, please check for with the sales team.

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Skull Anatomical Model Market Size Status and Global Outlook 2020 to 2025 - The Think Curiouser

Modelling the Anatomical Distribution of Neurological Events in COVID-19 Patients: A Systematic Review – DocWire News

This article was originally published here

medRxiv. 2020 Oct 23:2020.10.21.20215640. doi: 10.1101/2020.10.21.20215640. Preprint.

ABSTRACT

BACKGROUND: Neuropathology caused by the coronavirus disease 2019 (COVID-19) has been reported across several studies. The characterisation of the spatial distribution of these pathology remains critical to assess long and short-term neurological sequelae of COVID-19. To this end, Mathematical models can be used to characterise the location and aetiologies underlying COVID-19-related neuropathology.

METHOD: We performed a systematic review of the literature to quantify the locations of small neurological events identified with magnetic resonance imaging (MRI) among COVID-19 patients. Neurological events were localised into the Desikan-Killiany grey and white matter atlases. A mathematical network diffusion model was then used to test whether the spatial distribution of neurological events could be explained via a linear spread through the structural connectome of the brain.

FINDINGS: We identified 35 articles consisting of 123 patients that assessed the spatial distribution of small neurological events among COVID-19 patients. Of these, 91 patients had grey matter changes, 95 patients had white matter changes and 72 patients had confirmed cerebral microbleeds. White matter events were observed within 14 of 42 white matter bundles from the IIT atlas. The highest proportions (26%) of events were observed within the bilateral corticospinal tracts. The splenium and middle of the corpus callosum were affected in 14% and 9% of the cases respectively. Grey matter events were spatially distributed in the 41 brain regions within the Desikan-Killiany atlas. The highest proportions (10%) of the events were observed in areas including the bilateral superior temporal, precentral, and lateral occipital cortices. Sub-cortical events were most frequently identified in the Pallidum. The application of a mathematical network diffusion model suggested that the spatial pattern of the small neurological events in COVID-19 can be modelled with a linear diffusion of spread from epicentres in the bilateral cerebellum and basal ganglia (Pearsons r =0.41, p <0.001, corrected).

INTERPRETATION: To our knowledge, this is the first study to systematically characterise the spatial distribution of small neurological events in COVID-19 patients and test whether the spatial distribution of these events can be explained by a linear diffusion spread model. The location of neurological events is consistent with commonly identified neurological symptoms including alterations in conscious state among COVID-19 patients that require brain imaging. Given the prevalence and severity of these manifestations, clinicians should carefully monitor neurological symptoms within COVID-19 patients and their potential long-term sequelae .

PMID:33106811 | PMC:PMC7587784 | DOI:10.1101/2020.10.21.20215640

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Modelling the Anatomical Distribution of Neurological Events in COVID-19 Patients: A Systematic Review - DocWire News

Ear Anatomical Model Market : In-depth Analysis to Understand the Competitive Outlook of the Global Industry with Future Estimations – Eurowire

Market Overview of Ear Anatomical Model Market

The Ear Anatomical Model market report provides a detailed analysis of global market size, regional and country-level market size, segmentation market growth, market share, competitive Landscape, sales analysis, impact of domestic and global market players, value chain optimization, trade regulations, recent developments, opportunities analysis, strategic market growth analysis, product launches, area marketplace expanding, and technological innovations.

The global Ear Anatomical Model market size is expected to gain market growth in the forecast period of 2020 to 2025, with a CAGR of xx%% in the forecast period of 2020 to 2025 and will expected to reach USD xx million by 2025, from USD xx million in 2019.

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Market segmentation

Ear Anatomical Model market is split by Type and by Application. For the period 2015-2025, the growth among segments provide accurate calculations and forecasts for sales by Type and by Application in terms of volume and value. This analysis can help you expand your business by targeting qualified niche markets.

Segment by Type, the Ear Anatomical Model market is segmented intoChildren Anatomical ModelAdult Anatomical Model

Segment by Application, the Ear Anatomical Model market is segmented intoHospitalClinicMedical College

Regional and Country-level AnalysisThe Ear Anatomical Model market is analysed and market size information is provided by regions (countries).The key regions covered in the Ear Anatomical Model market report are North America, Europe, Asia Pacific, Latin America, Middle East and Africa. It also covers key regions (countries), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, U.A.E, etc.The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by Type, and by Application segment in terms of sales and revenue for the period 2015-2026.

Regional analysis is another highly comprehensive part of the research and analysis study of the global Ear Anatomical Model market presented in the report. This section sheds light on the sales growth of different regional and country-level Ear Anatomical Model markets. For the historical and forecast period 2015 to 2025, it provides detailed and accurate country-wise volume analysis and region-wise market size analysis of the global Ear Anatomical Model market.

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The report offers in-depth assessment of the growth and other aspects of the Ear Anatomical Model market in important countries (regions), including:

North America (United States, Canada and Mexico)

Europe (Germany, France, UK, Russia and Italy)

Asia-Pacific (China, Japan, Korea, India and Southeast Asia)

South America (Brazil, Argentina, etc.)

Middle East & Africa (Saudi Arabia, Egypt, Nigeria and South Africa)

Ear Anatomical Model competitive landscape provides details by vendors, including company overview, company total revenue (financials), market potential, global presence, Ear Anatomical Model sales and revenue generated, market share, price, production sites and facilities, SWOT analysis, product launch. For the period 2015-2020, this study provides the Ear Anatomical Model sales, revenue and market share for each player covered in this report.

Competitive Landscape and Ear Anatomical Model Market Share AnalysisEar Anatomical Model market competitive landscape provides details and data information by players. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on revenue (global and regional level) by players for the period 2015-2020. Details included are company description, major business, company total revenue and the sales, revenue generated in Ear Anatomical Model business, the date to enter into the Ear Anatomical Model market, Ear Anatomical Model product introduction, recent developments, etc.The major vendors covered:Erler-Zimmer AnatomiemodelleGPI AnatomicalsNascoRuDIGER ANATOMIESOMSOXincheng Scientific Industries Co., Ltd.YUAN TECHNOLOGY LIMITEDltay ScientificColumbia DentoformDenoyer-GeppertEducational + Scientific Products Ltd

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The content of the study subjects, includes a total of 15 chapters:

Chapter 1, to describe Ear Anatomical Model product scope, market overview, market opportunities, market driving force and market risks.

Chapter 2, to profile the top manufacturers of Ear Anatomical Model, with price, sales, revenue and global market share of Ear Anatomical Model in 2018 and 2019.

Chapter 3, the Ear Anatomical Model competitive situation, sales, revenue and global market share of top manufacturers are analyzed emphatically by landscape contrast.

Chapter 4, the Ear Anatomical Model breakdown data are shown at the regional level, to show the sales, revenue and growth by regions, from 2015 to 2020.

Chapter 5, 6, 7, 8 and 9, to break the sales data at the country level, with sales, revenue and market share for key countries in the world, from 2015 to 2020.

Chapter 10 and 11, to segment the sales by type and application, with sales market share and growth rate by type, application, from 2015 to 2020.

Chapter 12, Ear Anatomical Model market forecast, by regions, type and application, with sales and revenue, from 2020 to 2025.

Chapter 13, 14 and 15, to describe Ear Anatomical Model sales channel, distributors, customers, research findings and conclusion, appendix and data source.

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Ear Anatomical Model Market : In-depth Analysis to Understand the Competitive Outlook of the Global Industry with Future Estimations - Eurowire

Uterine environment ‘as important as the embryo’ in affecting implantation and pregnancy – ESHRE

An online Campus meeting held in October reviewed the diagnosis of uterine abnormalities and the minimally invasive surgical - and emerging medical - approaches in their management ahead of fertility treatment.

Growths, chronic inflammation and other abnormalities affecting the womb such as congenital malformations are all implicated in IVF failure, miscarriage and premature labour. This makes the uterine environment as important as the embryo in determining fertility outcomes.

The speakers at this first Autumn online Campus meeting in October, organised by the SIG Reproductive Surgery, emphasised how diagnosis and treatment of these often chronic conditions have advanced, with minimally invasive techniques to preserve the uterus - such as hysteroscopy - now widely available. But evidence is still lacking of efficacy in improving pregnancy rate, consensus has yet to be reached on the best diagnostic approaches and classification of anomalies is still proving a challenge.

Myomectomy is the most evidence-based approach for fibroid removal, with studies showing a pregnancy rate of up to 68% in patients who otherwise face poor IVF outcomes, possibly as a result of uterine cavity distortion, and poor implantation success. Attila Vereczkey, president of the Hungarian Human Reproduction Society, told the online audience that hysteroscopy is the preferred excision method. High-intensity focused ultrasound and uterine artery embolisation are among experimental management strategies and not yet recommended as front-line treatment. Vereczkeys take-home message was to follow the rules: get informed consent, map fibroids, plan surgery and explore minimally invasive techniques where possible.

A lack of randomised controlled trial evidence means no gold standard yet exists for adenomyosis treatment is always case-by-case, especially for cytoreductive techniques. An easy-looking fibroid can be hard, and a difficult one easy, was how Antoine Watrelot summed up the situation, highlighting how diagnosis can be challenging despite MRI and ultrasound. A recent review has indicated that pregnancy rates for focal adenomyosis patients appear to be higher after conservative surgery compared with diffuse adenomyosis (53% vs 34%) but more trials are needed to prove benefit.(1)

Bela Molnar discussed the challenges of managing patients with congenital uterine malformations such as bicornate uteri. Once again, hysteroscopy is the treatment of choice based on reproductive results and other factors, but who to treat and how many times remains a dilemma - and the aim of restoring normal uterine architecture is not always possible, said Molnar.

For subfertile women with minor abnormalities or subtle lesions of the endometrial cavity, hysteroscopy appears to be of potential benefit, yet multicentre study evidence is limited because the procedure works with images, and images can be misleading. So said Stephan Gordts, adding that diagnosis can also be hampered by a lack of uniform terminology to describe these unsuspected intrauterine pathologies which have an hysteroscopy discovery rate of between 25 and 56%.

The picture is similar for hysteroscopy in the assessment of chronic endometritis, which is a significant cause of recurrent miscarriage (9-43%) and repeat failed IVF (14-56%). Although seen as a gamechanger, the diagnostic accuracy of office hysteroscopy using fluid media has varied widely across studies, prompting attempts to reach consensus on the endometrial features of chronic endometritis.(2) Checking for chronic endometritis remains vital, according to Sergio Haimovich, as underlined by his own clinics 40% positive rate. As for treatment, a simple regime of doxycycline (200 mg daily for 14 days) can decrease abortion and increase implantation rates for chronic endometritis patients, outcomes yet to be corroborated by well-designed prospective studies.

The current thinking is that chronic endometritis may be caused by a variety of reproductive tract microbiota. Evidence presented by Andrea Bernabeu suggests an association between chronic endometritis and significantly higher abundance of 18 bacterial taxa in the endometrial cavity, and that endometrial microbiota affect ART implantation success/failure.

The question is, could an abnormal microbiome be cured? Science does not yet have an answer. Research on antibiotic use is inconclusive, said Bernabeu, and also on probiotics, although the latter do appear to modify the pattern of expression in vaginal microbiota.

1 Tan J, Moriarty S, Taskin O, et al. Reproductive outcomes after fertility-sparing surgery for focal and diffuse adenomyosis: A systematic review. J Minim Invasive Gynaecol 2018; 25; 608-621. doi.org/10.1016/j.jmig.2017.12.0202 Cicinelli E, Vitagliano A, Kumar A, et al. Unified diagnostic criteria for chronic endometritis at fluid hysteroscopy: proposal and reliability evaluation through an international randomized-controlled observer study. Fertil Steril 2019; 112; 162-173. doi:10.1016/j.fertnstert.2019.03.004

uterusendometrial abnormalitieschronic endometritisfibroidshysteroscopyimplantation

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Uterine environment 'as important as the embryo' in affecting implantation and pregnancy - ESHRE

Beijing+25: where are we now, and where do we go next? – World Health Organization

Special series aims to advance womens health and gender equality.

Progress on gender equality has been made in all 12 key areas identified in the 1995 Beijing Declaration and Platform for Action on Women - but for millions of girls and women around the world today, this visionary agenda is still far from reality.

The British Medical Journal (BMJ) has commissioned a special series of papers on Womens Health and Gender Inequalities with support from the World Health Organization (WHO), the Human Reproduction Programme (HRP) and theUnited Nations University International Institute for Global Health (UNU-IIGH).

Launched at the World Health Summit, the series reflects on priorities articulated twenty-five years ago for improving womens health, and asks: what has been learned, and what still needs to change?

The Beijing Declaration affirmed that womens rights are human rights and that gender equality is an essential building block for health, well-being, development and peace.

The topics covered in the BMJ series, include a broad range of social and medical factors influencing womens health, such as sexual and reproductive health; violence against women, mental health,noncommunicable diseases, climate change, limited inclusion of women inclinical research and the role of the feminist movement in womenshealth.

This series also includes a co-authored opinion piece by WHO Director-General Dr Tedros Adhanom Ghebreyesus.

Progress in womens health remains fragile and uneven. While progress has been made in reducing maternal mortality and harmful gender practices such as female genital mutilation, millions of women stillcontinue to have an unmet need for contraception.

Rising rates of reproductive cancers, mental ill-health, non-communicable diseases and new disease outbreaks including Ebola, Zika and COVID-19, are highlighting the need to have a comprehensive approach to womens health throughout their life-course.

While there is a greater recognition of women as providers of healthcare, many face an unacceptable level of harassment, violence and abuse in the workplace.

Access to health services for millions of women remains limited even as countries are moving to a progressive realization of universal health coverage. In part, this is linked to an emphasis on employment-based health financing, which excludes women,who tend to work in informal sectors.

In the midst of tracking progress on the Beijing Declaration, the COVID-19 pandemic is limiting or reversing gains made towards gender equality. While women and men seem to be infected by COVID-19in roughly equal numbers, women health workers, whoare the majority of frontline providers, are at increased risk of infection.

COVID-19 has brought rising economic insecurity, driving millions, especially women who work in informal sectors, into unemployment. Lockdown measures have increased the already high burden of unpaid care work shouldered by women, including caring forchildren, the sick, and the elderly. And distancing measures have increased violence against womenand children a widespread issue even before the pandemic.

Many governments are reprioritizing what health services are provided in the context of COVID-19 and unfortunately scaling back access to essential services for women- including comprehensive sexual and reproductive health care, which includes servicesfor survivors of violence.

WHO Director-General Tedros Adhanom Ghebreyesus, Executive Director of UN Women Phumzile Mlambo-Ngcuka, and Rector of UN University David Malone, argue in their opinion piece that, Covid-19 provides an opportunity to re-imagine a future where womenshealth and rights are non-negotiable, gender equality is achievable and working towards it is the norm.

The health, well-being and needs of half the worlds population cannot be treated as an afterthought. Investing in womens health is a moral and smart imperative. It saves lives, reduces poverty, increases productivity and stimulates economicgrowth with up to a nine-fold return on investment.

WHO is committed to the Beijing Declaration and is marking the 25th anniversary with a number of activities.

Learn more about our involvement in Beijing+25.

Read the BMJ series. Additional papers will be added inMarch 2021

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Beijing+25: where are we now, and where do we go next? - World Health Organization

Mice Model Market Is Predicted to Witness A Massive Growth Up To 2025 – Illadel Graff Supply

Global mice model market is deriving massive growth from towering adoption of mice models for various research investigations. Rising prevalence of cancer, autoimmune disorders, and cardiovascular diseases are prompting various research studies. Mice possess almost 95% genetic similarity with humans due to which they are among the most preferred models for understanding the mechanism and cause of diseases occurring in humans. Mice models are widely used as basic models for the study of human reproduction.

Mice models are extensively used in research and development activities to assess the efficacy and safety of new vaccines and drugs. In 2018, the research & development segment was accounted for 71% of the overall mice model market share. Notably, biotech and pharma companies have been focused on R&D activities to come up with novel treatments

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Based on mice type, mice model market is segmented into outbred, inbred, hybrid, knockout, and others. In 2018, inbred mice model industry held the maximum share of over 27%. These models are experiencing heavy demand from cancer research programs as mice models are designed for the testing of compounds, that manipulate the immune system to assist in fighting cancer. Inbred mice models also aid researchers in understanding the mechanism of disease.

Based on technology, the mice model market is classified into CRISPR, embryonic stem cell, microinjection, nuclear transfer, and others. The CRISPR technology market was held for a market share of around 32.7% in 2018. Aspects like cost-effectiveness, time saving, and ease of use has encouraged technology adoption.

Speaking in terms of usage, mice model market is segmented into veterinary and human. The human segment dominated the global market in 2018 with over 80% share. For understanding the mechanism of deadly diseases, such as diabetes, cancer and cardiovascular diseases, which result in loss of millions of lives every year, the number of testing procedures on mice models is escalating. Moreover, widespread utilization of these models for understanding the biological behavior of neurological disorders and autoimmune diseases is likely to boost segmental growth.

On the regional front, the U.S. is expected to offer lucrative growth opportunities to the mice model industry. There are number of research being conducted in the region, primarily for findings treatments for metabolic disorders, cardiovascular disease, and cancer. As mice are genetically similar to humans, organizations in the U.S. mostly preferring using these models in their clinical studies.

Key industry players operating in the mice model industry include genOway, Envigo, Charles River, Janvier Labs, Transviragen Inc., Transpogen Biopharmaceutical, Inc., and Taconic Biosciences Inc.

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Partial Chapter of the Table of Content

Chapter 4. Mice Model Market, By Mice Type

4.1. Key segment trends

4.2. Inbred

4.2.1. Market estimates and forecast, by region, 2014 2025 (USD Million)

4.2.2. Market estimates and forecast, by region, 2014 2025 (Units)

4.3. Outbred

4.3.1. Market estimates and forecast, by region, 2014 2025 (USD Million)

4.3.2. Market estimates and forecast, by region, 2014 2025 (Units)

4.4. Knockout

4.4.1. Market estimates and forecast, by region, 2014 2025 (USD Million)

4.4.2. Market estimates and forecast, by region, 2014 2025 (Units)

4.5. Hybrid

4.5.1. Market estimates and forecast, by region, 2014 2025 (USD Million)

4.5.2. Market estimates and forecast, by region, 2014 2025 (Units)

4.6. Others

4.6.1. Market estimates and forecast, by region, 2014 2025 (USD Million)

4.6.2. Market estimates and forecast, by region, 2014 2025 (Units)

Chapter 5. Mice Model Market, By Technology

5.1. Key segment trends

5.2. CRISPR

5.2.1. Market estimates and forecast, by region, 2014 2025 (USD Million)

5.3. Microinjection

5.3.1. Market estimates and forecast, by region, 2014 2025 (USD Million)

5.4. Embryonic Stem Cell Injection

5.4.1. Market estimates and forecast, by region, 2014 2025 (USD Million)

5.5. Nuclear Transfer

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Mice Model Market Is Predicted to Witness A Massive Growth Up To 2025 - Illadel Graff Supply