‘Feels Good Man’ Will Try To Save Pepe The Frog, The Innocent Cartoon That Became A Hate Symbol – esquire.com

Pepe the Frog celebrated his fifteenth birthday this year, but chances are you first stumbled upon him during the 2016 US election in the pungent depths of a racist Twitter thread. That was the year when Matt Furies cartoon went from being a happy little frog to becoming the unexpected mascot of the alt-right movement.

The history behind Pepe is complicated bordering on indecipherable, much like anything that grew to prominence on 4chan, the controversial anonymous message board that has long harboured racists, sexists and political extremists. The cartoon first appeared as a meme on the forum in 2008 after being lifted from Furies 'Boys Club #1' comic strip, and it gained such popularity that even Katy Perry and Nicki Minaj shared Pepe images on social media. Eight years later it was official recognised as a hate symbol by the Anti-Defamation League. So what changed?

Feels Good Man, the Sundance award-winning documentary from Arthur Jones, follows Furie around as he attempts to repair his infamous cartoons reputation. But can Pepe be redeemed, or is he better left to fester with the white supremacists of the world? The fact that he has recently been co-opted by Hong Kong protestors would suggest that Furis frog still wields some power; that his prominent place in politics is, bafflingly, far from over.

Describing the film, director Jones says: The movie is really about him negotiating that uncomfortable reality for himself, [...] Matts personal journey really makes the movie really unique that I hope a lot of people find satisfying for a lot of reasons.

First and foremost, its a story about how powerless we become after we put something into the world. As Furie says: Im just a spectator to how things evolved on the internet.

Feels Good Man will be available streaming and on demand in the US on 4 September. A UK date is yet to be announced.

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'Feels Good Man' Will Try To Save Pepe The Frog, The Innocent Cartoon That Became A Hate Symbol - esquire.com

Disney Plus "Muppets Now" Zoom Video Call With Kermit the Frog And Friends – We Are Movie Geeks

In preparation for the world premiere of the Muppets first-ever streaming show, Muppets Now, Kermit the Frog will conduct a video chat to break the news that Disney+ has ordered six half-hour muppisodes premiering July 31. With a full roster of rotating guest stars, world-class production facilities, and pure unscripted mayhem, Muppets Now breaks new ground for the gang in their Disney+ debut.

The Muppets are thrilled to be doing our first-ever unscripted show! Its going to be extremely spontaneous and very surprising; almost as surprising as the fact that weeveractually used a script in the past.

This is moi unfiltered, unexpurgated, and more unbelievably fabulous than ever. If you watch only one show on Disney+ ,you really should tune in more often. But whenever you watch, make it moi onMuppets Now.

For the first time ever, Im working without a joke book, folks. Its a new kind of totally improvised comedy I call bare bear! See what I did there? Ahh! Wocka! Wocka!

I knewMuppets Nowwas coming to Disney+ but I did NOT know they wantedMuppets Now NOW, as in right away, as in doesnt anybody give a warning around here!? Gotta go upload those episodes pronto! Wish me luck; Ill need it.

This seasons celebrity guests include entertainers, comedians, chefs, and more. Fans wont want to miss all-new improvised comedy segments from their favorite Muppets including Miss Piggy, Beaker, Camilla, Dr. Bunsen Honeydew, Fozzie Bear, Gonzo the Great, Kermit the Frog, Pepe the King Prawn, The Swedish Chef, Scooter, Uncle Deadly, among others.

Disney+ is the streaming home for the Muppets collection where Muppets Now will join an assortment of fan-favorite Muppet movies, series, and shorts.

Produced by The Muppets Studio and Soapbox Films, Muppets Now premieres Friday, July 31, streaming only on Disney+. New episodes will be released every Friday.

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Disney Plus "Muppets Now" Zoom Video Call With Kermit the Frog And Friends - We Are Movie Geeks

Most Googled things by US states over past 10 years including Kim Kardashian, Baby Shark and Fortnite – The Sun

YOU may not remember what you searched Google for back in 2010 but a new animated map could jog your memory.

V1 Analytics has put together an eye opening YouTube video that shows what each US state has been searching for over the past decade.

7

The last decade started off with over 20 of the 50 US states searching for Selena Gomez.

By the end of January though the singer was competing with searches for 'McDonald's nutrition'.

Searches for Kim Kardashian became popular in Louisiana but this paled in comparison to the amount of searches for Katy Perry by the end of the year.

On 24 of September 2010, over half the US states were searching for Katy Perry, five were searching for "HCG diet" and Louisiana was still looking for Kim K.

7

By January 2011, most US states were either searching for Adele or the Womble dance.

Almost all US states had Adele as their top search at the start of February, the singer released her album 21 at the start of 2011.

She was soon overtaken with searchers for Lady Gaga's 'Born this Way'.

By March and April searches for Rebecca Black exploded after a video she featured in went viral.

Osama Bin Laden's death in May 2011 also took over searches.

Games of Thrones, Kate Upton and Steve Jobs were also top.

Adele remained a very popular search throughout the year.

The start of January 2012 saw almost all the US states searching for "Kindle Fire", while four others searched for "Pinterest".

This was soon overtaken by searches for "Abortion", a search that remained popular throughout the year.

Abortion was being discussed a lot in the US at the time because 2012 saw numerous restrictions on access to abortion services for some states.

The film Fifty Shades Darker was a top search by June.

Nike and Tory Burch were also popular.

7

The start of 2013 saw Gangnam Style takeover.

"Slender Man" and "Thrift Shop" were also popular searches.

By the end of the year "Vine" was a top search along with "Royals".

7

January 2014 saw animated film Frozen completely take over Google Search.

By November searches for the Samsung s5 were very popular, with a few people searching for Meghan Trainor and Sam Smith.

7

This year started off with a boom in searches for singer Meghan Trainor.

By April searches for video game Mortal Kombat X took over.

Hotly anticipated film Jurassic World also became a top search for most states.

Then came searches for Donald Trump and "Pepe the Frog", which still remains a popular meme.

Zika Virus, Ted Cruz and Beyonce were all top searches at the start of 2016.

Then "Damn Daniel" became a trend.

Harambe the gorilla and the Google Pixel also caused mass searches.

This was the year of the song Despacito.

It also saw mass searches for Harvey Weinstein and Kevin Spacey.

7

This year started with mass searches for Fortnite and Logan Paul.

Fortnite was still popular by the end of the year as well as viral song Baby Shark.

7

Searches for R Kelly, Ariana Grande's song 7 Rings and Billie Eilish were all top at the start of 2019.

Game of Throne also took over due to the finale.

By the end of the year Mandalorian and Baby Yoda had taken over.

It probably comes as no surprise that "Coronavirus" has been a top search in almost all states this year.

Netflix series Tiger King has also proved popular, along with Elon Musk, The Weeknd and people simply searching the phrase "Pandemic".

You can see the full video below.

How to view what Google knows about you

You can take the following steps...

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In other news, a major Gmail redesign is aiming to make your working life a lot easier.

Google, Reddit, LinkedIn and TikTok have been caughtspying on your iPhone.

And, scammersare using Google Alertsto send out links to malware.

What's your most common Google search? Let us know in the comments...

We pay for your stories! Do you have a story for The Sun Online Tech & Science team? Email us at tech@the-sun.co.uk

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Most Googled things by US states over past 10 years including Kim Kardashian, Baby Shark and Fortnite - The Sun

Fitness Facts: What does healthy eating really mean? – GCU Today

By Liz CookRegistered Dietitian, Canyon Health and Wellness Clinic

We hear the word healthy thrown around a lot these days. Healthy food, healthy diet, healthy body, healthy mind, healthy lifestyle the list goes on.

But when it comes to healthy eating, what does healthy really mean? How do you know you are buying good-quality food that is good for your body? How do you see through marketing and misconceptions to know what you really should pick? Lets break it down:

First things first. Buying whole, fresh, unprocessed foods is your best bet. Think fresh fruits and veggies, minimally processed meats, whole grains, nuts, seeds and legumes. If it doesnt need a nutrition label, its probably a good thing to buy!

However, plenty of healthy foods come in packages and will contain a Nutrition Facts label. This label has a ton of information on it and can be a little overwhelming.

Fortunately, the labels are getting a makeover, and you will start to see more and more of the new Nutrition Facts labels in the future. The updates make the labels easier to read and understand. If youre interested in seeing a comparison of the two, click here!

When it comes to deciding what to eat, instead of trying to compare every line on the label, focus on a few important pieces.

Things to maximize:

Things to minimize:

Focusing on the Nutrition Facts panel can give you valuable insight into what you are eating, but make sure to check out the ingredients list as well! When it comes to reading an ingredients list, be sure to consider three important factors.

First, shorter lists are more favorable and are usually found on foods that are closer to their naturally occurring form.

Next, the order of ingredients matters. Ingredients are listed in order from most to least, so if sugar is the first ingredient on the list, youre eating mostly sugar! Look for recognizable, whole foods at the top of the list.

Finally, evaluate the complexity of the ingredients. If the words in the ingredients list look more like the names of chemicals than the names of foods, its likely something to avoid.

Evaluating the back panel gives you tons of information, but dont ignore any claims made on the front of the package. In trying to sell products, food companies use different words and phrases that can be misleading at times.

For example, a food labeled as calorie free can contain up to 5 calories per serving. If the serving size is small, you may use multiple servings without realizing it and end up adding calories you may not even realize were there!

The same goes for fat free and sugar free, which really mean less than a half-gram per serving. Here are a few other front-of-label claims to look out for:

Another question that comes up frequently: Is organic produce better than conventional? The answer depends on a few factors.

First, if you have an unlimited budget to buy all organic, go for it! There arent really any downsides to consuming fewer pesticides.

However, if that is not realistic for you, there is a tool to help make the decision a little easier. The Environmental Working Group comes up with a list of the Dirty Dozen each year. This list contains the produce items that have been found to have the highest amount of pesticide residue on them and should be bought organic when possible.

The group also has a list of the Clean Fifteen, or the foods with the least pesticide residue, that you can feel more comfortable buying conventionally. Its also worth noting that organic foods have roughly the same number of calories, carbs, protein, fat, etc., as their conventional counterparts.

One final thing to discuss is the concept of health halos. This is the notion that a food is healthier because of a claim made on the label, a diet it fits into, or the store it was purchased from.

A few examples of this rationale are that all natural foods are better, vegan foods are healthier or anything from Whole Foods is inherently healthy. These are common traps that are easy to slip into, but with the knowledge you have gained from this article you can be a smarter consumer and really pick the best option!

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Fitness Facts: What does healthy eating really mean? - GCU Today

10 reasons to have a primary care physician – Post Register

It is highly recommended that people have a primary care doctor who knows you and your family well. Here are 10 compelling reasons why its important for you and your family to have a primary care doctor (PCP).

Continuity of Care

When an entire family has an ongoing relationship with a primary care doctor, they get a better quality of care. They get to know you and your family over time, and, ultimately, know what is right and wrong for you because they are familiar with your lifestyle, your health, your family, and your medical history.

Health Education

You and your family will receive special attention from a primary care doctor. They are like medical life coaches and take the time to teach healthy lifestyle choices to help you and your family live the best possible lives.

Higher Level of Comfort

A primary care doctor is someone you can always feel comfortable voicing your concerns to and leave an appointment feeling as though you were really listened to. They will help you to become an informed and active member of your healthcare decision-making process.

Preventative Care

A primary care doctor understands preventative care. Like a dentist, they perform annual checkups to uncover any problems. The earlier health abnormalities are detected, the better chance you have at receiving treatments that could result in more favorable outcomes.

Health Management

They provide thorough health evaluations for the entire family from infants to the elderly. These evaluations include well-child visits for immunizations and sports physicals and wellness exams for men and women. These preventative exams can help detect high blood pressure, high cholesterol, heart problems, thyroid issues, diabetes, a variety of cancers, and so much more.

Advocate

A primary care doctor is a reliable and trustworthy resource to help you navigate the complex healthcare system.

Referrals to Other Medical Specialists

An experienced and well-connected primary care doctor will provide qualified assistance in finding the right specialist when required by illness or injury.

Coordination of Care

If a specialist is required, a primary care doctor can coordinate information between other healthcare providers, making sure there is no duplication of testing to help reduce your medical costs.

Better Patient-Doctor Communication

They are your first-line of defense if something is not right. They will take your phone calls and answer any questions you might have about a pressing medical issue. They can assess the urgency of most medical problems and will direct you to the best place for that care.

Longevity

They look at the big picture of you and your familys health. Overall, having a primary care doctor will keep you as healthy as possible as you navigate through the many stages of life. Studies show people who regularly visit a PCP have longer, healthier lives.

In addition to all of those compelling reasons to have a PCP, Binghams PCPs are currently offering Tele-Health visits (online or over the phone) for those individuals that find it difficult to come into the office. In the past three months, weve had over 4,000 Tele-Health visits. And, in case you didnt know, Bingham offers a FREE transportation service that picks up patients from their home, gets them to their appointment, and gets them back home.

Need a Primary Care Physician?

Bingham Healthcare Family Medicine has a growing number of family medicine specialists located throughout eastern Idaho. To find a provider in Blackfoot, Idaho Falls, Shelley, or Pocatello, please visit BinghamMemorial.org/Family-Medicine or call (208) 785-4100.

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Real Men Take Care of Their Wellbeing #ManHoodGame – The Good Men Project

Here are some of the ways you can put your health first and take care of yourself.

July 21, 2020 by Isaiah Ram Leave a Comment

Theres been a certain stigma around the past few generations related to men utilizing resources for their health. Maybe you grew up with a father who thought going to the doctor was not manly. Maybe you have a friend who scoffs at the idea of staying on top of checkups.

Whatever it may be, its important that you set your health as a priority in your life. Here are some of the ways you can put your health first and take care of yourself.

The most important thing you can do today is to focus on living a healthy lifestyle. This means exercising, having a good diet, and taking care of yourself. Everyone knows the saying you are what you eat but few understand the importance a diet can play in your future. Heart disease, muscle atrophy, and even sexual health can be impacted in 20 or 30 years based on the decisions you make today.

So, improve your diet! Its ok to live a little and enjoy pizza for what it is but know that its not sustainable for your health. Vegetables, fruits, and nutrition-dense foods will yield the most return for your body in the long run. There is nothing more manly than a man who takes care of himself by eating clean.

You shouldnt feel shame over your lifestyle, either. Some men face pressure from friends who eat poorly or drink a lot of alcohol to join in on unhealthy behaviors. Sure, drinking a six-pack with the boys every weekend sounds like a great time, but do you realize the impact youre having on your liver? Have you considered how alcohol is impacting your weight? What about developing nerve damage and needing neuropathy treatment? This isnt to scare you or shame you, but real men should be aware of the impact food and alcohol can have on their bodies!

These are important things to consider as you grow into who you are as a man. No one will wish they had drunk more beer or smoked more cigarettes on their death bed at a young age. No one would want to live with neuropathy or heart disease. A day will come when you realize you arent invincible to what you gave yourself to and youll wish you had taken better care of your health.

Many men can recall their fathers never going to the doctor. It couldve been a life-threatening disease, an auto accident injury, or any number of things that could have lifelong effects. As a man, its important that you dont fall victim to this old way of thinking. Its good for you to take care of yourself and see a doctor!

Treating things as soon as possible will negate the long-term effects an incident has on you. Its easy to get into a car accident and think that you dont need to see a car accident chiropractor. Or maybe youve been diagnosed with a condition, and youre not wanting to take time off work so you try and fight through the pain.

This isnt good for you. Your body needs you to mend and take care of it. Dont fret over losing some money or worry about what your friends will think if you visit a doctor after sustaining an injury. Theyll understand when you explain why youre choosing to take care of a problem up front, rather than later. Who knows, it could be too late if choose to wait.

Think youre too young to need a prostate exam or a colonoscopy? Or afraid your friends or wife would judge you for being proactive? The truth is being proactive never hurts anyone. In fact, it could be the thing that saves you from a condition you had no idea about!

Visiting an orthopedic clinic or physician regularly will yield benefits for years to come. Doctors can see and plan for things before they happen. MRIs, CT scans, and other modern technology make it easier to catch things wrong in your body. Why would you not take advantage of this at a young age by continually monitoring your health? For whatever reason, many guys think their health is something they dont need to worry about until theyre older. And thats just not true!

There is no shame in visiting a doctor. Its ok to diet and watch your blood pressure. Youre not strange for considering your health years before most men do. Real men take care of their bodies by dieting, exercising, and being proactive with checkups. Its time that more guys realized what a healthy lifestyle would bring them for years to come.

Photo: Shutterstock

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Real Men Take Care of Their Wellbeing #ManHoodGame - The Good Men Project

The Genius Of The War On Drugs A Deeper Understanding – Guitar.com

Good vibrations

Guitar is my life, yknow? That was Adam Granduciel speaking to Guitar Magazine in 2017, following the release of The War On Drugs fourth album. Coming from one of modern rock musics great restless perfectionists, its no empty hyperbole. A Deeper Understanding is Granduciels magnum opus, a luminescent epic and stunning example of obsessive studio craft that betters its predecessor Lost In The Dream a record which itself drove him to the brink of insanity. Granduciel re-recorded the whole of that 2014 album, his attention to microscopic detail almost destroying the entire project as he disappeared so far down the rabbit hole at one point he was reportedly measuring minute speaker vibrations.

A Deeper Understanding, too, involved hundreds of hours of studio time, revealed in its intricate layers of vintage guitars, organs and synths, meandering multi-part solos and dreamy sonics.

While the Philadelphia band is essentially Granduciels project, hes surrounded by an evolving cast of stellar musicians and their major label debut started to emerge while they toured Lost In The Dream. Returning from the tour, the now 41-year-old moved to Los Angeles. The cross-country relocation brought a laser-guided focus to the sessions, the band flying in from the East Coast for a week at a time. Granduciel told Guitar Magazine in 2017: I knew I only had em for a week and I wanted to squeeze everything into that week rehearsal, writing, friendship, barbecues so we did it all at the studio we barbecued at the studio!

The songs themselves are exhilarating widescreen American road trip anthems, indebted to Springsteen, Dylan and Petty and the modulated sonics of the 80s, canyon-deep reverb soaking Granduciels soaring guitar solos. In the hands of a lesser musician, they could drift into the realms of cloying AOR, but Granduciels visionary attention to detail wins out. I spend six, seven, eight months on the same song, he explained to Guitar Magazine. I have all these different melodies going on in the song, and you want to highlight each of them, so its trying to sculpt this thing where, if you put everything in, it would just be a wash, so youre trying to paint this picture, but keep all your favourite elements in.

Of the many guitar highlights on A Deeper Understanding, perhaps the most thrilling arrives as early as the second track, Pain. The song is built around a simple C-E-D progression, which Granduciel plays with a capo at the third fret. It unfurls steadily from a lilting arpeggio, the singer recalling wistfully, I met a man with a broken back/ he had a fear in his eyes that I could understand before he winds up for an epic two-part pentatonic solo that epitomises the War On Drugs celestial appeal. Do yourself a favour and look up one of the online lessons, its a joy to play.

Strangest Thing, Granduciel gazing up at a sky painted in a wash of indigo, houses equally hair-raising guitar moments, including a huge solo and wailing Bigbsy bends that flirt continuously with toppling over the edge into untamed feedback. Granduciels playing never resorts to nebulous, self-fellating noodling, though. The solos on A Deeper Understanding are emotive thunderbolts executed tastefully. Nor is he just an old-fashioned guitar hero.

Granduciels Dylan-like lyricism is poetically evocative throughout A Deeper Understanding. On the more sedate Knocked Down, shrouded in great angular shards of guitar noise and waves of tremolo, he sings enigmatically: Sometimes I can make it rain, diamonds in the night sky/ Im like a child. The albums first single, Nothing To Find, is a freewheeling cousin of Lost In The Dreams supreme lead single Red Eyes, its wailing harmonica and chiming Johnny Marr-like arpeggios propelling a glorious, lovelorn anthem.

Image: Mark Horton / Getty Images

Thinking Of A Place, meanwhile, stretches from its lilting slide guitar opening to 11 minutes, none of them excessive, images of the Missouri river and moonlit beaches flickering in and out of focus. At its mid-point the song breaks down to Granduciel speak-singing hazily, Once I had a dream I was falling from the sky/ Comin down like running water/ Passing by myself alight. Its a sumptuous piece of writing.

The vast, layered sound that cloaks A Deeper Understandings dreamy evocations of endless desert skies and vanishing-point roads is powered by a suitably tasteful array of guitars. Alongside Prophet 6 and Arp Odyssey synths, a Baldwin organ and Wurlitzer electric piano, Granduciel uses a 72 Gibson Les Paul Deluxe, a 1980s Japanese Squier Strat, a stunning Gretsch White Falcon, a 66 Gibson SG, a 66 non reverse Firebird and his current live favourite, the most expressive guitar Ive ever played, an American Vintage 65 sunburst Fender Jazzmaster. In the middle position that Jazzmaster, with a chorus pedal its like the brightest, most crystalline thing, Granduciel told us back in 2017.

Trusted effects include an Electro-Harmonix Stereo Memory Man, a Mu-Tron phaser, DigiTech HardWire delay and reverb, a Strymon Flint tremolo and reverb and a Fulltone OCD.

David Hartley of The War On Drugs. Image: Anthony Pidgeon / Redferns

It all amounts to one of the best live guitar sounds youll hear anywhere, and A Deeper Understanding is a scintillating distillation, painstakingly constructed by one of the modern eras most proficient craftsmen. Its a record Granduciel says is about watching yourself move between different versions of yourself and trying to either hold onto or figure out which one youre more comfortable being.

Uncut editor Michael Bonner described A Deeper Understanding as some of the richest, most compelling and least lonely-sounding music of Granduciels career. Laura Snapes wrote in The Guardian of an arcing, shivery slow dance that seems to swirl around a disco ball the size of the moon, while NME described a vision of 80s pop-rock warped through the prism of second-wave shoegaze.

The album topped many critics end-of-year lists and landed the coveted Best Rock Album award at the 2017 Grammys. Adam Granduciels torturous perfectionism had been rewarded. A Deeper Understanding is a masterpiece.

Image: Rich Fury / Getty Images for Coachella

The War On Drugs, A Deeper Understanding (Atlantic, August 2017)

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The ‘Business of Drugs’ is a business you need to see – We Are The Mighty

Looking for a great show to watch that will challenge the way you look at things?

Netflix has just released "The Business of Drugs," a documentary series that goes deep within the drug trade around the world. Now, I know what you are thinking: You have seen "Narcos," Narcos Mexico," "Cocaine Cowboys" and other shows and documentaries on the illicit drug trade.

Created by U.S. Navy SEAL and Executive Producer Kaj Larsen, and hosted by former CIA Officer Amaryllis Fox, the series will examine the illicit drug trade from around the world to here at home.

The series looks deep into the drug trade from where they originate and the pathways that are used to get them to their final destination. The Business of Drugs will trace the path of cocaine, heroin, methamphetamines, marijuana, and various other drugs and will reveal the business, violence and fallout along the way.

The series will also look at both the economics of drug trafficking and the economic impact of the trade.

Who makes the money and who loses big in a multi-billion dollar global enterprise?

Larsen hopes that by understanding narcotrafficking through the lens of business, the series will show that modern drug cartels operate as highly organized multinational corporations.

Fox embeds with traffickers in Colombia, DEA agents in Chicago, mules in Kenya and consumers right here in the States - in Los Angeles - and tells us the human story of a multi-billion dollar criminal industry. The former spy uses her formidable intelligence-gathering skills to finally expose the economics of exploitation and power that fuel the global war on drugs and who it affects.

Did you know:

Despite studies showing that Black and white Americans use drugs at the same rate, convictions rates and sentencing lengths for Blacks is substantially higher. Republican Senator from Kentucky, Rand Paul, even referenced this when he spoke out against mandatory minimum sentences for drug offenses.

This documentary is especially poignant now while Americans take a hard look at how the law is enforced among us. We learn that the War on Drugs is the single largest factor in the incarceration of

Black and brown people in the United States. Prosecuted as a strategic tool by governments and security services for over 30 years, the War on Drugs has put more people of color in prison than any other single policy.

"The Business of Drugs" brings these policies to our attention and makes us question if the "War" we are fighting is actually working or if we are wasting taxpayers' money, costing lives and making things worse. Watch the series and decide for yourself.

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How a miracle drug changed the fight against infection during World War II – The Union Leader

In March 1942, 33-year-old Anne Miller lay delirious in New Haven Hospital, deathly ill from septicemia that she developed following a miscarriage a month before. During her stay at the Connecticut hospital, doctors tried every cure imaginable from sulfa drugs to blood transfusions as her temperature at times spiked past 106 degrees.

She was just incurable, Eric Lax, author of The Mold in Dr. Floreys Coat, said in a phone interview. It was like somebody today with COVID-19 who is going down the tubes.

Desperate, her doctors acquired a tablespoon of an experimental drug and gave her an injection. Overnight, her temperature dropped. A day later, she was up and eating again.

The miracle drug that saved her life? A virtually unknown substance called penicillin.

As researchers around the world chase a vaccine and treatments for the novel coronavirus, the quest echoes the race to mass-produce penicillin in the United States and Britain during World War II.

In the days before antibiotics, something as simple as a scratch or even a blister could get infected and lead to death. Before the beginning of the 20th century, the average life expectancy was 47 years, even in the industrialized world, according to the National Institutes of Health. Infectious diseases such as smallpox, cholera, diphtheria and pneumonia cut life short. No treatment existed for them.

Scottish biologist Alexander Fleming had discovered the penicillin mold in London in 1928. Fleming attempted to extract the molds active substance that fought bacteria but was unsuccessful, and he gave up experimentation, according to Laxs book.

As war broke out in Europe in 1939, Australian doctor Howard Florey obtained funding from the Rockefeller Foundation in New York to study Flemings discovery further at the University of Oxford. Along with brash German emigre Ernst Chain, and meticulous assistant Norman Heatley, he worked to generate penicillins active ingredient.

But in the course of their research, Florey confronted an obstacle: Extracting the active ingredient from the mold was terribly difficult. Time after time, the delicate mold would dissolve in the process of extraction, leaving scientists frustrated.

The tablespoon of penicillin that cured Anne Miller represented half the entire amount of the antibiotic available in the United States in 1942. To give her a full treatment, doctors had to collect her urine, extract the remaining penicillin from it at about 70% potency, and re-inject it, according to Laxs book.

Through trial and error, the team had discovered that penicillin was much more effective and safer in fighting bacteria in animals than sulfa drugs, which were the treatment for infections at the time. Discovered by German scientists in the 1930s, sulfa drugs had severe side effects, and researchers were motivated to find an alternative.

As they tried to cultivate penicillin, they began a few human tests. In late summer 1940, Albert Alexander, a 43-year-old Oxford police officer, scratched his face while working in his rose garden. The scratch became infected by streptococci and staphylococci and spread to his eyes and scalp, according to The Mold in Dr. Floreys Coat. A few weeks later, he was admitted to an Oxford University hospital.

Lax writes that Alexander was in great pain and desperately and pathetically ill for months as he lay in the hospital with no cure available. The abscesses on his face and arms were oozing pus everywhere, Heatley wrote in his diary, Lax notes, and Alexanders left eye became so infected that in February 1941 it had to be removed.

The bacteria continued eating at him and soon spread to his lungs and shoulders. Desperate, doctors gave him 200 milligrams of penicillin, the largest individual dose ever given at the time, and then three doses of 100 mg every three hours, according to Lax. Within 24 hours, there was a dramatic improvement, Heatley wrote.

Alexanders fever went back to normal and his appetite returned. As with Anne Miller, researchers collected his urine to extract penicillin to re-administer.

By the end of February, Alexanders treatment had used up the nations entire supply of penicillin, according to Lax. After 10 days of stability, his condition deteriorated without any more of the drug. A second course would have helped him to fully heal, but there was no more to give him. Florey and the others watched helplessly as a flood of septicemia swept through him. On March 15, he died, Lax writes.

Heartbroken, Florey, Chain and Heatley continued to hunt for methods to produce more penicillin. Meanwhile, the Battle of Britain raged around them. In fall 1940, 50 million pounds of bombs were dropped on London alone, Lax writes.

The Oxford team realized penicillins urgent value in treating wounded soldiers and civilians.

They knew that of the 10 million soldiers killed in World War I, about half died not from bombs or shrapnel or bullets or gas but rather from untreatable infections from often relatively minor wounds and injuries, Lax said.

As Europe sank deeper into war, labs around the world got word of the Oxford labs penicillin research and began requesting samples. Florey and his team were careful not to send any to German scientists, who could have easily developed them to support the Nazi war effort, according to Lax.

The Oxford team was so fearful of the drug falling into Nazi hands that as the Blitz bombings shattered England, the team rubbed their coats with the mold, knowing the spores would live for a long time on fabric, Lax said in a phone interview. That way, if any researchers were captured or had to travel in a hurry, they had it with them and could extract and regrow it.

British pharmaceutical companies were interested in mass-producing penicillin, but they were overburdened by wartime demand for other drugs. Florey and Heatley began looking overseas for help, turning once again to the Rockefeller Foundation in New York.

Florey struck a deal with his Rockefeller contacts: He and Heatley would show Americans how to produce penicillin molds. In return, Americans would give Florey a kilo of the drug. This would provide the Oxford researchers with enough penicillin to complete human trials for suffering patients like Alexander. The foundation agreed.

In a hazardous trip out of war-torn Europe, Florey and Heatley arrived in New York on July 2, 1941.

Through Rockefeller contacts, Florey had access to major players in the U.S. government to back his project including the War Production Board and the U.S. Department of Agriculture. A week after arriving in New Haven, Heatley and Florey traveled to the USDAs Northern Regional Research Laboratory in Peoria, Ill., a farming community about 160 miles southwest of Chicago.

Robert Coghill, the head of the fermentation division, agreed to help the Oxford cause if Heatley would stay on in Peoria to get the penicillin mold culture started. Leaving Heatley in Peoria, Florey visited U.S. drug companies in the hope of persuading one or more of them to brew the culture fluid and extract the mold to yield enough for his experiments, according to The Mold on Dr. Floreys Coat.

By the fall, Florey had persuaded Charles Pfizer & Co., Eli Lilly & Co., Merck and other drug firms to work on the project, and he returned to Oxford to wait for his kilo of penicillin. But then war struck the United States. With millions of American lives now at stake, penicillin was no longer just a scientific fascination to U.S. pharmaceutical companies it was a medical necessity.

Ten days after the Pearl Harbor attack, pharmaceutical companies began escalating penicillin production for the war effort, some experimenting with a process called deep-tank fermentation to extract the drug from the mold. It was a major breakthrough.

As war escalated throughout 1942, researcher Andrew Moyer led the USDA Peoria lab in finding the most potent penicillin mold that would hold up during fermentation extraction. Each day, he sent assistant Mary Hunt to local markets for decaying fruit or anything with fungal growth to find more-productive strains of the penicillin mold, Lax writes. Earning the nickname Moldy Mary, she once found a cantaloupe with a mold so powerful that in time it became the ancestor of most of the penicillin produced in the world, according to the American Chemical Society.

In July 1943, the War Production Board made plans for widespread distribution of penicillin stocks to Allied troops fighting in Europe. Then scientists worked round-the-clock to prepare for an ultimate goal: having enough to support the D-Day invasion.

On June 6, 1944, 73,000 U.S. troops landed on the beaches of Normandy, boosted by millions of doses of the miracle drug.

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How a miracle drug changed the fight against infection during World War II - The Union Leader

Breaking News – Four-Part Docuseries "The Last Narc" Premieres July 31 Exclusively on Amazon Prime Video – The Futon Critic

FOUR-PART DOCUSERIES THE LAST NARC PREMIERES JULY 31EXCLUSIVELY ON AMAZON PRIME VIDEO

Featuring interviews with government and cartel insiders, the series unpacks the shocking political conspiracy surrounding the kidnapping and murder of DEA Agent Enrique "Kiki" Camarena

CULVER CITY, Calif. - July 21, 2020 - The Last Narc, a provocative four-part docuseries that centers on the most notorious murder in the history of the DEA - the 1985 kidnapping and murder of DEA Agent Enrique "Kiki" Camarena - will premiere July 31, 2020 exclusively on Prime Video in more than 200 countries and territories worldwide.

The series tells the story of a fallen hero, the men who killed him, and the one man who risked everything to find out what really happened and why. Highly decorated special agent Hector Berrellez, who was assigned to lead the DEA's investigation of Camarena's murder, peels back the layers of myth and propaganda to reveal the bone-chilling truth about a conspiracy that stretches from the killing fields of Mexico to the halls of power in Washington, D.C.

Berrellez's powerful testimony appears alongside that of Camarena's brave widow, as well as three Guadalajara Cartel insiders. These men were corrupt Jalisco State policemen who, at the time of Camarena's murder, served as bodyguards to legendary drug lords Rafael Caro Quintero and Ernesto Fonseca Carrillo. Eventually, they became informants for Berrellez and helped him crack the most infamous murder of the War on Drugs.

The Last Narc is directed by Tiller Russell and a production of Amazon Studios and Industrial Media's The Intellectual Property Corporation (IPC). IPC's Eli Holzman and Aaron Saidman are executive producers.

Over the course of his career, Russell has explored a variety of true crime cases across his documentary and fiction work including: Operation Odessa, which premiered at South by Southwest Film Festival and was released by Showtime; The Seven Five, which premiered at DOC NYC and was released by Sundance Selects; and the upcoming Silk Road, which stars Jason Clarke and Nick Robinson.

Prime members will be able to stream The Last Narc exclusively via the Prime Video app for TVs, connected devices including Fire TV, mobile devices and online. Members can also download the series to mobile devices for offline viewing at no additional cost to their membership. The series will be a global release and available on PrimeVideo.com for Prime Video members in more than 200 countries and territories.

Customers who are not already Prime members can sign up for a free trial at http://www.amazon.com/prime. For a list of all Prime Video compatible devices, visit http://www.amazon.com/howtostream.

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Breaking News - Four-Part Docuseries "The Last Narc" Premieres July 31 Exclusively on Amazon Prime Video - The Futon Critic

As Philippines fights coronavirus, some fear involvement of the police – Reuters

MANILA (Reuters) - At the peak of the Philippines war on drugs, people in the rundown neighbourhoods of Navotas in the capital Manila grew used to police knocking on doors, or bursting into the homes of drug suspects - who often wound up dead.

Children look out from a window of their shanty home while a police officer on board an armored vehicle patrols the neighborhood to enforce the reimposed lockdown amid a spike in the coronavirus disease (COVID-19) cases, in Navotas, Metro Manila, Philippines, July 17, 2020. REUTERS/Eloisa Lopez

Now, many residents of the Navotas area, which has been particularly badly hit by the coronavirus, fear another harsh police campaign after the government said officials will visit homes of patients with mild or no symptoms and escort them to isolation centres.

Some Filipinos have labelled the plan Tokhang 2, calling it the sequel to a police-led anti-drug campaign that became synonymous with thousands of killings.

We are afraid of the house-to-house. We dont know what the police and soldiers will do to us, said Crisanto dela Cruz, a 46-year-old pedicab driver in Navotas.

At the same time, we are afraid of getting infected because we are always outside.

Infections have tripled in the Philippines since June 1 and the interior ministry announced this week that health officials, with the help of local authorities and the police, will move people suffering from COVID-19 from their homes to isolation centres. It has urged neighbours to report potential cases of infected people who are evading authorities.

President Rodrigo Dutertes spokesman, Harry Roque, stressed the home visits will be led by local health workers.

In a statement, he said police presence is merely to provide support or assistance in the transport of patients.

But Roque also said anyone likely to spread the virus could be forcibly removed if need be.

We can still compel them but I dont think it will be in the nature as if they are being treated as criminals, he told CNN Philippines.

The United Nations has said at least 8,663 people, and possibly many more, were killed in the Philippines after Duterte launched a war on drugs in 2016. It said the killings took place amid near impunity for police and incitement to violence by top officials.

Most of the deaths were in poor, run-down areas like those in Navotas.

Police say their actions in the anti-drug campaign have been lawful and that deaths occurred in shootouts with dealers resisting arrest.

The coronavirus strategy was announced in a week when the Philippines recorded Southeast Asias biggest daily jump in deaths from the disease.

While much of East Asia appears to have COVID-19 under control, the Philippines has recorded nearly 36% of its infections and 23% of its 1,660 deaths in the past two weeks. In the region, only Indonesias death toll is climbing faster.

The government has defended the house-to-house approach, saying that infected people with insufficient space to quarantine themselves at home should be moved to isolation centres.

But opposition senators and human rights groups say the campaign is from the playbook of the drug war.

Senator Franklin Drilon said police had been enforcing a lockdown aggressively, and there was no need for fascist actions to demand submission.

The National Union of Peoples Lawyers called it another tool to sow fear in our communities.

With a government that has emboldened its own uniformed personnel to violate human rights with impunity, how can we be sure that the police will not abuse this new power, it said.

A better approach, say critics, is to improve contact-tracing and testing, with just 0.9% of the population tested so far. Roughly two-thirds of the tests followed the relaxation of restrictions on June 1 to try to rescue the economy.

Navotas has since seen cases grow from 286 at end May to 906 as of July 16, prompting authorities to reimpose restrictions, with armed police in camouflage deployed to keep people indoors and threaten violators with fines.

Its not martial law, theres no need for police to go house-to-house, said Arvin Provito, a Navotas tricycle driver.

What they should do is do house-to-house testing.

Former health minister Esperanza Cabral said the government should rethink its approach.

As they say, give a carpenter a hammer and all he will see are nails, she said. As for the people, theyve been so used to being treated as nails theyre naturally scared of anyone who has a hammer.

Additional reporting by Adrian Portugal, Eloisa Lopez and Neil Jerome Morales; Editing by Martin Petty and Raju Gopalakrishnan

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As Philippines fights coronavirus, some fear involvement of the police - Reuters

Pressure from Manipur CM Biren Singh to drop drugs case: cop to court – The Indian Express

Written by Esha Roy | New Delhi | Updated: July 17, 2020 4:57:22 am Chief Minister Biren Singh, Additional SP (Narcotics) Thounaojam Brinda.

Manipur Chief Minister N Biren Singh and a top state BJP leader have been accused by a senior officer of the state Narcotics and Affairs of Border Bureau (NAB) of allegedly putting pressuring on the department to drop the case against a person accused in a drug seizure raid which took place in June 2018.

The accusation come in the form of a sworn affidavit Additional Superintendent of Police, NAB, Thounaojam Brinda filed in Imphal High Court on July 13.

The police have put the value of confiscated illegal narcotics and cash at more than Rs 28 crore.

The prime accused in the case, Lhukhosei Zou, was considered kingpin of the drugs cartel and was also a local BJP leader in Chandel district, according to Brindas affidavit.

When contacted by The Indian Express, Chief Minister Biren Singh said, The matter is sub judice. It would not be legally proper to comment. But it is known to everyone that no person can interfere in any judicial proceedings or court cases; the law takes its own course to meet the ends of justice.

He said, For our government, the war on drugs will continue, and no party involved whether a friend or a relative would be spared in the campaign

According to Brindas affidavit, the controversy revolves around a raid carried out across Imphal by NAB teams under her, and subsequent arrests of eight people allegedly found in possession of illicit drugs and cash, on the intervening night of June 19-20, 2018. They were booked under different IPC Sections and the Narcotic Drugs and Psychotropic Substances Act, 1985.

According to police, 4,595 kg heroin, over 2.8 lakh World is Yours (WY) amphetamine tablets weighing 28 kg and other items were seized during the raids. Altogether the total seized amount of drugs along with the seized currency was Rs 28,36,68,000 at international market, the police have said.

According to Brinda, Zous arrest became sensational given his political position and strong community base in the border town area of Moreh. At the time of arrest, he was chairman of the 5th Autonomous District Council of Chandel district, the affidavit states. He was elected to the Autonomous District Council (ADC) in June 2015 on a Congress ticket.

In September 2015, he became chairman of ADC Chandel district and later joined the BJP in April 2017, it says.

Brinda said that since the arrest, both she and her department have been under pressure to drop the case against Zou.

On the raids, Brinda told The Indian Express: One of the accused we had arrested earlier that evening told us that there were drugs with Zous driver. When we went looking for him, he (Zou) said his driver was in Guwahati. He refused to let us search his house. We nabbed the driver nevertheless after extensive searches that evening he informed us that there were drugs at Zous residence. When we went back, Zou refused to let us search. There was a scuffle between NAB boys and his men. We finally searched his home (and) found the drugs.

In March 2019, Zou received bail, which he jumped and fled across the border to Myanmar. He surrendered in February this year and his bail hearing came up before Imphal HC, where the judge held that everyone is innocent until proven guilty.

Brinda filed a complaint against the judge with the Registrar of Imphal High Court last month. Subsequently, after lashing out at the judge in a social media post, Brinda was served a contempt notice this month. She filed this affidavit in response on July 13.

This was a big drug haul for the NAB and was a result of a recent raid in Jowai in Meghalaya where a large amount of WY tablets were seized, Brinda, who joined NAB in March 2018, just three months before the raid, stated. The Meghalaya accused pointed to the accused in Manipur who were a part of the same cartel. The war on drugs that the government talks about was actually revived in 2018. Over the past few years, the drug route from Afghanistan-Pakistan had dwindled and instead had shifted to the Manipur-Myanmar border. Indian drug lords now prefer this route and huge consignments of drugs are flooding the market and makes its way across the country all the way down to Kerala even.

This is what we are trying to curtail. All the hill districts are covered with poppy plantations, and yet the government of Manipur, for the past 30 years, doesnt even have data on how much area is covered by poppy growing.

A Manipur state police service officer of 2012 batch, Brinda was conferred the states Police Medal for Gallantry by the state government for her work against smuggling and sale of drugs. The Chief Minister awarded Rs 10 lakh to the NAB team for the seizure of Rs 100 crore worth of drugs, one of the biggest hauls in Manipur.

Earlier, Brindas appointment had been put on hold by the previous Congress government on grounds that she is daughter-in-law of Rajkumar Meghan, former chairman of the United National Liberation Front (UNLF), one of the Northeasts biggest insurgent outfits. The state government allowed her to join the police force after Brinda approached the Guahati High Court but resigned in 2016.

After the BJP formed its first government in the Northeast in 2017, Brinda was reinstated in the police force at the behest of the Centre.

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Pressure from Manipur CM Biren Singh to drop drugs case: cop to court - The Indian Express

The People: bridging distance and differences in a pandemic – The Fulcrum

After organizing the Voters Not Politicians 2018 ballot initiative that put citizens in charge of drawing Michigan's legislative maps, Fahey became founding executive director of The People, which is forming statewide networks to promote government accountability. She interviews colleagues in the world of democracy reform each month for our Opinion section.

David Valente got involved in politics helping with a state Senate race in New Mexico when he was a teenager. He has since become discouraged by both major parties' spending and is currently chairman of the West Virginia Libertarian Party. He supports criminal justice reform, protecting civil liberties and ending the "war on drugs."

Sonia Riley served as field director for Cathy Albro, the unsuccessful 2018 Democratic candidate in Michigan's heavily gerrymandered 3rd congressional district, where she observed the effect of a lack of public resources on both urban and rural communities. Now she's running for city council in Wyoming, a suburb of Grand Rapids, advocating for increased voting access and improved health care.

Our recent conversation has been edited for clarity and brevity.

Fahey: It seems you both reached a certain point where you decided to get actively involved in making change. Talk about the moment or motivation that led you to take action?

Valente: I got involved in my first campaign at 16 and built a community with the people on the campaign. It was fun and felt like we were doing something good. In my experience, you can't get anything done if you don't work together, because then you're just a debate club. If you're willing to work together, you're able to influence policy and move the ball forward.

Riley: When I was on the congressional campaign two years ago, it was so significant how black and brown people were often not invited to be part of the conversation. My "Aha!" moment came during the choosing of a location for a watch party. I told the room I was not comfortable going there, and that was an educational moment for a lot of others. If there's no inclusivity at the table, neither party represents my people. If we're not involved and we're not vocal, it hinders the growth of all people. So I fight those injustices, and joining The People has made it even more profound.

Fahey: How have your lives been altered by the coronavirus crisis?

Valente: There are ballot access issues across the country. There are states like Oklahoma where we would have to get 100,000 signatures to get someone on the ballot, and you can't get signatures in this environment. We're finding innovative ways to get the message out, like Facebook and Zoom. We have a gubernatorial candidate who is hosting Zoom meetings every Sunday and interviewing a local policymaker, or highlighting people who are not Libertarian but are still supporting her.

Riley: To run for city council I needed 25 signatures and I collected 50 but 27 were thrown out. I was supposed to be able to pay a $100 filing fee instead, but the city refused. It was an injustice for them to make an immunocompromised person like me go and get signatures, and for people to have to risk their lives to sign so their voices could be heard. I got a call from my party saying they were going to help me fight this. Because of my situation, they've changed the process.

Fahey: At The People, you've created Community Hour, video chats where people can touch base and maybe talk a little about democracy reform. What made you want to start this?

Riley: It's human nature to want to feel connected, and right now every system of connection we have has changed how we're connected with our families, our work, our communities. It's important to have a platform where we can maintain a human connection, and Community Hour creates a way to come together and check in.

Valente: We've talked a lot about how to stay connected when forced to stay apart. I was taking part in "Skype-togethers" with people in my community, and afterwards I felt so much better. I connected in a personal way with people I hadn't seen in ages. So when we were talking about ideas on how to stay connected, that model popped into my head. No agenda, just finding out how others are doing.

Fahey: Have any moments during the calls stood out to you?

Valente: For me, it has been just having great conversations with people I hadn't met before as well as seeing a niece for the first time. No matter what's going on, I think there's a lot of value in these calls.

Riley: I had a profound conversation about grief and loss. People aren't talking about these emotions and acknowledging these feelings. These conversations give space to be authentic and unafraid of judgment.

Fahey: Who is invited to the calls and how can they join?

Riley: All are welcome to join every Wednesday evening 8 Eastern, 7 Central, 5 Pacific. We use Zoom so you can join through video or call in by phone. Details can be found on our Facebook event page.

Fahey: If you were speaking to a high school student or a new immigrant to this country, how would you describe what being an American means to you?

Riley: We as people in brown communities still have to fight to be fully viewed as citizens. For a new person, know the fight will be hard but worth winning in the end. Channel your frustration toward something positive to make a difference. We have a privilege to be in a country saturated in resources. It's a blessing, but it doesn't come without a fight, and it's definitely not for the faint of heart. We have shown resilience as a country, even if our leaders aren't leading to the extent we would like.

Valente: I don't approach this from a nationalistic standpoint. We're all human beings. There's a whole lot of work that needs to be done in this country, and we have to be vigilant in maintaining our freedoms and working to extend them. We're not perfect and we need to make sure we continuously improve and work as best we can toward an ideal society.

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The People: bridging distance and differences in a pandemic - The Fulcrum

Protests, Violence, and MafiasHow the Coronavirus Has Impacted Conflicts Across the Globe – Foreign Policy

A federal officer pepper sprays a protester in front of the Mark O. Hatfield U.S. Courthouse in Portland, Oregon, on July 20.Nathan Howard/Getty Images

As the coronavirus pandemic has disrupted political and economic systems around the world, it has also changed the nature of disordergroup dynamics including political violence and protests. Since the start of the outbreak, the Armed Conflict Location & Event Data Project has monitored the impact of COVID-19 on global disorder, looking at the ways in which demonstrations, state repression, and mob violence have shifted amid the pandemic. As countries begin to reopen, some shifts may hold. In places where democratic backsliding occurred, for example, leaders will likely capitalize on newly won emergency powers to further stifle opposition. Others may mutate and evolvealthough demonstrations precipitously declined after the introduction of movement restrictions, theyre now bouncing back to pre-pandemic levels and, in many areas, are returning with even more force.

As the virus spread and governments imposed movement restrictions, many of the large-scale social movements of 2019 came to a halt, including the October Revolution in Iraq; the Hirak Movement in Algeria; opposition to the Citizenship Amendment Act in India; and the student movement in Chile, as can be seen in the graph below. In a number of cases, local populations turned to new forms of protest to make their voices heard while respecting social distancing guidelines. These included pot-banging protests in Brazil, balcony protests in Spain, and car protests in South Korea.

Although COVID-19 tamped down many existing social movements, government pandemic responses sparked new ones. In Mexico, there has been a rise in protests involving health care workers demanding better access to personal protective equipment. In Iran, anti-government demonstrations continued in response to widespread corruption, poor service delivery, and economic hardshipall exacerbated by the pandemic.

Many of the protest movements that emerged prior to the pandemic were motivated by mistrust of governments seen as corrupt, poor economic managers, and providing subpar governance. In places where state responses to the health crisis have failed or fallen short, governments have only exacerbated these existing grievances, increasing the likelihood that these movements will resurface as soon as restrictions are lifted.

The successful and large-scale rise of the global Black Lives Matter protests is a case in point. The protests have gained traction globally in part because of how the coronavirus crisis has highlighted systemic racial disparities (A common rally sign reads: Racism is a pandemic), leaving clear winners and losers in its path. Other movements are restarting amid similar tensions over government shortcomings during the health crisis. In Tunisia, there are more demonstrations now than prior to the pandemic, with people taking to the streets over the worst economic crisis in decades. In Lebanon, too, previous discontent with the governments response to economic collapse has resurged. Unlike the predominantly peaceful protests seen prior to the pandemic, many of these demonstrations have been violent.

While exceptional state of emergency legislation may be considered appropriate to protect citizens during crisis situationsand may even be met with initial public supportthere is a risk that such laws will be used to suppress opposition and popular mobilization, especially when there is no end to the measures in sight. States of emergency can provide cover to governmentsand especially authoritarian regimesto engage in higher levels of human rights violations, leading to a rise in violence targeting civilians.

Such power grabs have been far from rare during the COVID-19 pandemic. In Hungary, Prime Minister Viktor Orban was bestowed the power to rule by decree with no stated end date; this new power was followed with arbitrary arrests of opponents and restrictions on the press. In Egypt, President Abdel Fattah al-Sisi moved to shore up his position by cracking down on the media and ratifying new amendments granting him sweeping authoritiesthe majority of which have no clear ties to public health issues. In Venezuela, the quarantine offered an opportunity for the Nicols Maduro regime to target the opposition and arrest allies of opposition leader Juan Guaid (who is viewed by scores of countries as Venezuelas rightful ruler). In Guinea, the coronavirus outbreak allowed the regime to silence protests and arrest opposition leaders, enact constitutional changes, and elect and install a new parliament. Across West Africa more broadly, governments are subtly exploiting the crisis to repress opposition and manipulate elections.

In many cases, rising state repression took the form of direct violence against civilians as governments became more likely to suppress their citizens and crack down on opposition and minority groups, often under the guise of lockdown measures. A spike in civilian targeting was reported in multiple countries across Africa, including Uganda (as can be seen in the graph below), Nigeria, and South Africa. In the Philippines, the threat of lethal enforcement of lockdown measures kept many at home, initially resulting in a drop in crimes against civilians related to the states notorious war on drugs. However, in recent weeks, reports of violence against civilians have neared pre-pandemic levels in the country, and they show few signs of slowing as the government moves forward with a new Anti-Terrorism Act that expands the states capacity for warrantless arrests and detention. In Hong Kong, new legislation around a national security lawpassed after demonstrations against plans to allow extradition to mainland China began to resumeraises the risk that Hong Kong residents will face arbitrary detention and unfair trial.

Despite widespread hope that the pandemic would bring the worlds warring parties to the negotiating table, it was unlikely that COVID-19, as a health crisis, would directly impact conflict patterns. Nearly four months after the U.N. secretary-generals call for a cease-fire to all conflicts, the data shows as much: Most warring parties have either refused to declare a cease-fire (as in Myanmar, where the military rejected calls for a cease-fire) or failed at cease-fire attempts (as in the Philippines, where both the Philippine government and the New Peoples Army each announced a unilateral cease-fire, yet violence continued, as can be seen in the graph below).

Although government resources are undoubtedly spread thin by the pandemic, conflicts involving state forces continue to rage. Despite mounting cases of COVID-19 in India, for example, state forces remain engaged on multiple fronts, from Kashmir to the Red Corridor, and more recently along the Line of Actual Control with China. Turkish forces, meanwhile, have intensified their operations against the Kurdistan Workers Party (PKK), launching new operations against the group in June. In Myanmar, the military ramped up its campaign of airstrikes and shelling against rebel groups in Rakhine and Shan states. In Libya, fighting between the Khalifa Haftar-led Libyan National Army and the Turkish-backed Government of National Accord escalated. In Yemen, fighting between Houthi and anti-Houthi forces continued, despite the declaration of a cease-fire.

Some nonstate actors, meanwhile, took the opportunity to scale up their activity against state forcesexpanding their active territories and consolidating their positions. The Islamic State encouraged its fighters early on to carry out attacks against the groups opponents, in order to capitalize on the fact that they would be struggling to manage the ongoing crisis. In Mozambique, Islamist militants (many with ties to the Islamic State) stepped up attacks against civilians and armed forces in the northeastern Cabo Delgado province, with insurgency activity there tripling. In Somalia, al-Shabab continued to launch daily attacks, hindering humanitarian aid. In Mali, the jihadi group JNIM continued its attacks on state forces after announcing that COVID-19 was a God-sent soldier that was weakening the Malian Armed Forces. In Afghanistan, the Taliban continued their battles with Afghan forces to further exhaust Kabuls limited resourcesknowing this could result in increased concessions during negotiations. In Mexico, with state forces preoccupied with the public health emergency, cartels seized the moment to intensify their turf wars and expand to new territories, resulting in a spike in attacks on state forces (as can be seen in the map below).

Cartel Violence in Mexico Since WHO Pandemic Announcement

Alongside wearing down state forces on the battlefield, nonstate actors have also tried to vie for greater legitimacy with local populations, especially in contexts where the government has failed to provide necessities. For example, the Taliban in Afghanistan vowed to cease fighting in areas they control if those areas were hit with the virus so that health workers [could] deliver assistance to that area. The Taliban also held workshops on preventing the spread of the virus and distributed personal protective equipment. Mexican cartels likewise imposed curfews and distributed food to local populationsa tactic they have long employed to establish their support among marginalized communities. The gangs in the Northern Trianglealso known as marashave enforced curfews and suspended extortion collections as a so-called relief effort.

Simultaneously, competition among nonstate actors has risen in certain areas. In Africa, intergroup clashes rose by an average rate of 25 percent. In Mexico, the fragmentation of cartels has led to an increase in criminal violence in recent years, stemming from heightened competition among splinter groups over existing drug trade infrastructure. The pandemic has intensified these trends by disrupting markets and trafficking routes, which has, in turned, fueled clashes over the control of territory. Similar trends can be seen in Honduras, where both gang violence and the associated death toll have spiked due to intergang fighting between the larger mara groups like MS-13 and Barrio 18 and smaller local gangs.

Local security providers have long protected their communities wherever the state is not trusted to guarantee security. These groups can be formally organized, as is the case with local communal militias, or can come together spontaneously, as in the case of vigilante mobs taking justice into their own hands. Local security providers have reacted to perceived threats to their communities during previous health crises, such as in response to cholera in Brazilian favelas, to HIV/AIDS in Haiti, or to SARS in New Yorks Chinatown neighborhood.

Mob violence targeting those thought to be spreading the virus increased throughout the COVID-19 pandemic (as can be seen in the map below). In China, in the early days of the pandemic, there were reports of vigilantes acting as epidemic prevention personnel, assaulting those not wearing masks. In India, mobs targeted Muslims, whom they blamed for the spread of the coronavirusa rumor stoked by a leader of the ruling Bharatiya Janata Party, who called for a boycott of Muslim vendors. In Central America, including in Costa Rica and Panama, residents blocked roads or entries to their communities to keep the virus out. Around the world, and in India especially, health care workers have been targeted due to the fear that they spread the virus given their work in close proximity to those infected. Across the United Kingdom and the Netherlands, attacks on 5G telecommunications towers have taken place following disinformation campaigns that the towers are linked to the spread of the virus. Unrest in prisons, too, has risen around the world alongside fears of close quarters and poor detention conditions fueling the spread of COVID-19.

Global Mob Violence Since WHO Pandemic Announcement

As infection rates begin to decline in many parts of the world and restrictions are lifted, violence involving nonstate actors will likely continue. Mob violence, too, will remain possible, targeting those who are marginalized or blamed for the crisis.

State leaders, especially those facing upcoming reelection, will be assessed based on their response to the pandemic. Those perceived to be tackling the crisis effectively, such as New Zealand Prime Minister Jacinda Ardern, are likely to see a surge in public support. Those perceived to have been ineffectivesuch as U.S. President Donald Trumpmay suffer the consequences. In countries where leaders expanded and entrenched their powers, state repression is likely to continue, with the opposition increasingly stifled. And in other nations, particularly where the health of the current regime was impacted, there may be instability among the senior ranks, such as in Iran, where a number of senior leaders were infected, or in Burundi, where President Pierre Nkurunziza, who died in June just weeks after elections that were marred by violence, is thought to be the first head of state to die from COVID-19 complications.

A rise in demonstrations around the world has already begun, and a resurgence in pre-pandemic social movements is expected, especially as the health crisis has only served to further exacerbate many of the original grievances that spurred these movements. Extreme events like the coronavirus pandemic have significant and direct impacts on disorder. Governments can adopt immediate legislation to limit the activity of citizens, and state and nonstate actors alike can exploit the unrest surrounding a pandemic, natural disaster, or the like to advance their political priorities. To address the impact of these shocks on foreign policy, access to data during such contentious periods is paramount. Policymakers and other stakeholders not only need real-time data on the rate and spread of medical cases during a pandemic in order to craft an appropriate public health response, but they also need real-time data collection infrastructure to track how a pandemic affects political violence and protest trends in parallel. Only then can they develop appropriate security policies that complement their public health policies by anticipating how the latter may disrupt the security environmentensuring that security and public health responses work in tandem, rather than in opposition.

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Protests, Violence, and MafiasHow the Coronavirus Has Impacted Conflicts Across the Globe - Foreign Policy

50 Movies that address the history of racism in America – WRCB-TV

40 Acres and a Mule Productions

50 movies that address the history of racism in America

Movies give us perspective and allow us to watch certain events play out in front of our eyes. They can be educational and entertaining, making proper representation a significant factor in filmmaking. Black representation in Hollywood was almost nonexistent in the early 20th century, and when images of African Americans were shown, they were given negative stereotypes and criticized with racist imagery and oppression.

Years of systematic racism riddle the Black community today, but it was even more blatant back then. Young Black children around the country would turn on the television to a lack of positive images outside of racial stereotypes. As the years went on, Black representation slowly but surely began to make its way through the airwaves, and it started to educate people on the realities of Black lives as many Black filmmakers, actors, and writers created a new cycle of Black cinema with a variety of genres.

Black films have become a staple in the Black community, leaving long-lasting impacts on the culture for years to come. Black artistry continues to rise in theaters and on television as the industry learns to cater to different skin types, film angles, genre diversities, and plot lines within Black culture.

Stackerextensively researched the history of Black filmmaking and Black lives captured on screen in both fiction features and documentaries, and compiled a list of 50 diverse films that address the history of racism in America in one way or the other using IMDbdata as of June 3, 2020. To amplify Black voices and firsthand experience, the overwhelming majority of the films on this list are made by Black filmmakers.The films are organized chronologically.

Check out these stories that shine a light on Black voices throughout cinema.

Micheaux Book & Film Company

- Director: Oscar Micheaux- IMDb user rating: 6.3- Metascore: data not available- Runtime: 79 min

"Within Our Gates" follows a mixed-race woman who ventures North during the Jim Crow era in hopes of raising money for a Black school in the South. Oscar Micheaux, the first major African American feature-filmmaker, portrays racial violence and strict contrasts between the Black people who lived in rural areas to those who migrated to urban cities. The silent film is highly critiqued to be a response to D.W. Griffith's "Birth of a Nation," and a turning point for African American cinema.

- Director: John Cassavetes- IMDb user rating: 7.3- Metascore: 86- Runtime: 87 min

Leila, a white-passing, Black woman in New York City, falls in love with a white man, but the relationship ends when he meets her dark-skinned brother and realizes she is Black. Leila and her two brothers navigate their racial identity with their skin complexion at the forefront of their narratives. This movie brings awareness to the multifaceted issues that surround Black livelihood.

A Raisin in the Sun (1961)

- Director: Daniel Petrie- IMDb user rating: 8.0- Metascore: 87- Runtime: 128 min

Attempting to fulfill the American dream in a racially segregated Chicago, a Black family looking to buy a home in a white neighborhood becomes a victim of housing discrimination and racial threats. The film addresses the racial injustices Black people face when attempting to follow their dreams, bearing the question, "what happens to a dream deferred?"

Guess Who's Coming to Dinner (1967)

- Director: Stanley Kramer- IMDb user rating: 7.8- Metascore: 63- Runtime: 108 min

This classic film depicts a couple's interracial love as they confront each other's family members' initial disapproval. Katharine Houghton and Sidney Poitier's characters dive deep into the anti-miscegenation laws of the time and explore certain hypocrisies that potentially stem from white-liberalism.

In the Heat of the Night (1967)

- Director: Norman Jewison- IMDb user rating: 7.9- Metascore: 75- Runtime: 110 min

In this five-time Academy Award-winning movie, a Black detective (Sidney Poitier) gets caught in the middle of a murder investigation and eventually proves his innocence. After his release, he's now in charge of the case but faces difficulties when he's partnered with the racist sheriff (Rod Steiger), who accused him of murder. The film was shot during the civil rights movement and examined racial policing and bigotry.

Symbiopsychotaxiplasm: Take One (1968)

- Director: William Greaves- IMDb user rating: 7.3- Metascore: 71- Runtime: 75 min

William Greaves experiments "a film within a film within a film." While at times baiting his predominantly white crew over political topics, Greaves allows the actors to follow their narratives on issues of race and sexuality. In fact, the lack of direction is how he wanted to bring out the reality of his crew's thoughts on screen.

The Story of a Three-Day Pass (1968)

- Director: Melvin Van Peebles- IMDb user rating: 7.0- Metascore: data not available- Runtime: 87 min

An African American soldier named Turner is stationed in France and struggles with his own identity as a Black man in the army. After meeting and spending the weekend with a French woman, Turner finds that he is not exempt from racial prejudices, and he's forced to face his lack of freedom and discrimination within the military.

Warner Bros. - Seven Arts.

- Director: Gordon Parks- IMDb user rating: 7.1- Metascore: data not available- Runtime: 107 min

Gordon Parks tackles adolescent sexuality, morality, and racism, centering a young Black teenager in 1920s rural Kansas. The tragic trial of events portrayed in the film speaks volumes to the harsh realities Black Americans face beginning at a young age.

Cotton Comes to Harlem (1970)

- Director: Ossie Davis- IMDb user rating: 6.5- Metascore: data not available- Runtime: 97 min

This slapstick comedy is widely known as one of the earliest examples of blaxploitation. Popular throughout the 1970s, the genre has been criticized but also praised by the Black community for characters who, at their core, promote messages of Black empowerment. The story follows a man attempting to raise money to return to Africa (mirroring the teachings of Marcus Garvey), all of which was actually an elaborate scam.

- Director: Martin Ritt- IMDb user rating: 7.5- Metascore: 80- Runtime: 105 min

A Black sharecropping family and their dog experience extreme poverty during the Great Depression. They fight to survive after the father is jailed for stealing food. Starring Cicely Tyson, the story themes prison labor, Black poverty, and access to education within the Black community.

The Spook Who Sat by the Door (1973)

- Director: Ivan Dixon- IMDb user rating: 7.1- Metascore: data not available- Runtime: 102 min

"The Spook Who Sat by the Door" follows the first Black man in a fictional CIA, who is aware of his token status in the agency. After learning a few techniques from the agency, he organizes the "Freedom Fighters" to help protect Black Americans and ensure their freedom. The film addresses the need for Black people's self-defense, a notion practiced during the civil rights movement.

- Director: Bill Gunn- IMDb user rating: 6.3- Metascore: data not available- Runtime: 110 min

One of the first few horror films to have Black representation, Bill Gunn plays his own lead in "Ganja & Hess" and portrays diversity and range for Black actors in cinema. The film presents two Black lovers who've been killed and have emerged as immortal vampires. Initially pitched as a blaxploitation film, the movie is more experimental and artistic.

- Director: Charles Burnett- IMDb user rating: 7.3- Metascore: 96- Runtime: 80 min

This black-and-white film follows a Black man who works in a slaughterhouse to feed his family. While the adults face challenges of their own, the children are almost accustomed to their dangerous surroundings. The film mirrors the harsh realities of the ghetto, trauma, and financial struggle due to racial inequity from childhood to adulthood.

- Director: Kathleen Collins- IMDb user rating: 6.4- Metascore: data not available- Runtime: 86 min

Sara, a young Black woman, is having trouble with her marriage after her husband sparks interest in a Puerto Rican woman, causing Sara to question her own identity and self-worth being both Black and a woman. "Losing Ground" was one of the first feature-length films created by a Black woman.

40 Acres and a Mule Productions

She's Gotta Have It (1986)

- Director: Spike Lee- IMDb user rating: 6.7- Metascore: 79- Runtime: 84 min

The themes of "She's Gotta Have It" include gender, Black feminism, and sexual liberation. Nola Darling lives a sexually liberated lifestyle with three men before she is forced to choose one lover. Spike Lee examines the representation of Black women's wellness and freedom of stereotypes.

- Director: Marlon Riggs- IMDb user rating: 6.7- Metascore: data not available- Runtime: 55 min

This documentary focuses on the expression of gay Black men and their culture. Marlon Riggs explores the intersectionality of being both Black and gay in a racist and homophobic society. Riggs shines a light on many issues the community faces, including examples of hypersexualized Black men in relation to their white counterparts.

40 Acres and a Mule Productions

Do the Right Thing (1989)

- Director: Spike Lee- IMDb user rating: 7.9- Metascore: 92- Runtime: 120 min

A series of racially motivated events is outlined after an Italian-owned restaurant has a wall-of-fame with only Italian actors in a predominantly Black neighborhood. Believing there should be Black actors on the wall, heightened emotions on race relations lead to a race riot. This staple in the Black community is a representation of racial inequity and injustices themed across the country today.

Daughters of the Dust (1991)

- Director: Julie Dash- IMDb user rating: 6.5- Metascore: 81- Runtime: 112 min

This film portrays the effects of Black enslavement past the borders of America and into West Africa and creolized cultures. A family of women in the Gullah community struggles to carry on their vibrant Yoruba culture away from their homeland. Julie Dash's film heavily inspired Beyonce's "Lemonade" video as it explores Black womanhood and the search for freedom after slavery.

- Director: John Singleton- IMDb user rating: 7.7- Metascore: 76- Runtime: 112 min

Based on his own life, John Singleton portrays three young Black men in a neighborhood riddled with poverty, gang violence, and other harsh issues that hit the community. Each man navigates their path through Central Los Angeles when tragedy strikes, symbolizing a trauma cycle of "what's going on in the hood."

Just Another Girl on the I.R.T. (1992)

- Director: Leslie Harris- IMDb user rating: 6.4- Metascore: data not available- Runtime: 92 min

Chantel Mitchell is a Black, 17-year-old high schooler from Brooklyn, New York, who dreams of going to college and hopes to become a doctor. Her plans fall short when she becomes pregnant. Mitchell copes with her fears of becoming a statistic, riddled with stereotypes that follow young Black girls.

40 Acres and a Mule Productions

- Director: Spike Lee- IMDb user rating: 7.7- Metascore: 72- Runtime: 202 min

Malcolm X was a Black activist who taught against racism and white violence while promoting Black empowerment and separation. Denzel Washington gives a powerful performance of the real-life events in the activist's life and his impact on the Black community; many sentiments still followed and repeated to this day.

- Director: Steve James- IMDb user rating: 8.3- Metascore: 98- Runtime: 170 min

This documentary follows two Black teenage boys from a predominantly Black neighborhood in Chicago. They attend a predominately white school in hopes of pursuing their dreams of becoming professional basketball players. The film constantly touches on race, social class, and the education system with topics in code-switching, economic hardships, and racism.

Devil in a Blue Dress (1995)

- Director: Carl Franklin- IMDb user rating: 6.7- Metascore: 78- Runtime: 102 min

Denzel Washington makes another appearance on the list as a World War II veteran. He finds himself entangled in a case involving a missing white woman. Racism is at the center of the story's plot as Washington's character is consistently demeaned and belittled, and the film portrays an overall lack of care for Black lives by society.

The Watermelon Woman (1996)

- Director: Cheryl Dunye- IMDb user rating: 6.7- Metascore: 74- Runtime: 90 min

In the first feature film directed by a Black lesbian woman, Cheryl, who plays herself in the film, is a struggling filmmaker who hopes to make a film about a Black lesbian character who is often belittled to "mammy" roles in early 20th century movies. The movie explores lesbianism, Blackness, and womanhood as each can intersect and coexist to their fullest identity.

- Director: Maya Angelou- IMDb user rating: 6.7- Metascore: 73- Runtime: 112 min

Alfre Woodard stars in "Down in the Delta" as a character named Loretta, who is sent to Mississippi from Chicago to get clean from drugs and reconnect with her family's traditions. As a result of slavery, Black Americans have difficulties following family trees and often hit dead ends. Maya Angelou gives us a story of family, heritage, and traditions reborn.

- Director: Spike Lee- IMDb user rating: 6.5- Metascore: 50- Runtime: 135 min

This satirical piece mirrors early 20th-century film as a television executive (Damon Wayans) decides to bring minstrel shows back to television. The film hits many racist stereotypes throughout including blackface, "jive" dances, and other racist tropes. The abstract film leans into old portrayals of Black characters as an examination of the past, present, and future of Black film.

How to Eat Your Watermelon in White Company (and Enjoy It) (2005)

- Director: Joe Angio- IMDb user rating: 7.2- Metascore: 70- Runtime: 85 min

This documentary discusses Melvin Van Peebles' story and his breakthrough into Hollywood. Peebles' filmmaking style of the 1970s is highlighted throughout the film as a call for revolution within the Black community and more Black representation in film.

The Untold Story of Emmett Louis Till (2005)

- Director: Keith Beauchamp- IMDb user rating: 7.6- Metascore: 80- Runtime: 70 min

Emmett Till was a Black, 14-year-old child from Chicago who, on a visit to his great-uncle's home in Mississippi, was brutally murdered by two white men. This documentary tells the story of Till, his murderer's acquittal in court by an all-white, all-male jury, and the racial uprising that followed in the 1950s. The film emphasizes the injustices of the racist South and white violence against the Black community.

The Great Debaters (2007)

- Director: Denzel Washington- IMDb user rating: 7.5- Metascore: 65- Runtime: 126 min

Denzel Washington directs and stars in this true story of a Black professor's quest to begin a debate team at Wiley College, during the Great Depression. The now-legacy was unheard of at the time as Jim Crow laws were as prominent as ever, and the fear of violence against the Black community rang high. The film is a testament to the team and its coach for overcoming a racially unjust society.

- Directors: Carl Deal, Tia Lessin- IMDb user rating: 7.3- Metascore: 83- Runtime: 93 min

"Trouble the Water" journeys a young Black couples' tragedy during Hurricane Katrina. The film shows predominantly Black neighborhoods flooded, families destroyed, and people killed during the natural disaster. The film is a visual displaying the lack of government support due to racism and classism during the historical event.

The Black Power Mixtape 1967-1975 (2011)

- Director: Gran Olsson- IMDb user rating: 7.5- Metascore: 73- Runtime: 100 min

"The Black Power Mixtape" documents the Black Power movement and its turning points within Black history. The found footage touches on many topics presented during the movement, including Dr. King's assassination, the War on Drugs, Black nationalism, and more.

- Director: Steve McQueen- IMDb user rating: 8.1- Metascore: 96- Runtime: 134 min

This slave memoir adaptation tells the story of a free Black man named Soloman, who was kidnapped and sold into slavery. For 12 years, Solomon faced the brutalities of slavery, as he jumps from one plantation to the next in hopes to find his way back home. The film, which can be hard to watch, portrays some harsh realities Black people faced during centuries of enslavement.

- Director: Ryan Coogler- IMDb user rating: 7.5- Metascore: 85- Runtime: 85 min

Oscar Grant was a Black, 22-year-old man who was shot and killed by a white police officer in Oakland's Fruitvale district station. Michael B. Jordan portrays the young man, who faced with deprivations as a Black man in America, journeyed through life as a Bay Area resident before his tragic murder. With footage caught on film, Grant's story brought a call for change towards police brutality and racial profiling that happens every day towards Black people.

- Director: Justin Simien- IMDb user rating: 6.1- Metascore: 79- Runtime: 108 min

This Netflix special follows a group of Black students at a predominantly white university. The students navigate cultural biases at the Ivy League college, and the story mirrors real-life social injustices that mark Black students in similar positions.

- Director: Ava DuVernay- IMDb user rating: 7.5- Metascore: 81- Runtime: 128 min

Ava DuVernay takes us into the story of Dr. Martin Luther King Jr.'s march on Selma in the fight for Black suffrage. The historical context speaks to Black people's relationship with the government as they are forced to navigate the judicial system as second-class citizens. The film follows the events of Dr. King's eventual push towards the Voting Rights Act of 1965.

- Director: Theo Anthony- IMDb user rating: 6.6- Metascore: 83- Runtime: 82 min

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50 Movies that address the history of racism in America - WRCB-TV

How research groups are tackling the problem of biologic drug delivery – Pharmaceutical Technology

]]> What are the challenges to developing more convenient, oral-based biologics? Credit: Shutterstock.

Sign up here for GlobalData's free bi-weekly Covid-19 report on the latest information your industry needs to know.

Over the past few decades, the rise of biologics has been nothing short of meteoric. Between 2010 and 2017, around a quarter of the new molecular entities approved by the US Food and Drug Administration (FDA) fell into this bracket (63 out of a total of 262). That may not sound like a lot, but since biologics are much more expensive than small molecule drugs, they account for most of the worlds top-selling drugs by revenues. They also represent one of the fastest growing categories in pharma.

Unfortunately, biologics have a major downside when it comes to delivery. Unlike small molecule drugs, which can generally be taken orally, biologics are large, complex entities that degrade rapidly in the gastrointestinal tract. Weighing between 200 and 1,000 times the size of a small molecule drug, they almost always need to be delivered via injection or infusion. This is far less convenient than swallowing a pill, not to mention far more costly.

To take diabetes management as an example, most people with diabetes still rely on multiple daily injections. Inhalable insulin has been tried out (as per Exubera in 2006 and Afrezza in 2014) but both suffered with safety concerns and poor sales volume. Oral insulin the holy grail of diabetes treatment has yet to hit the market.

There are dozens of groups around the world intent on creating oral delivery methods. Some focus on modifying the drugs chemical structure to improve their stability in the body. Others focus on the epithelial barrier in the gut if you can make that more permeable, large molecules will be able to pass through more easily.

To give an example of the first approach, researchers at EFPL in Switzerland are working on a method to deliver peptides orally. In 2018, the team developed double bridged peptides a structure with much more stability than a typical amino acid chain. Unfortunately, despite this added stability, most of them still disintegrated in the digestive tract.

Since then, the researchers have found a way to trawl through a peptide library (billions of random peptide sequences, twisted into the double bridged format) to identify the ones that actually are stable. After they have isolated the surviving candidates, they do further tests to find the ones that bind to the disease target.

Its a bit like searching for a needle in a haystack, and this method makes this easy, said Professor Christian Heinis, the lead researcher.

An example of the latter approach comes from Israeli biotech Chiasma. Its Transient Permeability Enhancer (TPE) aims to protect drug molecules from digestive enzymes, as well as triggering the temporary expansion of tight spaces in that gut barrier.

This gives just enough space for the drug molecule to pass into the bloodstream, but not enough space for viruses and bacteria. Last year, the company completed a phase III trial on oral capsules called Mycapssa, which could be used as a maintenance treatment for acromegaly.

There are also a number of oral delivery approaches involving nanoparticles. As the thinking goes: if you incorporate the drug into tiny transporting particles, those particles will be able to protect it from stomach acid, as well as accurately targeting its delivery.

Researchers at Houston Methodist Research Institute in Texas are trialling one such approach, in which a peptide-based drug is chemically linked to fatty acids, and packaged in a nanoparticle. In mouse studies, the animals absorbed almost a quarter of the drug dosage (a lot, considering the typical oral bioavailability for a biologic stands at around 1%).

We know the human body can absorb fatty acids, so we decided to chemically link biological drug molecules to fatty acids to see how well these drugs are absorbed into the gastrointestinal system. It turns out that our transporter approach was effective, saidDr Haifa Shen, Professor of Nanomedicine at Houston Methodist.

Nanotechnology could have many further applications within drug delivery. In particular, it could be used for delivering drugs across the blood-brain barrier, a network of blood vessels that functions a bit like neurological armour. While this barrier protects the brain from harmful chemicals, it also prevents therapeutic agents from getting through.

Researchers at Cedars-Sinai Medical Center in California are working on a new type of nano-immunotherapy, which could deliver cancer drugs directly into brain tumours. Again, they are at an early stage of research, but mouse studies have shown promising results.

Current clinically proven methods of brain cancer immunotherapy do not ensure that therapeutic drugs cross the blood-brain barrier, said Dr Julia Ljubimova, Professor of Neurosurgery and Biomedical Sciences at Cedars-Sinai. Although our findings were not made in humans, they bring us closer to developing a treatment that might effectively attack brain tumours with systematic drug administration.

Another exciting research avenue is microneedles. The promise is clear a minimally invasive, painless technique that could deliver the drug through the skin.

One example is a smart, adhesive insulin-delivery patch, being developed by bioengineers at UCLA. The patch, which is adhesive and resembles a sticking plaster, is pre-loaded with insulin and releases the medicine once blood sugar levels exceed a certain threshold. The technology has been accepted into the FDAs Emerging Technology Program, and human trials could start within the next few years.

US biotech Rani Therapeutics is combining both approaches microneedles and oral biologics delivery with its so-called robotic pill. This capsule, which could be used to deliver a number of biologics, moves through the stomach intact, before reaching the desired location in the gut. Here, it releases biodegradable microneedles, which inject the biologic.

This delivery system is still at an early stage of development, but in preclinical tests it performed as well as a subcutaneous injection. The company also has one human trial to its name a phase I trial for a drug called octreotide, which is normally injected intravenously.

While these research groups, and many others, are seeing promising results in the lab and early trials, it remains to be seen which new delivery methods will become a clinical reality. Given the challenges associated with existing delivery methods, and the seemingly unstoppable rise of biologics, there is everything to play for.

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How research groups are tackling the problem of biologic drug delivery - Pharmaceutical Technology

NanoViricides to Participate in Panel Discussion at the B. Riley FBR Virtual Infectious Disease Summit Today, July 21, 2020 – BioSpace

SHELTON, CT / ACCESSWIRE / July 21, 2020 / NanoViricides, Inc. (NYSE American:NNVC) (the "Company") a global leader in the development of highly effective antiviral therapies based on a novel nanomedicines platform, today announced that Anil R. Diwan, PhD, President and Executive Chairman of the Company, will participate in the "B. Riley FBR Virtual Infectious Disease Summit - Therapeutics Day" on Tuesday, July 21, 2020. The Conference is organized by B. Riley FBR, Inc. (https://brileyfbr.com/).

Dr. Diwan is invited to participate in Panel #3 at 2020 at 2:10 p.m. ET, entitled "Taming the Severe Disease Presentations". He will briefly discuss the Company's novel nanomedicines platform and the Company's progress in the lead IND-ready candidate for the treatment of shingles rash, NV-HHV-101, as well as in developing a drug candidate against SARS-CoV-2, the cause of COVID-19 global pandemic.

The Company believes that it is close to selecting a clinical candidate worthy of advancing into human clinical trials for the treatment of SARS-CoV-2 infection, based on (i) cell culture effectiveness studies against multiple circulating coronaviruses that employ different cell surface receptors, (ii) a lethal lung infection animal model effectiveness study using hCoV-NL63 infection (a coronavirus that uses the same receptor, ACE2, as SARS-CoV-2, and produced similar disease in the animal model), and (iii) preliminary safety studies in animal model at maximum feasible dosage levels. The Company has disclosed its findings from these studies in previous press releases.

Prior to filing for human clinical trials, NanoViricides plans on conducting studies, towards clinical candidate selection, to further determine the effectiveness against SARS-CoV-2, perform additional drug development studies as may be necessary, and request a pre-IND Meeting with the US FDA for regulatory guidance.

The Company is also working with its regulatory consultants on completing an IND with the US FDA to advance its lead drug candidate NV-HHV-101 into human clinical trials for topical dermal treatment of Shingles rash as the initial indication. In particular, the Company is working on finalizing the clinical trials plan for the anticipated human clinical trials for shingles rash treatment. The Company is also in the process of finalizing clinical trial sites. This process has been adversely affected by the current global COVID-19 pandemic, and in particular, its effects across the USA.

Importantly, nanoviricides are designed to act by a novel mechanism of action, trapping the virus particle like the "Venus-fly-trap" flower does for insects. Antibodies, in contrast, only label the virus for other components of the immune system to take care of. It is well known that the immune system is not functioning properly at least in severe COVID-19 patients.

Additionally, it is well known that viruses escape antibody-drugs via mutations. The Company's "nanoviricide" drug candidates, in contrast, are designed to be broad-spectrum, and therefore virus escape by mutations is expected to be unlikely.

The market size for the treatment of shingles is estimated at approximately one billion dollars by various estimates. These estimates take into account the Shingrix vaccine as well as existing vaccines. About 500,000 to 1 million cases of shingles occur in the USA alone every year.

The market size for our immediate target drugs in the HerpeCide program is variously estimated at billions to tens of billions of dollars. The Company believes that its dermal topical cream for the treatment of shingles rash will be its first drug heading into clinical trials. The Company believes that additional topical treatment candidates in the HerpeCide program, namely, HSV-1 "cold sores" treatment, and HSV-2 "genital ulcers" treatment are expected to follow the shingles candidate into IND-enabling development and then into human clinical trials. These additional candidates are based on NV-HHV-101, thereby maximizing return on investments and shareholder value.

The Company develops its class of drugs, that we call nanoviricides, using a platform technology. This approach enables rapid development of new drugs against a number of different viruses. A nanoviricide is a "biomimetic" - it is designed to "look like" the cell surface to the virus. The nanoviricide technology enables direct attacks at multiple points on a virus particle. It is believed that such attacks would lead to the virus particle becoming ineffective at infecting cells. Antibodies in contrast attack a virus particle at only a maximum of two attachment points per antibody.

In addition, the nanoviricide technology also simultaneously enables attacking the rapid intracellular reproduction of the virus by incorporating one or more active pharmaceutical ingredients (APIs) within the core of the nanoviricide. The nanoviricide technology is the only technology in the world, to the best of our knowledge, that is capable of simultaneously (a) attacking extracellular virus to break the reinfection cycle, and (b) disrupting intracellular production of the virus, thus enabling complete control of a virus infection.

About NanoViricidesNanoViricides, Inc. (www.nanoviricides.com) is a development stage company that is creating special purpose nanomaterials for antiviral therapy. The Company's novel nanoviricide class of drug candidates are designed to specifically attack enveloped virus particles and to dismantle them. Our lead drug candidate is NV-HHV-101 with its first indication as dermal topical cream for the treatment of shingles rash. The Company is in the process of completing an IND application to the US FDA for this drug candidate. The Company cannot project an exact date for filing an IND because of its dependence on a number of external collaborators and consultants, and the effects of recent COVID-19 restrictions.

The Company is also developing drugs against a number of viral diseases including oral and genital Herpes, viral diseases of the eye including EKC and herpes keratitis, H1N1 swine flu, H5N1 bird flu, seasonal Influenza, HIV, Hepatitis C, Rabies, Dengue fever, and Ebola virus, among others. NanoViricides' platform technology and programs are based on the TheraCour nanomedicine technology of TheraCour, which TheraCour licenses from AllExcel. NanoViricides holds a worldwide exclusive perpetual license to this technology for several drugs with specific targeting mechanisms in perpetuity for the treatment of the following human viral diseases: Human Immunodeficiency Virus (HIV/AIDS), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Rabies, Herpes Simplex Virus (HSV-1 and HSV-2), Varicella-Zoster Virus (VZV), Influenza and Asian Bird Flu Virus, Dengue viruses, Japanese Encephalitis virus, West Nile Virus and Ebola/Marburg viruses. The Company has executed a Memorandum of Understanding with TheraCour that provides a limited license for research and development for drugs against human coronaviruses. The Company intends to obtain a full license and has begun the process for the same. The Company's technology is based on broad, exclusive, sub-licensable, field licenses to drugs developed in these areas from TheraCour Pharma, Inc. The Company's business model is based on licensing technology from TheraCour Pharma Inc. for specific application verticals of specific viruses, as established at its foundation in 2005.

This press release contains forward-looking statements that reflect the Company's current expectation regarding future events. Actual events could differ materially and substantially from those projected herein and depend on a number of factors. Certain statements in this release, and other written or oral statements made by NanoViricides, Inc. are "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. You should not place undue reliance on forward-looking statements since they involve known and unknown risks, uncertainties and other factors which are, in some cases, beyond the Company's control and which could, and likely will, materially affect actual results, levels of activity, performance or achievements. The Company assumes no obligation to publicly update or revise these forward-looking statements for any reason, or to update the reasons actual results could differ materially from those anticipated in these forward-looking statements, even if new information becomes available in the future. Important factors that could cause actual results to differ materially from the company's expectations include, but are not limited to, those factors that are disclosed under the heading "Risk Factors" and elsewhere in documents filed by the company from time to time with the United States Securities and Exchange Commission and other regulatory authorities. Although it is not possible to predict or identify all such factors, they may include the following: demonstration and proof of principle in preclinical trials that a nanoviricide is safe and effective; successful development of our product candidates; our ability to seek and obtain regulatory approvals, including with respect to the indications we are seeking; the successful commercialization of our product candidates; and market acceptance of our products. FDA refers to US Food and Drug Administration. IND application refers to "Investigational New Drug" application. CMC refers to "Chemistry, Manufacture, and Controls". ]

Contact:NanoViricides, Inc.info@nanoviricides.com

Public Relations Contact:MJ ClyburnTraDigital IRclyburn@tradigitalir.com

SOURCE: NanoViricides, Inc.

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NanoViricides to Participate in Panel Discussion at the B. Riley FBR Virtual Infectious Disease Summit Today, July 21, 2020 - BioSpace

Cardiac Rehabilitation Market Projected to Grow at a CAGR of 6.4% During the Forecast Period 2020-2025 – MENAFN.COM

(MENAFN - iCrowdNewsWire) Jul 21, 2020

Cardiac Rehabilitation Market size was valued at $1.31 Billion in 2019, and is projected to grow at a CAGR of 6.4% during the forecast period 2020-2025. The growth rate can be attributed to the inclination of the mass towards a lifestyle that helps curb various cardiovascular diseases. Technological advancements such as tele-cardiac rehabilitation can also be considered to contribute to the growth of the market. Apart from this, there has also been an increase in number of health-conscious people which is said to further add to the growth of the Cardiac Rehabilitation market.

By Device Type - Segment Analysis On the classification made on device type, Treadmills dominated the cardiac rehabilitation market in the year 2019. The reason behind its dominance is the percentage of sales held by treadmills at various cardiac rehabilitation centers globally. This is owing to a large share of population are adopting better lifestyle, with an intention of getting rid of various cardiovascular diseases and obesity and are increasingly fitness conscious. Apart from this, the blood pressure and the heart rate monitor devices are also to witness growth in the segmental share during the forecast period 2020- 2025 owing to the digitalization of the devices along with the changes done in the infrastructure of the healthcare centers for installation of these devices.

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By Disease Type Segmental Analysis Coronary Artery Bypass Grafting dominated the market and is projected to grow with a CAGR of 6.3% during the forecast period. The reason behind the fast growth of this segment is because of the increase in the geriatric population with unhealthy dietary habits, irregularity in exercising and smoking habits. This leads to various coronary artery diseases and after treatment followed by cardiac rehabilitation. Cardiac rehabilitation is a medical program designed especially for people who have had a heart attacks, heart failures, heart valve surgeries, etc., which involves adoption of heart healthy lifestyle. All these above-mentioned factors are anticipated to contribute to the market growth during the forecast period.

By Geography - Segment Analysis North America dominated the Cardiac Rehabilitation Market with a regional share of 42% in 2019. The sector for Cardiac Rehabilitation has grown rapidly over the last few years. The U.S. remains the largest market contributor of Cardiac Rehabilitation in the region of North America, because of the high ratio of cardiovascular patients owing to their lifestyle and significant population. Thus, North America is said to be the dominant market of Cardiac Rehabilitation in the prediction period.

However, APAC region is estimated to witness the fastest CAGR during the forecast period 2020-2025 owing to rise in geriatric population, improvement in health care infrastructure. There has also been increase in the number of health and fitness conscious people. Along with this, country-level initiatives are taken by respective governing bodies which is also likely to propel the Cardiac Rehabilitation Market in these countries.

Drivers Cardiac Rehabilitation Market

Rise in Geriatric population and increase prevalence of various cardiovascular diseasesRise in the geriatric population and associated rise in cardiovascular diseases are said to be driving the cardiac rehabilitation market. Also, in various countries, owing to the advancements made in infrastructure across various healthcare sectors Cardiac Rehabilitation Market growth is further driven. Along with this, there is a rising prevalence of various cardiovascular diseases has led to increase in initiatives by various government bodies that are aimed to curb the problems like unavailability of equipment's and devices at affordable prices.

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Challenges Cardiac Rehabilitation Market

Increase in the cost of purchasing of Cardiac Rehabilitation Devices The major challenge for the market is the inconvenience in the compliance of Cardiac Rehabilitation devices and equipment's to the various hospitals and clinics. Though there has been a significant growth in the market of Cardiac Rehabilitation, but the market is expected to be challenged by these factors as well as high cost of installation of the equipment's and devices in cardiac rehabilitation.

Cardiac Rehabilitation Industry Outlook Product launches, mergers and acquisitions, joint ventures and geographical expansions are key strategies adopted by players in the Cardiac Rehabilitation Market. In 2019, Cardiac Rehabilitation Market share is fragmented by the top ten players present in the market. Cardiac Rehabilitation Market top 10 companies are Brunswick Corporation, Honeywell International. Inc., Smiths Group, OMRON Corporation, Halma plc, Core Health & Fitness, Life Watch, Philips, Amer Sports and Patterson Companies.

Acquisitions/Product Launches In September 27, 2019 Royal Philips announced the shipment of its two-million AED (Automated External Defibrillator) which marks as a milestone for the efforts to meet the demands to combat SCA(Sudden Cardiac Arrest).

In April 08, 2019, Royal Philips debuted an ultrasonic system, to provide exceptional image clarity and sharpness, improved exam efficiencies, more robust and reproducible quantification, enabled by anatomical intelligence along with extraordinary processing power.

Key Takeaways North America dominated the Cardiac Rehabilitation Market with a share of 42% in 2019.

With the rise in the geriatric population and rise in prevalence of cardiovascular diseases in various countries along with the advancements made in infrastructure in various healthcare sectors are among the key drivers of the Cardiac Rehabilitation Market.

Cardiac rehabilitation is a medical program designed especially for people who have had a heart attacks, heart failures, heart valve surgeries, etc., which involves adoption of heart healthy lifestyle.

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A. Rehabilitation Products Market

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B. Specialty Medical Chairs Market

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Cardiac Rehabilitation Market Projected to Grow at a CAGR of 6.4% During the Forecast Period 2020-2025 - MENAFN.COM

Global Sweet and Savory Snacks Market to 2026 – Key Drivers, Restraints and Opportunities – ResearchAndMarkets.com – Business Wire

DUBLIN--(BUSINESS WIRE)--The "Global Sweet and Savory Snacks Market: Consumer Behavior Analysis by Countries, Buying Pattern Analysis, Demographics, Trends Analysis, Survey Findings and Results, Leading Companies and their Market Strategies" report has been added to ResearchAndMarkets.com's offering.

The global sweet and savory snacks market size was valued at USD 155 billion in 2019 and is anticipated to expand at a CAGR of 6.17% in terms of value during the forecast period.

Sweet and savory snacks are a solution to the various needs of modern consumers, and they use it between meals or as their replacement. The major players in the market are branching out from original recipes and introducing line extensions that deliver attractive ingredients, flavors, and textures to consumers looking for new experiences or alternative ingredients for health reasons. The products such as popcorn chips, nut flour crackers, and jerky prepared from non-meat resources on store shelves. A number of the retail outlet's grocery stores, convenience stores, warehouse club stores, and roadside vendors are tantalizing consumer's taste buds. It makes good business sense to have snacks always at the ready and within arm's reach as many snack purchases are unplanned.

Nutrition really is the key to a healthy lifestyle and a healthy life. Rising demand for nutritious snacks is driving the demand for sweet and savory snacks as it is lowering the risk for heart disease and improving overall health. Other benefits of choosing nutritious snacks are they packed with nutrients, vitamins, and minerals that will fuel the body and keep blood sugar levels steady. It plays a vital role in maintaining a healthy diet and helps to manage hunger in between meals and keep blood sugar at proper levels. Nutritious sweet and savory snacks improve overall health, curb cravings, fights weight gain, regulates mood, enhances brainpower, and gives the energy required to keep going all day.

The U.S. is the largest sweet and savory snacks consuming nation as it holds more than 60% market share of North America sweet and savory snacks market and approximately 20% market share of global sweet and savory snacks market. The consumers increasingly prefer snacks with high-protein content and low-calorie count that are driving the demand for sweet and savory snacks in the United States. China represents the market of growth for product developers with the nations' booming populations, rising disposable incomes, convenience-demanding lifestyles, and the increase of western influences in their daily lives. Germany also holds a significant market share in the global sweet and savory snacks market by country. The long-term rise in snacking on-the-go and rise in snacking between meals is increasing demand in Germany.

The author has published a comprehensive research study based on a survey conducted to analyze the buying patterns, consumer behavior, and consumer preferences. The above figure shows the importance of given factors for the consumer of sweet and savory snacks. Taste variety and quality are extremely important factors for the consumer while quantity and price are important factors for the consumer. There are several consumers who do not give importance to the packaging, variety, and price as they focus on the taste and quality.

Among the regions, North America dominates the global sweet and savory snacks market. It holds more than 30% market share of the global sweet and savory snacks market. The U.S. is the largest consumer of sweet and savory snacks as it holds approximately 20% market share of the global sweet and savory snacks market? The high disposable income of consumers due to modernization and widening base of working personnel is primary growth stimulants for the North America sweet and savory snacks market. Europe is a second-largest market for sweet and savory snacks followed by the Asia Pacific. Factors attributable to the growth of the European snack products are the evolving lifestyle and changing dietary habits in this region.

Market Dynamics

Drivers

Restraints

Opportunities

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/p8ffgs

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Global Sweet and Savory Snacks Market to 2026 - Key Drivers, Restraints and Opportunities - ResearchAndMarkets.com - Business Wire

Easy Ways To Help Improve Your Health – Anti Aging News

This is the season that invites us to eat a little bit lighter and become more active outdoors with its brighter, longer, and warmer days trying their best to invoke sun shiny happiness inspiration in us all.

For those looking to engage in a more healthful lifestyle that is perhaps in a reaction to a few pounds or less desirable habits that have been gained over the past few difficult months, please be kind to yourself. We may have indulged a bit more but this is due to the stresses that are associated with being stuck at home and all of the uncertainty. It is important not to judge yourself or others for the ways chosen to cope during such a trying and uncertain time.

Being kind and compassionate to others and ourselves is important to mental health, and this can also affect our future behaviors. Forget what you did before, consider each day from now on to be a new opportunity to improve your health and wellness by making a few very simple adjustments to your daily routines to support your overall health, longevity, and anti-aging efforts.

Along with the possibility of beautiful weather we also have the opportune time to take advantage of a variety of fresh produce that can be incorporated into healthy meals while we enjoy a variety of outdoor locations that can be utilized for fun fitness activities.

During the hotter weather it is especially important to stay hydrated because we may lose more fluids through sweat, drinking water will help to keep us healthy. The amount of water one needs can vary from person to person, but the Institute of Medicine recommends women should intake 2.7 liter of fluids per day and men should intake about 3.7 liter per day.

Drinking 12 ounces of water with each meal can help you meet your fluid needs, this can also help you to avoid overeating. For those that are not interested in plain water try adding fruit to the water to infuse some flavor or even some mint or rosemary. Seltzer can also be refreshing and more satisfying than plain water on a really hot day. Broth based soup can also help you to meet your fluid needs, as can water rich foods like watermelon, cucumbers, celery, oranges, and grapes among others.

Try to take advantage of the glorious weather and get outside and have some fitness fun. Regular physical activity can help to strengthen your bones and muscles while lowering your risks for disease and helping you to maintain a healthy weight.

Exercise does not have to be boring and tedious, take advantage of these longer days to enjoy activities like treasure hunting, walking, hiking, dancing, jogging, riding a bike, roller skating, swimming, tennis, badminton, outdoor yoga, golf, frisbee, bocce ball, volleyball, snorkeling, horseshoes, baseball, soccer, lawn bowling, golf, paddle boarding, kayaking, flying a kite, and water skiing. This season has numerous ways to have fun which will help to keep you fit and increase your energy expenditure including chores like mowing the lawn, gardening, yard work and washing the car which also get you moving more while accomplishing the necessary chores.

If you consume a lot of carbs you can also consider replacing some of the more starchy ones like white rice and regular pasta with lower carb alternatives as a compromise that can give your meals a nutritional upgrade by boosting the fiber and nutrients while reducing some calories. You can try switching out mashed potatoes for cauliflower sometimes, or substitutes chickpeas and lentil pasta in the place of regular pasta. Chickpea rice makes a nice alternative to white rice as does quinoa, and for another touch of variety spaghetti squash makes a nice change from regular spaghetti noodles.

Adding protein to a meal can help to make us feel fuller for longer, and it also helps us to intake fewer calories than a meal that consists of only fats and carbohydrates. Protein can also help to preserve muscle mass which in turn helps to keep our metabolism running which is important as we lose muscle mass with age. Protein rich food such as shellfish, poultry, beans, lentils, eggs, Greek yogurt, and fish are good choices, but dont forget to add some veggies to that meal to increase satiety to complete that meal.

Sometimes I find it hard to eat protein when it is hot out, during these times I turn to quinoa which can be consumed hot or cold, and it is also a good source of plant based protein for those who wish to avoid animal products. Cooked quinoa consists of 222 calories 71.6% water, 21.3% carbs, 4.4% protein, and 1.92% fat in just one cup. Additionally it is gluten free and higher in nutrients than most grains, while being very flexible in its uses which is why it is my preferred go to for a variety of yummy hot/cold recipes.

For anyone looking for that magic bullet, fiber may be as close as it gets as this undigested plant substance can help you to feel full, lose weight, ease digestion, lower cholesterol levels, and help you to lower the risks of developing heart disease, type 2 diabetes, and colorectal cancer. However, most people (9 out of 10) are not getting enough fiber according to research.

To get more fiber into your diet isnt that hard, barley, oatmeal, beans, nuts, legumes, seeds, fruits and veggies are all great sources. Typically the more whole, natural and unprocessed the food the higher in fiber it will be, but keep in mind that there is no fiber in meat, dairy, or sugar. One of the benefits of eating more fruits and vegetables is boosting your immune system to go along with increasing your fiber intake. It is recommended that at mealtimes you fill half of your plate with fruits and veggies, which come in a range of colors carrying a variety of important vitamins, minerals, and nutrients that can help to prevent disease. Think Eat The Rainbow at meal times.

In addition to keeping an eye on how much you are eating, it may also wise to pick a time that you will stop eating at for the day as well, which should be ideally at least 4 before going to bed to result in at least 12 hours between meals. This habit offers you a way to enjoy some of the benefits of intermittent fasting that works with our natural circadian rhythms. Eating late at night may increase the likelihood of weight gain, while taking in calories during the day has beneficial effects on weight management as well as other health indicators. If you find yourself getting hungry, reach for a glass of water which should help to fill that hole.

You dont have to eliminate all indulgences, just pick one for the day. It can be that glass of wine with dinner, that cup of low fat ice cream, or even a small handful of dark chocolate chips. The point is that in moderation intentional portion controlled indulgences, even on a daily basis, can be part of a healthy plan. It is not realistic to deprive yourself of all of your favorite treats, and it may be setting yourself up to backfire and binge on those forbidden foods when you least expect it which will sabotage all your efforts.

Along the way in your journey you may experience slips and setbacks. Be kind to yourself, no one is perfect. The important part is that you are trying. This is not a failure, it is just a minor speed bump. Take it as an opportunity to learn and grow from. Pick yourself up and start over again. Do not give up, you can do this, and you are well worth it. You deserve the benefits that each day of lifestyle improvement will bring to you.

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Easy Ways To Help Improve Your Health - Anti Aging News