LONDON The world's leading drug companies are turning to artificial intelligence to improve the hit-and-miss business of finding new medicines, with GlaxoSmithKline unveiling a new $43 million deal in the field on Sunday.
Other pharmaceutical giants including Merck & Co, Johnson & Johnson and Sanofi are also exploring the potential of artificial intelligence (AI) to help streamline the drug discovery process.
The aim is to harness modern supercomputers and machine learning systems to predict how molecules will behave and how likely they are to make a useful drug, thereby saving time and money on unnecessary tests.
AI systems already play a central role in other high-tech areas such as the development of driverless cars and facial recognition software.
"Many large pharma companies are starting to realize the potential of this approach and how it can help improve efficiencies," said Andrew Hopkins, chief executive of privately owned Exscientia, which announced the new tie-up with GSK.
Hopkins, who used to work at Pfizer, said Exscientia's AI system could deliver drug candidates in roughly one-quarter of the time and at one-quarter of the cost of traditional approaches.
The Scotland-based company, which also signed a deal with Sanofi in May, is one of a growing number of start-ups on both sides of the Atlantic that are applying AI to drug research. Others include U.S. firms Berg, Numerate, twoXAR and Atomwise, as well as Britain's BenevolentAI.
"In pharma's eyes these companies are essentially digital biotechs that they can strike partnerships with and which help feed the pipeline," said Nooman Haque, head of life sciences at Silicon Valley Bank in London.
"If this technology really proves itself, you may start to see M&A with pharma, and closer integration of these AI engines into pharma R&D."
STILL TO BE PROVEN
It is not the first time drugmakers have turned to high-tech solutions to boost R&D productivity.
The introduction of "high throughput screening", using robots to rapidly test millions of compounds, generated mountains of leads in the early 2000s but notably failed to solve inefficiencies in the research process.
When it comes to AI, big pharma is treading cautiously, in the knowledge that the technology has yet to demonstrate it can successfully bring a new molecule from computer screen to lab to clinic and finally to market.
"It's still to be proven, but we definitely think we should do the experiment," said John Baldoni, GSK's head of platform technology and science.
Baldoni is also ramping up in-house AI investment at the drugmaker by hiring some unexpected staff with appropriate computing and data handling experience - including astrophysicists.
His goal is to reduce the time it takes from identifying a target for disease intervention to finding a molecule that acts against it from an average 5.5 years today to just one year in future.
"That is a stretch. But as we've learnt more about what modern supercomputers can do, we've gained more confidence," Baldoni told Reuters. "We have an obligation to reduce the cost of drugs and reduce the time it takes to get medicines to patients."
Earlier this year GSK also entered a collaboration with the U.S. Department of Energy and National Cancer Institute to accelerate pre-clinical drug development through use of advanced computational technologies.
The new deal with Exscientia will allow GSK to search for drug candidates for up to 10 disease-related targets. GSK will provide research funding and make payments of 33 million pounds ($43 million), if pre-clinical milestones are met.
(Reporting by Ben Hirschler; Editing by Adrian Croft/Keith Weir)
TORONTO The U.S government warned industrial firms this week about a hacking campaign targeting the nuclear and energy sectors, the latest event to highlight the power industry's vulnerability to cyber attacks.
Data-sharing business Dropbox Inc is seeking to hire underwriters for an initial public offering that could come later this year, which would make it the biggest U.S. technology company to go public since Snap Inc , people familiar with the matter said on Friday.
Go here to read the rest:
Big pharma turns to AI to speed drug discovery, GSK signs deal - Reuters
- Classic reasoning systems like Loom and PowerLoom vs. more modern systems based on probalistic networks - November 8th, 2009 [November 8th, 2009]
- Using Amazon's cloud service for computationally expensive calculations - November 8th, 2009 [November 8th, 2009]
- Software environments for working on AI projects - November 8th, 2009 [November 8th, 2009]
- New version of my NLP toolkit - November 8th, 2009 [November 8th, 2009]
- Semantic Web: through the back door with HTML and CSS - November 8th, 2009 [November 8th, 2009]
- Java FastTag part of speech tagger is now released under the LGPL - November 8th, 2009 [November 8th, 2009]
- Defining AI and Knowledge Engineering - November 8th, 2009 [November 8th, 2009]
- Great Overview of Knowledge Representation - November 8th, 2009 [November 8th, 2009]
- Something like Google page rank for semantic web URIs - November 8th, 2009 [November 8th, 2009]
- My experiences writing AI software for vehicle control in games and virtual reality systems - November 8th, 2009 [November 8th, 2009]
- The URL for this blog has changed - November 8th, 2009 [November 8th, 2009]
- I have a new page on Knowledge Management - November 8th, 2009 [November 8th, 2009]
- N-GRAM analysis using Ruby - November 8th, 2009 [November 8th, 2009]
- Good video: Knowledge Representation and the Semantic Web - November 8th, 2009 [November 8th, 2009]
- Using the PowerLoom reasoning system with JRuby - November 8th, 2009 [November 8th, 2009]
- Machines Like Us - November 8th, 2009 [November 8th, 2009]
- RapidMiner machine learning, data mining, and visualization tool - November 8th, 2009 [November 8th, 2009]
- texai.org - November 8th, 2009 [November 8th, 2009]
- NLTK: The Natural Language Toolkit - November 8th, 2009 [November 8th, 2009]
- My OpenCalais Ruby client library - November 8th, 2009 [November 8th, 2009]
- Ruby API for accessing Freebase/Metaweb structured data - November 8th, 2009 [November 8th, 2009]
- Protégé OWL Ontology Editor - November 8th, 2009 [November 8th, 2009]
- New version of Numenta software is available - November 8th, 2009 [November 8th, 2009]
- Very nice: Elsevier IJCAI AI Journal articles now available for free as PDFs - November 8th, 2009 [November 8th, 2009]
- Verison 2.0 of OpenCyc is available - November 8th, 2009 [November 8th, 2009]
- What’s Your Biggest Question about Artificial Intelligence? [Article] - November 8th, 2009 [November 8th, 2009]
- Minimax Search [Knowledge] - November 8th, 2009 [November 8th, 2009]
- Decision Tree [Knowledge] - November 8th, 2009 [November 8th, 2009]
- More AI Content & Format Preference Poll [Article] - November 8th, 2009 [November 8th, 2009]
- New Planners Solve Rescue Missions [News] - November 8th, 2009 [November 8th, 2009]
- Neural Network Learns to Bluff at Poker [News] - November 8th, 2009 [November 8th, 2009]
- Pushing the Limits of Game AI Technology [News] - November 8th, 2009 [November 8th, 2009]
- Mining Data for the Netflix Prize [News] - November 8th, 2009 [November 8th, 2009]
- Interview with Peter Denning on the Principles of Computing [News] - November 8th, 2009 [November 8th, 2009]
- Decision Making for Medical Support [News] - November 8th, 2009 [November 8th, 2009]
- Neural Network Creates Music CD [News] - November 8th, 2009 [November 8th, 2009]
- jKilavuz - a guide in the polygon soup [News] - November 8th, 2009 [November 8th, 2009]
- Artificial General Intelligence: Now Is the Time [News] - November 8th, 2009 [November 8th, 2009]
- Apply AI 2007 Roundtable Report [News] - November 8th, 2009 [November 8th, 2009]
- What Would You do With 80 Cores? [News] - November 8th, 2009 [November 8th, 2009]
- Software Finds Learning Language Child's Play [News] - November 8th, 2009 [November 8th, 2009]
- Artificial Intelligence in Games [Article] - November 8th, 2009 [November 8th, 2009]
- Artificial Intelligence Resources - November 8th, 2009 [November 8th, 2009]
- Alan Turing: Mathematical Biologist? - April 25th, 2012 [April 25th, 2012]
- BBC Horizon: The Hunt for AI ( Artificial Intelligence ) - Video - April 30th, 2012 [April 30th, 2012]
- Can computers have true artificial intelligence" Masonic handshake" 3rd-April-2012 - Video - April 30th, 2012 [April 30th, 2012]
- Kevin B. Korb - Interview - Artificial Intelligence and the Singularity p3 - Video - April 30th, 2012 [April 30th, 2012]
- Artificial Intelligence - 6 Month Anniversary - Video - April 30th, 2012 [April 30th, 2012]
- Science Breakthroughs - April 30th, 2012 [April 30th, 2012]
- Hitman: Blood Money - Part 49 - Stupid Artificial Intelligence! - Video - April 30th, 2012 [April 30th, 2012]
- Research Members Turned Off By HAARP Artificial Intelligence - Video - April 30th, 2012 [April 30th, 2012]
- Artificial Intelligence Lecture No. 5 - Video - April 30th, 2012 [April 30th, 2012]
- The Artificial Intelligence Laboratory, 2012 - Video - April 30th, 2012 [April 30th, 2012]
- Charlie Rose - Artificial Intelligence - Video - April 30th, 2012 [April 30th, 2012]
- Expert on artificial intelligence to speak at EPIIC Nights dinner - May 4th, 2012 [May 4th, 2012]
- Filipino software engineers complete and best thousands on Stanford’s Artificial Intelligence Course - May 4th, 2012 [May 4th, 2012]
- Vodafone xone™ Hackathon Challenges Developers and Entrepreneurs to Build a New Generation of Artificial Intelligence ... - May 4th, 2012 [May 4th, 2012]
- Rocket Fuel Packages Up CPG Booster - May 4th, 2012 [May 4th, 2012]
- 2 Filipinos finishes among top in Stanford’s Artificial Intelligence course - May 5th, 2012 [May 5th, 2012]
- Why Your Brain Isn't A Computer - May 5th, 2012 [May 5th, 2012]
- 2 Pinoy software engineers complete Stanford's AI course - May 7th, 2012 [May 7th, 2012]
- Percipio Media, LLC Proudly Accepts Partnership With MIT's Prestigious Computer Science And Artificial Intelligence ... - May 10th, 2012 [May 10th, 2012]
- Google Driverless Car Ok'd by Nevada - May 10th, 2012 [May 10th, 2012]
- Moving Beyond the Marketing Funnel: Rocket Fuel and Forrester Research Announce Free Webinar - May 10th, 2012 [May 10th, 2012]
- Rocket Fuel Wins 2012 San Francisco Business Times Tech & Innovation Award - May 13th, 2012 [May 13th, 2012]
- Internet Week 2012: Rocket Fuel to Speak at OMMA RTB - May 16th, 2012 [May 16th, 2012]
- How to Get the Most Out of Your Facebook Ads -- Rocket Fuel's VP of Products, Eshwar Belani, to Lead MarketingProfs ... - May 16th, 2012 [May 16th, 2012]
- The Digital Disruptor To Banking Has Just Gone International - May 16th, 2012 [May 16th, 2012]
- Moving Beyond the Marketing Funnel: Rocket Fuel Announce Free Webinar Featuring an Independent Research Firm - May 23rd, 2012 [May 23rd, 2012]
- MASA Showcases Latest Version of MASA SWORD for Homeland Security Markets - May 23rd, 2012 [May 23rd, 2012]
- Bluesky Launches Drones for Aerial Surveying - May 23rd, 2012 [May 23rd, 2012]
- Artificial Intelligence: What happened to the hunt for thinking machines? - May 25th, 2012 [May 25th, 2012]
- Bubble Robots Move Using Lasers [VIDEO] - May 25th, 2012 [May 25th, 2012]
- UHV assistant professors receive $10,000 summer research grants - May 27th, 2012 [May 27th, 2012]
- Artificial intelligence: science fiction or simply science? - May 28th, 2012 [May 28th, 2012]
- Exetel taps artificial intelligence - May 29th, 2012 [May 29th, 2012]
- Software offers brain on the rain - May 29th, 2012 [May 29th, 2012]
- New Dean of Science has high hopes for his faculty - May 30th, 2012 [May 30th, 2012]
- Cognitive Code Announces "Silvia For Android" App - May 31st, 2012 [May 31st, 2012]
- A Rat is Smarter Than Google - June 5th, 2012 [June 5th, 2012]