Bitcoin Founder Satoshi Nakamoto Believed To Have $10.9 Billion Worth Of BTC – International Business Times

KEY POINTS

A new research by analytics firm Whale Alert reveals that the miner known as "Patoshi",while mining during the early days of Bitcoin, is in possession of 1,125,150 BTC, worth $10.9 billion. Patoshi, who is believedto beBitcoin creator Satoshi Nakamoto, has also made the effort to protect the network from attacks during Bitcoins early days.

Patoshi is the name given by analyst Sergio Demian Lerner to the early Bitcoin miner who has a distinct pattern in themining activity. Lerner believes Patoshi is Satoshi based on a pattern left by using a modified version of Bitcoin Core, which Satoshi allegedly used.

The particular pattern could be found at the beginning of the network and also in the blocks that mined the Bitcoins sent to Hal Finney, the first person to received Bitcoins through the network. By connecting the two pieces of information together, Whale Alert deduced the identity of Patoshi.

Whale Alert also found out that Patoshi adjusted his mining speed between blocks to maintain the average time of 10 minutes. The analytics firm thought this was done to protect the network from a 51%attack, a malicious takeover of the network by bad actors. Also, Patoshi made sure he maintained 60%of the processing power while leaving enough blocks for other miners. The more miners joined the network, the more secure it was and the lesser the chance for a 51% attack to be successful. When Patoshi decided the network was strong enough, he reduced his blocks per 10 minutes so others have more chance of mining a block.

At some point, however, it became difficult to track Patoshis blocks so it was impossible to know if Patoshi (or Satoshi) had continued or stopped mining. Whale Alert said the node or computer (miner) used to mine the Patoshi blocks was turned off around May 2010. In total, 907 BTC was spent from the Bitcoins mined on the Patoshi blocks and 1,122,693 BTC was unspent.

Around the same time, Satoshi was active in the BitcoinTalk forum until Dec.12, 2010. Satoshi's last verified communication was an email to then-Bitcoin developer Gavin Andresen. I wish you wouldnt keep talking about me as a mysterious shadowy figure, the press just turns that into a pirate currency angle, Satoshi said.

Gold-colored Bitcoin coin on ground Photo: Andr Franois McKenzie on Unsplash

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Bitcoin Founder Satoshi Nakamoto Believed To Have $10.9 Billion Worth Of BTC - International Business Times

The Famous AI Turing Test Put In Reverse And Upside-Down, Plus Implications For Self-Driving Cars – Forbes

AI and the Turing Test, turned round and round.

How will we know when the world has arrived at AI?

To clarify, there are lots of claims these days about computers that embody AI, implying that the machine is the equivalent of human intelligence, but you need to be wary of those rather brash and outright disingenuous assertions.

The goal of those that develop AI consists of one day being able to have a computer-based system that can exhibit human intelligence, doing so in the widest and deepest of ways that human intelligence exists and showcases itself.

There is not any such AI as yet devised.

The confusion over this matter has gotten so out-of-hand that the field of AI has been forced into coming up with a new moniker to express the outsized revered goal of AI, proclaiming now that the goal is to arrive at Artificial General Intelligence (AGI).

This is being done in hopes of emphasizing to laymen and the public-at-large that the vaunted and desired AI would include common-sense reasoning and a slew of other intelligence-like capacities that humans have (for details about the notion of Strong AI versus Weak AI, along with Narrow AI too, see my explanation at this link here).

Since there is quite some muddling going on about what constitutes AI and what does not, you might wonder how we will ultimately be able to ascertain whether AI has been unequivocally attained.

We rightfully should insist on having something more than a mere provocateur proclamation and we ought to remain skeptical about anyone that holds forth an AI system that they declare is the real deal.

Looks alone would be insufficient to attest to the arrival.

There are plenty of parlor stunts in the AI bag-of-tricks that can readily fool many into believing that they are witnessing an AI of amazing human-like qualities (see my coverage of such trickery at this link here).

No, just taking someones word for AI having been accomplished or simply kicking the tires of the AI to feebly gauge its merits is insufficient and inarguably will not do.

There must be a better way.

Those within the AI field have tended to consider a type of test known as the Turing Test to be the gold standard for seeking to certify AI as being the venerated AI or semantically the AGI.

As named after its author, Alan Turing, the well-known mathematician and early pioneer in the computer sciences, the Turing Test was devised in 1950 and remains pertinent still today (heres a link to the original paper).

Parsimoniously, the Turing Test is relatively easy to describe and indubitably straightforward to envision (for my deeper analysis on this, see the link here).

Heres a quick rundown about the nature of the Turing Test.

Imagine that we had a human hidden behind a curtain, and a computer hidden behind a second curtain, such that you could not by sight alone discern what or who is residing behind the two curtains.

The human and the computer are considered contestants in a contest that will be used to try and figure out whether AI has been reached.

Some prefer to call them subjects rather than contestants, due to the notion that this is perhaps more of an experiment than it is a game show, but the point is that they are participants in a form of challenge or contest involving wits and intelligence.

No arm wrestling is involved, and nor any other physical acts.

The testing process is entirely about intellectual acumen.

A moderator serves as an interrogator (also referred to as a judge because of the designated deciding role in this matter) and proceeds to ask questions of the two participants that are hidden behind the curtains.

Based on the answers provided to the questions, the moderator will attempt to indicate which curtain hides the human and which curtain hides the computer. This is a crucial judging aspect. Simply stated, if the moderator is unable to distinguish between the two contestants as to which is the human and which is the computer, presumably the computer has sufficiently proven that it is the equivalent of human intelligence.

Turing originally coined this the imitation game since it involves the AI trying to imitate the intelligence of humans. Note that the AI does not necessarily have to be crafted in the same manner as humans, and thus there is no requirement that the AI has a brain or uses neurons and such. Thus, those devising AI are welcome to use Legos and duct tape if that will do the job to achieve the equivalence of human intelligence.

To successfully pass the Turing Test, the computer embodying AI will have had to answer the posed questions with the same semblance of intelligence as a human. An unsuccessful passing of the Turing Test would occur if the moderator was able to announce which curtain housed the computer, thus implying that there was some kind of telltale clue that gave away the AI.

Overall, this seems to be a rather helpful and effective way to ferret out AI that is the aspirational AGI versus AI that is something less so.

Of course, like most things in life, there are some potential gotchas and twists to this matter.

Imagine we have set up a stage with two curtains and a podium for the moderator. The contestants are completely hidden from view.

The moderator steps up to the podium and asks one of the contestants how to make a bean burrito, and then asks the other contestant how to make a bologna sandwich. Lets assume that the answers are apt and properly describe the effort involved in making a bean burrito and in making a bologna sandwich, respectively so.

The moderator decides to stop asking any further questions.

Voila, the moderator announces, the AI is indistinguishable from human intelligence and therefore this AI is declared forthwith as having reached the pinnacle of AI, the long sought after AGI.

Should we accept this decree?

I dont think so.

This highlights an important element of the Turing Test, namely that the moderator needs to ask a sufficient range and depth of questions that will help root out the embodiment of intelligence. When the questions are shallow or insufficient, any conclusion reached is spurious at best.

Please know too that there is not a specified set of questions that have been vetted and agreed upon as the right ones to be asked during a Turing Test. Sure, some researchers have tried to propose the types of questions that ought to be asked, but this is an ongoing debate and to some extent illuminates that we are still not even quite sure of what intelligence per se consists of (it is hard to identify metrics and measures for that which is relatively ill-defined and ontologically squishy).

Another issue exists about the contestants and their behavior.

For example, suppose the moderator asks each of the contestants whether they are human.

The human can presumably answer yes, doing so honestly. The AI could say that it is not a human, opting to be honest, but then this decidedly ruins the test and seemingly undermines the spirit of the Turing Test.

Perhaps the AI should lie and say that it is the human. There are ethicists though that would decry such a response and argue that we do not want AI to be a liar, therefore no AI should ever be allowed to lie.

Of course, the human might lie, and deny that they are the human in this contest. If we are seeking to make AI that is the equivalent of human intelligence, and if humans lie, which we all know that humans certainly do lie from time-to-time, shouldnt the AI also be allowed to lie?

Anyway, the point is that the contestants can either strive to aid the Turing Test or can try to undermine or distort the Turing Test, which some say is fine, and that it is up the moderator to figure out what to do.

Alls fair in love and war, as they say.

How tricky do we want the moderator to be?

Suppose the moderator asks each of the contestants to calculate the answer to a complex mathematical equation. The AI can speedily arrive at a precise answer of 8.27689459, while the human struggles to do the math by hand and come up with an incorrect answer of 9.

Aha, the moderator has fooled the AI into revealing itself, and likewise the human into revealing that they are a human, doing so by asking a question that the computer-based AI readily could answer and that a human would have a difficult time answering.

Believe it or not, for this very reason, AI researchers have proposed the introduction of what some describe as Artificial Stupidity (for detailed facets of this topic, see my coverage here). The idea is that the AI will purposely attempt to be stupid by sharing answers as though they were prepared by a human. In this instance, the AI might report that the answer is 8, thus the response is a lot like the one by the human.

You can imagine that having AI purposely try to make mistakes or falter (this is coined as the Dimwit ploy by AI, see my explanation at this link here), seems distasteful, disturbing, and not something that everyone necessarily agrees is a good thing.

We do allow for humans to make guffaws, but having AI that does so, especially when it knows better would seem like a dangerous and undesirable slippery slope.

The Reverse Turing Test Rears Its Head

Ive now described for you the overall semblance of the Turing Test.

Next, lets consider a variation that some like to call a Reverse Turing Test.

Heres how that works.

The human contestant decides they are going to pretend that they are the AI. As such, they will attempt to provide answers that are indistinguishable from the AIs type of answers.

Recall that the AI in the conventional Turing Test is trying to seem indistinguishable from a human. In the Reverse Turing Test, the human contestant is trying to reverse the notion and act as though they were the AI and therefore indistinguishable from the AI.

Well, that seems mildly interesting, but why would the human do this?

This might be done for fun, kind of laughs for people that enjoy developing AI systems. It could also be done as a challenge, trying to mimic or imitate an AI system, and betting whether you can do so successfully or not.

Another reason and one that seems to have more chops or merit consists of doing what is known as a Wizard of Oz.

When a programmer is developing software, they will sometimes pretend that they are the program and use a facade front-end or interface to have people interact with the budding system, though those users do not know that the programmer is watching their interaction and ready to interact too (doing so secretively from behind the screen and without revealing their presence).

Doing this type of development can reveal how the end-users are having difficulties using the software, and meanwhile, they remain within the flow of the software by the fact that the programmer intervened, quietly, to overcome any of the computer system deficiencies that might have disrupted the effort.

Perhaps this makes clear why it is often referred to as a Wizard of Oz, involving the human staying in-the-loop and secretly playing the role of Oz.

Getting back to the Reverse Turing Test, the human contestant might be pretending to be the AI to figure out where the AI is lacking, and thus be better able to enhance the AI and continue on the quest toward AGI.

In that manner, a Reverse Turing Test can be used for perhaps both fun and profit.

Turing Test Upside-Down And Right Side Up

Some believe that we might ultimately be headed toward what is sometimes called the Upside-Down Turing Test.

Yes, thats right, this is yet another variant.

In the Upside-Down Turing Test, replace the moderator with AI.

Say what?

This less discussed variant involves having AI be the judge or interrogator, rather than a human doing so. The AI asks questions of the two contestants, still consisting of an AI and a human, and then renders an opinion about which is which.

Your first concern might be that the AI seems to have two seats in this game, and as such, it is either cheating or simply a nonsensical arrangement. Those that postulate this variant are quick to point out that the original Turing Test has a human as a moderator and a human as a contestant, thus, why not allow the AI to do the same.

The instant retort is that humans are different from each other, while AI is presumably the same thing and not differentiable.

Thats where those interested in the Upside-Down Turing Test would say you are wrong in that assumption. They contend that we are going to have multitudes of AI, each of which will be its own differentiable instance, and be akin to how humans are each distinctive instances (in brief, the argument is that AI will be polylithic and heterogeneous, rather than monolithic or homogeneous).

The counterargument is that the AI is presumably going to be merely some kind of software and a machine, all of which can be readily combined into other software and machines, but that you cannot readily combine humans and their brains. We each have a brain intact within our skulls, and there are no known means to directly combine them or mesh them with others.

Anyway, this back-and-forth continues, each proffering a rejoinder, and it is not readily apparent that the Upside-Down variant can be readily discarded as a worthwhile possibility.

As you might imagine, there is an Upside-Down Turing Test and also an Upside-Down Reverse Turing Test, mirroring the aspect of the conventional Turing Test and its counterpart the Reverse Turing Test (some, by the way, do not like the use of Upside-Down and instead insist that this added variant is merely another offshoot of the Reverse Turing Test).

You might begrudgingly agree to let the AI be in two places at once, and have one AI as the interrogator and one as a contestant.

What good does that do anyway?

One thought is that it helps to potentially further showcase whether AI is intelligent, which might be evident as to the questioning and the nature of how the AI digests the answers being provided, illustrating the AIs capacity as the equivalent of a human judge or interrogator.

Thats the mundane or humdrum explanation.

Are you ready for the scary version?

It has to do with intelligence, as Ill describe next.

Some believe that AI will eventually exceed human intelligence, arriving at Artificial Super Intelligence (ASI).

The word super is not meant to imply superman or superwoman kinds of powers, and instead of that, the intelligence of the AI is beyond our human intelligence, though not necessarily able to leap tall buildings or move faster than a speeding bullet.

Nobody can say what this ASI or superintelligence might be able to think of, and perhaps we as humans are so limited in our intelligence that we cannot see beyond our limits. As such, the ASI might be intelligent in ways that we cannot foresee.

Thats why some are considering AI or AGI to potentially be an existential threat to humanity (this is something that for example Elon Musk has continued to evoke, see my coverage at this link here), and the ASI presumed to be even more so a potential menace.

If you are interested in this existential threat argument, as Ive pointed out repeatedly (see the link here), there are just as many ways to conjure that the AI or AGI or ASI will help mankind and aid us in flourishing as there are the doomsday scenarios of our being squashed like a bug. Also, there is a rising tide of interest in AI Ethics, fortunately, which might aid in coping with, avoiding, or mitigating the coming AI calamities (for more on AI Ethics, see my discussion at this link here).

That being said, it certainly makes sense to be prepared for the doom-and-gloom scenario, due to the rather obvious discomfort and sad result that would accrue going down that path. I presume that none of us want to be summarily crushed out of existence like some annoying and readily dispatched pests.

Returning to the Upside-Down Turing Test, it could be that an ASI would sit in the moderator's seat and be judging whether conventional AI has yet reached the aspirational level of AI that renders it able to pass the Turing Test and be considered indistinguishable from human intelligence.

Depending on how far down the rabbit hole you want to go on this, at some point the Turing Test might have two seats for the ASI, and one seat for AI. This means that the moderator would be an ASI, while there is conventional AI as a contestant and another ASI as the other contestant.

Notice that there is not a human involved at all.

Maybe we ought to call this the Takeover Turing Test.

No humans needed; no humans allowed.

Conclusion

It is unlikely that AI is going to be crafted simply for the sake of making AI, and instead, there will be a purpose-driven rationale for why humans opt to create AI.

One such purpose involves the desire to have self-driving cars.

A true self-driving car is one that has AI driving the car and there is no need for a human driver. The only role of a human would be as a passenger, but not at all as a driver.

A vexing question right now is what level or degree of AI is needed to achieve self-driving cars.

Some believe that until AI has arrived at the aspirational AGI, we will not have true self-driving cars. Indeed, those with such an opinion would likely say that the AI has to achieve sentience, perhaps doing so in a moment of switchover from automation into a spark of being that is called the moment of singularity (for more on this, see my analysis at this link here).

Hogwash, some counter, and insist that we can get AI that is not necessarily Turing Test worthy but that can nonetheless safely and properly drive cars.

To be clear, right now there is not any kind of AI self-driving car that approaches anything like AGI, and so for the moment, we are faced with trying to decide if plain vanilla AI can be sufficient to drive a car. Quick aside, for those interested in AI, some refer to any symbolic approach to AI as GOFAI or Good Old-Fashioned Artificial Intelligence, which is both endearing and to some degree a backhanded slight, all at the same time (see more at my explanation here).

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The Famous AI Turing Test Put In Reverse And Upside-Down, Plus Implications For Self-Driving Cars - Forbes

Pain Clinic in Indianapolis Has Changed Its Name to Unity Spine & Joint – North Indy – Press Release – Digital Journal

Unity Spine & Joint, a pain clinic with pain management doctors and holistic chiropractors, has announced that PSC Clinics North Indy has changed its name to Unity Spine & Joint - North Indy. This is because Unity Physician Services, the parent company of Unity Spine & Joint, had partnered with Pain Stop Clinic in North Indianapolis. PSC Clinics North Indy has a broad array of services and specialties not commonly found in typical pain management practices. This enables them to provide the patient with the correct diagnostic testing, medical procedures, chiropractic and physical medicine modalities. They are a One-Stop Shop for pain relief in North Indianapolis, Indiana along with locations in the Phoenix, Arizona Valley. With the change in name, PSC Clinics North Indy is now also part of Unity Spine & Joint.

Unity Spine & Joint provides a full-service concierge service committed to helping providers and their patients reduce stress, be happier, and live better lives. They focus on providing responsible pain management and pain relief. They have a wide range of services and specialties that are not usually found in conventional pain management practices. This allows them to offer patients the appropriate diagnostic testing, medical procedures, and physical exercise and chiropractic modalities.

Unity Spine & Joint offers a number of pain relief treatments. These include physical medicine modalities, epidurals, medial branch blocks, facet joint injections, radiofrequency neuroablation, pharmacological intervention, nerve blocks, and low dose steroid injections. They also offer treatment for pain due to injuries sustained from auto accidents and pain in the arms and legs, head and neck, and the back. They also offer male testosterone therapy in Indianapolis.

Dr. Thomas Morgan from Unity Spine & Joint says, Aging men can experience dramatic quality-of-life improvements from a program of optimized, individualized testosterone therapy supported by moderate exercise and sensible nutrition.

He continues, Testosterone replacement therapy alone can improve your energy and attitude. But along with a program of moderate exercise and good nutrition, testosterone replacement therapy can reverse the typical course of added weight, decreased performance and diminished drives. Exercise and proper nutrition are powerful complements to testosterone therapy and provide momentum in the patients efforts toward improved health and performance.

There are a number of signs of low testosterone. These include reduced energy, weight gain, loss of muscle mass, pain/ inflammation, poor recovery, depression, irritability, reduced libido, decreased memory, difficulty sleeping, and erectile changes. Male testosterone therapy, especially when complemented by proper nutrition and exercise, offers a number of benefits. These include enhanced vitality, increased libido, increased enjoyment of life, increased strength, enhanced mood, increased muscle size, improved sleep, reduced body fat, and improved motivation.

Meanwhile, trigger points develop when a muscle has been injured or overworked. This is a little knot of muscle that causes pain in that general area. They may also cause referred pain that is related to different areas of the body because the trigger point is sitting on or near a nerve. These can be treated by injections of safe low-dose steroid alternatives, including a local anesthetic.

A joint injection is for treating pain and/or inflammation in a joints space. A small needle is inserted through the skin and tissue with the injection points usually the shoulders, elbows, wrists, fingers, or knees.

They also offer chiropractic therapy as a non-surgical solution to back pain and other health conditions that may benefit from a balanced spine and nervous system. It is a safe and effective treatment for decreasing pain, inflammation, and damage to the musculoskeletal system. Conditions that may be treated by chiropractic therapy include upper back pain, lower back pain, shoulder pain, neck pain, knee pain, hip pain, sciatic pain, and bulging/ herniated disc.

https://www.youtube.com/watch?v=7fFztBAnr2k

Those who are looking for a pain clinic in Indianapolis may want to check out the Unity Spine & Joint website, or contact them on the telephone or through email. They are open from Monday to Thursday, from 8:00 am to 5:00 pm, and on Fridays from 8:00 am to 2:00 pm.

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For more information about Unity Spine & Joint, contact the company here:

Unity Spine & JointDr. Thomas Morgan602-603-4077tom@unitydoctors.com4765 S Lakeshore Dr, Tempe AZ 85282

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Pain Clinic in Indianapolis Has Changed Its Name to Unity Spine & Joint - North Indy - Press Release - Digital Journal

Seasteading 101: How to Build the Worlds First Floating …

In 2017, 40 percent of entrepreneurs were female, representing a 58 percent uptick in female-owned businesses from a decade prior. Fifty-six percent of college students are female, a complete reversal from fifty years prior, when 58 percent of men filled university halls. Yet in 2017, only 2.2 percent of venture capital (VC) money went to women-founded companies. Society has changed, yet the worlds of start-ups and venture capital are still predominantly run by white men.

Big Think was founded in 2007 by Victoria Montgomery Brown and Peter Hopkins. As with many start-ups, the fundraising process provides quite a story, one that Brown has now decided to tell. Her forthcoming book, Digital Goddess: The Unfiltered Lessons of a Female Entrepreneur (HarperCollins Leadership), reveals how this website came to beand how women can overcome barriers in a male-dominated business world.

Below are six lessons from Brown's chapter on raising capital when you have no money or product. Brown writes that there are essential qualities for starting a business that help you navigate the terrain, such as a having a strong vision and maintaining unflinching tenacity. While some of these came naturally to Brown, others were hard-fought lessons that changed her for the better. The chapterand the bookis a reminder that with perseverance and dedication to learning, anything is possible.

Use whatever will get you in the door

The greatest challenge every start-up faces is "first money in." Many investors are willing to back a good idea only when someone else has already committedand they like to know who that someone else is.

In some ways, being a female founder has its advantages. As Brown writes, a Boston Consulting Group study shows that female-run start-ups outperform male-run start-ups, generating 78 cents in revenue per dollar invested compared to men at 31 cents. That's solid data, but you still need to get in the door.

Brown leaned heavily on her master's degree from Harvard Business School. This helped tremendously for her first investor meeting with Founder Collective co-founder David Frankel. He was enthusiastic, but he wanted to know who else was interested. Brown turned to former Harvard University president, Larry Summers. His buy-in increased Frankel's interest; he became the lead investor.

Meeting with such heavyweights is no easy matter for entrepreneurs with no product or history in founding a company. As Brown writes, "Study after study confirms that people tend to equate confidence with competence." Presenting Big Think confidently made the impression needed to secure funding.

With two investors in, landing Nantucket Nectars founder Tom Scott and billionaire entrepreneur Peter Thiel was not as challenging as one might assume. Brown writes, "Getting the first investor feels impossible, but if you can pull it off, getting the second is sometimes surprisingly easy."

Quit your day job

This is one of the hardest aspects of being an entrepreneur. Not only do founders not have the capital needed to launch their company, they sometimes work for years without paying themselves. If investors are going to put money into your project, they have to know you're serious about success.

"People don't like to fund things if the entrepreneur and CEO don't have their entire skin in the game. You better have something big to lose, or how are people going to believe you are all in?"

With no income or savings, Brown quit her day job in order to devote her every waking hour to Big Think. Self-imposed deadlines made sure she hit her targets. Founding a company isn't comfortable; waiting for relief will only distract you from the work that needs to get done.

"If you truly want to start somethingwhatever it may bewaiting won't helpput yourself in a position where you must do it."

Three months after quitting her day job, money showed up in Big Think's bank account.

Build momentum

If you're trying to convince investors to believe in youand it is you that they're investing in, more than your productshow them traction, even when you don't have it. Go out and make it happen.

"Our investors needed to be intrigued by the idea and see its potential to succeed and to scale, but they also needed to see that I was actually in a place of discomfort if it didn't work out."

Securing funding before showing a minimal viable product (MVP) is no easy task. Brown knew that she had to show something. Big Think started as a video platform; she needed experts to appear on video. Through their networks, Brown and Hopkins contacted Richard Branson, Moby, the Buddhist scholar Robert Thurman, and famed architect Lee Mindel. They wanted them to be anchors.

Convincing high-profile business leaders, artists, and academics to partake in a new project is as daunting as landing VCs. When these figures inevitably asked about precedent for such an initiative, Brown turned a potential negative into a positive. "No one. We are reaching out to a very select, initial group of experts to kick-start it."

Making people feel critical to a project's success is a powerful way to get their endorsement, Brown writes. More importantly, it worked. A risky play between content generators and financial backers worked out. Big Think had momentum.

Do your research

As mentioned, investors are often more interested you than your product. As Brown writes, fundraising is "about creating a situation where investors get a real glimpse of who you are and why they should invest in you."

It's not a one-way street. You should also be interested in them.

"Be truly interested in the person you are meeting or don't bother meeting."

Brown advises looking beyond LinkedIn profiles and superficial bullet points. Investigate their interests, such as their passions and philanthropic pursuits. Understand why they might be interested in your venture and where it intersects with their business. Discuss topics outside of the investment opportunity. Engage them as people, not bank accounts.

"Helping others feel attractive and specialnot in a sexual way but in a human wayhelps them see you as a more attractive person, too. But you have to mean it."

Learn to say yes

The discomfort of being a founder includes stretching your boundaries. PayPal famously iterated numerous times before finding success. Flexibility is key if you want to survive. Sometimes that means admitting your limitations.

"Here's something major that HBS [Harvard Business School] taught me. You don't need to know how to do things, you need to know how to ask people to do things for you."

Finding the right people is one aspect of saying yes. By admitting your limitations, you say yes to help. But there's also saying yes to projects you're not entirely capable of pulling off.

After scoring a sponsorship with Pfizer, the second Big Think project was with MSNBC. The media company had a deal to provide expert-driven content with GE and SAP. They just didn't have a team to produce it. Being nimble, Big Think could turn it around quickly.

"Smaller companies with greater agility can take advantage of this situation if they just have the courage to step up and offer."

Instead of focusing on the negatives, such as not having a website or even equipment, Brown and Hopkins saw the opportunity. They said yes, and completed the project without a hitch, because they had the foresight to say yes.

Learn to say no

Not everything demands a yes, however. Discernment matters in the frenetic world of start-ups.

There are investors, there are people that connect you with investors, and there are charlatans. As the latter often suck up oxygen in any room they enter, it's easy to confuse bluster with their capabilities.

And so we meet "Jake," who in the early days of Big Think promised a lot, demanded more, and delivered nothing.

"He hadn't brought us any investors, he hadn't booked any experts, he hadn't helped us put together the deck, so what were we doing spending time with him? He felt sort of sleazy, like a smooth talker but not a doer."

Brown told Jake he was not getting equity without deliverables during their final meeting. This news did not go over well. Jake yelled and stormed out. Such momentary discomfort is a low price for not giving up even a piece of your business. Calling our charlatans demands that you say no. Thankfully, for the future of Big Think, one bad evening paid off in the long run.

Credit: Harper Collins

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Stay in touch with Derek on Twitter, Facebook and Substack. His next book is "Hero's Dose: The Case For Psychedelics in Ritual and Therapy."

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Seasteading 101: How to Build the Worlds First Floating ...

Psychedelics Make an Impression at Prohibition Partners LIVE | INN – Investing News Network

Curious investors were able to hear firsthand about the burgeoning psychedelics industry during the first Prohibition Partners LIVE event.

At the inaugural Prohibition Partners LIVE event, psychedelic drugs made a big splash.

Prohibition Partners is a research group that publishes reports on the latest developments in the cannabis industry. And while cannabis dominated the online forum, the business potential of psychedelics created conversations around this new space.

Adele Byrne, senior analyst with Prohibition Partners, kicked off the discussion around psychedelics by confirming the groups interest in the market with upcoming studies dedicated exclusively to the space.

Those will follow the groups initial March report examining the psychedelics industry, and Byrne said the team will continue to work on their market analysis for the sector.

The talks at the event included some of the established early leaders in the psychedelics market one of the biggest guests was Bruce Linton, former CEO of Canopy Growth (NYSE:CGC,TSX:WEED). He is now an advisor for Mind Medicine (MindMed) (NEO:MMED) and an investor in the psychedelics sector.

Linton has been a vocal supporter of the psychedelic drug industry, and is a larger figure commanding attention from investors given his role in the augmentation of the Canadian cannabis public markets.

Its always an allocation game, and I think being an investor in the market right now is a very good idea I think that its a good time to be an investor, but its not a good time to put all your investments in today, you need to be able to follow up with some, Linton said.

The ex-cannabis executive said hes interested in the psychedelics industry given its potential to provide alternative treatments for health issues that arent being met with appropriate relief.

One of the most unique organizations in the psychedelics industry is the Multidisciplinary Association for Psychedelic Studies (MAPS), a non-profit group that is responsible for putting together one of the most advanced studies in the entire sector.

Rick Doblin, founder and executive director of MAPS, explained the US Food and Drug Administration is open to engaging with the psychedelic drug maker industry given the medical potential these drugs have.

Doblin said the federal agency is willing to put science over politics when it comes to psychedelics, which is evidenced by the medical authoritys engagement with clinical studies.

JR Rahn, founder and CEO of MindMed, spoke at length with Stephen Murphy, group managing director with Prohibition Partners, about his involvement with the industry and the transition process he underwent originally coming from a tech investing background.

As one of the first big debuts in the capital markets, MindMed launched on the NEO Exchange in March, and Rahn pointed to the key benefits that going public has brought to his company.

When asked about the path for the adoption of psychedelic medicines once trials are successful, Rahn said that theres a long educational process ahead for both patients and doctors to combat the stigma associated with psychedelic drugs.

In a panel conversation, Doblin explained that it will be important to train and prepare medical workers so that they are ready for psychedelic drug demand.

Kevin OLeary, a Canadian investor and a judge on the business show Shark Tank, signed up as an early stage backer of MindMed and has pointed to the medical-only approach the company is taking as the key reason it obtained his money.

The decision to go public was motivated by MindMeds plan to build out a robust portfolio of clinical trials investigating the medical benefits of psychedelic drugs, Rahn said.

Going public, to me, was not even a question, the MindMed executive said. We needed to do it, we needed to build a platform that could develop these medicines and get them to patients.

As part of the conversation around public listings, Champignon Brands (CSE:SHRM,OTCQB:SHRMF) CEO Dr. Roger McIntyre said investors need to be ready for a rush of company pitches and available deals. He warned there will be shady players attempting to pass off as experts on the industry, and investors need to be aware not to fall for just any opportunity.

Market participants often point to the medical benefits of psychedelic drugs as a top reason why supporting this industry will be valuable. But for one executive its also a personal effort.

Rahn was candid about the path that led him to the industry during a panel at the online event. He told the audience about his own struggles with addiction and mental health and how these challenges were the foundation that eventually took him to launch MindMed.

There needed to be a company that could take this broader approach to how we look at mental health and not just look at a single mental illness like depression or anxiety as a one-off.

How do we look at creating a new paradigm and a new approach to how we deal with these issues? Thats really what motivates me, looking at the interconnectedness of mental health solutions and how we get those and deliver those to the world.

Dont forget to follow@INN_LifeSciencefor real-time updates!

Securities Disclosure: I, Bryan Mc Govern, hold no direct investment interest in any company mentioned in this article.

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Psychedelics Make an Impression at Prohibition Partners LIVE | INN - Investing News Network

Psychedelic Therapists Petition Government For Permission To Dose Themselves In Order To Better Treat Patients – Marijuana Moment

As a group of terminally ill patients in Canada awaits word from the minister of health on whether they can legally access psychedelic mushrooms for end-of-life care, their team of clinicians has tacked on an additional request: The therapists want to be able to dose themselves, too.

The group behind the request, Victoria, B.C.based TheraPsil, a nonprofit that aims to expand access to psilocybin-based psychotherapy in Canada, says the additional step of providing safe access for therapists will ensure they gain firsthand experience into the psilocybins effects and its applications to psychotherapy.

The fundamental reason to expose therapists to their own experiences with psychedelics is that, unless you have visited these realms, you are unlikely to understand their importance.

Part of ensuring a very high-quality psychedelic treatment for patients is to ensure high-quality training for therapists, Spencer Hawkswell, TheraPsils executive director, told Marijuana Moment in an interview. Its greatly beneficial if therapists have had psychedelic therapy themselves.

Few people, he offered by analogy, would advise going to a sex therapist whos never had sex before.

TheraPsil, founded by clinical psychologist and psychotherapist Bruce Tobin, has been fighting for expanded access to psilocybin end-of-life care for years. In 2017, the group first filed a petition to exempt patients with certain terminal conditions from Canadas ban on psilocybin. It was reportedly the first time a therapist had asked the Canadian government for such an exemption.

It wasnt until this past January that TheraPsil finally heard back, Hawkswell said. After three years of back-and-forth, they got back to us and said, Were going to be rejecting this application. The agency said there was no obvious medical necessity for the psychedelics.

TheraPsil was undaunted. They say theres no necessity, Hawkswell said. Maybe its because they havent met that person yet.

In April, the group helped four more people with terminal illnesses file petitions with Health Canada and Health Minister Patty Hajdu seeking exemptions that will allow them to access psilocybin. In an interview with Marijuana Moment, Hawkswell said patients had gone months so far without a word from Hajdu, who with a stroke of a pen could allow the patients to access the drug.

What we are working on right now is ramping up our messaging, Hawkswell said. We are going to try everything we can to get to the minister to make sure she sees these patients and responds to them.

Efforts to allow TheraPsils clinicians to use psilocybin themselves are more recent. Dr. Sean OSullivan, an emergency room physician and psychotherapist who serves on TheraPsils board of directors, said the exemptions are necessary so that therapists can be better trained and more familiar with how psychedelics work in a therapeutic setting.

The fundamental reason to expose therapists to their own experiences with psychedelics is that, unless you have visited these realms, you are unlikely to understand their importance, OSullivan told Marijuana Moment. The point is to allow therapists to understand the field theyre plowing in.

Therapists need to be alert and able to recognize how psychedelic experiences manifest themselves in therapy, OSullivan said. Patients might bring up material having to do with their own birth, a traumatic experience or interactions with otherworldly beings. If youre not attuned to this possibility, not aware of this possibility, then its just going to slide by you, he said.

Its a bit like describing Beethovens Fifth, OSullivan added. You can describe it all you like, but at some point you have to play the music.

As psychedelic therapy is more widely sought by patients, OSullivan said, demand for qualified therapists is likely to go up. We are expecting that as we get more permission for patients to access psilocybin at the end of life, he said, that there will be an increase in demand for therapists that have had that psychedelic experience.

Public opinion in Canada generally supports allowing access to psilocybin therapy for the terminally ill, TheraPsil says. A poll released by the group last month found that 59 percent of Canadians support legal access. Including respondents who said they were ambivalent, TheraPsil said, acceptance increased to 78 percent.

Whats unreasonable is the political decision to deny patients access to psilocybin, Hawkswell argued. Its not a scientific one, its not a democratic one. Its political.

Patients facing their imminent death often experience feelings and fears that psychedelics can help to ease, he said. Among them are demoralization, anxiety and depression. Existing treatment includes pharmaceuticals, talk therapy and occasionally inpatient treatment.

Psychedelics play a role in treatment by inducing what Hawkswell and others refer to as a mystical experiencea collection of psychoactive and sometimes spiritual events that accompany a psychedelic journey. The experience can reorient a persons way of thinking, dissolving barriers between an individual and the world around them.For end-of-life patients, he explained, it can help them embrace that death is naturaljust as natural as being born.

Practitioners note that psychedelic therapy doesnt work the same way as many other pharmaceutical drugs, such as antidepressants or even medical marijuana. Patients usually take those substances under their own supervision and allow them to work in the background. With therapeutic use of psilocybin and other psychedelics, patients typically take the drug and undergo guided psychotherapy. Psychedelics unusual, sometimes disorienting effects are believed to allow patients to better approach and engage obstacles, then emerge with a fresh perspective.

Another psychedelic therapy group, Field Trip, which uses ketamine in therapy, describes the treatment on their website as a way to press reset on your mental health.

The emerging promise of psychedelics in recent years have caught the attention of academics, public policy reformers and even the U.S. government. Last month, the University of North Carolina (UNC) announced a $27 million project funded by the department of defense to research and develop psychedelics-inspired drugs.

That projects researchers seem to believe they can separate psychedelics from what they describe as disorienting side effects, despite what Hawkswell and others say about the importance of a mystical experience.

Although drugs like ketamine and potentially psilocybin have rapid antidepressant actions, their hallucinogenic, addictive, and disorienting side effects make their clinical use limited, said Bryan L. Roth, a professor of pharmacology at UNC School of Medicine and the research teams leader. The government partnership, UNC said, aims to create new medications to effectively and rapidly treat depression, anxiety, and substance abuse without major side effects.

In September of last year, Johns Hopkins University announced the launch of the nations first-ever psychedelic research center, a $17-million project to study the use of psychedelics to treat conditions such as opioid use disorder, Alzheimers disease, depression, anxiety and post-traumatic stress disorder.

Meanwhile, activists in the United States have advocated for state- and local-level reforms to research, decriminalize and in some cases even legalize psychedelics themselves.

At the municipal level, Denver became the first U.S. city to enact such a reform, with voters in May 2019 approving a measure to effectively decriminalize possession of psilocybin mushrooms. Soon after, officials in Oakland, California, decriminalized possession of all plant- and fungi-based psychedelics. In January of this year, Oakland activists unveiled plans to allow go further and legalize the commercial sale of natural entheogenic substances. That same month in nearby Santa Cruz, the City Council effectively decriminalized psychedelics by voting to make the enforcement of laws against them among the citys lowest enforcement priorities.

Reformers are now pushing for similar changes in other jurisdictions. In Washington, D.C. this month, Decriminalize Nature D.C. submitted signatures to qualify a measure for Novembers ballot that would decriminalize all natural psychedelic drugs, including psilocybin, ayahuasca and ibogaine.

Other reform efforts are ongoing in Oregon, where voters later this year will decide whether to legalize psilocybin therapythe very therapy TheraPsils patients are pushing Canadian Health Minister Hajdu to allow. Oregon voters will also see a separate measure to decriminalize the possession of all drugs and expand access to treatment for problem use on their November ballot.

Lawmakers in Hawaii earlier this year approved a plan to study psilocybin mushrooms medical applications with the goal of eventually legalizing access.

In Canada, for now, psilocybin remains illegal. Hawkswell of TheraPsil, however, believes a constellation of other national policiesincluding medical marijuana, safe injection sites, and physician-assisted dyingsupport extending psilocybin access to patients in palliative care. And Canada already permits certain religious groups to use ayahuasca as religious sacrament, Hawkswell noted.

At this point psilocybin is a reasonable medical choice for these individuals, he told Marijuana Moment. This is about the minister being compassionate and using her ministerial abilities to help give patients access to something thats going to help them.

Patients waiting to hear back from Hajdus office, he said, dont have time to wait for lengthy, bureaucratic processes. Were not just going to keep waiting, he told Marijuana Moment. We do have a legal team prepared, but thats all Ill say.

Psychedelics Decrim Activists Mark First Anniversary Of Denvers Historic Psilocybin Mushroom Vote

Photo courtesy of Wikimedia/Workman

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Psychedelic Therapists Petition Government For Permission To Dose Themselves In Order To Better Treat Patients - Marijuana Moment

MagicMed Industries unveils C$1.5 million offering to expand its molecular psychedelic derivatives portfolio – Proactive Investors USA & Canada

MagicMeds Psybrary is a molecular derivatives library designed to be a key platform for the psychedelics industry to develop new patented products

said Monday it is planning to raise up to C$1.5 million to fund development of its portfolio of psychedelic derivative molecules.

The private company is working with Mackie Research Capital Corporation in the offering, which will consist of up to 6 million shares priced at C$0.25 each.

MagicMeds Psybrary is a molecular derivatives library designed to be a key platform for the psychedelics industry to develop new patented products.

The Psybrary will initially focus on psilocybin, but MagicMed expects to expand its scope to other psychedelics like MDMA, ketamine, Ibogaine, Mescaline, and Ayahuasca on an opportunistic basis. MagicMeds approach is to partner with pharmaceutical and other companies who can use thePsybrary as a building block to develop new patented products.

Under the term sheet, MagicMed will pay Mackie a cash commission equal to 8% of the aggregate gross proceeds of the offering in addition to a work fee and certain expenses.

A portion of the proceeds will also be used to expand MagicMeds scientific team, according to a statement, with additional funds earmarked for working capital and general corporate purposes.

The Calgary-based company recently filed a provisional patent application with the US Patent and Trademark Office (USPTO) related to the composition of matter, drug formation and the process of preparation for novel psilocybin derivatives, the first in a series of applications that together are designed to protect the Psybrary.

The offering is expected to close by August 14.

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MagicMed Industries unveils C$1.5 million offering to expand its molecular psychedelic derivatives portfolio - Proactive Investors USA & Canada

Profound psychedelic journeys brought peace to this Holocaust survivor – The Jewish News of Northern California

After his father disappeared to a forced labor camp in 1942, when George Sarlo was just 4 years old, it left a traumatic wound that would not heal for the next 70 years.

Then, when he was in his 70s, Sarlo had a life-changing experience. After ingesting a psychedelic native plant in a Mexican fishing village, Sarlo says he had an encounter with his dead father, who finally provided an answer to the question that had plagued his son for so many years: why hed left without saying goodbye.

That experience eight years ago has today made Sarlo, a successful San Francisco venture capitalist and philanthropist, an unlikely advocate for the use of psychedelic drugs to treat trauma, addiction, and the fear and anxiety that can accompany a diagnosis of terminal illness.

Sarlo, 82, shared his story last November at Congregation Emanu-El, explaining how his father leaving without saying goodbye had haunted him for 70 years nearly his entire life. Many of those listening were brought to tears.

Born in 1938 in Budapest, Sarlo was one of two children; his sister was seven years older. When the Hungarian government began passing anti-Jewish laws, Sarlos father lost his job as a clerk in a textile mill. Friends allowed him to buy remnants of fabric from the mill, and he and Sarlos mother, a talented seamstress, began sewing womens lingerie that his father would sell to dealers. They earned a decent living, until his father had to report for deportation to a labor camp. He left early one morning and never returned.

For the next three years the family moved around, living in fear and dread that the Nazis could deport them something that happened to their entire extended family, none of whom survived.

To make sure the same did not happen to her small family, Sarlos sister risked her life, sneaking out of the house to the Spanish Consulate, where she obtained lifesaving documents. Issued Spanish passports and papers, they spent the last three months of the war in a Budapest apartment with some two dozen others under the official protection of the Spanish government. Sarlo calls his sister the hero of the family.

When the war ended, Sarlo remembers a box arriving with warm clothing, Hersheys chocolate and chewing gum. It came from the Joint Distribution Committee.

My mother could not believe that somebody who didnt even know us sent us all this, said Sarlo. The idea of philanthropy was never explained to us. Being the beneficiary of such philanthropy at a pivotal point in his life would have great influence years later, when he was in the position to give back himself.

After liberation, Sarlos family stayed in Hungary and Sarlo entered the Technical University of Budapest in 1956, the year of the short-lived Hungarian revolution against Soviet control. Sarlo took part in the conflict, putting himself and his family in danger. His mother advised him to flee the country with his sister, his sisters husband and their 2-year-old son. She had remarried another survivor and they would stay in Hungary.

Its the bravest thing Ive ever heard. She said go, he said.

Sarlo carried his 2-year-old nephew during much of the escape. His backpack and a scarf from his mother that he wore while sneaking through a minefield and around electric-charged fences are now in an exhibit on refugees at the Smithsonian Museum.

They made it to Vienna, where they hired someone to smuggle Sarlos mother and husband out of Hungary, and eventually the whole family made it to America, where they were received by the Hebrew Immigrant Aid Society. Sarlo was 18, and the very next day he was working as a draftsman at an engineering firm.

Sarlos trajectory is a real immigrant success story. He attended the University of Arizona on a full scholarship and then went to Harvard Business School. He made his first million dollars within three years, working on Wall Street. He was a founder of the first venture capital firm investing in Silicon Valley and in 1973 founded his own firm, Walden Venture Capital.

It was good timing. My whole life was good timing, he said.

His first foray into philanthropy was with the International Refugee Committee, as Sarlo identified strongly with the plight of refugees, having been one himself. He also remembered the JDC box his family received in Hungary, and he eventually joined its board as well.

There are some difficult times coming, and Im not even sure that the species can survive without some change.

For many years Sarlo remained distant from his Judaism, but the connections began to build.

In the early 1990s, he accepted an invitation from local philanthropist Warren Hellman to join a Torah study group.

In 1992, he founded the George Sarlo Foundation and asked Phyllis Cook, then endowment director of the Jewish Community Endowment Fund at the S.F.-based Jewish Community Federation, to sit on his board. In time, she asked him to start a fund with the Federation.

The George Sarlo Foundation primarily funds mental health initiatives, with a major focus on addiction and early childhood trauma. Another focus, on psychedelics, brought Sarlo some notoriety after he was featured in an article in the New York Times last fall talking about funding research of psilocybin and MDMA. Given his own experiences, he has come to believe that even one guided experience with psychedelics as an adult can heal trauma or PTSD.

It was that 2012 trip to Mexico that convinced him of the healing power of psychedelics. At the recommendation of a fellow Hungarian Holocaust survivor and therapist friend, Sarlo went there specifically to take ayahuasca, a plant-medicine commonly used for rituals and healing by Indigenous people in Peru and other South American countries.

It was not a decision he made easily You want me to go where and do what? was his first response. But his friend, who had been using psychedelic therapy to treat addiction and trauma, made a persuasive argument.

In the second of two journeys with the substance, which is taken in a sacred ceremony led by a shaman, Sarlo says he had a conversation with his long-dead father, who told him that the reason he didnt say goodbye was because he thought he was clever enough to get out of any situation, and that hed return home by the time his son woke up.

Its a simple explanation and it fit, said Sarlo. Slowly, the low-grade depression I had experienced for most of my life lifted and never came back. And I decided I wanted to help give this incredible gift to as many people as I can manage.

Sarlo credits psychedelics with more than curing his depression. They also played a role in bringing him back to his Judaism.

During another psychedelic exploration, this time on psilocybin mushrooms, he had what he describes as a confrontation with God. In this particular vision, he saw God as male (though hes seen her as female too). God asked Sarlo why he had turned away, and Sarlo pointed to the Holocaust and the loss of his extended family.

The greatest gift I gave to humanity is free will, he says God told him. But then along comes Hitler. What was I supposed to do? Drown him? What about the runaway car about to hit a child? Am I supposed to save them all? You cant have it both ways.

Now thats an explanation I had heard before, but it didnt register, Sarlo said. This time, it registered.

Sarlo married and divorced twice and had two daughters. Neither wife was Jewish; he believes he subconsciously chose to marry non-Jewish women so his children wouldnt be Jewish and therefore would be safe though of course in the Holocaust that wouldnt have mattered.

In the end, both of his daughters married Jewish men. Two of his grandchildren had bnai mitzvahs and the third had a Jewish rite-of-passage ceremony.

Its hilarious, because it shows God has a sense of humor, is how Sarlo explains it.

George Sarlo had experienced this big healing within himself, a tikkun, said Rabbi Sydney Mintz, who moderated the conversation last fall at Emanu-El. He could have just done this and thought Its my own thing and Im healed, and that would have been acceptable, but he wants to share this with people; its transformed him into a teacher.

Sarlo has been working on a book to be published this summer with MAPS, the Santa Cruz-based Multidisciplinary Association for Psychedelic Studies, but the pandemic and the presidency of Donald Trump has made him feel a level of fear he had hoped never to feel again, he said. Hes now revising the original manuscript.

There are some difficult times coming, he said, and Im not even sure that the species can survive without some change.

But he seems to have found peace within himself. I think that because of my experiences, both in Judaism and with psychedelics, Im a much better father, he said. Im a much better grandfather and better friend. And Im better to myself.

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Profound psychedelic journeys brought peace to this Holocaust survivor - The Jewish News of Northern California

Mesenchymal Stem Cells Market Market Will Witness Substantial Growth in the Upcoming Years – 3rd Watch News

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Mesenchymal Stem Cells Market Market Will Witness Substantial Growth in the Upcoming Years - 3rd Watch News

In Remission for 10 Years: Long-term Data on CAR-T Therapy – Medscape

When a patient with cancer hears there isn't much left that doctors can do, it always stays fresh in the mind.

Doug Olson was first diagnosed with chronic lymphocytic leukemia (CLL) over 20 years ago, in 1996. For several years, his doctors used the watch-and-wait approach. But then his cancer progressed and needed treatment. By 2010, it had mutated so much that it no longer responded to standard therapy.

He was rapidly running out of options. Back then, the only treatment left was a bone marrow transplant. Without one, his doctors said, he would have 1 or 2 years left to live.

"I was really trying to avoid a bone marrow transplant. You're playing your last card if that doesn't work. It's a pretty rough procedure," Olson told Medscape Medical News.

Looking back, Olson counts himself as lucky for being in the right place, at the right time, with the right doctor. His oncologist was David Porter, MD, the principal investigator on a trial at the University of Pennsylvania that was investigating a brand new approach to treating cancer: chimeric antigen receptor (CAR) T-cell therapy.

CAR T-cell therapy uses a patient's own T cells engineered to express a receptor that targets proteins on cancer cells. CAR T cells are considered "living drugs" because they expand inside the body and stick around for years maybe for a lifetime to fight the cancer if it tries to come back.

"I was certainly intrigued by the approach. It had worked in mice, and it was the sort of thing that looked like it would work," Olson recalled.

Science is not a foreign language to Olson. He holds a PhD in medicinal chemistry, spent most of his career in the in vitro diagnostics industry, and currently acts as chief executive officer of Buhlmann Diagnostics Corp.

So he read the clinical protocol for the first in-human trial of CAR T cells and agreed to become patient number two.

Olson's T cells were harvested, engineered to attack the CD19 antigen found on malignant and normal B lymphocytes, and then were expanded into millions in the lab. After undergoing preconditioning with chemotherapy to minimize rejection and boost the CAR T cells' expansion inside the body, he received several infusions of the new therapy over the course of 3 days.

Nothing really happened for 2 weeks. Then he developed severe flu-like symptoms so bad that he was hospitalized.

Ironically, getting sick was a sign that the CAR T cells were working. Olson was experiencing one of the main short-term effects of CAR T-cell therapy: cytokine release syndrome. Symptoms include extremely high fevers and dangerous drops in blood pressure that can potentially cause end-organ damage.

In the early trials of these products, some patients experienced such a severe reaction that they needed intensive care, and some died. With increasing clinical experience, doctors have learned to control the reaction with the use of steroids and interleukein-6 inhibitors such as tocilizumab (Actemra).

Fortunately for Olson, the reaction passed, and he was eventually discharged.

Then the "aha moment" happened. Four weeks after receiving the CAR T cells, Olson found out that he was cancer free.

"It still gives me shivers," he said. "Dr Porter said, 'Your bone marrow's completely free. We just can't find a cancer cell anywhere.' "

The remission has lasted, and it is now 10 years later.

Long-term data have been accumulating for these novel therapies since Olson's treatment in 2010. This is particularly important for CAR T-cell therapy, because of its longevity. Because these are living cells and are expected to persist in the body for years, there is great interest in longer-term data, especially the risks for toxicity.

The FDA requires clinical follow-up for at least 15 years for patients treated with CAR T-cell therapy or any other genetically modified cells.

So far, most of the experience with CAR T cells comes from anti-CD19-directed therapy, which has shown "remarkable" remission rates in the 50% to 85% range, said Nirali Shah, MD, head of the hematologic malignancies section of the Pediatric Oncology Branch at the National Cancer Institute (NCI).

The most recent results presented at this year's annual meeting of the American Society of Clinical Oncology support earlier efficacy data, she noted. In the longest follow-up to date, researchers reported remissions lasting over 9 years in patients with relapsed/refractory B-cell lymphoma or CLL treated with Kite's axicaptagene cilleucel (Yescarta), one of two anti-CD19-directed CAR T-cell therapies approved by the FDA in 2017 (the other is Novartis' tisagenlecleucel [Kymriah]).

This study included 43 patients and showed an overall remission rate of 76%. Complete remission was achieved in 54% of patients, and 22% had partial remission.

The other focus is long-term safety. Although some of the long-term adverse effects are known and are manageable, others fall into the theoretical realm. In early May 2020, the NCI held a multidisciplinary virtual conference on CAR T-cell therapy "to encourage collaborative research about the subacute and potentially long-term toxicity profile of these treatments."

"We know just a little at this point about late- and long-term effects of CAR-T therapy, because we are relatively early in the era of CAR T cells," said Merav Bar, MD, from the Fred Hutchinson Cancer Research Center in Seattle, Washington.

What is known is that B-cell aplasia represents the most common long-term adverse effect of CAR T-cell therapy. B-cell aplasia results when anti-CD19 CAR-T therapy wipes out healthy B cells as well as the malignant ones responsible for leukemia/lymphoma.

As major players in the immune system, B cells are a key defense against viruses. So B-cell aplasia represents a very specific type of immunosuppression. It is generally less severe than immunosuppression that occurs after organ transplant, which hits the immune system pretty much across the board and carries a much higher risk for infection.

The main concern is what happens when someone with B-cell aplasia encounters a new pathogen, such as SARS-CoV-2.

After infection, B cells generate memory cells, which are not killed off by anti-CD19 therapy and that stick around for life. So a patient such as Olson would still make antibodies that fight infections they experienced before receiving CAR-T therapy, such as childhood chickenpox. But now they are unable to make new memory cells, so these patients receive monthly immunoglobulin infusions to protect against pathogens they have not previously encountered.

Olson takes this in stride and says he isn't overly worried about COVID-19. He follows the recommended precautions for a man his age. He wears a mask, washes his hands frequently, and tries to maintain social distancing. But he doesn't stay locked up in his New Hampshire home.

"I took the attitude when I was diagnosed with cancer that I'm going to live my life," he said. "Quality of life to me is more important than quantity."

Another problem is the possibility of neuropsychiatric toxicity. Past studies have reported a wide range of such toxicities associated with CAR T-cell therapy, including seizures and hallucinations. Most have occurred early in the course of treatment and appear to be short-lived and reversible. However, there remain questions about long-term neuropsychiatric problems.

In a long-term study of 40 patients with relapsed/refractory CLL, non-Hodgkin lymphoma, and ALL, nearly half of patients (47.5%, 19/40) self-reported at least one clinically meaningful negative neuropsychiatric outcome (anxiety, depression, or cognitive difficulty) 1 to 5 years after anti-CD19 CAR T-cell therapy. In addition, 37.5% (15/40) self-reported cognitive difficulties.

"Patients with more severe neurotoxicity showed a trend for more cognitive difficulties afterwards," said Bar, senior author of the study.

However, teasing out the role that CAR T-cell therapy plays in these problems poses a challenge. All of these patients had been heavily pretreated with previous cancer therapy, which has also been associated with neuropsychiatric problems.

"So far, we don't know what caused it," Bar said. "Nevertheless, people need to pay attention to neuropsychiatric symptoms in CAR T-cell therapy. It is important to continue to monitor these patients for these issues."

Another potential problem is graft-vs-host disease (GVHD). This is not uncommon after hematopoietic stem cell transplants. It develops when the donor T cells view antigens on healthy recipient cells as foreign and attack them.

For patients who are treated with CAR T cells, GVHD is mostly a concern among individuals who have previously had a transplant and who are already at increased risk for it.

In a study of late effects among 86 adults treated with anti-CD19 CAR T cells for relapsed/refractory non-Hodgkin lymphoma, Bar and colleagues found that GVHD occurred only among patients who had received a previous donor stem cell transplant. Of these, 20% (3/15) developed GVHD about 28 months after CAR-T therapy.

"The data for CAR T cells causing GVHD really hasn't shown that it's a huge problem, although we have seen it and are continuing to monitor for it," the NCI's Shah commented to Medscape Medical News.

A range of other long-term adverse effects have been reported with CAR-T therapy, including prolonged cytopenias (reduced mature blood cells), myelodysplasia (bone marrow failure), and second malignancies.

In the study with the longest follow-up to date, 16% (7/43) of patients developed second malignancies, which is comparable to data from Bar's study in Seattle (15%, 13/86). The researchers in this study consider this rate to be no higher than expected: these patients had already received extensive chemotherapy, which increases the risk for other cancers, they point out.

However, this brings up theoretical concerns about the long-term effects of gene modification. CAR T cells are engineered using retroviruses (mainly lentiviruses), which randomly insert the CAR genes into the host genome. Doing so may cause mutations that could promote cancer. These lentiviruses also carry the theoretical risk of becoming capable of viral replication once inside the body.

To address these concerns, viruses used to engineer CAR T cells go through comprehensive safety testing. After therapy, patients are checked every few months during the first year and annually after that.

So far, there have been no reports of cancers associated with CAR T-cell therapy.

"Any type of cancer is a very theoretical risk," Bar told Medscape Medical News. "Most likely the malignancies in our study were related to prior treatment that the patients received. None of them had any evidence of replication-competent lentivirus, or any other evidence that the malignancies were related to the CAR T cells."

Another theoretical concern is the possibility of new-onset autoimmune disease, although, once again, no cases have been reported so far.

"We think of it as a theoretic possibility. Whenever you jack up the immune system, autoimmune disease is a potential risk," said Carl June, MD, director of the Center for Cellular Immunotherapies at the University of Pennsylvania.

June was the coprincipal investigator of the trial in which Olson participated. He is also the inventor on patents for CAR T cells licensed by the University of Pennsylvania to Novartis and Tmunity and is a scientific founder with equity in Tmunity.

Still, autoimmunity could occur, and scientists are looking out for it.

"We are continuing to be vigilant in our monitoring for autoimmune disease," Shah added. "We've been doing CAR T-cell therapy since 2012, and I think we have yet to see true autoimmunity beyond GVHD."

In the 10 years since Olson received CAR T-cell therapy, an entire industry has sprung up. Over 100 companies worldwide are now developing CAR T-cell therapies targeting various antigens. These therapies are directed at about 60 different tumor types, including solid tumors. Nearly 200 clinical trials are underway, though most are still in early stages: as of September 2019, only 5% had reached phase 3.

Clinical data show promising results for CAR T-cell therapy directed against CD22 (overexpressed on ALL cells), and BCMA (found on almost all multiple myeloma cells). Yet questions remain as to whether CAR T cells will be as effective if they target antigens other than CD19 or cells other than B lymphocytes. One of the biggest research questions is whether they will be effective against solid tumors.

One research avenue being watched with great interest is the development of universal CAR T cells. So far, such products are at very early stages of development (phase 1 trials), but they are attractive because of the potential advantages they offer over bespoke CAR T cells. Automating the process holds the promise of immediate availability, standardizing production, expanding access, and lowering costs. And because the T cells for this universal product come from healthy donors, they may function better than T cells that have been battered and bruised by past cancer treatments, or even the cancer itself.

However, precisely because they are developed from healthy donor T cells, universal CAR T cells may pose increased risk for GVHD. Scientists are trying to get around this problem by engineering universal CAR T cells that lack the T-cell receptor involved in GVHD.

There are also other concerns. Nature has a penchant for mutation. Engineering CAR T cells without T-cell receptors means the body may no longer detect or reject a universal CAR T cell if it goes rogue. Also, gene insertion in universal CAR-T therapy is targeted rather than random (as in bespoke CAR T cells), which could create off-target effects. Both issues create a theoretical risk of such products inducing an untreatable CAR T-cell therapyassociated cancer.

"The theoretic risk with universal cells is that their safety profile may not be as good for long term," June commented.

From that first trial in which June and Porter used CAR T cells, two of three patients they treated are still alive 10 years later.

Olson is one of these two, and he still undergoes monitoring every 3 months to check for relapse. So far, none of his tests have shown signs of his cancer returning.

After going into remission, Doug spent the next 6 to 9 months regaining his health and strength.

"I figured if I had this amazing treatment that saved my life, I had an obligation to stay alive," he said. "I'd better not die of something like a heart attack!"

He took up long distance running and has completed six half marathons. He became involved in the Leukemia and Lymphoma Society, participating in fund-raising and helping newly diagnosed patients. Over the years, he has also given talks for researchers, people with cancer, and healthcare providers.

Doug is now 73. Today, he marvels at how rapidly the CAR-T field has progressed.

"Twenty years ago, if you had cancer, your prospects weren't nearly as good as these days. In 2010, people still didn't believe in CAR T-cell therapy," he said. "My goal always in telling my story is a message of hope."

For more from Medscape Oncology, join us on Twitter and Facebook.

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In Remission for 10 Years: Long-term Data on CAR-T Therapy - Medscape

MCs, Stunts and Doing Keys: Behind the Scenes With Bad Boy Chiller Crew – VICE UK

It's the tail end of 2019 and Bradford's Bad Boy Chiller Crew are setting the stage alight at Trance Party, a regular night at South London's Corsica Studios. Alongside electronic artists like Varg2 , Total Freedom and Lisa Pinup, the three of them stick out like a ket halo. But their frenetic topless bassline MCing quickly turns the crowd into instant fans PC Musics Danny L. Harle is at the front with his hands in the air, and the atmosphere is sweaty and full on. Afterwards, BBCCs Gareth Kelly otherwise known as GK heads to the green room, getting emotional. It's the biggest night they've ever played, he says, and it means a lot.

BBCC made up of GK, MC Clive and Kane are more than a crew. They're an autonomous media company. They've remixed UK garage tunes into Bradford-style bassline bangers. They've released branded music partnerships with a carwash. They've created their own universe of comedy characters online, based on their experiences growing up on council estates. And their Jackass-style skits have been getting serious organic numbers over 150 million, according to their manager Darren AKA Dr Google (his dad used to run an adult website, Go Ogle, hence the name.) In one video, Clive (the one with the mullet), puts a traffic cone to his mouth while the rest of them pour whatever drinks they can find down it, cans and all. I had to go and meet them for myself.

VICEs Tir Dhondy with S-Dog, Kane, GK and Scum.

Myself and VICE host Tir Dhondy wound up driving to Bradford to film BBCC and the West Yorkshire rapper S-Dog for a documentary about the trio, which you can watch below. Crowded into a small studio in someone's back garden, they came across like a hit-making machine; churning out two brand new belters in a few hours, with each MC taking turns to spit bars about doing keys, copping three Phantoms and local fiends robbing goldfish from Pets At Home.

Tir asked them why they chose to MC over bassline rather than something like drill. Kane shrugged. Its what we like. Its what we listen to, he said, simply. Its always been popular in Bradford, GK laughed, 'cause were still 20 years behind!

GK might be joking but he's got a point: breathing new life into forgotten genres is a rich tradition in regional scenes in the UK. BBCCs music and antics could be seen as belonging to a bygone era, one we recognise from the 2000s, but which now only exists in Facebook echo chambers. Their world is an irresistibly nostalgic jacuzzi bubbling with UK bassline, stunts, sesh culture and people calling each other charva. Even so, it seems to have built them an army of new young fans, and in quite a short space of time.

S-Dog, Kane & MC Clive in their mates studio in Bradford

After their studio sesh, Tir and I jumped in their BBCC branded van. They took us to a spot affectionately dubbed, Top O World a hill overlooking their estate so I popped off some stills.

MC Clive next to BBCCs branded van

A week later, we returned to Bradford to catch them performing a gig for their underage fans at a local social club ahead of their then-upcoming world tour, which before the coronavirus pandemic was supposed to take them to destinations as far-flung as China, according to Dr Google.

Outside the venue, legions of kids sporting MC Clives trademark mullet were hanging about in groups. Tir asked one of them if the mullet was a popular haircut in Bradford. Oh yeah, mullets and curtains are, he said, before going on to promo his own MC crew. These kids are barely in their teens, meaning they definitely wouldn't have been around for the first wave of UK bassline. It might be a stretch to claim that BBCC are kickstarting a bassline renaissance, but they're definitely ushering in a moment right now.

From left to right: GK, S-Dog, MC Clive and Kane.

A couple of the kids had bunked off school to get tickets and a glimpse of the crew. Do you actually do coke? one of them asked BBCC, followed by fits of laughter from GK and Kane. With lyrics like, Lines of the flake to get my heart pumping, and Put your guns in the air and get your keys out, it's not an off-topic question. Tir asked them why they mentioned drugs so much. Were just demonstrating what weve been brought up around, explained GK. We believe taxpaxers' money dont make Bradford go round, its white and brown powder. More fits of laughter followed.

MC Clive, Kane, S-Dog and GK at 'Top O World' in Bradford

As the gig kicked off, hundreds of kids started shouting along and even grabbing the mic themselves to perform their own renditions of their favourite BBCC tracks. The vibe had the same energy as the time I watched the Vengaboys at a Mecca Bingo in Southend-on-Sea euphoric, candy blasts of bassy pop where you unconsciously knew most of the words but had no idea why. (The lads also cite the Vengaboys as a major influence.)

After the show, Dr Google took to the stage to announce the winners of a raffle another way of generating income and we spoke to the lads for the last time IRL. Whats next for the Bad Boy Chiller Crew? asked Tir, congratulating them on their performance. Kane seemed hyped. Were goin on tour mush and were goin divvy, he replied, oblivious, like the rest of us, to the global pandemic which lay ahead.

Since COVID-19, the lads are having a Beatles-style Hamburg moment. They've relocated to Dr Googles permanent residence in Minsk, Belarus, to escape the UK, hone their craft and for GK to finally get the chest reduction surgery hes always wanted. In the meantime theyve been pumping out the social content, from GK documenting his hospital experience to bottle service club appearances with live snakes to MC Clive necking an entire bottle of voddy and shitting in Dr. Googles prosthetic leg.

Right before the documentary's release, I arrange a Zoom screening with BBCC and the London label House Anxiety, who released their recent single 450 ft. S-Dog and EP Full Wack No Breaks. The crew all answer the call topless while getting massages in their hotel room. Its probably the strangest screening Ive ever done, but I'm relieved to hear they enjoyed the film, with Dr Google giving us his seal of approval. I reckon thisll put VICE on the map, he says.

@avantgrant

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MCs, Stunts and Doing Keys: Behind the Scenes With Bad Boy Chiller Crew - VICE UK

Tisto to unveil VER:WEST at Tomorrowland’s Around The World – Dancing Astronaut

by: Jessica MaoJul 14, 2020

Following a taste of his upcoming side project VER:WEST, Tisto has revealed he will debut the new alias at Tomorrowlands digital event, Around The World. The hotly-anticipated virtual festival will welcome an extensive selection of talent including Martin Garrix, David Guetta,Armin van Buuren,Charlotte de Witte,Tale Of Us, and the recently-announced Katy Perry, among many others. Around The World will take place the weekend of July 25-26.

Tisto first previewed VER:WEST on July 9, hinting at a return to his classic trance and progressive house roots, before sharing the project would be unveiled at Tomorrowlands forthcoming event. The Dutch DJ described the direction as melodic house, noting VER:WESTs sound as, a lot deeper and more chill, a very different energy than Tisto. The upcoming single 5 Seconds Before Sunrise, is slated for release July 17 via AFTR:HRS.

Featured image: Jordan Loyd

Tags: Around the World, festival, melodic house, tiesto, Tisto, tomorrowland, VER:WEST, virtual

Categories: News

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Tisto to unveil VER:WEST at Tomorrowland's Around The World - Dancing Astronaut

Back in the pool: the new rules of swimming – The Irish Times

I missed swimming so much in lockdown; a bit for fitness, but mainly for its magical effect of processing a grumpy mood into a light one.

Everyone was raving about the sea, but while the endorphins from the cold water shock were welcome, two minutes was enough. And when a friend got bitten by a jellyfish I got wary.

Ben Dunne might want to close his pools but with 6.2 per cent of Irish adults swimming over 30 minutes weekly (according to a ESRI/Swim Ireland report) - there would have been a large cohort like me missing their fix.

I love the pool because I can zone out - after five minutes I go into a kind of trance thats really calming. I used to go three times a week - around 20 minutes swimming, a nip into the sauna followed by a splash of cold water in the shower - and I never realised, until it was gone, how much this routine enhanced my week.

But now its back.

My pool is in a gym, The Dartry Health Club, and while gym users cant shower, thankfully swimmers can as heading home in wet togs holds little appeal.

You have to book your slot a generous 75 minutes.

In the changing rooms every second and third locker is closed off to allow for two metres social distancing.

Apart from fewer people and no hair dryers even the machine that dries the swimsuits was off it was a lovely return to normality; lowering myself into the water the pandemic felt like a bad dream. Everything was clean and with reduced numbers there was no problem keeping a distance.

Manager Sen Gavin said demand was strong with the booking system going down well with aqua aerobics particularly popular (classes are now halved to 10 places) even though some attending this class are in their 70s and 80s.

Next on his agenda is figuring out where to put the family swims and to sort the kids swimming lessons.

I was sad to see the sauna closed and professor emeritus of epidemiology of infectious diseases at University of Nottingham Keith Neal told me this would be low down the reopening list. Although the heat and dryness of saunas mitigates against risk, the problem is distancing in a very enclosed space with multiple people.

The HSE has said coronavirus cant be transmitted in properly chlorinated water and Neal was unequivocal about the impossibility of picking up the virus in the water. The chlorine in swimming pools kills Covid-19. No ifs, no buts, it kills it. I think the big issue is the changing facilities and showers and maintaining safe distances and clean surfaces.

Pools could reopen on June 29th and while many did, large numbers of Irelands 398 pools (of which 35 per cent are public) will only open this week - with a few waiting later still.

The reason, according to Trish Mayon of Swim Ireland, is that initially pools were aiming towards phase four of the roadmap. Many of the bigger groups, such as Coral Leisure, which has nine pools around Ireland, were waiting until July 20th (as per) the initial announcement. The same for Gym Plus in Ashbourne, Drogheda and Newbridge, and Kingfisher in Galway and Waterford. There was just one weeks notice of the earlier date and it was insufficient to get facilities prepared, to bring staff off furlough, and in some cases, re-fill the pools.

She said 300,000 adults swim weekly so there will be many eager to get back this week, along with the thousands of children who swim regularly.

We have 160 swimming clubs around Ireland and its been a long, tough stretch though it could be worse with the 60 pools in Northern Ireland not allowed open until August 7th, she said.

Swim Ireland have detailed plans on their website offering advice on how to reconfigure changing rooms and safely give lessons such as the instructor remaining on deck and not giving out equipment but says, depending on size, there has been a mix of approaches to opening.

The Swan Centre in Rathmines in Dublin are members only for the moment. There is a one in, one out system with manageable numbers so far for family swims and lane swimming.

Lorcan Beggan is a swimming teacher who has been answering the phones until the lessons start again this week, and says so far theres been no need for a booking system but he is conscious that non-members are keen to get back.

UCD are also on normal hours with no need to book, though you might need to wait a few minutes at certain times. The lanes have been widened - instead of 10 there are five - with every second shower closed. They are now running the childrens swimming lessons that had been cancelled.

Dublin City Council runs seven pools. Ballyfermot and Markievicz have been open for weeks, with Crumlin and Coolock to open this week or shortly. Another three-Sean McDermott Street, Ballymunand Finglas - are closed for repairs.

The Markievicz is open to all, though non-members need to provide contact details. They are open as per pre-lockdown hours and run a coloured armband system to show what time you got in, with one hour allowed.

Robbie Murtagh says numbers have been steady with all the hardcores who come at 7am back.

In Ballyfermot you need to book your 45 minute slot, with the pool open just four days a week with a maximum of 16 people.

Duty manager Amy Heather says the over 60s have been especially keen, with their initial two hour slot increased to four hours. They close the pool to clean after each session, with just half of the 32 cubicles available. Its bonkers the demand. The customers missed it, we all did. Were delighted to see each other. Its been no issue getting them back in the door. Trying to get them to leave thats the problem.

Continued here:

Back in the pool: the new rules of swimming - The Irish Times

People who are easily hypnotized are more likely to be addicted to their smartphones, study finds – PsyPost

New research published in Frontiers in Psychology suggests that being absorbed by your smartphone might bear some resemblance to a hypnotic trance. A hypnosis experiment found that students with heightened smartphone addiction scores followed more hypnotic suggestions than their counterparts.

Study authors Jay A. Olson and his team were the first to explore the relationship between smartphone addiction and hypnotisability. They propose three features that problematic smartphone use and hypnosis have in common: absorption, time distortion, and automaticity. Heavy smartphone users tend to get absorbed in their screens, lose track of time spent on their phones, and feel a loss of control when using their phones behaviors that suggest a trance-like state.

If heavy smartphone use can resemble hypnosis, Olson and colleagues say, people who are more hypnotisable may also be more prone to problematic smartphone use, in which phone use interferes with daily life.

A sample of 641 university students with an average age of 21 took part in a hypnosis experiment. Students first listened to a 45-minute audio recording designed to induce hypnosis. Next, they heard 12 verbal suggestions, for example, a suggestion that the subjects head will fall forward or that they will be momentarily unable to open their eyes. Following the 12 suggestions, subjects were led out of hypnosis and asked to complete a questionnaire asking them how many of the prompts they had followed. They then completed the Smartphone Addiction Scale to assess how much their smartphone use disrupts their normal life, which included items like, I feel impatient and fretful when I am not holding my smartphone.

Results showed a positive correlation between participants scores on the Smartphone Addiction Scale and the number of hypnotic suggestions they followed.

The authors propose two underlying psychological constructs that might explain the relationship between smartphone addiction and hypnotisability. The first is dissociation, which is when a person disengages from the sense of self or the environment. Previous research has uncovered dissociative tendencies in subjects who are easily hypnotized and also in subjects who display problematic technology use. Another construct possibly linking the two behaviors is sociality. Hypnotisability, the authors say, may be related to ones tendency to respond to social cues, and using phones for social purposes has been linked to addictive behavior.

The prevalence of problematic cell phone use was particularly high in this study. The average score for participants was 31.41, which, as the researchers report, means that 51% of the women and 39% of the men would have a high risk of phone addiction.

Since developers stand to gain more data collection and advertising revenue by keeping users engrossed in their phones, smartphone technology is likely to become still more immersive. The authors suggest this may increase users problematic behavior. To reduce automatic interactions, Olson and team suggest, behavioural interventions could reduce the salience of the phone or make it more effortful to use, for example by keeping the phone further out of reach or limiting sporadic notifications.

The study, Hypnotised by Your Phone? Smartphone Addiction Correlates With Hypnotisability, was authored by Jay A. Olson, Moriah Stendel, and Samuel Veissire.

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People who are easily hypnotized are more likely to be addicted to their smartphones, study finds - PsyPost

INTERVIEW | Gautham Menon feels a big film is all that is needed to bring audience back to theaters – The New Indian Express

Express News Service

Discovery Channels latest documentary, COVID-19: India's War Against The Virus, which is getting released today, comes at a time when the country is still battling the coronavirus pandemic. Extensively shot during the lockdown, the documentary is said to be shedding light on how technology is being used to combat the virus, and also on those working tirelessly behind the scenes to arrest the spread of this disease.

The Tamil voiceover for this show is lent by Gautham Vasudev Menon who is donning the hat of a narrator for the first time. I got a call from Discovery and agreed straightaway. I got to dub it with Mahesh along with whom Ive dubbed during the Vettaiyaadu Vilaiyaadu days. The concept of the documentary convinced me to step out from the safety of my house, says Gautham, opening up about several topics, including the status of his films, through a video call.

What was it to be a part of a documentary about something as pressing and momentous?

It felt like a personal thing and thats why I agreed to do this. I ventured out just to recognise the war we are waging against the virus, and talk about people in the frontlines who have done their part, what the statistics say, and what progress we have made.

Even the Chennai floods was captured as a moving documentary. What should we expect from this documentary?

Theres a lot of work that has gone into it, and I could figure this from watching the rushes. Its not just a compilation of bytes. Painstaking effort has been taken amidst the lockdown to make this film. There are some great shots, and the film has everything from the PMs speeches to conversations with the people working in the health department, and front line people such as the police officers, doctors and nurses. It has also covered the whole transport system that has gone into gridlock, and covers migrants too. Every nuance is covered and its put out in a manner where it leaves you with hope in the end. Its telecasting at a time when we are in the middle of a war and I hope they come up with a part two of the documentary to tell everyone how we have won that war.

We know about your love for voiceovers but what is it like to offer your voice for a film you havent created?

I felt one with it. I was hoping that the script will take a personal narration approach instead of just an overall voiceover. This was done in a personal manner and I even get to say, I, Gautham Vasudev Menon, am going to take you through Indias war against the virus. I say this in Tamil obviously (smiles).

We see channels like Discovery and platforms such as Netflix, with whom you are working on a project as well, beginning to concentrate more on regional content.

We have always been on the map. As far as filmmakers that have come from here are concerned, I think its about time we were in all these platforms. Theatres are not going to be open about taking in every film... the small films dont get noticed at all. The way I look at it, we were always there, but now we are flooding these platforms.

We have seen you get into mainstream acting in films like Trance and Kannum Kannum Kollaiyadithaal, and sing in films like Puppy and Takkar. Is this reinvention of your presence in the industry in a sense?

(Smiles) I dont look at it that way. Its just like how I write my scripts. I have no idea whats going to come up and sometimes, nothing comes up. But I love the process. I dont have plot points and I just let it meander as a river would. Whatever roles you have seen me playing are all that I felt like doing at that moment. I did Trance because of Anwar Rasheed (director) and Fahadh Faasil. I am a fan of Fahadhs work and I have heard so much about Anwars work. It was a wholesome enriching experience to watch them at work. Kannum Kannum Kollaiyadithaal happened because Dulquer asked and there was a like-minded producer. For this documentary, I felt it would be right to be a part of it.

You recently released a song called Oru Chance Kudu single, a short film called Karthik Dial Seytha Yenn, and two singles from your upcoming film, Joshua Imai Pol Kaakha. The lockdown seems to have been productive for you.

These are unfortunate times, but silver linings have been there. I spent a lot of time at home. Its sad that something like this has to happen for us to scamper home. The uncertainty is bothersome, as theatres are not opening and shooting too is not allowed. Its all about safety right now. Whatever you write, you realise you cannot go out and film, so your writing gets changed to what can be done right now and I feel that its not good. That said, so much time has given me the space to know people a lot more.

Whats on your plate now?

Karthik... was an excerpt from a script that I was writing and I thought it could be filmed and put out. I want it to serve as a reminder and a prologue for a film thats going to come up. I am writing that and I am waiting for a few things to fall in place. I also have something for Suriya and we are in alignment. Nothing is confirmed, but I hope it will be soon. I also have Joshua and Dhruva Natchathiram set for release. Both films have about a dozen days worth of work left. Post-production has been happening on full swing and we are working remotely.

Once the world returns to normalcy, how do you see the film industry being?

I think one big film here and in Mumbai will bring the crowd back to the theatre. Thats the passion that drove us to do films -- to put films out in the theatres. OTT is also a platform for people to put out different content and its a boon. Right now, everyone is seeing if we can film under safe conditions and a lot of discussion is happening on how safe we can make the sets. I dont think its as easy as wearing a face mask and going to shoot. At the same time, we are hoping for some miracle vaccine.

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INTERVIEW | Gautham Menon feels a big film is all that is needed to bring audience back to theaters - The New Indian Express

Around the Bluhmin’ Town: Dog days of summer have arrived – Verde Independent

Did it rain enough? Probably not. Is it hot enough?

Hmm, lately it feels as though we are in the midst of the dog days of summer. This phrase was originated in ancient Roman times, used to describe the intense heat of summer. The term has been widely used ever since.

The ancient astronomers noted that Sirius, the Dog Star, rose and set with the sun during July and August. It was then concluded that the Dog Star and the suns heat combined, caused the hottest weeks of the year. Hence, we are in those dog days.

Doggone it, I thought the phrase had something to do with feeling like sitting around and panting like a dog when it is an inferno outside. I must start looking upward, toward the sky and try and locate this Dog Star, Sirius. If he is the culprit for these heat waves, dust devils, lightning and wind, then Id like to have a few choice words with this dog. (Oops, I must remember that this is a family paper).

I hate to complain, after all, at least we arent living in Death Valley. A woman who just moved to Arizona, emailed me to say that she is trying to learn to appreciate the oppressive heat. She is keeping a watchful eye for all things special about blazing, hot days and has encouraged all of her friends and neighbors to do the same. Hmm, I did see a massive yellow wall of dust moving my way last week, as I was driving in Phoenix. Surely, a haboob has to qualify as special.

Whats so special about the dog days of summer? Actually its a time of great hope. Everyone I talk to is looking forward to something different or hoping to go someplace else. We dream of cooler days. Okay, so the pandemic has dashed many of our plans. But beaches are still beckoning. Family road-trips await. Camping in the pines sounds pretty thrilling. And cool, rainy days might be arriving soon.

Arizona seems to be getting hotter. Triple digits in Phoenix is always routine, but Prescott has seen 100 degrees! Ouch! Its as though we get through a hot spell in some sort of collective trance, just waiting for a break in the weather or a change of scenery. We are strong people in Arizona! We can endure a pandemic, stifling hot weather and still love this place. Dog Days? Bring them on! Who is afraid of a little heat?

Summer brings sunsets always worth watching. Lightning may be dangerous, but it sure is beautiful. And what could be more fun then standing outside in a rainstorm when it finally hits? (Some folks do this naked please dont). The Navajo claim that when the clouds look like sheep in the sky, rain is coming. I am always on the look-out for sheep. As the Hopi say, Monsoons bring magic.

Dear Readers, enjoy the magic! And just getting through the monsoons is a pretty special experience. Try to get wet! Look for sheep in the sky and think cool thoughts. Better days are coming.

Judy Bluhm is a writer and a local realtor. Have a story or a comment? Email Judy at judy@judybluhm.com.

See the article here:

Around the Bluhmin' Town: Dog days of summer have arrived - Verde Independent

Tomorrowland Around the World is happening this week! – Rave Jungle

On Saturday July 25 and Sunday July 26, worlds best music festival, Tomorrowland is organising Tomorrowland Around the World, a spectacular entertainment experience open to people of all ages and places, unfazed by borders or boundaries a world premiere and a major step in the future of digital music festivals.

For its inaugural edition the team behind Tomorrowland Around The World will be bringing together more than 60 of the worlds most prominent artists in electronic dance music with spectacular special effects and astonishing 3D-technology.

Headlined by global pop superstar Katy Perry the two-day festival weekend, will include unique performances by the likes of Adam Beyer, Amelie Lens, Armin van Buuren, Charlotte de Witte, David Guetta, Dimitri Vegas & Like Mike, Klsch, Lost Frequencies, Martin Garrix, Paul Kalkbrenner, Steve Aoki, Tale of Us, Tisto, Timmy Trumpet and many more.

Check out the full lineup below!

Catering to all genres with an eclectic line-up, from trance to hardstyle, to house to dubstep and future bass, there is definitely something for everyone during the unprecedented two-day festival experience.

Tomorrowland Around the World will offer a packed schedule and is using the worlds best technology in 3D design, video production, gaming and special effects to bring together 8 different stages, including the iconic Mainstage that gives a first introduction into the magical world of The Reflection of Love Chapter 1, plenty of signature Tomorrowland stages such as Atmosphere, Core and Freedom Stage, joined by 3 new stages, which have been specially created and designed by the creative team and 3D artists behind Tomorrowland.

In an exclusive sneak preview, Tomorrowland is giving a very first look into the magical and newly created Tomorrowland location it has been building over the past few months, giving people across the globe a first taste of the dazzling world they will be able to navigate through during Tomorrowland Around the World, the digital festival.

Each stage will also premiere brand new music and video content from the worlds best artists and a large portion of the fireworks and laser shows characteristic of Tomorrowland.

As with the other editions of Tomorrowland, the festival always wants to offer its guests much more than music and spectacular shows. In these special times, the People of Tomorrow are discovering and creating new ways of living. During its digital edition, Tomorrowland Around the World will host a number of entertaining Inspiration Sessions by 16 internationally renowned thought leaders from different fields to offer people a substantial extra dose of positivity and inspiration, in addition to all the amazing musical content.

Unique role models and experts, including former NBA champion Shaquille ONeal, Black Eyed Peas frontman will.i.am and Cirque du Soleil founder Guy Lalibert will share, from their homes, energizing messages that uphold Tomorrowlands core values Live Today, Love Tomorrow, Unite Forever. All Inspiration Sessions will be available to the visitors during the entire festival weekend.

Tomorrowland Around the World will welcome 16 international thought leaders from different backgrounds that will be hosting the Inspiration Sessions: Adrien Moisson, Arnoud Raskin, Ben Francis, Bethany Hamilton, Boyan Slat, Gaggan Anand, Guy Lalibert, Ida Engberg, Johan Ernst, Prince Ea, Ran Tellem, Shaun Ross, Shaquille ONeal, Sebastian Wussler, will.i.am and Yamashita Tomohisa. They will each share their stories with the world, from their homes, about passion, strength, creativity, solidarity, sustainability and more. Each session will last 10 to 15 minutes and will be available to all festival visitors during the entire weekend.

Tastes of the World and Netsky bring you four inspiring dishes and recipes to prepare you for the Tomorrowland Around The World festival. Get behind the cooking pots or fire up the BBQ and take your festival experience to the next level. Learn to cook some amazing food with world-class chefs with easy to follow videos and recipes to download. More info here.

Festival visitors will be able to navigate easily through a magical and newly created Tomorrowland location with a PC, laptop, smartphone or tablet you dont need special VR goggles and explore the entire festival site in an interactive way together with friends. Besides the performances there will be all kinds of interactive experiences to choose from, including inspirational webinars, games and workshops related to lifestyle, food, fashion and the Tomorrowland Foundation.

Together with the performances, Tomorrowland Around the World will be a full day/weekend experience between 15h0001h00 CEST. There will be a time-zone-friendly option for visitors from Asia and North or South America.

The People of Tomorrow are invited to experience this unique event together with friends: dressing up with your best festival outfit, putting up tents in your back garden to create your own DreamVille, setting up a big screen, inviting your beloved ones for a nice barbecue with music and an amazing festival experience, decorating your balcony or throwing a party in your living room this weekend is all about uniting through the power of music in a responsible and safe way.

Tickets forTomorrowland Around the Worldare now availablehere.

Day ticket costs 12.50. Weekend ticket costs 20.00 and includes a week of video-on-demand content to relive the entire experience. Special People of Tomorrow packages and Home Party packages are available. More info can be foundhere.

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Tomorrowland Around the World is happening this week! - Rave Jungle

Caribbean Cruises 2020 (from $272): Compare Deals on …

Why Cruise to the Caribbean?

Thousands of islands make up the Caribbean, a tropical region stretching across the Atlantic Ocean. Home to some of the most popular cruise ports in the world, the Caribbean offers variations on a theme: sun, white-sand beaches and fun with a local twist, depending on the port. From Dutch and French isles to U.S. territories, the destinations of the Caribbean have cultural experiences to spare that extend well beyond the tip of the umbrella in your fruity cocktail.

A cruise offers the chance to visit multiple islands within the span of a few days, providing visitors with a sampler of new places plus balmy sea breezes along the way. Caribbean cruises offer endless variety giving vacationers the chance to get away for a long weekend or two weeks. With so many departure ports, your ship to the Caribbean might be a short flight or even a drive away.

The Caribbean offers as much -- or as little as you want to do during your time ashore, making it an ideal cruise vacation for families or for couples.

Water sports are abundant in the Caribbean and anyone who likes spending time in the sea will enjoy snorkeling, diving, paddleboarding and swimming through clear, turquoise waters like the remote beaches of Bonaire. Or fly high through the sky on a number of active zipline courses, including the steepest zipline in the world in St. Maarten. Lazily lounging on the beach is almost always a fantastic option. Pair a beach day with a hike on a day trip from St. Thomas to Virgin Island National Park in St. John.

If you need a break from the sun, air-conditioned island tours, duty-free shopping trips and even scenic rail trips -- such as the one around St. Kitts -- provide wonderful ways to spend a day off the ship.

All-inclusive lovers will be able to pamper themselves with excursions to resorts, while those looking for a more local flavor will be able to learn from chefs, artisans and other experts for an authentic taste of each island's culture

Winter and spring are great seasons to travel to the Caribbean due to a slight reduction in crowds and moderate temperatures, though the warm weather holds year-round here.

Atlantic hurricane season, from June through October, means a higher chance of rain and possible storms, though summer is still one of the most popular times to visit the Caribbean. If you book a summer sailing in a Caribbean region within the hurricane zone, there's a chance nothing will happen -- but buying insurance and keeping a flexible schedule helps manage expectations.

Cozumel, St. Thomas, Grand Cayman and St. Martin/Maarten are some of the most common ports of call in the Caribbean. You could also experience Jamaica, Cuba, Aruba, Grand Turk or the Dominican Republic. Many Caribbean cruises also include stops at private islands, such as Royal Caribbean's CocoCay or Disney's Castaway Cay, located in The Bahamas.

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Caribbean Cruises 2020 (from $272): Compare Deals on ...

Collaboration is key to accelerate resilient solar projects in the Caribbean – Power Engineering International

Collaboration amongst policymakers and regulators will help accelerate the resiliency and installation of solar projects across the Caribbean, according to a new report.

The report has been released by the Rocky Mountain Institute (RMI), the Clinton Foundation and the United Nations Office of the High Representative for the Least Developed Countries, Landlocked Developing Countries and Small Island Developing States.

The study highlights how solar projects can help improve communities livelihoods, enable cost savings, build resilience, and reduce dependency on foreign oil.

By collaborating, Caribbean island nations can ensure the correct equipment is available, known practices are enforced and that solar projects are developed and built with the highest standards.

Related articles:Solar installations market slows in China and IndiaSunny weather brings solar record to EuropeGlobal corporate funding for solar energy declines by 25%

Key recommendations for collaboration presented in theSolar Under Storm for Policymakersreport include:

The release of the study comes at a time grid networks in Caribbean and Small Island Developing States (SIDS) continue to be affected by more frequent and intense weather events. Due to severe weather, critical infrastructure like hospitals and schools are without power and communities suffer deeply.

Although solar PV systems are a way to increase the resilience of the grid and greatly improve peoples access to reliable electricity, they are useless if they are not resilient to severe weather.

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Fekitamoeloa Katoa Utoikamanu, high representative for the UN-OHRLLS, said: In the Sustainable Development Goals, the world committed to ensuring access to affordable, reliable and modern energy for all. Many Small Island Developing States are emerging as frontrunners in the pursuit of renewable energy, with solar power leading the way. International support in the form of access to finance, investments and technology will be critical to accelerate their transitionand their resilience.

The study is the third in a series of reports by RMI and partners that focuses on installing hurricane-resilient solar systems. The firstSolar Under Storm guidediscussed the root causes of past solar failures focused on ground-mounted systems.Solar Under Storm Part IIexplored best practices for equipment and procedures for rooftop systems.

Read more about thereport.

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Collaboration is key to accelerate resilient solar projects in the Caribbean - Power Engineering International

July 20 evening update: The latest on the coronavirus and Maine – Bangor Daily News

Another 24 cases of the coronavirus have been detected in Maine, health officials said Monday.

There have now been 3,711 cases across all of Maines counties since the outbreak began here in March, according to the Maine Center for Disease Control and Prevention. Thats up from 3,687 on Sunday.

Of those, 3,287 have been confirmed positive, while 424 are likely positive, according to the Maine CDC.

No new deaths were reported Monday, leaving the statewide death toll standing at 117. Nearly all deaths have been in Mainers over age 60.

Heres a roundup of the latest news on the coronavirus and its impact in Maine:

Even though the U.S. is planning to reopen schools as COVID-19 numbers across the country continue to rise, Maine is one of two states that recently has seen its number of cases decline. But rates of infection vary throughout the state, and sometimes from one neighboring school district to the next. And while there have been ample studies on how students benefit from learning in group settings, much about how the disease spreads among children even among those who dont show symptoms still is unknown. Eesha Pendharkar, BDN

Has the coronavirus made you late on housing payments? We want to hear from you. Michael Shepherd, BDN

The North Atlantic Conference, a Division III league that is home to five small colleges in Maine, announced Monday that it will not sponsor any fall sports competition in 2020. Pete Warner, BDN

Town clerks and state officials in Maine are turning their eyes toward November after a dress rehearsal that proved the state can run an election that relies much more heavily on absentee ballots. Patrick Whittle, The Associated Press

Daily Brief: How Maines delegation wants to continue virus aid as the Senate reconvenes Michael Shepherd and Caitlin Andrews, BDN

As of Monday evening, the coronavirus has sickened 3,816,427 people in all 50 states, the District of Columbia, Puerto Rico, Guam, the Northern Mariana Islands and the U.S. Virgin Islands, as well as caused 140,879 deaths, according to Johns Hopkins University of Medicine.

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July 20 evening update: The latest on the coronavirus and Maine - Bangor Daily News