A team of neuroscientists at the University of Wisconsin claim to have found a way to control how high mice can get on a given amount of cocaine.
And don't worry — while that may sound like a particularly frivolous plot concocted by a team of evil scientists, the goal of the research is well-meaning.
The team, led by University of Wisconsin neuroscientist Santiago Cuesta, was investigating how the gut microbiome can influence how mice and humans react to ingesting the drug.
The research, detailed in a new paper published this week in the journal Cell Host & Microbe, sheds light on a vicious feedback loop that could explain cases of substance abuse disorders — and possibly lay the groundwork for future therapeutic treatments.
In a number of experiments on mice, the researchers found that cocaine was linked to the growth of common gut bacteria, which feed on glycine, a chemical that facilitates basic brain functions.
The lower the levels of glycine in the brain, the more the mice reacted to the cocaine, exhibiting abnormal behaviors.
To test the theory, the scientists injected the mice with a genetically modified amino acid which cannot break down glycine. As a result, the behavior of mice returned to normal levels.
In other words, the amino acid could curb cocaine addiction-like behaviors — at least in animal models.
"The gut bacteria are consuming all of the glycine and the levels are decreasing systemically and in the brain," said Vanessa Sperandio, senior author, and microbiologist from the University of Wisconsin, in a statement. "It seems changing glycine overall is impacting the glutamatergic synapses that make the animals more prone to develop addiction."
It's an unorthodox approach to treating addiction, but could be intriguing — if it works in people, that is.
"Usually, for neuroscience behaviors, people are not thinking about controlling the microbiota, and microbiota studies usually don't measure behaviors, but here we show they’re connected," Cuesta added. "Our microbiome can actually modulate psychiatric or brain-related behaviors."
In short, their research could lead to new ways of treating various psychiatric disorders such as substance use by adjusting the gut microbiome and not making changes to the brain chemistry.
"I think the bridging of these communities is what's going to move the field forward, advancing beyond correlations towards causations for the different types of psychiatric disorders," Sperandio argued.
READ MORE: How gut bacteria influence the effects of cocaine in mice [Cell Press]
More on addiction: Study: Magic Mushrooms Helped 83% of People Cut Excessive Drinking
The post Scientists Found a Way to Control How High Mice Got on Cocaine appeared first on Futurism.
Follow this link:
Scientists Found a Way to Control How High Mice Got on Cocaine
- Classic reasoning systems like Loom and PowerLoom vs. more modern systems based on probalistic networks - November 8th, 2009 [November 8th, 2009]
- Using Amazon's cloud service for computationally expensive calculations - November 8th, 2009 [November 8th, 2009]
- Software environments for working on AI projects - November 8th, 2009 [November 8th, 2009]
- New version of my NLP toolkit - November 8th, 2009 [November 8th, 2009]
- Semantic Web: through the back door with HTML and CSS - November 8th, 2009 [November 8th, 2009]
- Java FastTag part of speech tagger is now released under the LGPL - November 8th, 2009 [November 8th, 2009]
- Defining AI and Knowledge Engineering - November 8th, 2009 [November 8th, 2009]
- Great Overview of Knowledge Representation - November 8th, 2009 [November 8th, 2009]
- Something like Google page rank for semantic web URIs - November 8th, 2009 [November 8th, 2009]
- My experiences writing AI software for vehicle control in games and virtual reality systems - November 8th, 2009 [November 8th, 2009]
- The URL for this blog has changed - November 8th, 2009 [November 8th, 2009]
- I have a new page on Knowledge Management - November 8th, 2009 [November 8th, 2009]
- N-GRAM analysis using Ruby - November 8th, 2009 [November 8th, 2009]
- Good video: Knowledge Representation and the Semantic Web - November 8th, 2009 [November 8th, 2009]
- Using the PowerLoom reasoning system with JRuby - November 8th, 2009 [November 8th, 2009]
- Machines Like Us - November 8th, 2009 [November 8th, 2009]
- RapidMiner machine learning, data mining, and visualization tool - November 8th, 2009 [November 8th, 2009]
- texai.org - November 8th, 2009 [November 8th, 2009]
- NLTK: The Natural Language Toolkit - November 8th, 2009 [November 8th, 2009]
- My OpenCalais Ruby client library - November 8th, 2009 [November 8th, 2009]
- Ruby API for accessing Freebase/Metaweb structured data - November 8th, 2009 [November 8th, 2009]
- Protégé OWL Ontology Editor - November 8th, 2009 [November 8th, 2009]
- New version of Numenta software is available - November 8th, 2009 [November 8th, 2009]
- Very nice: Elsevier IJCAI AI Journal articles now available for free as PDFs - November 8th, 2009 [November 8th, 2009]
- Verison 2.0 of OpenCyc is available - November 8th, 2009 [November 8th, 2009]
- What’s Your Biggest Question about Artificial Intelligence? [Article] - November 8th, 2009 [November 8th, 2009]
- Minimax Search [Knowledge] - November 8th, 2009 [November 8th, 2009]
- Decision Tree [Knowledge] - November 8th, 2009 [November 8th, 2009]
- More AI Content & Format Preference Poll [Article] - November 8th, 2009 [November 8th, 2009]
- New Planners Solve Rescue Missions [News] - November 8th, 2009 [November 8th, 2009]
- Neural Network Learns to Bluff at Poker [News] - November 8th, 2009 [November 8th, 2009]
- Pushing the Limits of Game AI Technology [News] - November 8th, 2009 [November 8th, 2009]
- Mining Data for the Netflix Prize [News] - November 8th, 2009 [November 8th, 2009]
- Interview with Peter Denning on the Principles of Computing [News] - November 8th, 2009 [November 8th, 2009]
- Decision Making for Medical Support [News] - November 8th, 2009 [November 8th, 2009]
- Neural Network Creates Music CD [News] - November 8th, 2009 [November 8th, 2009]
- jKilavuz - a guide in the polygon soup [News] - November 8th, 2009 [November 8th, 2009]
- Artificial General Intelligence: Now Is the Time [News] - November 8th, 2009 [November 8th, 2009]
- Apply AI 2007 Roundtable Report [News] - November 8th, 2009 [November 8th, 2009]
- What Would You do With 80 Cores? [News] - November 8th, 2009 [November 8th, 2009]
- Software Finds Learning Language Child's Play [News] - November 8th, 2009 [November 8th, 2009]
- Artificial Intelligence in Games [Article] - November 8th, 2009 [November 8th, 2009]
- Artificial Intelligence Resources - November 8th, 2009 [November 8th, 2009]
- Alan Turing: Mathematical Biologist? - April 25th, 2012 [April 25th, 2012]
- BBC Horizon: The Hunt for AI ( Artificial Intelligence ) - Video - April 30th, 2012 [April 30th, 2012]
- Can computers have true artificial intelligence" Masonic handshake" 3rd-April-2012 - Video - April 30th, 2012 [April 30th, 2012]
- Kevin B. Korb - Interview - Artificial Intelligence and the Singularity p3 - Video - April 30th, 2012 [April 30th, 2012]
- Artificial Intelligence - 6 Month Anniversary - Video - April 30th, 2012 [April 30th, 2012]
- Science Breakthroughs - April 30th, 2012 [April 30th, 2012]
- Hitman: Blood Money - Part 49 - Stupid Artificial Intelligence! - Video - April 30th, 2012 [April 30th, 2012]
- Research Members Turned Off By HAARP Artificial Intelligence - Video - April 30th, 2012 [April 30th, 2012]
- Artificial Intelligence Lecture No. 5 - Video - April 30th, 2012 [April 30th, 2012]
- The Artificial Intelligence Laboratory, 2012 - Video - April 30th, 2012 [April 30th, 2012]
- Charlie Rose - Artificial Intelligence - Video - April 30th, 2012 [April 30th, 2012]
- Expert on artificial intelligence to speak at EPIIC Nights dinner - May 4th, 2012 [May 4th, 2012]
- Filipino software engineers complete and best thousands on Stanford’s Artificial Intelligence Course - May 4th, 2012 [May 4th, 2012]
- Vodafone xone™ Hackathon Challenges Developers and Entrepreneurs to Build a New Generation of Artificial Intelligence ... - May 4th, 2012 [May 4th, 2012]
- Rocket Fuel Packages Up CPG Booster - May 4th, 2012 [May 4th, 2012]
- 2 Filipinos finishes among top in Stanford’s Artificial Intelligence course - May 5th, 2012 [May 5th, 2012]
- Why Your Brain Isn't A Computer - May 5th, 2012 [May 5th, 2012]
- 2 Pinoy software engineers complete Stanford's AI course - May 7th, 2012 [May 7th, 2012]
- Percipio Media, LLC Proudly Accepts Partnership With MIT's Prestigious Computer Science And Artificial Intelligence ... - May 10th, 2012 [May 10th, 2012]
- Google Driverless Car Ok'd by Nevada - May 10th, 2012 [May 10th, 2012]
- Moving Beyond the Marketing Funnel: Rocket Fuel and Forrester Research Announce Free Webinar - May 10th, 2012 [May 10th, 2012]
- Rocket Fuel Wins 2012 San Francisco Business Times Tech & Innovation Award - May 13th, 2012 [May 13th, 2012]
- Internet Week 2012: Rocket Fuel to Speak at OMMA RTB - May 16th, 2012 [May 16th, 2012]
- How to Get the Most Out of Your Facebook Ads -- Rocket Fuel's VP of Products, Eshwar Belani, to Lead MarketingProfs ... - May 16th, 2012 [May 16th, 2012]
- The Digital Disruptor To Banking Has Just Gone International - May 16th, 2012 [May 16th, 2012]
- Moving Beyond the Marketing Funnel: Rocket Fuel Announce Free Webinar Featuring an Independent Research Firm - May 23rd, 2012 [May 23rd, 2012]
- MASA Showcases Latest Version of MASA SWORD for Homeland Security Markets - May 23rd, 2012 [May 23rd, 2012]
- Bluesky Launches Drones for Aerial Surveying - May 23rd, 2012 [May 23rd, 2012]
- Artificial Intelligence: What happened to the hunt for thinking machines? - May 25th, 2012 [May 25th, 2012]
- Bubble Robots Move Using Lasers [VIDEO] - May 25th, 2012 [May 25th, 2012]
- UHV assistant professors receive $10,000 summer research grants - May 27th, 2012 [May 27th, 2012]
- Artificial intelligence: science fiction or simply science? - May 28th, 2012 [May 28th, 2012]
- Exetel taps artificial intelligence - May 29th, 2012 [May 29th, 2012]
- Software offers brain on the rain - May 29th, 2012 [May 29th, 2012]
- New Dean of Science has high hopes for his faculty - May 30th, 2012 [May 30th, 2012]
- Cognitive Code Announces "Silvia For Android" App - May 31st, 2012 [May 31st, 2012]
- A Rat is Smarter Than Google - June 5th, 2012 [June 5th, 2012]