Wissot: Cabin fever has replaced spring fever – Vail Daily News

Before they moved to Los Angeles, the Brooklyn Dodgers were baseballs version of the poetic line: hope springs eternal in the human breast. Dem Bums, as they were affectionately referred to by their loyal fans, played the rival New York Yankees five times in the World Series between 1941 and 1953. They lost each time. They finally beat the Yankees in 1955 and then played them the following year, promptly resuming their losing ways.

With each disappointing end to the season, their fans would utter the plaintive plea, wait till next year.

This spring is our Brooklyn Dodgers moment. We will have to wait until next year to experience spring fever. We have lost too many lives to generate the pent-up excitement which normally accompanies the greening grass, blooming flowers, and warming temperatures. Cabin fever has replaced it.

Social distancing and sheltering in place are playing havoc with the rituals of the season. Some of the casualties are gathering around the table with family and friends for Easter brunches and Passover seders; proms and graduations; Cinco de Mayo celebrations; Mothers Day parties; June weddings with more than the bride and groom in attendance.

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Flowers are not all that come alive in spring. Hormones ignite and the chemistry fueling human reproduction gets a rocket boost. But romance is severely impaired when two people wearing masks and standing 6 feet apart lock eyes for the first time across a crowded room. Passion is best expressed when touching is permitted. Under the current distancing guidelines, one night stands are really challenging.

The Colombian writer Gabriel Garcia Marquez believed that disease neednt stand in the way of romance when he wrote Love in a Time of Cholera. Following his lead, Im sure Netflix will soon be streaming Sex, Lies and Coronavirus Videotapes.

Married couples and partners cohabitating dont have to follow social distancing practices unless one partner shows symptoms. Being in confined quarters for weeks and months will certainly test the strength and resiliency of relationships. Growing closer together or moving further apart are at the polar end of possibilities.

It will be interesting to track once this pandemic is tamed whether there has been an increase in the number of births and divorces. Corona babies and corona splits could prove to be a lasting reminder of what happens when an entire country is on lockdown.

Im surprised at how little I miss televised sports. When the NBA suspended play on March 11, it took a few days to adjust. Id reflexively reach for the remote to watch a game before realizing there werent any games to televise. After a week, I stopped reaching. Out of sight. Out of mind.

But there are four sporting events which take place at the same time each year in April and May that I will regret not seeing. They always served as reliable harbingers of spring a first respite from wintry melancholy. The Masters golf tournament is held the first full week in April and the Boston Marathon on Patriots Day, the third Monday of the month. The running of the Kentucky Derby is the first Saturday in May; the Indianapolis 500 on Memorial Day weekend. They are four of the best-known traditions in American sport, sequentially tracing the evolution of human movement from walking to running to riding to driving.

Like you, I feel this shelter in place way of life gets old fast. But for as long as the siege lasts, I am prepared to make the best of my quarantined existence.

This is the only time in my life where what I do for my own well-being serves the public welfare. Its a big responsibility, a heavy moral burden. But one I accept gladly and proudly.

After all, there are worse things than the monotony of cabin fever. Hospitalization immediately comes to mind.

Jay Wissot is a resident of Denver and Vail. Email him at jayhwissot@mac.com.

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Wissot: Cabin fever has replaced spring fever - Vail Daily News

Shirley Chisholm: What ‘Mrs. America’ gets right and wrong – Los Angeles Times

If youve watched any of Mrs. America, the star-studded miniseries about the battle of the Equal Rights Amendment, you may be wondering how accurately it captures this divisive chapter in American political history.

The nine-part drama pits conservative activist Phyllis Schlafly (Cate Blanchett) and her followers against a band of feminist all-stars led by Gloria Steinem (Rose Byrne), Bella Abzug (Margo Martindale) and Betty Friedan (Tracey Ullman), who are prone to spirited internal debates. Creator Dahvi Waller and her team of writers conducted extensive research into Second Wave feminism and the rise of the new right in the 1970s.

Like nearly all works of historical fiction, Mrs. America takes some liberties, particularly when it comes to private conversations behind closed doors, and it offers a necessarily subjective take on highly polarizing figures such as Schlafly. But when it comes to events in the public record, Mrs. America hews close to the facts, often quoting feminist leaders and their critics verbatim.

Overall, they have done a very good job, said historian Marjorie Spruill, author of Divided We Stand: The Battle Over Womens Rights and Family Values That Polarized America.

Episode three explores the thorny intersection of race and gender on both sides of the ERA debate. Rep. Shirley Chisholm (Uzo Aduba), the first black woman elected to Congress, makes a historic run for the presidency in 1972 but faces skepticism from both the womens movement and other black politicians. Meanwhile, Democrats fight over abortion and ERA opponents grapple with racism in their ranks.

Heres a look at fact versus fiction in episode three, Shirley:

Uzo Aduba as Shirley Chisholm in Mrs. America.

(Sabrina Lantos / FX)

Shirley Chisholm was stung by the lack of support she received from the womens movement and black politiciansAs the convention approaches, Chisholm, one of the founders of the National Womens Political Caucus, faces pressure to drop out from her supposed allies including Rep. Ron Dellums (Norm Lewis), cofounder of the Congressional Black Caucus, who tells Chisholm they question whether she is the candidate for blacks, or just for women. She also struggles with wavering support from her peers in the NWPC, Abzug and Steinem.

As a trailblazing black woman in politics, Chisholm was used to having her loyalty questioned. When she declared her candidacy at an event in Brooklyn in January 1972, she said, I am not the candidate of black America, although I am black and proud. I am not the candidate of the womens movement in this country, although I am a woman and I am equally proud of that. During a campaign stop in Los Angeles, Chisholm confronted doubts about her candidacy in the black community Not many black people can really believe that a black person, who also happens to be a woman, can become president of this country and also fielded questions about why she chose not to wear her hair in a natural look.

Indeed, as Barbara Winslow writes in her book Shirley Chisholm: Catalyst for Change, Chisholm was viewed with skepticism and in some cases anger by the leading black male politicians of the time because they believed she would be viewed as the womens candidate. And she was heartbroken when Dellums, her longtime supporter, bailed on her at the last minute to endorse McGovern as depicted in Mrs. America.

Likewise, Chisholm received only lukewarm support from leading feminists, according to Winslow. Abzug never formally endorsed her, while Steinems support was qualified by the fact that she named McGovern the best of the male candidates. Chisholm actually confronted Steinem on a Chicago TV show about her semi-endorsement. Years later, Steinem expressed regret over the issue.

Another Mrs. America detail that stands up to scrutiny? According to Winslows book, Chisholm received multiple death threats and was given Secret Service protection. The FBI also investigated a racist smear campaign against her involving forged press releases written on stolen Hubert Humphrey campaign stationery.

Rose Byrne plays Gloria Steinem in Mrs. America.

(Sabrina Lantos / FX)

There was a fight over abortion at the 1972 Democratic Convention. And, yes, Shirley MacLaine helped keep the issue out of the party platformAt the 1972 Democratic Convention in Miami, the NWPC emerged as a political force. Women made up 38% of the delegates, up from 13% in 1968, and some wanted to leverage their newfound clout to get the party to support reproductive choice at a time when abortion was still illegal in much of the country. (The Supreme Court would hand down its decision in Roe v. Wade about six months later.)

In Shirley, we see Steinem and Abzug meeting with George McGoverns campaign director Gary Hart (John Palladino) and McGovern delegate Shirley MacLaine (Vanessa Smythe). Using an arcane mechanism of the convention rules, Steinem pledges 100 female delegates from California to McGovern in exchange for a floor vote on a reproductive rights plank. But when it looks like the measure might pass, Hart panics and pulls a delegate switcheroo, resulting in a bitter loss for abortion-rights proponents particularly Steinem.

Which is basically what happened. In her colorful dispatch from the convention for Esquire Magazine, Nora Ephron wrote, The fight over the abortion plank which was referred to as the human-reproduction plank because it never once mentioned the word abortion produced the most emotional floor fight of the convention. She describes a tearful Steinem calling Hart a liar and a bastard, and Abzug screaming at Shirley MacLaine. For her part, the actress defended her role in the incident in a piece for the New York Times, explaining her pragmatic opposition to the plank despite her personal support for abortion rights. It seemed to me a strong abortion plank would hurt not only George McGovern but the issue itself, she wrote at the time.

The shows portrayal of Steinem as idealistic and Abzug more grounded is fair, Spruill said. Steinem hates political compromises. And Abzug is also concerned about economic and racial justice as well as gender. But she also is a politician who deals in the world of whats possible and understands that better. She was concerned that they get McGovern elected first.Phyllis Schlafly probably did turn a blind eye to racists in her movementIn the same episode, Schlafly acolyte Alice (Sarah Paulson) confronts Mary Frances (Melinda Page Hamilton), a Stop ERA member from Louisiana, about her racist language. Schlafly intervenes in the dispute and taps Mary Frances to lead her state organization but reminds members to stick to approved talking points. It serves our cause better to all use identical language, she says. In other words: Its fine if youre racist, just dont advertise it because it makes us look bad.

While the specific scenario appears to have been manufactured by the writers of Mrs. America, the dynamic it portrays is accurate, according to Spruill, who interviewed Schlafly on multiple occasions.

She told me, I am an equal-opportunity opponent of the ERA, and any group that is opposed to it, whatever their reasons, are welcome to work with us, Spruill said. In her research, Spruill also found that a significant number of prominent Stop ERA members were affiliated with far-right organizations such as the John Birch Society and segregationist groups including Women for Constitutional Government, which was founded in opposition to the integration of Ole Miss.

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Shirley Chisholm: What 'Mrs. America' gets right and wrong - Los Angeles Times

Cork clinic hoping to resume some fertility treatments in May – Echo Live

The Sims Clinic, which operates a facility at City Gate in Mahon, says it is hoping to resume some of its fertility treatments next month, but it awaits government guidance on the situation.

The clinic, like others across Europe, had deferred fertility treatments following recent recommendations from the European Society of Human Reproduction and Embryology (ESHRE) that assisted reproduction treatments such as IVF should temporarily not be carried out in the wake of the COVID-19 pandemic.

ESHRE has now reviewed these recommendations and says that once the risk of COVID-19 infection is decreasing, treatments can be resumed in line with local regulations.

It has urged however that "vigilance and measured steps must be taken for safe practice and to minimise the risks related to SARS-CoV-2/COVID-19-positive patients or staff during treatment."

The Sims Clinic said it would look to resume some of its treatments in May, adding "however, we still await government guidance on the situation."

It said the resumption of services would be on a phased basis.

The safety of patients and staff is of paramount importance to us and we are making all preparations necessary. We have sourced PPE equipment and are ensuring our clinics are prepared for social distancing, the Sims Clinic said.

The clinic said that this would take some time and that staff will start to contact patients regarding their treatment next week.

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Cork clinic hoping to resume some fertility treatments in May - Echo Live

World Malaria Day a Good Time to Remember COVID-19 Isn’t the Only Crisis – The Wire

An Anopheles stephensi mosquito obtains a blood meal from a human host through its pointed proboscis in this undated handout photo obtained by Reuters, November 2015. Photo: Reuters/Jim Gathany/CDC.

The latest World Malaria Report released in December 2019 said there were 228 million malaria cases in 2018, down 3 million from 2017. In 2018, an estimated 405,000 people died of malaria, down about 2.6% from 2017. While African nations accounted for most cases as well as deaths, South Asia including India has one of the worlds highest malaria burdens.

According to the WHO, 19 countries in sub-Saharan Africa plus India bore almost 85% of the global malaria burden in 2019. Of them, only India reported any progress in reducing the number of malaria cases. (Interestingly, Algeria was declared malaria-free last year.)

According to the WHO, Malaria is a life-threatening disease caused by parasites that are transmitted to people through the bites of infected female Anopheles mosquitoes. Importantly, it is preventable as well as curable.

There are thousands of mosquito species in the world that are vectors for diseases like dengue, filariasis, chikungunya, yellow fever, elephantiasis, Japanese encephalitis and brain fever.

In 1897, a British medical doctor named Ronald Ross discovered that the female Anopheles mosquitoes are responsible for spreading malaria. Ross was born in the Almora district of Indias Uttarakhand. He studied in London and came back to India to work on malaria from 1882 to 1889. He found the link between mosquitoes and malaria transmission 15 years into his studies, and was awarded the medicine Nobel Prize in 1902 for describing the complete life cycle of the malarial parasite.

World Mosquito Day is observed every year on August 20 in recognition of his work, and even then the eradication of malaria is a major part of its awareness campaign.

In humans, malaria is caused by five species of parasites of the genus Plasmodium. Of these, P. falciparum accounts for the majority of malaria cases and deaths because of the severity of the infections it can cause (although infections of P. vivax have also been known to be dangerous). When a female Anopheles mosquito carrying a Plasmodium parasite bites a human, the parasite is transmitted through the skin. First, it invades first the liver through asexual reproduction and then targets the red blood cells. As a result, the human develops symptoms like fever with chills and anaemia, etc. If left untreated, malaria can kill.

At present, a major barrier to eradicating malaria is that malarial parasites have developed resistance against commonly used drugs to treat them, including chloroquine, sulfadoxine/pyrimethamine and even to the newer artesunate-based combination therapies. In the absence of an effective vaccine, its crucial that we find a way to restore these drugs potency against the parasite or develop new drugs that can be effective.

The ongoing novel coronavirus pandemic hasnt made matters easier, even if the world has developed (even temporarily) a heightened awareness of the effects of infectious diseases.

Since the virus is new, were still discovering more about it even as were working towards a vaccine. So in the meantime, researchers have been repurposing vaccines and other fever-curing drugs already approved by various regulatory bodies to resist COVID-19. This is how hydroxychloroquine, a very important antimalarial drug, hit the limelight and which Indias apex medical research body has recommended to the countrys healthcare workers as a prophylaxis, even if there is no evidence that it can effectively prevent COVID-19.

On the flip side, however, hydroxychloroquine tablets have become harder to find and use in places where chloroquine still remains effective against malarial parasites.

Additionally, and even though the current pandemic situation is serious, controlling malaria is also very important but has often been sidelined in the headlong rush to avoid the novel coronavirus. Both COVID-19 and malaria patients have fever, but more people with fever get tested for COVID-19 first before malaria. As a result, malaria diagnosis and treatment may get delayed.

There is no vaccine to prevent or cure malaria. One, designated RTS,S/AS01 and named Mosquirix, is currently undergoing clinical trials, after having displayed partial protection against malaria in young children.

Even though its easier said than done in the throes of a pandemic, its important that we keep up precaution, prevention, early detection and effective treatment, together with mosquito control efforts, to vanquish malaria.

Brief note on prevention

To lower your chances of getting malaria, considering the following steps:

G. Lakshmi is a life-sciences research scholar. Shilpi Garg is affiliated with BITS Pilani.

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World Malaria Day a Good Time to Remember COVID-19 Isn't the Only Crisis - The Wire

When a virus jumps: of man, microbes and pandemics – Livemint

Even as lockdowns around the world continue, including in India, the number of novel coronavirus cases has crossed 2.7 million. The virus, which started spreading from Wuhan, China, in December, has so far claimed more than 190,000 lives globally. In India, the number of covid-19 cases has crossed 23,000, with 720-plus deaths so far.

But this is not the only major outbreak the world is dealing with right now.

February saw parts of Africa reeling under an Ebola outbreak, while Saudi Arabia had a resurgence of cases of MERS, or the Middle East respiratory syndrome. China had a few cases of the rare but deadly hantavirus disease in March.

The common thread? They are all zoonosesdiseases that crossed the species barrier from animal hosts before infecting human beings.

According to the World Health Organization (WHO), the world sees an estimated one billion cases of illness and millions of deaths every year from zoonotic diseases. Around 60% of the emerging infectious diseases, or EIDs, are zoonotic. A February 2008 paper, published in the scientific journal Nature, analysed a database of 335 EID events" between 1940-2004. It concluded EID events had risen significantly over time and are dominated by zoonoses, with the majority originating in wildlife.

But why is this happening? Why are viruses making the jump from animals to humans more frequently?

Each time you have a disease, it is a sign that deep down the relationship between man and microbe has changed in some fundamental way. Something has changed," says Thomas Abraham, a former editor at the South China Morning Post and adjunct associate professor at The University of Hong Kongs Journalism and Media Studies Centre. Abraham also authored the 2004 book Twenty-first Century Plague: The Story Of SARS.

Speaking from Bengaluru, he explains that human populations have grown at an unprecedented rate since the 1900s. We have expanded sixfold at least," he says. People have ventured into areas they had never lived in. Forests are being cut, lakes are being drained, the environment is changing, and we are also coming into contact with new forms of animal life. As we come in closer contact, the pathogens that these animals have, which are probably harmless to them, get an opportunity to pass on to man," he adds.

Another reason is our ability to detect and classify these diseases better. When you identify the causes, what you thought was one big disease is actually probably 10 different diseases," he adds.

MANAGING THE ECOSYSTEM

Before covid-19, the most recent flare-up of a zoonotic disease in India was the Nipah virus outbreak in Kerala two years ago. In 1957, the western and central districts of Karnataka suffered the Kyasanur Forest disease, caused by a virus of the same name, for the first time. Also known as monkey fever, the virus original carriers are hard ticks that infect other animals as well as humans. Human cases become more frequent when a person comes in contact with infected animals that might also carry the ticks as parasites.

The ticks existed in deep forest areas where humans didnt go. Thats why the disease didnt get transmitted. I correlate this with the covid-19 virus. It supposedly originated from bats because humans have come in much closer contact with them," says Yogesh Gokhale, area convenor, Centre for Forest Management & Governance at The Energy and Resources Institute, a Delhi-based think tank.

Seasonality plays a big role in the spread of this disease, with more cases reported in dry periods. Worryingly, climate change effects have a constant influence on man-animal interface and zoonotic diseases. While some disease vectors are sensitive to temperature changes, extreme changes in temperature also impact transmission patterns. So rising global temperatures become a key factor in the prevalence and re-emergence of zoonotic diseases.

Across the world, warmer temperatures and the combination of warmer temperatures and high humidity widens the transmission window for vector-borne diseases. This is something that India has also been concerned about for some time," says Arunabha Ghosh, founder-CEO of the policy research institution Council on Energy, Environment and Water. Higher temperatures increase the activity, reproduction and frequency of the so-called blood meals of these vectors. These pathogens, harboured by mosquitoes, for instance, also mature faster, resulting in more rapid expansion and increased intensity of disease," he says during a video call.

The notion that warmer temperatures could have an adverse effect on the covid-19 virus was debunked earlier this month when Harvard researchers warned in a study that the virus might not fade away in warmer weather.

Rainfall patterns have similar effects on certain diseases. Dengue fever, chikungunya, Zika and Rift Valley fever are known to spread during periods of heavy rain and flooding, which result in greater vector capacity. The point is to keep looking at the non-linear risk of climate change because there is no flattening of the curve here," adds Ghosh. Warm climate keeps becoming warmer and thats what we have to prepare ourselves for."

FLIGHT AS FEVER

In the past, researchers have traced the origins of some of the deadliest animal-borne disease outbreaks (Marburg virus, Ebolavirus, SARS virus, Nipah, novel coronavirus, or SARS-CoV-2) to one source: bats. But how do bats survive so many viruses in their bodies?

A study published in February in the scientific journal eLife by researchers at the University of California, Berkeley explains how fierce immune systems in bats drive viruses to higher virulence, making them deadlier in humans who have a relatively tamer" immune system.

Rohit Chakravarty, a bats researcher and doctoral candidate at the Leibniz Institute for Zoo and Wildlife Research in Germany, explains how viruses mutate among bat species. Bats are really diverse. There are more than a thousand species with their own natural histories, lifestyles. India alone has about 128 bat species," he says. Sometimes, a lot of the species roost together in a cave. When all these species, with different diets and exposure to different viruses, come together and group in one cave (or other natural settings), it is very easy for viruses to keep mutating," he adds.

In April, an Indian Council of Medical Research study found coronaviruses in two local bat speciesthe Indian flying fox and Rousettusbased on swab samples from 25 bats from these two species in Kerala, Tamil Nadu, Puducherry and Himachal Pradesh. It noted there was no relation between these coronaviruses and the covid-19 virus, or any evidence that these viruses could be transmitted to humans. Coronaviruses are a large family of hundreds of viruses that circulate among certain animals but sometimes jump to humans.

Aaron T. Irving, a senior research fellow at the Duke-NUS Medical School in Singapore, says much of the problem is the human immune system: Its overreacting and killing us". The SARS-CoV-2 virus causes fatal inflammatory responses and acute lung injury in humans. Bat immune systems have a very strong primary antiviral response but they seem to prevent excessive inflammation. They block cytokine storms that are commonly seen in humans and prevent a massive recruitment of immune cells to where the virus is. This means bats tightly regulate their immune system to prevent it going into overdrive," adds Irving, who focuses on bat immunology.

Another hypothesis explains how the ability to fly protects bats: in other words, flight as fever". Their metabolic rates increase in flight and the rigorous physical activity results in a rapid rise in body temperature, similar to the fever we experience when our immune system is trying to ward off an infection.

Yet Chakravarty believes it is important not to forget the role of anthropogenic pressures. When animals are stressed and driven out of their natural comfort zones, their immune systems stop functioning efficiently, which means they are more likely to get infected and then pass on viruses to humans.

Arinjay Banerjee, a postdoctoral researcher at McMaster Universitys Institute for Infectious Disease Research in Canada, says it would not be fair to describe bats as reservoirs of deadly viruses. Banerjee is part of a Canadian research team that last month successfully isolated and cultured the covid-19 virus in a high containment laboratorya big step towards understanding more about the virus biology and developing a vaccine.

Banerjee believes this outbreak stresses the need to understand disease ecology and transmission of pathogens from animals. The unfortunate thing about this coronavirus is that it is more easily transmissible. SARS and MERS have higher mortality rates but they never infected as many people as SARS-CoV-2," he says. We need to be prepared for future outbreaks once we have dealt with covid-19."

Initiatives like the Global Virome Project are already working on understanding how and where the next viral outbreak might come from (GVP is a 10-year scientific effort of public, private and philanthropic organizations to discover zoonotic viral threats). Only by understanding virus diversity and the associated transmission risks may we move from constantly reacting and responding to epidemics to preventing epidemics," says Jonna Mazet, a member and implementation director of the GVP leadership board.

On email, Mazet explains that in seeking out viruses, the project is also strengthening country capabilities to detect and control viral spillover, by improving surveillance, biosecurity and laboratory capacity.

History offers an example. In the 1960s, researchers described the first human coronaviruses HCoV-229E and HCoV-OC43, which were studied extensively till the mid-1980s. They caused a worrying infection that is known to us today as the common cold.

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When a virus jumps: of man, microbes and pandemics - Livemint

How coronavirus behaves in body and why Covid-19 is difficult to treat – India Today

Viruses are strange creatures. They are not even a complete cell that school textbooks describe as the basic unit of life. Viruses are a chemical compounds made up of only a handful of molecules.

These molecules arrange themselves in different orders to form various types of shapes. In the case of the novel coronavirus, these molecules make a sparkling red ball with crowns - giving identity to the family of coronavirus.

They are very, very small in size compared to their pathogenic cousins such as bacteria and fungi. They prey on almost any living organism. Some viruses infect other pathogens and make them sick. Bacteriophage is an excellent example. It infects and kills bacteria. Bacteriophage is considered as the reason why River Ganga water remained relatively bacteria-free before humans exceeded their capacity to keep the river water clean.

Coming back to viruses, they are so simple that most scientists don't even categorise them as living beings. Remember, school textbooks called them the link between the living and the non-living.

The novel coronavirus, scientifically named as SARS-CoV-2, is a comparatively large virus. Its size is about 120 nanometres - four times that of the poliovirus, which is just 30 nanometres. But a harmless Escherichia coli bacteria - the ones present in our gut - is some 16 times the size of the novel coronavirus. An average red blood cell in our body is about 64 times larger than the novel coronavirus.

The key molecule in all viruses including coronaviruses is protein. These are genetic materials and a storehouse of a very limited set of instructions - like a specific software programme. When these viruses get a favourable environment - namely, the body fluid - they start replicating themselves. This is their reproduction. They enter a cell and eat it from inside. When they leave the cell, they are in millions and the host cell is nothing more than garbage.

This is the way they wreak havoc among species including humans and crops. They are very smart and can travel through air, water, soil, droplets and from one person to other person. Through human-to-human transmission via saliva or mucous droplets, the novel coronavirus spread to all corners of the world after emerging from Wuhan in China. It took humans for a ride, literally.

Now, let's take a look at how the novel coronavirus behaves in our body. Proteins are crucial for the functioning of any living body. They don't only build muscles but they also establish the communication network within the body system. What is required, where and when, and how an issue inside the body is to be fixed is done by these proteins -- specifically, mRNA (messenger RNA), which perform the sentry's role in the body.

It is this variety of protein that keeps SARS-CoV-2 going. Typically, a human cell uses about 20,000 different types of proteins. Viruses use much less. For example, an HIV -- one that causes AIDS -- uses only 15 proteins to do its work. The novel coronavirus deploys 33, that too with the small size of its body.

Larger pathogens such as bacteria offer extra body space for medicines like antibiotics to block them from reproducing. The bacteria can be easily identified by antibiotics-induced antibodies as they flood outside the human cells. This behaviour makes them a suitable target for antibiotics/antibodies.

However, no antibiotic drug works on viruses because these germs don't reproduce on their own. They hijack the human host cell's physiology -- the miniature biological factory -- to make their Xerox copies. They leave one cell to invade millions others. They are always hidden. It is hard for medicine shots to kill viruses without damaging the body cells these pathogens have taken hostage.

There is another problem why treating viral diseases including Covid-19 is a bigger challenge. The viruses keep evolving almost continuously, but not significantly enough to be categorised as mutation. It is like changing clothes frequently.

This behaviour of virus confuses our immune system, whose responsibility is to detect the virus and neutralise the enemy. What happens often is that by the time the body's immune system detects the virus, the damage has already been done, and infection has transmitted to other person or persons.

Many a time, when body prepares for the fight with the invading virus -- the point when fever and other symptoms start showing up, the enemy is already on its way out after demolishing the fortresses of defence.

Doctors say the symptoms of fever etcetera are sometimes actually the response of the immune system rather than the virus. This is a stage where it may be too late for a patient. This is what is being seen in Covid-19 cases. A large number of Covid-19 patients died within 48 hours of their admission in a hospital. Those who were diagnosed earlier got well faster.

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How coronavirus behaves in body and why Covid-19 is difficult to treat - India Today

Circles and Squares by Caroline Maclean review the Hampstead modernists – The Guardian

In 1937 the art critic Myfanwy Evans published The Painters Object, an anthology of new essays by leading artists of the day including Pablo Picasso, Wassily Kandinsky and Paul Nash. While Evanss aim was to present a snapshot of contemporary practice, its clear from her introduction that she wasnt holding out for consensus. In fact, she suggested, the art world was currently in the middle of a series of all-encompassing battles between Hampstead, Bloomsbury, surrealist, abstract, social realist, Spain, Germany, heaven, hell, paradise, chaos, light, dark, round, square.

Evanss breathless list was meant to be playful, but she was making a serious point. Within the broad church of modernism, you could find the cool abstract grids of Piet Mondrian, the increasingly politically engaged style of Picasso or, more recently, the curve ball of surrealism, as represented by Salvador Dal and his lobster telephone. What made the struggle for dominance more intense is that much of it was being played out within a few streets around Hampstead and neighbouring Belsize Park in north-west London.

It wasnt simply that British artists including Henry Moore and Nash had piled into NW3, attracted by cheap studio space and good northern light. It was that the area was increasingly home to distinguished migrs, driven out of Europe by the Nazis conviction that modernisms machine-tooled, mass-produced aesthetic was the product of a covert communism. Following the closure of the Bauhaus in 1933, many of the influential art schools faculty, including Walter Gropius, Marcel Breuer and Lszl Moholy-Nagy had taken refuge in the Isokon building, a sleek new residential complex on Lawn Road in Hampstead that was the closest that British architecture ever got to the modernist ideal of a machine for living.

Above all, Evans understood that the current culture wars involved not just ideologies and manifestos but flesh-and-blood people. She knew all about the drunken japes, open marriages, shabby accommodation, ecstatic assignations and slow wars of attrition through which art got made in the 1930s. An affair with another painter, for instance, might bring someone towards a new way of seeing, while a feud with a flatmate could result in a sculptors violent change of direction. Artists continued to produce work in the midst of babies arriving, holiday leases being taken, motor cars giving up the ghost, savings running dry. And it is this human story or rather these stories that Caroline Maclean delivers in this hugely enjoyable and well-plotted book.

A good place to start is with Evans herself, quite possibly the only bona fide Hampstead native in this story. As a clever Oxford undergraduate she had admired the published art criticism of a young unknown painter called John Piper. Invited by friends for a weekend on the Suffolk coast then, as now, an outpost of north London Evans was picked up at the station by a fellow house guest who took her straight to the beach for a swim. He turned out to be Piper and they lived happily ever after, at least once hed obtained a divorce from his painter wife who was already in love with someone else. Modernist life, unlike its art, never ran in straight lines.

Together and separately John and Myfanwy Piper worked through the implications of the move towards pure form that they witnessed in the work of contemporaries including Barbara Hepworth, Ben Nicholson and Nash. The Pipers worried that their erstwhile friends lofty, depersonalised approach to object and image-making actually constituted a political dereliction in these increasingly desperate times. In The Painters Object, Myfanwy included a reproduction of Picassos Guernica, which violently depicts the destruction of humanity by aerial bombardment during the Spanish civil war. Its brilliant horror was enough to nudge John Piper away from abstraction and towards a figuration of ordinary, everyday things, which he now reported seeing with a new intensity. Where once Pipers landscapes had been as spare as an architects plans, now they bristled with churches, trees and monuments all those dear sights that would soon be at risk of wartime obliteration.

More topsy-turvy is the story of Hepworth and Nicholson how the sculptor and the painter met when married to other people and how they tried their best, as civilised people (not to mention positive-minded Christian Scientists), to avoid causing emotional pain. Inevitably, however, their inability to take decisive action resulted in extra suffering all round. Nicholsons discarded wife Winifred behaved like an absolute dear, according to Barbara, who suggested that the two women should live together and welcome periodic visits from the man whom they both loved. Nicholson, conveniently, believed that as long as he stayed true to his own desires then happiness would automatically follow for everyone else.

Despite all the comings and goings, all three artists found time to practise their tennis, with Winifred perfecting what Ben called a very pretty stroke. What really threw a spanner in the works was the birth of triplets to Ben and Barbara in 1934. This was the sort of corporeal reality that abstract artists might find difficult to absorb. Who was going to look after the babies while Ben developed his constructivist painting and Barbara concentrated on her pebble-smooth sculptures? The nanny, of course. One of the happier results of the flatlined economy of the 1930s was that there was always a local girl around whether you were in Hampstead or St Ives, to mop floors and wipe noses.

Circles and Squares is a skilful work of synthesis, which draws on the piles of biographies that already exist of the principals and supporting players. Given the huge cast of characters, it is perhaps inevitable that there are times when the narrative starts to sound like a boho court circular, an endless list of who has left for the south of France and who has turned up for dinner. But Maclean never forgets that ordinary life matters too. Someone takes the No 24 bus into town, while Jack Pritchard, co-designer of the Isokon building, quarrels with his architectural partner Wells Coates over where the bins are to go.

Circles and Squares: The Lives and Art of the Hampstead Modernists is published by Bloomsbury (RRP 30).

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Circles and Squares by Caroline Maclean review the Hampstead modernists - The Guardian

David Harvey: We Need a Collective Response to the Collective Dilemma of Coronavirus – Jacobin magazine

I write this in the midst of the coronavirus crisis in New York City. It is a difficult time to know exactly how to respond to what is happening. Normally in a situation of this kind, we anti-capitalists would be out on the streets, demonstrating and agitating.

Instead, I am in a frustrating position of personal isolation, at a moment when the time calls for collective forms of action. But as Karl Marx famously put it, we cannot make history under circumstances of our own choosing. So we have to figure out how best to make use of the opportunities we do have.

My own circumstances are relatively privileged. I can continue to work, but from home. I have not lost my job, and I still get paid. All I have to do is to hide away from the virus.

My age and gender put me in the vulnerable category, so no contact is advised. This gives me plenty of time to reflect and write, in between Zoom sessions. But rather than dwelling upon the particularities of the situation here in New York, I thought I might offer some reflections on possible alternatives and ask: How does an anti-capitalist think about circumstances of this kind?

I begin with a commentary that Marx makes on what happened in the failed revolutionary movement of the Paris Commune of 1871. Marx writes:

The working class did not expect miracles from the Commune. They have no ready-made utopias to introduce by decree of the people. They know in order to work out their own emancipation and along with it that higher form to which present society is irresistibly trending by its own economical agencies, they will have to pass through long struggles, through a series of historic processes transforming circumstances and men. They have no ideals to realize but to set free the elements of the new society with which old collapsing bourgeois society itself is pregnant.

Let me make some comments on this passage. First, of course, Marx was somewhat antagonistic to the thinking of the socialist utopians, of which there were many in the 1840s, 50s and 60s in France. This was the tradition of Joseph Fourier, Henri de Saint-Simon, tienne Cabet, Louis Auguste Blanqui, Pierre-Joseph Proudhon, and so on.

Marx felt that the utopian socialists were dreamers, and that they were not practical workers who were going to actually transform the conditions of labor in the here and now. In order to transform conditions here and now, you needed a good grasp on exactly what the nature of capitalist society is about.

But Marx is very clear that the revolutionary project must concentrate on the self-emancipation of the workers. The self part of this formulation is important. Any major project to change the world will also require a transformation of the self. So workers would have to change themselves, too. This was very much on Marxs mind at the time of the Paris Commune.

However, he also notes that capital itself is actually creating the possibilities for transformation, and that through long struggles, it would be possible to set free the lineaments of a new society in which the workers could be released from alienated labor. The revolutionary task was to set free the elements of this new society, already existing within the womb of an old collapsing bourgeois social order.

Now, lets agree that were living in a situation of an old, collapsing bourgeois society. Clearly, its pregnant with all kinds of ugly things like racism and xenophobia that I dont particularly want to see set free. But Marx is not saying set free all and everything inside of that old and awful collapsing social order. What hes saying is that we need to select those aspects of the collapsing bourgeois society that will contribute to the emancipation of the workers and the working classes.

This poses the question: What are those possibilities, and where are they coming from? Marx does not explain that in his pamphlet on the Commune, but much of his earlier theoretical work had been dedicated to revealing exactly what the constructive possibilities for the working classes might be. One of the places where he does this at great length is in the very large, complex, and unfinished text called the Grundrisse, which Marx wrote in the crisis years of 185758.

Some passages in that work shed light on exactly what it is that Marx might have had in mind in his defense of the Paris Commune. The idea of setting free relates to an understanding of what was then going on inside a bourgeois, capitalist society. This is what Marx was perpetually struggling to understand.

In the Grundrisse, Marx dwells at length upon the question of technological change and the inherent technological dynamism of capitalism. What he shows is that capitalist society, by definition, is going to be heavily invested in innovation, and heavily invested in the construction of new technological and organizational possibilities. And that is because, as an individual capitalist, if Im in competition with other capitalists, I will get an excess profit if my technology is superior to that of my rivals. Thus, every individual capitalist has an incentive to search for a more productive technology than those used by other firms with which that capitalist is competing.

For this reason, technological dynamism is embedded within the heart of a capitalist society. Marx recognized this from the Communist Manifesto (written in 1848) onward. This is one of the prime forces that explains the permanently revolutionary character of capitalism.

It will never rest content with its existing technology. It will constantly seek to improve it, because it will always reward the person, the firm, or the society that has the more advanced technology. The state, nation, or power bloc that possesses the most sophisticated and dynamic technology is the one that is going to lead the pack. So technological dynamism is built into the global structures of capitalism. And thats been the case since the very beginning.

Marxs perspective on this is both illuminating and interesting. When we imagine the process of technological innovation, we typically think of somebody making something or other and seeking out a technological improvement in whatever it is that theyre making. That is, the technological dynamism is specific to a particular factory, a particular production system, a particular situation.

But it turns out that many technologies actually spill over from one sphere of production to another. They become generic. For instance, computer technology is available to anybody who wants to use it for whatever purpose. Automating technologies are available to all kinds of people and industries.

Marx notices that by the time you get to the 1820s, 30s, and 40s in Britain, the invention of new technologies had already become an independent and freestanding business. That is, its no longer somebody whos making textiles or something like that who is interested in the new technology that will increase the productivity of the labor they employ. Instead, entrepreneurs come up with a new technology that can be used all over the place.

The prime initial example of this in Marxs time was the steam engine. It had all of these different applications, from drainage of water out of the coal mines to making steam engines and building railroads, while also being applied to the power looms in the textile factories. So if you wanted to go into the business of innovation, then engineering and the machine tool industry were good places to start.

Whole economies such as that which arose around the city of Birmingham, which specialized in machine toolmaking became oriented to the production of not only new technologies, but also new products. Even in Marxs time, technological innovation had become a freestanding business in its own right.

In the Grundrisse, Marx explores in detail the question of what happens when technology becomes a business, when innovation creates new markets, rather than functioning as a response to a specific, preexisting market demand for a new technology. New technologies then become a cutting edge of the dynamism of a capitalist society.

The consequences are wide-ranging. One obvious result is that technologies are never static: theyre never settled, and they quickly become obsolete. Catching up with the latest technology can be stressful and costly. Accelerating obsolescence can be disastrous for existing firms.

Nevertheless, whole sectors of society electronics, pharmaceuticals, bioengineering and the like are given over to creating innovations for the sake of innovation. Whoever can create the technological innovation that is going to capture the imagination, like the cell phone or the tablet, or have the most varied applications, like the computer chip, is likely to win out. So this idea that technology itself becomes a business becomes absolutely central in Marxs account of what a capitalist society is about.

This is what differentiates capitalism from all other modes of production. The capacity to innovate has been omnipresent in human history. There were technological changes in ancient China, even under feudalism. But what is unique within a capitalist mode of production is the simple fact that technology becomes a business, with a generic product that is sold to producers and consumers alike.

This is very specific to capitalism. This becomes one of the key drivers of how capitalist society evolves. This is the world we live in, whether we like it or not.

Marx goes on to point out a very significant corollary of this development. In order for technology to become a business, you need to mobilize new forms of knowledge in certain ways. This entails the application of science and technology as distinctive understandings of the world.

The creation of new technologies on the ground becomes integrated with the rise of science and technology as intellectual and academic disciplines. Marx notices how the application of science and technology, and the creation of new forms of knowledge, become essential for this revolutionary technological innovation.

This defines another aspect of the nature of a capitalist mode of production. Technological dynamism is connected to a dynamism in the production of new scientific and technical knowledge and new, often revolutionary mental conceptions of the world. The fields of science and technology mesh with the production and mobilization of new knowledge and understandings. Eventually, wholly new institutions, like MIT and Cal Tech, had to be founded to facilitate this development.

Marx then goes on to ask: What does this do to the production processes within capitalism, and how does it affect the way in which labor (and the worker) is incorporated into these production processes? In the pre-capitalist era, say the fifteenth and sixteenth centuries, the laborer generally had control of the means of production the necessary tools and became skilled in the utilization of these tools. The skilled laborer became a monopolist of a certain kind of knowledge and certain kind of understanding that, Marx notes, was always considered an art.

However, by the time you get to the factory system, and even more so by the time you get to the contemporary world, that is no longer the case. The traditional skills of laborers are rendered redundant, because technology and science take over. Technology and science and new forms of knowledge are incorporated into the machine, and the art disappears.

And so Marx, in an astonishing set of passages in the Grundrisse pages 650 to 710 of the Penguin edition, if you are interested talks about the way that new technologies and knowledge become embedded in the machine: theyre no longer in the laborers brain, and the laborer is pushed to one side to become an appendage of the machine, a mere machine-minder. All of the intelligence and all of the knowledge, which used to belong to the laborers, and which conferred upon them a certain monopoly power vis--vis capital, disappear.

The capitalist who once needed the skills of the laborer is now freed from that constraint, and the skill is embodied in the machine. The knowledge produced through science and technology flows into the machine, and the machine becomes the soul of capitalist dynamism. That is the situation Marx is describing.

The dynamism of a capitalist society becomes crucially dependent upon perpetual innovations, driven by the mobilization of science and technology. Marx saw this clearly in his own time. He was writing about all of this in 1858! But right now, of course, were in a situation where this issue has become critical and crucial.

The question of artificial intelligence (AI) is the contemporary version of what Marx was talking about. We now need to know to what degree artificial intelligence is being developed through science and technology, and to what degree it is being applied (or likely to be applied) in production. The obvious effect would be to displace the laborer, and in fact disarm and devalue the laborer even further, in terms of the laborers capacity for the application of imagination, skill, and expertise within the production process.

This leads Marx to make the following commentary in the Grundrisse. Let me cite it to you, because I think its really, really fascinating:

The transformation of the production process from the simple labor process into a scientific process, which subjugates the forces of nature and compels them to work in the service of human needs, appears as a quality of fixed capital in contrast to living labor ... thus all powers of labor are transposed into powers of capital.

The knowledge and scientific expertise now lies within the machine under the command of the capitalist. The productive power of labor is relocated into the fixed capital, something that is external to labor. The laborer is pushed to one side. So fixed capital becomes the bearer of our collective knowledge and intelligence when it comes to production and consumption.

Further on, Marx homes in on what it is that the collapsing bourgeois order is pregnant with that might redound to the benefit of labor. And its this: capital quite unintentionally reduces human labor, expenditure of energy to a minimum. This will redound to the benefit of emancipated labor and is the condition of its emancipation. In Marxs view, the rise of something like automation or artificial intelligence creates conditions and possibilities for the emancipation of labor.

In the passage I cited from Marxs pamphlet on the Paris Commune, the issue of the self-emancipation of labor and of the laborer is central. That condition is something that needs to be embraced. But what is it about this condition that makes it so potentially liberatory?

The answer is simple. All of this science and technology is increasing the social productivity of labor. One laborer, looking after all of those machines, can produce a vast number of commodities in a very short order of time. Here again is Marx in the Grundrisse:

To the degree that large industry develops, the creation of real wealth comes to depend less on labour time and on the amount of labour employed than on the power of the agencies set in motion during labour time, whose powerful effectiveness is itself in turn out of all proportion to the direct labour time spent on their production, but depends rather on the general state of science and on the progress of technology, or the application of this science to production ... real wealth manifests itself, rather and large industry reveals this in the monstrous disproportion between the labour time applied, and its product.

But then and here Marx quotes one of the Ricardian socialists writing at that time he adds the following: Truly wealthy a nation, when the working day is 6 rather than 12 hours. Wealth is not command over surplus labour time ... but rather disposable time outside that needed in direct production, for every individual and the whole society.

It is this that leads capitalism to produce the possibility for the free development of individualities, including that of the workers. And, by the way, Ive said this before, but Im going to say it again: Marx is always, always emphasizing that its the free development of the individual which is the endpoint of what collective action is going to push for. This common idea that Marx is all about collective action and the suppression of individualism is wrong.

Its the other way around. Marx is in favor of mobilizing collective action in order to gain individual liberty. Well come back to that idea in a moment. But its the potential for the free development of individualities that is the crucial objective here.

All of this is predicated upon the general reduction of the necessary labor, that is, the amount of labor that is needed to reproduce the daily life of society. The rising productivity of labor will mean that the basic needs of society can be taken care of very easily. This will then allow abundant disposable time for the potential artistic and scientific development of individuals to be set free.

At first, this will be time for a privileged few, but ultimately, it will create free disposable time for everyone. That is to say, setting free individuals to do what they want is critical, because you can take care of the basic necessities by use of sophisticated technology.

The problem, says Marx, is that capital itself is a moving contradiction. It presses to reduce labor time to a minimum while it posits labor time on the other side as a sole measure and source of wealth. Hence it diminishes labor time in the necessary form that is, what is really necessary to increase it in the superfluous form.

Now, the superfluous form is what Marx calls surplus value. The question is, who is going to capture the surplus? The problem that Marx identifies is not that the surplus is unavailable, but that it is not available to labor. While the tendency on the one side is to create disposable time, on the other it is to convert it into surplus labour for the benefit of the capitalist class.

It is not actually being applied to the emancipation of the laborer when it could be. Its being applied to the feathering of the nests of the bourgeoisie, and therefore to the accumulation of wealth through traditional means within the bourgeoisie.

Heres the central contradiction. Truly, Marx says, the wealth of a nation. How would we understand that? Well, he says, you can understand it in terms of the mass of money and all the rest of it that somebody commands. But for Marx, as we have seen, a truly wealthy nation is one in which the working day is six rather than twelve hours. Wealth is not command over surplus labor time but rather disposable time outside that needed in direct production for every individual in the whole society.

That is: the wealth of a society is going to be measured by how much disposable free time we all have, to do whatever the hell we like without any constraints, because our basic needs are met. And Marxs argument is this: you need to have a collective movement to make sure that kind of society can be constructed. But what gets in the way is, of course, the fact of the dominant class relation, and the exercise of capitalist class power.

Now, theres an interesting echo of all this in our current situation of lockdown and economic collapse as a consequence of the coronavirus. Many of us are in a situation where, individually, we have a lot of disposable time. Most of us are stuck at home.

We cant go to work; we cant do things that we normally do. What are we going to do with our time? If we have kids, of course, then we have quite a bit to do. But weve arrived at this situation in which we have significant disposable time.

The second thing is that, of course, we are now experiencing mass unemployment. The latest data suggested that, in the United States, something like 26 million people have lost their jobs. Now, normally one would say this is a catastrophe, and, of course, it is a catastrophe, because when you lose your job, you lose the capacity to reproduce your own labor power by going to the supermarket, because you have no money.

Many people have lost their health insurance, and many others are having difficulty accessing unemployment benefits. Housing rights are in jeopardy as rents or mortgage payments fall due. Much of the US population perhaps as many as 50 percent of all households have no more than $400 of surplus money in the bank to deal with small emergencies, let alone a full-blown crisis of the sort we are now in.

These people are likely to be hitting the streets very soon, with starvation staring them and their kids in the face. But lets look more deeply at the situation.

The workforce that is expected to take care of the mounting numbers of the sick, or to provide the minimal services that allow for the reproduction of daily life, is, as a rule, highly gendered, racialized, and ethnicized. This is the new working class that is at the forefront of contemporary capitalism. Its members have to bear two burdens: at one and the same time, they are the workers most at risk of contracting the virus through their jobs, and of being laid off with no financial resources because of the economic retrenchment enforced by the virus.

The contemporary working class in the United States comprised predominantly of African Americans, Latinos, and waged women faces an ugly choice: between suffering contamination in the course of caring for people and keeping key forms of provision (such as grocery stores) open, or unemployment with no benefits (like adequate health care).

This workforce has long been socialized to behave as good neoliberal subjects, which means blaming themselves or God if anything goes wrong, but never daring to suggest that capitalism might be the problem. But even good neoliberal subjects can see that there is something wrong with the response to this pandemic, and with the disproportionate burden they must bear of sustaining the reproduction of the social order.

Collective forms of action are required to get us out of this serious crisis in dealing with COVID-19. We need collective action to control its spread lockdowns and distancing behaviors, all of those kinds of things. This collective action is necessary to eventually free us up as individuals to live the way we like, because we cannot do what we like right now.

This turns out to be a good metaphor for understanding what capital is about. It means creating a society in which most of us are not free to do what we want, because we are actually taken up with producing wealth for the capitalist class.

What Marx might say is, well, maybe those 26 million unemployed people, if they could actually find some way of getting enough money to support themselves, buy the commodities they need to survive, and rent the house in which they need to live, then why wouldnt they pursue mass emancipation from alienating work?

In other words, do we want to come out of this crisis by simply saying that theres 26 million people who need to get back to work, in some of those pretty awful jobs they may have been doing before? Is that how we want to come out of it? Or do we want to ask: Is there some way to organize the production of basic goods and services so that everybody has something to eat, everybody has a decent place to live, and we can put a moratorium on evictions, and everybody can live rent free? Isnt this moment one where we could actually think seriously about the creation of an alternative society?

If we are tough and sophisticated enough to cope with this virus, then why not take on capital at the same time? Instead of saying we all want to go back to work and get those jobs back and restore everything to the way it was before this crisis started, maybe we should say: Why dont we come out of this crisis by creating an entirely different kind of social order?

Why dont we take those elements with which the current collapsing bourgeois society is pregnant its astonishing science and technology and productive capacity and liberate them, making use of artificial intelligence and technological change and organizational forms so that we can actually create something radically different than anything that existed before?

After all, in the midst of this emergency, we are already experimenting with alternative systems of all sorts, from the free supply of basic foods to poor neighborhoods and groups, to free medical treatments, alternative access structures through the internet, and so on. In fact, the lineaments of a new socialist society are already being laid bare which is probably why the right wing and the capitalist class are so anxious to get us back to the status quo ante.

This is a moment of opportunity to think through what an alternative might look like. This is a moment in which the possibility of an alternative actually exists. Instead of just reacting in a knee-jerk manner and saying, Oh, weve got to get those 26 million jobs back immediately, maybe we should look to expand some of the things that are already going on, such as the organization of collective provision.

This is already happening in the field of health care, but it is also beginning to happen through the socialization of food supply and even cooked meals. In New York City right now, several restaurant systems have remained open, and thanks to donations, theyre actually providing free meals to the mass of the population that has lost its jobs and cant get around.

Instead of saying, Well, okay, this is just what we do in an emergency, why dont we say, this is the moment when we can start to tell those restaurants, your mission is to feed the population, so that everybody has a decent meal at least once or twice a day.

And we already have elements of that society here: a lot of schools provide school meals, for example. So lets keep that going, or at least learn the lesson of what might be possible if we cared. Isnt this a moment where we can use this socialist imagination to construct an alternative society?

This is not utopian. This is saying, all right, look at all those restaurants on the Upper West Side that have closed and are now sitting there, kind of dormant. Lets get the people back in they can start producing the food and feed the population on the streets and in the houses, and they can give it to the old people. We need that kind of collective action for all of us to become individually free.

If the 26 million people now unemployed have to go back to work, then maybe it should be for six rather than twelve hours a day, so we can celebrate the rise of a different understanding of what it means to live in the wealthiest country in the world. Maybe this is what might make America truly great (leaving the again to rot in the dustbin of history).

This is the point that Marx is making again and again and again: that the root of real individualism and freedom and emancipation, as opposed to the fake one that is constantly preached in bourgeois ideology, is a situation where all of our needs are taken care of through collective action, so that we only have to work six hours a day, and we can use the rest of the time exactly as we please.

In conclusion, isnt this an interesting moment to really think about the dynamism and the possibilities for construction of an alternative, socialist society? But in order to get onto such an emancipatory path, we first have to emancipate ourselves to see that a new imaginary is possible alongside a new reality.

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David Harvey: We Need a Collective Response to the Collective Dilemma of Coronavirus - Jacobin magazine

Westworld Season 3 Is Copying The Original Movies Super Weird Sequel – Screen Rant

Westworld season 3 takes the story to the outside world, where Dolores (Evan Rachel Wood) is executing a plan that's very similar to the original 1976 Westworld sequel, Futureworld. At the end of season 2, Dolores put a version of her own mind inside a copy of Charlotte Hale's (Tessa Thompson) body for the purposes of smuggling several "pearls" (containers for host minds) out of the park. However, in season 3 it was revealed that rather than smuggling out any other hosts, Dolores had simply made more copies of her own mind for the purposes of replacing key humans in the outside world.

Released in 1976, Futureworld was a hastily-made sequel intended to cash in on the success of the original movie. Unfortunately, Westworld's writer-director Michael Crichton wasn't interested in making a sequel, and Futureworld was instead directed by Richard T. Heffron. The film is set two years after the original, with Delos having reopened its robot-filled theme parks. Westworld has been left in ruins, and replaced by two new parks: Spaworld (where older guests can live out the fantasy of being young again) and Futureworld (which simulates life in space).

Related:Westworld Season 3 Poster Detail Teases Dolores' Death

Futureworld is a pretty weird sequel. The only returning cast member from the original movie is Yul Brynner as the Gunslinger, and he only appears for a couple of minutes as the rescuing hero in an erotic dream that TV reporter Tracy Ballard (Blythe Danner) has. The plot, however, is interesting when compared to that ofWestworld season 3. While putting together a story on the supposedly new and improved Delos parks, Tracy and her fellow reporter Chuck (Peter Fonda) discover that Delos is now being run by robots, who are inviting world leaders and other powerful figures to the parks so that they can be cloned and replaced.

These clones are human in almost every respect, but have been brainwashed to destroy their originals and carry out Delos orders. The parallels to Futureworld actually began in Westworld season 2, when it was revealed that Delos had been closely monitoring guests at the park and their behavior with the goal of ultimately making copies of their minds, like they did with James Delos. In Futureworld, the targeted visitors are under constant surveillance and their appearance and mannerisms are recorded by a team of robot scientists for the purposes of creating perfect clones of them.

The similarities between Futureworld and Westworld season 3 don't stop there. The ultimate goal of this program of cloning and replacing people is to save the planet from humanity's destructive tendencies, which was Serac's goal with the creation of Rehoboam - a supercomputer that uses mass data collection to project the future of everyone in the world, and decide which people are worthy of promotion, reproduction and social advancement, and which ones should have their lives stalled. The result is, as Caleb puts it, a world with a "coat of paint on it - but inside, it's rotting to pieces."

Unfortunately Futureworld doesn't delve as deeply into the idea of computers controlling free will as Westworld season 3 does. As in the original movie, the robots are portrayed more or less as straightforward villains, and the humans triumph over them in the end. In that sense, Westworld has an opportunity in season 3 to capitalize on an interesting idea thatdidn't get the attention it deserved in the 1976 movie. With two episodes left in season 3, it remains to be seen whether Dolores' plan to conquer the world with the strategic replacement of humans will work better than the last time it was attempted.

More:Westworld Season 3: Who Is The REAL Villain?

How Endgame's Ending Would Be Different If Captain America Did The Snap

Hannah has been with Screen Rant since the heady days of 2013, starting out as a humble news writer and eventually clawing her way up the ladder through a series of Machiavellian schemes and betrayals. She's now a features writer and editor, covering the hottest topics in the world of nerddom from her home base in Oxford, UK.Hannah enjoys weird horror movies, weirder sci-fi movies, and also the movie adaptation of Need for Speed - the greatest video game movie of all time. She has lived and studied in New York and Toronto, but ultimately returned home so that she could get a decent cup of tea. Her hobbies include drawing, video games, long walks in the countryside, and wasting far too much time on Twitter.Speaking of which, you can follow Hannah online at @HSW3K

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Westworld Season 3 Is Copying The Original Movies Super Weird Sequel - Screen Rant

Priceless poo: the global cooling effect of whales – chinadialogue ocean

The krill and plankton that form the foundation of the marine ecosystem are also being affected by the increasing acidification of the ocean. More CO2 being absorbed by the ocean means that some of these species will be unable to form and maintain their protective calcium carbonate shells, threatening key species further up the food chain. Studies show that plankton populations could decrease by as much as 40% by 2050. Coral reefs and polar regions are on the frontline of the acidification crisis, with North Pacific salmon, mackerel, herring, cod and baleen whales among the species under the most immediate threat.

Warmer seas will also affect the distribution of whales. If their prey moves as a result of climate change, they will likely follow. Mass movement of species to different habitats will result in increased competition for diminishing amounts of prey.

Toxic chemicals banned decades ago could kill off more than half of the worlds killer whale population in 30-50 years, scientists believe. PCBs (polychlorinated biphenyls) are man-made organic compounds once used in electrical equipment, flame retardants and paints until they were found to be so dangerous to human health that they were banned in the US in the 1970s and Europe in 1987. Resistant to heat, chemicals and natural degradation, the same things that made PCBs so attractive also makes them hard to destroy, and so they remain in the ecosystem decades later. Some were improperly stored or disposed of, or even directly discharged into soils, rivers, wetlands and the ocean.Entering the food chain, they have worked their way up to concentrate in top predators, causing cancers, altering behaviour, damaging immune systems and harming reproduction. European killer whale populations, along with dolphins and porpoises, are the most contaminated in the world, and some of the most heavily exposed populations are not expected to survive the next few decades.

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Priceless poo: the global cooling effect of whales - chinadialogue ocean

GICHUHI A. WAITITU – Modelling the COVID-19 Pandemic in East Africa – The Elephant

Diseases have plagued mankind throughout history. The Neolithic Revolution, which was marked by a shift to agrarian societies, preceded by hunting and gathering communities, brought about increased trading activities. The shift created new opportunities for increased human and animal interactions, which in turn, introduced and sped up the spread of new diseases. The more civilized humans became, the more the occurrences of pandemics was witnessed.

This led to outbreaks that left an indelible mark in history due to their severity. Three of the deadliest pandemics include the Plague of Justinian (541-542 BC) that killed about 30-50 million people, Black Death (1347-1351) that killed 200 million and Smallpox (1520 onwards) that killed 56 million.

Infographic courtesy: Visual Capitalist

In modern history, the most notable major pandemic was the Spanish Flu of 1918-1919. Over a century later, the world is grappling with the effects of the ongoing COVID-19 pandemic that has currently infected over 2 million people and killed over 140,000.

But how does the Spanish flu compare to the current COVID-19 pandemic?

The Spanish flu pandemic of 1918 is sometimes referred to as the mother of all pandemics. It affected one-third of the worlds population and killed up to 50 million people, including some 675,000 Americans. It was the first known pandemic to involve the H1N1 virus.

The outbreak occurred during the final months of World War I. It came in several waves but its origin, however, is still a matter of debate to-date. Its name doesnt necessarily mean it came from Spain.

An emergency hospital during Spanish flu influenza pandemic, Camp Funston, Kansas, c. 1918 Image Courtesy: National Museum of Health and Medicine

Spain was one of the earliest countries where the epidemic was identified. Historians believe this was likely a result of wartime media censorship. The country was a neutral nation during the war and did not enforce strict censorship on its press. This freedom of the press allowed them to freely publish early accounts of the illness. As a result, people falsely believed the illness was specific to Spain and hence earning the name Spanish flu.

Influenza or flu is a virus that attacks the respiratory system and is highly contagious.

Initial symptoms of the Spanish flu included a sore head and tiredness, followed by a dry hacking cough, loss of appetite, stomach problems and excessive sweating. As it progressed, the illness could affect the respiratory organs, andpneumonia could develop. This stage was often the main cause of death. This also explains why it is difficult to determine exact numbers killed by the flu, as the listed cause of death was often something other than the flu.

Thesesymptomsare very similar to those of the ongoing COVID-19 pandemic.

For decades, the Spanish flu virus was lost to history and scientists still do not know for sure where the virus originated. Several theories as to what may have caused it point to France, the United States or China.

Research published in 1999 by a British team, led by virologist John Oxford theorized a major United Kingdom staging and hospital camp in taples, France as being the centre of the flu. In late 1917, military pathologists reported the onset of a new disease with high mortality in the overcrowded camp that they later recognized as the flu. The camp was also home to a piggery, and poultry was regularly brought for food from neighbouring villages. Oxford and his team theorized that a significant precursor virus harboured in birds, mutated and then migrated to the pigs.

Other statements have been that the flu originated from the United States, in Kansas. In 2018, another study found evidence against the flu originating from Kansas, as the cases and deaths there were fewer than those in New York City in the same period. The study did, however, find evidence suggesting that the virus may have been of North American Origin, though it wasnt conclusive.

Multiple studies have placed the origin of the flu in China. The country had lower rates of flu mortality, which may have been due to an already acquired immunity possessed by the population. The argument was that the virus was imported to Europe via infected Chinese and Southeast Asian soldiers and workers headed across the Atlantic.

However, the Chinese Medical Association Journal published a report in 2016 with evidence that the 1918 virus had been circulating in the European armies for months and possibly years before the Spanish flu pandemic.

COVID-19, on the other hand, was first discovered in the Wuhan province of China late last year. There has been no argument against this so far. Research is still ongoing as to whether it was passed on from bats or the newly found connection to pangolins.

Much like COVID-19, the Spanish flu was spread from through air droplets, when an infected person sneezed or coughed, releasing more than half a million-virus particles that came into contact with uninfected people.

The close quarters and massive troop movements during the war hastened the spread of the flu. There are speculations that the soldiers already weakened immune systems were increasingly made vulnerable due to malnourishment and the stresses of combat and chemical attacks. More U.S soldiers in WW1 died from the flu than from the war.

A unique characteristic of the virus was the high death rate it caused among healthy adults 15-34 years of age. It lowered the average life expectancy in the U.S by more than 12 years.

COVID-19, on the other hand, does not discriminate in terms of age, but older people and those with other underlying medical conditions are being considered more vulnerable.

The measures being taken today to curb the spread of COVID-19 are very similar to those taken in 1918. Back then, physicians advised people to avoid crowded places and shaking hands with other people. Others suggested remedies included eating cinnamon, drinking wine and drinking Oxos beef broth. They also told people to keep their mouths and noses covered with masks in public.

Image courtesy: National Museum of Health and Medicine

In other areas quarantines were imposed and public places such as schools, theatres and churches were closed. Libraries stopped lending books and strict sanitary measures were passed to make spitting in the streets illegal.

Due to World War I, there was a shortage of doctors in some areas. Many of the physicians who were left became ill themselves. Schools and other buildings were turned into makeshift hospitals, where medical students had to step up to help the overwhelmed physicians.

Though the severity of COVID-19 has not gotten to the level of the Spanish flu, most of the effects the world is experiencing now are very relatable.

The Spanish flu killed with reckless abandon, leaving bodies piled up to such an extent that funeral parlours and cemeteries were overwhelmed. Family members were left to dig graves for their deceased loved ones. Strained state and local health centres also closed, hampering efforts to chronicle the spread of the flu and provide much-needed information to the public. Similar scenes are being witnessed in Italy today, which has so far recorded the highest number of deaths due to COVID-19.

The Spanish flu also adversely affected the economy as the deaths created a shortage of farmworkers, which in turn affected the summer harvest. A lack of staff and resources put other basic services such as waste collection and mail delivery under pressure. COVID-19 has seen some companies send their employees home on unpaid leave and others have imposed pay cuts. If the situation worsens, a majority is likely to lose their jobs.

Fake news during this time was also a problem. Even as people were dying, there were attempts to make money by advertising fake cures to desperate victims. On June 28, 1918, a public notice appeared in the British papers advising people of the symptoms of the flu. It however turned out this was actually an advertisement for Formamints, a tablet made and sold by a vitamin company. The advert stated that the mints were the best means of preventing the infective processes and that everyone, including children, should suck four or five of these tablets a day until they felt better.

Image courtesy: ICDS

Fake news has been a concern since the outbreak of COVID-19, with the Internet making it even easier to spread it. See some of our fact checks on the subjecthere.

The deadliness of WW1 coupled with censorship of the press and poor record-keeping made tracking and reporting on the virus very tedious. This explains why the flu remains of interest to date as some questions are yet to be answered. In contrast, Media coverage on COVID-19 has been commendable and very useful to the public in providing much-needed answers.

When the Spanish flu hit, medical technology and countermeasures were limited or non-existent at the time. No diagnostic tests or influenza vaccines existed. The federal government also lacked a centralized role in helping to plan and initiate interventions during the pandemic.

Many doctors prescribed medication that they felt would be effective in alleviating symptoms, including aspirin. Patients were advised to take up to 30 grams per day, a dose now known to be toxic. It is now believed that some of the deaths were actually caused or hastened by aspirin poisoning.

The first licensed flu vaccine appeared in America in the 1940s and from there on, manufacturers could routinely produce vaccines that would help control and prevent future pandemics.

Fast forward to 2020; clinical trials of COVID-19 treatments/vaccines are either ongoing or recruiting patients. The drugs being tested range from repurposed flu treatments to failed Ebola drugs, blood pressure drug (Losartan), an immunosuppressant (Actemra- an arthritis drug) and malaria treatments developed decades ago.

An antiviral drug called Favipiravir or Avigan, developed by Fujifilm Toyama Chemical in Japan is showing promising outcomes in treating at least mild to moderate cases of COVID-19.

As of now, doctors are using available drugs and health support systems such us ventilators to alleviate symptoms. There have been over 500,000 recoveries so far.

Doctors in China, South Korea, France and the U.S. have been using Chloroquine and hydroxychloroquine on some patients with promising results. The FDA is organizing a formal clinical trial of the drug, which has already been approved for the treatment of malaria, lupus and rheumatoid arthritis.

The mistakes and delays in taking quick action we are experiencing today with COVID-19 are not new. In the summer of 1918, a second wave of the Spanish flu returned to the American shores as infected soldiers came back home. With no vaccine available, it was the responsibility of the local authorities to come up with plans to protect the public, at a time when they were under pressure to appear patriotic and with a censored media downplaying the diseases spread.

Some bad decisions were made in the process. In Philadelphia for instance, the response came in too little too late. The then director of Public Health and Charities for the city, Dr Wilmer Krusen, insisted that the increasing fatalities were not the Spanish flu but the normal flu. This left 15,000 dead and another 200,000 sick. Only then did the city close down public places.

The pandemic came to an end by the end of the summer of 1919. Those who were infected either died or developed immunity. The world has experienced other flu outbreaks since then but none as deadly as the Spanish flu.

The Asian flu (H2N2), first Identified in China from 1957-1958, killed around 2 million people worldwide. The Hong Kong (H3N2), first detected in Hong Kong, from 1968-1969, killed about 1 million people. Between 1997-2003, Bird flu (H5N1), first detected in Hong Kong, killed over 300 people. More recently in 2009-2010, the Swine flu (H1N1), which originated from Mexico, killed over 18,000 people.

The worlds population has increased from 1.8 billion to 7.7 billion since 1918. Animals alike, which are used for food, have also increased significantly, giving room for more hosts for novel flu viruses to infect people. Transport systems have gotten better making global movement of people and goods much easier and faster, further widening the spread of viruses to other geographical regions.

Even though considerable medical, technological and societal advancements have been made since 1918, the best defence against the current pandemic continues to be the development of vaccine or herd immunity. The biggest challenge, however, is the time required to manufacture a new vaccine. According to the Centers for Disease Control and Prevention, CDC, it generally takes about 20 weeks to select and manufacture a new vaccine.

Dr Eddy Okoth Odari, a senior lecturer and researcher of Medical Virology in the Department of Medical Microbiology at the Jomo Kenyatta University of Agriculture and Technology breaks it down as follows:

It is anticipated that herd immunity would protect the vulnerable groups. We must, however, appreciate that natural herd immunity may only occur when a sizeable number of the population gets infected. I note with concern that we may not know and should not gamble with the immunity or health of our populations. This would then call for an induced herd immunity through vaccination. Therefore as at now, we must increase our efforts in developing an effective vaccine.

The World Health Organization (WHO) published instructions for countries to use in developing their own national pandemic plans, as well as a checklist for pandemic influenza risk and impact management. But even with all these plans, there are still loopholes that could still be devastating in the face of a pandemic, as we are currently witnessing.

Healthcare systems are getting overwhelmed and some hospitals and doctors are struggling to meet the demand from the number of patients requiring care. The manufacture and distribution of medications, products and life-saving medical equipment such as ventilators, masks and gloves have also significantly increased, seeing as there is already a shortage being experienced. Dr Okoth has a good explanation for this:

Translation of research findings into proper policies has been slow since policy formulators have insisted on evidence. For example, as early as March 2019, publications had hinted into a possibility of a virus crossing over from bats to human populations in China, but unfortunately, there was no proper preparedness and if any, perhaps the magnitude of this potential infection was underestimated. Finally, the geopolitical wars and political inclinations among the superpowers are not helping much in the war against infectious diseases. When the pandemic started it was viewed as a Chinese problem, in fact, other nations insisted in it being called a Chinese virus or Wuhan virus. Even with clear evidence that the virus would spread outside China, the WHO (perhaps to appear neutral) insisted that China was containing the virus and delayed in declaring this a pandemic the net result of this was that other countries became reluctant in upscaling their public health measures, yet other countries seem to have been keen not to be on the bad books of China.

There is no telling how long the ongoing COVID-19 pandemic will go on for or when and how it will end, but global preparation for pandemics clearly still warrant improvement as Dr Okoth advises.

Perhaps the lessons that we learn here is that diseases will not need permission to cross borders and since the world has become a global village, there should be proper investments in global health and scientific research.

This article was originally published by Africa Uncensored. Graphics by Clement Kumalija.

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GICHUHI A. WAITITU - Modelling the COVID-19 Pandemic in East Africa - The Elephant

Researchers respond to urgent call for COVID-19 testing – Greenville

(Above:Sarah Harcum making proteins with bioreactors in her lab)

By Paul Alongi

Clemson University researchers arevolunteering their time and resources as part of a statewide effort to developserologic tests that could play a key role in reigniting South Carolinaseconomy and protecting healthcare professionals on the frontlines of theCOVID-19 pandemic.

A test on track to be ready this week would beaimed at detecting antibodies that form in the bloodstream when someone hasbeen exposed to the novel coronavirus and is therefore thought to have alowered chance of re-infection.

Commercial labs are also developing the tests,but some South Carolinians are concerned that the tests will be in short supplyand that the lions share will go to larger states with more purchasing powerand more cases of COVID-19.

Clemson researchers are developing the SouthCarolina tests with colleagues from the University of South Carolina, PrismaHealth and the Medical University of South Carolina.

Delphine Dean is overseeing the Clemsonportion of the work as the Clemson lead for the states Serological Testing andDiagnostic Working Group.

Were all working on it together, said Dean,who is the Ron and Jane Lindsay Family Innovation Professor of bioengineering.Many of the barriers between institutions that sometimes slow downcollaboration have been removed. Everyone has been working around the clock tomake these things go much faster than typically happens.

Before any test is deployed, it would need tobe validated for effectiveness to meet Food and Drug Administrationregulations.

The test that will be available this week isaimed at checking healthcare professionals for antibodies. The idea is thatthose who test positive for the antibodies could be cleared to re-enter publiclife, allowing them to work with minimal concern they could come down withCOVID-19 or infect others.

About 500 to 1,000 tests could be ready as earlyas this week, less than a month since the project started, researchers said.

The two Clemson researchers working on thetest are Mark Blenner, the McQueen Quattlebaum Associate Professor of chemicaland biomolecular engineering, and Sarah Harcum, professor of bioengineering.

Blood samples would need to be tested in alab, which limits how many can be done. In a parallel effort, Clemsonresearchers are working to create tests that could take saliva, urine or bloodand show results with a color change in as little as 15 minutes, similar to ahome pregnancy test.

Researchers involved in developing those testsare: Blenner, Terri Bruce, research assistant professor of bioengineering anddirector of the Clemson Light Imaging Facility; Dean; Harcum; and R. KennethMarcus, University Professor of chemistry.

The tests would be an improvement on currentmethods. Antibody tests that check for immunity require a blood draw and areinaccurate and scarce, Blenner said. Testing directly for the virus itselfrequires an uncomfortable nasal swab and puts healthcare workers at aheightened risk of catching the virus, he said.

Martine LaBerge, the chair of Clemsonsbioengineering department, said all the researchers are volunteering theirtime, efforts and resources to help the state, as it faces the unprecedentedchallenges posed by the COVID-19 pandemic.

They are working tirelessly to protect thehealth and safety of South Carolinas healthcare professionals and the generalpublic, said LaBerge, who is playing a central role in coordinating Clemsonsresearch response to the pandemic. Institutional barriers are coming down sothat we can work together as one South Carolina. I offer all those sacrificingsleep and time with family my deepest gratitude.

The process to develop the tests starts withBlenner, who is making spike proteins, which give the novel coronavirus itsdistinguishing feature and is believed to be how the viral infection ismediated.

In his lab, Blenner puts the DNA for the spikeproteins inside of human or hamster cells. When the cells grow, they producethe spike proteins, which will ultimately serve as the key reagent in theantibody tests.

Our group is going to make a stable cell linethat we can scale up, Blenner said. Right now the procedure is not meant tomake a lot of protein. Its meant for quick protein production. Im going tomake a productive cell line and work with Sarah Harcum to get that in largerbioreactors.

Harcum said she will put the cells incomputer-controlled bioreactors that can sense oxygen and pH levels. Pumpscarefully control the nutrients that feed the cells.

I grow cells to make them happier so theymake more protein, Harcum said. Normally, I look at how to makepharmaceuticals, but the pharmaceuticals I make are proteins, which makes thisCOVID-19 work a good fit for what I do.

Once she has the protein grown, Harcum willthen purify it so that it can be used in the diagnostic tests.

Meanwhile, Bruce, Marcus and Dean are startingto lay the groundwork for simple tests that could reach large numbers ofpeople.

What we really need is something simplethats a colorimetric test that can be done in under 15 minutes at the point ofcare, Bruce said.

The team is working to improve upon acommercially-developed enzyme-linked immunoabsorbent assay, or ELISA, thatchecks blood samples for antibodies.

Antibodies are plentiful in blood but less soin saliva. One of the challenges in developing a saliva-based test is isolatingthe antibodies.

To do so, Marcus and Bruce are turning tocapillary-channeled polymer fiber-based films, a technology they have been researchingfor years.

Antibodies exist in this tremendously complexsoup, and what you would like to be able to do is pull them out of the soupselectively in a fairly high-throughput fashion, Marcus said. We can modify our fibers so that the only thingsthat stick are the antibodies.

Clemson researchers are working to make aprototype, but a manufacturer would be needed to produce large quantities ofthe test, Bruce said.

Dean, who is helping develop the opticalportion of the test, said it could also be possible to use the fibers tocapture the virus itself from urine. There is evidence that the virus comes outin urine after it is no longer detectable in blood, she said.

Patients could maybe test themselves athome, Dean said. The same principle could be used to test waste streams. Ifyou wanted to do population monitoring, you might be able to get a sense forwhat percent of the population has the virus.

Researchers said they are finding ways to payfor the development of the tests with existing funds but that eventually theywill need financial support, particularly when the semester ends next month.

We are going to need lab supplies andgraduate student salaries, and we could accelerate development by outsourcingsome of the work, Dean said. Typically, when we launch big projects, we applyfor federal funding, a process that normally takes months, if not a year ormore. But time is of the essence, and we are finding ways to quickly ramp upwork. What we need most now is the funds to help keep the work going.

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Researchers respond to urgent call for COVID-19 testing - Greenville

This ‘spray’ by IIT Guwahati can prove to be a game-changer in fight against coronavirus – Campus Varta

In the fight against the coronavirus pandemic, Indian Institute of Technology (IITs) across the country are trying their best to aid the battle against the deadly contagion. A major problem with the identification and treatment of infected patients is the lack of Personal Protective Equipment Kits (PPE). A PPE kit can also become the source of the infection if not used properly.

Now, to overcome this problem, and for the safe usage of PPE kits by doctors, Prof. Biman B. Mandalof the Department of Bioscience and Bioengineering, IIT Guwahati, has prepared a spray with his PhD scholarMr. Bibhas K. Bhunia

Professor Mandal said that the most important thing to protect against coronavirus is the face mask. It is used by doctors, healthcare professionals and common people as well for the protection against catching the virus and acts as a barrier to the virus. It helps in protecting us from various microbes. Professor Mandal said that since the mask cannot be used again, it is needed in large numbers.

At the same time, the mask or fabric if not used properly, becomes the carrier of the virus. In such a situation, the spray made by IIT is very effective. In a way, this spray acts as an additional coating, through which the PPE kit can also be used again.

Prof. Mandal said that the price of the spray prepared by IIT Guwahati is quite reasonable, as well as it has been prepared according to industry standards, so that its manufacturing will not have to undergo much changes in future. He said that we are engaged in a fight against coronavirus pandemic under the leadership of our Professor T.G. Sitharam.

How the spray works

To make the PPE kits safe, this spray is sprayed on it or you can use it by immersing it in liquid. Mandal said that exposure to this antimicrobial (antiviral / antibacterial) spray kills bacteria. The spray acts as an antimicrobial agent in the presence of a metal nanoparticle cocktail such as copper, silver, and other active elements present in the spray.

See more here:
This 'spray' by IIT Guwahati can prove to be a game-changer in fight against coronavirus - Campus Varta

Did the COVID-19 virus originate from a lab or nature? Examining the evidence for different hypotheses of the novel coronavirus’ origins – Health…

Since the beginning of the COVID-19 outbreak in December 2019, many hypotheses have been advanced to explain where the novel coronavirus (SARS-CoV-2) actually came from. Initial reports pointed to the Huanan seafood market in Wuhan, China, as the source of infection, however later studies called this into question. Given the uncertainty, many have suggested that a laboratory in Wuhan may be the actual source of the novel coronavirus. In this Insight article, we examine the three most widespread origin stories for the novel coronavirus, and examine the evidence for or against each proposed hypothesis. The hypotheses are listed in order from least likely to most likely, based on currently available evidence.

Although none of the individual pieces of evidence described below definitively identify the virus origin, the preponderance of evidence when taken together currently points to a natural origin with a subsequent zoonotic transmission from animals to humans, rather than a bioengineering or lab leak origin.

Hypothesis 1: The novel coronavirus is manmade, genetically engineered as bioweaponry or for health applications This hypothesis began circulating in February 2020. To date, it has been largely rejected by the scientific community. Some of the early claims have their roots in a preprint (a study in progress which has not been peer-reviewed or formally published) uploaded to ResearchGate by Chinese scientists Botao Xiao and Lei Xiao, who claimed that somebody was entangled with the evolution of 2019-nCoV coronavirus. In addition to origins of natural recombination and intermediate host, the killer coronavirus probably originated from a laboratory in Wuhan.

However, the only piece of evidence the authors provided to support their conclusion was the proximity of both the Wuhan Centers for Disease Control & Prevention and the Wuhan Institute of Virology (WIV) to the seafood market. The authors later withdrew their article, saying that their speculation about the possible origins was not supported by direct proofs. Copies of the original article can still be found online.

The withdrawal of the preprint did not stop this hypothesis from spreadinginstead it continued to grow in complexity, with some claiming that the virus showed signs of genetic engineering. Some of these claims were based on a preprint uploaded to BioRxiv, purporting to show that genetic material from the human immunodeficiency virus (HIV) had been inserted into the novel coronavirus.

This study was found to have significant flaws in design and execution and was also later withdrawn, as reported in our review explaining that No, HIV insertions were not identified in the 2019 coronavirus. However, the poor quality of the preprint did not prevent this baseless speculation from being promoted by blogs such as Zero Hedge, Infowars, Natural News, and even some scientists like Luc Montagnier, a French virologist who co-discovered HIV, but has recently become a promoter of numerous unsupported theories.

Indeed, scientists who examined the preprint highlighted that these so-called insertions are very short genetic sequences which are also present in many other life forms, such as the bacterium Magnetospirillum magnetotacticum, the spider Araneus ventricosus, and the parasites Cryptosporidium and Plasmodium malariae, which cause cryptosporidiosis and malaria, respectively[1,2]. Trevor Bedford, virologist at Fred Hutchinson Cancer Research Center and professor at the University of Washington, explained on Twitter that a simple BLAST of such short sequences shows [a] match to a huge variety of organisms. No reason to conclude HIV. [] These inserts are nothing of the sort proposed by the paper and instead arose naturally in the ancestral bat virus.

In other words, the sequences analyzed by the study authors were so short that it is easy to find similarities to a wide variety of organisms, including HIV. An analogy would be to search for a short and commonly-used word, like sky, in a search engine and claim that the search results show content that is identical or similar to each other solely because of that one word.

Another version of the engineered-virus story stated that a pShuttle-SN sequence is present in the novel coronavirus. The pShuttle-SN vector was used during efforts to develop candidates for a SARS vaccine[3] and was therefore used to support claims of human engineering. These claims appeared in blogs such as Infowars, Natural News, and The Epoch Times. However, analysis of the genomic sequence of the novel coronavirus showed that no such man-made sequence was present, as reported in our review.

Other claims regarding the purported manmade origins of the virus have linked it to bioweapons research. These have appeared in articles such as a 22 February 2020 story by the New York Post, which we also reviewed and scientists found to be of low scientific credibility. The article provided no evidence that the novel coronavirus is linked to bioweapons research.

On 17 March 2020, a group of scientists published findings from a genomic analysis of the novel coronavirus in Nature Medicine[4], which established that SARS-CoV-2 is of natural origin, likely originating in pangolins or bats (or both) and later developing the ability to infect humans. Their investigation focused mainly on the so-called spike (S) protein, which is located on the surface of the enveloping membrane of SARS-CoV-2. The S protein allows the virus to bind to and infect animal cells. After the 2003-2005 SARS outbreak, researchers identified a set of key amino acids within the S protein which give SARS-CoV-1 a super-affinity for the ACE2 target receptor located on the surface of human cells[5,6].

Surprisingly, the S protein of SARS-CoV-2 does not contain this optimal set of amino acids[4], yet is nonetheless able to bind ACE2 with a greater affinity than SARS-CoV-1[7]. Taken together, these findings strongly suggest that SARS-CoV-2 evolved independently of human intervention and undermine the claim that it was manmade[1]. This is because if scientists had attempted to engineer improved ACE2 binding in a coronavirus, the best strategy would have been to harness the already-known and efficient amino acid sequences described in SARS-CoV-1 in order to produce a more optimal molecular design for SARS-CoV-2. The authors of the Nature Medicine study[4] concluded that Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.

In summary, the hypothesis that the virus is manmade or engineered in any way is unsupported and inconsistent with available evidence, leading Bedford to assess the probability of this hypothesis being correct as extremely unlikely. Kristian Andersen, professor at the Scripps in San Diego declared during an online seminar, I know there has been a lot of talk about Chinese bioweapons, bioengineering, and engineering in general. All of that, I can say, is fully inconsistent with the data.

Like Andersen, other scientists have repeatedly explained that there is no evidence to support the claim that the virus was human engineered. In a statement published on 19 February in The Lancet, 27 eminent public health scientists in the U.S., Europe, the U.K., Australia, and Asia cited numerous studies from multiple countries which overwhelmingly conclude that this coronavirus originated in wildlife[8-15] as have so many other emerging pathogens.

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Hypothesis 2: The novel coronavirus is a natural virus that was being studied in the lab, from which it was accidentally or deliberately released Many have pointed out that even though the virus was unlikely engineered, it still might have been purposely or accidentally released from a lab. Claims about a possible laboratory release often point to a laboratory in China as the source, more specifically the Wuhan Institute of Virology (WIV), given that one of its laboratories studies bat coronaviruses. Similarly speculative claims have also implicated laboratories in the U.S. and Canada.

However, there is no evidence in either scientific publications or public announcements indicating that a virus resembling SARS-CoV-2 had been studied or cultured in any lab prior to the outbreak. While this of course does not rule out the possibility that scientists were working on it in secret, as of today, this claim is speculative and unsupported by evidence.

A January 2020 study in The Lancet, which found that about one-third of the initial round of infections had no connection to the Huanan seafood market[15], has been suggested as evidence that the virus may have leaked from a nearby lab. Richard Ebright, a professor of chemical biology at Rutgers, said in this CNN article:

It is absolutely clear the market had no connection with the origin of the outbreak virus, and, instead, only was involved in amplification of an outbreak that had started elsewhere in Wuhan almost a full month earlier.

Ebright also told CNN that The possibility that the virus entered humans through a laboratory accident cannot and should not be dismissed.

Nikolai Petrovsky, a professor at Flinders University who specializes in vaccine development, also supported the hypothesis that the virus could have escaped from a lab. In this article, he stated that no corresponding virus has been found to exist in nature and cited as-yet unpublished work, saying that the hypothesis is absolutely plausible. Petrovsky suggested that the virus could have escaped [the biosecure facility in Wuhan] either through accidental infection of a staff member who then visited the fish market several blocks away and there infected others, or by inappropriate disposal of waste from the facility that either infected humans outside the facility directly or via a susceptible vector such as a stray cat that then frequented the market and resulted in transmission there to humans.

Some have argued that instead of originating in nature, the virus could have been generated through simulated evolution in the lab. Christian Stevens, from the Benhur Lee lab at the Mount Sinai School of Medicine, explained in this article the extreme unlikelihood of this scenario.

Briefly, the mutations in the receptor-binding domain (RBD) of the S protein in SARS-CoV-2 resembles that of some pangolin coronaviruses. These mutations are also what make SARS-CoV-2 much better at infecting humans compared to SARS-CoV-1. Such mutations could be evolved in the lab through simulated evolution, however the likelihood of simulated natural selection stumbling on the near exact RBD from a previously unknown pangolin coronavirus is mathematically unlikely, said Stevens.

Furthermore, scientists would have had to know about these mutations in the S protein of some pangolin coronaviruses before the outbreak, and then tried to evolve a bat coronavirus with the same characteristics through animal experiments. As these mutations in pangolin coronaviruses were not identified until after the outbreak[16], it does not make sense for scientists to have performed such experiments in the lab, as there would have been little to no scientific justification for doing so.

Other considerations are the polybasic cleavage site and the O-linked glycan additions to the S protein, which have not been identified in bat betacoronaviruses nor the pangolin betacoronaviruses sampled so far. However, evidence indicates that these features are much more likely to have arisen in the presence of an immune system, suggesting that this is a natural adaptation by the virus to a live host, either an animal or a human. Because lab-based cell cultures do not have immune systems, Stevens explained that it is extremely unlikely that the virus would have developed such features using cell culture approaches, thereby undermining the lab-generated claims that some have proposed.

What about using animal models for evolution, which would provide selective pressure from an immune system? Stevens also examined this possibility and explained that there is no known animal model that would allow for selection of human-like ACE2 binding and avoidance of immune recognition. This strongly suggests that SARS-CoV-2 could not have been developed in a lab, even by a system of simulated natural selection.

In other words, the overall combination of features observed in SARS-CoV-2 is extremely unlikely to have arisen through experiments, even simulated evolution, because the experimental tools are not available at the moment.

Zhengli Shi, the head of the laboratory studying bat coronaviruses at the WIV, clarified in a Scientific American report published on 11 March, that during the early days of the outbreak, she had her team check the genome sequence of SARS-CoV-2 against the bat coronavirus strains being studied in her lab to ensure that the outbreak had not resulted from any mishandling of experimental materials, especially during disposal. They found that none of the sequences matched those of the viruses her team had sampled from bat caves.

However, this testimony has not satisfied those who allege a cover-up of a lab accident due to inadequate biosecurity, intentional release, or plain carelessness. Recent opinion pieces published by the Washington Postone on 2 April 2020 and another on 14 April 2020have also fueled speculation that the virus was accidentally released from a laboratory at the WIV due to biosafety lapses reportedly documented in diplomatic cables from 2018. The authors of these opinion pieces were careful to distance themselves from earlier claims that the coronavirus was bioengineered or resulted from deliberate wrongdoing, as one author stated. In any event, the accidental release scenario is currently being considered by scientists and U.S. intelligence and national security officials.

Indeed, despite safeguards, laboratory accidents can and do occur, and some have even caused outbreaks. In 2007, an outbreak of hand-foot-mouth (HFM) disease among livestock in the U.K. was linked to a faulty gas valve connected to labs involved in researching and producing HFM vaccines. And in 2004, a re-emergence of SARS occurred in Beijing, China, as a result of two lab accidents.

In an article published on 6 April, experts expressed skepticism at the lab leak hypothesis. Vincent Racaniello, a professor of virology at Columbia University, said I think it has no credibility. And Simon Anthony, an assistant professor at Columbia who studies the ecology and evolution of viruses, stated, it all feels far-fetched [] Lab accidents do happen, we know that, but [] theres certainly no evidence to support that theory.

In an April 10th article, Amesh Adalja from Johns Hopkins University Center for Health Security stated that he thought the lab leak hypothesis had a lower probability than the pure zoonotic theory. I think as we get a better understanding of where the origin of this virus was, and get closer to patient zero, that will explain some of the mystery. Bill Hanage, associate professor at the Harvard T.H. Chan School of Public Health, said If there is evidence to really support this theory beyond the coincidence of the location of the lab, then I havent seen it, and I dont make decisions on the basis of coincidence.

Several scientists have taken to Twitter to ponder the lab leak hypothesis made by the Washington Post opinion articles:

Overall, we have virus group, molecular features, market association, and environmental samples all pointing strongly towards zoonosis. The location in Wuhan is the only thing at all suggestive of lab escape. I see strength of evidence entirely for zoonosis.

Trevor Bedford

We dont know how this virus emerged, but all evidence points to spillover from its natural reservoir, whether that be a bat or some other intermediate species, pangolins or otherwise. Pushing this unsupported accident theory hinders efforts to actually determine virus origin.

Angela Rasmussen

The bottom line is that those vague diplomatic cables do not provide any specific information suggesting that [SARS-CoV-2] emerged from incompetence or poor biosafety protocols or anything else.

Angela Rasmussen [referencing the 14 April Washington Post opinion piece]

Most likely either 1) virus evolved to its current pathogenic state via a non-human host and then jumped to humans, or 2) a non-pathogenic version of the virus jumped from an animal into humans then evolved to a pathogenic state.

Josh Michaud

All current data supports that the ancestral station strain of the virus is in batsthey serve as the zoonotic reservoir. Then a spillover event occured into humans, perhaps aided by another mammal, although thats debatable.

Ryan McNamara

There is strong evidence that the #SARSCoV2 #coronavirus is NOT an engineered bioweapon.

That said, its important to be upfront that we do not have sufficient evidence to exclude entirely the possibility that it escaped from a research lab doing gain of function experiments.

Carl T. Bergstrom

In summary, the hypothesis that the virus escaped from a lab is supported largely by circumstantial evidence and is not supported by genomic analyses and publicly available information. In the absence of evidence for or against an accidental lab leak, one cannot rule it out as the actual source of the outbreak. I dont think we have real data to say when these things began, in large part because the data are being held back from inspection, said Gerald Keusch, associate director of the Boston University National Emerging Infectious Diseases Laboratories, in this LiveScience article.

Given allegations of a cover-up, it appears that only an open and transparent review of the laboratory activities at WIV can allow us to confirm or reject this unlikely hypothesis.

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Hypothesis 3: The novel coronavirus evolved naturally and the outbreak began through zoonotic infection Virologists explain that the most likely hypothesis is that the outbreak started with a naturally-occurring zoonotic infectionone that is transmitted from animals to humansrather than a lab breach. This is largely due to what we know of the virus genomic features, which strongly indicate a natural origin. For example, if a virus had escaped from a laboratory, its genome would likely be most similar to those of the viral strains cultured in that lab. However, as shown in this phylogenetic tree by Bedford (see figure below), SARS-CoV-2 does not cluster in the same branch as the SARS-like coronavirus WIV1 (WIV1) and SARS-CoV-1, which are commonly cultured lab strains with the closest similarity to SARS-CoV-2 at the WIV facility, which is the lab that some have suggested might be a potential source of a lab leak. Instead, SARS-CoV-2 aligns most closely with coronaviruses isolated in the wild from bats and pangolins, indicating that it is more likely to have come from a natural source than from a lab:

FigurePhylogenetic tree showing evolutionary relationships between different coronavirusesmostly bat coronaviruses and some pangolin coronaviruses (by Trevor Bedford). Different lab strains of SARS-CoV-1 (referred to as SARS-CoV here) are represented by yellow dots. WIV1, another common lab strain, is indicated with a black arrow.

Furthermore, SARS-CoV-2 displays evolutionary features which suggest that the virus originated in animals and jumped to humans. The closest sequenced ancestor of SARS-CoV-2 is RaTG13, a bat coronavirus with about 96% genome sequence identity[8]. But SARS-CoV-2 also has features that distinguish it from RaTG13 and other SARS-like coronaviruses including SARS-CoV-1. As mentioned in the previous section, these features are: mutations in the receptor binding domain (RBD) of the S protein, a polybasic cleavage site, and a nearby O-linked glycan addition site in the S protein[4]. The mutations in the RBD of the S protein resemble those of some pangolin coronaviruses, suggesting that the virus made a jump from bats to an intermediate (perhaps pangolins), and then later to humans.

To briefly re-cap from the previous section discussing the hypothesis of a lab origin, Christian Stevens explained in this article that the polybasic cleavage site and the O-linked glycan additions to the S protein have not been identified in bat betacoronaviruses nor the pangolin betacoronaviruses sampled so far. However, evidence indicates that these features are much more likely to have arisen in the presence of an immune system, suggesting that this is a natural adaptation by the virus to a live host, either an animal or a human.

And again, there is no known animal model that would allow for selection of human-like ACE2 binding and avoidance of immune recognition, Stevens explained. This strongly suggests that SARS-CoV-2 could not have been developed in a lab, even by a system of simulated natural selection. In other words, the overall combination of features observed in SARS-CoV-2 is extremely unlikely to have arisen through experiments, even simulated evolution, because the experimental tools are not available at the moment.

Finally, Christian Stevens highlighted that the Ka/Ks ratio of the virus strongly indicates that the virus did not come from lab-simulated evolution. The Ka/Ks ratio calculates the level of synonymous mutations (which do not produce any functional change in proteins) and non-synonymous mutations (which produce functional changes in proteins). Non-synonymous mutations are more likely to occur in the presence of selective pressure, such as a need to adapt to a new environment:

Because synonymous mutations should have no effect, we expect them to happen at a relatively consistent rate. That makes them a good baseline that we can compare the number of non-synonymous mutations to. By calculating the ratio between these two numbers we can differentiate between three different types of selection:

We would expect a virus that is learning to exist in a new context would be undergoing Darwinian selection and we would see a high rate of non-synonymous changes in some part of the genome. This would be the case if the virus were being designed via simulated natural selection, we would expect at least some part of the genome to show Darwinian selection.

An analysis by Bedford demonstrates that the level of non-synonymous mutations between SARS-CoV-2 and the naturally occurring RaTG13 are highly similar, standing at 14.3% and 14.2%, respectively.

Both of these numbers indicate a purifying selection, with very few non-synonymous changes. This holds true across the entire genome with no part of it showing Darwinian selection. This is a very strong indicator that SARS-CoV-2 was not designed using forced selection in a lab, Stevens concluded.

[Back to top]

Conclusions Taken together, the information presented here suggests that it is much more likely that SARS-CoV-2 was generated naturally and transmitted zoonotically, without any engineering or lab growth. Especially given the fact that the prior probability for the zoonotic hypothesis is high. Indeed, zoonotic infections (transmission of pathogens from animals/insects to humans) are not only plausible but common throughout the world, and have also caused outbreaks in the past. For example, the SARS outbreak, which began in 2002, was linked to civet cats. Outbreaks of Middle East respiratory syndrome have been linked to contact with camels. Nipah virus infection has been linked to fruit bats and caused outbreaks in Asia. Mosquitoes transmit viruses such as Zika, dengue, and chikungunya, while ticks also carry a range of pathogens, such as Lyme disease and Rocky Mountain spotted fever. In fact, according to the World Health Organization, about 60% of emerging diseases are zoonotic infections.

In summary, the hypothesis that the virus escaped from a lab is supported largely by circumstantial evidence and is not supported by publicly available information. In the case of the hypothesis that the outbreak began with zoonotic infection, at the moment genomic analyses are consistent with a natural origin for the virus and support the idea that the outbreak began zoonotically. Unlike the manmade virus and lab escape hypotheses, there is no compelling evidence against the hypothesis for natural zoonosis. As Stevens concluded, the hypothesis for natural zoonosis is the one that fits all available evidence, is most parsimonious, and best satisfies the concept of Occams Razorthat the simplest solution is most likely the right one.

[Back to top]

Christian Stevens from the Benhur Lee lab at the Mount Sinai School of Medicine has provided a comprehensive explanation of the multiple scientific studies examining the origin of the coronavirus.

Scientists explained in this 23 April NPR article why they found the lab accident hypothesis unlikely. In fact, the article states that there is virtually no chance that the new coronavirus was released as result of a laboratory accident in China or anywhere else.

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The Economic Impact of Coronavirus on Cholic Acid Market Set To Register A CAGR Growth Of XX% Over The Forecast Period 2019 2029 – Latest Herald

Given the debilitating impact of COVID-19 (Coronavirus) on the Cholic Acid market, companies are vying opportunities to stay afloat in the market landscape. Gain access to our latest research analysis on COVID-19 associated with the Cholic Acid market and understand how market players are adopting new strategies to mitigate the impact of the pandemic.

The report provides both quantitative and qualitative information of global Cholic Acid market for period of 2018 to 2025. As per the analysis provided in the report, the global market of Cholic Acid is estimated to growth at a CAGR of _% during the forecast period 2018 to 2025 and is expected to rise to USD _ million/billion by the end of year 2025. In the year 2016, the global Cholic Acid market was valued at USD _ million/billion.

This research report based on Cholic Acid market and available with Market Study Report includes latest and upcoming industry trends in addition to the global spectrum of the Cholic Acid market that includes numerous regions. Likewise, the report also expands on intricate details pertaining to contributions by key players, demand and supply analysis as well as market share growth of the Cholic Acid industry.

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The Economic Impact of Coronavirus on Cholic Acid Market Set To Register A CAGR Growth Of XX% Over The Forecast Period 2019 2029 - Latest Herald

COVID-19 push to tele-medicine, geo-fencing and surveillance – National Herald

This emerging field has, for some time past, allowed healthcare professionals to diagnose patients in remote locations over smartphones and video calls. Now, it is not only having its moment in the Sun, but fast becoming a part of daily life in the country.

Startups like Practo, Portea, and Lybate, which facilitate remote medical checkups, are witnessing a traffic bump as panicked Indians reach out to doctors over the mildest of symptoms. They are trying to keep a social distance so that the virus doesnt transmit in nursing homes, and hospital waiting rooms.

Realising its inevitability, Indias ministry of health, on the first day of the lockdown, March 25, released a 50-page document outlining new guidelines for telemedicine.

On March 29, Practo announced that residents of Mumbai could book government-authorised Coronavirus tests on its platform for Rs4,500. Four days later, rival Pristyn Care, too, partnered with over 50 laboratories across the Delhi National Capital Region, Mumbai, Bengaluru, Pune, Chennai, and Hyderabad to conduct COVID-19 detection tests.

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Exploring the use of nanobodies to help prevent diarrhea in piglets – FeedNavigator.com

The project partners include biotech company, Bactolife, Danish company, Novozymes, the Technical University of Denmark (DTU), Denmark pig research group, SEGES and Aarhus University.

The special proteins under exploration are nanobodies - these antibodies from llamas could constitute an environmentally friendly alternative to medicinal zinc added to feed rations, said the researchers.

The nanobodies are derived from antibodies found in llamas. Llamas and other animals from theCamelidaefamily produce antibodies, the binding site of which has special characteristics, they are more stable and more compact than similar proteins. They do not interact with other substances or processes in the body, and theywill most likely not lead to resistance development, said Sandra Wingaard Thrane, co-founder and senior scientist,Bactolife.

A Belgian university discovered nanobodies, but the universitys general patent to the use of them has now expired, thus allowing Bactolife to use them in its research efforts, she explained.

The project has only just got underway and has been held up, evidently, by the COVID-19 outbreak. Officially starting in February this year, it is set to run until October 2023.

In a previous project on the nanobody product, preliminary experiments were carried out in laboratories at DTU and experimental facilities at Aarhus University in Foulum.

In this project, the product will be further developed, tested in vitro, in vivo, and in a production herd for in-depth product development and definition of dosage, pricing and for final product market approval, said the team.

The Danish governments Green Development and Demonstration Program (GUDP) is providing almost 11 million DKK for the project.

Researchers from Aarhus University will carry out dosage response trials.Nuria Canibe, senior researcher, Department of Animal Science, Aarhus University, told FeedNavigator:

The nanobodies dont kill the bacteria, they bind them, that is the idea. In in-vivo studies, we will challenge the animals with ETEC and we will see whether the proteins reduce diarrhea or reduce or shorten the shedding of ETEC; we will explore several clinical aspects related to an E. coli challenge.

Initially, we will give the additive directly to animals, via their mouths, and then we will try mixing it with the feed.

Novozymes role in the project will cover production of the naobody product, the toxicity studies, and all the regulatory aspects, said Canibe.

In terms of the other collaborators, Bactolife came up with the idea, established the company and will be in charge of the development of nanobodies, while researchers from DTU Bioengineering will continue to carry out in vitro experiments in relation to the nanobodies, she explained.

In the final phase, SEGES will carry out a large on-farm study to see whether the additive really prevents diarrhea and they will also test it against piglet performance,said Canibe.

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Rice University ignites innovation in response to COVID-19 crisis – TMC News – Texas Medical Center News

The Rice University campus may be uncharacteristically quiet these days, but that doesnt mean its staff and student population are riding out the COVID-19 pandemic idly. In fact, its just the opposite.

Since March, when the university announced that classes would shift to online learning for the remainder of the semester, a host of efforts have emerged from assembling care packages for essential employees to engineering lifesaving devices and establishing new research aimed at COVID-19 solutions.

I have been amazed, but not surprised, said David Leebron, president of Rice University. People want to contribute wherever their skills are, whether its data science, sociology, understanding differential impacts, maybe even understanding the history of contagionsall things we can learn from. People all over the university, they got themselves settled, we got folks off campus and now what they want to do is say: How can we help?

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From across disciplines that appear to be unlikely partners, students and staff members have found ways to contribute. The universitys Moody Center for the Arts has transformed their studio space into a production facility for face shields for medical workers; MBA students at the Jones Graduate School of Business established a business model that provides snacks for clinicians while boosting the local economy; and the Rice Athletics staff put together generous care packages for medical workers across the Texas Medical Center as a gesture of appreciation for work on the front line.

Among one of the most innovative solutions is an automated bag valve mask ventilation unit originally designed by engineering undergraduates at the Oshman Engineering Design Kitchen (OEDK), a dedicated hub for students to design and prototype solutions for real-world engineering challenges. As news of ventilator shortages in areas hit hard by COVID-19 grew, an online video of the unit began growing in popularity, even piquing the interest of the U.S. Department of Defense and the U.S. Navy.

The students who created the original unit have graduated, so an OEDK team collaborated with global health design firm Metric Technologies and reimagined the design so that it was easier to put together as a do-it-yourself-type kit.

Our technicians got together with one whiz-kid student and decided to redesign it and make it super simple, said Amy Kavalewitz, OEDK executive director. Working with Dr. Rohith Malya from Baylor as our advisor, they redesigned it in a way where, if you had the tools and you had the equipment and you had some basic knowledge of how to build a device, you could put one of these together.

Malya, who is an assistant professor of emergency medicine at Baylor College of Medicine, an adjunct assistant professor of bioengineering at Rice, associate of theRice 360 Institute for Global Healthand a principal at Metric Technologies, worked closely with Danny Blacker, the OEDKs engineering design supervisor for the mechanical efforts, and Rice University senior Thomas Herring, who led work on the programming and electrical components.

Named the ApolloBVM (BVM stands for bag valve mask), the device is not intended to be used in place of a ventilator when one is available, but rather as a bridge device. While typical bag valve masks pump air into the lungs by hand, this device is automatedmaking it highly desirable for patients in need of continuous support.

In early April, the team published instructions for the unit online for anyone who wished to build one. The cost for the parts is less than $300. Kavalewitz said that since making the plans public, more than 2,000 people from 105 different countries have registered for the download.

In the U.S., were pretty fortunate in a lot of ways because there are a lot of people that are going to be able to generate supplement-type ventilators to help the COVID efforts here, but there is a real worry about the global impact this is havingand there are many communities with hospitals that dont have ventilators at all, Kavalewitz said. We say all the time that if this device helps one person survive, then every bit of this effort was worth it.

She added that the OEDK and Metric Technologies are looking at compiling a kit for individuals without access to the raw supplies, especially those in low-resource settings who may not have 3D printers.

To further support research across disciplines, Rice has also created a COVID-19 Research Fund to help provide grants for Rice faculty working on COVID-related work, especially efforts geared toward accelerating research or the production of materials or reagents that would have immediate impact on the Houston community. The fund hasalready awarded an initial round of grants for projects focused on developing affordable diagnostic tools, advanced surgical masks, coronavirus detection methods in wastewater and voter safety.

The university also opened two dormitories for Texas Medical Center personnel who need to be in close proximity to their institutions. In a message to the Rice community on April 5, Leebron wrote that the Wiess and Hanszen residential colleges will enable TMC workers to live near their assignments while working the necessary hours during the crisis while offering a better opportunity for rest. The colleges are connected and are almost directly across the street from several TMC institutions.

This was a circumstance in which we thought we had to step in and do what we could to help the people who are really sacrificing to deliver the necessary care to treat the increasing number of victims of COVID-19, Leebron said. We feel very privileged to be here in Houston. We feel privileged to be part of the Texas Medical Center. And even though we dont provide medical care, we do think we have things we can contribute and thats what were doing.

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Mind Over Body: Improving Brain-Computer Interfaces – UPJ Athletics

When people suffer debilitating injuries or illnesses of the nervous system, they sometimes lose the ability to perform tasks normally taken for granted, such as walking, playing music or driving a car. They can imagine doing something, but the injury might block that action from occurring.

Brain-computer interface systems exist that can translate brain signals into a desired action to regain some function, but they can be a burden to use because they dont always operate smoothly and need readjustment to complete even simple tasks.

Researchers at the University of Pittsburgh and Carnegie Mellon University are working on understanding how the brain works when learning tasks with the help of brain-computer interface technology. In a set of papers, the second of which was published today in Nature Biomedical Engineering, the team is moving the needle forward on brain-computer interface technology intended to help improve the lives of amputee patients who use neural prosthetics.

Lets say during your work day, you plan out your evening trip to the grocery store, said Aaron Batista, associate professor of bioengineering in Pitts Swanson School of Engineering. That plan is maintained somewhere in your brain throughout the day, but probably doesnt reach your motor cortex until you actually get to the store. Were developing brain-computer interface technologies that will hopefully one day function at the level of our everyday intentions.

Batista, Pitt postdoctoral research associate Emily Oby and the Carnegie Mellon researchers have collaborated on developing direct pathways from the brain to external devices. They use electrodes smaller than a hair that record neural activity and make it available for control algorithms.

In the team's first study, published last June in the Proceedings of the National Academy of Sciences, the group examined how the brain changes with the learning of new brain-computer interface skills.

When the subjects form a motor intention, it causes patterns of activity across those electrodes, and we render those as movements on a computer screen. The subjects then alter their neural activity patterns in a manner that evokes the movements that they want, said project co-director Steven Chase, a professor of biomedical engineering at the Neuroscience Institute at Carnegie Mellon.

In the new study, the team designed technology whereby the brain-computer interface readjusts itself continually in the background to ensure the system is always in calibration and ready to use.

We change how the neural activity affects the movement of the cursor, and this evokes learning, said Pitts Oby. If we changed that relationship in a certain way, it required that our animal subjects produce new patterns of neural activity to learn to control the movement of the cursor again. Doing so took them weeks of practice, and we could watch how the brain changed as they learned.

In a sense, the algorithm learns how to adjust to the noise and instability that is inherent in neural recording interfaces. The findings suggest that the process for humans to master a new skill involves the generation of new neural activity patterns.The team eventually would like this technology to be used in a clinical setting for stroke rehabilitation.

Such self-recalibration procedures have been a long-sought goal in the field of neural prosthetics, and the method presented in the teams studies is able to recover automatically from instabilities without requiring the user to pause to recalibrate the system by themselves.

Lets say that the instability was so large such that the subject was no longer able to control the brain-computer interface, said Yu. Existing self-recalibration procedures are likely to struggle in that scenario, whereas in our method, weve demonstrated it can in many cases recover from even the most dramatic instabilities.

Both research projects were performed as part of theCenter for the Neural Basis of Cognition. This cross-institutional research and education program leverages the strengths of Pitt in basic and clinical neuroscience and bioengineering with those of Carnegie Mellon in cognitive and computational neuroscience.

Other Carnegie Mellon collaborators on the projects include co-director Byron Yu, professor of electrical and computer engineering and biomedical engineering, and also postdoctoral researchers Alan Degenhart and William Bishop, who led the conduct of the research.

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Will Quantum Computing Really Change The World? Facts And Myths – Analytics India Magazine

In recent years, some big tech companies like IBM, Microsoft, Intel, or Google have been working in relative silence on something that sounds great: quantum computing. The main problem with this is that it is difficult to know what exactly it is and what it can be useful for.

There are some questions that can be easily solved. For example, quantum computing is not going to help you have more FPS on your graphics card at the moment. Nor will it be as easy as changing the CPU of your computer for a quantum to make it hyperfast. Quantum computing is fundamentally different from the computing we are used to, but how?

At the beginning of the 20th century, Planck and Einstein proposed that light is not a continuous wave (like the waves in a pond) but that it is divided into small packages or quanta. This apparently simple idea served to solve a problem called the ultraviolet catastrophe. But over the years other physicists developed it and came to surprising conclusions about the matter, of which we will be interested in two: the superposition of states and entanglement.

To understand why we are interested, lets take a short break and think about how a classic computer works. The basic unit of information is the bit, which can have two possible states (1 or 0) and with which we can perform various logical operations (AND, NOT, OR). Putting together n bits we can represent numbers and operate on those numbers, but with limitations: we can only represent up to 2 different states, and if we want to change x bits we have to perform at least x operations on them: there is no way to magically change them without touching them.

Well, superposition and entanglement allow us to reduce these limitations: with superposition, we can store many more than just 2 ^ n states with n quantum bits (qubits), and entanglement maintains certain relations between qubits in such a way that the operations in one qubit they forcefully affect the rest.

Overlapping, while looking like a blessing at first glance, is also a problem. As Alexander Holevo showed in 1973, even though we have many more states than we can save in n qubits, in practice we can only read 2 ^ n different ones. As we saw in an article in Genbeta about the foundations of quantum computing: a qubit is not only worth 1 or 0 as a normal bit, but it can be 1 in 80% and 0 in 20%. The problem is that when we read it we can only obtain either 1 or 0, and the probabilities that each value had of leaving are lost because when we measured it we modified it.

This discrepancy between the information kept by the qubits and what we can read led Benioff and Feynman to demonstrate that a classical computer would not be able to simulate a quantum system without a disproportionate amount of resources, and to propose models for a quantum computer that did. was able to do that simulation.

Those quantum computers would probably be nothing more than a scientific curiosity without the second concept, entanglement, which allows two quite relevant algorithms to be developed: quantum tempering in 1989 and Shors algorithm in 1994. The first allows finding minimum values of functions, which So said, it does not sound very interesting but it has applications in artificial intelligence and machine learning, as we discussed in another article. For example, if we manage to code the error rate of a neural network as a function to which we can apply quantum quenching, that minimum value will tell us how to configure the neural network to be as efficient as possible.

The second algorithm, the Shor algorithm, helps us to decompose a number into its prime factors much more efficiently than we can achieve on a normal computer. So said, again, it doesnt sound at all interesting. But if I tell you that RSA, one of the most used algorithms to protect and encrypt data on the Internet, is based on the fact that factoring numbers are exponentially slow (adding a bit to the key implies doubling the time it takes to do an attack by force) then the thing changes. A quantum computer with enough qubits would render many encryption systems completely obsolete.

Until now, quantum computing is a field that hasnt been applied much in the real world. To give us an idea, with the twenty qubits of the commercial quantum computer announced by IBM, we could apply Shors factorization algorithm only to numbers less than 1048576, which as you can imagine is not very impressive.

Still, the field has a promising evolution. In 1998 the first ord quantum drive (only two qubits, and needed a nuclear magnetic resonance machine to solve a toy problem (the so-called Deutsch-Jozsa problem). In 2001 Shors algorithm was run for the first time. Only 6 years later, in 2007, D-Wave presented its first computer capable of executing quantum quenching with 16 qubits. This year, the same company announced a 2000 qubit quantum quenching computer. On the other hand, the new IBM computers, although with fewer qubits, they are able to implement generic algorithms and not only that of quantum quenching. In short, it seems that the push is strong and that quantum computing will be increasingly applicable to real problems.

What can those applications be? As we mentioned before, the quantum tempering algorithm is very appropriate for machine learning problems, which makes the computers that implement it extremely useful, although the only thing they can do is run that single algorithm. If systems can be developed that, for example, are capable of transcribing conversations or identifying objects in images and can be translated to train them in quantum computers, the results could be orders of magnitude better than those that already exist. The same algorithm could also be used to find solutions to problems in medicine or chemistry, such as finding the optimal treatment methods for a patient or studying the possible structures of complex molecules.

Generic quantum computers, which have fewer qubits right now, could run more algorithms. For example, they could be used to break much of the crypto used right now as we discussed earlier (which explains why the NSA wanted to have a quantum computer). They would also serve as super-fast search engines if Grovers search algorithm can be implemented, and for physics and chemistry, they can be very useful as efficient simulators of quantum systems.

Unfortunately, algorithms and codes for classic computers couldnt be used on quantum computers and magically get an improvement in speed: you need to develop a quantum algorithm (not a trivial thing) and implement it in order to get that improvement. That, at first, greatly restricts the applications of quantum computers and will be a problem to overcome when those systems are more developed.

However, the main problem facing quantum computing is building computers. Compared to a normal computer, a quantum computer is an extremely complex machine: they operate at a temperature close to absolute zero (-273 C), the qubits support are superconducting and the components to be able to read and manipulate the qubits are not simple either.

What can a non-quantum quantum computer be like? As we have explained before, the two relevant concepts of a quantum computer are superposition and entanglement, and without them, there cannot be the speed improvements that quantum algorithms promise. If computer disturbances modify overlapping qubits and bring them to classical states quickly, or if they break the interweaving between several qubits, what we have is not a quantum computer but only an extremely expensive computer that only serves to run a handful of algorithms. equivalent to a normal computer (and will probably give erroneous results).

Of the two properties, entanglement is the most difficult to maintain and prove to exist. The more qubits there are, the easier it is for one of them to deinterlace (which explains why increasing the number of qubits is not a trivial task). And it is not enough to build the computer and see that correct results come out to say that there are intertwined qubits: looking for evidence of entanglement is a task in itself and in fact, the lack of evidence was one of the main criticisms of D-systems. Wave in its beginnings.

A priori and with the materials that quantum computers are being built with, it does not seem that miniaturization is too feasible. But there is already research on new materials that could be used to create more accessible quantum computers. Who knows if fifty years from now we will be able to buy quantum CPUs to improve the speed of our computers.

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Will Quantum Computing Really Change The World? Facts And Myths - Analytics India Magazine