Scientists who cloned Dolly the sheep ‘in talks over coronavirus treatment’ – Metro.co.uk

The lab which helped to clone Dolly the sheep are set to help in the fight against Covid-19 (Picture: PA)

The scientists responsible for cloning Dolly the sheep are reportedly in talks with the Government over a potential coronavirus treatment.

Researchers from TC Biopharm near Glasgow have used the new therapy which uses immunity-building cell transfusions to successfully treat cancer and plan to use immune cells from young and healthy volunteers to battle Covid-19.

The Daily Telegraph reported they are now hoping it will also work against the virus, and are in talks with the Government to trial the therapy for that purpose. It is hoped that the therapy will be available in NHS hospitals by July.

Dr Brian Kelly, senior strategic medical adviser to TC Biopharm, told the paper: One of the key challenges of fighting viral infection is to develop something that is going to attack the infected cells and not the normal cells.

So the solution that we came up with was to look at the bodys natural defences to viral infection.

Dr Kelly continued: In patients who have successfully fought a viral infection, they have expanded their own immune system and that persists after that to stop them becoming infected again.

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For all the latest news and updates on Coronavirus,click here.

The donor T-cells differ from normal immune cells. That is because they do not identify invaders in the body based on alien protrusions on the surface of cells, but by detecting the unusual metabolism of viruses.

When the donor cells detect a virus, they begin to destroy while also signalling it to the rest of the immune system as an alien intrusion requiring eradication.

Dr Kelly said that with this approach even if the virus mutated and returned to a body the infusion exercise could be repeated and would still work.

TC Biopharm was founded by Angela Scott, who was part of the team who cloned Dolly the Sheep in Edinburgh in 1996 in an iconic scientific moment.

There is currently no cure for Covid-19 though various vaccines are at different stages in their development across the world.

Today the UK recorded another surge in deaths linked to people hospitalised with Covid-19, as a toll of 708 brought the official total to more than 4,000.

Get in touch with our news team by emailing us atwebnews@metro.co.uk.

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Cat Cloning Market Analysis With Key Players, Applications, Trends And Forecasts To 2026 – Science In Me

Cat Cloning Market Forecast 2020-2026

The Global Cat Cloning Market research report provides and in-depth analysis on industry- and economy-wide database for business management that could potentially offer development and profitability for players in this market. This is a latest report, covering the current COVID-19 impact on the market. The pandemic of Coronavirus (COVID-19) has affected every aspect of life globally. This has brought along several changes in market conditions. The rapidly changing market scenario and initial and future assessment of the impact is covered in the report. It offers critical information pertaining to the current and future growth of the market. It focuses on technologies, volume, and materials in, and in-depth analysis of the market. The study has a section dedicated for profiling key companies in the market along with the market shares they hold.

The report consists of trends that are anticipated to impact the growth of the Cat Cloning Market during the forecast period between 2020 and 2026. Evaluation of these trends is included in the report, along with their product innovations.

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The Report Covers the Following Companies:Sinogene Pet CloningSooam BiotechViaGen PetsBoyalifeMy friend Again

By Types:From Deceased CatsFrom Live Cats

By Applications:Pet CatOthers

Furthermore, the report includes growth rate of the global market, consumption tables, facts, figures, and statistics of key segments.

By Regions:

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Years Considered to Estimate the Market Size:History Year: 2015-2019Base Year: 2019Estimated Year: 2020Forecast Year: 2020-2026

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About Industrygrowthinsights:Industrygrowthinsights has set its benchmark in the market research industry by providing syndicated and customized research report to the clients. The database of the company is updated on a daily basis to prompt the clients with the latest trends and in-depth analysis of the industry. Our pool of database contains various industry verticals that include: IT & Telecom, Food Beverage, Automotive, Healthcare, Chemicals and Energy, Consumer foods, Food and beverages, and many more. Each and every report goes through the proper research methodology, validated from the professionals and analysts to ensure the eminent quality reports.

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10 Popular Anime Of The 80s That Time Has Forgotten | CBR – CBR – Comic Book Resources

During the 1980s, there was a gradual shift in the anime form. New animation technology was being reached and stories started to get bolder. Creators were able to do more anime that weren't just the standard shonen or shojo of the Osamu Tezuka or Go Nagai era but rather strived to become something else. Anime such as the groundbreaking Akira directed by Katsuhiro Otomo which helped lay the groundwork for future animes. Whileanimes like Akira have stuck with the viewer subconscious, there are some anime during the 80s that faded away from the casual eye.

Related: Every Katsuhiro Otomo Movie Ranked, From Worst To Best (According To IMDB)

Here are the 10 Popular Anime Of The 80s That Time Has Forgotten.

A science-fiction anime that came out in 1987, Royal Space Force: The Wings Of Honneamise, stars Shirotsugh who after being inspired by a woman named Riquinni, becomes the first astronaut in an alternate world. Directed and written by Hiroyuki Yamaga and composed by award winner Ryuichi Sakamoto, crafts an anime tale that's a coming of age story filled with personal strife.

Related: Gurren Lagann: 10 Reasons Why It's A Much-Watch Anime Series

A fun fact about this anime is that it was the first production from Studio Gainax, the same studio that created the super popular Neon Genesis Evangelion and later Tengen Toppa Gurren Lagann.

Released in 1985 to director Mamoru Oshii and designed by Yoshitaka Amano of Final Fantasy fame, the film is 71 minutes that is more akin to visualart rather than telling a proper story. The science fantasy anime tells the story of an unnamed girlliving in an abandoned city finding food, caring for a mysterious egg. The film was critically panned by critics who criticized it's often sparse structure, but despite not finding work for years, Mamoru Oshii considers it one of the highlights of his career. Since then, the director has created many acclaimed animes including 1995's Ghost in the Shell.

Based on the 1978 manga simply called Cobra, the film was released in 1982 and it was directed by Osamu Dezaki. This science-fiction anime stars the titular Cobra as he's asked by the beautiful Jane Royal to stop the pirate guild and Crystal Bowie, Cobra's arch-nemesis. Cobra is armed with a special weapon called the "Psychogun" which is grafted on his left hand.

Related: 15 Best Sci-Fi Anime To Watch Right Now

The film has created a following amongst anime lovers and has inspired the likes of Hideki Kamiya when he developed the character of Dante in the legendary Devil May Cry franchise. Notably from the character's mannerisms and personality.

Produced by Kitty Films and running from 1981 to 1986, Urusei Yatsura stars Ataru Moroboshi, a perverted high schooler who is chosen by the alien race known as the Oni, to participate in their game. By touchingthe horns of an opposing Oni, humanity is able to retain the right to live on planet earth.

Related: Inuyasha: 10 Best Fights On The Show

After touching the horns of the oni, Princess Lum Invader, the anime shifts focus on being a slice of life focusing on the daily lives of both Ataru and Lum who sticks around after Ataru accidentally proposes to her. With twelve OVAs, six films and over 195 episodes, the series helped launch Rumiko Takahashi's career. Eventually creating the series known as Inuyasha.

Another Takahashi creation, Ranma 1/2 is a comedy anime produced by Studio Deen, taking place in the Chinese province of Qinghai. After falling into the cursed springs of Jusenkyo, Ranma and his father learn that they are able to transform into another being. Ranma is able to change genders while his father is able to turn into a fearsome panda. The anime is filled with the relationships between the main cast and supporting characters, which help drive the plot of the story. Combined with the arranged marriage overtone between Ranma and his betrothed Akane, creates an anime that became one of Takahashi's finest works.

Based on the manga created by Masami Yuki, Patlabor is a science fiction anime film directed by Mamoru Oshii and written by Kazunori Ito. The team behind the Ghost in the Shell film. Similar to Ghost in the Shell, Patlabor takes place in a technologically advanced Japan set during the year 1999. The Tokyo Metropolitan Police Department is ordered to take down rogue robot units known as Labors, after they went haywire even after being shut down. One of the earliest works done by Production I.G,the film was a part of a franchise that contained several OVAs, light novels and sequel films.

A Japanese OVA, the dark fantasy anime Wicked City takes place near the tail end of the 20th century. Here, humanity is secretly co-existing with the demon world with the Black Guard police force being the bridge between the two. Incredibly erotic and violent, the production was the debut of director Yoshiaki Kawajiri. Best known for future anime works such as Ninja Scroll and the second Vampire Hunter D film, Vampire Hunter D: Bloodlust. The film later got a live-action adaptation in Hong Kong also called Wicked City, although it changed aspects of the film such as thedemons being replaced with "Rapters"and overall creative liberties with the plot.

The original Vampire Hunter D film, produced in 1985, is a science fiction dark fantasy film about a vampire hunter simply called "D." Taking place in the far-flung future of 12,090 AD, D is hired by a girl named Doris Lang in order to protect her from the powerful vampire lord known as Count Lee.

Related: Vampire Hunter D: The 10 Scariest Moments In The Movies

Originally a series of novels with illustrations by Final Fantasy's Yoshitaka Amano, the film has since garnered a cult following amongst its American fanbase and was the first of many media adaptations of the franchise.

The other creation of Masamune Shirow's works, along with Ghost in the Shell, the 1988 OVA adaptation byStudio Gainax takes place in a post World War 3 Japan. Set in a fictional city called Olympus, the denizens of the city are humans, cyborgs and biological artificial beings known as the Bioroids. Sharing elementsrelating to post-humanism,the concept of a utopia and being an overall cyberpunk crime thriller, Although not as famous as Ghost in the Shell,Appleseed is still arguably a solid companion piece to those more familiar to Shirow's more famous work.

A Japanese OVA series produced by Studio Gainax between 1988 and 1989, it's directed by the creator of future Neon Genesis Evangelion fame, Hideaki Anno. Inspired by Top Gun, the anime takes place in the future of 2023 where humanity is fighting against an alien race known as the Uchuu Kaiju using giant mechas.

Running for about 6 episodes, the anime is considered the spiritual predecessor to Neon Genesis Evangelion, having a couple of elements following up from the anime. Sharing elements such as young teenage characters and giant robots fighting against an extraterrestrial threat.

Next: One & Done: The Best Single-Season Anime To Binge Right Now

NextOne Piece: 5 Characters Sanji Will Surpass (& 5 He Won't)

Richie Nguyen is an aspiring comic book creator and journalist living in Calgary Alberta. A lover of anything pop culture since childhood, Richie Nguyen is sure to write plenty about the newest comic book, manga and movie news. Having written journalistic coverage during his time at Mount Royal University's Calgary Journal, as well as interning in Tourism Calgary, Richie has plenty of experience writing things from general news to listicles. Outside of work, Richie actively plays video games, spends time with his family and friends, and of course drawing to one day achieve his dream.

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10 Popular Anime Of The 80s That Time Has Forgotten | CBR - CBR - Comic Book Resources

10 Web Design and UX Trends to drive better conversion rate – TechGenyz

Whats the very first thing a website visitor observes on your website? Or lets say what the first thing that draws customer attention is? Animations, graphics, color selection, logo all these things draw the first impression of your website and this helps the person to decide whether he will stay on the website or leave it right away.

Well, in the ever-evolving and fast digital world, you only get a few seconds to impress the customers with your web design; else the person will look for some other alternate and eventually invest in some of your strong competitors.

When the industry competition is becoming tougher day after day and with the growing demands and expectations of the website visitors, you need to plan a web design strategy that will not only attract the people but also results in a higher conversion rate. So, in this post, well explore a list of popular web design and UX trends that major industry leaders practice in 2020 so as to stay ahead of the race.

Lets get started!

No doubt, the technology has led us to go the extra mile from desktop views to smartphones, tablets, and other devices support. All thanks to the mobile-first design that has offered an outstanding user experience.

However, we are far away from designing content that is compatible with all sorts of devices smartwatches, desktops, phones, websites, and so on. There are voice platforms, personal assistant apps, or devices connected by the Internet of Things, in this case, we need to focus upon a content-first approach rather than only working upon the mobile-first design. This will definitely help in attracting a wider audience towards your business.

Users are always looking for innovative and impressive things over a website. The latest technologies in the design industry that are expected by the users will include vibrant, bright, and highly saturated colors. Numerous other color schemes will accompany gradients, surrealism, and pre-posthumanism that carry their own set of characteristics and feel to impress the customers in recent times and bring them towards your business.

So, in the coming time, customers will simply love and get attracted to bold, bright, and vibrant colors. Having a demanding and accurate color palette that has a set of lively colors is what businesses are going to focus on in the coming decade.

Contextual photography is basically an image that will capture a lot more than the subject and comprise of images that will help your brand connect with a sensory emotion and help your business stand unique from the rest of the competition. It will eventually help the customers grab attention towards your brands simply with the help of appealing images that clearly convey your business idea and products.

Nowadays, customers are getting more attracted to appealing videos since it consumes less time and is an attractive way to grab information. Businesses have started making videos for tutorials, social media ads, and even web banners in the form of GIFs, animations, and short videos.

Since people no more prefer reading lengthy text and love watching short videos, this is the reason videos have become a powerful marketing tool in todays time so as to grab a wider customer audience and experience better conversion rates.

Personalization has remained a buzzword for a long time, but the technical skills to implement it the right way has come just a year back. Well, personalization is just not confined to addressing a user by his name, however, it is about focusing on the customer interests, while the users are going through the purchasing process, and a tailored message is sent to direct them to the next step.

Since the customers experience a memorable journey over your website, they would definitely love continuing over your website.

Micro-interactions are ultimately getting the attention and appreciation it deserves. Designers know it very well that they have been waiting for this. Micro-interactions are soon going to become mainstream now. Well, micro-interactions are basically visual responses or animations customers will see while performing certain activities.

Micro-interactions will inform the customers while they successfully make a payment, added a product in the wishlist, or posted a review. It will further help in improving the navigation of the website and deliver a great experience while bringing the customers near to the conversions.

More and more industry leaders are planning to invest and work upon multistep forms this year. Multi-step forms will build the threatening parameter of lengthy forms and improve engagement with the help of touch gestures and micro interactions while reducing typing and deliver a rich experience to the users than ever before.

It is defined as the technique to arrange type for making written impressive while displaying. Emphasizing text is as important as focusing on the colors, thereby it becomes necessary for a business to work upon typography design in order to get better conversions. During this, you must focus on text size, font selection, tracking and kerning, leading, measure, and hierarchy.

Better the typography is, better your brand name will be in the market. Moreover, users not only prefer text, which seems appealing, but the one which is easy to navigate and well organized. So, make sure you use bullets wherever required, add titles, subheadings, and even try highlighting the important things throughout the text.

Masking is a technique that already many websites are using nowadays the tool hides specific areas of the image and reveals the other areas. This presents a mysterious view of the image and is quite appealing to the customers end. Since it has a contemporary look, it is becoming a popular trend in the entire design industry. The majority of the masking evidence and live examples can be seen on front pages, titles, and header sections.

Another thing that technology surprises us with is predictive analytics, which will be available for all-sized brands. In the coming time, predictive analytics tools will become an ordinary thing as email marketing platforms and landing page builders that further helps you transform your existing data in some competent predictions and higher conversion rates.

For instance, with predictive analytics, you can expect an advertising campaign that automatically adjusts as per the recent trend, weather, and all other important parameters that further helps in improving the conversion rates. To make this successful, predictive analysis maps the data history, spotting patterns, and detect the scenarios where adjustments can be made.

As technology and the web design industry continue to evolve and grows every day, we can expect more and more trends that will dominate the web design industry. However, the above web design trends that are expected to stay in the industry for 2020 and beyond. Masking, color schemes, predictive analytics, videos, all these trends are definitely going to bring a wider audience towards your business with fewer efforts. It further enables you to turn those website visitors into loyal leads, stay ahead of the competitors, and boost the conversion rates as never before.

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10 Web Design and UX Trends to drive better conversion rate - TechGenyz

This tiny island nation is setting the global standard for ocean conservation – AOL

Seychelles may be tiny, but the work its residents have done to protect its bustling marine life and gorgeous waters has an enormous impact.

The archipelago of 114 islands, located in the Indian Ocean off the coast of East Africa, is home to numerous beaches, coral reefs and rare animals.

Thanks to a new initiative, more than 30 percent of the countrys waters are now protected. The government has placed restrictions on environmentally damaging activities, such as certain types of fishing and human interference.

The protected area around Seychelles stretches about 171,000 square miles a portion of the globe nearly 1,000 times larger than the countrys own landmass.

Credit: Getty Images

Danny Faure, the president of Seychelles, said in a speech that meeting this goal means a lot for the countrys current residents, and for all future generations as well.

According to the Associated Press, he made a global plea for stronger protection of the beating blue heart of our planet.

We have a relationship with nature, and we depend on the ocean, he continued. And achieving this is a very strong message.

Only seven percent of the worlds oceans are currently protected. A few countries have pledged to increase those areas by 10 percent, but experts say its not enough.

Credit: Getty Images

Patricia Scotland, Secretary-General of the Commonwealth, says Seychelles is setting the standard for much larger countries.

Lots of people are saying, So, whats our excuse? Were bigger, we are wealthier. Is it that we lack commitment? And if we lack commitment, how can we change that?' she told the Associated Press. But for some people, theyre saying; We dont lack commitment, we just dont know how to do it.'

Leo Barret and his colleagues from the Marine Conservation Society Seychelles have been working to establish coral nurseries to help restore reefs near the country just one of the many steps Seychelles has taken to restore marine life.

What do you want your grandchildren to see? Do you want them to see a sea full of plastic pollution, full of bottles? he told the Associated Press.

Or [do] you want to be able to show the future generation coral reef, the fish biodiversity, this is something specific from the ocean, specific on the earth? I think we need to preserve that.

If you enjoyed this story, you may also like reading about how canners are making New York more eco-friendly.

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This tiny island nation is setting the global standard for ocean conservation - AOL

After Trump, Bolsonaro thanks Modi for supply of anti-malarial drug – Livemint

NEW DELHI :India woke up on Thursday to public expressions of thanks from the presidents of the US and Brazil for quick shipments of an anti-malaria drug, which is being tested as a possible treatment for covid-19, as infections from the novel coronavirus inched towards the 1.5-million mark worldwide and the death toll neared 90,000.

The messages from presidents Donald Trump of the US and Jair Bolsonaro of Brazil came as New Delhi prepared to ship consignments of the drug to some other countries badly hit by the pandemic like Britain, Spain, the UK and Germany.

New Delhi is also planning to dispatch medicines to some of its immediate neighbours, and others, such as Mauritius, Seychelles and Bahrain, in Indias extended neighbourhood, a person familiar with the developments said.

Indias supplies of medicines, especially #HCQ (hydroxychloroquine) and #paracetamol to several countries, including USA, Israel, Gulf, neighbours, etc confirm our role as first provider and help in global fight against #COVID19," Sanjay Bhattacharyya, secretary in Indias foreign ministry said in a Twitter post on Thursday.

Analysts said Indias so-called medical diplomacy" by first lifting an exports ban on hydroxychloroquine, or HCQ, in response to requests from several nations will burnish its credentials as a responsible citizen of the world" at a time when China is facing flak over its alleged lack of transparency over the covid-19 outbreak. The disease first surfaced in China in December. The UN Security Council is to meet later Thursday for a special briefing on the pandemic.

Extraordinary times require even closer cooperation between friends. Thank you India and the Indian people for the decision on HCQ. Will not be forgotten! Thank you Prime Minister @NarendraModi for your strong leadership in helping not just India, but humanity, in this fight!" Trump said in a Twitter post late Wednesday.

Bolsonaro, on his part, thanked India for the timely assistance" in an address to the nation made late Wednesday.

As a result of my direct conversation with the Prime Minister of India, we will receive, until Saturday, raw material to continue producing hydroxychloroquine, so that we can treat covid-19 patients, as well as malaria, lupus and arthritis," Bolsonaro said.

I thank Prime Minister Narendra Modi and the Indian people for this very timely assistance to the Brazilian people," he added.

Both leaders had telephonic talks with Modi on Saturday.

Former foreign secretary Lalit Mansingh said Indias quick response to Trumps request of releasing the HCQ would score points in its favour given that US drug companies have been critical of India producing low-cost generic drugs in the past and New Delhi capping costs of critical medicines and equipment manufactured by the multinational firms in the past.

Mansingh noted that India had previously fallen foul of the large pharmaceutical companies for alleged intellectual property rights (IPR) violations as they produced generic drugs to treat HIV-AIDS.

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After Trump, Bolsonaro thanks Modi for supply of anti-malarial drug - Livemint

SIMPSONS short Playdate with Destiny heading to Disney+ – Comics Beat

The Simpsons short Playdate with Destiny will be available for streaming on Disney+ beginning Friday, April 10th. The Disney+ Twitter account announced the shorts streaming release with a handwritten letter from the Simpsons team.

The short, which stars Maggie Simpson, previously ran before PixarsOnward in theaters.But with movie theaters closed due to COVID-19, Disney moved up the streaming release date forOnward, which was made available on Disney+ last Friday, April 3rd.

Tomorrow, Playdate with Destiny will join the feature on Disney+, with the 2012 Simpsons short The Longest Daycare, being added to the streaming service later in the month. In The Longest Daycare, Maggie must survive a day at the Ayn Rand School for Tots (introduced in the classic season 4 Simpsonsepisode A Streetcar Named Marge).

If thats not enough Simpsons for you, there are a plethora of episodes available for your perusal right now: Disney+ currently has a whopping 30 (thatsthirty) seasons ofMatt Groenings seminal family sitcom. Thats over six hundred episodes, all ready to stream right now while you kill time waiting for Playdate with Destiny to be added tonight.

And dont forget one of the Simpson familys otherprevious outings on the big screen, 2007sThe Simpsons Movie, which includes a scene whereTom Hanks delivers a public service message in lieu of the United States government, which is forced to acknowledge that Hanks is a far more credible source of information than any Federal mouthpiece (huh, sounds familiar, for some reason).

If youre interested in streaming the thirty-first and current season ofThe Simpsons, it is currently available for streaming on Hulu, including the most recently aired episode, Highway to Well, which first aired on March 22nd. Also available for streaming on Hulu is Groenings other classic animated series,Futurama.

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SIMPSONS short Playdate with Destiny heading to Disney+ - Comics Beat

Opinion: Alberta separation was always a bad idea, and COVID-19 has shown it’s never going to happen – The Globe and Mail

A crowd attends a Wexit Alberta rally in Calgary on Nov. 16, 2019.

Todd Korol/Reuters

Max Fawcett is a freelance writer and a former editor of Alberta Oil magazine and Vancouver magazine

In politics, timing is everything. And when it comes to Albertas burgeoning separatist movement, the timing of COVID-19 couldnt be much worse. It was just last October, in the wake of the federal Liberal governments re-election, that it appeared to be building some momentum. And while Alberta Premier Jason Kenney argued that he didnt share their ultimate objective, he did effectively legitimize many of their other priorities by striking the Fair Deal panel to assess their merits. Their final report was due last week, but any recommendations it contains are almost certainly moot.

Thats because the fallout from COVID-19 is serving as a powerful reminder of how much we depend on each other and how much well need to keep doing that as we emerge from its shadow. For most of us, this growing sense of social and national solidarity is a good thing.

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But for Albertas separatist movement, its a major setback. Thats because, just as there are no atheists in foxholes, there wont be many people who believe theyre better off on their own after this pandemic finally passes. As Albertans stare at the possibility of an economic downturn thats reminiscent of the Great Depression, some of them are realizing they could use a little help from their friends even the ones they dont particularly like.

This is a nightmare for those who have been dreaming about an independent Alberta, one thats equal parts political revenge fantasy and Ayn Rand fan-fiction. Only once unshackled from the burdens of supporting the rest of the country and the ungrateful people in it who were holding them down, it suggests, will their province truly flourish.

The combination of their oil and gas resources and a determination to see them fully and unapologetically exploited would mean lower taxes, better services, more freedom and a long-overdue opportunity to watch the eastern bastards freeze in the metaphorical dark.

But that dream deliberately ignored the contributions that the federal government had made to their province and its oil and gas industry. It was the federal government that helped fund the oil sands in their earliest days and helped rescue them when a key American backer pulled out of the Syncrude consortium in 1973.

It was the federal government that implemented important tax changes in the 1990s that made the oil sands a far more attractive investment and helped kick off a decades-long building boom that disproportionately benefited Alberta. And it was the federal government that bought and is building the Trans Mountain Expansion Project, effectively doing for Alberta what the private sector couldnt or wouldnt.

The separatist dream of an independent Alberta also conveniently overlooks the fact that separating from Canada wouldnt mean separating from geography. British Columbia would still stand between Alberta and the Pacific Ocean, and the vast majority of its residents would want no part of a right-wing Libertarian petrostate, to say nothing of the many untreatied Indigenous communities who have made their feelings about Albertas favourite industry clear.

And as Assembly of First Nations National Chief Perry Bellegarde has said, the Indigenous communities that do have treaties with the federal government expect those to be respected. You have to be careful when you go down that road of Western alienation, Western exit, he told the CBC. We have inherent rights; we have treaty rights, and those are international agreements with the Crown.

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I dont expect everyone who showed up at last falls pro-separation meetings to give up on their dream. There will always be a radical fringe of people who believe that Alberta would be better off if it separated from Canada, facts be damned, just as there will always be people who believe that the real source of climate change is the sun.

But I do hope that politicians such as Jason Kenney and Michelle Rempel, who have carefully nurtured the idea that Albertans are being mistreated by the federal government and used that feeling to advance their own political objectives and agendas, will stop trading in this fiction. Mr. Kenneys equalization referendum, for example, is a cynical effort to feed the sense of alienation rather than fix it. Now, more than ever, we need to be building bridges between different parts of the country, not trying to blow them up.

I also expect the federal government to rise to the occasion here, and use its financial clout to help the province that has done so much to help the rest of the country. For years, Alberta taxpayers made contributions to the federal treasury that werent matched by the transfers coming back, and the imbalance between the two fed the growing sense of alienation in places such as Calgary and Red Deer.

Now, its time for Ottawa to repay that debt. If it comes through with a sufficiently ambitious rescue package, it could even heal the divisions that have persisted between the two levels of government for so long and put an end to Albertas separatist movement in the process.

Alberta Premier Jason Kenney says Alberta will invest $1.1-billion and give loan guarantees to help Calgary-based TC Energy Corp. build its US$8-billion Keystone XL Pipeline project. The Canadian Press

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Opinion: Alberta separation was always a bad idea, and COVID-19 has shown it's never going to happen - The Globe and Mail

Disease is the greatest threat to bee health. Can we protect them through genetically engineered probiotics? – Genetic Literacy Project

If you cannot engineer the organism, engineer its microbiome.

Since scientists began exploring how to solve problems using synthetic biology, by focusing on microbial symbionts, a whole universe of possibilities has opened up. We have seen a hangover cure, synthetic probiotics for humans, and even microbes that help plants fix their own nitrogen. Now the focus is on bees to get their engineered probiotic, an idea that may save the insects from disease and insulate consumers from food shortages.

Domesticated bees and other pollinators play a significant role in growing many foods, although how much is debated. A significant percentage of Americas crops between 7% and 35% relyto some extent on bees. Wheat, corn and rice are wind-pollinated. Lettuce, beans and tomatoes are self-pollinated. But in some crops, bees are essential. Honeybees have a tremendous financial importance, not only for their honey but as the insects that enable the reproduction of (many) flowering plants. As wild insects cannot be relied upon to pollinate thousands of acres of monocultures, crop producers employ beekeepers to bring their hives close to their plants. This gave birth to migratory beekeeping, a practice now essential for cultivation of plants such as almond trees on a commercial scale.

Honeybees have evolved into a managed livestock, with a complex role in agriculture and established production and management practices. Beekeepers need to maintain healthy colonies. All bee colonies decline significantly in size during the winter months, but overwinter losses have increased over the past 15 years, and now hover around 40%. These persistently high mortality rates have fedinaccurate speculations about the cause, often blaming one class of pesticides, neonicotioids as the primary culprit. The evidence doesnt support that claim. The driver of bee health problems is known and its not pesticides nor agricultural production models; its disease.

Honeybees are susceptible to many infections from parasites and viruses. In fact, the co-infection with mite parasites and RNA viruses is particularly destructive for bees and accounts for a large portion of colony losses. The most common external parasites are the Varroa mites (scientific name Varroa destructor), which feed on the fat bodies of the bees. The deformed wing virus is another common hazard. This RNA virus uses the Varroa mites as disease vectors and infects the bee bodies, leading to developmental deformities.

Varroa infection treatment is difficult. Common methods include pesticides to which Varroa started developing resistance mechanical screening of bees, as well as teaching the bees to recognize and kill infected pupae. A more selective and effective treatment could save bees and agricultural resources, and this treatment might be already present in the bees gut microbiome.

In animals, DNA stores the genetic material, and RNA molecules are short-lived and execute specific functions. Ribosomal RNA has structural role in ribosomes, transport RNA carry amino acids, and messenger RNA carries the information needed to synthesize proteins. In contrast, many viruses carry their genetic information in RNA molecules. To defend against RNA viruses, cells have developed a sophisticated system called RNA interference, or RNAi. This complex molecular machinery recognizes double-stranded RNA and breaks it down.

Bees possess an efficient RNAi machinery that protects them from intruders at a molecular level. And researchers can use this system to protect bees against mites and viruses. If we insert RNA complimentary to the deformed wing viruss genome, it will form a double-stranded hybrid molecule. The RNAi machinery can now shred the virus genome to pieces, ending thus the virus infection. The same principle can be used to target specific parasite genes. And this brought forth the idea of injecting bees with RNA to protect against Varroa mites.

There are several problems with administering RNA to individual bees. RNA is a notoriously unstable and difficult to administer molecule. The treatment is short-termed. There are off-target effects. And its almost impossible to treat entire hives. Ideally, the bees would maintain the ability to produce the suitable RNA for a long time (or permanently), but would express it only in case of infection is happening. In theory it should be possible to insert the RNA gene in the genome of the honeybees under very tight control. In practice, though, this would be extremely tough. But while the process of genetically engineering insects is not very practical, the technology to modify bacteria is quite mature.

Bees, as every organism, have a rich microbiome. It should be possible modify one of these microbes to deliver the RNA cure to its bee hosts. This is exactly the idea researchers from the University of Texas explored in a recent article published in Science. Sean Leonard and his collaborators genetically modified the bacterium Snodgrassella alvi wkB2, one of the most abundant microbes found in the honeybee gut, to continuously deliver double stranded RNA.

The researchers first verified that engineered bacteria can establish themselves in the bees gut. They tested whether the modified S. alvi can deliver RNA to their host, and if this RNA can stimulate an RNAi response. As these early experiments were positive, the scientists tried to use the new probiotic to treat deformed wing virus and Varroa mite infections. Their results showed that the administration of the engineered microbe improved survivability, while the microbe by itself didnt seem to harm healthy bees.

This work from Leonard and the rest of the University of Texas team is an encouraging proof of principle. Their study shows that bee probiotics can confer parasite and virus resistance for several days to individual bees, though they dont show yet if such a treatment will work well on a hive level. Such an approach has the potential to be a versatile and generalized cure: the beekeepers could store and administer specialized probiotics for any possible outbreak. Bee probiotics would be very specific to the disease they teat and they would have minimal environmental impact (contained within the hives and disappearing over time).

Would honeybee probiotics get regulatory clearance? The question is a bit complicated. In the US, they would likely be regulated in same way as engineered human probiotics, which are already on the market. But the honey produced by treated bees and the pollinated crops are in regulatory uncharted territory, so nothing is assured as this issue is more ideological than science-based. The food products are definitely not GMOs as the bee or crop DNA would not be affected but regulators might nonetheless under political pressure to require proof about environmental and food safety, even though there is no logical scientific basis for requiring such information as there would be no detectable difference in honey derived from such bees. Most probably, countries with tougher GMO restrictions (such as in the EU) will be as skeptical of probiotics from RNA-modified bees as they are of other genetic engineering technology, and are unlikely to approve them.

Insects are organisms with immense financial, ecological, and social importance. Synthetic biology may provide ways to protect or control insect populations without the use of harmful chemicals, destroying habitats, or introducing invasive species ways that we currently employ with well-documented consequences. Engineering the microbiome is a way to solve biological problems by bypassing the hurdles of transforming complex multicellular organisms, a back door to make synthetic biology easier. And the honeybee back door is now pried open.

Kostas Vavitsas, PhD, is a Senior Research Associate at the University of Athens, Greece. He is also a steering committee member of EUSynBioS. Follow him on Twitter @konvavitsas

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Disease is the greatest threat to bee health. Can we protect them through genetically engineered probiotics? - Genetic Literacy Project

CSL Behring and SAB Biotherapeutics Join Forces to Deliver New Potential COVID-19 Therapeutic – P&T Community

KING OF PRUSSIA, Pa. and SIOUX FALLS, S.D., April 8, 2020 /PRNewswire/ --Global biotherapeutics leader, CSL Behringand innovative human antibody development company SAB Biotherapeutics(SAB) announced today their partnership to combat the coronavirus pandemic with the rapid development of SAB-185, a COVID-19 therapeutic candidate on track for clinical evaluation by early summer. The partnership joins the forces of CSL Behring's leading protein science capabilities with SAB's novel immunotherapy platform capable of rapidly developing and producing natural, highly-targeted, high-potency, fully human polyclonal antibodies without the need for blood plasma donations from recovered patients.

The therapeutic candidate, SAB-185, is generated from SAB's proprietary DiversitAb platform producing large volumes of human polyclonal antibodies targeted specifically to SARS-CoV-2, the virus that causes COVID-19. Driven by advanced genetic engineering and antibody science, SAB's novel approach, leveraging genetically engineered cattle to produce fully human antibodies, enables a scalable and reliable production of targeted, higher potency neutralizing antibody product than has been previously possible. SAB's approach has expedited the rapid development of a novel immunotherapy for COVID-19 deploying the same natural immune response to fight the disease as recovered patients, but with a much higher concentration of targeted antibodies.

"COVID-19 is a nearly unprecedented public health crisis," said CSL Behring's Executive Vice President and Head of R&D Bill Mezzanotte, M.D. "That's why we're combining our leading capabilities in plasma product development and immunology with external collaborators to help find multiple, rapid solutions. In the near-term, SAB Biotherapeutics' novel immunotherapy platform provides a new and innovative solution to rapidly respond without the need for human plasma adding a different dimension to the industry-wide plasma-derived hyperimmune alliance effort we recently launched for the COVID-19 crisis. For future pandemics, SAB's platform may allow us to even more rapidly respond to patients' needs."

"Our targeted high-potency immunotherapies leverage the native immune response thereby providing a highly-specific match against the complexity, diversity and mutation of a disease," said Eddie J. Sullivan, PhD, SAB Biotherapeutics president, CEO and co-founder. "Our partnership with CSL Behring shifts our development trajectory to more rapidly scale-up and delivery of our highly targeted and potent COVID-19 therapeutic candidate, and deploy our unique capabilities to help combat this crisis. We have a successful preclinical track record for addressing infectious disease targets including Ebola, MERS, and SARS with our proprietary platform and appreciate that this collaboration with a global biopharmaceutical powerhouse will magnify the potential impact of a COVID-19 immunotherapy and provide an important framework for establishing sustainable solutions for the future."

CSL Behring has provided seed funding to offset some initial development costs that were funded by SAB in good faith, responding to the global pandemic as quickly as possible. SAB has already secured approximately $7.2 million in funding through an interagency agreement with the Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (JPEO - CBRND) and Biomedical Advanced Research and Development Authority (BARDA)to support SAB to complete manufacturing and preclinical studies. CSL Behring will then commit its clinical, regulatory, manufacturing and supply chain expertise and resources to deliver the therapeutic to the market as soon as possible, on terms to be agreed with SAB.

Earlier this year, the companies announceda collaboration to investigate SAB's platform technology as a new source for human immunoglobulin G (IgG) and the potential for new therapies to treat challenging autoimmune, infectious and idiopathic diseases by leveraging SAB's DiversitAb platform.

About CSL Behring CSL Behring is a global biotherapeutics leader driven by its promise to save lives. Focused on serving patients' needs by using the latest technologies, we develop and deliver innovative therapies that are used to treat coagulation disorders, primary immune deficiencies, hereditary angioedema, inherited respiratory disease, and neurological disorders. The company's products are also used in cardiac surgery, burn treatment and to prevent hemolytic disease of the newborn. CSL Behring operates one of the world's largest plasma collection networks, CSL Plasma. The parent company, CSL Limited (ASX:CSL;USOTC:CSLLY), headquartered in Melbourne, Australia, employs more than 26,000 people, and delivers its life-saving therapies to people in more than 70 countries. For more information, visit http://www.cslbehring.com and for inspiring stories about the promise of biotechnology, visit Vita http://www.cslbehring.com/Vita

About SAB Biotherapeutics, Inc.SAB Biotherapeutics, Inc. (SAB), headquartered in Sioux Falls, S.D. is a clinical-stage, biopharmaceutical development company advancing a new class of immunotherapies leveraging fully human polyclonal antibodies. Utilizing some of the most complex genetic engineering and antibody science in the world, SAB has developed the only platform that can rapidly produce natural, highly targeted, high-potency, immunotherapies at commercial scale. The company is advancing programs in autoimmunity, infectious diseases, inflammation and exploratory oncology. SAB is rapidly progressing on a new therapeutic for COVID-19, SAB-185, a fully human polyclonal antibodies targeted to SARS-CoV-2 without using human donors. SAB-185 is expected to be ready for evaluation as early as summer 2020. The company was also recently awarded a $27 million contract from the U.S. Department of Defense (DoD) to leverage its unique capabilities as part of a Rapid Response Antibody Program, valued at up to $27 million. For more information visit: http://www.sabbiotherapeutics.com.

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CSL Behring and SAB Biotherapeutics Join Forces to Deliver New Potential COVID-19 Therapeutic - P&T Community

CAR T-Cell Therapy for Multiple Myeloma – Global Market Insights and Market Forecast to 2030 – ResearchAndMarkets.com – Yahoo Finance

The "CAR T-Cell Therapy for Multiple Myeloma - Market Insights and Market Forecast - 2030" report has been added to ResearchAndMarkets.com's offering.

This report delivers an in-depth understanding of the CAR T-Cell Therapy use for Multiple Myeloma as well as the CAR T-Cell Therapy market trends for Multiple Myeloma in the 6MM i.e., United States and EU5 (Germany, Spain, Italy, France and the United Kingdom).

The Multiple Myeloma CAR T-Cell Therapy market report provides current treatment practices, emerging drugs, CAR T-Cell Therapy market share of the various CAR T-Cell Therapies for Multiple Myeloma, the individual therapies, current and forecasted Multiple Myeloma CAR T-Cell Therapy market Size from 2017 to 2030 segmented by seven major markets. The Report also covers current Multiple Myeloma treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate best of the opportunities and assesses underlying potential of the market.

Reasons to Buy

Report Highlights

Key Topics Covered:

1. Key Insights

2. Executive Summary

3. CAR T-Cell Therapy Market Overview at a Glance

3.1 Market Share (%) Distribution of CAR T-Cell Therapy for MM in 2030

4. CAR T-Cell Therapy Background and Overview

4.1 Introduction

4.1.1 CARs Generations

4.1.2 Genetic Engineering of T-Cells

4.1.3 How CAR T-Cell Therapy Works

4.2 The promise of CAR T-cell targeting B cell maturation antigen (BCMA) in multiple myeloma

4.3 Current challenges in CAR T

4.3.1 Therapeutic side effects

4.3.2 CAR T-cells lack of success

4.4 CAR T-cell therapy: Route to reimbursement

4.5 Unmet needs

5. CAR T-Cell Therapy for Multiple Myeloma (MM): 6 Major Market Analysis

5.1 Key Findings

5.2 Market Size of CAR T-Cell Therapy in 6MM

5.2.1 Market Size of CAR T-Cell Therapy by Therapies

6. Market Outlook

7. Emerging Drug Profiles for Multiple Myeloma

7.1 bb2121: Celgene Corporation

7.1.1 Product Description

7.1.2 Research and Development

7.1.3 Product Development Activities

7.2 JNJ-68284528 (LCAR-B38M): Janssen Research & Development

7.2.1 Product Description

7.2.2 Research and Development

7.2.3 Product Development Activities

7.3 P-BCMA-101: Poseida Therapeutics

7.3.1 Product Description:

7.3.2 Research and Development

7.3.3 Product Development Activities

7.4 CAR-CD44v6: MolMed S.p.A.

7.4.1 Product Description

7.4.2 Research and Development

7.4.3 Product Development Activities

7.5 JCARH125 (Orvacabtagene autoleucel): Celgene Corporation

7.5.1 Product Description

7.5.2 Research and Development

7.5.3 Product Development Activities

7.6 Descartes-08: Cartesian Therapeutics

7.6.1 Product Description

7.6.2 Research and Development

7.7 CT053 : CARsgen Therapeutics)

7.7.1 Product Description

7.7.2 Research and Development

7.7.3 Product Development Activities

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/auj3ij

View source version on businesswire.com: https://www.businesswire.com/news/home/20200409005373/en/

Contacts

ResearchAndMarkets.comLaura Wood, Senior Press Managerpress@researchandmarkets.com For E.S.T Office Hours Call 1-917-300-0470For U.S./CAN Toll Free Call 1-800-526-8630For GMT Office Hours Call +353-1-416-8900

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CAR T-Cell Therapy for Multiple Myeloma - Global Market Insights and Market Forecast to 2030 - ResearchAndMarkets.com - Yahoo Finance

Tension Builds Over Drug To Treat COVID-19 – caribbeannationalweekly.com

MIAMI, Florida With coronavirus (COVID-19) cases increasingdramatically in the United Statessome 435,000 cases as of Thursdaythe nation now has the most cases globally and is desperate for a drug to effectively treat the virus.

Unlike other forms of coronavirus, like the common cold and influenza, there is yet no proven medication to treat COVID-19. The possibility of a vaccine to treat the virus is at least a year away, according to most scientists best estimates.

In recent weeks, there have been claims, including from President Donald Trump and members of his administration, that a drug, hydroxychloroquine, normally used to treat malaria and lupus, is effective in treating COVID-19.

Two weeks ago, Trump at one of his coronavirus task-force press conferences, optimistically said the drug has potential as a drug to treat COVID-19. However, at the same press conference the top U.S. infectious disease expert, Dr. Anthony Fauci, while agreeing that the drug could have a positive effect with COVID-19 patients, cautioned that it needed to be tested before it can be generally prescribed for coronavirus.

Last Sunday at another coronavirus task-force press conference, President Trump again touted the use of hydroxychloroquine to treat COVID-19 although testing of the drug hasnt been completed.

What do I know, Im not a doctor, Trump said Sunday. But I have common sense. In promoting the use of the drug, the president has often stated, What have you got to lose?

One of the Trump administrations strongest backersof the drug is Trade Adviser Peter Navarro, who according to reports that surfaced after Sundays press conference, clashed with Dr. Fauci over the use of the drug. Dr. Fauci continuesto be concerned about recommending the drug based only on unscientific, or as he puts it anecdotalevidence.

Navarro, on the other hand, despite not having formal medical training, claimed in a CNN interview on Monday that reports of studies on the drugs use, which he had collected, were enough to recommend the drug widely.

The American Medical Associations president, Dr. Patrice Harris, also said she wouldnt prescribe the drug for coronavirus patients, because the risks of severe side effects were great and too significant to downplay without large studies showing the drug is safe and effective for such use.

Nonetheless, some doctors are actually prescribing Hydroxychloroquine to patients with COVID-19. Research studies are now beginning to test if the drugs truly help COVID-19 patients, and the Food and Drug Administration has allowed the medication as an option for doctors to consider for patients who cannot get into one of these studies.

Dr. Harris and other doctors claim the drug has serious side effects, especially affecting the heart rhythm, and still want more testing conducted before its clear that the drug works against the virus and where the side effects are concerned.

Cubas Interferon Alpha 2B

Meanwhile, a drug developed in Cuba has been proving to have positive results in treating COVID-19 patients. The drug, Interferon Alpha 2B, is among 22 drugs developed in Cuba since 1986 by its Center for Genetic Engineering and Biotechnology (CIGB) and used as a treatment for HIV-AIDS, hepatitis B and C, herpes zoster or shingles, dengue and different types of cancers.

It is also highly recommended by medical specialists for its ability to fight the COVID-19 virus. During the onset of the virus in Wuhan province, the Chinese authorities found it exceptional in destroying the virus from thousands of its citizens who contracted the disease at the earliest stages.

Since the success of this antiviral drug has become public knowledge, Cuba has been flooded with requests from across the globe, including, Africa, Europe, Latin, and South America and Caribbean nations.

Evidence tuberculosis vaccine BCG prevents COVID-19 infection

Recently reports surfaced that the BCG vaccine given to counter tuberculosis (TB) may provide protection against COVID-19 and significantly reduce death rates in countries, including most Caribbean countries,with high levels of this vaccination.

A study of 178 countries conducted by an Irish medical consultant in conjunction with epidemiologists at the University of Texas indicated countries with BCG vaccination programs have far fewer coronavirus cases by a factor 10, compared to countries without such programs.

The BCG vaccine is still widely used in developing countries, where scientists have found, along with preventing TB, it alsoprevents infant deaths from a variety of causes, and sharply reduces the incidence of respiratory infections like the coronavirus.

Most Caribbean-Americans residing in South Florida bearthe scars of the BCG vaccine on their upper arms, as the vaccine was and still is mandatory for attending public schools in the Caribbean.

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Tension Builds Over Drug To Treat COVID-19 - caribbeannationalweekly.com

One in four Britons ‘think the coronavirus was probably created in a lab’ – Yahoo Sports

One in four Britons think the coronavirus was probably created in a lab, research suggests.

Scientists from Kings College London asked more than 2,000 people what they believed to be true about the somewhat mysterious strain.

A quarter (25%) of those surveyed thought the coronavirus is probably man-made, a conspiracy theory circulating the internet.

Early research suggests the infection is mild in four out of five cases, however, it can trigger a respiratory disease called COVID-19.

A member of staff gives directions at a coronavirus testing centre for NHS staff at an IKEA in Gateshead, Tyne and Wear. (Getty Images)

The Kings scientists surveyed 2,250 people aged between 18 and 75.

Of the participants who thought the coronavirus was probably created in a lab, 12% admitted to meeting up with friends during the UKs lockdown.

This is more than double the 5% of participants who socialised with loved ones, but were convinced of the strains natural origin.

Latest coronavirus news, updates and advice

Live: Follow all the latest updates from the UK and around the world

Fact-checker: The number of COVID-19 cases in your local area

Explained: Symptoms, latest advice and how it compares to the flu

Boris Johnson has enforced draconian measures that only allow Britons to leave their home for very limited purposes, like exercising or shopping for essentials.

The prime minister, who is in intensive care with coronavirus complications, has repeatedly stressed people are not to socialise with those outside of their home.

Nearly a quarter (24%) of the Kings participants who believed the coronavirus was probably manufactured thought too much of a fuss is being made about the pandemic.

This is compared to one in 10 (10%) of those who believed the strain is natural.

Emerging at the end of last year, only the relatively small number of people worldwide who have encountered the virus are thought to have immunity against it.

The race is on to develop a vaccine that will enable herd immunity, allowing the public to safely go back to their normal routine.

The survey participants who thought a jab will be available within three months were nearly four times as likely to have met up with friends during the lockdown than those of the opinion a vaccine will take longer.

Numerous pharmaceutical companies around the world are working to develop a jab, however, scientists have been upfront one will not be ready for this outbreak.

A vaccine may become available, however, if the infection turns out to be seasonal.

People have generally got the message about how serious the threat from the virus is and the importance of the measures being required of them, said study author Professor Bobby Duffy.

But at a time when the government is warning it may bring in more severe restrictions if enough people dont follow the rules, this research shows there is a significant minority who are unclear on what some of them are, as well as many who still misjudge the scale of the threat from coronavirus or believe false claims about it.

And this matters how we see current realities and the future is often related to how we strictly we follow the guidelines and our attitudes to the lockdown measures.

A man wears a mask outside a closed electrical-goods shop in the centre of Munich. (Getty Images)

Story continues

The coronavirus is thought to have emerged at a seafood and live animal market in the Chinese city Wuhan, capital of Hubei province, at the end of 2019.

The market is said to have sold a range of dead and alive animals, including bats, donkeys, poultry and hedgehogs.

Most of those who initially became unwell at the start of the outbreak worked at, or visited, the Wuhan market.

This has led scientists to believe the new coronavirus jumped from an animal into a human while the two were in close contact.

The coronavirus is one of seven strains of a class of viruses that are known to infect humans.

Another strain is severe acute respiratory syndrome (Sars), which killed 774 people during its 2002/3 outbreak.

Sars is thought to have started in bats and jumped into humans via masked palm civets.

Research suggests the new coronavirus shares more than 96% of its DNA with a strain detected in horseshoe bats and may have reached humans via pangolins.

Despite the evidence, conspiracy theories have arisen suggesting the strain could have been engineered.

To debunk this, scientists from Scripps Research in San Diego analysed the DNA of the virus and others like it.

They specifically looked at proteins on the surface of the viruses that allow them to enter human cells.

Results suggested the coronavirus evolved to target a receptor on human cells called ACE2.

This targeting is so effective, the scientists concluded it was the result of natural selection and not genetic engineering.

The coronavirus genetic backbone is also distinct from other pathogens. The scientists argued if one were to manufacture a disease, they would work off a backbone that is known to cause ill health.

By comparing the available genome sequence data for known coronavirus strains, we can firmly determine that [the new strain] originated through natural processes, said study author Dr Kristian Andersen.

A woman wears a mask while walking dogs in Palma, Spain. (Getty Images)

Since the coronavirus outbreak was identified, more than 1.5 million cases have been confirmed worldwide,according to Johns Hopkins University.

Of these cases, over 339,700 are known to have recovered.

Globally, the death toll has exceeded 89,900.

The coronavirus mainly spreads face-to-face via infected droplets expelled in a cough and sneeze.

There is also evidenceit may be transmitted in faecesandcan survive on surfaces.

Although most cases are mild, pneumonia can come about if the coronavirus spreads to the air sacs in the lungs.

This causes them to become inflamed and filled with fluid or pus.

The lungs then struggle to draw in air, resulting in reduced oxygen in the bloodstream and a build-up of carbon dioxide.

The coronavirus has no set treatment, with most patients naturally fighting off the infection.

Those requiring hospitalisation are given supportive care, like ventilation, while their immune system gets to work.

Officials urge people ward off the coronavirus bywashing their hands regularlyand maintainingsocial distancing.

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One in four Britons 'think the coronavirus was probably created in a lab' - Yahoo Sports

Fear of global plagues and greed for money are as old as mankind – SowetanLIVE

Most of us have been taught to understand the word "historian" to refer to a specialist who writes about the past.

One of the greatest - if not the greatest - historians alive today is a 44-year-old man by the name of Yuval Harari, currently lecturing at the Hebrew University of Jerusalem, Israel.

Five years ago, Harari changed the meaning of "history" by publishing a book about the future - Homo Deus: A Brief History of Tomorrow.

The title of this prophetic book is pregnant with meaning. It combines two beings - earthly and divine - to produce an omnipotent hybrid called "Domo Deus".

In palaeontology, the prefix "homo" refers to creatures that evolved into the human family. In classical Latin, "Deus" meant "god". Thus, Harari's book envisions a future where man can appropriate the powers of "god", and therefore become a human-god or "Homo Deus".

In the first chapter, Harari writes about the "anti-death" scientific research under way at the well-known American company Google.

In 2009, one of the leading anti-death researchers at Google, Bill Maris, fervently believed it would be possible, through genetic engineering, for a human being to live until he is 500 years old.

That idea rests on a fundamental transformation of the meaning of "death" that has taken place in the mind of man - from the understanding of death as a mysterious occurrence preordained by a deity to death understood as, according to Harari, "a technical problem that we can and should solve".

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Fear of global plagues and greed for money are as old as mankind - SowetanLIVE

[Commentary] In the post-COVID world, health security must be a matter of national security – Mongabay-India

The Chinese New Year is a time to visit families and ancestral lands. It began with the Little Year (January 17 to 24), followed by the main Spring Festival (January 25 to February 4), and ended with the Lantern Festival (February 5 to 8).

As people were getting ready to travel in December 2019, pneumonia cases started showing up in hospitals across the Hubei Province of central China, especially in Wuhan, Chinas ninth most populous city with about 11 million people about the size of Bengaluru. Both Bengaluru and Wuhan are also denoted as Beta level cities by the Globalization and World Research Cities Network (GaWC), a think tank that charts the relationships of world cities to globalization. Both are cities that link moderate economic regions to the world economy.

But let us go back in time to when people were possibly making their New Year travel bookings, a new virus was jumping from bats into humans either directly or through an intermediate animal host. Its spread in the human population timed perfectly with the New Year travel season, which spread it, first in China and then elsewhere.

Going back further to March 2019, researchers in Wuhan and Beijing, who were studying viruses in batswrotealmost prophetically in the journalViruses:it is highly likely that future SARS- or MERS-like coronavirus outbreaks will originate from bats, and there is an increased probability that this will occur in China.

And even before that in 2018, researchers had discovered two novel coronaviruses from bats in eastern China that looked very similar to the Severe Acute Respiratory Syndrome (SARS) coronavirus that emerged in China in December 2002 and then disappeared by mid-2003, leaving about 8000 people infected and 774 dead.

Coronaviruses belong to a family of viruses that infect animals and humans, are distinguished by their crown-like (corona) appearance under a microscope, and cause a flu-like disease. Besides SARS-CoV, the family included the Middle East Respiratory Syndrome (MERS) virus and at least four other viruses endemic in the human population.

The 2019 novel coronavirus (2019-nCoV), later renamed SARS coronavirus 2 (SARS-CoV-2) due to its genetic similarity with the SARS virus, was established as the cause of a new disease called coronavirus infectious disease 2019, or COVID-19.

The World Health Organization (WHO) has declared COVID-19 to be a pandemic.As ofApril 7 2020, there are over 1.4 million confirmed cases and 80,000 deaths attributed to it in 184 countries. The pandemic is still growing in USA, Europe and other parts of the world, leaving the global economy, markets and supply chains in disarray.

The year 2020 is the Chinese Year of the Rat. It will be long remembered as the Year of the Bat.

As of April 8, 2020, India is early on the COVID-19 curve with about 4643 confirmed casesand 149 deaths; a 21-day nationwide lockdown is in place till April 14. There are no clear estimates on the scale of the impending outbreak, but all models point to tens of lakhs to crores of infections in India. Simulations on lockdown suggest repeats at national, state and regional levels. These would have to balance public health needs against the economic and humanitarian crisis, which has left so many without food, shelter and security.

A KPMG Indiareport Potential Impact of COVID-19 on the Indian Economy, says COVID-19 is unique in that it is a supply, demand and market shock. It further adds that the outbreak has disrupted manufacturing supply chains and sharply curtailed energy and commodity demand. China is Indias second-largest trading partner, with total trade pegged at $92.68 Bn, which includes $74.72 Bn in imports and $17.95 Bn in exports. This amounts to 13.7% of Indias total imports and 5.1% of its exports.

Also read: It is not COVID-19 alone, but also the environment and the economy

Though COVID-19 is a significant challenge, it also presents an opportunity. How must India prepare itself for the post-COVID world? My central argument is that India must start addressing health security as a matter of national security. It must build local capacity to reduce its dependence on imports and supply chains. It must also invest in public health preparedness and health research.

With the disruption in China, the most vulnerable sectors for India are electronics and pharmaceuticals, both of which impact our critical healthcare sector. India imported over 70% of its bulk drugs and their active pharmaceutical ingredients (APIs), amounting to $2.4 Bn, from China in 2018-19. Though this problem was highlighted by the National Security Advisor in November 2014, the continued dependence on China is worrisome, especially with a looming health crisis. In February this year, the government put together a list of 38 drug raw materials that it wantslocally produced, including fermentation process-based ingredients for antibiotics, vitamins and hormone drugs. It would also be important to address bottlenecks such as environmental clearances and tax concessions for the local industry.

India must also increase its allocation to healthcare and focus on public health. The FY 20-21 budget allocation for health is Rs. 69,000 crores, a public spending of 1.6% of GDP, even after the National Health Policy 2017 called for an increase to 2.5% of GDP. According to WHO, India ranks 184 out of 191 countries on its public spending on healthcare as a percent of GDP. Contrast this to Indias military spending pegged at Rs. 471,378 crores, almost seven times its health budget.

TheAyushman BharatPM Jan Arogya Yojana(AB-PMJAY) scheme to provide free healthcare to 10 crores families (50 crore people) is a promising addition, but disappointments include drastic cuts to the health insurance scheme (Rashtriya Swasthya Bima Yojana) and no increase for communicable diseases. The National Rural Health Mission (NRHM), which includes many health schemes, also received marginally less than last year.

India is projected to be a hotspot for zoonotic, vector-borne and drug-resistant infections. With over 1.3 Bn people, 536 Mn livestock and 851 Mn poultry, it has the worlds highest density of each, and is thus a ripe ecosystem for pathogen exchange. There are 117 species of bats in India, but what viral secrets they hold remain unknown. A recent study by the National Centre for Biological Sciences, Bengaluru to start addressing this remains mired in controversy.

Our lessons from COVID-19 should be to strengthen the public health infrastructure, invest in One Health science to understand the animal-human disease interface and modernize our approach to R&D. An independent National Centre for Pathogen Research, with a broad mandate for inter-disciplinary work from pathogen discovery to characterization and product development is needed for India. This may work in close partnership with organizations such as the Indian Council of Medical Research (ICMR) and the National Centre for Disease Control (NCDC), which have developed core expertise in outbreak investigation and diagnostics.

The 2002 SARS outbreak is estimated to have caused global economic losses of $40 Bn. For COVID-19, the UNs trade and development agency UNCTAD puts notional losses at $1 Trillion. There are an estimated 631,000 to 827,000 yet-to-be-discovered viruses in animal reservoirs with zoonotic potential. The Global Virome Project aims to expand virus discovery to reduce their future impact on human populations, but their biggest challenge is the cost estimated to be $1.2 Bn.

Would this not be a sensible investment to make in the post-COVID world?

[Shahid Jameel, Ph.D., was Head, Virology Group at the International Centre for Genetic Engineering and Biotechnology, New Delhi. He is now CEO of the DBT/Wellcome Trust India Alliance].

Related: [Interview] Taking One Health approach to tackle zoonoses crucial for India

Banner image:A typically crowded marketplace in India before the COVID-19 pandemic struck. Photo from Unsplash.

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[Commentary] In the post-COVID world, health security must be a matter of national security - Mongabay-India

Why Americans of All Ages Are Embracing Communal Living – Time

Everyone Needs Someone Else

WHY Americans OF ALL AGES are coming together in intentional communities

By Jeffrey Kluger

Theres not a lot to do in Syracuse, N.Y. when youre living alone and a winter storm system dumps 3 feet of snow on the city. Theres no going outside, but theres no staying inside at least not for too long if you want to remain sane. A dinner with friends would be nice; so would a yoga class or a shared movie and a good long talk. And when thats all done, it would also be nice to have just a little bit of that wintertime solitude, watching the snow fall, all alone, from the privacy of your own home.

At one place in Syracuse, all of that happens on those long snow-filled nights. That place is Commonspace, a co-housing community on the fourth and fifth floors of a restored 19th-century office building. The community is made up of 25 mini-apartments, fully equipped with their own kitchenettes and baths, with access to a larger, shared chefs kitchen, library nook, game room, coffee lounge and media room. The 27 residents (couples are welcome) live together but only sort of in private apartments that are, once you step outside your door, un-private too. And theyre part of a growing trend in an increasingly lonely country: intentional communities.

In cities and towns across the U.S., individuals and families are coming to the conclusion that while the commune experiment of the 1960s was overwhelmed by problems, the idea of living in close but not too close cooperation with other people has a lot of appeal. An intentional community is a very different beast from the more familiar planned communities, which can be big, unwieldy things hundreds or thousands of families living on small parcels across hundreds of acres of land. While there may be some common facilities a swimming pool or golf course or community lake the communities are really just villages writ large or cities writ small, easy places to be anonymous.

Intentional communities, by contrast, are intimate: a couple dozen apartments or single-family homes, built around central squares or common spaces. And theyre operated in ways intended to keep the community connected with weekly dinners at a community center or other common area, shared babysitting services, shared gardens or games or even vacations. If you dont want to participate, fine; no one will come pester you to play a pick-up game you dont want to play or join a committee you dont want to join. But when you need the community because a spouse is away or a baby is sick or youre just plain lonely and would like some companionship its there for you.

Its that business of relieving loneliness thats key to the popularity of intentional communities. Human beings may not always get along, but the fact is, we cant get enough of one another. There are currently 7.6 billion of us in the world but we inhabit only about 10% of the planets land, and roughly 50% of us live on just 1% of that land.

We evolved to depend on our social connections, says Dr. Vivek Murthy, former U.S. Surgeon General. Over thousands of years, this got baked into our nervous systems so much so that if we are feeling socially disconnected, that places us in a physiologic stress state.

According to a study by AARP, over 40% of American adults suffer from loneliness, a condition that, Murthy warns, is as dangerous to our physical health as smoking 15 cigarettes a day, increasing the risk of cardiovascular disease, diabetes, cancer and more. Worse, loneliness is a condition that makes no demographic distinctions; it affects millennials just starting their careers, widowed boomers just ending theirs, empty-nesters, new divorcees, first year college students a thousand miles away from family and high school friends. Social media, which ostensibly draws people closer, in fact may be atomizing us further, creating virtual connections that have little of the benefits of actual connections.

A gusher of studies since the early 1990s have established the health dividends of social ties. Among people with cardiovascular disease, those with more social connections have a 2.4 times lower risk of mortality within an established period than those with poor social ties. Social connections lower the risk of cancer, speed recovery among people who do contract the disease, and reduce the risk of hypertension and other cardiovascular illnesses. Even wound-healing improves with social connections. Multiple studies suggest that part of this may come from the psychological boostincluding the sense of responsibilitythat meaningful relationships provide. When friends and family members are counting on you to be around, you make better health choices, even if theyre unconscious. Other studies have shown that similar brain structures control both physical pain and social painand that pain relief, through analgesics in the first case and relationships in the second, operate similarly as well. Being socially connected doesnt simply make you healthier, it just plain feels good.

Intentional communities are about creating attachment, the feeling that someone has your back, says Harvard University psychiatrist Robert Waldinger, director of the Harvard Study of Adult Development, a decades-old survey of the health of a population of Harvard graduates and their descendants. We often ask people in studies, Who would you call in the middle of the night if you were really sick or scared? Intentional communities can help you have an answer to that question.

Its not easy to come by a firm count of how many intentional communities are out there. Only about 160 of them have been built from the ground up with co-housing in mind, but the regularly updated Fellowship for Intentional Community lists 1,539 communities in all 50 states that have also used existing housing stock to establish co-housing arrangements.

There are urban communities like Commonspace in most major cities. There is Milagro in Tucson, Ariz., 28 single-family homes on 43 desert acres built around a central green space with a shared community center and other facilities. There is Village Hearth Co-Housing, a similar set-up in Durham, N.C., but one intended for singles, couples and families in the LGBTQ community. There are other communities for seniors or artists or veterans; there are even rural communities for people who want the independence of owning their own homes but the collective experience of farming the same land.

For each of the communities, the relative compactness of the population is what creates the feeling of togetherness. You cant possibly know three hundred people, says Troy Evans, real estate developer and the co-founder of Syracuses Commonspace. But you can know fifty. What we try to do in Commonspace is create a neighborhood in a building.

To all appearance, theyve succeeded at that. The communitys 25 apartments rent for an average of $850 per month, which is admittedly pricey for a tiny, 200 sq. ft. space, though services like thrice-weekly cleaning of all of the common spaces and the costs of activities like the weekly farm-to-table dinners are included. And the social benefits which are impossible to measure in dollars and cents are included too.

We set everything up with a town square feel so when you come out of your door theres not a long, dark hallway like in most apartment buildings, says Evans. Town squares, of course, can be noisy not to the liking of even some people who choose to live semi-communally. Thats why one of the floors has fewer apartments built a quiet lounge where locally roasted coffee is always on offer.

The mini-apartments are cleverly laid out, with a platform bed built atop storage cabinets and floor-to-ceiling windows that create an open feel. The bathroom is complete though it has a shower without a tub and the kitchenette is limited only by the fact that is has two electric burners instead of a full stove, because local regulations forbid open flame in such small quarters. The apartments are all equipped with TVs and high-speed Internet, and a Slack channel allows residents to stay in touch without having to remember 26 other email addresses.

Still, its the 6,000 shared square feet, not the 200 private ones that really defines the Commonspace experience, providing what Evans describes as a lot of collision space, which is something people who would otherwise be living alone often crave. What weve found is demand from people who were landing in Syracuse for the first time and not knowing anyone, he says. Weve got people from eight different countries and seven different states. Its a really cool, diverse group.

That diversity is not only cultural but temperamental. Rose Bear Dont Walk, a 23-year old Native American studying environment and forestry at the State University of New York, Syracuse, moved in to Commonspace over the summer and soon grew friendly with another resident who works in computer coding. His mind operates arithmetically, hers works more emotively, and they took to talking about their different ways of approaching the world.

Hes always building something or talking about building something or listening to podcasts, she says. One day, when she was weaving decorative strands out of plant fibers, she decided to make him a bracelet. It was just this way that our worlds connected, she says. He is very logical and mathematical and was very excited about this little tiny rope bracelet that I was bringing home.

Meaningful as those kinds of connections can be, Commonspace residents dont always have a lot of time to make them. Millennials can be transitory characteristic of most people early in their careers and the average length of tenancy is just eight months.

Things are very different at other intentional communities, like Milagro in Tucson. There, the buy-in is typically for life. The 28 homes in the landscaped desert space are sometimes available for rent, but are typically owned by their residents and have sold for anywhere from $175,000 to $430,000, depending on the market. The investment in house and land means an equal investment in the life of the community.

Brian Stark, a married father of two, has lived in Milagro since 2003, two years after the community opened, and considers himself a lifer. For him the appeal is not so much the community-wide dinner in the dining room every Saturday, or the happy hours or the stargazing sessions or the shared holiday parties. Its the easy, collegial pace of the place, unavoidable when neighbors all know one another.

You almost have to assume that someone may stop to chat with you when youre coming or going, he says. It took some getting used to but when were in a hurry for school or a meeting, weve learned to explain our rush and connect another time.

Even more important are the benefits that accrue to any communitys most vulnerable members: babies and seniors. For families with very young children, we do baby care trades, Stark says. And having a supportive community to help as you grow older is also a wonderful alternative to assisted care living.

Intentional communities are not without stressors. Stark recalls the decade of committee meetings that went into the simple business of deciding whether there should be path lights in the community important for safety, but murder on the deserts spectacular nighttime sky. Even when the community agreed that lights were a good idea, there was continued wrangling over cost, wattage and more. A similar struggle ensued when it came time to have all 28 homes painted, as residents debated color schemes for the homes stucco, trim and side boards.

Still, the long meetings and compromises are a small price for those suited to intentional communities. Thats true of diverse, cross-generational communities like Milagro, and it can be even more so when residents come together with a particular shared need for a particular kind of solidarity as in the LGBTQ or aging Boomer communities.

Shortly after the opening of Village Hearth, the North Carolina LGBTQ community, one of the founders explained to a local reporter that she was tired of hearing about this or that intentional community that has a nice lesbian couple or a nice gay couple. She and her wife didnt want to be a curiosity in even the friendliest surroundings, so they founded a community in which nothing would be remarkable about them at all.

There is little science so far that explicitly addresses the medical benefits of co-housing arrangements, but the benefits of the human connections the communities provide are being powerfully established. In one recent meta-analysis of 148 studies gathered from around the world, Julianne Holt-Lunstad, a professor of psychology and neuroscience at Brigham Young University, compared subjects reported state of loneliness with their overall life expectancy. The total sample size was more than 300,000 people and produced sobering results: Adults who are socially isolated, she found, have a 50% greater risk of dying from any cause within a given time frame than people who are more connected.

In a follow-up study in which she used census data to assemble an even larger sample group of 3.4 million, the results were a bit less stark, but no less conclusive, with social isolation and loneliness leading to a 30% increase in risk of mortality on average. Of course, being alone is not the same as being lonely, Holt-Lunstad stresses. Many people enjoy their solitude, and other people can feel lonely even in a group. The key is the subjective experience. If that experience is bad, thats when health can be affected.

More often than not, social media falls into the category of bad rather than good experiences. Even without being trolled or cyberbullied, people can suffer merely as a result of having replaced real relationships with virtual ones. Murthy does not believe social media is all bad, provided its often used as what he calls a way station rather than a destination, helping to establish real-life connections.

Using social media as a way station might mean that if Im traveling to a different city, in advance of the trip I look on Facebook or LinkedIn to see if I have any friends there, he says. Then I reach out to them and we get together.

The exact mechanisms that make loneliness so physically damaging are not easy to tease out, but chemical markers in the bloodstream, like cortisol, a stress hormone, or c-reactive proteins, indicators of inflammation, are considered worrisome signs. They indicate a weakened immune system and metabolic disruption, says Waldinger. This is when you start to see signs of illness like rising lipid levels and blood pressure.

Residents of intentional communities also see another kind of benefit to health and happiness in co-housing: as a way of alleviating transitions that can be both stressful isolating. Stark, the Milagro resident, recalls that when his older daughter, Maia, was born 12 years ago, the Milagro community was still new. Unbidden, the neighbors pitched in to help the family, cleaning their house, making them meals, even doing their laundry so that he and his wife could have the luxury of doing what few parents can do: focus their attention exclusively on their new baby. Since then, the Stark family has returned the favor, making food for people recovering from surgery and offering to make a pickup at an airport.

Everyone at some point needs someone else, Stark says. Intentional communities, in their quiet way, are helping to make sure that powerful human need gets met.

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Why Americans of All Ages Are Embracing Communal Living - Time

W&M community conversation turns to living, working adaptation amidst COVID-19 – William & Mary News

by Jennifer L. Williams | April 9, 2020

Now that the William & Mary community has seen that COVID-19 will affect many things this spring semester, adapting to living and working in the world it has created is next that was the takeaway from the universitys latest community conversation.

Ive described it as were all learning to ride a bicycle in a hurricane, said Peter Atwater '83, founder of Financial Insyghts and adjunct professor of economics, as he described the multiple roles students, faculty and staff have taken on with their many responsibilities at home.

W&M President Katherine A. Rowe led the virtual talk that was broadcast from the Presidents House on April 8 as part of a weekly series featuring different guests and discussion topics on Wednesdays at noon through May 13. She encouraged community members to continue to send questions to leadership as a way to guide future sessions.

Our focus now is on decisions about how we adapt, Rowe said. In the short term how we adapt, and in the longer term, in a way that sustains what we value most about this institution and about our community. So the big question that all of us are grappling with is how to make decisions about the best ways to adapt when our uncertainty is so high and very little seems to be in our own control.

So thats the question that is our focus for today. What happens to how both individuals and communities think when uncertainty is high and control is low?

Marjorie Thomas, dean of students; Eva Wong, director of international students, scholars & programs and Atwater were guests for the discussion.

Rowe summed up from many of their comments that looking out for each other, and giving ones self and others a break, particularly over the next couple of weeks, will be important.

Thomas said she has found solace in reaching out to others, in being more intentional and intimate in her time with other people.

Remember, we are still very much connected, that we still belong, Wong said. And try to find those connections one way or another.

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W&M community conversation turns to living, working adaptation amidst COVID-19 - William & Mary News

Guest column: In times of certainty, rely on all your communities – The Advocate

On Sunday Dec. 31, 2017, I stood before the people of the Star Hill Church and delivered my final sermon as their pastor. For 23 years of Sundays and Wednesdays, we had assumed our respective positions in a mutual search for meaning, purpose and wisdom.

A dear friend recently sent a text message asking what I would say to those precious people today. Ive dwelled on her question ever since and many other questions, too.

What do I say in the midst of such disruption and uncertainty? What words can calm hearts, minds and spirits that have been bombarded with alarm after heightened alarm? What would I say to bring some sense of stability to this cauldron of disequilibrium? What are the spiritual truths that can be applied to the COVID-19 world? What can I suggest people do when I dont know what to do?

These thoughts rode a carousel in my mind. Around and around they went until, in a moment similar to moments in the many weeks of my 23 years, my thoughts landed on an ancient episode.

Jehoshaphat was the fourth king of the Kingdom of Judah. He was zealous in his beliefs and has been generally well spoken of in the historical records. But there was an instance when the king found himself facing a challenge beyond any he had faced in his lifetime. He was under attack. Not only under attack, but facing a confederacy of surrounding nations, all aligned and ready to pounce at any moment. What do you do when you dont know what to do?

Yes, it is here in the book of 2 Chronicles that I would invite peoples to join me in mining for nuggets that can not only sustain us but steel our resolve in the face of this great challenge.

I would point out that Jehoshaphat was alarmed. So we begin with a license to acknowledge the sense of dread, fear and concern that seems to come and go within all of us. COVID-19 is a daunting adversary and we should feel alarm. Far from something being wrong with us, or the need to put forth some false bravado, we can name this thing inside of us without shame. And we can see that Jehoshaphats alarm was not paralyzing.

I would call peoples attention to Jehosaphats response to the military conflict. He chose to understand and react based on his spiritual beliefs. I would ask my anxious parishioners if they are informed by the whims of the national and local news, or by orthodoxy? Are they opening themselves to whatever bias or agenda is behind their chosen network? Or are they allowing their belief system to filter what is coming at them? Viewing our circumstances through the perspective of faith doesnt make them magically disappear or instantly get better. What it does is arm us with a framework with which to understand.

And one last thing. I would point out that Jehosaphat invited others in his community to join him in responding to his predicament. Adults, children and the older members of the community all came together in the face of adversity. They were, after all, in it together.

Just as we are all in this together. Now is not the time for heroic individualism. Withdrawal and isolation are actually part of the attack, not part of the answer. Our village, tribe, congregation, parish, neighborhood, family, friends and colleagues are all part of our arsenal in moments like these. We can create new ways of connecting, try video chats in addition to phone calls, and stand across the street as we engage neighbors. But above all else, we can be intentional in sustaining these relationships.

What should we do when we dont know what to do? Embrace these relationships. Make the most of them. Treasure them.

Raymond A. Jetson heads the Baton Rouge nonprofit MetroMorphosis.

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Guest column: In times of certainty, rely on all your communities - The Advocate

Lessons From Mutual Aid During the Coronavirus Crisis – Stanford Social Innovation Review

(Illustration by iStock/sv_sunny)

Amid a disaster like COVID-19, the culprits of some of the worst abuses of power are the very systems and structures that we often turn to for leadership. The abuses can be committed with calculated awareness, such as when US Senators privately sold off millions in stocks while publicly downplaying the threat of the virus. Other times, institutional aid efforts unintentionally create ripple effects that disproportionally and severely affect vulnerable communities. In the San Francisco Bay Area, for example, shelter-in-place policies and the curtailment of public services have devastated families with precarious employment and people without homes.

Whether harm differs by being intentional or structural, it is the same in one critical way: Top-down, centrally managed systems of power can end up creating havoc due to the lack of their understanding of local communities.

In my role as research director with Accountability Counsel, a nonprofit organization that protects communities' human and environmental rights around the globe, and in previous positions, I have witnessed numerous failures of top-down responses to crises. While coordinating international assistance into northern Syria at the Syrian-Turkish border for several years, I observed millions of dollars wasted on ineffective programming, and countless millions more spent on projects that led to increased violence, instability, and suffering for thousands of people. Compounding the problem, a lack of local knowledge and context prevented project designers from seeing the effects of their actions, and even the most destabilizing projects were continually renewed and expanded over time.

Our team at Accountability Counsel has seen the same dynamic play out in Myanmar, where top-down conservation efforts in response to a deforestation crisis have instead paved the way for further environmental exploitation, violated human rights, and threatened the fragile peace in a conflict zone. Without appropriate care and due diligenceand without proper consultation with impacted communitiesit is remarkably easy for a project designed to help people or the environment to instead result in untold harm.

That's just a couple of examples among many. Studies of disasters in New York, Argentina, and other locations have identified myriad ways that relief by outsiders canundermine the recovery it is intended to produce.

In the context of our current global crisis, community-led responses to COVID-19 have a clear advantage over those coming from distant centralized bastions of power, which, intentionally or not, often reflect and reinforce existing inequities.

Community organizations here in the San Francisco Bay Area, such as theArab Resource and Organizing Center (AROC), have provided invaluable support to vulnerable families who have been overlooked by official state responses, while tying their relief efforts to broader campaigns of mutual aid, collectivity, and solidarity. AROC explicitly uses its community support work to highlight the importance of health care as a right, anti-racism, climate change activism, and mutual solidarity for women, workers, migrants, incarcerated populations, people with disabilities, and the homeless. Accountability CounselsGood Ally policy aims to support civil society initiatives like AROC's. For example, our research team repurposed a community surveying tool to send SMS and voice messages to farmers across Haiti to help AROC identify vulnerable families in San Francisco.

It is important to remember that the vulnerabilities of these communities existed before the crisis cast them in such stark relief. With COVID-19 sharpening our awareness, we have an opportunity and responsibility to improve our social systems to better support society's most vulnerable not just during this crisis, but after it passes.

Many pathways toward a better world are being laid bare by the altruistic mutual aid efforts arising in cities around the globe. These locally designed and collaboratively built acts of solidaritywhich view the vulnerable as participants in their survival rather than passive consumers of assistanceinform a model of community resilience and collective empowerment with implications far beyond their immediate impact. They reject responses to the pandemic that value political hegemony and expediency over the well-being of the homeless, victims of domestic violence, people with disabilities and many other marginalized members of society.

The coronavirus pandemic has shaken the globe, and it is likely that things will never return to the way they once were.While we fight to mitigate the damage the crisis has wrought, we should learn lessons from the mutual solidarity and community resilience that it has unveiled. It will ensure the world that comes after the crisis is a better one for all.

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Lessons From Mutual Aid During the Coronavirus Crisis - Stanford Social Innovation Review

Communities of Color Must Be Centered in Gun Violence Prevention Movement – Juvenile Justice Information Exchange

Communities of color continue to be disproportionately impacted by gun violence across the United States. Unfortunately, communities that are most impacted by gun violence are often plagued by structural inequities that perpetuate this violence. That is why when we look to address gun violence, we must have a holistic conversation to ensure that those most impacted are being centered in this conversation and moved from the margins.

Lauren Footman

To have a holistic conversation, we must address root causes (such as poverty, income inequality, underperforming schools and under-resourced public services) while also advocating for equitable resources for community-based programs and addressing easy access to firearms. Moreover, once we are clear on the solutions, we have to keep the most impacted communities at the forefront of this conversation. This work heavily relies on data and the data shows us who is most impacted, so we must be intentional to prioritize the most impacted communities in our work when setting policy and programmatic agendas.

When discussing data and trends of gun violence, we cannot help but notice the ages of the victims. Data shows us that black youth both females and males are disproportionately impacted by gun violence. Our analysis of CDC data states Black boys and youths aged 0-19 were over 14 times more likely to be killed by firearm homicide than White (non-Latino) boys and youths, while Black men aged 20-34 were nearly 17 times more likely to be killed by firearm homicide than their White (non-Latino) counterparts. Black girls and youths aged 0-19 and Black women aged 20-34 were each nearly 6 times more likely to be killed by firearm homicide than their White (non-Latino) counterparts (5.92 and 5.63 times, respectively).

This data is sobering, but when you hear these stories firsthand in community meetings you are hit with the harsh reality: There are too many young people who do not get to experience lifes milestones, and there are too many families and communities forever changed due to gun violence.

As we think of the stories of those most impacted by gun violence, we must not forget the humanity of the communities we are looking to amplify and support. A huge part of this space must be ensuring that we are not doing harm in our efforts to support communities.

This means that we are building authentic relationships with the communities, and that they are recognized as the experts of their communities and of this work, as often they have been organizing for years unrecognized and unsupported. Outside of building meaningful relationships, it is imperative that we work to position communities and individuals to get the structural support to do violence prevention work, as so much of this work can be volunteer.

In addition, this work entails facilitating intentional relationships to have their work become sustainable, but also making sure state and national organizations are reflective of those most impacted. The only way we can continue to build a robust holistic movement is ensuring this movement is hiring members of the communities that are most impacted.

Gun violence is a multifaceted challenge that demands a holistic set of solutions to stop the cycles of daily gun violence in the most impacted communities. Those who are closest to the pain need to be closest to the power.

At The Educational Fund to Stop Gun Violence, we recognize that we must engage impacted communities specifically communities of color in our work to reduce gun deaths. We do this by first building genuine relationships with community members. We then use a research-grounded toolkit called Education to Action to turn these relationships into self-sustaining Community Action Networks that advocate for policies to reduce gun violence.

The Community Action Networks are self-sustaining advocacy groups from communities statewide. They advance an evidence-based, holistic approach to tackle gun violence in communities of color by hosting workshops and events that bring together law enforcement, community members, faith leaders and politicians.

They create a space for individuals who were disengaged from the political process to become active leaders within their communities, fighting for policies that will build healthy communities free of violence and inequity. They also act as a forum for skill-building, for instance in public relations and communications, and provide an opportunity for members to collaborate on the development of violence prevention programming.

Lauren Footman is a community engagement coordinator at The Educational Fund to Stop Gun Violence. She has been working in the violence prevention movement for seven years at the intersection of communities and policy.

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Communities of Color Must Be Centered in Gun Violence Prevention Movement - Juvenile Justice Information Exchange