MiG-31 Foxhound Is One Really Fast Russian Jet – 19FortyFive

When the MiG-25 Foxbat entered service with the Soviet Union in 1970, it gave NATO airpower planners plenty to worry about. The Foxbat was the fastest interceptor in the world at the time, and the ever-pervasive fear of the unknown flew alongside it. However, much of that fear dissipated after the defection of MiG-25 pilot Lt. Viktor Belenko in 1976. Belenko helped to eliminate the aura of mystery that had surrounded this high-speed aircraft.

But the Soviet war machine didnt let Belenkos defection deter them from improving on the concept. Thus the MiG-31 Foxhound was born.

From Foxbat to Foxhound

The Foxhound made her maiden flight in September 1975 and officially entered into service with the Soviet PVO (voyska protivovozdushnoy oborony, or Anti-Air Defense Troops) in 1981.

The MiG-31 bears a striking cosmetic resemblance to the MiG-25, which probably explains at least in part why NATO retained the Fox portion when assigning its codename to the successor aircraft. However, look beneath the surface and you will find the Foxhound equipped with state-of-the-art digital avionics that its older foxy sibling lacked.

For one thing, the MiG-31 was the first Soviet fighter aircraft to have true look-down/shoot-down capability, thanks to its phased array radar. Earlier USSR fighter radars had a tendency to run afoul of ground clutter. In addition, the Foxhound can work efficiently in all weather conditions while fulfilling visual flight rules and instrument flight rules, day and night.

Yet another improvement was the newer planes extended range, which increased to 1,900 miles (3,000 kilometers) upon initial takeoff, and further bolstered to 3,400 miles (5,400 kilometers) with one aerial refueling. By contrast, the gas-guzzling Foxbat bore the curse of a relatively short range: 1,160 miles (1,860 kilometers) at Mach 0.9 and 1,013 miles (1,630 kilometers) when zipping along at Mach 2.35. This underscored how lucky the aforementioned Belenko was to make his initial escape from Vladivostok to Hokkaido, Japan. (In retrospect, perhaps NATO shouldve codenamed the MiG-25 the Cheetah. It can pursue its prey at tremendous speeds, but only for short distances.)

The Foxhounds pilots also enjoyed a reduced likelihood of failure to communicate. As my 1945 colleague Caleb Larson explains,MiG-31s can network with other airplanes in their sortie, relaying information on enemy aircraft locations and thus covering a much wider area than unnetworked groups of airplanes.

Foxhound Flies On

Five hundred and nineteen Foxhounds have been produced so far, out of which 370 were delivered to the Russian Air Force and 30 are in service with Kazakh air force. In July 2020, Russias Defense Ministry announced its intention to invest in modernization and life extension programs for its MiG-31 fleet.

MiG-31 customers outside of the former Soviet republics have been few and far between. In 1992, right on the heels of the collapse of the Soviet Union, the cash-starved post-Soviet Russian arms industry offered the Mig-31 to Finland, but the Finns turned it down. Meanwhile, Syria ordered eight MiG-31E airframes for its own air force in 2007, but the order was suspended in May 2007. Six of these MiGs may or not have been delivered to Syria as of August 2015, depending on whether you choose to believe the Turkish or the Russian media.

What is not in dispute is that the Russians themselves have deployed the MiG-31 in missions over Syria. In addition, the Foxhound has been blooded in Vladimir Putins so-called special military operation in Ukraine. On March 18, a MiG-31K variant launched a strike on a Ukrainian arms depot near the Polish border, evidently using a Kh-47M2 Kinzhal hypersonic missile. In turn, on April 26, the Ukrainians managed to shoot down a Foxhound with a British-made Starstreak missile.

Specifications

General Characteristics

Crew: Two (pilot and weapons system officer)

Length: 22.69 m (74 ft 5 in)

Wingspan: 13.46 m (44 ft 2 in)

Height: 6.15 m (20 ft 2 in)

Wing area: 61.6 m (663 ft)

Empty weight: 21,820 kg (48,100 lb)

Armament

1 GSh-6-23 23 mm cannon with 260 rounds.

Fuselage recesses for 4 R-33 (AA-9 Amos) (or for MiG-31M/BM only 6 R-37 (AA-X-13 Arrow) long-range air-to-air missiles)

4 underwing pylons for a combination of:

Christian D. Orr is a former Air Force officer, Federal law enforcement officer, and private military contractor (with assignments worked in Iraq, the United Arab Emirates, Kosovo, Japan, Germany, and the Pentagon). Chris holds a B.A. in International Relations from the University of Southern California (USC) and an M.A. in Intelligence Studies (concentration in Terrorism Studies) from American Military University (AMU). He has also been published in The Daily Torch and The Journal of Intelligence and Cyber Security.

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MiG-31 Foxhound Is One Really Fast Russian Jet - 19FortyFive

H1 secures an extension on its Series C to further its mission of creating a healthier future through the use of connected and accessible healthcare…

NEW YORK, June 09, 2022 (GLOBE NEWSWIRE) -- H1, the connecting force for global healthcare professional, clinical, science, and research information, announced today that it raised a Series C extension bringing the total Series C raise to $123 million. H1s valuation holds strong at $773 million to-date. The funding extends H1s runway, allowing them to lean into its growth.

In a time of volatile markets when many are struggling to secure funding, this extension is a vote of confidence in our ability to advance our mission, said Ariel Katz, CEO and co-founder of H1. Our ability to raise capital at the same terms as our original Series C close is a testament to our significant market opportunity and ability to execute against it. Our platform has enabled our 200+ clients to gain greater insights and get groundbreaking treatments and therapies to patients around the world efficiently. We have improved access to healthcare for millions of patients, and dont intend to slow down. This additional funding allows us to control our own destiny and continue to innovate.

H1s mission is to create a healthier future by democratizing access to global expertise, groundbreaking research, discoveries, and connected insights for all doctors, R&D, industry, and, ultimately, patients. The H1 Connect platform combines data science and technology to synthesize billions of data points, including data on over ten million healthcare providers, 20,000 institutions, 25 million peer-reviewed publications, 420,000 clinical trials, two billion procedures, three billion diagnoses, and over nine million global claims. H1 Connect powers H1s portfolio of solutions including HCP Universe, Trial Landscape, Carevoyance, Precise, and Faculty Opinions.

We see a critical need for H1s global healthcare network, especially when it comes to improving diversity in clinical trials and improving healthcare equity, said Chase Williams, Goldman Sachs. H1s technology already powers a number of critical use cases for large healthcare organizations, and we believe they are uniquely positioned to realize their vision of becoming the central source of truth for actionable data on doctors, research, and treatments.

H1 graduated from Y Combinator in January 2020 as a bootstrapped company under ten employees, and in less than a year had closed on $70 million in total financing and employed more than 200 people. In November 2021, H1 announced a $100 million Series C round led by Altimeter Capital and joined by new investors Goldman Sachs Asset Management and Flex Capital, with participation from existing investors IVP, Menlo Ventures, Transformation Capital, Lux Capital, and LeadEdge. In July 2021, H1 acquired Carevoyance based in Oregon, extending its reach into medical devices, and, most recently in February 2022, acquired London-based Faculty Opinions Ltd. to broaden its global doctor network and further improve healthcare by bringing all data under one umbrella.

H1 has been continually recognized as an innovator in the healthcare technology space, most recently earning coveted spots on the Forbes' Best Startup Employers 2022 list, the 2022 Forbes 30 Under 30 list, and the NYC Digital Health 100 list. H1 supports more than 250 customers including top pharmaceutical companies, and as of Q1 2022, the companys annual recurring revenue (ARR) increased by approximately 140% as the appetite for healthcare data continued to accelerate and the network effect took hold.

Learn more about how H1 is powering the democratization of global healthcare data and making healthcare more equitable.

About H1H1 is the connecting force for global HCP, clinical, scientific and research information. The H1 Connect platform democratizes access to HCP knowledge and groundbreaking insights for life sciences, academic medical institutions, health systems, and payors. H1 Connect fuels a robust product suite that helps customers discover and engage industry experts, drive equitable research, access groundbreaking science, and accelerate commercial success with the most robust and accurate healthcare professional data. Learn more at h1.co.

Media Contact:Anya NelsonScratch Marketing + Media for H1anyan@scratchmm.com M: 617.817.6559

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Bengaluru: NAL marks 55 years of 1.2m trisonic wind tunnel – The Indian Express

The National Aerospace Laboratories (NAL) in Bengaluru on Sunday marked 55 years of the 1.2mm trisonic wind tunnel, the only industrial wind tunnel providing the high-speed aerodynamic data for national aerospace programmes, both in the civil and military sectors.

Wind tunnels are used for simulating flight conditions in the laboratory. The NAL stated that the facility will continue to meet the experimental aerodynamic data requirement of future programmes.

Council of Scientific and Industrial Research (CSIR)-NAL is currently working towards setting up a continuous wind tunnel facility to meet the increased demand for high speed experimental aerodynamic data. Practically each and every indigenously developed aerospace vehicle in the country has graduated out of this facility. To cater to the emerging requirements of the country, continual upgrades of the facility have been implemented in CSIR-NAL, leading to many state-of-the-art techniques related to high-speed wind tunnel testing mainly to improve the data quality, productivity and life extension of various components of the wind tunnel, a statement from CSIR-NAL read.

The 1.2m trisonic wind tunnel was built by the CSIR between 1963 and 1967. The first blow-down (test) was conducted on May 29, 1967. The vision of the late Dr P Neelakantan, the first Director of CSIR-NAL, enabled the realisation of this facility, which is the major workhorse for all the national aerospace programmes. The highest speed of this tunnel is Mach 4.0 which is four times the speed of sound, the release said.

The mission of this facility is to provide advanced technology solutions to national aerospace programs, fighter aircraft, defence systems, launch vehicles and satellites and space systems.

This wind tunnel was primarily conceived for research and development in experimental aerodynamics. Subsequently, as the Indian Space Research Organization (ISRO) and Defence Research and Development Organization (DRDO) started the development of launch vehicles, missiles and aircraft, the need for high-speed wind tunnel tests in the 1.2m wind tunnel increased. To name a few, DRDOs missiles such as Agni, Akaash, Prithvi, Pralay, SRSAM, LRSAM, ASTRA, NAG, LRAShM, BrahMos, Nirbhay, Unmanned Aerial Vehicles, etc. were characterized in this facility.

Similarly, aerodynamic characterisation of the ISROs launch vehicles such as ASLV, PSLV, SLV, SSLV, GSLV, RLV and GAGANYAAN programmes were carried out extensively. The nations first Light Combat Aircraft (LCA-TEJAS) was conceived at this facility and now it is flying in the sky. Many weapon integration programmes on LCA, Mirage-2000, Sukhoi-30, Jaguar, MiG aircraft etc., were successfully carried out in this facility.

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Bengaluru: NAL marks 55 years of 1.2m trisonic wind tunnel - The Indian Express

What is Posthumanism, and Why Should You Care? | Thoughtful Play

Welcome to Posthumanism and Video Games. The purpose of this project, conducted by St. Olaf undergraduates Anthony Dungan and Israa Khalifa, is to examine how numerous video games interact with posthumanism and what audiences can learn about posthuman ideas through video games.

At its core, posthumanism is a theoretical framework that wants to re-imagine what a human is or rethink humanitys place in society. Some posthumanists want to remove humanity as the center of existence and want to every object in existence to be treated equally; others consider what existence on Earth would be like if humanity went completely extinct. Some challenge the boundaries of the human body and want to extend or augment those capabilities through cybernetics; others consider the personhood of completely artificial beings like androids or artificial intelligence. For a more nuanced definition and understanding, see our glossary entry on posthumanism.

The fact is, humanity is already becoming a posthuman society. Cybernetic bodies arent some far-off concept, but rather something that exists already. There are recent advancements like cybernetic and prosthetic limbs, as well as enhancements that have been around for decades, like hearing aids. Artificial life is making significant progress as well. In 2017, the first robot became a citizen of a country, and robots are becoming more physically capable. Imagining an existence without humanity might not be that hard, considering the threat that global warming poses to society means Earth might very well be literally posthuman within a few hundred years.

In addition, scientific knowledge and technological advancements are historically situated. Keeping this in mind allows for an understanding of Western cultures long history of individualism, technological warfare, and the binarism between body and soul. Posthumanism rejects that binary and allows for a fuller understanding of the Wests obsession with a human and technological apocalypse or a techno-utopian world. In addition, posthumanism breaks free from the patriarchal and supremacist legacy created by Christianity in the Enlightenment as well as favoring humans over other objects. These legacies of the Enlightenment are directly linked to systematic oppression, racism, slavery, and wars all over the world. Posthumanism, to an extent, allows for alternative solutions or ways of thought to break free from these problems.

We could say something about how games are the most profitable medium in the modern entertainment industry. We could also say that video games reach an incredibly large audience, or a number of other reasons. The fact is, we researched video games because the medium allows players to directly interact with ideologies in a safe space. Unlike audiences in other mediums like film, literature, or music, players directly interact with whats happening. They dont just see fancy technology, they use it. Players are active participants in the messages they create, which is something unique to the medium of games. As games are a relatively young medium, researching the medium helps establish a better understanding of how games engage audiences in unique ways.

With that in mind, please enjoy the results of our research! You can read our analyses in any order, but if you want to be directed to a good beginning spot, Id recommend our podcast episode, Embodiment in Transistor. If youre interested in making your own Thoughtful Play project, contact thoughtfulplay@gmail.com. You can check out our glossary here, and if you want to check our sources, head over here.

Anthony Dungan has been playing video games for almost longer than he can remember. It all started when his parents would let him watch them play Star Wars video games, and his obsession that started then has only become more rabid. Almost two decades later, Anthony has started mixing academic work into his love of video games. After watching a thoughtful, engaging presentation on The Last of Us by a professor from St. Olaf College, Anthony knew that he had to attend St. Olaf to improve his writing skills and hopefully have a chance to engage in academic work on video games. This wish was granted, and resulted in Posthumanism and Rhetoric in Video Games.

Israa Khalifa studies sociology and anthropology at St. Olaf College.

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What is Posthumanism, and Why Should You Care? | Thoughtful Play

Open call: 2022 International Residency – Announcements – e-flux

Asia Culture Center (ACC) is pleased to announce the international open call for ACC Residency 2022. Applications are currently being accepted online with a submission deadline of June 13, 2022.

Under the theme of Post-COVID-19 Era, Posthumanism, ACC Residency 2022 seeks to interrogate issues such as the fourth industrial revolution in the contactless era, the changes in the notion of labor brought about by the digital transformation and the new relationship between humans and things (the post-human).

The Residency consists of five categories: Art & Technology, Visual Arts, Design, Theater, and Dialogue and is opened to all creators and researchers who have experience and capability to propose and implement a project exploring the theme.

ACC will support selected participants with workspaces, accommodation, a grant of 2,000,000KRW per month, and research/project funding up to 10,000,000KRW for Researchers and up to 50,000,000KRW for Creators. In addition, ACC will offer various resources from seminars, workshops to consulting sessions with experts as well as production facilities and audio-visual equipment in ACT Studio. ACC will work closely with the each participant and projects developed throughout the 5-month residency will be presented through showcase, exhibition and performance in December.

For more information and to apply, please visit ACCs website. The selection process will consist of two steps, application document review and interview through which around 27 individuals/teams are expected to be selected. The announcement will be made in July through ACC website.

Practical informationApplication period: May 23June 13,2022 (6:00pm KST)Apply onlineTheme: Post-COVID-19 Era, PosthumanismResidency period: August 2022December 2022 (5 months)Categories: Art & Technology, Visual Arts, Design, Theater, DialogueEligible applicants: Individuals/groups who have experience and potential and are actively involved in the relative fieldsSupportsGrant, project/research fund, and supporting programs.Presentation at group exhibition/showcase/academic event.Workspace, accommodation, and ACT centerAirfares for international participants

Materials to submitApplication form (including Personal Information Collection and Usage Agreement) in a provided form (.pdf)A project (or research) proposal in a provided form (.pdf)A portfolio in a provided form (.pdf, maximum 30 pages including the cover, not exceeding 50MB)A letter of recommendation (only for international applicants)

About Asia Culture Center and ACC ResidencyAsia Culture Center (ACC) located in Gwangju, South Korea, is an international arts and culture organization committed to bringing together and fostering exchange among different regions and disciplines. As one of its year-round programs, ACC Residency is a platform for research, creation and production that brings together creative talents from around the world to share their knowledge, technological insight and experience. Since 2015, it has supported the cross-disciplinary, inventive, and bold projects of more than 740 creators, designers, artists and researchers.

For more information, please visit acc.go.kr.

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Captive animals include pets | Opinion | dailyuw.com

Editors Note: Everyone designs. While not all design work is compensated, DIY Design strives to promote awareness of design processes in everyday life. Each week, Tatum Lindquist explores a new field or theory in the design world and relates it to the UW community as a way to live with intentionality and agency.

TikToker @justinbieberthecat_ showcases Justin, a cat, using extensive vocabulary via talking buttons to communicate with his owner. Some videos show Justin using the buttons beyond basic care requests to express discontent by pressing love you and no repetitively after his owner stopped playing with him to work. While adorable, the videos receive a range of responses, including skeptics who criticize Justins cognitive comprehension of the words hes trained to use.

However, humans may not yet possess the capabilities to even fully understand the extent of animals cognitive abilities, especially given that Justin and other animals can communicate beyond human perception. Limited in perception, humans may fail to fully understand the complex experiences of animals altogether. And in the design world, where the ethics of animal participation are muddled and gray, these limitations need consideration.

Posthumanism is a collection of theories, philosophies, and worldviews, or epistemologies, having to do with understanding the more-than-human inhabitants of our world, Kristin Dew, an assistant teaching professor of human centered design & engineering, said.

More-than-human encompasses both environmental and technological inhabitants and, as with any theory applied to design, posthumanism starts with questions and reflection. For me, it means deconstructing the human from human-centered design processes and opening up space for animal experiences, especially those captive in human society.

When people think about sites of captivity with animals, they almost never think of companion animals, Karen Emmerman, a philosophy lecturer, said. People forget that we're in this sort of relationship with them where we have made a lot of choices for them.

While zoos, laboratories, or aquariums may associate more closely with captivity, pet owners decide their animals diets, living conditions, reproductive abilities, and so on. Im not here advocating for you to stop making choices for your pet, because thats neither practical nor productive. The point that posthumanist design makes is to acknowledge the reality of our relationship with animals and the greater world.

The current age we live in, known as the Anthropocene, describes the ecological time where human activity irreversibly and significantly impacts the environment. Humans and our constructs and systems impact the nonhuman world, and for pets or other captive animals, it means trading some agency for survival.

I work in a theory thats called ecofeminist theory, which is basically looking at animals and ecological issues through the lens of feminist theory, Emmerman said. And in particular, what this means for animals is that the domination and exploitation of animals [are] connected to other forms of domination and exploitation.

That joke about how some pampered pets live in better conditions than people in lower socioeconomic statuses? That inequality directly ties into the inequality of wealth created by human constructs of wealth and capitalism. That trend asking people to show who lives in their home rent-free, and creators show their pet? Thats animals living under the same economic and social contexts as humans.

The ethics of how designs participate in systems of oppression extend beyond the humans impacted; these designs impact and can impose these same constructs on nonhumans. A valid critique arises when considering if humans should never use or keep animals, given that we cant even uphold the collective rights of historically marginalized communities.

However, this critique asks for perfection, a toxic ideal rooted in white supremacy. Posthumanism, instead, asks for the willingness to be wrong and make mistakes and to be held accountable in our personal relationships with companion animals.

Something like grief and regret, that we have to be in this kind of relationship with our animals, Emmerman said. Where can we find ways to really promote their agency and give them back control in any possible way that we can give it back to them?

As the owner of an emotional support animal, I hold a breadth of complex grief, gratitude, love, and care in how I benefit emotionally from my relationship with my cat. Given the constraints of society, the answer is not simply to never keep companion animals. For me, posthumanist design means promoting the agency of my cat and designing our habitat our home with her needs and desires in mind.

It means poking at the silliness of rearranging furniture and rooms so my cat can have her own personal space. It means pushing back against the cr-zy cat person stereotype, swallowing my pride, and taking my cat out for walks in a pet stroller because she wants to go outside. In its simplest form, this do-it-yourself posthumanist design asks: How can I respect the lived experiences of captive companion animals?

Reach writer Tatum Lindquist at opinion@dailyuw.edu. Twitter: @TatumLindquist

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What Was Deconstruction? – The Chronicle of Higher Education

In 1990, at the Humanities Research Institute at University of California at Irvine, I found myself sitting next to Jacques Derrida at a lecture given by Ernesto Laclau. The topic was Antonio Gramsci. At the end of the talk, of which I understood frustratingly little, Derrida asked a question that took about 20 minutes to formulate. Laclaus response was of equal length. This mattered, because the event was the only one open to the public (it was to be followed by an invitation-only seminar). Graduate students and professors packed the lecture hall and, like Laclau himself, deferentially hung on Derridas every word. But they never had time to speak. The episode struck me as symbolic of the reverence deconstruction commanded at the height of its influence and also of the hierarchies, buoyed by awestruck puzzlement, upon which it rested.

At a private reception the next day, I approached Derrida to press him on his comments, for his intervention at Laclaus lecture had, as far as I could tell, nothing to do with Gramsci. As I cited studies and quoted passages to support my point, Derrida looked up at me with quizzical eyes and a faint, perhaps condescending, smile. I was aware that my questions violated academic politesse, since to press the philosopher on issues about which he seemed ill-informed was impertinent. The underlying joke (which I also got, although I pretended not to) meant knowing that what Gramsci actually wrote, or why, hardly mattered at least here.

Now, 30 years down the road, it is surprisingly hard to remember why Derridas deconstruction a theory of reading with the unlikely catchphrase the metaphysics of presence swept all before it in English departments of the American heartland, prompted Newsweek to warn of its dramatic and destructive power, and moved prominent scholars like Ruth Marcus to denounce its semi-intelligible attacks on reason and truth. For decades the movements adages appeared as one-liners at Modern Language Association cash bars: literary language undoes its own premises, philosophy is the self-subversion of hierarchical oppositions. After all the high-powered careers, the junkets to Bellagio, the National Endowment for the Humanities cash, the Paul de Man scandal, and the hagiographies, its revolution has begun to seem less a bone of contention than the professions longest-running one-line joke.

To this day, deconstruction remains a style of thought more complained about than understood, less outrageous than deliberately elusive. Until the very end, its high-profile proponents contemptuously elected not to define it, insisting instead on its undefinability, which naturally led the unpersuaded (summoning a favorite movement term) to judge deconstruction an escomatage (a dodge or conjuring trick). After the revolution had become rote, critics no longer forced to bite their tongues pointed to Derridas wordplay (aigle for Hegel for instance; or hantologie for ontology), and noted that punning is the lowest form of humor. Could it be, some of us in the discipline began to wonder, that Derrida was the Herbert Spencer of our era a towering edifice in his time and a vacant epigone of Heidegger outside it?

The power of Gregory Jones-Katzs extraordinarily well-researched Deconstruction: An American Institution (University of Chicago Press, 2021), apart from dodging the extremes of obeisance and dismissal, is not to have adopted deconstructions aversion toward situating the movement in its time and place. He capably walks his reader through the fine-grained details of seminal texts, but also wisely moves beyond them, perhaps implying that the schools interest for us today lies less in its stable of familiar themes than in its improbable success. What made deconstruction soar when its philosophical points of departure, the genealogy of its methods, the clash between French and American intellectual culture, and the incompatible positions of its principal spokespersons were so poorly understood? The legacy of deconstruction seems to present us with two alternatives: It is either a story of a radical turn toward a reason freed from binary oppositions (man/woman, truth/falsity), or it is a conversion story with indecipherability its sacred sine qua non.

Grard Rondeau, Redux

In tackling this dilemma, Jones-Katz gives us plausible scenarios but leaves important ones unmentioned. Told as a story of ideas, deconstruction began with two unrelated moves. First, Derrida seized upon Husserls emphasis on the materiality of language, but also on Husserls timidity in reducing the sign to a mere representation, thereby diminishing its ontological force (writing, for Derrida, has material autonomy). Second, Paul de Man redirected the formalists emphasis on literary figures like irony, metonymy, and allegory to what he (confusingly) called rhetoric, which meant not the art of persuasion but the genetic, impersonal principle that literary texts dwell in contradiction and are thus impervious to resolution.

Told as a story of institutions, deconstruction took shape as the gathering of strong personalities who had the ears of their deans, and who nurtured these seeds into a program, a curriculum, and finally, a crusade. The power center featured Derrida, de Man, Geoffrey Hartman, J. Hillis Miller, and later, Barbara Johnson, and moved back and forth between Yale and Johns Hopkins, Cornell and (later) UC-Irvine, and its members saw themselves as the rescuers of a beleaguered literary studies which at the end of the postwar boom in the 1960s and 1970s was being pressured to defend its relevance and define its purpose. The profession was producing more Ph.D.s than jobs, and legislators were beginning to question the cost of higher education. At the same time, students honed to a sharp point by the civil-rights and feminist movements, as well as by opposition to the Vietnam War, demanded more than the aesthetic contemplation of a canon sealed off from the contagion of everyday life.

From the start, though, the deconstructive revolution was as self-contradictory as the literary language it studied. Touted as the mission of leftist radicals by the media, it was really the creation of midcareer professors at East Coast universities. Inspired by the New Left, it took its leads not from the policy-oriented, anti-colonial wing but the one decried by Thomas Frank for its lifestyle rebellions, obsessions with the personal, and hostility to all authority. While Jones-Katz does not exactly say so, the stage was set for deconstruction also by the threat of American scientism. In fields like eco-criticism, animal studies, and posthumanism that both mimic and deflect the sciences, Derrida remains immensely influential. There he is called upon, among other things, to virally infect communication and short-circuit the nature of thought itself. The book establishes, at any rate, that deconstruction was less a French invasion (as the media would have you believe) than an American invention, beginning with the recruitment of Derrida, lured to the United States only after his influence was beginning to wane in Europe and after the French minister of education denied him a chair at the University of Paris Nanterre.

As deconstruction developed over the 1980s and 1990s, its politics became harder and harder to read. For one thing, it was the brainchild of wildly different kinds of scholars: a literary romanticist and Nietzschean (de Man), a phenomenological philosopher (Derrida), a sociohistorical critic with Auerbachian beginnings (Hartman), an influence theorist (Harold Bloom), a critic of authorial consciousness (Miller), and feminists with affiliations ranging from new historicism and Lacanian psychoanalysis to Marxism (Johnson, Margaret Homans, Mary Poovey, Gayatri Chakravorty Spivak, and others). Unfortunately, Jones-Katz has nothing to say about the incoherence of this ensemble. Still, the jumble is the first sign that deconstruction, influential and enduring though it might be, is not what it seems.

Jones-Katz rightly observes, for example, that deconstruction sought to make criticism relevant to social needs. But then what could be more embarrassing in an era of trickle-down economics than a theory whose authority depended on an Ivy League seal of approval? The unseemly deference paid by the underfunded academic second-string toward New Haven theories packaged for the provinces was only matched by the indignant, but always eager, coverage of deconstructive antics in the mainstream press, ever alert to the goings-on at institutions with the smell of money (the outrageous professional perks, the cushy gigs, the Guggenheim Fellowships, the NEH and Ford Foundation largess, the island homes off the coast of Maine).

Deconstructions renovation of the humanities seemed equally at odds with its unmistakably religious undertones. Michel Foucault had already pointed out that giving writing a primal status and claiming writing as absence (two of Derridas signature moves) simply repeated the transcendental terms of the religious principle. (This is one reason Derrida remains influential among theologians.) Others took up this charge, wondering what an obsessive textualism based on the invisibility of all intention was if not Gnosticism. On the surface, deconstruction posed as a densely semantic investigation conducted with ruthless precision. And yet, all the while, it seemed to be playing a double game, winking at its readers by counting on them to recognize its Jesuitical, rabbinical, or Sufistic relationship to the Book.

Nominally a redoubt for vanguard critics, deconstruction in some quarters had the feel of an antiquarian rerun, part of that Gallic preciosity that Harry Levin dubbed the Alexandrianism of our time a return, in other words, to the obscure and ornamental writing of the last centuries before the Christian era; or perhaps to the exegetes of second-century Alexandria, among them Philo, who set out to prove that contradiction was the normal mode of all expression, and who proposed to undo the rational forms of Greek thought.

Although few could hear the point during theory fever, some observed that deconstructions attack on logocentrism created problems for liberatory politics. Barbara Harlow (one of Derridas early translators) observed that Western philosophy had, in fact, always given tendentious priority to the written word, to scripture, and the law not speech as Derrida contended. And what are Platos dialogues if not dissimulated speech skillfully managed in Socratess favor within the controlled ironies of writing? The technology of print in imperial Europe was the very brag of its civilization. How to escape, then, deconstructions implicit premise that peripheral traditions of storytelling, song, and word-of-mouth (what Ishmael Reed, after Booker T. Washington, called the grapevine telegraph) are illusory or nave? Texts for many cultures are oral, bodily, tonal, and rhythmic. They depend on communal gathering in short, on a metaphysics of presence.

One wishes Deconstruction in America had involved itself more with these kinds of interrogations. Its pages are given over too often to replaying mini-tussles at Yale or rehearsing minor essays. But Jones-Katz expresses well its principals considerable talents. The loyalty of de Mans students suggests a teacher whose dedication was, as it should be, legendary. Despite deconstructions bad rap, his essays on aesthetics and literary language are remarkably lucid, unpretentious, and pedagogically precise. Derridas erudition and attention to out-of-the-way texts, similarly, showed a creative, antinomian mind, and his powers to fashion syntax into the lure of an ever-receding referent to create the illusion of substance while ambiguating all referentiality was perhaps the highest mark of his brilliance.

At the same time, we need more theory than Jones-Katz provides to unpack deconstruction as theory. Ostensibly, we are exploring the ontology of language, but as the methodological incompatibility of its ensemble of practitioners implies, its real cohesion is not epistemological but ethical. The term deconstruction referred not to a set of philosophical concepts but to a desire, which was also a prescription, that there be (as Miller put it) no center, no head referent, no innermost core. In a post-radical era busy turning radicals into professionals, deconstruction with a great deal of philosophical noise fell back on Americas familiar modernist response to the partisans of all causes: There are no answers, no origins, no past, no perpetrators.

The move was deliberate. As Jones-Katz tells the story, de Mans teaching and mentorship were programmatic. Even an ally like Hartman reflected after his death: In the space war of the theorists, he became the Yoda figure, recruiting acolytes sent out into the profession to replicate his teachings. As Bloom complained, You clone, my dear. I dislike what you do as a teacher, because your students are as alike as two peas in a pod. With its Continental armature, deconstruction had the upper hand. Its adversaries were typically cast as uncharitable or clueless journalists, old-time empiricists, stale New Critics, or the Old World professoriate, handily dislodged (Ren Wellek, in particular, was a fall guy of this type).

Studiously avoided by its defenders was any mention of deconstructions formidable rivals and challengers: the literary sociology of Raymond Williams and Pierre Bourdieu; the materialist feminisms of Sylvia Wynter, Nancy Fraser, and Gayle Rubin; the more trenchant and capacious literary essays by Theodor Adorno, Leo Lowenthal, and Ernst Bloch; and the analytic philosopher John R. Searle, who deconstructed deconstruction with its own tools in The New York Review of Books to devastating and comic effect. Had deconstruction been more often forced to face the likes of Adornos demolition of Heideggers jargon of authenticity, it might have seemed more vulnerable.

As a body of propositions, it was never hard to probe deconstructions weaknesses. Texts undid themselves, it claimed, whereas it was really the deconstructive text that did and intentionally so. Denouncing something so amorphous and pretentious as Western metaphysics partook of the same reductions the school wanted to expose in other paradigms. What could be more damning than pointing out that deconstruction, against its own tenets, opposed opposition? This ultimate performative contradiction lay in claiming that semantic plenitude resists interpretation in the very act of writing that stood as proof of an effort to persuade. What its critics overlooked is that deconstruction triumphed in part by giving its readers less to think about. Its weaknesses gave it strength because running and dodging was its professed mode, so that pointing out its contradictions was a little like getting in its groove.

In this way, its politics seemed perfect for an American setting of plausible deniability. Feminism can apply deconstruction to male metaphysics and gendered and sexed hierarchical oppositions without having to reckon with the fact that in deconstruction metaphysics means the illusory belief that signifiers have worldly referents and hierarchy the taking of a stand, any stand. For Derrida, taking a position is itself hierarchical. The grievances of women can be addressed in deconstruction only at the cost of effacing all contestation. Deconstructions doctrine of interpretive play turns meaning over to a joyous, Nietzschean affirmation, which boils down to the claim that, like the Reagan administrations perverse reading of the SALT II treaty, anything goes.

In the end, deconstruction seems most American in giving repressive tolerance philosophical dignity. In a country where one can speak against the national nightmare so long as one is not heard, the only mainstream dissidence that probes the angry pulse of Americas fascist heart is found in stand-up comedy or fiction, where irony offers the safety of escape. As in the Monty Python sketch, the diligent truth-tellers of the alternative press are just so many Ernest Scribblers. Deconstruction won credence for the left by enlisting the European philosophical right; and was widely welcomed by the liberal center of academe because in attacking oppressive credos it was undermining credibility itself.

Link:

What Was Deconstruction? - The Chronicle of Higher Education

Saudi Arabia plans to spend $1 billion a year discovering treatments to slow aging – MIT Technology Review

The Saudi royal family has started a not-for-profit organization called the Hevolution Foundation that plans to spend up to $1 billion a year of its oil wealth supporting basic research on the biology of aging and finding ways to extend the number of years people live in good health, a concept known as health span.

The sum, if the Saudis can spend it, could make the Gulf state the largest single sponsor of researchers attempting to understand the underlying causes of agingand how it might be slowed down with drugs.

The foundation hasnt yet made a formal announcement, but the scope of its effort has been outlined at scientific meetings and is the subject of excited chatter among aging researchers, who hope it will underwrite large human studies of potential anti-aging drugs.

The fund is managed by Mehmood Khan, a former Mayo Clinic endocrinologist and the onetime chief scientist at PespsiCo, who was recruited to the CEO job in 2020. Our primary goal is to extend the period of healthy lifespan, Khan said in an interview. "There is not a bigger medical problem on the planet than this one.

MS TECH | GETTY

The idea, popular among some longevity scientists, is that if you can slow the body's aging process, you can delay the onset of multiple diseases and extend the healthy years people are able to enjoy as they grow older. Khan says the fund is going to give grants for basic scientific research on what causes aging, just as others have done, but it also plans to go a step further by supporting drug studies, including trials of treatments that are patent expired or never got commercialized.

We need to translate that biology to progress towards human clinical research. Ultimately, it wont make a difference until something appears in the market that actually benefits patients, Khan says.

Khan says the fund is authorized to spend up to $1 billion per year indefinitely, and will be able to take financial stakes in biotech companies. By comparison, the division of the US National Institute on Aging that supports basic research on the biology of aging spends about $325 million a year.

Hevolution hasnt announced what projects it will back, but people familiar with the group say it looked at funding a $100 million X Prize for age reversal technology and has reached a preliminary agreement to fund a test of the diabetes drug metformin in several thousand elderly people.

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Saudi Arabia plans to spend $1 billion a year discovering treatments to slow aging - MIT Technology Review

Never Take This After Age 50, Warn Pharmacists Eat This Not That – Eat This, Not That

Nutrition is crucial for healthy aging, but supplements are not as effective as food when it comes to getting the right amounts of vitamins and mineralsand some can actually be dangerous. "My motto is always 'food first,'" says Rachel Berman, R.D., Director of Nutrition for Calorie Count. "Foods found in nature are always more nutritious because our bodies are used to processing vitamins and minerals that come from natural sources." Here are five supplements you should never take after 50. Read onand to ensure your health and the health of others, don't miss these Sure Signs You've Already Had COVID.

A study from UC Davis showed that too much folic acid can aggravate complications related to vitamin B-12 deficiency, which could result in dangerous health conditions such as anemia and neurological damage. "There have been concerns that some people may be getting too much folic acid through a combination of sources, and we wanted to determine if there were reasons for those concerns," says Ralph Green, UC Davis professor of pathology and laboratory medicine. "Our results show that higher levels of folic acid could set in motion a metabolic imbalance that leads to more serious B-12 deficiency We do have to worry about folic-acid supplementation. The fact is that a lot of people are getting more of it than is good for them. If they happen to be B-12 deficient, more folic acid may actually harm them."

Hormone therapy such as HGH (human growth hormone) can be dangerous, experts warn. "In this entire field, I've only encountered one board-certified endocrinologist," says Thomas Perls, M.D., associate professor of medicine and geriatrics at Boston University School of Medicine. "It's outrageous that people think they can prescribe these toxic hormone soups There is no scientific proof of this. And studies show that increasing HGH levels with drugs predisposes people to heart disease, diabetes, and cancer."

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Anti-aging supplements have not been proven to work, experts warn, and most are not regulated by the FDA. "Many anti-aging doctors sell their own lines of nutraceuticals at very high prices," says Dr. Perls. "It's a profit margin that's better than what cocaine dealers get."

"We don't know if they could help, but they could be harmful," says Winifred K. Rossi, deputy director of the Division of Geriatrics and Gerontology at the National Institute on Aging.

Vitamin E is a common ingredient in brain health supplements, but too much can be dangerous.

"High doses of vitamin E supplements are associated with an increased risk of death," says dietitian Maxine Smith, RDN, LD, who recommends getting vitamin E from foods such as nuts, seeds, and dark green leafy vegetables.

Over-the-counter sexual enhancement products should be avoided, experts warn. "Products promising to enhance sexual performance have been promoted for over a century, dating back to the patent medicines of the 1800s; these products were characterized by wildly exaggerated claims and sold to the public by unscrupulous manufacturers, without evidence of safety or effectiveness," says W. Steven Pray, PhD, DPh. "Some manufacturers of impotence cures claim that their product is 'scientifically proven' to work. When a consumer sees the phrase 'clinical studies prove it works,' caution is in order, as these claims are often false. Furthermore, claims providing very high rates of success are often bogus." And to protect your life and the lives of others, don't visit any of these 35 Places You're Most Likely to Catch COVID.

Ferozan Mast

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Never Take This After Age 50, Warn Pharmacists Eat This Not That - Eat This, Not That

Jeffrey D. Gross, MD, a Neurosurgeon with SPINE and ReCELLebrate – Pro News Report

Get to know Neurosurgeon Dr. Jeffrey D. Gross, who serves patients throughout the States of California and Nevada and beyond.

(ProNewsReport Editorial):- New York City, New York Jun 8, 2022 (Issuewire.com)A board-certified and fellowship-trained neurosurgeon, Dr. Gross is the Owner of SPINE, and a regenerative medicine practice called ReCELLebrate, is seeing patients in Orange County, California, and in Henderson, Nevada, as well as remotely by computer video conference. In his practice, he offers specialized precision and concierge treatment options for patients with neck and/or back problems, as well as brain and head injuries. He provides a comprehensive approach to evaluating the pain generators of the spine and associated areas, and digs deeper to find the source of the problem when identifying the root issues of persistent pain and injuries. Dr. Gross employs regenerative medicine and other non-surgical options first and foremost. He is an internationally recognized expert in these fields.

As a leader in the fields of neurosurgery and stem cell medicine, he commonly treats other physicians and many patients with severe and complex spinal problems. He continually strives to find non-surgical treatments to conservatively assist with the resolution of the problems he identifies in each of his individual patients. In the event that non-surgical treatments are found to be inadequate, he approaches treatment options from the least invasive surgery first. Because of his methodology, he is frequently sought out to provide second opinions prior to many surgeries. He has authored numerous book chapters, and medical journal articles, and is in the process of completing his first book, Young Again, a practical how-to take anti-aging action for anyone. Dr. Gross has written and spoken internationally on regenerative medicine for the spine, and anti-aging. He has been awarded top doctor and best neurosurgeon awards.

A 1992 graduate of the George Washington University School of Medicine and Health Sciences, Dr. Gross went on to complete his internship and residency in neurosurgery at the University of California, Irvine in 1997. Finally, he completed his fellowship in spinal biomechanics and chief residency in neurological surgery at the University of New Mexico in 1999. He is a medical philanthropist and a perennial champion of patient needs over health insurance hassles and denials.

He has been recognized as a Fellow of the American Academy of Neurological Surgeons (FAANS), the doctor is board-certified in neurosurgery through the American Board of Neurological Surgery (ABNS), and is an active member of the Congress of Neurological Surgeons, and the North American Spine Society.

Neurosurgery is the medical specialty concerned with the prevention, diagnosis, surgical treatment, and rehabilitation of disorders that affect any portion of the nervous system including the brain, spinal cord, peripheral nerves, and extra-cranial cerebrovascular system. Neurosurgeons are doctors who diagnose and treat problems with the nervous system, often by performing surgery on the brain or spine. They treat strokes, tumors, certain types of birth defects, infections, and head or spinal cord injuries Dr. Gross applies conservative, non-surgical, and regenerative stem cell medicine options to first try to avoid surgery.

Learn More about Dr. Jeffrey D. Gross:Through his findatopdoc profile, https://www.findatopdoc.com/doctor/1363614-Jeffrey-Gross-Neurosurgeon, or through SPINE, https://ifixspines.com/about-dr-jeffrey-d-gross-md/, or ReCELLebrate, https://recellebrate.com/.

About FindaTopDoc.comFindaTopDoc is a digital health information company that helps connect patients with local physicians and specialists who accept your insurance. Our goal is to help guide you on your journey towards optimal health by providing you with the know-how to make informed decisions for you and your family.

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Jeffrey D. Gross, MD, a Neurosurgeon with SPINE and ReCELLebrate - Pro News Report

Radium was once cast as an elixir of youth. Are todays ideas any better? – Popular Science

From cities in the sky to robot butlers, futuristic visions fill the history ofPopSci. In theAre we there yet?column we check in on progress towards our most ambitious promises. Read the series and explore all our 150th anniversary coveragehere.

In 1923, Popular Science reported that people were drinking radium-infused water in an attempt to stay young. How far have we come to a real (and non-radioactive) cure for aging?

From the time Marie Curie and her husband Pierre discovered radium in 1898, it was quickly understood that the new element was no ordinary metal. When the Curies finally isolated pure radium from pitchblende (a mineral ore) in 1902, they determined that the substance was a million times more radioactive than uranium. At the time, uranium was already being used in medicine to X-ray bones and even treat cancer tumors, a procedure first attempted in 1899 by Tage Sjogren, a Swedish doctor. Coupled with radiums extraordinary radioactivity and unnatural blue glow, the mineral was soon touted as a cure for everything including cancer, blindness, and baldness, even though radioactivity had only been used to treat malignant tumors. As Popular Science reported in June 1923, it was even believed that a daily glassful of radium-infused water would restore youth and extend life, making it the latest in a long line of miraculous elixirs.

By May 1925 The New York Times was among the first to report cancer cases linked to radium. Two years later, five terminally ill women, who became known as the Radium Girls, sued the United States Radium Corporation where they had worked, hand-painting various objects with the companys poisonous pigment. As more evidence emerged of radiums carcinogenic effects, its cure-all reputation quickly faded, although it would take another half-century before the last of the luminous-paint processing plants was shut down. Radium is still used today in nuclear medicine to treat cancer patients, and in industrial radiography to X-ray building materials for structural defectsbut its baseless status as a life-extending elixir was short-lived.

And yet, radiums downfall did not end the true quest for immortality: Our yearning for eternal youth continues to inspire a staggering range of scientifically dubious products and services.

Since the early days of civilization, when Sumerians etched one of the first accounts of a mortal longing for eternal life in the Epic of Gilgamesh on cuneiform tablets, humans have sought a miracle cure to defy aging and defer death. Five thousand years ago in ancient Egypt, priests practiced corpse preservation so a persons spirit could live on in its mummified host. Fortunately, anti-aging biotech has advanced from mummification and medieval quests for the fountain of youth, philosophers stone, and holy grail, as well as the perverse practices of sipping metal-based elixirs, bathing in the blood of virgins, and even downing Radium-infused water in the early 20th century. But what hasnt changed is that the pursuit of eternal youth has largely been sponsored by humankinds wealthiest citizens, from Chinese emperors to Silicon Valley entrepreneurs.

Weve all long recognized that aging is the greatest risk factor for the overwhelming majority of chronic diseases, whether it be Alzheimers disease, cancer, osteoporosis, cardiovascular diseases, or diabetes, says Nathan LeBrasseur, co-director of The Paul F. Glenn Center for Biology of Aging Research at the Mayo Clinic in Minnesota. But weve really kind of said, well, theres nothing we can do about senescence [cellular aging], so lets move on to more prevalent risk factors that we think we can modify, like blood pressure or high lipids. In the last few decades, however, remarkable breakthroughs in aging research have kindled interest and opened the funding spigots. Fortunately, the latest efforts have been grounded in more established scienceand scientific methodsthan was available in radiums heyday.

In the late 19th century, just as scientists began zeroing in on germs with microscopes, evolutionary biologist August Weismann delivered a lecture on cellular aging, or senescence. The Duration of Life (1881) detailed his theory that cells had replication limits, which explained why the ability to heal diminished with age. It would take 80 years to confirm Weismanns theory. In 1961, biologists Leonard Hayflick and Paul Moorhead observed and documented the finite lifespan of human cells. Another three decades later, in 1993, Cynthia Kenyon, a geneticist and biochemistry professor at the University of California, San Francisco, discovered how a specific genetic mutation in worms could double their lifespans. Kenyons discovery gave new direction and hope to the search for eternal youth, and wealthy tech entrepreneurs were eager to fund the latest quest: figuring out how to halt aging at the cellular level. (Kenyon is now vice president of Calico Research Labs, an Alphabet subsidiary.)

Weve made such remarkable progress in understanding the fundamental biology of aging, says LeBrasseur. Were at a new era in science and medicine, of not just asking the question, what is it about aging that makes us at risk for all these conditions? But also is there something we can do about it? Can we intervene?

In modern aging research labs, like LeBrasseurs, the focus is to tease apart the molecular mechanisms of senescence and develop tools and techniques to identify and measure changes in cells. The ultimate goal is to discover how to halt or reverse the changes at a cellular level.

But the focus on the molecular mechanisms of aging is not new. In his 1940 book, Organisers and Genes, theoretical biologist Conrad Waddington offered a metaphor for a cells life cyclehow it grows from an embryonic state to something specific. In Waddingtons epigenetic landscape, a cell starts out in its unformed state at the top of a mountain with the potential to roll downhill in any direction. After encountering a series of forks, the cell lands in a valley, which represents the tissue it becomes, like a skin cell or a neuron. According to Waddington, epigenetics are the external mechanisms of inheritanceabove and beyond standard genetics, such as chemical or environmental factorsthat lead the cell to roll one way or another when it encounters a fork. Also according to Waddington, who first proposed the theory of epigenetics, once the cell lands in its valley, it will remain there until it diesso, once a skin cell, always a skin cell. Waddington viewed cellular aging as a one-way journey, which turns out to be not so accurate.

We know now that even cells of different types keep changing as they age, says Morgan Levine, who until recently led her own aging lab at the Yale School of Medicine, but is now a founding principal investigator at Altos Labs, a lavishly funded startup. The [Waddington] landscape keeps going. And the new exciting thing is reprogramming, which shows us that you can push the ball back the other way.

Researchers like Levine continue to discover new epigenetic mechanisms that can be used to not only determine a cells age (epigenetic or biological clock) but also challenge Waddingtons premise that a cells life is one way. Cellular reprogramming is an idea first attempted in the 1980s and later advanced by Nobel Prize recipient Shinya Yamanaka, who discovered how to revert mature, specialized cells back to their embryonic, or pluripotent, state, enabling them to start fresh and regrow, for instance, into new tissue like liver cells or teeth.

I like to think of the epigenome as the operating system of a cell, Levine explains. So more or less all the cells in your body have the same DNA or genome. But what makes the skin cell different from a brain cell is the epigenome. It tells a cell which part of the DNA it should use thats specific to it. In sum, all cells start out as embryonic or stem cells, but what determines a cells end state is the epigenome.

Theres been a ton of work done with cells in a dish, Levine adds, including taking skin cells from patients with Alzheimers disease, converting them back to stem cells, and then into neurons. For some cells, you dont always have to go back to the embryonic stem cell, you can just convert directly to a different cell type, Levine says. But she also notes that what works in a dish is vastly different from what works in living specimens. While scientists have experimented with reprogramming cells in vivo in lab animals with limited success, the ramifications are not well understood. The problem is when you push the cells back too far [in their life cycle], they dont know what theyre supposed to be, says Levine. And then they turn into all sorts of nasty things like teratoma tumors. Still, shes hopeful that many of the problems with reprogramming may be sorted out in the next decade. Levine doesnt envision people drinking cellular-reprogramming cocktails to stave off agingat least not in the foreseeable futurebut she does see early-adopter applications for high-risk patients who, lets say, can regrow their organs instead of requiring transplants.

While the quest for immortality is still funded largely by the richest of humans, it has morphed from the pursuit of mythical objects, miraculous elements, and mystical rituals to big business, raising billions to fund exploratory research. Besides Calico and Altos Labs (funded by Russian-born billionaire Yuri Milner and others), theres Life Biosciences, AgeX Therapeutics, Turn Biotechnologies, Unity Biotechnology, BioAge Labs, and many more, all founded in the last decade. While theres considerable hype for these experimental technologies, any actual products and services will have to be approved by regulatory agencies like the Food and Drug Administration, which did not exist when radium was being promoted as a cure-all in the US.

While were working on landing long-term moon shots like editing genomes with CRISPR and reprogramming epigenomes to halt or reverse aging, LeBrasseur sees near-term possibilities in repurposing existing drugs to prop up senescent cells. When a cell gets old and damaged, it has one of three choices: to succumb, in which case it gets flushed from the system; to repair itself because the damage is not so bad; or to stop replicating and hang around as a zombie cell. Not only do [zombie cells] not function properly, explains LeBrasseur, but they secrete a host of very toxic molecules known as senescence associated secretory phenotype, or SASP. Those toxic molecules trigger inflammation, the precursor to many diseases.

It turns out there are drugs, originally targeted at other diseases, that are already in anti-aging trials because theyve shown potential to impact cell biology at a fundamental level, effectively staving off senescence. Although rapamycin was originally designed to suppress the immune system in organ transplant patients, and metformin to assist diabetes patients, both have shown anti-aging promise. When you start looking at data from an epidemiological lens, you recognize that these individuals [like diabetes patients taking metformin] often have less cardiovascular disease, notes LeBrasseur. They also have lower incidence of cancer, and theres some evidence that they may even have lower incidence of Alzheimers disease. Even statins (for cardiovascular disease) and SGL2 inhibitors (another diabetes drug) are being explored for a possible role in anti-aging. Of course, senescence is not all bad. It plays an important role, for example, as a protective mechanism against the development of malignant tumorsso tampering with it could have its downsides. Biology is so smart that weve got to stay humble, right? says LeBrasseur.

Among other things, the Radium Girls taught us to avoid the hype and promise of new and unproven technologies before the pros and cons are well understood. Weve already waited millennia for a miracle elixir, making some horrific choices along the way, including drinking radioactive water as recently as a century ago. The 21st century offers its own share of anti-aging quackery, including unregulated cosmetics, questionable surgical procedures, and unproven dietary supplements. While we may be closer than weve ever been in human history to real solutions for the downsides of aging, there are still significant hurdles to overcome before we can reliably restore youth. It will take years or possibly decades of research, followed by extensive clinical trials, before todays anti-aging research pays dividendsand even then its not likely to come in the form of a cure-all cocktail capable of bestowing immortality. In the meantime, LeBrasseurs advice is simple for those who can afford it: You dont have to wait for a miracle cure. Lifestyle choices like physical activity, nutritional habits, and sleep play a powerful role on our trajectories of aging. You can be very proactive today about how well you age. Unfortunately, not everyone has the means to follow LeBrasseurs medical wisdom. But the wealthiest among usincluding those funding immortalitys questmost definitely do.

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Radium was once cast as an elixir of youth. Are todays ideas any better? - Popular Science