What is reality? – Big Think

Posted on April 27, 2020 by Danzig

How real are you? What if everything you are, everything you know, all the people in your life as well as all the events were not physically there but just a very elaborate simulation? Philosopher Nick Bostrom famously considered this in his seminal paper Are you living in a computer simulation?, where he proposed that all of our existence may be just a product of very sophisticated computer simulations ran by advanced beings, whose real nature we may never be able to know. Now a new theory comes along that takes it a step further what if there are no advanced beings like that either and everything in "reality" is a self-simulation that generates itself from pure thought?

The physical universe is a "strange loop" says the new paper titled "The Self-Simulation Hypothesis Interpretation of Quantum Mechanics" from the team at the Quantum Gravity Research, a Los Angeles-based theoretical physics institute, founded by the scientist and entrepreneur Klee Irwin. They take Bostrom's simulation hypothesis, which maintains that all of reality is an extremely detailed computer program, and ask - rather than relying on advanced lifeforms to create the amazing technology necessary to compose everything within our world, isn't it more efficient to propose that the universe itself is a "mental self-simulation"? They tie this idea to quantum mechanics, seeing the universe as one of many possible quantum gravity models.

One important aspect that differentiates this view relates to the fact that Bostrom's original hypothesis is materialistic, seeing the universe as inherently physical. To Bostrom, we could simply be part of an ancestor simulation, engineered by posthumans. Even the process of evolution itself could just be a mechanism by which the future beings are testing countless processes, purposefully moving humans through levels of biological and technological growth. In this way they also generate the supposed information or history of our world. Ultimately, we wouldn't know the difference.

But where does the physical reality that would generate the simulations comes from, wonder the researchers? Their hypothesis takes a non-materialistic approach, saying that everything is information expressed as thought. As such, the universe "self-actualizes" itself into existence, relying on underlying algorithms and a rule they call "the principle of efficient language."

Under this proposal, the entire simulation of everything in existence is just one "grand thought". How would the simulation itself be originated? It was always there, say the researchers, explaining the concept of "timeless emergentism". According to this idea, time isn't there at all. Instead, the all-encompassing thought that is our reality offers a nested semblance of a hierarchical order, full of "sub-thoughts" that reach all the way down the rabbit hole towards the base mathematics and fundamental particles. This is also where the rule of efficient language comes in, suggesting that humans themselves are such "emergent sub-thoughts" and they experience and find meaning in the world through other sub-thoughts (called "code-steps or actions") in the most economical fashion.

In correspondence with Big Think, physicist David Chester elaborated: "While many scientists presume materialism to be true, we believe that quantum mechanics may provide hints that our reality is a mental construct. Recent advances in quantum gravity, such as seeing spacetime emergent via a hologram, also is a hint that spacetime is not fundamental. This is also compatible with ancient Hermetic and Indian philosophy. In a sense, the mental construct of reality creates spacetime to efficiently understand itself by creating a network of subconscious entities that can interact and explore the totality of possibilities."

The scientists link their hypothesis to panpsychism, which sees everything as thought or consciousness. The authors think that their "panpsychic self-simulation model" can even explain the origin of an overarching panconsciousness at the foundational level of the simulations, which "self-actualizes itself in a strange loop via self-simulation." This panconsciousness also has free will and its various nested levels essentially have the ability to select what code to actualize, while making syntax choices. The goal of this consciousness? To generate meaning or information.

If all of this is hard to grasp, the authors offer another interesting idea that may link your everyday experience to these philosophical considerations. Think of your dreams as your own personal self-simulations, postulates the team. While they are rather primitive (by super-intelligent future AI standards), dreams tend to provide better resolution than current computer modeling and are a great example of the evolution of the human mind. As the scientists write, "What is most remarkable is the ultra-high-fidelity resolution of these mind-based simulations and the accuracy of the physics therein." They point especially to lucid dreams, where the dreamer is aware of being in a dream, as instances of very accurate simulations created by your mind that may be impossible to distinguish from any other reality. To that end, now that you're sitting here reading this article, how do you really know you're not in a dream? The experience seems very high in resolution but so do some dreams. It's not too much of a reach to imagine that an extremely powerful computer that we may be able to make in not-too-distant future could duplicate this level of detail.

The team also proposes that in the coming years we will be able to create designer consciousnesses for ourselves as advancements in gene editing could allow us to make our own mind-simulations much more powerful. We may also see minds emerging that do not require matter at all.

While some of these ideas are certainly controversial in the mainstream science circles, Klee and his team respond that "We must critically think about consciousness and certain aspects of philosophy that are uncomfortable subjects to some scientists."

Want to know more? You can read the full paper online in the journal Entropy.

More on the hypothesis and the backstory of the Quantum Gravity Research institute

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Faith and Values: What the butterfly effect can teach us about the coronavirus and spirituality – The Spokesman-Review

Posted on April 27, 2020 by Danzig

Our church family celebrated Easter via Zoom two weeks ago. Our pastor led worship from her living room.

Behind her left shoulder, I saw a paper butterfly in full flap. The butterfly has become a fashionable Easter symbol for many people, pointing to the dramatic body change from caterpillar to flying beauty.

But recently, Ive seen how the butterfly effect impacts us both spiritually and scientifically.

Id known something of the meteorological reference to the butterfly effect for years. It was most famously mentioned in 1972 by meteorologist Edward Lorenz in a presentation to a science convention.

He asked this question: Does the flap of a butterflys wings in Brazil set off a tornado in Texas? Scientists are still seeking the answer.

What Lorenz was not discovering scientific certainty, but scientific unpredictability. His research underlies what became chaos theory in quantum physics.

His inquiry began as he was working on a computer calculation for a weather prediction. The tiny number he first used was 0.506127. Then he recalculated by rounding that number to 0.506. And he got a very different weather prediction.

Suddenly the reality of randomness became real. What if our scientific calculations are not as determined as we want them to be? What if unpredictability, randomness, is a bigger player in the cosmic, scientific scheme of things?

And here is our transition, informed by science but experienced in the spiritual dimension of our lives: What if we cannot predict, let alone control, the spirit of God any more than meteorology can control the weather on, say, Easter Sunday? Perish the thought.

The implications are not only cosmic, friends. They filter down to the very ways we do church, the way we order our lives. Whether we use certain religious language and structures, or whether we free-wheel our approach to living, there are simply many things we dont/cant control.

That doesnt mean there is no order, no predictability, or no ultimate control in daily living. Even in the midst of the viral pandemic that were all impacted by, there may be order, predictability and control we cant begin to comprehend.

Yet we do our best to control it sometimes smartly, sometimes foolishly. Have you considered how infinitesimal the actual coronavirus actually is? But what a huge difference it has made in lives around the world.

As you consider that abstract thought, also consider this concrete question: What small gesture(s) have you made recently that brought a sliver of hope, maybe gratitude, to another person? What small gesture did you receive that brought that hope or gratitude to you? Small gestures can lead to big differences.

Yet we may never see those consequences. Jesus Matthew 25:40 affirmation, If you do it to the least of these, youve done it to me, is a pointed reminder that Jesus knew small changes can lead to big differences sometimes for the receiver, sometimes for the giver.

Since it was published in 1969, anthropologist Loren Eiseleys Star Thrower has taken on a tender and powerful life of its own.

It tells of a man who sees a boy on the seashore, throwing starfish back into the ocean. The man asks the boy why hes doing such an impossible job. What difference does it make?

The boy simply answers, It makes a difference to this starfish. Indeed. Check out the 3-minute YouTube dramatization of this story.

On a scientific level or on a personal level of spiritual awareness, the butterfly effect creates unpredictable, mysterious magic. Your small change can make a big difference elsewhere.

You may never see it. Do it anyway!

The Rev. Paul Graves, a Sandpoint resident and retired United Methodist minister, can be contacted at welhouse@nctv.com.

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Faith and Values: What the butterfly effect can teach us about the coronavirus and spirituality - The Spokesman-Review

Wiring the Quantum Computer of the Future: Researchers from Japan and Australia propose a novel 2D design – QS WOW News

Posted on April 27, 2020 by Danzig

The basic units of a quantum computer can be rearranged in 2D to solve typical design and operation challenges. Efficient quantum computing is expected to enable advancements that are impossible with classical computers. A group of scientists from Tokyo University of Science, Japan, RIKEN Centre for Emergent Matter Science, Japan, and the University of Technology, Sydney have collaborated and proposed a novel two-dimensional design that can be constructed using existing integrated circuit technology. This design solves typical problems facing the current three-dimensional packaging for scaled-up quantum computers, bringing the future one step closer.

Quantum computing is increasingly becoming the focus of scientists in fields such as physics and chemistry, and industrialists in the pharmaceutical, airplane, and automobile industries. Globally, research labs at companies like Google and IBM are spending extensive resources on improving quantum computers, and with good reason. Quantum computers use the fundamentals of quantum mechanics to process significantly greater amounts of information much faster than classical computers. It is expected that when the error-corrected and fault-tolerant quantum computation is achieved, scientific and technological advancement will occur at an unprecedented scale.

But, building quantum computers for large-scale computation is proving to be a challenge in terms of their architecture. The basic units of a quantum computer are the quantum bits or qubits. These are typically atoms, ions, photons, subatomic particles such as electrons, or even larger elements that simultaneously exist in multiple states, making it possible to obtain several potential outcomes rapidly for large volumes of data. The theoretical requirement for quantum computers is that these are arranged in two-dimensional (2D) arrays, where each qubit is both coupled with its nearest neighbor and connected to the necessary external control lines and devices. When the number of qubits in an array is increased, it becomes difficult to reach qubits in the interior of the array from the edge. The need to solve this problem has so far resulted in complex three-dimensional (3D) wiring systems across multiple planes in which many wires intersect, making their construction a significant engineering challenge. https://youtu.be/14a__swsYSU

The team of scientists led by Prof Jaw-Shen Tsai has proposed a unique solution to this qubit accessibility problem by modifying the architecture of the qubit array. Here, we solve this problem and present a modified superconducting micro-architecture that does not require any 3D external line technology and reverts to a completely planar design, they say. This study has been published in the New Journal of Physics.

The scientists began with a qubit square lattice array and stretched out each column in the 2D plane. They then folded each successive column on top of each other, forming a dual one-dimensional array called a bi-linear array. This put all qubits on the edge and simplified the arrangement of the required wiring system. The system is also completely in 2D. In this new architecture, some of the inter-qubit wiringeach qubit is also connected to all adjacent qubits in an arraydoes overlap, but because these are the only overlaps in the wiring, simple local 3D systems such as airbridges at the point of overlap are enough and the system overall remains in 2D. As you can imagine, this simplifies its construction considerably.

The scientists evaluated the feasibility of this new arrangement through numerical and experimental evaluation in which they tested how much of a signal was retained before and after it passed through an airbridge. The results of both evaluations showed that it is possible to build and run this system using existing technology and without any 3D arrangement.

The scientists experiments also showed them that their architecture solves several problems that plague the 3D structures: they are difficult to construct, there is crosstalk or signal interference between waves transmitted across two wires, and the fragile quantum states of the qubits can degrade. The novel pseudo-2D design reduces the number of times wires cross each other, thereby reducing the crosstalk and consequently increasing the efficiency of the system.

At a time when large labs worldwide are attempting to find ways to build large-scale fault-tolerant quantum computers, the findings of this exciting new study indicate that such computers can be built using existing 2D integrated circuit technology. The quantum computer is an information device expected to far exceed the capabilities of modern computers, Prof Tsai states. The research journey in this direction has only begun with this study, and Prof Tsai concludes by saying, We are planning to construct a small-scale circuit to further examine and explore the possibility.

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Wiring the Quantum Computer of the Future: Researchers from Japan and Australia propose a novel 2D design - QS WOW News

New way of developing topological superconductivity discovered – Chemie.de

Posted on April 27, 2020 by Danzig

Hybrid material nanowires with pencil-like cross section (A) at low temperatures and finite magnetic field display zero-energy peaks (B) consistent with topological superconductivity as verified by numerical simulations (C).

A pencil shaped semiconductor, measuring only a few hundred nanometers in diameter, is what researches from the Center for Quantum Devices, Niels Bohr Institute, at University of Copenhagen, in collaboration with Microsoft Quantum researchers, have used to uncover a new route to topological superconductivity and Majorana zero modes in a study recently published in Science.

The new route that the researchers discovered uses the phase winding around the circumference of a cylindrical superconductor surrounding a semiconductor, an approach they call "a conceptual breakthrough".

"The result may provide a useful route toward the use of Majorana zero modes as a basis of protected qubits for quantum information. We do not know if these wires themselves will be useful, or if just the ideas will be useful," says Charles Marcus, Villum Kann Rasmussen Professor at the Niels Bohr Institute and Scientific Director of Microsoft Quantum Lab in Copenhagen.

"What we have found appears to be a much easier way of creating Majorana zero modes, where you can switch them on and off, and that can make a huge difference"; says postdoctoral research fellow, Saulius Vaitieknas, who was the lead experimentalist on the study.

The new research merges two already known ideas used in the world of quantum mechanics: Vortex-based topological superconductors and the one-dimensional topological superconductivity in nanowires.

"The significance of this result is that it unifies different approaches to understanding and creating topological superconductivity and Majorana zero modes", says professor Karsten Flensberg, Director of the Center for Quantum Devices.

Looking back in time, the findings can be described as an extension of a 50-year old piece of physics known as the Little-Parks effect. In the Little-Parks effect, a superconductor in the shape of a cylindrical shell adjusts to an external magnetic field, threading the cylinder by jumping to a "vortex state" where the quantum wavefunction around the cylinder carries a twist of its phase.

Charles M. Marcus, Saulius Vaitieknas, and Karsten Flensberg from the Niels Bohr Institute at the Microsoft Quantum Lab in Copenhagen.

What was needed was a special type of material that combined semiconductor nanowires and superconducting aluminum. Those materials were developed in the Center for Quantum Devices in the few years. The particular wires for this study were special in having the superconducting shell fully surround the semiconductor. These were grown by professor Peter Krogstrup, also at the Center for Quantum Devices and Scientific Director of the Microsoft Quantum Materials Lab in Lyngby.

The research is the result of the same basic scientific wondering that through history has led to many great discoveries.

"Our motivation to look at this in the first place was that it seemed interesting and we didn't know what would happen", says Charles Marcus about the experimental discovery, which was confirmed theoretically in the same publication. Nonetheless, the idea may indicate a path forward for quantum computing.

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100 years later, where is the physics department now? – The Daily Evergreen

Posted on April 27, 2020 by Danzig

Researchers talk about quantum physics, renewable energy, morphing materials into different shapes, interior of stars

BENJAMIN MICHAELIS

The WSU physics and astronomy department is located in Webster Hall. Brian Saam, physics and astronomy department chair, said the department was created by Paul Anderson, William Band and George Duvall.

Since the WSU physics and astronomy departments founding 100 years ago, researchers have made developments that make the program known worldwide.

Brian Saam, physics and astronomy department chair, said the history of the department started with three men that helped lift the department off its feet.

Saam said these three men were Paul Anderson, William Band and George Duvall. Anderson helped develop ultra-high vacuum technology, Band was an influential theoretical physicist and Duvall helped build the shock physics program to be one of the leading programs in the world.

Along with being chair of the department, Saam researches atomic physics. He works with lasers, as well as leads a research group with graduate students and post-doctoral students.

The WSU physics and astronomy department is one of the smallest in the Pac-12 conference, Saam said. Other universities in the conference are double in size.

We punch above our weight, Saam said.

To celebrate 100 years, the department held a colloquium guest speaker series. The series started in January.

Some of the past speakers included research engineer Sarah Kaiser, who spoke about The science isnt magic, but we are, and physicist Marc Weber, who spoke about Antimatter in our daily world.

Peter Engels, an experimental atomic physicist, works with samples of atoms that assemble at low temperatures which are close to absolute zero, Saam said.

Engels work tells scientists a lot about the quantum physics world, he said.

This type of physics has a variety of applications, such as renewable energy technology, electronics and understanding the interior of stars, Saam said.

This type of physics tries to explain what happens when a material is compressed at a high level. Some objects vibrate or liquify when they are squeezed. The research is applied to when stars explode.

Researchers in this department set up cannons to blast materials into each other to simulate these conditions of extreme pressures and extreme temperatures, he said.

It has applications for fundamental science, Saam said. It got its start here at WSU. This is the home of that whole area of exploration in physics.

Mark Kuzyk, WSU regents professor, said he came to WSU in the 1990s.

His research focuses on materials that change shape when light hits it.

The most exciting application for his research is Kuzyk can morph material into whatever shape he wants with the light beams, he said.

You say paper and it turns into paper or you say iPhone and it turns into an iPhone, he said. Thats really far off, but thats kind of the general idea.

Kuzyk started this research in the 90s and WSU researchers were the only ones in the field, he said. The type of research just recently started to become popular in the science realm.

WSU received grants to study this area in collaboration with the University of Massachusetts, Kent State University and California Institute of Technology. The project will end this summer but they are looking to the future to further their research.

The material samples, which are plastic, sit in a chamber. The contraption is computer controlled. Then lasers direct the light to the sample.

If the length of the material changes microscopically, then it will not work, Kuzyk said.

Saam said when he came to the department he noticed the faculty is almost entirely made up of men. One of his goals this year is to hire more women.

One of the things wed like to do is as we move forward with new [faculty searches] is wed like to address gender inequity and have better representation from women and other underrepresented groups, Saam said.

Kuzyk said one of the more notable moments he has had at WSU was working with a female doctorate student from Greece during the 90s.

Kuzyk left for a conference for two weeks and his student was given work to complete by the time he got back.

She tried and tried, but it was not working. The student was about to quit and thought about going home, so she decided to call her mother.

Her mother said to her, Good, because no women should be doing science, Kuzyk said.

Her mothers words gave the student more motivation to keep working on the problems and she finished them two days before he returned to Pullman, Kuzyk said.

Three years after graduating, the student went to work with IBM and other research labs, he said. The person she worked for at IBM ended up winning a Nobel Peace Prize.

Now she is the senior director of a pharmaceutical company.

When I was a grad student, there might have been one or two [women] in the department, he said. Whereas now weve had certain years where weve had lots of women in an incoming class.

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100 years later, where is the physics department now? - The Daily Evergreen

Theoretical Predictions of High-Energy-Density Physics Shed Light on the Universe – AZoQuantum

Posted on April 27, 2020 by Danzig

Written by AZoQuantumApr 27 2020

Extreme pressures and temperatures cause both the atoms and molecules to behave in a very different manner. While such extreme matter is present abundantly in the universe, particularly in the deep interiors of stars and planets, they do not occur naturally on the planet earth.

By interpreting the way atoms respond under extreme pressure conditionsa field called high-energy-density physics (HEDP)researchers can gain useful insights into the fields of astrophysics, planetary science, national security, and fusion energy.

The field of HED science poses an important question, that is, how would matter under extreme pressure conditions would absorb or produce radiation in ways that are completely different from peoples conventional interpretation.

In a study published in the Nature Communications journal, researchers have successfully applied the theory and calculations to estimate the presence of a couple of novel phenomenathat is, the breakdown of dipole selection rule and the interspecies radiative transition (IRT)in the transport of radiation in molecules and atoms placed under HED conditions.

This study was carried out by Suxing Hu, a distinguished researcher and also a group leader of the HEDP Theory Group at the Laboratory for Laser Energetics (LLE) of the University of Rochester, along with collaborators from the LLE and France. The study improves ones interpretation of HED science and may lead to additional data about the evolution of astrophysical objects, including stars, in the universe.

Radiative transition can be described as a physical phenomenon that occurs within the molecules and atoms, wherein their electron or electrons can jump from different levels of energy by either absorbing or emitting (radiating) a single photon.

The researchers discovered that for a matter that is involved in peoples day-to-day lives, such radiative transitions largely occur inside each individual molecule or atom; the single electron jumps between energy levels that belong to one molecule or atom, and the jumping process does not often take place between varying molecules and atoms.

According to the prediction made by Hu and his collaborators, when both molecules and atoms are placed under HED conditions and packed very tightly such that they become quite close to one another, the result is radiative transitions that involve adjacent molecules and atoms.

Namely, the electrons can now jump from one atoms energy levels to those of other neighboring atoms.

Suxing Hu, Distinguished Scientist and Group Leader of HEDP Theory Group, Laboratory for Laser Energetics, University of Rochester

Within a single atom, electrons exhibit particular symmetries. For instance, s-wave electrons are invariably spherically symmetric, which implies that they resemble a ball, with the nucleus situated in the center of the atom; on the other hand, p-wave electrons, resemble the dumbbells. More intricate shapes are exhibited by D-waves and other types of electron states.

Generally, radiative transitions will take place when the electron jumping follows the dipole selection rule. The jumping electron in this so-called dipole selection rule alters its shape from s-wave to p-wave, from p-wave to d-wave, and so on.

Under standard, non-extreme conditions, one hardly sees electrons jumping among the same shapes, from s-wave to s-wave and from p-wave to p-wave, by emitting or absorbing photons, added Hu.

But as Hu and his collaborators discovered that the dipole selection rule is usually broken down when materials are packed very tightly into the unusual HED state.

Under such extreme conditions found in the center of stars and classes of laboratory fusion experiments, non-dipole x-ray emissions and absorptions can occur, which was never imagined before.

Suxing Hu, Distinguished Scientist and Group Leader of HEDP Theory Group, Laboratory for Laser Energetics, University of Rochester

To perform their calculations, the scientists utilized supercomputers at the University of Rochesters Center for Integrated Research Computing (CIRC) and also at the LLE.

Thanks to the tremendous advances in high-energy laser and pulsed-power technologies, bringing stars to the earth has become reality for the past decade or two.

Suxing Hu, Distinguished Scientist and Group Leader of HEDP Theory Group, Laboratory for Laser Energetics, University of Rochester

To conduct their research, Hu and his collaborators used the density-functional theory (DFT) calculation that provides a quantum mechanical depiction of the bonds that exist between molecules and atoms in intricate systems.

Initially elucidated in the 1960s, the DFT technique was the subject of the Nobel Prize in Chemistry awarded in 1998, and since then, DFT calculations have been incrementally improved. One such enhancement to facilitate DFT calculations to involve the main electrons was made by Valentin Karasev, the studys co-author and a researcher at the LLE.

The outcomes suggest the appearance of new absorption and emission lines in the X-ray spectra of these extreme matter systems. These systems represent the earlier unrecognized channels of IRT and the disintegration of the dipole selection rule.

Hu, and Philip Nilson, the studys co-author and a senior researcher at the LLE, have now planned to perform more experiments in the future in which these latest theoretical predictions will be tested at LLEs OMEGA laser facility. This facility allows users to produce unusual HED conditions in nanosecond timescales, thus enabling researchers to analyze the matters exclusive behaviors at high conditions.

If proved to be true by experiments, these new discoveries will profoundly change how radiation transport is currently treated in exotic HED materials. These DFT-predicted new emission and absorption channels have never been considered so far in textbooks, Hu concluded.

The study is based on work that was financially supported by the New York State Energy Research and Development Authority and the United States Department of Energy (DOE) National Nuclear Security Administration. The National Science Foundation partly supported the research.

Source: https://www.rochester.edu/

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Theoretical Predictions of High-Energy-Density Physics Shed Light on the Universe - AZoQuantum

CRISPR combines with stem cell therapy to reverse diabetes in mice – New Atlas

Posted on April 27, 2020 by Danzig

For a few years now, scientists at Washington University have been working on techniques to turn stem cells into pancreatic beta cells as a way of addressing insulin shortages in diabetics. After some promising recent strides, the team is now reporting another exciting breakthrough, combining this technique with the CRISPR gene-editing tool to reverse the disease in mice.

The pancreas contains what are known as beta cells, which secrete insulin as a way of tempering spikes in blood-sugar levels. But in those with diabetes, these beta cells either die off or dont function as they should, which means sufferers have to rely on diet and or regular insulin injections to manage their blood-sugar levels instead.

One of the ways scientists are working to replenish these stocks of pancreatic beta cells is by making them out of human stem cells, which are versatile, blank slate-like cells that can mature into almost any type of cell in the human body. The Washington University team has operated at the vanguard of this technology with a number of key breakthroughs, most recently with a cell implantation technique that functionally cured mice with diabetes.

The researchers are continuing to press ahead in search of new and improved methods, and this led them to the CRISPR gene-editing system, which itself has shown real promise as a tool to treat diabetes. The hope was that CRISPR could be used to correct genetic defects leading to diabetes, combining with the stem cell therapy to produce even more effective results.

As a proof of concept, the scientists took skin cells from a patient with a rare genetic type of diabetes called Wolfram syndrome, which develops during childhood and typically involves multiple insulin injections each day. These skin cells were converted into induced pluripotent stem cells, which were in turn converted into insulin-secreting beta cells. But as an additional step, CRISPR was used to correct a genetic mutation that causes Wolfram syndrome.

These edited beta cells were then pitted against non-edited beta cells from the same batch in test tube experiments and in mice with a severe type of diabetes. The edited cells proved more efficient at secreting insulin and when implanted under the skin in mice, reportedly caused the diabetes to quickly disappear. The rodents that received the unedited beta cells remained diabetic.

This is the first time CRISPR has been used to fix a patients diabetes-causing genetic defect and successfully reverse diabetes, said co-senior investigator Jeffrey R. Millman. For this study, we used cells from a patient with Wolfram syndrome because, conceptually, we knew it would be easier to correct a defect caused by a single gene. But we see this as a stepping stone toward applying gene therapy to a broader population of patients with diabetes.

The researchers are now continuing to work on improving the beta cell production technique, which in the future could involve cells taken form the blood or even urine, rather than the skin. They believe that further down the track this therapy could prove useful in treating both type 1 and type 2 diabetes, by correcting mutations that arise from genetic and environmental factors, and possibly be used to treat other conditions, as well.

We basically were able to use these cells to cure the problem, making normal beta cells by correcting this mutation, said co-senior investigator Fumihiko Urano. Its a proof of concept demonstrating that correcting gene defects that cause or contribute to diabetes in this case, in the Wolfram syndrome gene we can make beta cells that more effectively control blood sugar. Its also possible that by correcting the genetic defects in these cells, we may correct other problems Wolfram syndrome patients experience, such as visual impairment and neurodegeneration.

The research was published in the journal Science Translational Medicine.

Source: Washington University

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CRISPR combines with stem cell therapy to reverse diabetes in mice - New Atlas

‘Stem cell therapy more effective on Covid-19’ – Korea Biomedical Review – Korea Biomedical Review

Posted on April 27, 2020 by Danzig

I dont know why people pay attention only to vaccines and treatments against the new coronavirus. Stem cell therapies are more useful to treat Covid-19.

So claimed Lee Hee-young, president of the Korean Association of Stemcell Therapy, at a news conference in Seoul, Monday. He called for active use of stem cell therapies to treat Covid-19 patients.

Several studies have proved the effects of autologous stem cells in treating acute respiratory distress syndrome (ARDS), which is the leading cause of death in Covid-19 patients, Lee said. The concept of stem cell therapy is the same as that of blood transfusion or bone marrow transplantation. Decades of cell therapies have proved that stem cell therapy is safe.

While the development of a treatment or a vaccine against Covid-19 takes a long time and it may not be able to treat patients immediately because of virus mutation possibilities, stem cell therapies can restore damaged lungs directly, Lee claimed.

It is more important to restore damaged lungs than to fight the virus. Stem cell therapy restores the lungs, giving patients time to beat the virus, he went on to say. However, people are paying attention to vaccine or treatment candidates only. This is why I am holding a news conference.

Lee pointed out that the local environment makes it difficult to use stem cell therapies. Thus, the government should ease regulations on the management and use of cell culture facilities so that doctors can perform stem cell therapies with simple cell culture, he said.

As long as physicians have a positive pressure facility and a culture kit, they can separate and culture cells with simple training, he said. If the authorities allow doctors to perform stem cell therapies with a disposable mobile culture autonomously, the cost of stem cell therapies will go down significantly.

Lee added that he asked related officials to include such rules in the Act on Safety and Support for Advanced Regenerative Medicine and Advanced Biopharmaceuticals, which is to take effect in the second half of the year.

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'Stem cell therapy more effective on Covid-19' - Korea Biomedical Review - Korea Biomedical Review

Stem Cell Therapy Shows 83% Survival in COVID-19 Patients Dependent on Ventilator – HospiMedica

Posted on April 27, 2020 by Danzig

Ventilator-dependent COVID-19 patients with moderate/severe acute respiratory distress syndrome (ARDS) who were treated with intravenous infusions of an allogeneic mesenchymal stem cell product candidate had a survival rate of 83%.

The allogeneic mesenchymal stem cell product candidate remestemcel-L from Mesoblast Limited (Melbourne, Australia) was administered within the first five days under emergency compassionate use at New York Citys Mt Sinai hospital during the period March-April 2020. Patients received a variety of experimental agents prior to remestemcel-L. All patients were treated under an emergency Investigational New Drug (IND) application or expanded access protocol at Mt Sinai hospital. 75% of the patents successfully came off ventilator support within a median of 10 days, in contrast to only 9% of ventilator-dependent COVID-19 patients being able to come off ventilators with standard of care treatment and only 12% survival in ventilator-dependent COVID-19 patients at two major referral hospital networks in New York during the same time period. These poor outcomes are consistent with earlier published data from China where mortality rates of over 80% were reported in patients with COVID-19 and moderate/severe ARDS.

The remarkable clinical outcomes in these critically ill patients continue to underscore the potential benefits of remestemcel-L as an anti-inflammatory agent in cytokine release syndromes associated with high mortality, including acute graft versus host disease and COVID-19 ARDS, said Mesoblast Chief Executive Dr. Silviu Itescu. We intend to rapidly complete the randomized, placebo-controlled Phase 2/3 trial in COVID-19 ARDS patients to rigorously confirm that remestemcel-L improves survival in these critically ill patients.

There is a significant need to improve the dismal survival outcomes in COVID-19 patients who progress to ARDS and require ventilators, said Mesoblast Chief Medical Officer Dr Fred Grossman. We have implemented robust statistical analyses in our Phase 2/3 trial as recommended by the US Food and Drug Administration (FDA) in order to maximize our ability to evaluate whether remestemcel-L provides a survival benefit in moderate/severe COVID-19 ARDS.

Coronavirus Q&A: Dr. Camillo Ricordi Gives Update On Trials Of Stem Cell Treatment For Most Severe COVID-19 Cases – CBS Miami

Posted on April 27, 2020 by Danzig

MIAMI (CBSMiami) A team of doctors at the University of Miami is working on what could be groundbreaking therapy for treating some COVID-19 patients.

With a focus on those suffering with severe lung inflammation, theyre using the umbilical system cells to treat patients.

For an update on how its progressing, Dr. Camillo Ricordi, a University of Miami professor and stem cell therapy researcher, joined Eliott Rodriguez and Rudabeh Shahbazi via Skype.

Q: This therapy is building off a 10-patient study in China and the results of that study are limited. So what information gave you hope that this would work on a broad scale?

A: Well, the information from this initial study have been incredibly encouraging. The editor in chief of the journal that did editorial on the paper presented commented as extraordinary results, but that need to be validated by law by lots of clinical trials. So were happy that FDA approved us to do such clinical trial at the University of Miami. And the nice thing is that well have the results in a very short time because these cells is like injecting anatomy of cells, 200 million cells, into those that will be fighting the complication of the infection and will know within weeks the there is a positive effect.

Q: How many patients are in the trial? When did you start? Have you seen any results so far?

A: We did. We have 24 patients in this initial trials. We didnt start the first patient, there have been only patients that are on compassionate release so far. And the initial results are coming from China and Israel. But we are ready to go. We have the terms the six doses already ready to be delivered and other 25 doses are ready to follow. So we have over as far as cell supply for the entire clinical trial, and we hope to have results very soon.

Q: So for the layman like us, can you explain how, why the stem cells infused in a vein end up in a lung?

A: Yeah, actually, this is a nice feature because when we do these trials, I directed Diabetes Research Institute at the University of Miami, so, traditionally, we did this trial for type 1 diabetes or for kidney disease. But in this case, when you inject the cells IV, intravenously, the first filter that is the lungs. So naturally the cells are trapped by the lungs as much as 95%. So in the case of targeting the pancreas or the kidney, you have to do an interventional radiology procedure to put a catheter in there that goes to these organs. But when you target the lung, this is a natural way of delivery and these cells form naturally to the lung. In addition, the cells sense inflammation and tissue injury, and hone, they go targeting specifically the site of tissue injury and inflammation. So in this case is even more relevant that in a simple intravenous, like a blood transfusion, will exactly target the lung, that is the organ that we want to treat

Q: How long do you expect to have to wait before you know if this was working?

A: Well, we know from the radiologic examination of the lungs from the studies in China, for example, that within days a resolution of the lung pathology.

Q: What is the typical recovery rate for COVID patients who have been put on a ventilator and is that meant to treat patients before they get to that critical stage?

A: Well, the typical recovery rate that we expect with this treatment is within a week we should know. So this is not a trial that we are required, like months or years of follow up to see if there is a beneficial effect or not. We are confident that within days or a week you will know if this is working or not as soon as we start.

Q: Is this is therapy meant to complement other forms of therapy?

A: I think it will definitely be used as a combination therapy. We dont exclude any other therapy as part of the combination therapy. With another agent that may help fight this is immune reaction, this pro-inflammatory reaction and also the problem that you see in micro-thromboembolism and the coagulation problem that you see in these patients. So I think is in a way is a unique therapy because its not just for COVID-19, but its for any virus targeting the lung with this massive reaction. So it will be something that we are planning in the future to create the repository for rapid intervention and integrated response to any pandemic or a situation in which you have an emergency that you need to treat an injury to the lung of such dimension. But in the meantime, when there is not a pandemic situation, you can use these cells. We have trials ongoing that has been authorized by the FDA for type 1 diabetes, Alzheimer, for kidney disease. So its a cell type that can be used in many other situations to start normal organ function, not just COVID-19.

Q: If this succeeds, how big of a deal is it?

A: If this succeeds, it will be a way to treat the severe cases of COVID-19 while we wait for a vaccine. But also to have a repository of cells that will be able to treat any other possible pandemic or epidemic where the lung will be a target of the viral attack. In this case, you have an army of cells that are ready to be used and fight this viral infection and all the consequences that can induce in the lungs.

RELATED:Current Curfews In South FloridaDrive-Through Testing LocationsTrack The Spread Of The Coronavirus In Real TimeHow To Make Your Own Face Mask

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Coronavirus Q&A: Dr. Camillo Ricordi Gives Update On Trials Of Stem Cell Treatment For Most Severe COVID-19 Cases - CBS Miami

Impact of COVID-19 on Stem Cell Therapy Market Investment Opportunities And Forecast 2020-2027 | By Top Key Players Magellan, Medipost Co., Ltd,…

Posted on April 27, 2020 by Danzig

The Stem Cell Therapy Market Has Witnessed Continuous Growth In The Past Few Years And Is Projected To Grow Even Further During The Forecast Period (2020-2027). The Assessment Provides A 360 View And Insights, Outlining The Key Outcomes Of The Industry. These Insights Help The Business Decision-makers To Formulate Better Business Plans And Make Informed Decisions For Improved Profitability. In Addition, The Study Helps Venture Or Private Players In Understanding The Companies More Precisely To Make Better-informed Decisions. Some Of The Prominent Key Players Covered In The Stem Cell Therapy Market Are Magellan, Medipost Co., Ltd, Osiris Therapeutics, Inc., Kolon TissueGene, Inc., JCR Pharmaceuticals Co., Ltd., Anterogen Co. Ltd., Pharmicell Co., Inc., and Stemedica Cell Technologies, Inc.

Whats Keeping Magellan, Medipost Co., Ltd, Osiris Therapeutics, Inc., Kolon TissueGene, Inc., JCR Pharmaceuticals Co., Ltd., Anterogen Co. Ltd., Pharmicell Co., Inc., and Stemedica Cell Technologies, Inc. Ahead In The Market? Benchmark Yourself With Strategic Steps And Conclusions Recently Published By Coherent Market Insights

Type Segmentation:

By Cell Source:Adult Stem CellsInduced Pluripotent Stem CellsEmbryonic Stem CellsOthersGlobal Stem Cell Therapy Market, By Application:Musculoskeletal DisordersWounds and InjuriesCancerAutoimmune disordersOthers

Consumer Traits (If Applicable)

The Stem Cell Therapy Market Study Covers Current Status, % Share, Future Patterns, Development Rate, Swot Examination, Sales Channels, To Anticipate Growth Scenarios For Years 2020-2027. It Aims To Recommend Analysis Of The Market With Regards To Growth Trends, Prospects, And Players Contribution To Market Development. The Report Size Market By 5 Major Regions, Known As, North America, Europe, Asia Pacific (Includes Asia & Oceania Separately), Middle East And Africa (Mea), And Latin America.

The Stem Cell Therapy Market Factors Described In This Report Are:-key Strategic Developments In Stem Cell Therapy Market: The Research Includes The Key Strategic Activities Such As R&d Plans, M&a Completed, Agreements, New Launches, Collaborations, Partnerships & (Jv) Joint Ventures, And Regional Growth Of The Key Competitors Operating In The Market At A Global And Regional Scale.

Key Market Features In Stem Cell Therapy Market: The Report Highlights Stem Cell Therapy Market Features, Including Revenue, Weighted Average Regional Price, Capacity Utilization Rate, Production Rate, Gross Margins, Consumption, Import & Export, Supply & Demand, Cost Bench-marking, Market Share, Cagr, And Gross Margin.

Analytical Market Highlights & Approach The Stem Cell Therapy Market Report Provides The Rigorously Studied And Evaluated Data Of The Top Industry Players And Their Scope In The Market By Means Of Several Analytical Tools. The Analytical Tools Such As Porters Five Forces Analysis, Feasibility Study, Swot Analysis, And Roi Analysis Have Been Practiced Reviewing The Growth Of The Key Players Operating In The Market.

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Table Of Contents:

Stem Cell Therapy Market Study Coverage: It Includes Major Manufacturers, Emerging Players Growth Story, Major Business Segments Of Stem Cell Therapy Market, Years Considered, And Research Objectives. Additionally, Segmentation On The Basis Of The Type Of Product, Application, And Technology.

Stem Cell Therapy Market Executive Summary: It Gives A Summary Of Overall Studies, Growth Rate, Available Market, Competitive Landscape, Market Drivers, Trends, And Issues, And Macroscopic Indicators.Stem Cell Therapy Market Production By Region Stem Cell Therapy Market Profile Of Manufacturers-players Are Studied On The Basis Of Swot, Their Products, Production, Value, Financials, And Other Vital Factors.

Key Points Covered In Stem Cell Therapy Market Report: Stem Cell Therapy Overview, Definition And Classification Market Drivers And Barriers

Stem Cell Therapy Market Competition By Manufacturers

Stem Cell Therapy Capacity, Production, Revenue (Value) By Region (2019-2027)

Stem Cell Therapy Supply (Production), Consumption, Export, Import By Region (2019-2027)

Stem Cell Therapy Production, Revenue (Value), Price Trend By Type {strip Sensors, Invasive Sensors, Ingestible Sensors, Implantable Sensors, Wearable Sensors}

Stem Cell Therapy Market Analysis By Application {hospitals, Ambulatory Surgical Centers, Diagnostic Centers}

Stem Cell Therapy Manufacturers Profiles/analysis Stem Cell Therapy Manufacturing Cost Analysis, Industrial/supply Chain Analysis, Sourcing Strategy And Downstream Buyers, Marketing Strategy By Key Manufacturers/players, Connected Distributors/traders Standardization, Regulatory And Collaborative Initiatives, Industry Road Map And Value Chain Market Effect Factors Analysis.

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Impact of COVID-19 on Stem Cell Therapy Market Investment Opportunities And Forecast 2020-2027 | By Top Key Players Magellan, Medipost Co., Ltd,...

World coronavirus Dispatch: Animal Stem Cell Therapy Market Forecasted To Surpass The Value Of US$ XX Mn/Bn By 2036 2017 2025 – Latest Herald

Posted on April 27, 2020 by Danzig

Given the debilitating impact of COVID-19 (Coronavirus) on the Animal Stem Cell Therapy market, companies are vying opportunities to stay afloat in the market landscape. Gain access to our latest research analysis on COVID-19 associated with the Animal Stem Cell Therapy market and understand how market players are adopting new strategies to mitigate the impact of the pandemic.

Analysis of the Global Animal Stem Cell Therapy Market

Persistence Market Research (PMR) recently published a market study which provides a detailed understanding of the various factors that are likely to influence the Animal Stem Cell Therapy market in the forecast period (20XX-20XX). The study demonstrates the historical and current market trends to predict the roadmap of the Animal Stem Cell Therapy market in the coming years. Further, the growth opportunities, capacity additions, and major limitations faced by market players in the Animal Stem Cell Therapy market are discussed.

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Regional Overview

Our team of analysts at PMR, trace the major developments within the Animal Stem Cell Therapy landscape in various geographies. The market share and value of each region are discussed in the report along with graphs, tables, and figures.

Competitive Outlook

This chapter of the report discusses the ongoing developments, mergers and acquisitions of leading companies operating in the Animal Stem Cell Therapy market. The product portfolio, pricing strategy, the regional and global presence of each company is thoroughly discussed in the report.

Product Adoption Analysis

The report offers crucial insights related to the adoption pattern, supply-demand ratio, and pricing structure of each product.

Key Participants

The key participants in the animal stem cell therapy market are Magellan Stem Cells, ANIMAL CELL THERAPIES, Abbott Animal Hospital, VETSTEM BIOPHARMA, Veterinary Hospital and Clinic Frisco, CO, etc. The companies are entering into the collaboration and partnership to keep up the pace of the innovations.

The report covers exhaustive analysis on:

Regional analysis for Market includes

Report Highlights:

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Key Takeways Enclosed in the Report:

Queries Related to the Animal Stem Cell Therapy Market Explained:

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Scientists explore using CAR-T and other engineered immune cells to target COVID-19 – FierceBiotech

Posted on April 27, 2020 by Danzig

CAR-T and TCR-T therapies that involve engineering a patients own immune cells with antigen-specific receptors have revolutionized blood cancer treatment. Nowscientists at Duke-NUS Medical School are exploring the possibility of turning the approach against COVID-19.

The idea of using CAR/TCR-T cell therapy has already been proposed for treating chronic viral infections such as HIV and hepatitis B. Based on previous research, Antonio Bertoletti from Duke-NUS emerging infectious diseases research program suggest these immunotherapies might also be useful in treating SARS-CoV-2, the virus causing the current pandemic.

We demonstrated that T cells can be redirected to target the coronavirus responsible for SARS. Our team has now begun exploring the potential of CAR/TCR T cell immunotherapy for controlling the COVID-19-causing virus, SARS-CoV-2, and protecting patients from its symptomatic effects, Bertoletti said in a statement.

Virtual Clinical Trials Online

This virtual event will bring together industry experts to discuss the increasing pace of pharmaceutical innovation, the need to maintain data quality and integrity as new technologies are implemented and understand regulatory challenges to ensure compliance.

These types of therapies involve modifying patients' own T cells with either a chimeric antigen receptor (CAR) or a T-cell receptor (TCR) that can recognize specific antigens associated with cancer,and then guiding the immune cells to eradicate the targets when infused back into the patients.

In a 2011 article published in the Journal of Virology, Bertoletti led a team that generated TCR-T cells that can go after SARS, another coronavirus that caused a deadly outbreak in China and other countries in late 2002 and early 2003.

The team showed that those TCR-redirected T cells displayed a functional profile similar to that of SARS-specific memory CD8 T cells from people who recovered from SARS-CoV infection. Based on the findings, the researchers suggested that TCR-T cells represent a promising prophylactic or therapeutic treatment for SARS.

RELATED:How 'duoCAR-T' cells could clear HIV and prevent resurgence of virus reservoirs

CAR-T cells have been explored in other viruses. A research team from the Albert Einstein College of Medicine and the University of Pittsburgh, for example,designed duoCAR-T cells that target three sites on the HIV envelope glycoprotein. In the lab, the cell therapy eliminated up to 99% of immune cells infected with different strains of HIV.

Despite thepromise of T-cell therapies, however, Bertoletti and colleague Anthony Tanoto Tan cautioned about potential safety concerns of using them to treat viral infections affecting vital organs. For one thing, CAR-T treatments havebeen linked to the dangerous side effect called cytokine release syndrome, in which overreactive immune cells launch an inflammatory response that can destroy organs, they said in a recent Journal of Experimental Medicine commentary. Similar cytokine storm effects have been reported in somesevere COVID-19 patients, leading to potentially life-threatening lung inflammations.

[T]he infusion ofT cells stably expressingpathogen-specific CAR/TCR poses therisk that these T cells might proliferate and wipe out all the infected cells that might be the majority of the infected organ, Bertoletti and Tanoto Tan wrote in their article.

To addressthat problem, Bertoletti and colleagues are using mRNA electroporation to engineer CAR/TCR T cells, which they say can limit their inflammatory capability and shorten the functional activity. That may offer a safer way to use engineered immune cells to treat viral diseases.

Several organizations are also working on cell therapies for COVID-19. AlloVir and Baylor College of Medicine have teamed up to develop an off-the-shelf therapy that entails exposing donor T cells to cytokines combined with viral fragments so the new cells can target the novel coronavirus. Celgene spinoff Celularity just started clinical trial of its cancer treatment CYNK-001 for COVID-19. The drugturns placental stem cells into one-size-fits-all natural killer cells.

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Scientists explore using CAR-T and other engineered immune cells to target COVID-19 - FierceBiotech

Global Animal Stem Cell Therapy Market 2020 Future Scenario, Industry Growth Insights and Production Analysis 2025 – Bandera County Courier

Posted on April 27, 2020 by Danzig

Mrinsights.bizhas published a new report titled GlobalAnimal Stem Cell TherapyMarketGrowth 2020-2025 which comprises new statistical data on the changing market scenario and initial and future assessment of the market. The report covers a wide range of business aspects global Animal Stem Cell Therapy trends, future forecasts, growth opportunities, key end-user industries, and market players. The report analyzes the recent developments, investment opportunities, and probable threats in the market. It closely looks at the markets all-purpose evaluation and depicts the important data associated with the global market.

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The report assesses the demand-side and supply-side trends in the global Animal Stem Cell Therapy market. Various segments are scrutinized that involve end-users, regions, and players on the basis of demand patterns, and prospect for 2020 to 2025 time-period. The research report contains a comprehensive database on future market estimation based on historical data analysis. Key players are listed with major collaborations, mergers & acquisitions and upcoming and trending innovation. Primary research involves interviews, news sources and information booths. Secondary research techniques add more in clear and concise understanding with regards to placing of data in the report.

Understanding The Competitive Scenario:

Competitive landscape analysis is presented which involves the global Animal Stem Cell Therapy market share of major players, along with the new projects and strategies adopted by players in the past five years. Comprehensive company profiles comprise the product offerings, key financial information, recent developments, SWOT analysis, capacity, production, price, revenue, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, and strategies employed by the major market players. Additionally, the report covers insights into the production and capacities in terms of manufacturing with price fluctuations of raw materials, process in-flow rate product cost, and production value.

Considering market analysis, the profiled list of companies in the report is:Medivet Biologics LLC, Animal Cell Therapies, VETSTEM BIOPHARMA, U.S. Stem Cell, Inc, VetCell Therapeutics, J-ARM, Kintaro Cells Power, Celavet Inc., Animal Stem Care, Magellan Stem Cells, Cell Therapy Sciences, Animacel

Currently, the research report gives special attention and focus on the following regions:Americas (United States, Canada, Mexico, Brazil), APAC (China, Japan, Korea, Southeast Asia, India, Australia), Europe (Germany, France, UK, Italy, Russia, Spain), Middle East & Africa (Egypt, South Africa, Israel, Turkey, GCC Countries).

Moreover, the report identifies potential customers and suppliers as well as gives an analysis of the companys business structure, operations, major products and services, and business strategy. The study helps you understand the companys core strengths, weaknesses, opportunities, and threats. The report shows factual data about the global Animal Stem Cell Therapy market in the worldwide area, for example, production chain, manufacturing capacity, sales volume, and revenue.

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The Scope of The Global Animal Stem Cell Therapy Report:

Customization of the Report:This report can be customized to meet the clients requirements. Please connect with our sales team (sales@mrinsights.biz), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +1-201-465-4211 to share your research requirements.

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Global Animal Stem Cell Therapy Market 2020 Future Scenario, Industry Growth Insights and Production Analysis 2025 - Bandera County Courier

Orchard Therapeutics Announces First Patient Dosed with OTL-201 Gene Therapy in Proof-of-Concept Clinical Trial for Sanfilippo Syndrome (MPS-IIIA) |…

Posted on April 27, 2020 by Danzig

DetailsCategory: DNA RNA and CellsPublished on Monday, 27 April 2020 17:10Hits: 34

BOSTON, MA, USAandLONDON, UK I April 27, 2020 IOrchard Therapeutics(Nasdaq: ORTX), a global gene therapy leader, today announced that the first patient has been dosed in an open-label, proof-of-concept investigational study of OTL-201, an ex vivo autologous hematopoietic stem cell (HSC) gene therapy for the treatment of mucopolysaccharidosis type IIIA (MPS-IIIA). The study is designed to evaluate safety, tolerability and clinical efficacy and is intended to enroll up to five patients between three months and 24 months of age who will be followed for three years. The study also contains a number of key secondary outcome measures such as overall survival, cognition and behavior to help inform future clinical development of HSC gene therapy in this indication.

MPS-IIIA, also known as Sanfilippo syndrome type A, is a rare, inherited neurometabolic disorder caused by genetic mutations that leads to the buildup of sugar molecules called mucopolysaccharides in the body, resulting in progressive intellectual disability and loss of motor function. Children born with MPS-IIIA rarely live past adolescence or early adulthood, and no approved therapies currently exist to treat the disease.

I am very encouraged that we, together with our research and clinical collaborators in Manchester, could achieve this important milestone in our efforts to develop a gene therapy for MPS-IIIA despite the current, challenging global health circumstances, saidBobby Gaspar, M.D., Ph.D., chief executive officer of Orchard. It is a testament to the dedication of our collective teams and underscores the truly dire, life-limiting nature of the disease for affected children and their families. This study adds to Orchards clinical pipeline of HSC gene therapies for the treatment of severe neurometabolic disorders and further demonstrates the potential of our platform approach.

About MPS-IIIAMucopolysaccharidosis type IIIA (MPS-IIIA, also known as Sanfilippo syndrome type A) is a rare and life-threatening metabolic disease. People with MPS-IIIA are born with a mutation in theN-sulphoglucosamine sulphohydrolase (SGSH)gene, which, when healthy, helps the body break down sugar molecules called mucopolysaccharides. The buildup of mucopolysaccharides in the brain and other tissues leads to intellectual disability and loss of motor function. MPS-IIIA occurs in approximately one in every 100,000 live births. Life expectancy of children born with MPS-IIIA is estimated to be between 10-25 years.

About OrchardOrchard Therapeutics is a global gene therapy leader dedicated to transforming the lives of people affected by rare diseases through the development of innovative, potentially curative gene therapies. Our ex vivo autologous gene therapy approach harnesses the power of genetically-modified blood stem cells and seeks to correct the underlying cause of disease in a single administration. The company has one of the deepest gene therapy product candidate pipelines in the industry and is advancing seven clinical-stage programs across multiple therapeutic areas, including inherited neurometabolic disorders, primary immune deficiencies and blood disorders, where the disease burden on children, families and caregivers is immense and current treatment options are limited or do not exist.

Orchard has its global headquarters in London and U.S. headquarters in Boston. For more information, please visit http://www.orchard-tx.com, and follow us on Twitter and LinkedIn.

SOURCE: Orchard Therapeutics

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Orchard Therapeutics Announces First Patient Dosed with OTL-201 Gene Therapy in Proof-of-Concept Clinical Trial for Sanfilippo Syndrome (MPS-IIIA) |...

How effective is PLX cell therapy in treating coronavirus? Experts answer all queries and more – India TV News

Posted on April 27, 2020 by Danzig

Pluristem Therapeutics or PLX cell therapyuses placentas to grow smart cells, and programs them to secrete therapeutic proteins in the bodies of sick people. It has just treated its first American COVID-19 patient after treating seven Israelis. The patients were suffering from acute respiratory failure and inflammatory complications associated with Covid-19. Now, this theraphy is being touted as a possible 'cure'' for the deadly coronavirus with scientisst conducting varied researches on the same. In an exclusive interaction with India TV, doctors from India and abroadcame together for discussing about how effective can cell therapy be in treating coronavirus. Dr Solomon from Israel, Dr Anil Kaul from the US, DrSanjeev Chaubey from Shanghai and Dr Padma Srivastv and Dr Harsh Mahajan from India threw light upon the stem cell therapy and the possibility of incorporating the same in treating COVID-19 pateints.

Stem Cell Therapy Market Segmentation, Application, Technology, Analysis Research Report and Forecast to 2026 – Cole of Duty

Posted on April 27, 2020 by Danzig

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Global Stem Cell Therapy Market Segmentation

This market was divided into types, applications and regions. The growth of each segment provides an accurate calculation and forecast of sales by type and application in terms of volume and value for the period between 2020 and 2026. This analysis can help you develop your business by targeting niche markets. Market share data are available at global and regional levels. The regions covered by the report are North America, Europe, the Asia-Pacific region, the Middle East, and Africa and Latin America. Research analysts understand the competitive forces and provide competitive analysis for each competitor separately.

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Stem Cell Therapy Market Region Coverage (Regional Production, Demand & Forecast by Countries etc.):

North America (U.S., Canada, Mexico)

Europe (Germany, U.K., France, Italy, Russia, Spain etc.)

Asia-Pacific (China, India, Japan, Southeast Asia etc.)

South America (Brazil, Argentina etc.)

Middle East & Africa (Saudi Arabia, South Africa etc.)

Some Notable Report Offerings:

-> We will give you an assessment of the extent to which the market acquire commercial characteristics along with examples or instances of information that helps your assessment.

-> We will also support to identify standard/customary terms and conditions such as discounts, warranties, inspection, buyer financing, and acceptance for the Stem Cell Therapy industry.

-> We will further help you in finding any price ranges, pricing issues, and determination of price fluctuation of products in Stem Cell Therapy industry.

-> Furthermore, we will help you to identify any crucial trends to predict Stem Cell Therapy market growth rate up to 2026.

-> Lastly, the analyzed report will predict the general tendency for supply and demand in the Stem Cell Therapy market.

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Table of Contents:

Study Coverage: It includes study objectives, years considered for the research study, growth rate and Stem Cell Therapy market size of type and application segments, key manufacturers covered, product scope, and highlights of segmental analysis.

Executive Summary: In this section, the report focuses on analysis of macroscopic indicators, market issues, drivers, and trends, competitive landscape, CAGR of the global Stem Cell Therapy market, and global production. Under the global production chapter, the authors of the report have included market pricing and trends, global capacity, global production, and global revenue forecasts.

Stem Cell Therapy Market Size by Manufacturer: Here, the report concentrates on revenue and production shares of manufacturers for all the years of the forecast period. It also focuses on price by manufacturer and expansion plans and mergers and acquisitions of companies.

Production by Region: It shows how the revenue and production in the global market are distributed among different regions. Each regional market is extensively studied here on the basis of import and export, key players, revenue, and production.

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Tags: Stem Cell Therapy Market Size, Stem Cell Therapy Market Trends, Stem Cell Therapy Market Growth, Stem Cell Therapy Market Forecast, Stem Cell Therapy Market Analysis

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Stem Cell Therapy Market Segmentation, Application, Technology, Analysis Research Report and Forecast to 2026 - Cole of Duty

Higher Levels of NETs in Blood Associated With More Severe COVID-19 – Technology Networks

Posted on April 27, 2020 by Danzig

New research finds a connection between destructive white blood cells and a more severe disease course in patients with COVID-19.

"We found that patients with COVID-19 infection have higher blood levels of neutrophil extracellular traps, also called NETs, which are a product of an inflammatory type of neutrophil cell death called NETosis," says first author Yu (Ray) Zuo, M.D., a Michigan Medicine rheumatologist.

Zuo worked on the study with Yogen Kanthi, M.D., a cardiologist and vascular medicine specialist at the Michigan Medicine Frankel Cardiovascular Center, and Jason Knight, M.D., Ph.D., a rheumatologist at Michigan Medicine, who study inflammation and neutrophils. The researchers analyzed blood samples from 50 patients with COVID-19 for this publication.

Zuo and colleagues say, in light of the COVID-19 pandemic, there is an urgent need to better understand what causes the inflammatory storm and blood clots triggered by SARS-CoV-2 infection--a storm that leads to respiratory failure and a requirement for mechanical ventilation in many patients. They believe NETs may be relevant to many aspects of COVID-19 research, given that thrombosis and inflammation are hallmarks of severe infection.

This is the first publication to come out of the Frankel CVC's CV Impact Research Ignitor Grant program, which was created to address COVID-19 from both basic science and clinical perspectives.

Reference:Zuo, Y., Yalavarthi, S., Shi, H., Gockman, K., Zuo, M., Madison, J. A., . . . Knight, J. S. (2020). Neutrophil extracellular traps in COVID-19. JCI Insight. doi:10.1172/jci.insight.138999

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Higher Levels of NETs in Blood Associated With More Severe COVID-19 - Technology Networks

Stem Cell Therapy Market to Discern Steadfast Expansion During 2025 – Cole of Duty

Posted on April 27, 2020 by Danzig

Global Stem Cell Therapy Market: Overview

Also called regenerative medicine, stem cell therapy encourages the reparative response of damaged, diseased, or dysfunctional tissue via the use of stem cells and their derivatives. Replacing the practice of organ transplantations, stem cell therapies have eliminated the dependence on availability of donors. Bone marrow transplant is perhaps the most commonly employed stem cell therapy.

Osteoarthritis, cerebral palsy, heart failure, multiple sclerosis and even hearing loss could be treated using stem cell therapies. Doctors have successfully performed stem cell transplants that significantly aid patients fight cancers such as leukemia and other blood-related diseases.

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Global Stem Cell Therapy Market: Key Trends

The key factors influencing the growth of the global stem cell therapy market are increasing funds in the development of new stem lines, the advent of advanced genomic procedures used in stem cell analysis, and greater emphasis on human embryonic stem cells. As the traditional organ transplantations are associated with limitations such as infection, rejection, and immunosuppression along with high reliance on organ donors, the demand for stem cell therapy is likely to soar. The growing deployment of stem cells in the treatment of wounds and damaged skin, scarring, and grafts is another prominent catalyst of the market.

On the contrary, inadequate infrastructural facilities coupled with ethical issues related to embryonic stem cells might impede the growth of the market. However, the ongoing research for the manipulation of stem cells from cord blood cells, bone marrow, and skin for the treatment of ailments including cardiovascular and diabetes will open up new doors for the advancement of the market.

Global Stem Cell Therapy Market: Market Potential

A number of new studies, research projects, and development of novel therapies have come forth in the global market for stem cell therapy. Several of these treatments are in the pipeline, while many others have received approvals by regulatory bodies.

In March 2017, Belgian biotech company TiGenix announced that its cardiac stem cell therapy, AlloCSC-01 has successfully reached its phase I/II with positive results. Subsequently, it has been approved by the U.S. FDA. If this therapy is well- received by the market, nearly 1.9 million AMI patients could be treated through this stem cell therapy.

Another significant development is the granting of a patent to Israel-based Kadimastem Ltd. for its novel stem-cell based technology to be used in the treatment of multiple sclerosis (MS) and other similar conditions of the nervous system. The companys technology used for producing supporting cells in the central nervous system, taken from human stem cells such as myelin-producing cells is also covered in the patent.

The regional analysis covers:

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Global Stem Cell Therapy Market: Regional Outlook

The global market for stem cell therapy can be segmented into Asia Pacific, North America, Latin America, Europe, and the Middle East and Africa. North America emerged as the leading regional market, triggered by the rising incidence of chronic health conditions and government support. Europe also displays significant growth potential, as the benefits of this therapy are increasingly acknowledged.

Asia Pacific is slated for maximum growth, thanks to the massive patient pool, bulk of investments in stem cell therapy projects, and the increasing recognition of growth opportunities in countries such as China, Japan, and India by the leading market players.

Global Stem Cell Therapy Market: Competitive Analysis

Several firms are adopting strategies such as mergers and acquisitions, collaborations, and partnerships, apart from product development with a view to attain a strong foothold in the global market for stem cell therapy.

Some of the major companies operating in the global market for stem cell therapy are RTI Surgical, Inc., MEDIPOST Co., Ltd., Osiris Therapeutics, Inc., NuVasive, Inc., Pharmicell Co., Ltd., Anterogen Co., Ltd., JCR Pharmaceuticals Co., Ltd., and Holostem Terapie Avanzate S.r.l.

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Stem Cell Therapy Market to Discern Steadfast Expansion During 2025 - Cole of Duty

Global Nerve Repair and Regeneration Market (2019 to 2025) – Analysis, Trends, and Forecasts – ResearchAndMarkets.com – Business Wire

Posted on April 27, 2020 by Danzig

DUBLIN--(BUSINESS WIRE)--The "Nerve Repair and Regeneration - Market Analysis, Trends, and Forecasts" report has been added to ResearchAndMarkets.com's offering.

The Nerve Repair and Regeneration market worldwide is projected to grow by US$7.1 Billion, driven by a compounded growth of 12.1%. Neurostimulation & Neuromodulation Devices, one of the segments analyzed and sized in this study, displays the potential to grow at over 12.3%. The shifting dynamics supporting this growth makes it critical for businesses in this space to keep abreast of the changing pulse of the market. Poised to reach over US$11.8 Billion by the year 2025, Neurostimulation & Neuromodulation Devices will bring in healthy gains adding significant momentum to global growth.

Representing the developed world, the United States will maintain a 11% growth momentum. Within Europe, which continues to remain an important element in the world economy, Germany will add over US$339.2 Million to the region's size and clout in the next 5 to 6 years. Over US$405.8 Million worth of projected demand in the region will come from Rest of Europe markets. In Japan, Neurostimulation & Neuromodulation Devices will reach a market size of US$527.3 Million by the close of the analysis period. As the world's second largest economy and the new game changer in global markets, China exhibits the potential to grow at 16.1% over the next couple of years and add approximately US$1.4 Billion in terms of addressable opportunity for the picking by aspiring businesses and their astute leaders.

Presented in visually rich graphics are these and many more need-to-know quantitative data important in ensuring quality of strategy decisions, be it entry into new markets or allocation of resources within a portfolio. Several macroeconomic factors and internal market forces will shape growth and development of demand patterns in emerging countries in Asia-Pacific, Latin America and the Middle East. All research viewpoints presented are based on validated engagements from influencers in the market, whose opinions supersede all other research methodologies.

Competitors identified in this market include, among others:

Key Topics Covered:

I. INTRODUCTION, METHODOLOGY & REPORT SCOPE

II. EXECUTIVE SUMMARY

1. GLOBAL MARKET OVERVIEW

2. FOCUS ON SELECT PLAYERS

3. MARKET TRENDS & DRIVERS

4. GLOBAL MARKET PERSPECTIVE

III. MARKET ANALYSIS

IV. COMPETITION

For more information about this report visit https://www.researchandmarkets.com/r/dhc95v

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Global Nerve Repair and Regeneration Market (2019 to 2025) - Analysis, Trends, and Forecasts - ResearchAndMarkets.com - Business Wire

Futurist Transhuman News Blog

Monthly Archives: April 2020

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Faith and Values: What the butterfly effect can teach us about the coronavirus and spirituality – The Spokesman-Review

Wiring the Quantum Computer of the Future: Researchers from Japan and Australia propose a novel 2D design – QS WOW News

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100 years later, where is the physics department now? – The Daily Evergreen

Theoretical Predictions of High-Energy-Density Physics Shed Light on the Universe – AZoQuantum

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Stem Cell Therapy Shows 83% Survival in COVID-19 Patients Dependent on Ventilator – HospiMedica

Coronavirus Q&A: Dr. Camillo Ricordi Gives Update On Trials Of Stem Cell Treatment For Most Severe COVID-19 Cases – CBS Miami

Impact of COVID-19 on Stem Cell Therapy Market Investment Opportunities And Forecast 2020-2027 | By Top Key Players Magellan, Medipost Co., Ltd,…

World coronavirus Dispatch: Animal Stem Cell Therapy Market Forecasted To Surpass The Value Of US$ XX Mn/Bn By 2036 2017 2025 – Latest Herald

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Global Animal Stem Cell Therapy Market 2020 Future Scenario, Industry Growth Insights and Production Analysis 2025 – Bandera County Courier

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How effective is PLX cell therapy in treating coronavirus? Experts answer all queries and more – India TV News

Stem Cell Therapy Market Segmentation, Application, Technology, Analysis Research Report and Forecast to 2026 – Cole of Duty

Higher Levels of NETs in Blood Associated With More Severe COVID-19 – Technology Networks

Stem Cell Therapy Market to Discern Steadfast Expansion During 2025 – Cole of Duty

Global Nerve Repair and Regeneration Market (2019 to 2025) – Analysis, Trends, and Forecasts – ResearchAndMarkets.com – Business Wire