‘Grey’s Anatomy’: Why Camilla Luddington Originally Thought Her Role on the Show Was Not ‘Meant to Be’ – Showbiz Cheat Sheet

Greys Anatomy star Camilla Luddington is now in her 9th season as the fan-favorite Dr. Jo Karev, and shes still going strong. Theres a possible romance blossoming between Jo and Jackson Avery (Jesse Williams), and Luddington promises that her character has a big revelation this season about her career. But, she also admits that she originally thought her role on Greys wasnt meant to be.

Luddington says that after eight seasons on Greys Anatomy, one of her favorite things about working on the show is that the actors dont know everything about their characters.

Its really exciting playing a character that every season you learn something new about. I didnt know that she was married before and I didnt know that she was in an abusive relationship; I didnt even know that she was homeless until, I think, episode 8, maybe, of my first season, Luddington told Backstage.

She explained that she feels like shes constantly learning new and exciting things about her character. Luddington says that when you sit with a character for this long, you get to be on a journey of growth with them. Not only does she get to experience Jos heartbreak and pain, but also her happiness, her wins, and her losses.

Luddington notes that the experience is really amazing. She also admitted that she was surprised by Jos big career revelation in season 17. And, shes really excited to play it.

The actress says that she came close to losing out on the role of Jo, but she turned things around rather quickly. Luddington recalled that she was at San Diego Comic-Con in 2012 because of her gig as the voice of Lara Croft in Tomb Raider.

She remembers it was a Friday, and her agent told her, Its such a shame because Shonda [Rhimes] really wants you to audition for a new intern class for Greys Anatomy.

RELATED: Greys Anatomy Star Ellen Pompeo Reveals COVID-19 Made 1 Positive Change to the TV Industry

Luddington noted that all of the auditions were on that Friday when she was in San Diego, and she just thought to herself, OK, well, its not meant to be. But the next day, she found out that Rhimes didnt find what she wanted during the Friday audition. As a result, she was bringing five girls in on Monday.

And so I was doing Comic-Con and quickly learning my doctor dialogue, Luddington recalls. And then went in on the Monday, heard on Wednesday that I had it, and then I started work on the Friday.

After Jos tumultuous season 16, fans were looking forward to seeing the direction the character would take this season. In the premiere, they got a huge shock when Jo asked Jackson for a sex favor, even though the two had never even flirted in the past. Luddington admits that when she read the script, she couldnt stop laughing.

Honestly, Jesse and I, we get along really well. We laugh a lot together anyway. But we dont necessarily work together a lot, and for a long time now, Ive been asking to work together. So, when these scenes hit, we thought it was hysterical. I was excited to film it, because I also loved that Jo was putting herself out there, Luddington told Good Housekeeping.

She also looked back at the controversial breakup between Jo and Alex Karev, which was the result of Justin Chambers real-life exit from Greys Anatomy. Alex left Jo for his ex-wife Izzie Stevens, and Luddington is okay with that.

RELATED: Greys Anatomy Fans Have Strong Opinions On How Showrunners Are Dealing With Justin Chambers Mysterious Exit

She says that was the only way that Alex would leave Jo, and it really couldnt have happened any other way. Luddington says that in order for them to break up, it made sense. However, she admits it was really shocking.

Ultimately, Luddington wants what is best for her character. If that means a romance with Jackson, thats great. But, she believes that all Jo is looking for at the moment is comfort and friendship.

New episodes of Greys Anatomy air Thursday nights on ABC.

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'Grey's Anatomy': Why Camilla Luddington Originally Thought Her Role on the Show Was Not 'Meant to Be' - Showbiz Cheat Sheet

Ratings – Thursday’s Broadcast Ratings: ABC Tops Demo Race with "Grey’s Anatomy" – The Futon Critic

Primetime Preliminary Fast National Nielsen Data(includes all DVR playback through 3:00 am)

Here are the highlights of the 15 ad-sustained programs that aired in primetime on the broadcast networks last night (12/3/20):

[Note: Fast affiliate ratings are inaccurate for live sports.]

ABC (4.966 million viewers, #1; adults 18-49: 0.8, #1) pulled in front on Thursday thanks to its trio of "Station 19" (5.382 million viewers, #3; adults 18-49: 0.8, #T2), "Grey's Anatomy" (5.673 million viewers, #2; adults 18-49: 1.2, #1) and "A Million Little Things" (3.844 million viewers, #8; adults 18-49: 0.6, #T5).

CBS (4.171 million viewers, #2; adults 18-49: 0.5, #T2) was the number two draw with its lineup of "Young Sheldon" (7.270 million viewers, #1; adults 18-49: 0.8, #T2), "B Positive" (5.199 million viewers, #5; adults 18-49: 0.6, #T5), "Mom" (5.167 million viewers, #6; adults 18-49: 0.6, #T5), "The Unicorn" (3.617 million viewers, #9; adults 18-49: 0.5, #9) and "Star Trek: Discovery" (1.887 million viewers, #11; adults 18-49: 0.2, #T11).

Next up was NBC (4.070 million viewers, #3; adults 18-49: 0.5, #T2) and its mix of "The Voice Holiday Celebration" (5.270 million viewers, #4; adults 18-49: 0.7, #4), "Law & Order: Special Victims Unit" (4.036 million viewers, #7; adults 18-49: 0.6, #T5) and "Dateline NBC" (2.904 million viewers, #10; adults 18-49: 0.4, #10).

Meanwhile, FOX (0.840 million viewers, #4; adults 18-49: 0.2, #4) opted for coverage of the "MLS Playoffs 2020: Western Conference Semifinal" (0.840 million viewers, #12; adults 18-49: 0.2, #T11).

And finally, The CW (0.591 million viewers, #5; adults 18-49: 0.1, #5) closed out the night with "iHeartRadio Jingle Ball Greatest Moments" (0.526 million viewers, #15; adults 18-49: 0.1, #T13), a new "World's Funniest Animals" (0.615 million viewers, #14; adults 18-49: 0.1, #T13) and a repeat "World's Funniest Animals" (0.696 million viewers, #13; adults 18-49: 0.1, #T13).

Week-to-week changes (adults 18-49):+33.33% - Dateline NBC (vs. 11/19/20)+20.00% - Law & Order: Special Victims Unit (vs. 11/19/20)0.00% - Grey's Anatomy (vs. 11/19/20)0.00% - Young Sheldon (vs. 11/19/20)0.00% - B Positive (vs. 11/19/20)0.00% - Mom (vs. 11/19/20)0.00% - The Unicorn (vs. 11/19/20)0.00% - Star Trek: Discovery (vs. 11/19/20)0.00% - World's Funniest Animals (vs. 11/27/20)-11.11% - Station 19 (vs. 11/19/20)-14.29% - A Million Little Things (vs. 11/19/20)

Year-to-year changes (adults 18-49):+100.00% - Grey's Anatomy (vs. Same Time, Next Christmas)+16.67% - The Voice Holiday Celebration (vs. A Saturday Night Live Christmas Special (Repeat))0.00% - A Million Little Things (vs. Same Time, Next Christmas)0.00% - Law & Order: Special Victims Unit (vs. A Saturday Night Live Christmas Special (Repeat))0.00% - Dateline NBC (vs. Making It)-16.67% - The Unicorn (vs. Carol's Second Act)-20.00% - Station 19 (vs. A Charlie Brown Christmas (Repeat))-25.00% - B Positive (vs. The Unicorn)-25.00% - Mom-27.27% - Young Sheldon-60.00% - Star Trek: Discovery (vs. Evil)-66.67% - iHeartRadio Jingle Ball Greatest Moments (vs. Supernatural)-66.67% - World's Funniest Animals (vs. Legacies)-94.59% - MLS Playoffs 2020: Western Conference Semifinal (vs. Thursday Night Football)

Here are the highlights of the 13 ad-sustained programs that aired in primetime on the broadcast networks one year ago (12/5/19):

[Note: Fast affiliate ratings are inaccurate for live sports.]

FOX (13.638 million viewers, #1; adults 18-49: 3.7, #1) got another boost on Thursday with its presentations of "Thursday Night Football Pre-Game" (11.582 million viewers, #2; adults 18-49: 2.9, #2) and "Thursday Night Football" (14.049 million viewers, #1; adults 18-49: 3.9, #1).

ABC (4.124 million viewers, #3; adults 18-49: 0.8, #2) then was a distant second with its annual telecast of "A Charlie Brown Christmas" (4.954 million viewers, #6; adults 18-49: 1.0, #4) followed by the original movie "Same Time, Next Christmas" (3.709 million viewers, #8; adults 18-49: 0.6, #T7).

Next up was CBS (5.263 million viewers, #2; adults 18-49: 0.7, #3) and its mix of "Young Sheldon" (8.390 million viewers, #3; adults 18-49: 1.1, #3), "The Unicorn" (5.832 million viewers, #5; adults 18-49: 0.8, #T5), "Mom" (5.981 million viewers, #4; adults 18-49: 0.8, #T5), "Carol's Second Act" (4.685 million viewers, #7; adults 18-49: 0.6, #T7) and "Evil" (3.346 million viewers, #9; adults 18-49: 0.5, #10).

Meanwhile, NBC (2.651 million viewers, #4; adults 18-49: 0.5, #4) offered up "A Saturday Night Live Christmas Special" (3.125 million viewers, #10; adults 18-49: 0.6, #T7) and a new "Making It" (1.702 million viewers, #11; adults 18-49: 0.4, #11).

And finally, The CW (0.962 million viewers, #5; adults 18-49: 0.3, #5) rounded out the night with new episodes from "Supernatural" (1.066 million viewers, #12; adults 18-49: 0.3, #T12) and "Legacies" (0.857 million viewers, #13; adults 18-49: 0.3, #T12).

Week-to-week changes (adults 18-49):+50.00% - Supernatural (vs. 11/21/19)+50.00% - Legacies (vs. 11/21/19)+44.44% - Thursday Night Football (vs. 11/21/19)+31.82% - Thursday Night Football Pre-Game (vs. 11/21/19)+14.29% - The Unicorn (vs. 11/21/19)+10.00% - Young Sheldon (vs. 11/21/19)0.00% - Mom (vs. 11/21/19)0.00% - Carol's Second Act (vs. 11/21/19)0.00% - Evil (vs. 11/21/19)

Year-to-year changes (adults 18-49):+70.59% - Thursday Night Football Pre-Game+69.57% - Thursday Night Football0.00% - Making It (vs. Law & Order: Special Victims Unit (Repeat))-14.29% - Same Time, Next Christmas (vs. The Great American Baking Show: Holiday Edition)-25.00% - Legacies-25.00% - Carol's Second Act (vs. Murphy Brown)-28.57% - Evil (vs. SWAT)-33.33% - Mom-40.00% - Supernatural-47.62% - Young Sheldon (vs. The Big Bang Theory)-50.00% - The Unicorn (vs. Young Sheldon)

Source: Nielsen Media Research

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Ratings - Thursday's Broadcast Ratings: ABC Tops Demo Race with "Grey's Anatomy" - The Futon Critic

‘Grey’s Anatomy’: Will Jackson and Jo Become a Real Thing? Some Fans Are Already Calling Them Their Favorite New Couple – Showbiz Cheat Sheet

A new romance has started to emerge during the first few episodes of Greys Anatomy in season 17 and fans are already divided. In the premiere, Jo Karev (Camilla Luddington) asked Jackson Avery (Jesse Williams) for a sexual favor that didnt go as planned. But by episode 3, the odd couple had officially hooked up. While some fans are already calling Jo and Jackson their favorite couple, others dont want to watch Jackson get attached to another doctor at Grey Sloan Memorial.

When season 17 premiered, fans knew that the staff at Grey Sloan would be in the middle of the COVID pandemic. However, showrunner Krista Vernoff didnt tease any new romances. When Jo asked Jackson for a hookup in the premiere even though they had never so much as flirted, it was a big shock to fans.

No one saw this coming, and Greys Anatomy fans took to Twitter to share their opinions on the controversial pairing. Many pointed out that they are tired of seeing Jackson jumping from woman to woman. At the same time, others believe that Jo isnt over her husband, Alex Karev (Justin Chambers).

Last season, Alex unexpectedly left Jo for his ex-wife Izzie Stevens (Katherine Heigl) when Justin Chambers exited the series. This did not sit well with fans because it went against everything he believed in. That one decision destroyed 16 seasons of character development for Alex and sent Jo on a cringeworthy path that many fans are having a hard time watching.

Anyone else think that Jackson & Jo getting together is weird asf or just me?? #GreysAnatomy, one fan wrote. Another added, I dont like it. EW!! Jackson & Jo. EW! #GreysAnatomy. A third fan stated, This Jackson and Jo sh*t is pure Trash. #GreysAnatomy.

In an interview with Cosmopolitan, Luddington discussed her character moving on from her ex-husband while looking back on her controversial season 16 storyline. She says that she wants whats best for Jo but admits her breakup with Alex was shocking.

It did feel like probably the only way that [Alex] would leave her, I couldnt really imagine another way, Luddington explained. So in order for them to break up, it, to me, did make sense, even though it was really shocking.

RELATED: Greys Anatomy Fans Have Strong Opinions On How Showrunners Are Dealing With Justin Chambers Mysterious Exit

Luddington explained that Jo and Alex loved each other for a long time, and there was a lot of good that came out of that relationship. As Jo continues to work on herself and her mental health, Luddington believes fans will see her slowly but surely come out of this stronger.

Luddington says that season 17 will see Jo face a lot of new challenges. She says her character will have moments when she doesnt want to go to work because she finds it really difficult, stressful, and depressing. Through her struggles, Luddington believes Jo is looking for comfort and friendship.

Even though some Greys Anatomy fans are already calling Jo and Jackson their favorite couple, Luddington believes this relationship is more of a seed of friendship right now.

RELATED: Greys Anatomy Star Debbie Allen Claims Season 17 Couldnt Be More Relevant

I think that Jo shouldnt jump into anything serious right now, Luddington revealed. But I think if something organically happens, Im down. I obviously live and breathe this character and just want her to be happy. So if thats with Jackson Avery, its with Jackson Avery. If its with someone else, its with someone else.

Luddington is rooting for Jo to move on and find her true lover, her person. She also wants her character to have a family. The actress believes that is something her character is craving, and she loves that idea.

So I would like to see her happy with a partner, whoever that is and maybe some kids, Luddington said.

New episodes of Greys Anatomy air Thursday nights on ABC.

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'Grey's Anatomy': Will Jackson and Jo Become a Real Thing? Some Fans Are Already Calling Them Their Favorite New Couple - Showbiz Cheat Sheet

Cortez named interim chair in the Department of Biochemistry; York named Impossible Foods chief science officer – Vanderbilt University News

David Cortez, Richard N. ArmstrongChairforInnovation inBiochemistryandprofessor of biochemistry, has been named interimchairintheDepartment ofBiochemistrybeginningJan. 1.

This follows the departure of John York, who was recently named chief science officer of food technology startup Impossible Foods and will be moving to California.

The investments that Dr. York directed into the infrastructure, training and people in the Department of Biochemistry have been transformative. Simply put, I want to build on this momentum, Cortez said. I look forward to working with the faculty, staff and trainees to continue our shared pursuit of excellence in science discovery and education. The people in this department and at Vanderbilt make it special, and I will do everything I can to support them as they pursue their goals.

Cortez, also associate director for basic sciences research at theVanderbilt-Ingram Cancer Center, specializes in understanding the function of DNA damage response pathways in maintaining a healthy genome, and in understanding how those pathways are activated. His labs current projects include identifying new proteins involved in DNA damage response and developing cancer therapeutics that target that response. The trans-institutional Cortez lab is connected to theGenome Maintenance Research Programwithin the VICC,the Center in Molecular Toxicology,Vanderbilt Institute of Chemical Biologyand the Department of Biochemistry.

During Yorks tenure, the Department of Biochemistry became 2019s top NIH-funded department in the nation.

During Yorks tenure, the Department of Biochemistry became 2019s top NIH-funded department in the nation. With an expanded and diversified faculty, he invigorated the graduate and development research programs, building a shared sense of purpose and community in the department. These efforts fostered an environment that supports discovery science and curiosity-driven research, saidLawrence Marnett, dean of School of Medicine Basic Sciences.

My time at Vanderbilt has been a remarkable professional experience and a tremendous privilege. Together, we have built a discovery-science environment for recruitment of diverse faculty and trainees, York said. The commitment to academic excellence and pursuit of transformative solutions to problems facing the world shared by my colleagues and students is unparalleled, and the department is well-positioned to continue its steep upward trajectory. Iintend to maintain the One Vanderbilt spirit of collaboration in the next phase of my career and will remain a friend to all the wonderful colleagues I have worked with over the past nine years.

It has been an honor to work with John, who not only significantly increased funding for the Department of Biochemistry, but has also helped to establish Vanderbilt as a top destination for world-class faculty and scholars determined to make life-changing discoveries, said Provost and Vice Chancellor for Academic AffairsSusan R. Wente. I wish him luck with his next venture and am confident that David Cortez has the dedication and the visionary leadership to continue the remarkable momentum that John has established.

Cortez graduated summa cum laude from the University of Illinois at Champaign-Urbana with highest honors in biology and biochemistry and received his Ph.D. in molecular cancer biology from Duke University. After postdoctoral training as a Jane Coffin Childs Fellow with Stephen Elledge at the Baylor College of Medicine, he joined Vanderbilt in 2002. In 2009, Cortez was named professor of biochemistry and Ingram Professor of Cancer Research. His achievements have been recognized with the Howard Temin Award from the National Cancer Institute, the Wilson S. Stone Memorial Award from the MD Anderson Cancer Center and a Pew Scholar Award from the Pew Charitable Trusts. Cortez is a member of the editorial boards of the journalsCell ReportsandScience Advances, and in 2017 he was named a fellow of the American Association for the Advancement of Science.

While the departure of an esteemed colleague is never good news, we are proud of what John has built and wish him well in this exciting new endeavor. Our biochemistry students and faculty have benefitted tremendously from the hard work and dedication that John brought to his role, Marnett said. We are also extremely fortunate to have a world-class scientist like Dave Cortez assume the leadership of the department and continue its momentum. I look forward to working with him and anticipate he will be very successful.

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Cortez named interim chair in the Department of Biochemistry; York named Impossible Foods chief science officer - Vanderbilt University News

Impossible Foods Accelerates Innovation Strategy With New Hire – Progressive Grocer

Impossible Foods continues to accelerate its innovation strategy with its new hire of Vanderbilt University Biochemistry Department Chair Dr. John D. York, Ph.D., as chief science officer. The company plans to double the number of scientistson its team within a year as part of its plan to heavily invest in R&D.

The privately held food tech startup was founded in 2011 by Dr. Patrick O. Brown, M.D., Ph.D., professor emeritus of biochemistry at Stanford University, and a former Howard Hughes Medical Institute investigator, as a way to develop nutritious meat and dairy products from plants with a much smaller environmental footprint than meat from animals.

Impossible Foods scientists best-known achievement to date is the ImpossibleBurger. Impossible Foods first launched its plant-based Impossible Burger in retail stores in September 2019, and only a year later the product has expanded its reach to big retail names like Albertsons, The Kroger Co., Traders Joesand Walmart.

Under Yorks leadership, Impossible Foods will continue to build its food technology platform and expand basic research capabilities to accelerate next-generation plant-based products such as Impossible Pork, milk, steak and other foods.

Yorks first day at Redwood City, California-basedImpossible Foods will be Jan. 4. He will serve on Impossible Foods senior leadership team and oversee research and development, and product innovation. He will report directly to Brown, the company's CEO.

Throughout his career, John has contributed to discoveries in biochemistry thanks to his curiosity and risk tolerance, said Brown. Just as important, hes a proven and strong mentor and team leader. Im confident that John will make an immediate, positive contribution and quickly become an inspiring role model within our expanding R&D team.

York, a former Investigator for the Howard Hughes Medical Institute, has led the Department of Biochemistry at Vanderbilt University since 2012. His team paved the way for discoveries in protein structure and function, cell signaling and molecular genetics. The Midwest native received his undergraduate degree from the University of Iowa and his Ph.D. in molecular cell biology and biochemistry from Washington University, in Saint Louis.

The opportunity to use biochemistry to save the planet is a spectacular motivation, York said. That Impossible Foods is rooted in discovery science and engineering as a key innovation platform resonates with my core values and lifelong pursuits in research. Its an honor and privilege to be part of the team, and I look forward to the limitless future possibilities.

Impossible Foods intellectual property encompasses how to replicate the sensory experience of animal-derived meat, including how it tastes, cooks, sizzles and smells.

The company has raised approximately $1.5 billion since its founding in 2011, including $700 million in two rounds this year.The plant-based company said that it raised $200 million in its funding round in August led by New York-based new investor Coatue.

Other investors include Mirae Asset Global Investments, Khosla Ventures, Bill Gates, Google Ventures, Horizons Ventures, UBS, Viking Global Investors, Temasek, Sailing Capital and Open Philanthropy Project.

Further, Impossible Foods has been keeping busy during the pandemic, filling the needs of a growing plant-based category after retailers experienced meat shortages during the height ofpandemic stockpiling. It even entered the direct-to-consumer space with an e-commerce site,indicatingthat DTC is a natural fit for this pandemic worldas consumer behavior shifts.

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Impossible Foods Accelerates Innovation Strategy With New Hire - Progressive Grocer

LSU cancer researcher recognized, and other metro area health news – NOLA.com

LSU CANCER RESEARCH: TheAmerican Association for the Advancement of Science has honoredSuresh Alahari, of theLSU Health New Orleans School of Medicine, as a fellow, in recognition of hiscontributions in cancer research and teaching, with a focus on signal transduction. His research interests include the biochemistry of cell adhesion and the mechanism of action of Nischarin in tumor cell migration and invasion. Nischarin is a novel protein Alahari discovered that is involved in a number of biological processes, including the regulation of breast cancer cell migration and movement. He joined the LSU Health New Orleans faculty in 2004.

LSU HEALTH GRADUATE STUDIES: TheAssociation for Research in Vision and Ophthalmology has awarded its Emerging Advocate Award to Jarrod C. Harman, a student at LSU Health New Orleans School of Graduate Studies. The award recognizes ARVO members who have made efforts to integrate advocacy as part of their professional efforts early in their careers. Harman, who is pursuing a doctorate of philosophy degree in biochemistry and molecular biology, has been active in the Student Government Association at LSU Health New Orleans. He served as vice president and interim president. His advocacy work has included lobbying in Washington, D.C., for funding for the National Eye Institute and working with the Louisiana Lions Eye Foundation to perform vision screenings at inner-city primary schools.

OCHSNER BAPTIST: TheWomens Wellness and Survivorship Center at Ochsner Baptist will be the beneficiary of the New Me Time Challenge presented by the Crescent City Classic and Ochsner Health. The virtual challenge,focused on physical and mental health, is running through Jan. 14. The entry cost for either the 30-mile individual challenge or the 100-mile team challenge is $35. For every 5 miles logged, participants will unlock health-focused tips along with special access to wellness and nutrition offers provided by Ochsner Health. To register,visit http://www.ccc10k.com. For information, email customer.service@ccc10k.com.

SURVIVORS OF SUICIDE SUPPORT GROUP:NOLA Survivors of Suicide Loss is a free, peer-led support group for adults who have lost a loved one to suicide. The usual Zoom meeting time for the group is from 6:30 p.m. to 8 p.m. on the second and fourth Wednesdays of each month; to register to attend a meeting, visitnolasurvivors.com/contact-usor email survivors.nola@gmail.com.

UNIVERSITY OF HOLY CROSS:Free telecounseling is available from 11 a.m. to 8 p.m. Monday through Thursday from the University of Holy Cross. To schedule a session, call (504) 398-2168.

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LSU cancer researcher recognized, and other metro area health news - NOLA.com

Study finds Post Baccalaureate Program successful in diversifying physician workforce and helping underserved regions and populations – The South End

Medical schools willing to invest in qualified students from disadvantaged backgrounds can impact the nations physician workforce by increasing the number of doctors serving in regions designated as health professional shortage areas and medically underserved populations, according to a Wayne State University School of Medicine study published in Academic Medicine, the Journal of the Association of American Medical Colleges.

Impact of a 50-Year Premedical Postbaccalaureate Program in Graduating Physicians for Practice in Primary Care and Underserved Areas,a review of the impact of the School of Medicines Post Baccalaureate Program over its 50-year life, found that the program has been successful in graduating a large proportion of physicians from disadvantaged and diverse backgrounds. Many of these physicians went on to practice in regions with a shortage of doctors and in areas with underserved populations, accomplishing the goals of addressing the broad primary health care needs of all Americans, said lead author Herbert Smitherman Jr., M.D., M.P.H., professor of Internal Medicine and vice dean of Diversity and Community Affairs.

The study set out to evaluate the effectiveness of the School of Medicines premedical Post Baccalaureate Program in achieving its goals, measured by medical school, medical school graduation, primary care specialization and current practice.

The programs foundational goals are to provide academically-qualified students from lower socioeconomic, disadvantaged and underrepresented backgrounds the opportunity to become physicians; to identify and select students likely to return to their underserved communities to practice; to increase access to health care in underserved communities and therefore improve health outcomes; to increase the number of primary care physicians both locally and nationally; and to increase diversity in the physician workforce in an effort to address health inequities, disparities and social determinants of health.

To ensure that qualified minorities continued to have the opportunity to enter medical school, in 1969 the WSU School of Medicine established the Post Baccalaureate Program, the first of its kind in the nation. Initially launched to address the dearth of African American students entering medical schools, the free program immerses students into a year-long education in biochemistry, embryology, gross anatomy, histology and physiology. Many who graduated from the program were accepted into the WSU School of Medicine, but the program also served as a major pipeline for Black students into medical schools across the nation.

Five African American students were admitted into the initial program, which was so successful that in 1972 it expanded to accept 10 students. The first Post Baccalaureate Program student graduated from the Wayne State University School of Medicine in 1974. The program expanded its efforts to increase underrepresented minorities in medicine. Following the U.S. Supreme Courts 1978 Bakke decision, the program cast a wider net yet again, accepting socio-economically disadvantaged students regardless of race or ethnicity.

In the 1970s and early 1980s the program served as a major pipeline for the admission of African American students to medical schools across the country. During the 1980s and 1990s, the WSU School of Medicine earned the distinction of graduating more African American physicians than any other medical school in the nation, with the exception of Howard University in Washington, D.C., and Meharry Medical College in Nashville. Representatives of U.S. medical schools flocked to Detroit to learn how WSU accomplished the achievement.

Today, as many as 200 Michigan undergraduates apply for the program each year. A maximum of 16 students are accepted annually.

The study found that of 539 students who graduated from the program between 1979 and 2017:

463 (85.9%) successfully completed, then matriculated to the School of Medicine. Of those, 401 (86.6%) obtained a medical degree.Of the 401 who obtained a medical degree, 233 were female.The average investment per Post Baccalaureate Program student was approximately $52,000; for a M.D. graduate approximately $77,000. The majority of doctors who graduated the program (72.1%) lived in areas identified as medically underserved or having a shortage of physicians when they were admitted to the program. Today, 82% practice in such areas. Most practice primary care medicine.The programs total cost for 50 years was $32 million, an average investment of approximately $52,000 per student, and approximately $77,000 per graduated physician.

Today there are 250 similar programs in the United States, but a study by the AAMC found only 63 focused on underrepresented in medicine students and only 18 of those had explicit diversity-based missions. Because the WSU program cost structure is flexible, the study team reported, universities with existing medical education resources can readily adapt the program to meet their needs.

Other members of the study team include Anil Aranha, Ph.D., associate director of Diversity and Inclusion; DeAndrea Matthews, D.R.E., director of the Office of Diversity and Inclusion; Andrew Dignan, chief information officer and chief administrative officer for Health Centers Detroit Foundation Inc.; Mitchell Morrison, M.P.H., former intern in the Office of Diversity and Inclusion and now a clinical research associate for IQVIA/Roche & Genentech; Eric Ayers, M.D., associate professor of Medicine and Pediatrics; Leah Robinson, Ph.D., director of Academic Support for the Office of Diversity and Inclusion; Lynn Smitherman, M.D., associate professor of Pediatrics; Kevin Sprague, M.D., associate dean of Admissions; and Richard Baker, M.D., vice dean of Medical Education.

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Study finds Post Baccalaureate Program successful in diversifying physician workforce and helping underserved regions and populations - The South End

Fully Automatic Biochemistry Analyzer Market Size 2020 Global Analysis, Trends, Forecast up to 2027 – Cheshire Media

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What type of analysis short-term or long-term is added in the Fully Automatic Biochemistry Analyzer Market report?

This is important to sidestep any negative circumstances that may affect the development of the organizations. In addition, the associations need to comprehend Porters five powers that shape the market elements. In the event that the customers wish to add or eliminate the names of the organizations, it tends to be done, to suit the desires for the clients, for accomplishing long-haul objectives. SWOT investigation helps in uncovering the qualities and shortcomings of the business. The PESTLE investigation helps in checking the outer elements that shape the market overall. Subsequently, for making a name in the Fully Automatic Biochemistry Analyzer market, it gets important to get thought from both SWOT and PESTLE investigations.

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Fully Automatic Biochemistry Analyzer Market Size 2020 Global Analysis, Trends, Forecast up to 2027 - Cheshire Media

Dose-Response with Stereotactic Body Radiotherapy for Prostate Cancer: A Multi-Institutional Analysis of Pr… – UroToday

The use of stereotactic body radiation therapy (SBRT) for the definitive treatment of prostate cancer is increasing rapidly, yet the optimal dose(s) are still uncertain.13 Dose-escalation has been associated with improved biochemical and progression-free survival in conventionally fractionated external beam radiation therapy,4 but this has been minimally explored in SBRT.

The differential effect of SBRT dose on post-treatment prostate-specific antigen (PSA) kinetics has also not been directly evaluated. Various PSA nadir thresholds have been identified that may act as surrogates for early prediction of late outcomes with extended follow-up.5,6 These thresholds serve as critical tools in the interpretation and management of post-treatment PSA increases or fluctuations, as well as in the prognostication for when durable biochemical control appears likely. However, prior studies have also demonstrated that different radiation therapy modalities have differential degrees of prostate ablation and corresponding PSA decay kinetics, possibly related to the degree of dose deposition to the prostate gland.7,8 As more and more men are selecting SBRT for their care, understanding the SBRT dose-response for both PSA kinetics and biochemical control has become increasingly important.

In our study, we compared PSA kinetics and biochemical control among four commonly used prostate SBRT dose-fractionation regimens in a pooled multi-institutional analysis of 1,908 men with low-risk, intermediate-risk, and unfavorable intermediate-risk prostate cancer treated across eight institutions from 2003-2018. In order of increasing biologically equivalent dose, the regimens were: 35 Gy in 5 fractions (35/5), 36.25 Gy in 5 fractions (36.25/5), 40 Gy in 5 fractions (40/5), and 38 Gy in 4 fractions (38/4).

We observed that PSA decay kinetics followed a pattern consistent with dose-escalation, such that increasing biologically effective dose was significantly associated with a steeper slope of PSA decay, a lower PSA nadir (for 38/4 only), and a greater odds of achieving PSA threshold values of PSA 0.2 and 0.5 ng/mL. However, with respect to biochemical recurrence-free survival, 40/5 emerged as the winner compared to all other dose groups. Importantly, this finding emerged late, with no significant difference among the groups in the first five years, with 5-year biochemical recurrence-free survival rates ranging from 93-96.5%.

The finding that dose-escalation beyond the 40/5 dose level was not associated with gains in biochemical control presents the question of why 38/4, with higher biologically equivalent dose, would not provide at least comparable biochemical control. We posit that this may be due to slight imbalances in unfavorable risk patients, which though not statistically significant between groups may impact results beyond their actual clinical significance given that biochemical failures are relatively rare in the low- and intermediate-risk prostate cancer population.

Important questions that were not evaluated in our study still remain, including whether there are differences in acute or late toxicity between these regimens, and whether there are differences in patterns of disease recurrence particularly intra-prostatic versus extra-prostatic failures.

Our study is an important step in the process of solidifying the optimal prostate SBRT dose and the role of dose-escalation for localized, low- and intermediate-risk prostate cancer. However, the gold standard for evaluating this question will be a prospective trial, which we hope can be implemented in the future.

Written by: Rebecca G Levin-Epstein, Naomi Y Jiang, Xiaoyan Wang, Shrinivasa K Upadhyaya, Sean P Collins, Simeng Suy, Nima Aghdam, Constantine Mantz, Alan J Katz, Leszek Miszczyk, Aleksandra Napieralska, Agnieszka Namysl-Kaletka, Nicholas Prionas, Hilary Bagshaw, Mark K Buyyounouski, Minsong Cao, Nzhde Agazaryan, Audrey Dang, Ye Yuan, Patrick A Kupelian, Nicholas G Zaorsky, Daniel E Spratt, Osama Mohamad, Felix Y Feng, Brandon A Mahal, Paul C Boutros, Arun U Kishan, Jesus Juarez, David Shabsovich, Tommy Jiang, Sartajdeep Kahlon, Ankur Patel, Jay Patel, Nicholas G Nickols, Michael L Steinberg, Donald B Fuller, Amar U Kishan

Department of Radiation Oncology, University of California Los Angeles, Los Angeles, CA., UCLA Division of General Internal Medicine and Health Services Research., Department of Biological and Agricultural Engineering, University of California, Davis, Davis, California., Department of Radiation Medicine, Georgetown University Hospital., 21(st) Century Oncology, Inc., Fort Myers, FL., FROS Radiation Oncology and CyberKnife Center, Flushing, NY., Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Gliwice, Poland., Department of Radiation Oncology, Stanford University Medical Center., Department of Radiation Oncology, Tulane Medical Center, New Orleans, LA., Department of Radiation Oncology, Penn State Cancer Institute, Hershey, PA., Department of Radiation Oncology, University of Michigan, Ann Arbor, MI., Department of Radiation Oncology, University of California San Francisco, San Francisco, CA., Department of Radiation Oncology, University of Miami., Department of Human Genetics, University of California, Los Angeles, CA, USA; Department of Urology, University of California, Los Angeles, CA, USA., Department of Radiation Oncology, University of California Los Angeles, Los Angeles, CA; Department of Radiation Oncology, West Los Angeles Veterans Health Administration., Department of Radiation Oncology, Genesis Healthcare., Department of Radiation Oncology, University of California Los Angeles, Los Angeles, CA; Department of Urology, University of California, Los Angeles, CA, USA. Electronic address: .

References:

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Dose-Response with Stereotactic Body Radiotherapy for Prostate Cancer: A Multi-Institutional Analysis of Pr... - UroToday

Biochemistry Analyzer Market Incredible Possibilities, Growth Analysis and Forecast To 2028 ELITechGroup, EKF Diagnostics, Spinreact, Mindray – The…

Overview Of Biochemistry Analyzer Industry 2020-2028:

This has brought along several changes in This report also covers the impact of COVID-19 on the global market.

The Biochemistry Analyzer Market analysis summary by Reports Insights is a thorough study of the current trends leading to this vertical trend in various regions. Research summarizes important details related to market share, market size, applications, statistics and sales. In addition, this study emphasizes thorough competition analysis on market prospects, especially growth strategies that market experts claim.

Biochemistry Analyzer Market competition by top manufacturers as follow: URIT Medical Electronic, ELITechGroup, EKF Diagnostics, Spinreact, Mindray, Danaher, Roche Diagnostics

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The global Biochemistry Analyzer market has been segmented on the basis of technology, product type, application, distribution channel, end-user, and industry vertical, along with the geography, delivering valuable insights.

The Type Coverage in the Market are:

Semi-Automatic Biochemical Analyzers

Fully Automated Biochemistry Analyzers

Market Segment by Applications, covers:

Academic Research Institutes

Biotechnology Companies

Contract Research Organizations

Diagnostic Centres

Hospitals

Pharmaceutical Companies

Others

Market segment by Regions/Countries, this report coversNorth AmericaEuropeChinaRest of Asia PacificCentral & South AmericaMiddle East & Africa

Major factors covered in the report:

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The analysis objectives of the report are:

Our report offers:

Market share assessments for the regional and country level segments. Market share analysis of the top industry players. Strategic recommendations for the new entrants. Market forecasts for a minimum of 9 years of all the mentioned segments, sub segments and the regional markets. Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations). Strategic recommendations in key business segments based on the market estimations. Competitive landscaping mapping the key common trends. Company profiling with detailed strategies, financials, and recent developments. Supply chain trends mapping the latest technological advancements.

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Biochemistry Analyzer Market Incredible Possibilities, Growth Analysis and Forecast To 2028 ELITechGroup, EKF Diagnostics, Spinreact, Mindray - The...

Faze Medicines Launches With $81 Million Series A Financing to Leverage New Biology of Biomolecular Condensates to Treat Disease – Business Wire

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Faze Medicines, a biotechnology company pioneering therapeutics based on the groundbreaking new science of biomolecular condensates, today announced its launch and Series A financing of $81 million. Faze is founded by leading experts in the emerging field of biomolecular condensates with the mission of leveraging this fundamentally new understanding of cell biology to develop therapies to slow, halt or reverse disease pathology. The Series A was led by Third Rock Ventures with Novartis Venture Fund, Eli Lilly and Company, AbbVie Ventures, Invus, Catalio Capital Management, Casdin Capital and Alexandria Venture Investments participating.

Biomolecular condensates are membrane-less clusters of molecules, such as proteins and nucleic acids, that dynamically organize to perform a wide array of cell functions. Research over the past decade, including seminal work by Fazes founders, has found that disturbances in the behavior of condensates play a causative role in myriad human diseases, including amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Faze is now poised to deliver medical breakthroughs based on this fundamentally new understanding of cell biology.

The biology of condensates is the kind of science that will rewrite textbooks and, we believe, rewrite medicine, said Cary Pfeffer, M.D., interim chief executive officer of Faze and partner at Third Rock Ventures. Faze is founded by leading experts who have been integral to this field since its very beginnings. Their insights, coupled with the deep expertise of the team we have assembled, will enable us to realize the enormous potential of this new biology.

Cell biology is undergoing a transformation as we come to understand the integral role that biomolecular condensates play within cell processes from DNA repair to intracellular transport, added Rachel Meyers, Ph.D., chief scientific officer of Faze. Faze was founded to translate these exciting discoveries out of the lab and into the clinic, where they could make a real difference in treating diseases that have seen very little therapeutic progress.

The Series A will support Fazes preclinical research in two initial therapeutic focus areas ALS and myotonic dystrophy type 1 (DM1) as well as research to explore condensate biology in other disease areas. In ALS and DM1, a robust body of literature points to a causative role for condensate dysregulation. Leveraging state-of-the-art screening and proteomics techniques, Faze will identify proteins that are key components or regulators of disease-causing condensates, and then employ proprietary assays to discover small molecule drugs targeting these proteins.

Founders and Leadership

Faze is founded by renowned scientific leaders in the field of biomolecular condensates:

Fazes leadership team brings together accomplished biotechnology executives with decades of industry experience and deep scientific, drug discovery and drug development knowledge:

Joining Dr. Pfeffer on the companys inaugural board of directors is:

Faze has additionally established a robust group of expert advisors including those in the areas of drug discovery and clinical development.

About Faze Medicines

Faze Medicines is a biotechnology company harnessing the groundbreaking new science of biomolecular condensates to create medical breakthroughs. Faze was founded by renowned scientific leaders in the field of biomolecular condensates and is supported by a world-class syndicate of investors including Third Rock Ventures, Novartis Venture Fund, Eli Lilly and Company, AbbVie Ventures, Invus, Catalio Capital Management, Casdin Capital and Alexandria Venture Investments. For more information, visit fazemed.com.

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Faze Medicines Launches With $81 Million Series A Financing to Leverage New Biology of Biomolecular Condensates to Treat Disease - Business Wire

Heparin Market to Hit USD 11.43 Billion with a CAGR of 3.9% by 2027; Rising Prevalence of Chronic Diseases to Propel Business, states Fortune Business…

Pune, India, Dec. 10, 2020 (GLOBE NEWSWIRE) -- The global heparin market size is expected to reach USD 11.43 billion by 2027, exhibiting a CAGR of 3.9% during the forecast period. The market size stood at USD 8.39 billion in 2019. The increasing cases of cardiovascular diseases such as deep vein thrombosis & pulmonary embolism are expected to spur demand for heparin in the forthcoming years, states Fortune Business Insights, in a report. The market size in North America stood at USD 4.28 billion in 2019. The growth in the region is attributed to the prevalence of cardiovascular diseases such as pulmonary embolism. The higher adoption of advanced heparin products will have an excellent effect on the market in the region.

Key Development:

May 2019: Pfizer, Inc. announced that it has received the approval from the U.S. FDA for the administration of its heparin product offering, Fragmin to minimize the recurrence of symptomatic venous thromboembolism (VTE) in pediatric patients aged one month and above.

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Rising Incidence of Chronic Disorders to Incite Business Development

The increasing prevalence of cardiovascular diseases around the world, including heart attacks and strokes will spur opportunities for the market. As per the American Heart Association (AHA) Heart Disease and Stroke Statistics, an estimated 5.3 million Americans suffered from atrial fibrillation in 2019.

The growing demand for heparin among patients can have an excellent impact on the market. As per the Centers for Disease Control and Prevention, coronary heart disease is the most common type of heart disease, killing 365,914 people in 2017.4. About18.2 million adultsage 20 and older have CAD (about 6.7%). Moreover, 2 in 10 deaths from CAD happen in adults less than 65 years old. The increasing awareness about the benefits of heparin in the treatment and management of heart diseases will improve the prospects of the market in the foreseeable future.

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Minimal Impact on the Market During COVID-19

The limitations on non-essential medical procedures and consultations has had a drastic impact on the global market amid COVID-19. The healthcare industry has observed a decline in other medical services besides coronavirus. The increased emphasis on COVIDs vaccine has reduced the demand for other therapeutics.

Furthermore, the lack of supply and production of heparin will simultaneously limit the scope of the market. However, government initiatives, including heavy investments and free medical aid will influence the healthy growth of the market in the time of the pandemic.

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High Adoption of Advanced Products to Boost Market in North America

The market size in North America stood at USD 4.28 billion in 2019. The growth in the region is attributed to the prevalence of cardiovascular diseases such as pulmonary embolism. The higher adoption of advanced heparin products will have an excellent effect on the market in the region.

The increasing healthcare expenditure is expected to foster the healthy growth of the market in North America. The presence of major companies can further enhance the development of the market in the region. Europe is expected to hold the largest share owing to the acceptance of technologically advanced products in the region. The rising number of patients suffering from a range of cardiovascular diseases will further spur opportunities in the region.

Asia Pacific is expected to experience a rapid growth rate owing to the growing patient population. The surging healthcare expenditure in the developing nations will have a tremendous effect on the market in Asia Pacific.

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Heparin Market to Hit USD 11.43 Billion with a CAGR of 3.9% by 2027; Rising Prevalence of Chronic Diseases to Propel Business, states Fortune Business...

Automated Biochemistry Analyzers Industry Research Report, Growth Trends and Competitive Analysis 2020-2027: Abbott, Danaher, Hitachi, Roche, Siemens,…

This report studies theAutomated Biochemistry Analyzersmarketwith many aspects of the industry like the market size, market status, market trends and forecast, the report also provides brief information of the competitors and the specific growth opportunities with key market drivers. Find the complete Automated Biochemistry Analyzers market analysis segmented by companies, region, type and applications in the report.

New vendors in the market are facing tough competition from established international vendors as they struggle with technological innovations, reliability and quality issues. The report will answer questions about the current market developments and the scope of competition, opportunity cost and more.

The major players covered in Automated Biochemistry Analyzers Markets: Abbott, Danaher, Hitachi, Roche, Siemens, Thermo Fisher Scientific, and more

The final report will add the analysis of the Impact of Covid-19 in this report Automated Biochemistry Analyzers industry.

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Automated Biochemistry AnalyzersMarket continues to evolve and expand in terms of the number of companies, products, and applications that illustrates the growth perspectives. The report also covers the list of Product range and Applications with SWOT analysis, CAGR value, further adding the essential business analytics. Automated Biochemistry Analyzers Market research analysis identifies the latest trends and primary factors responsible for market growth enabling the Organizations to flourish with much exposure to the markets.

This report focuses on the globalAutomated Biochemistry Analyzersstatus, future forecast, growth opportunity, key market and key players. The study objectives are to present the Automated Biochemistry Analyzers development inUnited States, Europe, China, Japan, Southeast Asia, India, and Central & South America.

Market segment by Type, the product can be split into

Market segment by Application, split into

Research Objectives:

TheAutomated Biochemistry Analyzersmarket research report completely covers the vital statistics of the capacity, production, value, cost/profit, supply/demand import/export, further divided by company and country, and by application/type for best possible updated data representation in the figures, tables, pie chart, and graphs. These data representations provide predictive data regarding the future estimations for convincing market growth. The detailed and comprehensive knowledge about our publishers makes us out of the box in case of market analysis.

Key questions answered in the report include:

Table of Contents

Chapter 1:GlobalAutomated Biochemistry AnalyzersMarket Overview

Chapter 2:Automated Biochemistry Analyzers Market Data Analysis

Chapter 3:Automated Biochemistry Analyzers Technical Data Analysis

Chapter 4:Automated Biochemistry Analyzers Government Policy and News

Chapter 5:Global Automated Biochemistry Analyzers Market Manufacturing Process and Cost Structure

Chapter 6:Automated Biochemistry Analyzers Productions Supply Sales Demand Market Status and Forecast

Chapter 7:Automated Biochemistry Analyzers Key Manufacturers

Chapter 8:Up and Down Stream Industry Analysis

Chapter 9:Marketing Strategy -Automated Biochemistry Analyzers Analysis

Chapter 10:Automated Biochemistry Analyzers Development Trend Analysis

Chapter 11:Global Automated Biochemistry Analyzers Market New Project Investment Feasibility Analysis

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Reports and Marketsis not just another company in this domain but is a part of a veteran group calledAlgoro Research Consultants Pvt. Ltd. It offers premium progressive statistical surveying, market research reports, analysis & forecast data for a wide range of sectors both for the government and private agencies all across the world. The database of the company is updated on a daily basis. Our database contains a variety of industry verticals that include: Food Beverage, Automotive, Chemicals and Energy, IT & Telecom, Consumer, Healthcare, and many more. Each and every report goes through the appropriate research methodology, Checked from the professionals and analysts.

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Automated Biochemistry Analyzers Industry Research Report, Growth Trends and Competitive Analysis 2020-2027: Abbott, Danaher, Hitachi, Roche, Siemens,...

Synedgen Partnership with the University of New South Wales Receives Australian Research Council (ARC) Grant – Business Wire

CLAREMONT, Calif.--(BUSINESS WIRE)--Synedgen, a biotechnology company using glycopolymer chemistry to develop drugs that enhance and control signaling in the innate immune system, today announced that UNSW in partnership with Synedgen has been awarded an A$600,633, 3-year, research grant from the Australian Research Council (ARC) to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx. The resulting study will be the first to explore how charged glycopolymers interact with the endothelial glycocalyx with the goal of mapping the lifecycle of the network of membrane-bound proteoglycans and glycoprotein.

Synedgen is developing molecules that interact with the glycocalyx to control the movement of cells and molecules across the endothelium and we are keen to deepen the understanding of the dynamic structure of and implicit role of the endothelial glycocalyx in innate immune signaling. This ARC-funded project aims to address this knowledge deficit by mechanistically elucidating and describing the dynamic lifecycle of the endothelial glycocalyx, said Shenda Baker, Ph.D., President and Chief Executive Officer of Synedgen. We are grateful to the ARC for this grant and honored to be working with Drs. Megan Lord and John Whitelock of the University of New South Wales, experts in proteoglycan interactions and signaling. We anticipate that results of these efforts can be leveraged to inform the development of targeted molecules to treat diseases involving the endothelial glycocalyx including cardiovascular and pulmonary diseases, stroke and traumatic brain injury.

We still have much to learn about the structure and dynamics of the endothelial glycocalyx, a network of proteoglycans and glycosaminoglycans anchored at the cell surface, said Megan Lord, Ph.D., lead PI on the grant. Synedgens glycopolymers will enable us to study interactions at the endothelial interface and develop new ways to support endothelial functions.

Synedgen believes the findings of the ARC-sponsored project will inform the companys future research and development activities over the next 3-7 years.

Synedgens CEO, Shenda Baker, gave a related keynote lecture at the Pan Pacific Connective Tissue Societies Symposium on November 25, 2020, titled, Glycopolymer interactions with the glycocalyx to modulate innate immune responses after dermal injury. The 12th Pan Pacific Connective Tissue Societies Symposium, a virtual event held in November 2020, was held in conjunction with the scientific meetings of the Australian Wound & Tissue Repair Society (AWTRS) and Matrix Biology Society of Australia and New Zealand (MBSANZ).

About Synedgen

Synedgen is a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system. The companys lead development candidate is SYGN305 for gastrointestinal mucositis, where a large unmet need exists to prevent intestinal radiation injury, the single most important dose-limiting factor in cancer radiotherapy. Synedgens glycopolymer platform has already generated five FDA 510(k)-cleared therapeutics, one OTC drug, one veterinary indexed drug, and an out-licensed Phase 2 program, to Synspira, for the potential treatment of pulmonary complications of cystic fibrosis. Synedgen has research and manufacturing facilities in Claremont, California. For more information please visit http://www.synedgen.com.

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Synedgen Partnership with the University of New South Wales Receives Australian Research Council (ARC) Grant - Business Wire

Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L – Science…

The main protease (Mpro) of SARS-CoV-2 is a key antiviral drug target. While most Mpro inhibitors have a -lactam glutamine surrogate at the P1 position, we recently found that several Mpro inhibitors have hydrophobic moieties at the P1 site, including calpain inhibitors II and XII, which are also active against human cathepsin L, a host protease that is important for viral entry. In this study, we solved x-ray crystal structures of Mpro in complex with calpain inhibitors II and XII and three analogs of GC-376. The structure of Mpro with calpain inhibitor II confirmed that the S1 pocket can accommodate a hydrophobic methionine side chain, challenging the idea that a hydrophilic residue is necessary at this position. The structure of calpain inhibitor XII revealed an unexpected, inverted binding pose. Together, the biochemical, computational, structural, and cellular data presented herein provide new directions for the development of dual inhibitors as SARS-CoV-2 antivirals.

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Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L - Science...

Here’s why there’s *no* chance of a liberal takeover of Washington – CNN

"We know the direction the country would take, and we're going to continue to make sure that Georgians understand that our very way of life here in Georgia and across the country is under attack by the left," said Sen. Kelly Loeffler (R) during Sunday night's candidate debate. (She also said that her opponent, Democrat Raphael Warnock, would bring in "socialism" on eight separate occasions in the debate.)

It's all part of the broader Republican messaging effort to suggest that if Democrats retake control of the Senate, that they will somehow name Rep. Alexandria Ocasio Cortez (D-New York) president and begin the dismantling of capitalism. Or something.

What that rhetoric misses is this: West Virginia Sen. Joe Manchin (D).

Manchin is, unapologetically, the most conservative Democrat in the Senate caucus. And he's on the record as:

Which, well, virtually ensures that the picture Senate Republicans are trying to paint of a Democratic Senate majority will never come to pass.

Because, at best, Democrats will have 50 seats -- come January 6. Which means that if Manchin sides with Republicans on ANY vote, Democrats lose that vote. Heck, even a tweet or an off-hand statement expressing disapproval for a Democratic agenda item from Manchin could force his party to recalibrate its legislative strategy.

Which makes Manchin a very, very powerful figure in Washington over the next few years -- especially if his party winds up sweeping both seats in Georgia next month.

And makes it impossible to realistically imagine that any sort of progressive dream will be coming true no matter the outcome in the Peach State.

The Point: Watch what Manchin says and does between now and January 20, 2021. His voice could well be the most important one in the Senate when the next Congress convenes.

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Here's why there's *no* chance of a liberal takeover of Washington - CNN

LETTER – The Liberal Democrats are an alternative – Daily Echo

I thank, Gerald Ingram, for his polite response to my own letter.

Where, I still claimed that readers ought to be more supportive of the Liberal Democrats, as they believe in having a United Kingdom.

Plus we should have stayed full members of the EU.

Where, we were the second strongest economy and third largest member within the 28.

Gerald suggests the Lib/Dems should join the Labour Party as a left wing opposition.

I, for one, would never support the Labour Party.

I would never vote Conservative.

That is why I still claim the Liberal Democrats are an alternative.

Politics is changing.

Your Prime Minster has now grabbed the Green Party policies over climate change looking for new energy sources.

Something he would have written off as nonsense.

Rather as he did with the coronavirus.

Plus, of course, our membership of the European Union which the Conservatives were very much in favour of. Indeed, built on.

It was the Labour Party, who were are not in favour.

Feels like Trump's America.

Richard Grant

Burley

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LETTER - The Liberal Democrats are an alternative - Daily Echo

Conservatism and Liberalism: Two Books on the Great Divide – The Wall Street Journal

Every man and every woman, it seems, knows Gilbert and Sullivans quipping lines from Iolanthe (1882): That every boy and every gal / Thats born into the world alive. / Is either a little Liberal / Or else a little Conservative. When the lines were first sung, the labels matched up with Britains political parties, but they obviously have a wider applicationeach calling to mind, then and now, a cultural outlook, an inclination, a temperament, even a philosophy. Over time, of course, even the firmest definition will shift, making easy summary difficult and historical circumstancecontext, that iscrucial to our understanding of what liberalism is and how conservatism differs from it. These days, we may also ask: What sets the two sides of democratic politics so far apart?

Edmund Fawcett, a former editor and correspondent at the Economist, grappled with one end of this polarity in Liberalism: The Life of an Idea, published in 2014 and revised four years later. He now explores its opposing force in Conservatism: The Fight for a Tradition. A self-described left-wing liberal, Mr. Fawcett believes that both categories of thought (and politics) are facing critical tests, making it all the more urgent that we grasp their genealogyhow they developed and what they have come to represent. He calls his explorations historical essays, and indeed they are written in a reflective mode, though at times in an impassioned style. Members of both thought-categories will find much to learn from both books, not least from the historical figures Mr. Fawcett brings into view.

Mr. Fawcett notes that, in the broadest terms, the modern era in advanced societies has been governed by a liberal outlook, one in which the liberty or freedom of the individual has been increasingly protected from the state or liberated from custom, hierarchy and the institutionsnotably, the churchthat once dictated social relations and guided mans understanding of himself. The origins of this outlook, he notes, can be traced to the Enlightenment, when reason was elevated to an exalted position and, it was believed, a rational scrutiny of both principles and institutions would lead humanity away from dark superstition and upward toward the light.

Enlightenment thinkers, Mr. Fawcett reminds us, encouraged the idea that society might be understood and thereby changed for the better. They also sought to sever moral codes from their traditional mooring, or at least to rethink them: As Mr. Fawcett puts it, David Hume and Immanuel Kant welcomed liberty from ethical tutelage so that men could determine their own standards of conduct. The German statesman Wilhelm von Humboldt saw education as a way to realize individual possibility rather than, as tradition would have it, train for an occupation or a social role. Benjamin Constant, in France, focused on the concept of liberty, which he defined as a condition of existence allowing people to turn away interference from either society or the state. Calling absolute power radically illegitimate, Franois Guizot insisted that human imperfection meant that no person, class, faith or interest should have the final say. Like other French liberals of his day, he sought a juste milieua place where interests and ideas could be balanced. Enlightenment philosophers on the Continent also challenged the assumptions of the ancien rgime, helping open careers to talent and remove restrictions on office-holding long governed by religion and class.

These currents of thought we associate with the 18th century, and for good reason, but after the shock of the American and French revolutions, they were dammed up by the Napoleonic Wars and an interlude of restoration. It was only in the 1830s that the dam broke. A period of rapid changebrought on by the dislocations of the Industrial Revolution, the railways remarkable shrinking of distance, and episodes of agricultural depression and financial crisisdemanded a re-assessment of established patterns of thought and governance. Enlightenment-driven liberalism was one mode of response; conservatism, one might say, was a response to the response.

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Conservatism and Liberalism: Two Books on the Great Divide - The Wall Street Journal

White clicktivism: why are some Americans woke online but not in real life? – The Guardian

In the winter of 2018, Gwen Kansen, a 33-year-old self-professed liberal, met a man called Elias in a bar. Within minutes, she knew he was intense. His phone screensaver was of Pepe the Frog a symbol of the alt-right movement. His style reminded her of a Confederate soldier, and he wore badges proudly proclaiming his hatred for political correctness.

It was not long before he disclosed he was a member of the Proud Boys, a far-right, male-only political organization. Still, Kansen didnt put an end to the date. They drank rum and cokes; spoke about music, books and exes; and that night, he walked her home. The two had a brief fling. Later, Kansen wrote an article about coming to terms with her so-called liberal beliefs while still choosing to entertain the affair.

The article was met with backlash. People spammed her Twitter, questioning her morals, dating standards and self awareness. How could a so-called liberal woman choose to date a member of a group known for its anti-Muslim and misogynistic rhetoric, associations with extremist gatherings, and a white nationalist agenda? The consequences of this group are real-life harm: death threats, racial slurs, violence and even murder, and yet Kansen saw it as an opportunity to dabble in a forbidden experience.

The story might sound extreme, especially following a summer of listening and learning. Following the deaths of George Floyd, Ahmaud Arbery, and Breonna Taylor, many white Americans have spent the past year taking part in a social justice movement online and on the ground, combating systemic racism and opposing police brutality. Bookstores sold out of race education books, social media timelines were consumed with Black Lives Matter support, and protests drew diverse crowds.

But then we saw the election results. Trump won the support of 74 million Americans this year including 55% of white women and 61% of white men. Even in liberal hotbeds like New York, California and Washington, Trump maintained 48%, 47%, and 36% of the white vote.

Given continued white support for a man who has refused to denounce white supremacy, lied about the severity of the coronavirus, and hasnt been shy about his sexist and misogynistic beliefs, can liberal white Americans really be doing the groundwork their social media profiles would have you believe?

I thought maybe the [Proud Boys] were four steps away from the Nazis, Kansen said by phone one Monday evening. I now realize maybe theyre one or two.

When speaking with Kansen, I was curious to know her definition of liberal. Im a Democrat. Ill be friends with anyone, like anyone from different sides of the political spectrum. I guess that makes me liberal, she said. Liberals are more open to experiences.

Maybe they are. But a woman of color would be physically threatened if their date exposed their Proud Boy membership over a few drinks. Kansen, a white woman, did not feel at risk and so it was partly her privilege not her tolerance that gave her a hall pass to entertain a member of a white supremacist group.

Although she compares them to the Nazi party, she still felt a relationship with a Proud Boy was fair game. If youre saying that Im more interested in myself than I am in having integrity towards a cause then yeah, youre right, she said. Kansens date isnt one most would consider progressive, but she liked him, and so what she saw as her liberal duties slid. Kansens ability to set aside the mans differences extreme ones that contribute to a systemic problem liberals claim to want to dismantle is not so uncommon, especially among family members and longtime friends: 35% of Biden voters in 2020 reported they have a few close friends who supported Trump.

Does this simply come down to being more accepting of others political views? A superior mastery of compartmentalization? Or does it stem from a place of selfishness, as ultimately it is not their wellbeing that will suffer?

And what should it leave us to believe about the inner workings, impact and true beliefs of self-professed liberals who behave in ways that dont align with those beliefs?

Amanda Booth first witnessed the phenomenon of labeling yourself progressive online while endorsing different values in real life when her white co-workers mentioned buying property in East Austin. The area is popularly known as a redlined neighborhood, primarily housing Austins Black and brown community. Recently, the East Side has undergone major renovations with new modern houses, trendy bars, and local coffee shops, as gentrification pushes out the original inhabitants of the area.

But when Booth, a 24-year old content designer in Austin, confronted her co-workers by explaining that Black and Hispanic people were being displaced from the area, her remarks were met with silence. Both of these guys proudly express themselves as being more on the progressive side of the Democratic party, Booth said. Mind you, both of them have houses on the East Side now.

Its not enough to believe in racial justice and that Black people deserve things. White people need to begin giving up their privilege. The least they can do is try to plug into Austins anti-displacement efforts. But I dont really see those people doing that, Booth continued.

Online, her co-workers share a lot of anti-racist rhetoric. They share videos by Black activists and quotes like Its not enough to be not racist. You have to be anti-racist. But Booth thinks people are watering anti-racism down if they are putting in very little practical effort to match their online beliefs.

There is this cognitive dissonance where they are like, Oh yeah, our city is so segregated. Our systems are built on racism and anti-Black sentiment. But then they dont give up anything, she says. They feel like realizing it, or accepting their privilege, is enough.

Very high-profile examples of police shootings coupled with the breathtaking rise in incarceration, maternal and infant mortality, and coronavirus deaths in the Black community have inspired a great awakening for people especially white people seeing it for the first time. But what if this has led to a shift in posturing, without a real shift in accountability?

People intellectually understand white privilege and can see it, but also like how it makes their life easier, explains Shannon Cavanagh, an associate professor in the department of sociology and a faculty research associate at the Population Research Center at the University of Texas at Austin. Those guys who buy in East Austin because its cool and hip and cheaper than living on West 6th Street might be displacing a faceless Black family but there is a Whole Foods now and a cool bar scene, she says, adding: They wanna do the right thing but its hard financially mostly and the status quo actually works for them.

The fake indicator of progress of acknowledging privilege publicly while working against it privately has tricked many white liberals into thinking they are actively bettering conditions for people of color. Social media holds an immense influence in this way of thinking. Its simple to tweet that youre doing the work, add #BLM to your bio, attend a protest and donate to a bail fund not without posting photos and screengrabs, of course but once it comes down to the real, hard work, the momentum stops. Oftentimes, our social media presence reflects how we want to be perceived, rather than our authentic selves, or our real day-to-day experience. Being woke is on trend at the moment, and everyone is tapping in, virtually at least.

The issues that helped awaken folks to systemic racism police killings, mass incarceration, Covid deaths are fundamentally structural and require a structural response, Cavanagh explains. Racism is baked into our medical system, educational system, housing, employment sure, white people need to do more individually but our institutions are the things that really need to change.

Despite racism being a structural problem, individual actions still matter. But, Cavanagh warns, people may believe in equality while opting out of decisions that are hard for them personally. Voting can be thought of as a relatively low-cost act of solidarity and commitment to justice, unlike cutting off ties to your racist mother, she says.

The events of the last decade or so much of it illuminated and amplified by social media have made white people confront systemic racism in a new way. Or it might all be performative social media is a performance and being racially woke is a new flavor.

Whether it be cutting off relationships with people who vote to uphold white nationalist beliefs (after trying to educate them, of course) or opting for a neighborhood that wont place you as a gentrifier, there are several ways that white liberals can practice what they post. By giving up privilege, higher salaries, houses in gentrified parts of Texas, and other situations that convenience them, white liberals could prove that theyre actually doing the work, beyond lip service and black squares. Maybe thats why white people keep voting for Trump they are invested, financially but also psychologically, in keeping the society tipped in our favor, Cavanagh says.

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White clicktivism: why are some Americans woke online but not in real life? - The Guardian

The Liberal Arts Institution and the Scaled Online Learning Platform Provider | Learning Innovation – Inside Higher Ed

Say that the leadership from a liberal arts institution of higher learning and a scaled online learning platform provider should get together to discuss a potential partnership.

What might they talk about?

Here, I'm taking an expansive view of liberal arts institutions, one that covers all residential colleges and universities that require students to progress through a broad liberal curriculum to graduate. The scaled online learning platform providers that I have in mind include Coursera and edX. FutureLearn, Udacity, Udemy, Canvas Network and others are also sometimes mentioned as online learning platforms designed to serve students at scale.

I propose an agenda covering five topics, three of which are opportunities and two of which are challenges.

Opportunity No. 1: Advancing Liberal Arts Learning

Any partnership between a liberal arts school and a scaled online learning platform providers must -- ultimately -- be built around a commitment to strengthen the liberal arts model of higher education. These partnerships cannot (solely) be about the development of new revenues. Instead, the goal of these partnerships should be to leverage experimentation in online education at scale to advance "traditional" teaching and learning.

It will be difficult for individual colleges and universities to accomplish this goal on their own. Fortunately, partnering with Coursera and/or edX is not only about getting access to an online learning platform designed to operate at scale. Partnership with edX and Coursera comes with access to a community of practice. EdX lists 60 charter member colleges and universities, and many more additional nonprofit institutions, on its site. Coursera lists 225 partners, with over 50 university partners in the U.S. alone.

Any discussion of a partnership between a school and edX or Coursera should start, I think, with how these networks of institutions are learning together to advance liberal arts learning. There is a conversation to be had about the relationship between online courses aimed at hundreds (or thousands or tens of thousands) and the intimate and relational-based mode of teaching and learning that is a hallmark of the residential, educational experience. These two modes of instruction, one intimate and one at scale, should not be viewed in opposition. There are ways in which each can advance the other by lowering costs and improving quality. The conversation to be had is how to bring these two methods of teaching and learning into alignment.

Opportunity No. 2: Noncredit and Nondegree Programs

The fastest-growing segment of the postsecondary market is noncredit-bearing and nondegree-granting online certificates and other programs. The question is, will these programs be limited to skills-based certificates, or is there room in this market for a more liberal arts-based approach?

On the one hand, we know that there is an enormous global demand for lifelong learning. The first part of the MOOC experiment, post-2012 until 2020, proved that learners would participate in free (or very low cost) open online educational offerings. However, what we learned from the first phase of MOOCs is that free open online learning is not financially sustainable (at least on its own) in the long run. There needs to be a balance of nondegree/noncredit online courses that learners will pay for schools to continue investing in online learning at scale.

Learners will pay for skills-based online certificates in topics such as data science, programming, machine learning, etc. Can noncredit and nondegree online programs move up the value chain to encompass rigorous educational opportunities in areas such as critical thinking, analytical and quantitative skill development, communication, and leadership? The value of a liberal arts education is that it trains students to not only get that first job after graduation but to adapt and evolve to a lifetime of productive work and contribution. A liberal arts education teaches one how to think and to continually learn, skills that will become increasingly important in an age of smart robots and global competition.

The conversation here between leaders of liberal arts schools and leaders of scaled online learning platform providers is about the opportunity for a distinctively liberal arts approach to noncredit and nondegree programs.

Opportunity No. 3: Funnels and Pathways Into Degrees

We are in the middle of a shift in the traditional admissions funnel. I'm mostly thinking of master's programs, although I could see how this change will eventually move to the undergraduate level. This is a shift from a funnel built on advertising and marketing to one built on learning. In the past, colleges and universities were forced to spend ever-increasing dollars on digital marketing and advertising (think Google keywords). The future belongs to the integration between noncredit online programs and credit-bearing (residential and online) degrees.

Within the next few years (I expect this change to come fast), applicants to master's programs will no longer be screened by test scores or transcripts. Instead, qualified applicants will be discovered (and admitted) based on their noncredit online programs' performance. When accepted, these newly enrolled students will receive credit for completing the online certificates, lower their overall tuition cost and decrease the time to graduation. Schools will benefit by getting a better prepared and more diverse set of learners, as noncredit online programs are both globally accessible and better predictors of subsequent performance than test scores or prior grades. (At least I believe this will prove to be true -- but there is research to be done.)

The conversation here is about how noncredit and degree programs are not substitutes but complements. This is a concrete example of how scaled online learning and intimate residential learning can work together to benefit both learners and schools.

While there is much to discuss around these three opportunities, there are also significant challenges to any relationship between a liberal arts school and a scaled online platform provider. Here are two that we might discuss:

Challenge No. 1: Online Degrees at Scale

Coursera and edX are moving quickly -- and successfully -- into degrees. This is an exciting development, as online degrees at scale can bend the educational cost curve. There are real questions and concerns on liberal arts campuses, however, about how to bring intimacy and rigor to any scaled online degree program.

Liberal arts institutions know how to offer high-quality degree programs. We have been doing this for many years. The challenge is how to provide degree programs that are affordable to students while also being financially sustainable for institutions. That is a hard problem and getting more difficult each day. Leveraging digital platforms to scale online degree programs may be one solution for driving down costs while maintaining quality. Creating these programs to build on the core strengths of a relational-based educational philosophy, one defined by rigor and intimacy, will be exceedingly difficult.

Liberal arts institutions would love to make online degree programs more affordable and accessible while also bringing in the tuition dollars necessary for long-term financial sustainability. Getting to this goal will hard. We should discuss how to go forward.

Challenge No. 2: The Long Game

The second challenge that leaders of liberal arts institutions and leaders of scaled online learning platforms might want to discuss is the long game. Today, edX has over 34 million learners on its platform, and Coursera has over 76 million learners. What edX and Coursera do is not only provide a platform in which online learning can scale, they also aggregate a user base of global learners.

Should liberal arts colleges and universities depend on platform providers such as edX and Coursera to reach the global learner population? What is the risk to schools of being tied into these partner ecosystems instead of going their own ways to build their own branded college and university platforms and global educational brands? Do schools that invest in partnerships with edX and Coursera risk commodification of their educational offerings? How do colleges and universities differentiate their institutional brands when they are among many institutions on a platform?

These are difficult discussions about long-term strategy. These questions do not argue against partnering with platforms such as edX and Coursera. I'd argue that the best way to answer these questions is to experiment and partner -- but to do so with eyes and ears wide-open.

The conversation that liberal arts schools have with scaled online learning platform providers should be around the colleges and universities' concerns and goals. The liberal arts are about asking questions, thinking critically and discovering how to be an active participant in shaping one's future.

Partnering with platforms such as edX and Coursera will be one way to create the liberal arts higher education of tomorrow.

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The Liberal Arts Institution and the Scaled Online Learning Platform Provider | Learning Innovation - Inside Higher Ed