Wiring the Quantum Computer of the Future: aNovel Simple Build with Existing Technology – Analytics Insight

Wiring the Quantum Computer of the Future: a Novel Simple Build with Existing Technology

The basic units of a quantum computer can be rearranged in 2D to solve typical design and operation challenges

Efficient quantum computing is expected to enable advancements that are impossible with classical computers. Scientists from Japan and Sydney have collaborated and proposed a novel two-dimensional design that can be constructed using existing integrated circuit technology. This design solves typical problems facing the current three-dimensional packaging for scaled-up quantum computers, bringing the future one step closer.

Quantum computing is increasingly becoming the focus of scientists in fields such as physics and chemistry,and industrialists in the pharmaceutical, airplane, and automobile industries. Globally, research labs at companies like Google and IBM are spending extensive resources on improving quantum computers, and with good reason. Quantum computers use the fundamentals of quantum mechanics to process significantly greater amounts of information much faster than classical computers. It is expected that when error-corrected and fault-tolerant quantum computation is achieved, scientific and technological advancement will occur at an unprecedented scale.

But, building quantum computers for large-scale computation is proving to be a challenge in terms of their architecture. The basic units of a quantum computer are the quantum bits or qubits. These are typically atoms, ions, photons, subatomic particles such as electrons,or even larger elements that simultaneously exist in multiple states, making it possible to obtain several potential outcomes rapidly for large volumes of data. The theoretical requirement for quantum computers is that these are arranged in two-dimensional (2D) arrays, where each qubit is both coupled with its nearest neighbor and connected to the necessary external control lines and devices. When the number of qubits in an array is increased, it becomes difficult to reach qubits in the interior of the array from the edge. The need to solve this problem has so far resulted in complex three-dimensional (3D) wiring systems across multiple planes in which many wires intersect,making their construction a significant engineering challenge.

A group of scientists from Tokyo University of Science, Japan, RIKEN Centre for Emergent Matter Science, Japan, and University of Technology, Sydney, led by Prof Jaw-Shen Tsai, proposes a unique solution to this qubit accessibility problem by modifying the architecture of the qubit array. Here, we solve this problem and present a modified superconducting micro-architecture that does not require any 3D external line technology and reverts to a completely planar design, they say. This study has been published in the New Journal of Physics.

The scientists began with a qubit square lattice array and stretched out each column in the 2D plane. They then folded each successive column on top of each other, forming a dual one-dimensional array called a bi-linear array. This put all qubits on the edge and simplified the arrangement of the required wiring system.The system is also completely in 2D. In this new architecture, some of the inter-qubit wiringeach qubit is also connected to all adjacent qubits in an arraydoes overlap, but because these are the only overlaps in the wiring, simple local 3D systems such as airbridges at the point of overlap are enough and the system overall remains in 2D. As you can imagine, this simplifies its construction considerably.

The scientists evaluated the feasibility of this new arrangement through numerical and experimental evaluation in which they tested how much of a signal was retained before and after it passed through an airbridge. Results of both evaluations showed that it is possible to build and run this system using existing technology and without any 3D arrangement.

The scientists experiments also showed them that their architecture solves several problems that plague the 3D structures: they are difficult to construct, there is crosstalk or signal interference between waves transmitted across two wires, and the fragile quantum states of the qubits can degrade. The novel pseudo-2D design reduces the number of times wires cross each other,thereby reducing the crosstalk and consequently increasing the efficiency of the system.

At a time when large labs worldwide are attempting to find ways to buildlarge-scale fault-tolerant quantum computers, the findingsof this exciting new study indicate that such computers can be built using existing 2D integrated circuit technology. The quantum computer is an information device expected to far exceed the capabilities of modern computers, Prof Tsai states.The research journey in this direction has only begun with this study, and Prof Tsai concludes by saying, We are planning to construct a small-scale circuit to further examine and explore the possibility.

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ReferenceTitle of original paper: Pseudo-2D superconducting quantum computing circuit for the surface code: the proposal and preliminary tests

Journal:New Journal of Physics

DOI:10.1088/1367-2630/ab7d7d

Tokyo University of Science (TUS) is a well-known and respected university, and the largest science-specialized private research university in Japan, with four campuses in central Tokyo and its suburbs and in Hokkaido. Established in 1881, the university has continually contributed to Japans development in science through inculcating the love for science in researchers, technicians, and educators.

With a mission of Creating science and technology for the harmonious development of nature, human beings, and society, TUS has undertaken a wide range of research from basic to applied science. TUS has embraced a multidisciplinary approach to research and undertaken intensive study in some of todays most vital fields. TUS is a meritocracy where the best in science is recognized and nurtured. It is the only private university in Japan that has produced a Nobel Prize winner and the only private university in Asia to produce Nobel Prize winners within the natural sciences field.

Website:https://www.tus.ac.jp/en/mediarelations/

Dr Jaw-Shen Tsai is currently a Professor at the Tokyo University of Science, Japan. He began research in Physics in 1975 and continues to hold interest in areas such as superconductivity, the Josephson effect, quantum physics, coherence, qubits, and artificial atoms. He has 160+ research publications to his credit and serves as the lead author in this paper. He has also won several awards, including Japans Medal of Honor, the Purple Ribbon Award.

Professor Jaw-Shen Tsai

Department of Physics

Tokyo University of Science

Tsutomu Shimizu

Public Relations Divisions

Tokyo University of Science

Email: mediaoffice@admin.tus.ac.jp

Website: https://www.tus.ac.jp/en/mediarelations/

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Wiring the Quantum Computer of the Future: aNovel Simple Build with Existing Technology - Analytics Insight

Eleven Princeton faculty elected to American Academy of Arts and Sciences – Princeton University

Princeton faculty members Rubn Gallo, M. Zahid Hasan, Amaney Jamal, Ruby Lee, Margaret Martonosi, Tom Muir, Eve Ostriker, Alexander Smits, Leeat Yariv and Muhammad Qasim Zaman have been named members of the American Academy of Arts and Sciences. Visiting faculty member Alondra Nelson also was elected to the academy.

They are among 276 scholars, scientists, artists and leaders in the public, nonprofit and private sectors elected this year in recognition of their contributions to their respective fields.

Gallo is the Walter S. Carpenter, Jr., Professor in Language, Literature, and Civilization of Spain and a professor of Spanish and Portuguese. He joined the Princeton faculty in 2002. His most recent book is Conversacin en Princeton(2017)with Mario Vargas Llosa, who was teaching at Princeton when he received the Nobel Prize in Literature in 2010.

Gallos other books include Prousts LatinAmericans(2014);Freuds Mexico: Into the Wilds of Psychoanalysis(2010); Mexican Modernity: the Avant-Garde and the Technological Revolution(2005); New Tendencies in Mexican Art(2004); andThe Mexico City Reader(2004). He is currently working on Cuba: A New Era, a book about the changes in Cuban culture after the diplomatic thaw with the United States.

Gallo received the Gradiva award for the best book on a psychoanalytic theme and the Modern Language Associations Katherine Singer Kovacs Prize for the best book on a Latin American topic. He is a member of the board of the Sigmund Freud Museum in Vienna, where he also serves as research director.

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Nick Barberio, Office of Communications

Hasan is the Eugene Higgins Professor of Physics. He studiesfundamental quantum effects in exotic superconductors, topological insulators and quantum magnetsto make new discoveries about the nature of matter, work that may have future applications in areas such asquantum computing. He joined the faculty in 2002and has since led his research team to publish many influential findings.

Last year, Hasans lab led research that discovered that certain classes of crystals with an asymmetry like biological handedness, known as chiral crystals, may harbor electrons that behave in unexpected ways. In 2015, he led a research team that first observed Weyl fermions, which, if applied to next-generation electronics, could allow for a nearly free and efficient flow of electricity in electronics, and thus greater power, especially for computers.

In 2013, Hasan was named a fellow of the American Physical Society for the experimental discovery of three-dimensional topological insulators a new kind of quantum matter. In 2009, he received a Sloan Research Fellowship for groundbreaking research.

Photo by Tori Repp/Fotobuddy

Jamal is the Edwards S. Sanford Professor of Politics and director of the Mamdouha S. Bobst Center for Peace and Justice. She has taught at Princeton since 2003. Her current research focuses on the drivers of political behavior in the Arab world, Muslim immigration to the U.S. and Europe, and the effect of inequality and poverty on political outcomes.

Jamal also directs the Workshop on Arab Political Development and the Bobst-AUB Collaborative Initiative. She is also principal investigator for the Arab Barometer project, which measures public opinion in the Arab world. She is the former President of the Association of Middle East Womens Studies.

Her books include Barriers to Democracy (2007), which won the 2008 APSA Best Book Award in comparative democratization, and Of Empires and Citizens, which was published by Princeton University Press (2012). She is co-editor of Race and Arab Americans Before and After 9/11: From Invisible Citizens to Visible Subjects (2007) and Citizenship and Crisis: Arab Detroit after 9/11 (2009).

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Lee is the Forrest G. Hamrick Professor in Engineering and professor of electrical engineering. She is an associated faculty member in computer science. Lee joined the Princeton faculty in 1998.Her work at Princeton explores how the security and performance of computing systems can be significantly and simultaneously improved by hardware architecture. Her designs of secure processor architectures have strongly influenced industry security offerings and also inspired new generations of academic researchers in hardware security, side-channel attacks and defenses, secure processors and caches, and enhanced cloud computing and smartphone security.

Her research lies at the intersection of computer architecture, cybersecurity and, more recently, the branch of artificial intelligence known as deep learning.

Lee spent 17 years designing computers at Hewlett-Packard, and was a chief architect there before coming to Princeton. Among many achievements, Lee is known in the computer industry for her design of the HP Precision Architecture (HPPA or PA-RISC) that powered HPs commercial and technical computer product families for several decades, and was widely regarded as introducing key forward-looking features. In the '90s she spearheaded the development of microprocessor instructions for accelerating multimedia, which enabled video and audio streaming, leading to ubiquitous digital media.Lee is a fellow into the Association for Computing Machinery and the Institute of Electrical and Electronics Engineers.

Margaret Martonosi, the Hugh Trumbull Adams 35 Professor of Computer Science, specializes in computer architecture and mobile computing with an emphasis on power efficiency. She was one of the architects of the Wattch power modeling infrastructure, a tool that was among the first to allow computer scientists to incorporate power consumption into early-stage computer systems design. Her work helped demonstrate that power needs can help dictate the design of computing systems. More recently, Martonosis work has also focused on architecture and compiler issues in quantum computing.

She currently serves as head of the National Science Foundations Directorate for Computer and Information Science and Engineering, one of seven top-level divisions within the NSF. From 2017 until February 2020, she directed Princetons Keller Center for Innovation in Engineering Education, a center focused on enabling students across the University to realize their aspirations for addressing societal problems. She is an inventor who holds seven U.S. patents and has co-authored two technical reference books on power-aware computer architecture. In 2018, she was one of 13 co-authors of a National Academies consensus study report on progress and challenges in quantum computing.

Martonosi is a fellow of the Association for Computing Machinery (ACM) and the Institute of Electrical and Electronics Engineers IEEE). Among other honors, she has received a Jefferson Science Fellowship, the IEEE Technical Achievement Award, and the ACM SIGARCH Alan D. Berenbaum Distinguished Service Award. She joined the Princeton faculty in 1994.

Muir is the Van Zandt Williams, Jr. Class of 65 Professor of Chemistry and chair of the chemistry department. He joined Princeton in 2011 and is also an associated faculty member in molecular biology.

He leads research in investigating the physiochemical basis of protein function in complex systems of biomedical interest. By combining tools of organic chemistry, biochemistry, biophysics and cell biology, his lab has developed a suite of new technologies that provide fundamental insight into how proteins work. The chemistry-driven approaches pioneered by Muirs lab are now widely used by chemical biologists around the world.

Muir has published over 150 scientific articles and has won a number of honors for his research.He received a MERIT Award from the National Institutes of Health and is a fellow of American Association for the Advancement of Science and the Royal Society of Edinburgh.

Nelson is the Harold F. Linder Chair in the School of Social Science at the Institute for Advanced Study and a visiting lecturer with the rank of professor in sociology at Princeton. She is president of the Social Science Research Council and is one of the country's foremost thinkers in the fields of science, technology, social inequalityand race. Her groundbreaking books include "The Social Life of DNA: Race, Reparations, and Reconciliation after the Genome" (2016) and "Body and Soul: The Black Panther Party and the Fight Against Medical Discrimination" (2011).Her other books include"Genetics and the Unsettled Past: The Collision of DNA, Race, and History" (with Keith Wailoo of Princeton and Catherine Lee) and"Technicolor: Race, Technology, and Everyday Life" (with Thuy Linh Tu). In 2002 she edited "Afrofuturism," a special issue of Social Text.

Nelson's writings and commentary also have reached the broader public through a variety of outlets. She has contributed to national policy discussions on inequality and the implications of new technology on society.

She is an elected fellow of the American Academy of Political and Social Science, the Hastings Centerand the Sociological Research Association. She serves on several advisory boards, including the Andrew. W. Mellon Foundation and the American Association for the Advancement of Science.

Ostriker, professor of astrophysical sciences, studies the universe. Her research is in the area of theoretical and computational astrophysics, and the tools she uses are powerful supercomputers and algorithms capable of simulating the birth, life, death and reincarnation of stars in their galactic homes. Ostriker and her fellow researchers build computer models using fundamental physical laws ones that govern gravity, fluid dynamics and electromagnetic radiation to follow the evolution of conditions found in deep space.

Ostriker, who came to Princeton in 2012, and her team have explored the formation of superbubbles, giant fronts of hot gas that billow out from a cluster of supernova explosions. More recently, she and her colleagues turned their focus toward interstellar clouds.

The research team uses computing resources through the Princeton Institute for Computational Science and Engineering and its TIGER and Perseus research computing clusters, as well as supercomputers administered through NASA. In 2017, Ostriker received a Simons Investigator Award.

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Nick Donnoli, Office of Communications

Smits is the Eugene Higgins Professor of Mechanical and Aerospace Engineering, Emeritus. His research spans the field of fluid mechanics, including fundamental turbulence, supersonic and hypersonic flows, bio-inspired flows, sports aerodynamics, and novel energy-harvesting concepts.

He joined the Princeton faculty in 1981 and transferred to emeritus status in 2018. Smits served as chair of the Department of Mechanical and Aerospace Engineering for 13 years and was director of the Gas Dynamics Laboratory on the Forrestal Campus for 33 years. During that time, he received several teaching awards, including the Presidents Award for Distinguished Teaching.

Smits has written more than 240 articles and three books, and edited seven volumes. He was awarded seven patents and helped found three companies. He is a member of the National Academy of Engineering and a fellow of the American Physical Society, the American Institute of Aeronautics and Astronautics, the American Society of Mechanical Engineers, the American Association for the Advancement of Science, and the Australasian Fluid Mechanics Society.

Yariv is the Uwe Reinhardt Professor of Economics. An expert in applied theory and experimental economics, her research interests concentrate on game theory, political economy, psychology and economics. She joined the faculty in 2018. Yariv also is director of the Princeton Experimental Laboratory for the Social Sciences.

She is a member of several professional organizations and is lead editor of American Economic Journal: Microeconomics, a research associate with the Political Economy Program of the National Bureau of Economic Research, and a research fellow with the Industrial Organization Programme of the Centre for Economic Policy Research.

She is also a fellow of the Econometric Society and the Society for the Advancement of Economic Theory, and has received numerous grants for researchand awards for her many publications.

Zaman, who joined the Princeton faculty in 2006, is the Robert H. Niehaus 77 Professor of Near Eastern Studies and Religion and chair of the Department of Near Eastern Studies.

He has written on the relationship between religious and political institutions in medieval and modern Islam, on social and legal thought in the modern Muslim world, on institutions and traditions of learning in Islam, and on the flow of ideas between South Asia and the Arab Middle East. He is the author of Religion and Politics under the Early Abbasids (1997), The Ulama in Contemporary Islam: Custodians of Change (2002), Ashraf Ali Thanawi: Islam in Modern South Asia (2008), Modern Islamic Thought in a Radical Age: Religious Authority and Internal Criticism (2012), and Islam in Pakistan: A History (2018). With Robert W. Hefner, he is also the co-editor of Schooling Islam: The Culture and Politics of Modern Muslim Education (2007); with Roxanne L. Euben, of Princeton Readings in Islamist Thought (2009); and, as associate editor, with Gerhard Bowering et al., of the Princeton Encyclopedia of Islamic Political Thought (2013). Among his current projects is a book on South Asia and the wider Muslim world in the 18th and 19th centuries.

In 2017, Zaman received Princetons Graduate Mentoring Award. In 2009, he received a Guggenheim Fellowship.

The mission of the academy: Founded in 1780, the American Academy of Arts and Sciences honors excellence and convenes leaders from every field of human endeavor to examine new ideas, address issues of importance to the nation and the world, and work together to cultivate every art and science which may tend to advance the interest, honor, dignity, and happiness of a free, independent, and virtuous people.

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Eleven Princeton faculty elected to American Academy of Arts and Sciences - Princeton University

RMACC’s 10th High Performance Computing Symposium to Be Held Free Online – HPCwire

BOULDER, Colo., April 22, 2020 The Rocky Mountain Advanced Computing Consortium (RMACC) will hold its 10thannual High Performance Computing Symposium as a multi-track on-line version on May 20-21.Registration for the event will be free to all who would like to attend.

The on-line Symposium will include presentations by two keynote speakers and a full slate of tutorial sessions.Another longtime Symposium tradition a poster competition for students to showcase their own research also will be continued. Competition winners will receive an all-expenses paid trip to SC20 in Atlanta.

Major sponsor support is being provided by Intel, Dell and HPE with additional support from ARM, IBM, Lenovo and Silicon Mechanics.

Links to the Symposium registration, its schedule, and how to enter the poster competition can be found atwww.rmacc.org/hpcsymposium.

The Keynote speakers areDr.Nick Bronn, a Research Staff Member in IBMs Experimental Quantum Computing group, andDr. Jason Dexter, a working group coordinator for the groundbreaking black hole imaging studies published by Event Horizon Telescope.

Dr. Bronn serves at IBMs TJ Watson Research Center in Yorktown Heights, NY.He has been responsible for qubit (quantum bits) device design, packaging, and cryogenic measurement, working towards scaling up larger numbers of qubits on a device and integration with novel implementations of microwave and cryogenic hardware.He will speak on the topic,Benchmarking and Enabling Noisy Near-term Quantum Hardware.

Dr.Dexter is a member of the astrophysical and planetary sciences faculty at the University of Colorado Boulder.He will speak on the role of high performance computing in understanding what we see in the first image of a black hole.Dr. Dexter is a member of both the Event Horizon Telescope and VLTI/GRAVITY collaborations, which can now image black holes.

Their appearances along with the many tutorial sessions continue the RMACCs annual tradition of showcasing cutting-edge HPC achievements in both education and industry.

The largest consortium of its kind, the RMACC is a collaboration among 30 academic and government research institutions in Arizona, Colorado, Idaho, Montana, Nevada, New Mexico, Utah, Washington and Wyoming. The consortiums mission is to facilitate widespread effective use of high performance computing throughout the 9-state intermountain region.

More about the RMACC and its mission can be found at the website:www.rmacc.org.

About RMACC

Primarily a volunteer organization, the RMACC is collaboration among 30 academic and research institutions located in Arizona, Colorado, Idaho, Montana, Nevada, New Mexico, Utah, Washington and Wyoming.The RMACCs mission is to facilitate widespread effective use of high performance computing throughout this 9-state intermountain region.

Source: RMACC

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RMACC's 10th High Performance Computing Symposium to Be Held Free Online - HPCwire

Advanced Encryption Standard (AES): What It Is and How It Works – Hashed Out by The SSL Store – Hashed Out by The SSL Store

Understanding advanced encryption standard on basic level doesnt require a higher degree in computer science or Matrix-level consciousness lets break AES encryption down into laymans terms

Hey, all. We know of security of information to be a hot topic since, well, forever. We entrust our personal and sensitive information to lots of major entities and still have problems with data breaches, data leaks, etc. Some of this happens because of security protocols in networking, or bad practices of authentication management but, really, there are many ways that data breaches can occur. However, the actual process of decrypting a ciphertext without a key is far more difficult. For that, we can thank the encrypting algorithms like the popular advanced encryption standard and the secure keys that scramble our data into indecipherable gibberish.

Lets look into how AES works and different applications for it. Well be getting a little into some Matrix-based math so, grab your red pills and see how far this rabbit hole goes.

Lets hash it out.

You may have heard of advanced encryption standard, or AES for short but may not know the answer to the question what is AES? Here are four things you need to know about AES:

The National Institute of Standards and Technology (NIST) established AES as an encryption standard nearly 20 years ago to replace the aging data encryption standard (DES). After all, AES encryption keys can go up to 256 bits, whereas DES stopped at just 56 bits. NIST could have chosen a cipher that offered greater security, but the tradeoff would have required greater overhead that wouldnt be practical. So, they went with one that had great all-around performance and security.

AESs results are so successful that many entities and agencies have approved it and utilize it for encrypting sensitive information. The National Security Agency (NSA), as well as other governmental bodies, utilize AES encryption and keys to protect classified or other sensitive information. Furthermore, AES is often included in commercial based products, including but limited to:

Although it wouldnt literally take forever, it would take far longer than any of our lifetimes to crack an AES 256-bit encryption key using modern computing technology. This is from a brute force standpoint, as in trying every combination until we hear the click/unlocking sound. Certain protections are put in place to prevent stuff from like this happening quickly, such as a limit on password attempts before a lockdown, which may or may not include a time lapse, to occur before trying again. When we are dealing with computation in milliseconds, waiting 20 minutes to try another five times would seriously add to the time taken to crack a key.

Just how long would it take? We are venturing into a thousand monkeys working on a thousand typewriters to write A Tale of Two Cities territory. The possible combinations for AES 256-bit encryption is 2256. Even if a computer can do multiple quadrillions of instructions per second, then we are still in that eagles-wings-eroding-Mount-Everest time frame.

Needless to say, its waaaaaaaaaaaaaaaaaaay (theres not enough memory on our computers to support the number of a letters that I want to convey) longer than our current universe has been in existence. And thats just for a 16-byte block of data. So, as you can see, brute forcing AES even if it is 128 bits AES is futile.

That would likely change, though, once quantum computing becomes a little more mainstream, available, and effective. Quantum computing is expected to break AES encryption and require other methods to protect our data but thats still a ways down the road.

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To better understand what AES is, you need to understand how it works. But in order to see how the advanced encryption standard actually works, however, we first need to look at how this is set up and the rules concerning the process based on the users selection of encryption strength. Typically, when we discuss using higher bit levels of security, were looking at things that are more secure and more difficult to break or hack. While the data blocks are broken up into 128 bits, the key size have a few varying lengths: 128 bits, 196 bits, and 256 bits. What does this mean? Lets back it up for a second here.

We know that encryption typically deals in the scrambling of information into something unreadable and an associated key to decrypt the scramble. AES scramble procedures use four scrambling operations in rounds, meaning that it will perform the operations, and then repeat the process based off of the previous rounds results X number of times. Simplistically, if we put in X and get out Y, that would be one round. We would then put Y through the paces and get out Z for round 2. Rinse and repeat until we have completed the specified number of rounds.

The AES key size, specified above, will determine the number of rounds that the procedure will execute. For example:

As mentioned, each round has four operations.

So, youve arrived this far. Now, you may be asking: why, oh why, didnt I take the blue pill?

Before we get to the operational parts of advanced encryption standard, lets look at how the data is structured. What we mean is that the data that the operations are performed upon is not left-to-right sequential as we normally think of it. Its stacked in a 44 matrix of 128 bits (16 bytes) per block in an array thats known as a state. A state looks something like this:

So, if your message was blue pill or red, it would look something like this:

So, just to be clear, this is just a 16-byte block so, this means that every group of 16 bytes in a file are arranged in such a fashion. At this point, the systematic scramble begins through the application of each AES encryption operation.

As mentioned earlier, once we have our data arrangement, there are certain linked operations that will perform the scramble on each state. The purpose here is to convert the plaintext data into ciphertext through the use of a secret key.

The four types of AES operations as follows (note: well get into the order of the operations in the next section):

As mentioned earlier, the key size determines the number of rounds of scrambling that will be performed. AES encryption uses the Rjindael Key Schedule, which derives the subkeys from the main key to perform the Key Expansion.

The AddRoundKey operation takes the current state of the data and executes the XOR Boolean operation against the current round subkey. XOR means Exclusively Or, which will yield a result of true if the inputs differ (e.g. one input must be 1 and the other input must be 0 to be true). There will be a unique subkey per round, plus one more (which will run at the end).

The SubBytes operation, which stands for substitute bytes, will take the 16-byte block and run it through an S-Box (substitution box) to produce an alternate value. Simply put, the operation will take a value and then replace it by spitting out another value.

The actual S-Box operation is a complicated process, but just know that its nearly impossible to decipher with conventional computing. Coupled with the rest of AES operations, it will do its job to effectively scramble and obfuscate the source data. The S in the white box in the image above represents the complex lookup table for the S-Box.

The ShiftRows operation is a little more straightforward and is easier to understand. Based off the arrangement of the data, the idea of ShiftRows is to move the positions of the data in their respective rows with wrapping. Remember, the data is arranged in a stacked arrangement and not left to right like most of us are used to reading. The image provided helps to visualize this operation.

The first row goes unchanged. The second row shifts the bytes to the left by one position with row wrap around. The third row shifts the bytes one position beyond that, moving the byte to the left by a total of two positions with row wrap around. Likewise, this means that the fourth row shifts the bytes to the left by a total of three positions with row wrap around.

The MixColumns operation, in a nutshell, is a linear transformation of the columns of the dataset. It uses matrix multiplication and bitwise XOR addition to output the results. The column data, which can be represented as a 41 matrix, will be multiplied against a 44 matrix in a format called the Gallois field, and set as an inverse of input and output. That will look something like the following:

As you can see, there are four bytes in that are ran against a 44 matrix. In this case, matrix multiplication has each input byte affecting each output byte and, obviously, yields the same size.

Now that we have a decent understanding of the different operations utilized to scramble our data via AES encryption, we can look at the order in which these operations execute. It will be as such:

Note: The MixColumns operation is not in the final round. Without getting into the actual math of this, theres no additional benefit to performing this operation. In fact, doing so would simply make the decryption process a bit more taxing in terms of overhead.

If we consider the number of rounds and the operations per round that are involved, by the end of it, you should have a nice scrambled block. And that is only a 16-byte block. Consider how much information that equates to in the big picture. Its miniscule when compared to todays file/packet sizes! So, if each 16-byte block has seemingly no discernable pattern at least, any pattern that can be deciphered in a timely manner Id say AES has done its job.

We know the advanced encryption standard algorithm itself is quite effective, but its level of effectiveness depends on how its implemented. Unlike the brute force attacks mentioned above, effective attacks are typically launched on the implementation and not on the algorithm itself. This can be equated to attacking users as in phishing attacks versus attacking the technology behind the service/function that may be hard to breach. These can be considered side-channel attacks where the attacks are being carried out on other aspects of the entire process and not the focal point of the security implementation.

While I always advocate going with a reasonable/effective security option, a lot of AES encryption is happening without you even knowing it. Its locking down spots of the computing world that would otherwise be wide open. In other words, there would be many more opportunities for hackers to capture data if advanced encryption standard wasnt implemented at all. We just need to know how to identify the open holes and figure out how to plug them. Some may be able to use AES and others may need another protocol or process.

Appreciate the encryption implementations we have, use the best ones when needed, and happy scrutinizing!

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Rare ‘killer’ mutations present at birth could be taking years off your life – Science Magazine

Mutations present in our DNA from birth can cause us to die at a younger age.

By Amanda HeidtApr. 24, 2020 , 12:40 PM

Scientists have discovered a handful of ultrarare mutations present in our cells from birth that likely shave years off a persons life. Each of these DNA variants, most likely inherited from our parents, can reduce life span by as much as 6 months, the researchers estimate. And different combinations can dictate how long people live before developing age-related diseases such as cancer, diabetes, and dementia.

A persons genes dont set a specific natural life spandiet and many other factors play large roles, toobut studies have shown that DNA variants can influence the aging process. Biologists chalk up less than one-third of that influence to the genes we inherit. The source of other age-influencing DNA variation is environmental: Sun damage, chemical exposure, and other insults that create thousands of random mutations. Each cells collection of these environmental mutations differs, and most dont greatly impact a persons life span.

Hunting for these rare mutations, which are found in less than one in every 10,000 people, required a group effort. Harvard University geneticist Vadim Gladyshev, a senior co-author in the new study, partnered with academic colleagues and a biotech company called Gero LLC to scour the UK Biobank, a public database containing the genotypes of about 500,000 volunteers.

Using more than 40,000 of these genotypes, the team looked for correlations between small changes in DNA and health conditions, a so-called genomewide association study. Specifically, the variants they were targeting knock out genes entirely, depriving all the cells in the body of certain proteins.

On average, each person is born with six ultrarare variants that can decrease life span and health span, the amount of time people live before developing serious diseases, the team reports this month in eLife. The more mutations, the more likely a person was to develop an age-related illness at a younger age or die. The exact combination matters, Gladyshev says, but in general, each mutation decreases life span by 6 months and health span by 2 months.

The results build on what is already known about aging: Family genes matter. But rather than studying the common mutations found in especially long-lived people, researchers can now target rarer variants present in everyone. Gladyshev hopes this information can be used in clinical trials to categorize participants by their mutations in addition to things like gender and actual age.

He admits the findings are potentially controversial, as they minimize the perceived contribution to aging of environmental somatic mutations acquired throughout life. Somatic mutations live in a larger universe of age-related changes influenced by lifestyle, he says, adding that changes to hormone and gene expression also come with age. They [all] contribute to the aging process, but on their own they do not cause it.

Jan Vijg, a geneticist at the Albert Einstein College of Medicine who studies the role of somatic mutations in aging, agrees, though he adds that somatic mutations can still cause diseases such as skin cancer that decrease life span.

Alexis Battle, a biomedical engineer at the Johns Hopkins University School of Medicine, points to an important caveat, however: The new research only looked at the exome, the 1% of the genome that actively builds the proteins that direct our cells. The rest is largely a black box, although growing evidence shows it can affect gene expression. Both Battle and Vijg agree that this DNA could be even more important in aging than the regions targeted by Gladyshev and his colleagues.

Going forward, Gladyshev would like to repeat his analysis on DNA from centenarians: those that live to be older than 100. Most of the previous research focused on what these people have that makes them long-lived, he says. But [we want to look at] the oppositeits what they dont have.

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Rare 'killer' mutations present at birth could be taking years off your life - Science Magazine

Risk of Recurrence of Triple-Negative Breast Cancer May be Predicted by Molecular Biomarkers – OncoZine

A study by researchers at the Johns Hopkins Kimmel Cancer Center and six other medical centers, inlcuding the University of Iowa and Duke University, have identified a set of molecular markers linked to a chemical process called methylation that may help predict the risk of cancer recurrence within five years for patients with triple-negative breast cancers (TNBC).[1]

Triple-negative breast cancer (TNBC), which lacks expression of the estrogen (ER), progesterone (PR), and HER2 receptors, is an aggressive type of breast cancer, accounting for up to 20% of all breast cancers with poorer survival rates than other types of breast cancer. [2] TNBC is diagnosed more frequently in younger and premenopausal women and is highly prevalent in African American and Hispanic women.[3]

Because of the absence of receptors seen in other forms of breast cancer, TNBC is unresponsive to the targeted hormonal and anti-HER2 therapies used to treat patients diagnosed with other breast cancers. Furthermore, one of the features of TNBC is that the most widely used gene expression profiling tests, including 21-gene Oncotype DX, the 70-gene Mammaprint, or the PAM50, have no clinical utility in patients with TNBC.

Overall, about one-quarter of these cancers recur within five years of localized treatment with surgery or radiation. Physicians currently lack accurate tools to identify which patients are at greatest risk of recurrence.

HypothesisIn the study, the researchers were able to confirm their hypothesis that higher levels of methylation* would be associated with earlier recurrence and worse outcomes for patients.

The finding did, however, not distinguish specific levels of methylation or specific methylation markers that could be used to personalize patient treatment, noted Christopher B. Umbricht, M.D., Ph.D., associate professor of surgery, oncology, and pathology at the Johns Hopkins University School of Medicine and a member of the Johns Hopkins Kimmel Cancer Center and the studys author.

In an article published in the January 31, 2020, issue of the journal npg Breast Cancer, Umbricht noted that their results may support physicians decisions to manage patients with less aggressive disease more conservatively and trigger earlier treatment for those with more aggressive disease.

StudyUmbricht and his colleagues examined breast cancer tissue from 110 triple-negative breast cancer (TNBC) patients from archival tissue repositories to look for the biological footprints of DNA methylation, an epigenetic process that can chemically silence genes that suppress tumors and has been well-documented across many types of cancer. The researchers observed that high methylation was associated with shorter recurrence-free interval

Based on these results they identified a set of such molecular markers in which higher levels of methylation were associated with a greater risk of a five-year recurrence of TNBC, confirming that their hypermethylation signatures identified increased recurrence risk independent of whether patients received chemotherapy.

Notes* Methylation refers to the addition of a methyl group (three hydrogen atoms bound to a carbon atom) to a DNA molecule.** Epigenetic process refers to the process where chemical compounds are added to genes to regulate their activity

Reference[1] Fackler MJ, Cho S, Cope L, et al. DNA methylation markers predict recurrence-free interval in triple-negative breast cancer. NPJ Breast Cancer. 2020;6:3. Published 2020 Jan 31. doi:10.1038/s41523-020-0145-3 [Article][2] Li CH, Karantza V, Aktan G, et al. Current treatment landscape for patients with locally recurrent inoperable or metastatic triple-negative breast cancer: a systematic literature review. Breast Cancer Res. 2019 Dec 16;21(1):143.[3] Wahba HA, El-Hadaad HA. Current approaches in treatment of triple-negative breast cancer. Cancer Biol Med. 2015 Jun;12(2):106-16.

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Risk of Recurrence of Triple-Negative Breast Cancer May be Predicted by Molecular Biomarkers - OncoZine

Healing the heart by returning it to its infancy – FierceBiotech

Nearly a decade ago, researchers at UT Southwestern Medical Center discovered that when mouse hearts were damaged in the first seven days of life, they would regenerate. They reasoned that if they could find a way to recreate that regenerative ability later in life, it might provide a new way to treat heart damage.

Now, that same team has discovered that a protein called calcineurin plays a key role in blocking the ability of heart muscle to regenerate after the first week of life. The discovery could be used to develop treatments that reverse this process, in essence returning the heart to its developmental stage, they reported in the journal Nature.

The discovery builds on previous work at UT Southwestern that focused on the protein Meis1, a transcription factor that prevents heart cells from dividing. When the researchers deleted the gene in mice that makes that protein, their cardiomyocytes continued to divide after the first week of life. But the effect was transient.

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RELATED: Stem cells don't repair injured hearts, but inflammation might, study finds

Then the researchers discovered that another protein called Hoxb13 was also key, because it shuttles Meis1 into the cell nucleus. So they deleted the genes for both Meis1 and Hoxb13 in adult mice to see what would happen after a heart attack.

It worked. The ability of the animals hearts to pump blood quickly returned to near-normal levels, they said. Even though the mice were adults, their hearts looked much like they would in animals that were still developing.

After a series of further experiments, the UT Southwestern scientists discovered that calcineurin regulates both Hoxb13 and Meis1. Inhibiting calcineurin prolongs the window of cardiomyocyte proliferation, they wrote in the study.

The idea of treating heart damage by turning back the clock isnt new. In fact, several research teams have tried using stem cells to repair damaged heart tissue. But those efforts have been disappointing so far.

Last year, a team from the Cincinnati Children's Hospital Medical Center tracked stem cells injected into the hearts of mice and concluded that it was not the cells themselves, but rather their ability to activate macrophage cells from the immune system that promoted healing. That led the researchers to suggest that efforts to regenerate the heart focus less on stem cells and more on other processes in the body that might promote healing.

The discovery of calcineurins role in regulating the regeneration of the heart is notable due to the fact that there are already drugs on the market that target the protein. Thats because calcineurin plays a role in a variety of diseases, including rheumatoid arthritis and diabetes. Testing these drugs, either individually or in combination, and developing new medicines that target calcineurin directly could offer new strategies for repairing hearts damaged by heart attacks, high blood pressure, viruses and more, suggested co-author Hesham Sadek, M.D., Ph.D., a professor of internal medicine, molecular biology and biophysics at UT Southwestern.

"By building up the story of the fundamental mechanisms of heart cell division and what blocks it, Sadek said in a statement, we are now significantly closer to being able to harness these pathways to save lives.

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Healing the heart by returning it to its infancy - FierceBiotech

UW president, biochemistry chair and mathematics professor named to American Academy of Arts and Sciences – UW News

Administrative affairs | For UW employees | Honors and awards | News releases | UW and the community

April 23, 2020

Three University of Washington faculty members, including President Ana Mari Cauce, are among the 2020 fellows of the American Academy of Arts and Sciences, one of the nations oldest and most prestigious honorary societies. Trisha Davis, professor and chair of biochemistry at the UW School of Medicine, and Tatiana Toro, the Craig McKibben and Sarah Merner Professor of Mathematics, are also among the 276 artists, scholars, scientists, and leaders in the public, non-profit and private sectors who were announced as new fellows Thursday.

We congratulate these incoming members of the Academy for excelling in a broad array of fields; we want to celebrate them and learn from them, said Nancy C. Andrews, chair of the Board of Directors of the American Academy. When Academy members come together, bringing their expertise and insights to our work, they help develop new insights and potential solutions for some of the most complex challenges we face.

Cauce who was named to the Educational and Academic Leadership section of the Academys Public Affairs, Business and Administration class became the 33rd president of the UW on Oct. 13, 2015 after serving as interim president for seven months and having previously served as provost and executive vice president.

Throughout her career, Cauce has championed access to higher education, including through the Husky Promise, which provides full tuition to eligible Washington students who otherwise could not attend college. As part of her strong belief in ensuring access to higher education for all, just one month into her role as interim president she engaged students in an honest discussion about race and equity, launching an effort to create a more just and diverse community.

Cauce is a professor of Psychology and American Ethnic Studies, with secondary appointments in the Department of Gender, Women and Sexuality Studies and the College of Education. She maintains an active research program, focusing on adolescent development, with a special emphasis on at-risk youth. She is also a strong advocate for women and underrepresented minorities to pursue careers in science, technology, engineering and mathematics.

Davis was named to the Cellular and Developmental Biology (including Genetics), Microbiology and Immunology Section of the Biological Sciences Class of the Academy. Davis and her colleagues explore the dynamics of the chromosome capture that occurs in preparation for cell division.

Impressive molecular machinery tries to assure that each cell resulting from the split receives a proper set of chromosomes. Mistakes in sorting, separating and distributing the chromosomes could cause serious problems, such as cancer. Davis team looks at how the movement and segregation of chromosomes is orchestrated. This chromosome assembly is trial and error, but cells usually can find and fix mistakes. As chromosomes attach to the separation machinery, checkpoints tune into to the connection and the tension it produces. If this quality assurance detects that a chromosome is incorrectly captured, it is released for another try.

The Davis lab uses many ways of examining this and related controls. These include genetic analysis, proteomics, quantitative microscopy, computational modeling and biochemical assays.

Davis holds the Earl W. Davie/ZymoGenetics Chair in Biochemistry at UW Medicine. She also heads the UWs Yeast Resource Center, funded by the National Institutes of Health to develop technologies for exploring protein structure and function.

Toro was named to the Mathematics, Applied Mathematics and Statistics section of the Academys Mathematical and Physical Sciences class. Her research centers on the premise that objects, which may at first appear irregular or disordered, actually have regular features that are quantifiable. Toros work spans geometric measure theory, harmonic analysis and partial differential equations. Toro studies the mathematical questions that come up in systems where the known data are rough, as well as interfaces that arise in noisy minimization problems.

In addition to her research, Toro has also worked to increase diversity in mathematics. She helped launch Latinx in the Mathematical Sciences, including two conferences through the National Science Foundation highlighting the achievements of Latinx mathematicians.

Toro joined the UW faculty in 1996 and her career includes numerous honors and accolades. Last year, she received the UWs Marsha L. Landolt Distinguished Graduate Mentor Award. In 2017, she was elected as a Fellow of the American Mathematical Society. Toro has also been a Guggenheim Fellow, an Alfred P. Sloan Research Fellow and a Simons Foundation Fellow.

Founded in 1780, the American Academy of Arts and Sciences is one of the countrys oldest learned societies and independent policy research centers, convening leaders from the academic, business and government sectors to respond to the challenges facing the nation and the world.

The new members join the company of Academy members elected before them, including Benjamin Franklin and Alexander Hamilton in the eighteenth century; Ralph Waldo Emerson and Maria Mitchell in the nineteenth; and Robert Frost, Martha Graham, Margaret Mead, Milton Friedman, and Martin Luther King, Jr. in the twentieth.

Learn more about the Academys mission, members, and work on its website amacad.org.

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UW president, biochemistry chair and mathematics professor named to American Academy of Arts and Sciences - UW News

Biochemistry Analyzer Market 2020: Opportunities in Grooming Regions EMD Millipore Corporation, BD, Bio-Rad Laboratories and Others – Cole of Duty

Futuristic Reports, The growth and development of Global Biochemistry Analyzer Market Report 2020 by Players, Regions, Type, and Application, forecast to 2026 provides industry analysis and forecast from 2020-2026. Global Biochemistry Analyzer Market analysis delivers important insights and provides a competitive and useful advantage to the pursuers. Biochemistry Analyzer processes, economic growth is analyzed as well. The data chart is also backed up by using statistical tools.

Simultaneously, we classify different Biochemistry Analyzer markets based on their definitions. Downstream consumers and upstream materials scrutiny are also carried out. Each segment includes an in-depth explanation of the factors that are useful to drive and restrain it.

Key Players Mentioned in the study are EMD Millipore Corporation, BD, Bio-Rad Laboratories, Roche, Takara Bio, Thermo Fisher Scientific, Abbott, GE Healthcare, Agilent Technologies, Sigma-Aldrich, Beckman Coulter/Danaher, QIAGEN

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Key Issues Addressed by Biochemistry Analyzer Market: It is very significant to have Biochemistry Analyzer segmentation analysis to figure out the essential factors of growth and development of the market in a particular sector. The Biochemistry Analyzer report offers well summarized and reliable information about every segment of growth, development, production, demand, types, application of the specific product which will be useful for players to focus and highlight on.

Businesses Segmentation of Biochemistry Analyzer Market:

On the basis on the applications, this report focuses on the status and Biochemistry Analyzer outlook for major applications/end users, sales volume, and growth rate for each application, including-

Research Molecular Biotechnology Human Immunology Genetics Diagnosis Biosciences Education

On the basis of types/products, this Biochemistry Analyzer report displays the revenue (Million USD), product price, market share, and growth rate of each type, split into-

Type 1 Type 2 Type 3 Type 4 Type 5

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NOTE: Our team is studying Covid-19 impact analysis on various industry verticals and Country Level impact for a better analysis of markets and industries. The 2020 latest edition of this report is entitled to provide additional commentary on latest scenario, economic slowdown and COVID-19 impact on overall industry. Further it will also provide qualitative information about when industry could come back on track and what possible measures industry players are taking to deal with current situation.

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You just drop an Email to:[emailprotected] us if you are looking for any Economical shift towards the New Normal on any Country or Industry Verticals.

Biochemistry Analyzer Market Regional Analysis Includes:

Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia) Europe (Turkey, Germany, Russia UK, Italy, France, etc.) North America (the United States, Mexico, and Canada.) South America (Brazil etc.) The Middle East and Africa (GCC Countries and Egypt.)

Biochemistry Analyzer Insights that Study is going to provide:

Gain perceptive study of this current Biochemistry Analyzer sector and also possess a comprehension of the industry; Describe the Biochemistry Analyzer advancements, key issues, and methods to moderate the advancement threats; Competitors In this chapter, leading players are studied with respect to their company profile, product portfolio, capacity, price, cost, and revenue. A separate chapter on Biochemistry Analyzer market structure to gain insights on Leaders confrontational towards market [Merger and Acquisition / Recent Investment and Key Developments] Patent Analysis** Number of patents filed in recent years.

Table of Content:

Global Biochemistry Analyzer Market Size, Status and Forecast 20261. Market Introduction and Market Overview2. Industry Chain Analysis3. Biochemistry Analyzer Market, by Type4. Biochemistry Analyzer Market, by Application5. Production, Value ($) by Regions6. Production, Consumption, Export, Import by Regions (2016-2020)7. Market Status and SWOT Analysis by Regions (Sales Point)8. Competitive Landscape9. Analysis and Forecast by Type and Application10. Channel Analysis11. New Project Feasibility Analysis12. Market Forecast 2020-202613. Conclusion

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Biochemistry Analyzer Market 2020: Opportunities in Grooming Regions EMD Millipore Corporation, BD, Bio-Rad Laboratories and Others - Cole of Duty

The impact of the coronavirus on the Growing Demand for XX to Bolster the Growth of the Biochemistry Analyzers Market During the Forecast…

In 2018, the market size of Biochemistry Analyzers Market is million US$ and it will reach million US$ in 2025, growing at a CAGR of from 2018; while in China, the market size is valued at xx million US$ and will increase to xx million US$ in 2025, with a CAGR of xx% during forecast period.

Persistence Market Research recently published a market study that sheds light on the growth prospects of the global Biochemistry Analyzers market during the forecast period (20XX-20XX). In addition, the report also includes a detailed analysis of the impact of the novel COVID-19 pandemic on the future prospects of the Biochemistry Analyzers market. The report provides a thorough evaluation of the latest trends, market drivers, opportunities, and challenges within the global Biochemistry Analyzers market to assist our clients arrive at beneficial business decisions.

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This study presents the Biochemistry Analyzers Market production, revenue, market share and growth rate for each key company, and also covers the breakdown data (production, consumption, revenue and market share) by regions, type and applications. Biochemistry Analyzers history breakdown data from 2014 to 2018, and forecast to 2025.

For top companies in United States, European Union and China, this report investigates and analyzes the production, value, price, market share and growth rate for the top manufacturers, key data from 2014 to 2018.

In global Biochemistry Analyzers market, the following companies are covered:

Company Profiles

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The content of the study subjects, includes a total of 15 chapters:

Chapter 1, to describe Biochemistry Analyzers product scope, market overview, market opportunities, market driving force and market risks.

Chapter 2, to profile the top manufacturers of Biochemistry Analyzers, with price, sales, revenue and global market share of Biochemistry Analyzers in 2017 and 2018.

Chapter 3, the Biochemistry Analyzers competitive situation, sales, revenue and global market share of top manufacturers are analyzed emphatically by landscape contrast.

Chapter 4, the Biochemistry Analyzers breakdown data are shown at the regional level, to show the sales, revenue and growth by regions, from 2014 to 2018.

Chapter 5, 6, 7, 8 and 9, to break the sales data at the country level, with sales, revenue and market share for key countries in the world, from 2014 to 2018.

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Chapter 10 and 11, to segment the sales by type and application, with sales market share and growth rate by type, application, from 2014 to 2018.

Chapter 12, Biochemistry Analyzers market forecast, by regions, type and application, with sales and revenue, from 2018 to 2024.

Chapter 13, 14 and 15, to describe Biochemistry Analyzers sales channel, distributors, customers, research findings and conclusion, appendix and data source.

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The impact of the coronavirus on the Growing Demand for XX to Bolster the Growth of the Biochemistry Analyzers Market During the Forecast...

Global Veterinary Biochemistry Analyzers Market Analysis 2015-2019 and Forecast 2020-2026: Size, Share, Growth Rate, Revenue, Applications, Industry…

In Global Veterinary Biochemistry Analyzers Market Research Report, the study analysis was given on a worldwide scale, for instance, present and traditional Veterinary Biochemistry Analyzers growth analysis, competitive analysis, and also the growth prospects of the central regions. The report gives an exhaustive investigation of this market provides an analysis of the industry trends in each of the sub-segments, from sales, revenue and consumption. A quantitative and qualitative analysis of the main players in Global and country level is introduced, from the perspective of sales, revenue and price.

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Snapshot:The global Veterinary Biochemistry Analyzers market size is estimated at xxx million USD with a CAGR xx% from 2015-2019 and is expected to reach xxx Million USD in 2020 with a CAGR xx% from 2020 to 2025. The report begins from overview of Industry Chain structure, and describes industry environment, then analyses market size and forecast of Veterinary Biochemistry Analyzers by product, region and application, in addition, this report introduces market competition situation among the vendors and company profile, besides, market price analysis and value chain features are covered in this report.

Product Type Coverage(Market Size & Forecast, Major Company of Product Type etc.):

AutomaticSemi-automatic

Company Coverage(Company Profile, Sales Revenue, Price, Gross Margin, Main Products etc.):

BPC BioSedDiaSys Diagnostic SystemsDiconexHeskaRandox LaboratoriesIdexx LaboratoriesScil Animal CareWoodley Equipment

Application Coverage(Market Size & Forecast, Different Demand Market by Region, Main Consumer Profile etc.):

Pet HospitalResearch CenterInspection and Quarantine DepartmentsOther

Region Coverage(Regional Production, Demand & Forecast by Countries etc.):

North America (U.S., Canada, Mexico)Europe (Germany, U.K., France, Italy, Russia, Spain etc.)Asia-Pacific (China, India, Japan, Southeast Asia etc.)South America (Brazil, Argentina etc.)Middle East & Africa (Saudi Arabia, South Africa etc.)

At the upcoming section, this report discusses industrial policy, economic environment, in addition cost structures of the industry. And this report encompasses the fundamental dynamics of the market which include drivers, opportunities, and challenges faced by the industry. Additionally, this report showed a keen market study of the main consumers, raw material manufacturers and distributors, etc.

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Major Point of TOC:

Table of Content1 Industry Overview2 Industry Environment (PEST Analysis)3 Veterinary Biochemistry Analyzers Market by Type4 Major Companies List5 Market Competition6 Demand by End Market7 Region Operation8 Marketing & Price9 Research Conclusion

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Global Veterinary Biochemistry Analyzers Market Analysis 2015-2019 and Forecast 2020-2026: Size, Share, Growth Rate, Revenue, Applications, Industry...

Biochemistry Analyzers Market Products Report 2020-2026 by Industry Trends and Competition Analysis, Forecast to 2026 – Cole of Duty

Biochemistry Analyzers:

This report studies the Biochemistry Analyzers Market with many aspects of the industry like the market size, market status, market trends and forecast, the report also provides brief information of the competitors and the specific growth opportunities with key market drivers. Find the complete Biochemistry Analyzers Market analysis segmented by companies, region, type and applications in the report.

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Biochemistry Analyzers Market continues to evolve and expand in terms of the number of companies, products, and applications that illustrates the growth perspectives. The report also covers the list of Product range and Applications with SWOT analysis, CAGR value, further adding the essential business analytics. Biochemistry Analyzers Market research analysis identifies the latest trends and primary factors responsible for market growth enabling the Organizations to flourish with much exposure to the markets.

Market Segment by Regions, regional analysis covers

Research objectives:

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The Biochemistry Analyzers Market research report completely covers the vital statistics of the capacity, production, value, cost/profit, supply/demand import/export, further divided by company and country, and by application/type for best possible updated data representation in the figures, tables, pie chart, and graphs. These data representations provide predictive data regarding the future estimations for convincing market growth. The detailed and comprehensive knowledge about our publishers makes us out of the box in case of market analysis.

Table of Contents: Biochemistry Analyzers Market

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Biochemistry Analyzers Market Products Report 2020-2026 by Industry Trends and Competition Analysis, Forecast to 2026 - Cole of Duty

Itaconic Acid Market Report (2019-2025) | The demand for the Market will drastically increase in the Future – Cole of Duty

Recent report on Itaconic Acid Market Size by Application, By Types, By Regional Outlook Global Industry Analysis, Share, Growth, Opportunity, Latest Trends, and Forecast to 2025.

The new report offers a powerful combination of latest, in-depth research studies on the Itaconic Acid market. The authors of the report are highly experienced analysts and possess deep market knowledge.

Download Sample Copy of the Report to understand the structure of the complete report (Including Full TOC, Table & Figures): http://marketresearchbazaar.com/requestSample/21564

Major Players Analyzed Under This Report are:

Alpha ChemikaChengdu Jinkai Biology EngineeringItaconix CorporationJinan Huaming BiochemistryShandong Zhongshun Science & Technology DevelopmentSpectrum ChemicalZhejiang Guoguang BiochemistryNanjing Huajin BiologicalsQingdao Langyatai GroupQingdao Kehai BiochemistryRonas ChemicalsShandong Kaison Biochemical

Itaconic Acid Players/Suppliers Profiles and Sales Data: Company, Company Basic Information, Manufacturing Base and Competitors, Product Category, Application and Specification with Sales, Revenue, Price and Gross Margin, Main Business/Business Overview.

Table Of Content

Market Overview: Scope & Product Overview, Classification of Itaconic Acid by Product Category (Market Size (Sales), Market Share Comparison by Type (Product Category)), Itaconic Acid Market by Application/End Users (Sales (Volume) and Market Share Comparison by Application), Market by Region (Market Size (Value) Comparison by Region, Status and ProspectItaconic Acid Market by Manufacturing Cost Analysis:Key Raw Materials Analysis, Price Trend of Key Raw Materials, Key Suppliers of Raw Materials, Market Concentration Rate of Raw Materials, Proportion of Manufacturing Cost Structure (Raw Materials, Labor Cost), Manufacturing Process Analysis

Key Benefits for Stakeholders

The study provides an in-depth analysis of the Itaconic Acid market size along with the current trends and future estimations to elucidate the imminent investment pockets.Information about key drivers, restraints, and opportunities and their impact analysis on the market size is provided.Porters five forces analysis illustrates the potency of buyers and suppliers operating in the portable gaming industry.The quantitative analysis of the Itaconic Acid industry from 2020 to 2026 is provided to determine the Itaconic Acid market potential.

Itaconic Acid Market is estimated to reach xxx million USD in 2020 and projected to grow at the CAGR of xx% during 2020-2026

The research report is broken down into chapters, which are introduced by the executive summary. Its the introductory part of the chapter, which includes details about global market figures, both historical and estimates. The executive summary also provides a brief about the segments and the reasons for the progress or decline during the forecast period. The insightful research report on the Itaconic Acid market includes Porters five forces analysis and SWOT analysis to understand the factors impacting consumer and supplier behavior.

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Market Segment Analysis

The research report includes specific segments by Type and by Application. Each type provides information about the production during the forecast period of 2015 to 2026. Application segment also provides consumption during the forecast period of 2015 to 2026. Understanding the segments helps in identifying the importance of different factors that aid the market growth.

Segment by Type SynthesisFermentation

Segment by Application PlasticizerLubricating Oil AdditiveOthers

Itaconic Acid Market: Competitive Landscape

This section of the report identifies various key manufacturers of the market. It helps the reader understand the strategies and collaborations that players are focusing on combat competition in the market. The comprehensive report provides a significant microscopic look at the market. The reader can identify the footprints of the manufacturers by knowing about the global revenue of manufacturers, the global price of manufacturers, and production by manufacturers during the forecast period of 2015 to 2019.

Itaconic Acid Market: Regional Analysis

The report offers in-depth assessment of the growth and other aspects of the Itaconic Acid market in important regions, including the U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, Taiwan, Southeast Asia, Mexico, and Brazil, etc. Key regions covered in the report are North America, Europe, Asia-Pacific and Latin America.

The report has been curated after observing and studying various factors that determine regional growth such as economic, environmental, social, technological, and political status of the particular region. Analysts have studied the data of revenue, production, and manufacturers of each region. This section analyses region-wise revenue and volume for the forecast period of 2015 to 2025. These analyses will help the reader to understand the potential worth of investment in a particular region.

Key Strategic Developments:The study also includes the key strategic developments of the Itaconic Acidmarket, comprising R&D, new product launch, M&A, agreements, collaborations, partnerships, joint ventures, and regional growth of the leading competitors operating in the market on a global and regional scale.

Key Market Features:The report evaluated key market features, including revenue, price, capacity, capacity utilization rate, gross, production, production rate, consumption, market share, CAGR, and gross margin.Analytical Tools: The Itaconic Acid Market report includes the precisely studied and weighed data of the key industry players and their scope in the Itaconic Acid market by means of several analytical tools

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Itaconic Acid Market Report (2019-2025) | The demand for the Market will drastically increase in the Future - Cole of Duty

Metal in Urine Provides Potential Noninvasive Test for Pancreatic Cancer – State of the Planet

New research has revealed that the signature of metal ions present in urine samples is an accurate indicator of pancreatic ductal adenocarcinoma (PDAC), one of the deadliest types of cancer.

The discovery could signal the possibility of a new and completely noninvasive test for pancreatic cancer, of which PDAC is by far the most common form. Although it accounts for only 2.5 percent of new cancer cases, pancreatic cancer leads to 6 percent of cancer deaths worldwide each year, because the mortality rate is so high, at around 85 percent. No tests for early detection are currently available, and as symptoms are usually nonspecific, PDAC is normally diagnosed at a late stage when it is already locally advanced or has spread to other parts of the body. Any improvement in tests for early detection would therefore represent a breakthrough.

The study, published in the journal Metallomics, took as its starting point the fact that cancer leads to changes in biochemical reactions within the body. These changes, if measurable, can be powerful tools for detection. The research team discovered that PDAC patients had significantly lower levels of urinary calcium and magnesium, and increased levels of copper and zinc, when compared to healthy controls. A combined analysis of these essential metals was shown to be an accurate indicator of biochemical changes related to PDAC. The team also found that the urine of PDAC patients has higher levels of a particular isotope of zinc compared to healthy controls.

Lead author Kathrin Schilling, who did the work while at the University of Oxford, said, As urine samples can be taken time and time again in a noninvasive way, we can start to talk about an effective method to screen and monitor high-risk groups for pancreatic cancer. Our results show that developing new science crossing interdisciplinary boundaries can address really important needs in medicine. Schilling is now based at Columbia Universitys Lamont-Doherty Earth Observatory.

The studys senior author, Tatjana Crnogorac-Jurcevic from Queen Mary University London, said, We are very excited about our findings, and hope that we will be able to continue this work and further validate obtained results.

The researchers say the next step will be to study the levels of metals in a larger number of urine samples as well as in prediagnostic urine samples, to see if changes in their levels can be detected before the symptoms of cancer appear. If the results are still promising, the metal biomarkers will then be tested in a real clinical scenario. Researchers at Barts Cancer Centre, who coauthored the new study, have already embarked on a study of protein biomarkers in the urine of PDAC patients.

Other research groups involved were the Lamont-Doherty lab of Alex Halliday, director of Columbias Earth Institute; and the Department of Pediatrics and Pediatric Infectious Diseases at Russias Sechenov First Moscow State Medical University.

Adapted from a press release by the University of Oxford.

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Metal in Urine Provides Potential Noninvasive Test for Pancreatic Cancer - State of the Planet

Scientists shed light on action of key tuberculosis drug – University of Birmingham

A new study led by scientists at the University of Birmingham has shed fresh light on how a key front-line drug kills the tuberculosis bacterium.

The research paves the way for development of new antibiotic drugs targeted at emerging strains of TB.

Tuberculosis (TB) remains a global health challenge, responsible for around 1.5 million deaths each year, with particularly high incidences in India, China and Indonesia. There is an urgency to better understand how effective drugs work against the disease because of the emergence and spread of new strains including multi-drug resistant and extensively resistant strains.

Called ethambutol, the drug the scientists were studying has been a mainstay in the fight against TB since its discovery in 1961. Despite this, the drugs mode of action the way it kills the bacterium has not been fully confirmed by scientists.

In this study, published in the journal Science, the research team succeeded in confirming that particular groups of proteins within the TB bacterium, called Emb proteins, are targeted by ethambutol. Although the importance of these proteins had previously been recognised, a lack of structural and biochemical data had prevented scientists from confirming precisely how the drug targets them.

The study, carried out in collaboration with scientists from ShanghaiTech, in China, and the University of Queensland in Australia, succeeds in overcoming this barrier.

Researchers used cryogenic electron microscopy and x-ray imaging to study the structures of a series of Emb proteins for the first time. They were able to show how different Emb proteins were responsible for specific physiological functions producing crucial components of the TB cell wall.

They were also able to show how ethambutol binds to and inactivates these Emb proteins.

Professor Gurdyal S. Besra, in the Institute of Microbiology and Infection and the School of Biosciences at the University of Birmingham, is a lead author of the paper. He says: This exciting breakthrough with our colleagues from China and Australia will inform a range of medical researchers from a wide range of disciplines; from structural biologists, biochemists, chemists, and microbiologists, and most importantly, scientists in the pharmaceutical industry aiming to develop new TB antibiotics targeting this unique set of proteins for the first time.

The research was funded in the UK by the Medical Research Council.

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Global Automatic Biochemistry Analyzers Market anticipated grow at a CAGR of xx% over the forecast period 2020-2025 :Roche, Horiba Medical, Danaher,…

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Dihydropyridine Market 2020 | Know the Latest COVID19 Impact Analysis And Strategies of Key Players: Shenzhen Simeiquan Biotechnology Co.Ltd, Boc…

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Carole Carson: Adventures in Aging Seven myths about getting older – The Union of Grass Valley

How many of these myths do you accept as reality?

Myth 1: When it comes down to it, aging is just another disease, asserts professor David Sinclair, PhD, a Harvard professor.

He is convinced that aging, like obesity, is a pathological condition that scientists will eradicate.

Reality: If aging is a disease, it must be highly contagious because all my patients get it, says Dr. Todd Bouchier, a Grass Valley physician. And everyone over the age of 65 has an advanced case.

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Humor aside, Dr. Bouchier continues, aging is not a disease. Over time, mountains crumble, barns collapse, and cells degenerate. Aging is a fact of nature. Scientists get excited about the possibility of escaping the preprogrammed aspects of cellular aging. No doubt, well make gains and eventually live longer but wont eliminate aging. Making the final years as meaningful as possible is the goal.

Myth 2: All seniors are alike and are best described as sexless, toothless, prune juice-drinking dribblers who watch daytime television and shuffle like Tim Conway.

Reality: People live more diverse lives over time. People in their 20s are more alike than folks in their 80s. We even age differently. Four distinct ageotypes metabolic, immune, hepatic (liver), and nephrotic (kidney) determine how and where in the body biologic aging occurs.

As for sex, studies show that seniors enjoy sex and variations of sexual activity beyond middle age. Moreover, the need for intimacy touching, hugging, or holding hands is timeless.

Myth 3: Old timers are a drain on society, sucking up resources the younger folks need. The fewer seniors in a community, the healthier it is. The coronavirus can thin the herd.

Reality: Over 1,200 nonprofit and 501(c) organizations operate in Nevada County, enriching our community in immeasurable ways. Funding and volunteer support (estimated at 10,000 hours annually) rely heavily on seniors for these civic and social activities.

Plus, increasing numbers of seniors work. And even those who arent on a payroll still work as grandparents and caregivers.

As for welfare, older people have emerged as the wealthiest segment of our population.

Myth 4: Seniors dont need or buy much, hence, commercials focus on young people, except for depressing pharmaceutical ads.

Reality: The 65-and-older population is the mother of all untapped markets, according to Barrons. In 2015, the spending of Americans ages 50 and up accounted for nearly $8 trillion worth of dollars spent. By 2030, the 55-and-older population will have accounted for half of all domestic consumer spending growth.

And even when household income for older people is at or below the median, they have as much or more disposable income as young people with the same income.

Myth 5: You cant teach an old dog new tricks. Technology is wasted on seniors. Humans are born with a finite number of brain cells that die off with aging.

Reality: Learning patterns may change and the speed of learning may diminish, but the basic capacity to learn is retained. As for technology, in 2000, 14% of those aged 65 and older were internet users; now 73% are.

Moreover, through the process of neurogenesis, brain cells adapt and reconnect even regrow and replenish. Thanks to brain plasticity, we old dogs can teach young dogs some new tricks!

Myth 6: To be old is to be irritable and grumpy. Depression is inevitable given the declining trajectory of deteriorating mental and physical health.

Reality: Depression is not a normal part of aging but rather an illness requiring treatment. The course of depression in the elderly is identical to that of younger persons, and the response to treatment appears as positive as that of people in other life stages.

Myth 7: Senior moments signal the onset of dementia, a disease no one escapes if they live long enough. The lights are still on, but the voltage is low.

Reality: Forgetfulness occurs at all ages, but were more inclined to notice as we age. The good news is that the rate of dementia is declining and occurring at older and older ages. Only 5% of people over age 65 have dementia. In addition, some memory loss is caused by medications and medical conditions unrelated to aging.

The best news is that aging and dementia are not inextricably linked. Evidence is growing that regular exercise, healthful eating, and mentally challenging activities can preserve cognitive functions independent of age.

Accepting these myths holds us back. It cuts us off from opportunities that are jumping up and down in front of us seeking to get our attention. Knowing the truth, on the other hand, sets us free to explore our options while we celebrate the simple joy of being alive.

Next Month: Your body over time

Carole Carson, Nevada City, is an author, former AARP website contributor, and leader of the 1994 Nevada County Meltdown. Contact: carolecarson41@gmail.com.

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Carole Carson: Adventures in Aging Seven myths about getting older - The Union of Grass Valley

When will we know if COVID-19 antibodies prevent reinfection? – ABC News

Antibody tests, which reveal whether someone has been infected with the novel coronavirus, have been touted as key to reopening the economy and restoring a sense of stability to quotidian life. The hope is that people who've been infected by and develop antibodies may be able to ward off future reinfections, confidently returning to everyday life.

But for now, it's just that: a hope. Medical experts have said it's premature to rely on antibody testing as a singular solution to reopening the economy.

One crucial step will be determining whether antibodies indeed confer immunity and protect an individual from further reinfection, which experts said could take years to determine. Experts studying this new virus still don't know if these antibodies indicate protection -- and, if so, for how long, to what extent?

"This outbreak is moving much more rapidly than previous coronavirus outbreaks have -- it's more widespread, with a greater number of patients," Dr. Aneesh Mehta told ABC News. His team at the Division of Infectious Diseases at Emory University School of Medicine has now helped launch a COVID-19 antibody testing initiative.

Mirimus, Inc. lab scientists work to validate rapid IgM/IgG antibody tests of COVID-19 samples from recovered patients on April 10, 2020, in the Brooklyn, New York.

Results so far have been telling, but time's required to gauge the strength and longevity of the average person's antibody response.

"We believe that the antibodies that we're detecting do confer some level of protection, but we want to know how much and how long that protection lasts," Mehta added.

Studying previously documented immune responses that included antibody production may help researchers better understand the properties of antibodies produced against COVID-19.

But not all antibodies are created equal -- tremendous variance is seen in immune system responses to different viruses. Some antibodies confer early and long-term immunity, while others take longer to develop and are short-lived, providing a limited period of protection. It's now known that antibodies produced in patients who contracted SARS, which emerged less than two decades ago and belongs to the same coronavirus family as COVID-19, confer protective immunity for several years.

Medical professionals are hopeful antibodies produced in response to COVID-19 offer similar protection. Preliminary studies on monkeys suggest COVID-19 antibodies provide partial, short-term protective immunity to reinfection, but, as Harvard epidemiologist Marc Lipsitch recently wrote for The New York Times, these early results are just "educated guesses."

Antibody tests primarily are used to develop more robust surveillance systems to estimate the scope of disease spread, and while useful for estimating infection and mortality rates, the tests hopefully soon can be used to identify which antibodies provide recovered COVID-19 patients with immunity, scientists said. This approach was used in identifying protective antibodies for MERS and SARS.

A driver receives a COVID-19 test kit at a coronavirus mobile testing site at Lincoln Park in Los Angeles, Calif., on April 10, 2020 as COVID-19 antibody testing begins at locations across Los Angeles County.

As government officials spearhead mass antibody testing initiatives, science and medicine are rushing to catch up.

"We're kind of racing the clock," Dr. David Koch, director of clinical chemistry, toxicology and point of care testing at Grady Memorial Hospital, told ABC News.

U.S. experts are looking to data from other countries that are ahead of the curve, such as Italy and South Korea, for glimmers of insight on COVID-19 antibodies.

And, as Koch noted, with some viruses reinfection is always possible.

"Other viruses and infections that produce antibodies, the person is liable to get the same illness again later, like the common cold," Koch added.

Select preliminary studies from other countries suggest COVID-19 reinfection is possible, but more research is required to determine whether a patient's second positive test is a new infection or remnants of the first.

And if the virus mutates, would those who endured an earlier iteration still be protected?

"It's going to take people who have known antibodies to COVID-19 to be re-exposed and find out if their protective antibodies come back to elevated levels and protect them -- or not," Dr. Carmen Wiley, president of the American Association for Clinical Chemistry, told ABC News.

Mirimus, Inc. lab scientists work to validate rapid IgM/IgG antibody tests of COVID-19 samples from recovered patients, April 10, 2020 in New York.

"It'd be nice to know all these answers tomorrow," Koch added. "But nobody's a magician, nobody's a savant about these things. Even Dr. Fauci. People as experienced as he is are still rather befuddled. You go back to late January, February, even the experts were making misstatements."

The quality of antibody tests for COVID-19 also has come into question. Although they've skyrocketed in number, only four have received an Emergency Use Authorization from the Food and Drug Administration. Others have been approved for manufacturing in case they're proven effective.

Experts told ABC News there's concern tests of dubious quality could make it to market without being properly vetted.

"Each antibody test tells a different story," Koch said.

At Beaumont Health, researchers have said they want to test all 38,000 employees, whose jobs place them at a higher risk of COVID-19 infection, for related antibodies. The study's aim is to monitor the rate of infections, as well as the longevity and long-term effectiveness of the antibodies produced.

This week in California, USC and the LA County Department of Public Health released preliminary results from a collaborative study that showed virus spread among the local population may be more widespread than previously thought. Although immediately worrisome, perhaps it's good news for the at-large antibody quotient.

But the World Health Organization has cautioned against relying too heavily on a single study. So much more data remains to be collected.

"I wish I could tell you how long it would take to produce that longevity," Mehta said. "Not only do we feel this pressure externally -- we feel this pressure because we want to help people. We have to make the best decisions we can in the environment we're in."

Mehta excused himself to check on a recovering patient, adding: "We're always improving."

Tune into ABC at 1 p.m. ET and ABC News Live at 4 p.m. ET every weekday for special coverage of the novel coronavirus with the full ABC News team, including the latest news, context and analysis.

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Queen Elizabeth’s Healthy Diet May Be The Secret To Her Longevity – Yahoo Lifestyle

From Delish

Queen Elizabeth II isnt just the United Kingdoms longest reigning monarch; shes the oldest head of state in the world. And at 94 years old, she surpassed the average life expectancy for women in the UK by a decade.

While her status undoubtedly gives her unparalleled access to the best doctors, chefs, and ingredients, shes also known to have a surprisingly simple approach to food and nutrition. Heres what you can learn from Her Majestys healthy eating habits.

Former palace chef Darren McGrady told RecipesPlus that, unlike Prince Phillip who lives to eat, Queen Elizabeth eats to live and sticks to small portion sizes, preferring four light meals instead of three larger ones.

If youve ever tried to lose weight, you know how important portion control is for your waistline: University of Cambridge researchers estimate that smaller packages and portion sizes could help us cut our daily food consumption by about 25%, and according to a report from the McKinsey Global Institute, reducing portion size is the most effective way to fight obesity. (Need help in the portion department? Check out these easy portion control tips.)

For Queen Elizabeth, that means eating every slice of chocolate cake. Shell take a small slice every day until eventually there is only one tiny piece, but you have to send that up, she wants to finish the whole of that cake, McGrady said. As for other types of cake? The staff can eat the leftovers.

Research shows that treating yourself is an important part of a healthy, long-lasting diet. One Israeli study found that people who start their day with chocolate, cookies, or ice cream may be better able to manage cravings long-term. Cravings increase on a low-carbohydrate diet, so its better to incorporate them in a healthy way, says Daniela Jakubowicz, M.D., of the Diabetes Unit at Wolfson Medical Center at Tel Aviv University, and author of the study. Dr. Jakubowicz suggests treating yourself in the morning for the best results; her other research shows that a hearty breakfast is more beneficial to weight loss than a heavy dinner.

Story continues

The Queen likes her chocolate 60% or higher, reports Business Insider. It has to be the dark chocolate, the darker the better, McGrady confirmed. She wasnt keen on milk chocolate or white chocolate. Thats a good choice considering dark chocolate is rich in flavonoids, which may protect against heart disease and stroke, according to a Tufts University review.

The Queen is all about eating strawberries in the summer, but McGrady says she wont touch them in the winter. She absolutely does eat seasonal, he told RecipesPlus.

While eating out-of-season strawberries might not seem like a big deal, there are real benefits to following Mother Natures lead when it comes to produce. Out-of-season food travels thousands of miles before it hits store shelves, which may compromise its nutritional value. Vitamin C is particularly unstable: Research from Bangladesh found that tomatoes lose more than half their vitamin C over the course of eight days.

If you cant grow fruits and vegetables from your own garden like Queen Elizabeth does, we suggest hitting up your local farmers marketyou wont need a royal budget, either.

A heart healthy staple of the Mediterranean diet, the Queen often has smoked salmon sandwiches with her afternoon tea and a grilled fish for lunch or dinner. Do the same to keep your mind and body healthy: Fatty fish such as salmon, sardines, and herring have the omega-3s EPA and DHA, which can help you lower risk of heart disease, Amy Gorin, M.S., R.D.N., recently told Prevention. Fatty fish is also a staple of the MIND diet, which combines the best of the Mediterranean and DASH diets for research-backed dementia protection.

This wouldnt be a story about the royals without a reference to tea, would it? The Queens favorite, Earl Grey, may lower cholesterol, thanks to the flavonoids in bergamot. And thats not even mentioning the benefits of black tea in general: the tannic tea may lower your blood pressure, reduce your risk of ovarian cancer, and promote weight loss. No fine china necessary.

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