World Cancer Day: Going back to the basics The genetics of cancer – Firstpost

We have all heard of the term gene and DNA, but little do we know about the impact of changes in them known commonly as genetic mutations. Most cancers are associated with these changes in specific genes which are sub-units of the genetic material, DNA. In this era of modern medicine & treatment, certain genetic mutations have been identified to be responsible for several diseases including cancer and targeting such mutations play a major role in the overall management of the disease, to improve the quality of the life and cure.

In the past two decades, there has been an increasing number of cancer cases in India. According to the Globocan 2018 data, about 1.16 million new cancer cases in India were reported with close to 7.9 lakh deaths. In India, the cancer subtypes in descending order are breast cancer (14 percent), lip/oral cavity cancers (10.4 percent), cervical cancer (8.4 percent), lung cancer (5.9 percent) and stomach cancer (5 percent) followed by others.

Most cancers are associated with changes in specific genes which are sub-units of the genetic material DNA.

The question that arises that How genetic testing would help in understanding genetic mutation and its relation to cancer/s? The simple answer to this question is, whatever one asks for. Genetic testing provides varied answers, starting from predisposition, and events before onset of cancer to treatment planning and monitoring as well as detection of early relapse/recurrence.

How can the genetic information related to cancer, be decoded even before the cancer onset? Well, the presence of certain gene mutations increases the chances of developing cancers drastically. These cancers are known as hereditary cancers, and the process is known as hereditary risk assessment. Understanding genetic mutations can help one understand whether there are increased chances of developing cancer. For example, any woman is at a 12 percent lifetime risk of developing breast cancer, in general population, but if there is a presence of harmful BRCA1 mutation, in a given individual due to inheritance, this risk can go as high as 70 percent.

Once cancer has developed, there are various ways in which these genetics tests can prove handy. Understanding genetic mutations can help the oncologist diagnose and differentially diagnose cancer subtypes in a more informed manner. Further certain genetic mutations help in understanding if the cancer progression will be aggressive or not. For example, in case of a leukaemia subtype: chronic lymphocytic leukaemia (CLL), the presence of IGHV gene mutation indicates that cancer wont progress aggressively. In medical terms it is known as good prognosis. On the other hand, there are some gene mutations that indicate poor prognosis of cancer as well.

Coming to the most known of application of genetic testing, we all have heard of what is called targeted treatment. Presence of certain gene mutations help the oncologists target the cancer as far as treatment is concerned. For example, in lung cancer, there are various classes of drugs that are based on gene mutations, such as EGFR inhibitors, which have a better effect on EGFR mutated lung cancers.

Certain genetic mutations help in understanding if the cancer progression will be aggressive or not.

Other applications of genetic testing include assessment of the treatment response for a given drug, also to detect the early recurrence in a periodic manner by a non-invasive procedure to check for cancer-specific mutations in the plasma of the blood sample, also known as liquid biopsy testing

Like all other subjects, cancer genetics is also something where India has certain unique features. There are multiple research papers that mention that in lung cancer, the prevalence of EGFR mutations is higher in south-Asian, particularly Indian population, as compared to the western populations. This provides an added advantage of treating these patients with targeted therapy for killing the specific cancer cells, thus avoiding the side effects associated with conventional chemotherapy. Hence understanding the mutation status of EGFR gene becomes imperative in case of lung cancers.

Similarly, there is a subclass of breast cancer called triple-negative breast cancers (TNBC), where there is an absence of receptors known to fuel breast cancer growth- Estrogen, Progesterone and Her-2/Neu gene. This is one of the most aggressive subtypes of breast cancer, where there are to targeted therapies available so far, and the standard of care remains conventional chemo-radiotherapy/surgery. Considering its aggressive behaviour the recurrence rates are very high in this subtype of cancers, and nearly 20 percent of these women are BRCA1/BRCA2 mutation carriers. As far as India is concerned, the triple-negative breast cancers incidence is higher in India (30 percent) as compared to the western population (12-17 percent), and have a poorer prognosis and survival (60 percent: 5 years age-adjusted survival) as compared to the Caucasian population (80 percent: 5 year age adjusted survival).

Talking about BRCA1 mutated breast cancers, one particular mutation, DelAG, is considered to be founder mutation in Ashkenazi Jewish community. Founder mutations is when a genetic alteration is observed with high frequency in a group that is or was geographically or culturally isolated, in which one or more of the ancestors was a carrier of the altered gene. In our experience, we have seen this founder mutation in Indian sub-population as well over and above Ashkenazi Jewish community.

In conclusion, genetic testing is aimed at providing clarity and insights about a persons cancer to the Oncologists that helps them make an informed decision. An increasing number of Oncologists have adopted genetic testing as an important tool for diagnosis and treatment planning of cancer and its management. Our constant effort is aimed to ensure, maximum number of cancer patients get benefitted by this technology in the society.

Dr Vidya Veldore is a principal scientist for Oncology at MedGenome Labs Ltd.

Updated Date: Feb 04, 2020 17:32:40 IST

Tags :Cancer,Cancer Day. World Cancer Day 2019,Cancer Patients,Diagnosis Of Cancer,DNA,Gene Mutations,Genes,Genetics Of Cancer,Genetics Tests,Oncologists,Oncology,Types Of Cancer,World Cancer Day

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World Cancer Day: Going back to the basics The genetics of cancer - Firstpost

Meet the PLOS ONE Cancer and Oncology Authors – PLoS Blogs

Today is World Cancer Day a day for raising the voices of cancer survivors, loved ones, and the people who are working endlessly to find solutions. This years theme is I am and I will: a recognition of the power each individual has to make an impact.

Each year, PLOS ONE publishes more than 1000 new research articles in cancer and oncology from authors who have dedicated their careers to studying this disease. In celebration of this years theme, were sharing their stories which inspired the science we use to understand and fight this disease.

My research group is mainly focused on the study of lung and pancreatic cancers, which are associated with high morbidity and mortality rates, worldwide. We use high throughput methods to identify new biomarkers and regulatory pathways and functional assays to improve our understanding of disease biology.

Patricia Pintor dos Reis, Faculty of Medicine, So Paulo State University UNESP Botucatu, SP, BRAZIL.

MicroRNA modulated networks of adaptive and innate immune response in pancreatic ductal adenocarcinoma.Tainara F. Felix, Rainer M. Lopez Lapa, Mrcio de Carvalho, Natlia Bertoni, Tomas Tokar, Rogrio A. Oliveira, et al

Bioinformatics is my tool and cancer research is my subject. My dad and many other people died of cancer and I want to uncover what causes cancer. And I love math and computers, which attracted me to become a bioinformatician. Now I am working for NCI initiative Ras program at Frederick National Lab for Cancer Research, which tries to tackle the most critical and ancient gene in cancer biology: Ras genes.

My last paper on PLOS ONE is about common pitfalls often seen in the survival analysis in the field. We wish to first alert researchers about the pitfalls when they perform survival analysis and to provided a novel method that shall help avoid the pitfalls.

Ming Yi, NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States of America

GradientScanSurvAn exhaustive association test method for gene expression data with censored survival outcome.Ming Yi, Ruoqing Zhu, Robert M. Stephens

The goal of my research is to develop an agent that promotes apoptosis in cancer cells but not in normal cells. To accomplish this goal, I explored different protein targets and pathways that included but are not limited to matrix type-I metalloprotease I (MT1-MMP), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), and oxidative stress.

Dmitri Rozanov, Department of Molecular and Medical Genetics, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, United States of America

Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity.Dmitri Rozanov, Anton Cheltsov, Aaron Nilsen, Christopher Boniface, Isaac Forquer, et al

I focus on H&N/Skull base cancers and mechanisms of treatment resistance within HPV positive and negative cancers. Understanding mechanism of treatment resistance will enable us to target new pathways for improving patient outcomes.

Dukagjin Blakaj, The James Cancer Center, Ohio State University, Columbus, OH, United States of America

Association of an intact E2 gene with higher HPV viral load, higher viral oncogene expression, and improved clinical outcome in HPV16 positive head and neck squamous cell carcinoma.Nicole V. Anayannis, Nicolas F. Schlecht, Miriam Ben-Dayan, Richard V. Smith, Thomas J. Belbin, et al

My particular area of research is the staging of colon cancer, it is important because colon cancer is a top 3 killer (of all cancer types) and we need new treatment strategies. However without accurate staging (i.e. determining how advanced the tumor is), it is nearly impossible to develop these new strategies.

Elias Nerad, The Netherlands Cancer Institute, Amsterdam The Netherlands.

The Apparent Diffusion Coefficient (ADC) is a useful biomarker in predicting metastatic colon cancer using the ADC-value of the primary tumor.Elias Nerad, Andrea Delli Pizzi, Doenja M. J. Lambregts, Monique Maas, Sharan Wadhwani, et al

I have always wanted to understand the incredible organization of brain functions and how to cure patients with brain lesions. My research field focuses on brain anatomy, brain functions, neuroimaging and how all these aspects together can improve the treatment of patients with cerebral tumors. My work tried to change the standard topographical classification of brain tumors to a model including more detailed information regarding the tumor infiltration along the white matter fibers.

This model perfectly fits the open access principle because it is not based on expensive technology, rather on a basic idea merging anatomy neuroimaging and oncology. I believe that anyone in the world can reproduce this classification method with standard MRI pictures contributing to a more extensive and shared knowledge in this field.

Francesco Latini, Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala, Sweden

A novel radiological classification system for cerebral gliomas: The Brain-Grid.Francesco Latini, Markus Fahlstrm, Shala G. Berntsson, Elna-Marie Larsson, Anja Smits, Mats Ryttlefors

Find out more about the causes of cancer and interventions to prevent and manage the disease in the PLOS Cancer Research Special Collection.

PLOS ONE will also be launching a Call for Papers for Cancer Metastasis research and invites submissions that report on the biochemical and cell biological basis of metastasis, including but not limited to cell adhesion, cell migration, cytoskeletal dynamics, cell polarity, tumour heterogeneity, tumour dormancy and the tumour microenvironment.

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Meet the PLOS ONE Cancer and Oncology Authors - PLoS Blogs

Brain links to embryonic immunity, guiding response of the troops that battle infections – Tufts Now

MEDFORD/SOMERVILLE, Mass. (February 4, 2020)Researchers led by biologists at Tufts University have discovered that the brains of developing embryos provide signals to a nascent immune system that help it ward off infections and significantly improve the embryos ability to survive a bacterial challenge. Using frog embryos, which continue to develop with their brains removed, the researchers found that embryos without a brain are not able to marshall the forces of immune cells to an injury or infection site, leading the embryo to succumb to an infection more quickly. By contrast, the presence of a brain crucially helps direct immune cells to the site of injury to overcome the bacterial threat. The study was published today in NPJ Regenerative Medicine.

In a developing embryo, both brain and immune system are not fully formed. The immune system, for its part, consists mostly of an innate system of cells that respond immediately to infection and do not require training or produce antibodies. Nevertheless, these cells require signals that prompt them to move toward an infection site and trigger a response.

The research team found that the brain appears to contribute to the signals that guide the nascent immune system. When brainless frog embryos were infected with E. coli, only about 16% of embryos survived, while the presence of a brain protected more than 50% from the infection. By following markers of immune cells, researchers confirmed that the effect is not due to the missing brain somehow hampering immune system development because the composition of the immune cells remained the same with or without a brain. Instead, they found that the effect was due to the brain sending signals to the immune cells to move toward the site of an infection.

We found that macrophages innate immune system cells that can swallow up bacteria and destroy them to reduce the burden of an infection do not migrate appropriately without the presence of the brain said Michael Levin, Vannevar Bush Professor of Biology at Tufts Universitys School or Arts and Sciences and Associate Faculty at Harvards Wyss Institute, director of the Allen Discovery Center at Tufts and corresponding author of the study. Without the brain and its neurotransmitter signals, gene expression and innate immune system activity go awry, resulting in increased susceptibility to bacterial pathogens.

Other roles for the embryonic brain signaling during infection may include inducing cellular responses, for example preventing cell death or reducing inflammation, that help protect against the harmful effects of the infection.

Immune system abberations were also observed in brainless embryos that were further developed. When the researchers tracked myeloid cells, a class of immune cells that includes macrophages, neutrophils and others, after an injury, they found that the myeloid cells in brainless embryos gathered in locations far from the injury site. By contrast, myeloid cells in normal embryos with intact brains would pile up at the injury site to assist in healing. In fact, in the brainless embryo, the myeloid cells tended to cluster around abnormal, disorganized peripheral nerve networks, also a by-product of brain absence, as demonstrated in earlier studies.

An examination of aberrations in genetic expression in brainless embryos also pointed to the reduction of the neurotransmitter dopamine (a signaling chemical used in the brain for learning and motivation), and that dopamine may play a role in activating immune cells to migrate in the early stages of an infection. The absence of an immune cell quorum at the infection site leads the brainless embryos to become more susectible to its lethal effects.

Our results demonstrate the deep interconnections within the bacteria-brain-body axis: the early brain is able to sense the pathogenic bacteria and to elaborate a response targeted to fight against the cellular and molecular consequences of the infection, said Celia Herrera Rincon, Research Scientist II at the Allen Discovery Center at Tufts, and first author of the study.

Other authors of this study include: Jean-Francois Par, Christina Harrison, Alina Fischer, and Sophia Jannetty at the Allen Discovery Center at Tufts; Christopher Martyniuk, associate professor in the Department of Physiological Sciences at University of Florida; and Alexandre Dinis and Vishal Keshari, graduate students, and Richard Novak, senior staff engineer at the Wyss Institute for Biologically Inspired Engineering, Harvard Universiy.

This research was supported by the Templeton World Charity Foundation Independent Research Fellowship (TWCF0241) and the Allen Discovery Center program through The Paul G. Allen Frontiers Group (12171), as well as The Defense Advanced Research Projects Agency(DARPA, W911NF-16-C-0050), and the National Institutes of Health (AR055993, AR061988). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Herrera-Rincon, C., Par, J-F, Martyniuk, C.J., Jannetty, S.K., Harrison, C., Fischer, A., Dinis, A., Keshari, V., Novak, R., and Levin, M. An in vivo brainbacteria interface:

the developing brain as a key regulator of innate immunity. NPJ Regenerative Medicine (31 Jan 2020) DOI: 10.1038/s41536-020-0087-2

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About Tufts University

Tufts University, located on campuses in Boston, Medford/Somerville and Grafton, Massachusetts, and in Talloires, France, is recognized among the premier research universities in the United States. Tufts enjoys a global reputation for academic excellence and for the preparation of students as leaders in a wide range of professions. A growing number of innovative teaching and research initiatives span all Tufts campuses, and collaboration among the faculty and students in the undergraduate, graduate and professional programs across the university's schools is widely encouraged.

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Brain links to embryonic immunity, guiding response of the troops that battle infections - Tufts Now

The Global Endocrinology Drugs Market is expected to grow by USD 24.78 bn during 2020-2024, progressing at a CAGR of 7% during the forecast period -…

Global Endocrinology Drugs Market 2020-2024 The analyst has been monitoring the global endocrinology drugs market and it is poised to grow by USD 24. 78 bn during 2020-2024, progressing at a CAGR of 7% during the forecast period.

New York, Feb. 04, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Global Endocrinology Drugs Market 2020-2024" - https://www.reportlinker.com/p03793964/?utm_source=GNW Our reports on global endocrinology drugs market provides a holistic analysis, market size and forecast, trends, growth drivers, and challenges, as well as vendor analysis covering around 25 vendors. The report offers an up-to-date analysis regarding the current global market scenario, latest trends and drivers, and the overall market environment. The market is driven by increase in incidence of endocrine disorders. In addition, association between obesity and endocrine disorders is anticipated to boost the growth of the global endocrinology drugs market as well.

Market Segmentation The global endocrinology drugs market is segmented as below: Therapy area Diabetes Drugs Thyroid Hormone Disorder Drugs HGH Testosterone Replacement Therapy Others

Geographic segmentation North America Europe Asia ROW

Key Trends for global endocrinology drugs market growth This study identifies association between obesity and endocrine disorders as the prime reasons driving the global endocrinology drugs market growth during the next few years. Prominent vendors in global endocrinology drugs market We provide a detailed analysis of around 25 vendors operating in the global endocrinology drugs market, including some of the vendors such as Abbott Laboratories, AbbVie Inc., AstraZeneca Plc, Eli Lilly and Co., GlaxoSmithKline Plc, Groupe Sanofi, Merck & Co. Inc., Novartis International AG, Novo Nordisk AS and Pfizer Inc. The study was conducted using an objective combination of primary and secondary information including inputs from key participants in the industry. The report contains a comprehensive market and vendor landscape in addition to an analysis of the key vendors.Read the full report: https://www.reportlinker.com/p03793964/?utm_source=GNW

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Testosterone Replacement Therapy Market 2020-2027 is booming in forthcoming year by Leading Players AbbVie – Briotainment

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Testosterone Replacement Therapy Market 2020-2027 is booming in forthcoming year by Leading Players AbbVie - Briotainment

Nano 2020: Scaling Up Nanotechnology in Virtual Reality – UANews

Sometimes the smallest of things lead to the biggest ideas. Case in point: Nano 2020, a University of Arizona-led initiative to develop curriculum and technology focused on educating students in the rapidly expanding field of nanotechnology.

The five-year, multi-university project recently met its goal of creating globally relevant and implementable curricula and instructional technologies, to include a virtual reality classroom, that enhance the capacity of educators to teach students about innovative nanotechnology applications in agriculture and the life sciences.

Visualizing What is Too Small to be Seen

Nanotechnology involves particles and devices developed and used at the scale of 100 nanometers or less to put that in perspective, the average diameter of a human hair is 80,000 nanometers. The extremely small scale can make comprehension challenging when it comes to learning about things that cannot be seen with the naked eye.

That's where the Nano 2020 virtual reality classroom comes in. In a custom-developed VR classroom complete with a laboratory, nanoscale objects come to life for students thanks to the power of science data visualization.

Within the VR environment, students can interact with objects of nanoscale proportions pick them up, turn them around and examine every nuance of things that would otherwise be too small to see. Students can also interact with their instructor or their peers. The Nano 2020 classroom allows for multi-player functionality, giving educators and students the opportunity to connect in a VR laboratory in real time, no matter where they are in the world.

"The virtual reality technology brings to life this complex content in a way that is oddly simple," said Matt Mars, associate professor of agricultural leadership and innovation education in the College of Agriculture and Life Sciences and co-director of the Nano 2020 grant. "Imagine if you can take a student and they see a nanometer from a distance, and then they're able to approach it and see how small it is by actually being in it. It's mind-blowing, but in a way that students will be like, 'Oh wow, that is really cool!'"

The technology was developed by Tech Core, a group of student programmers and developers led by director Ash Black in the Eller College of Management.

"The thing that I was the most fascinated with from the beginning was playing with a sense of scale," said Black, a lifelong technologist and mentor-in-residence at the McGuire Center for Entrepreneurship. "What really intrigued me about virtual reality is that it is a tool where scale is elastic you can dial it up and dial it down. Obviously, with nanotechnology, you're dealing with very, very small things that nobody has seen yet, so it seemed like a perfect use of virtual reality."

Black and Tech Core students including Robert Johnson, Hazza Alkaabi, Matthew Romero, Devon Oberdan, Brandon Erickson and Tim Lukau turned science data into an object, the object into an image, and the image into a 3D rendering that is functional in the VR environment they built.

"I think that being able to interact with objects of nanoscale data in this environment will result in a lot of light bulbs going off in the students' minds. I think they'll get it," Black said. "To be able to experience something that is abstract like, what does a carbon atom look like well, if you can actually look at it, that's suddenly a whole lot of context."

The VR classroom complements the Nano 2020 curriculum, which globally expands the opportunities for nanotechnology education within the fields of agriculture and the life sciences.

Teaching the Workforce of the Future

"There have been great advances to the use of nanotechnology in the health sciences, but many more opportunities for innovation in this area still exist in the agriculture fields. The idea is to be able to advance these opportunities for innovation by providing some educational tools," said Randy Burd, who was a nutritional sciences professor at the University of Arizona when he started the Nano 2020 project with funding from a National Institute of Food and Agriculture Higher Education Challenge grant through the United States Department of Agriculture. "It not only will give students the basics of the understanding of the applications, but will give them the innovative thought processes to think of new creations. That's the real key."

The goal of the Nano 2020 team, which includes faculty from the University of Arizona, Northern Arizona University and Johns Hopkins University, was to create an online suite of undergraduate courses that was not university-specific, but could be accessed and added to by educators to reach students around the world.

To that end, the team built modular courses in nanotechnology subjects such as glycobiology, optical microscopy and histology, nanomicroscopy techniques, nutritional genomics, applications of magnetic nanotechnology, and design, innovation, and entrepreneurship, to name a few. An online library will be created to facilitate the ongoing expansion of the open-source curricula, which will be disseminated through novel technologies such as the virtual reality classroom.

"It isn't practical to think that other universities and colleges are just going to be able to launch new courses, because they still need people to teach those courses," Mars said. "So we created a robust and flexible set of module-based course packages that include exercises, lectures, videos, power points, tools. Instructors will be able to pull out components and integrate them into what already exists to continue to move toward a more comprehensive offering in nanotechnology education."

According to Mars, the highly adaptable nature of the curriculum and the ability to deliver it in various ways were key components of the Nano 2020 project.

"We approach the project with a strong entrepreneurial mindset and heavy emphasis on innovation. We wanted it to be broadly defined and flexible in structure, so that other institutions access and model the curricula, see its foundation, and adapt that to what their needs were to begin to disseminate the notion of nanotechnology as an underdeveloped but really important field within the larger landscape of agriculture and life sciences," Mars said. "We wanted to also provide an overlay to the scientific and technological components that would be about adoption in human application, and we approached that through an innovation and entrepreneurial leadership lens."

Portions of the Nano 2020 curriculum are currently being offered as electives in a certificate program through the Department of Agriculture Education, Technology and Innovation at the University of Arizona. As it becomes more widely disseminated through the higher education community at large, researchers expect the curriculum and VR classroom technology to transcend the boundaries of discipline, institution and geography.

"An online open platform will exist where people can download components and courses, and all of it is framed by the technology, so that these experiences and research can be shared over this virtual reality component," Burd said. "It's technologically distinct from what exists now."

"The idea is that it's not just curriculum, but it's the delivery of that curriculum, and the delivery of that curriculum in various ways," Mars said. "There's a relatability that comes with the virtual reality that I think is really cool. It allows students to relate to something as abstract as a nanometer, and that is what is really exciting."

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Nano 2020: Scaling Up Nanotechnology in Virtual Reality - UANews

How China Is The Future of Nanoscience – OZY

Everything about Chinas drive to become a leading innovator works on a giant scale. Ambitions are enormous, budgets are vast and the focus is widespread. And in many fields, its beginning to close the gap with U.S. and European institutions. But its in the study of materials on the scale of a billionth of a meter nanoscience that China is already fast overtaking its international rivals.

From cloning to cancer research, China is using nanoscience and nanotechnology innovation to drive some of the worlds biggest breakthroughs. In July, an international team of researchers led by Chinese scientists developed a new form of synthetic, biodegradable nanoparticle. Capable of targeting, penetrating and altering cells by delivering the CRISPR/Cas9 gene-editing tool into a cell, the nanoparticle can be used in the treatment of some single-gene disorders, as well as other diseases including some forms of cancer.

In a separate project, scientists at Chinas Nanjing University haveused nanoparticles to target and destroy abnormal proteins known to causebreast cancer. Tests in mice showed the treatment reduced the size of tumors byhalf compared to the control group. At the University of Science and Technologyof China, a team of researchers claims to have given mice infrared night visionby injecting nanoparticles into their eyes.

And at the State Key Laboratory of Robotics in the northeast city of Shenyang, researchers have developed a laser that produces a tiny gas bubble. This bubble can be used as a tiny robot to manipulate and move materials on a nanoscale with microscopic precision. The technology promises new possibilities in the field of artificial tissue creation and cloning.These innovations are backed up by a scale of research thats unmatched. In 2018, Chinese researchers were on their own responsible for 40 percent of all global scientific papers in the field, with the U.S. (15 percent) a distant second.

Nanotechnology supports biomedicine and quantum technology development and makes its way into everyday life through advancements in consumer electronics and artificial intelligence, all areas where China seeks global dominance. Being at the forefront of cutting-edge nano research greatly improves Chinas prospects for success, especially in biomedicine, where it has long trailed rivals.

Drug delivery, nanomedicine and tissue engineering are rapidly growing fields that rely on our ability to engineernanoparticles and biomaterialstargeted at specific cells, such as cancer cells,to enhance the therapeutic efficacy, says Dr. Omid Kavehei, deputy director of the University of Sydney Nano Institute.

Chinas gains could help it win critical patents in advanced research in fields like cancer, where the U.S. has historically led.

Strong state support in nanoscience as in tech fields such as artificial intelligence and robotics is also a key advantage for China, Bai Chunli, president of the Chinese Academy of Sciences (CAS), conceded publicly in August. The importance the government places on competitiveness in the field is underlined by its inclusion as a strategic industry in Chinas 13th Five-Year Plan, ensuring state funding and legislative and regulatory support. Nanotech research is also a key component of the ambitious Made in China 2025 initiative aimed at turning China into a high-tech manufacturing powerhouse.

Thats allowing China to find success in myriad areas of nanotechnology. A new nanomaterial invented by CAS scientists promises to eliminate millions of metric tons of liquid pollution and emissions from organic chemicals used in printing plates and ink. It is one of the headline acts for CAS as it drives to apply nanotechnology innovation to the development of consumer tech. So far, the project has landed $780 million in investment.

China still relies on collaborations with foreign institutions in most of the subfields of nanoscience and nanotechnology.

Shengfu Yang, University of Leicester

In an October 2019 paper published by science journalNano Energy, Dalian Institute of Chemical Physics announced the creation of a tiny lithium battery that is resilient to low temperatures, capable of operating at 80 percent efficiency at temperatures of -40 degrees Celsius. While the battery presents huge potential for industries from electric cars to mobile devices, the ability of the battery to operate at extreme temperatures is particularly important to the future of space technology.

Industry experts point to the return of foreign-trained Chinese researchers to the Middle Kingdom, lured by the promise of readily available funding, as an important factor of Chinas progress. The next step is for China to become self-sufficient in developing talent. Currently China still relies on collaborations with foreign institutions in most of the subfields of nanoscience and nanotechnology, says Shengfu Yang, nanochemistry professor at the University of Leicester. The nanoparticle that delivers the gene-editing tool into cells was developed in partnership with scientists at Tufts University in the United States, for instance.

Enhancing innovation in the private sector will also help China kick on, says Zheng Xiao Guo, professor of chemistry and mechanical engineering at the University of Hong Kong. State-funded institutions have played a far bigger role in nanotechnology innovations, and private institutions or enterprises in this area are not as strong, he says.

But the number of private companies driving nanotech product innovation is rapidly growing, Zheng concedes. Nanopolis, the worlds largest nanotech industrial zone, located in the eastern city of Suzhou, houses several private multinationals and new Chinese startups across nanotech fields. China now also leads the globe in newly established nanotech companies. In 2018, Tencent founder Ma Huateng joined a number of high-profile businesspeople in financing the establishment ofChinas first private research institute,Westlake University, with nanotech a main focus for research.

Private-sector involvement opens new and unique pools of funding and talent, and the focus is on applicable research even in a country like China, where state-sponsored institutions still dominate, say experts.

That combination of a growing talent pool and a state-sponsored desire to become a global leader, with an expanding private-sector ecosystem, will be hard for other countries to match. Chinas big leap in small science is just starting.

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How China Is The Future of Nanoscience - OZY

In State of the City address, Mayor Ardis praises Peoria innovation – Peoria Journal Star

PEORIA The state of the city is innovative. And innovators on a broader geographic scale appear to be headed here soon.

That was part of the message Peoria Mayor Jim Ardis conveyed Tuesday in his annual State of the City address.

The focus of his speech, given in front of a lunch-hour crowd at the Peoria Civic Center, was on local entrepreneurs, researchers and others of similar aspirations.

Among the entities Ardis mentioned were the creators of Enduvo, a medical virtual-reality training tool; Natural Fiber Welding Inc., which uses plant-based alternatives to leather and plastics; and NTS Innovations, which is focusing on nanotechnology to boost energy output without creating pollution.

"This isn't pie in the sky," Ardis said following his speech. "(They) have a lot of potential to change things, not just in Peoria but, in the space that they're in, so many things around the globe."

At least some of that globe is expected to visit Peoria this spring as part of an international entrepreneurial and innovation competition.

Peoria is to be the only U.S. site for the Future Agro Challenge, to be held April 13-15 at the Civic Center. The aim is to seek sustainable solutions to global food insecurity, biodiversity and climate change.

As many as 300 competitors from nine Midwestern states are expected, according to Jake Hamann, executive director of the recently formed Peoria Innovation Alliance.

Future Agro Challenge organizers last attempted a U.S. competition a few years ago in Las Cruces, N.M.

According to Hamann, Peoria was attractive because it's centrally located and because it's home of the National Center for Agricultural Utilization Research, commonly known as the federal Ag Lab.

"It shines a spotlight on what we've got going on here, it brings exposure to us as a community and it shows we've got the resources to support if any of these companies make a connection with the Ag Lab," Hamann said.

Judges in Peoria are to select a winner from among as many as 40 entries. Among possible local competitors include a composting service and a developer of a digital ledger that traces foodstuffs from farm to table, Hamann said.

The winner is to receive a cash award and an all-expenses-paid trip to the international competition, to be held in October in Thessaloniki, Greece.

Some of what local innovators are producing has roots elsewhere. NTS' energy-harvesting technology was developed at the University of Arkansas, for example.

But NTS founder and CEO Don Meyer doesn't appear interested in moving his operation to Fayetteville. Or anywhere else.

"We have offers from around the country to put our global headquarters somewhere, but you know, I told Jim yesterday, 'I want to keep it at home,'" Meyer said. "So if we can do that and build a community ... that's the key."

Nick Vlahos can be reached at 686-3285 or nvlahos@pjstar.com. Follow him on Twitter @VlahosNick.

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In State of the City address, Mayor Ardis praises Peoria innovation - Peoria Journal Star

Renowned Harvard chemistry professor charged with lying about ties to China – World Socialist Web Site

Renowned Harvard chemistry professor charged with lying about ties to China By Kevin Reed 3 February 2020

World-renowned Harvard University chemistry professor Charles Lieber appeared in court on Thursday in handcuffs, ankle chains and an orange jumpsuit as he was charged with lying about his ties to China.

The bail for Lieber, head of Harvards Chemistry and Chemical Biology Department, was set at $1 million as he was formally accused, along with two Chinese nationals, of illegally aiding the Peoples Republic of China by the US Justice Department.

A DOJ press release issued on Tuesday, the day the 60-year-old Lieber was arrested at his office, said that the Harvard department chair was being criminally charged with one count of making a materially false, fictitious and fraudulent statement.

The cases against the Chinese nationals are separate from Liebers. Yanqing Ye, 29, currently in China, was charged with one count each of visa fraud, making false statements, acting as an agent of a foreign government and conspiracy. Zaosong Zheng, 30, was arrested on December 10, 2019 at Bostons Logan International Airport and charged with attempting to smuggle vials of biological research into China. On January 21, 2020, Zheng was also indicted on one count of smuggling goods from the US and one count of making false, fictitious or fraudulent statements. He has been held in jail since December 30, 2019.

The crux of the case against Lieber is the claim that he lied about his involvement with a program called the Thousand Talents Plan, a program that is alleged to be aimed at luring people with knowledge of foreign technology and intellectual property to China.

The DOJ statement says Unbeknownst to Harvard University beginning in 2011, Lieber became a Strategic Scientist at Wuhan University of Technology (WUT) in China and was a contractual participant in Chinas Thousand Talents Plan from in or about 2012 to 2017. Under the terms of Liebers three-year Thousand Talents contract, WUT paid Lieber $50,000 USD per month, living expenses of up to 1,000,000 Chinese Yuan (approximately $158,000 USD at the time) and awarded him more than $1.5 million to establish a research lab at WUT.

The DOJ document states further that Lieber, during an interview with investigators in April 2018, stated that he was never asked to participate in the Thousand Talents Program, but wasnt sure how China categorized him. Oddly, the criminal complaint also states that, in November 2018, Lieber caused Harvard to falsely tell NIH that Lieber had no formal association with WUT after 2012, that WUT continued to falsely exaggerate his involvement with WUT in subsequent years, and that Lieber is not and has never been a participant in Chinas Thousand Talents Plan.

If convicted, Lieber faces up to five years in federal prison and a maximum fine of $250,000. The university has placed him on paid administrative leave.

A sense of the political motivations behind the aggressive treatment of Lieber was provided by US attorney Andrew Lelling who called the charges against the professor a, small sample of Chinas ongoing campaign to siphon off Americas technology and know-how for its countrys gain.

Boston FBI agent Joseph Bonavolonta provided further insight into the motivation for the charges against the Harvard professor, No country poses a greater, more severe or long-term threat to our national security and economic prosperity than China. Chinas communist governments goal, simply put, is to replace the US as the world superpower, and they are breaking the law to get there.

The New York Times reported in November 2019 that there were at that time 180 open investigations at 71 universities across the US into potential intellectual property theft, including most of the top medical schools. Almost all of the individuals targeted are of Chinese descent, including naturalized American citizens.

Dr. Liebers biography shows that he is a leading international authority on nanoscience and nanotechnology with over 400 papers published on these topics. Nanotechnology deals with the manipulation of matter at the atomic and molecular level and it is a new scientific frontier with vast implications for the future of multiple disciplines and across industries. Lieber is the principle inventor on over fifty US patents and applications of nanotechnology and nanodevices in materials and biology.

Additionally, a review of the top nanotechnology research organizations in the world shows that the US--at the University of California, Berkeley--ranks at number seven behind China, Russia, France and Japan in this area of study and far behind South Korea and Japan in the category of commercial patents.

The arrest and charges against Dr. Lieber come in the context of the Trump administrations trade war Beijing and preparations for open war with the second largest economy in the world. The DOJ case against Lieber bears unmistakable characteristics of an extreme response by the American ruling elite to its declining position in relation to significant areas of scientific research and development internationally. There can be no question that the case against Lieber is intended to intimidate American scientists from engaging in any way with their Chinese colleagues on scientific projects.

2019 has been a year of mass social upheaval. We need you to help the WSWS and ICFI make 2020 the year of international socialist revival. We must expand our work and our influence in the international working class. If you agree, donate today. Thank you.

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Renowned Harvard chemistry professor charged with lying about ties to China - World Socialist Web Site

Valiant Spoils Bloodshot Movie by Releasing Novelization a Week Before Film Hits Theaters – Bleeding Cool News

Spoilers are a problem across all forms of media, and theres seemingly no way to stop them. But Valiant Entertainment has at least found a way to capitalize on them. Teaming up with Titan Books, Valiant has released full spoilers for their upcoming Bloodshot film in the form of a novelization of the movie. Thanks to this novel by Gavin Smith, moviegoers can find out everything that happens in the film by reading the book over a month before it hits North American theaters, so long as they can read, which is technically not a given for all Bloodshot fans. Just kidding. Maybe.

Below, check out the books official synopsis:

BEING A HERO IS IN HIS BLOOD

After he and his wife are murdered, Marine Ray Garrison is resurrected by a secret team of scientists. Enhanced with nanotechnology, he becomes a superhuman, biotech killing machine Bloodshot without any memory of his previous life.

But some things cant stay buried, and Ray refuses to back down when his memories begin to surface. Haunted by the face of his familys killer, he will stop at nothing to take his revenge and discovers a conspiracy going deeper than he could have possibly imagined

THE BOOK CONTAINS AN EXCLUSIVE SHORT STORY TITLED INTO THE FIRE

Sony Pictures Bloodshot is scheduled to rollout worldwide beginning February 2020 and is scheduled to hit North American cinemas on March 13, 2020. Based on the bestselling comic book, the film stars Vin Diesel as Ray Garrison, a soldier recently killed in action and brought back to life as the superhero Bloodshot by the RST corporation. With an army of nanotechnology in his veins, hes an unstoppable force stronger than ever and able to heal instantly. But in controlling his body, the company has sway over his mind and memories, too. Now, Ray doesnt know whats real and whats not but hes on a mission to find out.

The film is directed by David S. F. Wilson. The screenplay is by Jeff Wadlow and Eric Heisserer and the story by Jeff Wadlow. The film stars Vin Diesel, Eiza Gonzalez, Sam Heughan, Toby Kebbell and Guy Pearce.

Gavin Smith, who has authored the official novelization, has a strong record of writing successful tie-in fiction and has previously written for properties such as Crysis and Elite.

ISBN: 9781789093087 | February 4th 2020 | Paperback & eBook | 336 pages | $8.99

A prophecy says that in the comic book industry's darkest days, a hero will come to lead the people through a plague of overpriced floppies, incentive variant covers, #1 issue reboots, and super-mega-crossover events.

Scourge of Rich Johnston, maker of puns, and seeker of the Snyder Cut, Jude Terror, sadly, is not the hero comics needs right now... but he's the one the industry deserves.

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Valiant Spoils Bloodshot Movie by Releasing Novelization a Week Before Film Hits Theaters - Bleeding Cool News

Blueberry Therapeutics receives clearance from the FDA to proceed with the clinical investigation of BB2603 – PMLiVE

Blueberry Therapeutics has received an investigational new drug (IND) clearance from the Food and Drug Administration (FDA) to proceed with the clinical development of BB2603

Alderley Park, UK, January 2020

Blueberry Therapeutics has received an investigational new drug (IND) clearance from the Food and Drug Administration (FDA) to proceed with the clinical development of BB2603 for the treatment of onychomycosis.

The IND is a crucial milestone in the continued development of BB2603, a nanoformulated, topical form of terbinafine for the treatment of onychomycosis (fungal toenail). With the IND in place the company has initiated a Phase IIb international, multicentre double-blinded study.

The primary outcome of this study is to look at the efficacy BB2603 in onychomycosis, with a secondary dose finding outcome also being investigated.

John Ridden, CEO said: Having received clearance from the FDA we are looking forward to the opportunity to work with over 20 international sites on the Phase IIb trial of BB2603 with the first patient expected to be recruited in March 2020.This is a key milestone in our path to commercialisation of our nanotechnology product portfolio.

With BB2603, Blueberry Therapeutics aim to maintain the efficacy of the oral gold standard treatment, but at a lower dose. Delivering the active pharmaceutical ingredient using nanotechnology ensures it penetrates across the nail plate and reaches the target site of action in a controlled manner, meaning lower doses can be used and systemic side effects are minimised.

ENDS

Blueberry Therapeutics Limited Media Contact

Elle Bell Onyx Health

ebell@onyxhealth.com

Tel: +44 (0) 191 640 3638

Notes to Editors

About Blueberry Therapeutics Limited

Blueberry Therapeutics Ltd., incorporated in November 2011, is a drug discovery and development company focused on developing innovative nanomedicines for difficult to treat skin and nail infections.The company is using its state-of-the-art nanotechnology to develop high value medicines where a reduced dose and improved drug delivery is needed, to overcome existing efficacy, tolerability and safety profile concerns.

Blueberry Therapeutics combines expert in-house resources with selected outsource partners and collaborators to take projects through from preclinical research onto de-risked human clinical proof of concept and then on to the market. For more information, please visit http://www.blueberrytherapeutics.com

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Blueberry Therapeutics receives clearance from the FDA to proceed with the clinical investigation of BB2603 - PMLiVE

India, Norway ink 4 MoUs in field of research, higher education – Outlook India

New Delhi, Feb 4 (PTI) India and Norway on Tuesday signed four MoUs in the field of research and higher education to strengthen their bilateral partnership.

The agreements were signed here during the visit of a delegation of prominent education and research institutions from Norway led by Director-General, Anne Line Wold, Norwegian Ministry of Education and Research.

One agreement was inked between the Indian Institute of Technology Delhi and UiT, The Arctic University of Norway, for cooperation in fields such as bio-photonics, health and diagnostic tools, nanotechnology, water management and renewable energy.

Another MoU was signed between the Indraprastha Institute of Information Technology and UiT, The Arctic University of Norway, to facilitate exchange of students and staff and consolidate joint efforts towards project initiatives in national and EU arena.

The other agreements were signed between IIT Jammu and Norwegian University of Science and Technology, and IIT Mandi and Norwegian University of Science and Technology with special focus on activities in landslides, tunnels, water management, hydropower, project-based learning, student and researchers mobility and cold region technologies.

The agreement signing was witnessed by Norwegian Ambassador to India Hans Jacob Frydenlund and the head of the delegation.

"The visiting delegation from Norway has had fruitful meetings with their Indian counterparts to discuss increased student mobility between Norway and India," Frydenlund said on the occasion.

"As a part of the Norwegian government''s India Strategy 2030, research cooperation and higher education are of high importance in our bilateral relationship," he said.

This visit is a key step towards achieving the goals of a stronger and deeper bilateral relationship with India in the field of higher education, Frydenlund said.

Wold said India is an important strategic partner for Norway within higher education and research.

"For Norway, exploring potential partners and connecting researchers and institutions with their counterparts in India is extremely crucial. During this visit, we have had an excellent dialogue with the Indian authorities and found several areas of common interest that will benefit both countries," she said. PTI ASK ASK ABHABH

Disclaimer :- This story has not been edited by Outlook staff and is auto-generated from news agency feeds. Source: PTI

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India, Norway ink 4 MoUs in field of research, higher education - Outlook India

Ezekiel-ion | The glasses you want to wear all the time, launched on Kickstarter – Benzinga

World's first luxury nanotech eyewear with advanced eye protection and therapeutic functions just launched on Kickstarter. Ezekiel-ion glasses do more than just protecting the users' eyes from blue light, UV and EMF radiation but also help the eyes heal themselves from existing eye conditions and offer functions not found in any of today's eye glasses.

TORONTO (PRWEB) February 04, 2020

Ezekiel-ion, an Ontario, Canada-based nanotechnology company that designs and creates eyewear for eye health, protection, and preservation in a world filled with harmful digital screens, UV rays, and EMF radiation, today announced they are launching Kickstarter crowdfunding campaign for the first-ever luxury nanotech eyewear with advanced eye protection and therapeutic functions.

Our eyes are bombarded with blue light from digital screens, UV rays from the sun and EMF radiation from electronic devices. Many suffered dry eyes, red eyes, eye strain, blurred vision, headaches, and even brain tumors as a result. On top of these, many people already are living with vision impairment, such as eye floaters, astigmatism, myopia, presbyopia, cataract, and other eye problems.

"We've created a new kind of glasses that will do more than just keeping the eyes from the damage that seeps through all of our screens today," said Jack Huang, Founder, and Owner of Ezekiel-ion, Inc. "Ezekiel-ion glasses will not only protect against blue light, UV and EMF radiation, they will also have the unique ability to actually help improve eye health through our proprietary nanotech frames that release negative ions and far-infrared (FIR). They will even filter the air we breathe. This may sound incredible, but they are scientifically proven.*"

Scientific studies have shown that negative ions and FIR help the body to heal itself*, potentially relieving myopia, eye floaters, astigmatism, dry and red eyes, cataracts, eye bags, and glaucoma. In a nutshell, these glasses release natural healing negative ions and FIR that are going to help eyes everywhere.

"We are only given one pair of eyes in this lifetime; how you treat them is up to you," said Huang. "That's why we are excited to announce the launching of our Kickstarter campaign. We invite you to be part of this visual movement."

The new Ezekiel-ion glasses offer the users effective protection from blue light, UV and EMF radiation as well as releasing negative ions and far-infrared. In doing so, Ezekiel-ion glasses help improve existing eye conditions and offer functions not found in any of today's eye glasses.

For more information, visit:

Kickstarter: https://www.kickstarter.com/projects/ezekiel-ion/ezekiel-ion-the-glasses-you-want-to-wear-all-the-time

Company website: https://www.ezekiel-ion.com

*References (examples):

1. Far infrared radiation (FIR): its biological effects and medical applications, 2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699878/

2. Far-Infrared Therapy Promotes Nerve Repair following End-to-End Neurorrhaphy in Rat Models of Sciatic Nerve Injury, 2015 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333284/

3. Negative Air Ions and Their Effects on Human Health and Air Quality Improvement, 2018 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213340/

4. Water-generated negative air ions activate NK cell and inhibit carcinogenesis in mice, 2005. https://www.ncbi.nlm.nih.gov/pubmed/16171944

For the original version on PRWeb visit: https://www.prweb.com/releases/ezekiel_ion_the_glasses_you_want_to_wear_all_the_time_launched_on_kickstarter/prweb16883830.htm

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Ezekiel-ion | The glasses you want to wear all the time, launched on Kickstarter - Benzinga

Opinion | Prepare for a world of quantum haves and have-nots – Livemint

Buried within the 13,000-odd words of the Union Budget speech on Saturday was a paragraph that set aside 8,000 crore over five years for the National Mission on Quantum Technologies and Applications. Most commentators seem to have either missed or overlooked this budgetary allocation, but in terms of significance, the implications are well worth considering.

More than two years ago, the department of science and technology launched the Quantum-Enabled Science and Technology (QuEST) programme with an aim to develop technical capacity within the country to build quantum computers and communications systems comparable with the best in the world. The first phase of the project was to build the infrastructure and acquire human resources to develop physical and computation structures for improving precision in quantum measurement. The eventual goal is to build quantum computers domestically.

Though the allocation in this years budget is clearly part of a long-term national strategy, I cannot help wonder whether it is, at least in some small measure, a response to Googles recent announcement that it had achieved quantum supremacy"the ability to perform a calculation on a quantum computer that is impossible on a conventional computer. And the fear that we might, once again, be falling behind.

As much as I enjoy science, quantum mechanics gives me a headache. Quantum computing is an order of magnitude more perplexing. Ordinary computers function using binary logic gates that can be either off or on. This is why classical computers store information in bitseither as a 0 or 1. On the other hand, quantum computers can store information as both a 0 and a 1 at the same time using a quantum property called superposition. This means that with two quantum bits (or qubits), information can be stored in four possible states of superposition, and as more qubits are added, the computational power grows exponentially.

While this gives us more computing power, quantum computers are error-prone. The quantum state is delicate. It lasts for a fraction of a second and is easily disrupted by tiniest of vibrations or variations in temperature. This noise" in calculations causes mistakes to occur, and unless we can make them sufficiently error-free, quantum computing will not be commercially viable. Googles breakthrough was to achieve sufficient control over the process to allow its experimental computer to outperform a traditional computer. As a result, its computer could solve in 200 seconds what would take the worlds fastest supercomputer 10,000 years.

We still have a long way to go before quantum computing becomes commercially viable, but there is reason for urgency. As soon as quantum computing becomes commercially viable, much of what we take for granted today will become irrelevant.

Take encryption, for example. Almost all digital security today is based on the RSA algorithm that encrypts messages by relying on the factorization of two large prime numbers. While it is easy to multiply two prime numbers, it is very difficult to factorize them. RSA encryption exploits this feature, making it impossible for even governments and private actors with near infinite computational resources to decrypt messages. This is why we have the confidence to store valuable information in encrypted archives on the cloud, secure in the knowledge that even the largest corporations and most technologically advanced governments dont have the computational capability to decrypt these databases and access the information stored inside.

Once quantum computers are capable of being used for decryption, the computational hurdles of prime number factorization that we now rely on will become trivial to overcome. Shors algorithm already describes a process by which quantum computers could be used find the prime factors of any integer. In 2001, IBM proved that this algorithm works by using a 7 qubit computer to factorize the number 15 into 5 and 3. Googles Sycamore processor harnessed 53 qubits in its latest experiment, demonstrating that much higher computational capabilities are already within our grasp. Once our quantum computers have reached a sufficiently advanced level of stability, even the highest encryption known to man will be easy to defeat.

When that happens, cyber security as we know it will be a thing of the past. All the secure data services that we rely on will be thrown wide open, allowing anyone with a quantum computer to easily access the information within. Given the imminence of major breakthroughs in quantum computing, it is rumoured that there is already an underground market for encrypted data in anticipation of a time when all this information can be decrypted and the secrets of famous personalities can be exposed.

In the war for quantum supremacy, it is those who can understand and use the fundamental technologies behind quantum computing who will emerge dominant. In the not-so-distant future, the world will be divided into the quantum haves and have-nots. It is imperative that India makes every effort to stay in the game if it is to have any hope of remaining relevant. If we are to retain any measure of technological independence, we will need to ramp up our research in quantum computing and actively invest in the development of indigenous quantum computational capabilities.

Rahul Matthan is a partner at Trilegal and author of Privacy 3.0: Unlocking Our Data Driven Future

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Opinion | Prepare for a world of quantum haves and have-nots - Livemint

IBM Tops U.S. Patent List for 2019 With Innovations in AI, Blockchain, Cloud and Quantum Computing – Database Trends and Applications

IBM inventors received 9,262 U.S. patents in 2019, achieving a milestone of most patents ever awarded to a U.S. company, and marking the company's 27thconsecutive year of U.S. patent leadership.

In 2019,IBM led the industryin the number of U.S. patents granted across key technology areas such as AI, blockchain, cloud computing, quantum computing and security.

In 2019, according toIFI CLAIMS Patent Services,provider of a global patent data platform, U.S. patent filings hit an all-time high with 333,530 patents granted, representing an unprecedented 15% increase from 2018.

IBM was awarded more than 1,800 AI patents, including a method for teaching AI systems how to understand and deduce the nuances and implications behind certain text or phrases of speech by analyzing other related content.

IBM also led in the number of blockchain patents granted, which includes several patents for improving the security of blockchain networks. One patented technique would help in resisting "replay attacks," where an attacker copies and uses signature information from one transaction on a blockchain to later perform other transactions on the blockchain that are not authorized.

IBM inventors were granted more than 2,500 patents in cloud technology, including a patent for a method to jointly manage cloud and non-cloud computing platforms. Working with a unified portal, this technique receives, organizes and streamlines incoming cloud and non-cloud tasks and requests, which could help organizations easily migrate to hybrid cloud platforms.

IBM's quantum computing program continued to grow in 2019. Quantum computing innovations by IBM included a method to scale a quantum computer to support additional qubits, as well as enabling a breakthrough approach for simulating molecules.

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IBM Tops U.S. Patent List for 2019 With Innovations in AI, Blockchain, Cloud and Quantum Computing - Database Trends and Applications

Budget 2020: Focus on AI, ML, IoT and Quantum Computing will provide a boost to digital economy – Express Computer

With a huge focus on Internet of things (IoT), machine learning (ML), artificial intelligence (AI) and analytics, India Inc believes that the budget will provide a boost to the countrys digital economy

We present below some industry reactions from different firms:

Ashwin Kumar, Director, Data Centre and Cloud Operations, Linode IndiaWith a focus on technology and innovation, Budget 2020 sets the foundation for Indias future. The allocation of INR 3000 crore for skills development will help bridge a sizable technological skills gap in the country and enhance the global competitiveness of small and mid-size businesses throughout the country, which today employ 40 percent of Indias total workforce and contribute nearly 30 percent to the Indias economy. We welcome all efforts that positively drive the key levers of modern business innovation, growth and efficiency.

Sunil Sharma, managing director sales, Sophos India & SAARCThe Governments Union Budget 2020 is built on the bedrock of emerging technologies including Artifical Intelligence (AI), Machine Learning (ML), Internet of Things (IoT) and more. Initiatives such as building data center parks across India aiming to safeguard data, the most critical asset of organisations along with the digitisation of 100,000 Gram panchayat through its Bharatnet initiative will strengthen the digital fabric of the country. However, increased digital penetration brings along with it cybersecurity risks. As per a recent report, Indian IT managers detected 39% of threats on servers, 35% on the network, 8% on endpoints and 18% on mobile. Additionally, 90% of IT managers believe cybersecurity awareness and education among employees is a major challenge for organisations. That said, while we welcome the Governments proposed steps in strengthening the MSMEs that provide employment to millions of people, we need more impetus on building skilled cybersecurity professionals in the country. The governments allocation of Rs. 3,000 crore towards skill development is a step in the right direction towards building Indias youth and economy. Sunil Sharma, managing director sales, Sophos India & SAARC

Hemal Gathani, Co-founder of Zeux InnovationTwo messages stand out from todays Union Budget address for companies like us. One, the commitment being demonstrated by the Government to emerging technologies and initiatives being taken to improve the ecosystem be it in terms of setting knowledge or technology clusters or announcing a National Mission on Quantum Technologies. Having relocated from US to start a company here, we are thrilled with the governments resolve on this issue. Two, trying to do their bit in creating more stable start-ups by resolving issues such as tax relaxation on ESOPs. Although much more is still to be done jumpstart the economy, but steps such as these will surely help stem the fall and lay new ground for growth.

Government is walking the talk to make India a leading startup hub in the world. Government has announced numerous benefits for all the key stakeholders in the startup space Employees, Investors & Promoters etc. This will go a long way to make India the preferred destination for startups.

Sandeep Bhambure, Vice President and Managing Director, India & SAARC, VeeamThe governments announcement of setting up a policy to build data centre parks throughout India for digital connectivity and the allocation of Rs 6,000 crores for BharatNet is a big step towards a successful Digital India initiative. This will increase the adoption of technologies such as IoT, Analytics and AI; leading to an unprecedented amount of data generation. Data management and protection will play a key role to safeguard the citizens data from cyber-breaches. Additionally, the implementation of intelligent data management platforms will help achieve positive outcomes from the data.

Yadvendra Tyagi, Co-Founder of EnKashBudget 2020-21 has been extremely startup-friendly on various accounts, including the fact that turnover limit for a company to qualify as a Startup and enjoy special tax benefits has been generously raised to 100 Crores, from the previous 25 crores. The budget has also met the expectations of Startups with respect to the lowered corporate tax rate of 22% being maintained. This has a direct bearing on a business like ours, as it will restore the spending/purchasing capacity of businesses, especially the MSMEs to some extent, which is one of our key value propositions at EnKash (We offer Corporate Cards designed especially for Startups, called Freedom Card). For growth stage startups that are currently in the process of raising funds or in talks with foreign investors, the governments proposition to eliminate Dividend Distribution Tax (DDT) will be an impetus for investment and the consequent scale-up. Additionally, the audit threshold for MSMEs that has been raised to Rs. 5 Crores from Rs. 1Cr is also going to be a huge enablement for young businesses, and we welcome this move with open arms.

Relief in personal income tax rate across the board too is a historic step towards the revival of Indias economy at a time when the whole country, i.e. both businesses and individuals have been facing financial strain. Other initiatives such as deferring ESOP taxation to 5 years is also going enable young business to continue offering stock options to deserving team members without them having to worry about selling the shares immediately. Finally, streamlining GST infrastructure and introducing automated processes as promised, will help ensure tax compliances for companies that operate with limited resources.

Naveen Chava, CEO, IDSignWith todays union budget themed around three strong aspects- Aspirational India, Economic Development and Caring Society, the Government of India has reassured its promise in promoting the Indian startup ecosystem for a vibrant and inclusive economy. The proposals aimed at bringing fundamental structural reforms and digital governance such as setting up investment advisory cell online to help young entrepreneurs with faster clearance and launch of seed fund to support early-stage startups come as a major booster for the sector. The decision to relax much-awaited Esops is a laudable move which will now help startups to attract new talent pool. Additionally, the allocation of 3000 crore for development of skill India programme testifies the governments urge to embrace the proliferation of future-readying technologies- Analytics, IoT, AI Quantum Computing and so on among rural youths to make them part of digital India. Also, the governments step to mandate aadhaar-based verification on indirect taxes would certainly widen lucrative business opportunities for companies like us operating in the area of digital signing and verification management

Leon Yu, Regional Head, India & South Asia, Asus

At Asus, we believe that the Union Budget 2020 announcement has covered several pressing issues faced by the economy and is going to bring growth opportunities. All eyes would be on the manufacturing sector, with the FM proposing a scheme to encourage mobile phones, semiconductor packaging, and electronic equipment. The new scheme, Nirvik, is also going to offer respite for exporters, promising to settle refunds for electricity and VAT previously levied. Furthermore, the provision to bring digital connectivity to all public institutions at Gram Panchayat and allocation of INR 6,000Cr to bring fibre to home through BharatNet linking 100,000 Gram Panchayats in FY21 are also welcomed moves.

With Indias rising aspirations reaching the rural locales, internet connectivity will pave the way for connected and smart consumerism. At Asus, we shall be pursuing ways to support the government in enriching Indias economy and traversing through rural India to ensure optimum growth and development. We also look forward to the policy on private players setting up data parks and shall be offering full support with our cutting-edge products and services

Bhavin Turakhia, Founder & CEO, FlockWe are delighted with the steps taken by the Government in the Union Budget towards providing an impetus to entrepreneurship and acknowledging that startups are major job creators. This year, the budget has allocated Rs. 3,000 crore for skill development, which will help in creating a future-ready workforce. The provision for setting up an investment clearance cell for entrepreneurs, an online portal to facilitate quicker business clearances, and a seed fund to support early-stage startups will all collectively attract foreign investment in Indian startups. At present, startup employees are required to pay tax whenever they sign up for ESOPs with a vesting schedule and also pay taxes on capital gains whenever they redeem their ESOPs. As a provisionary measure to this, the minister has proposed deferring the tax payment by five years, or until employees leave the company, or when they sell their shareswhichever is earlier. Additionally, we welcome the governments move towards boosting emerging technologies such as internet of things (IoT), machine learning (ML), artificial intelligence (AI) and analytics which will provide a filip to the countrys digital economy. We believe that with all of these measures, 2020 will be a great year for the Indian startup ecosystem.

Shashank Dixit, CEO, DeskeraThere are 3 key takeaways from the Union Budget 2020 for ease of doing business and the startup community. 1. The simplified GST return system scheduled to be launched in April20 will reduce the compliance burden on SMEs. 2. The threshold for audit being raised from Rs. 1 crore to Rs. 5 crores will further provide a fillip to Indian SMEs. 3. With the abolishment of Dividend Distribution Tax (DDT), it is sure to make India an attractive investment destination

Kunal Lakhara, VP of Finance and Operations, Pocket AcesBudget 2020s revised fiscal deficit target of 3.8% of the GDP seems more realistic and focus on spends/ benefits was required to boost the economy. The thrust on entrepreneurship and tax regulations for both, startups and taxpayers is a move in the right direction. India is the third largest startup hub globally and the announcement of an investment clearance cell to provide end-to-end support to startup founders will encourage more youth to be job creators. Further, the ability to defer taxes on ESOPs will democratise wealth creation for startup employees, ensuring the right talent is benefitted. Finally, the decision to grant 100% tax exemptions to sovereign wealth funds on their investment in priority sectors will provide the much needed funding boost to the sector and create value in the longer run.

Redickaa Subrammanian, Co-founder and CEO, ResulticksDigital disruption has transformed Indias business landscape and the announcement for building more data center parks will further aid in laying a strong foundation for a digitally connected country. INR 8000 crore allotment for developing quantum technology is impressive, and this in tandem with the grassroots level skilling initiatives, make for a strong technology ecosystem. Engineering students will also gain real-world experience through the new internship programs, creating a digitally skilled talent pool equipped to work in a digital economy.

As a fast growing AI and ML based technology start-up, we welcome setting up of the investment clearance cell. The proposed revisions in the income tax structure should lead to increased consumer demand and provide an overall impetus for economic growth in India. The announcement made in Budget 2020 showcases the governments support for Indias technological advancement and we are excited about the entrepreneurial spirit it promotes

Chandrahas Panigrahi, CMO and Consumer Business Head, Acer IndiaThis is positive budget overall from the technology focus point of view. We are pleased that the Government is allocating Rs. 8,000 crore for the National Mission on Quantum Computing and Technology. The governments move on encouraging manufacturing of electronic equipment in India is also a big step as this would provide much needed impetus to technology and manufacturing sector, which has been developing capacities and generating employment opportunities. Also, more focus on technology such as Machine Learning, Robotics, AI will support the industry to grow and establish India as a robust ecosystem for technology and innovation

Vamsi Krishna, CEO & Co-founder, VedantuThe vision of making education accessible to the farthest corner of the country will greatly benefit students. The allocation of budget to hone the skill sets of teachers and educators will positively impact quality learning and thereby provide a boost to the education sector. Additionally, the allocation of budget to BharatNet will also have a deep impact on skilling rural India as it has the potential to open up online learning to students and professionals from remote villages. With better bandwidth internet, a qualified teacher located in a metro city can impart LIVE online classes to students in small town India, where theres a dearth of quality education. Technology will soon disrupt the entire concept of the classroom and make it an extremely personalized, one to one teaching-learning experience tailored for each mind.

Mitesh Shah, Head Finance, BookMyShowAt the onset, we would like to laud the Government for a growth-driven budget. We welcome the progressive policies aimed at encouraging rural demand, changes in personal taxes to spur consumption, impetus to infrastructure development, measures aimed at bolstering growth and reversing slowdown. Additionally, taxation related to ESOPs as a perquisite and removal of DDT are significant moves. However, it would have been beneficial to have the benefits of taxation relief on ESOPs expanded to companies and industries at various stage of growth and not be limited to startups alone.

Compliance on e-commerce has been increased by mandating them to deduct a TDS of 1% on all goods and services sold on e-commerce platforms. This would be in addition to TCS under GST and this amendment might further increase the cost of compliance for e-commerce companies. The governments vision to build data centre parks, allocation towards quantum computing and its focus on using artificial intelligence in statistical and other government departments will take Indias growth story to the next level and help further the Digital India dream.

Manish Mishra, Partner, J. Sagar AssociatesBudget focusses on providing impetus to domestic industry by rationalizing Customs duty exemptions, and levying duties on import of goods for specific industries which are focused on Make in India including increase on customs duties on electric vehicles. Government has taken steps to ensure measures to curb abuse of benefits available under the preferential / free trade agreements harming the domestic players. Keeping this theme in mind safeguard duty and anti-dumping duty has also been imposed on specific sectors.

Health cess of 5% in the nature of customs duty has been levied on import of specified medical devices with immediate effect.

From a GST perspective, given that GST Council along with the government has been taking steps to improvise implementation and administration of GST on an ongoing basis, no surprises or key amendments have been made to the GST legislation. Amendments for extending composition scheme to services sector and in the transition provisions for enabling the government to prescribe time limit for claiming unclaimed credits under the erstwhile regime is a positive step by the government

Yashash Agarwal, CEO, GamezopFMs proposal of delaying tax collection on the exercise of ESOPs is a welcome move. The current structure looks to collect taxes too early causing employees to not exercise vested shares. Easing direct taxation for eligible startups will encourage businesses to chase the right metrics and not just growth at the by bleeding money. The definition of eligible startups must be broadened to bring more companies in this fold.

Rakesh Kharwal, Managing Director, India/South Asia & ASEAN, CyberbitThe government has highlighted the role of digital technologies like analytics, IoT, AI, and quantum technology during this Budget Session. The burgeoning digital infrastructure of India needs a strong cybersecurity framework to support it. Now, since it has allocated Rs. 99,300 crores to the education sector and Rs. 3,000 crores for skill development itself, a good way to realize Indias digital vision could be by working on the cybersecurity front from the very beginning. The government may want to cover its tech initiatives with avant-garde simulation-based cybersecurity training platforms like Cyber Range for proposed cyber forensic university and Skill India campaign. This will help India in generating millions of jobs for the youth and also strengthening national security

Sanjay Katkar, Joint Managing Director and Chief Technology Officer, Quick Heal Technologies LimitedFor cyber forensics University One major step announced by the FM involved the proposal for establishing a national forensic university and cyber forensic university. With cyber crimes increasing at a rapid rate, the need for cyber forensics has become more important than ever for a rapidly digitising country like India. The setting up of a cyber forensics university is a welcome move from the Government. This will definitely help in improving Indias expertise to solve complex cyber crimes

Mike Chen, General Manager, TCLAt TCL, we believe that the Finance Minister has announced an encouraging Union Budget 2020. Proposing the scheme to encourage the manufacturing of mobile phones, semiconductor packaging and electronic equipment is a welcomed move and we look forward to a complete policy and leveraging the same to kickstart the domestic manufacturing through our panel factory in Tirupati. Furthermore, painting a futuristic picture in this years budget announcement, the FM also acknowledged advanced technologies like IoT, AI, and analytics changing the world. At TCL, we are forever committed to advancing our AI x IoT ecosystem in India and will continue to invest in cutting-edge technologies to offer the best services to our customers in India.

Rahul Sharma, MD-India, LogMeInBudget 2020 looks very promising. We are particularly enthused about the FMs announcement of seamless delivery of digital services as part of the next wave of digital revolution. AI, ML, Analytics, IoT, Robotics are making giant inroads in India, as was observed in the budget. The policy being introduced to build data centre parks throughout the country will help enhance the digital infrastructure to a significant extent. We are looking forward to the next phase of Digital India which will be a big growth driver for businesses and individuals alike.

Aakrit Vaish, CEO, HaptikAs digitization and advanced technologies continue to gain momentum, we welcome the Budget 2020 announcements. Once again, the Finance Ministers emphasis on machine learning, robotics, AI and IoT will help boost Indias digital journey. A significant proportion from the allocation of INR 3000cr for skill development should focus on these cutting-edge technologies. We are also delighted to witness proposals such as the linking of 100,000 Gram Panchayats through the enhancement of Bharat Net and setting up of data centre parks across the country. As national systems become more sophisticated and our workforce is equipped with the relevant skills, we will truly see the next wave of digital revolution, with greater scope for large-scale indigenous innovation

Suganthi Shivkumar, Managing Director, ASEAN, India & Korea, QlikWe appreciate the governments decision in the 2020 Budget to dedicate the necessary funds and resources towards developing revolutionary and breakthrough technologies such as ML, robotics and AI to further the skills that will prepare us for the next wave and accelerate Indias journey towards becoming a digital giant. With data equated as the new oil, the governments plan of building cutting-edge data parks across the country is equally important. Furthermore, the governments initiative of allocating Rs 6000 crores to enable unabridged digital connectivity in over 100,000 Gram Panchayats through the Fiber to Home BharatNet scheme holds brilliant potential in securing Indias passage towards achieving tech-empowerment for the remote sector.

Piyush Kumar, Founder & CEO, RooterIts very encouraging to see that Indian Government regards entrepreneurship as strength of India. Start-ups can not only get a lot of foreign investment in India but also create thousands of jobs. The investment clearance and advisory cell for entrepreneurs is a great step to encourage new entrepreneurs and provide assistance. Moreover, the seed fund to support early-stage start-ups will help them to create quality market fit product before approaching VCs

Akash Gupta, Founder and CEO Zypp (Earlier known as Mobycy)The Union Budget 2020 paints an affirmative picture for the future. We are glad that the Finance Minister has emphasised on improving the air quality, citing that the matter of clean air is a matter of concern in large cities that have a population of over 1 million. To the same end, we believe that EV-powered everyday commuting solutions offered by Zypp through Electric Scooters and Logistics solutions will play a crucial role in times to come. The budget announcement further comprises positive news for Indias fast-growing start-ups. The proposal to set-up investment clearance cell for entrepreneurs along with assistance in funding would definitely prove to be extremely beneficial. Furthermore, increasing the threshold of start-ups eligible for tax deduction from an annual turnover of 25Cr to now up to 100Cr is another welcomed move. The FM has also increased the window for such start-ups to claim a tax deduction for 3 years out of 10 years now as compared to 7 years previously. Owing to the same, the start-ups will find it easier to take risks and not be burdened financially while pursuing trailblazing innovations. Deferring ESOPs for start-up employees is another affirmative move, giving employees of start-ups to postpone taxation for 5 years or whenever they exit the venture, whichever is earlier.

Ambika Sharma, Managing Director & Founder, Pulp StrategyThe latest budget announcement for the year 2020 -21 bears vast potential in shaping Indias road towards achieving its target of emerging as a 5 trillion dollar economy. With India currently posed as the fifth largest economy in the world, I am particularly enthralled by the governments decision to optimize new-age disruptive technologies such as Machine Learning, robotics and Artificial Intelligence (AI) towards attaining a seamless and integrated service sector. Further advancing the digital revolution in the country is the governments resolution of developing state-of-the-art data centers across the nation. Moreover, the FMs proposal to allocate Rs 6000 crore for connecting 100,000 Gram Panchayats by FY21 will also prove instrumental in accelerating Indias journey towards becoming a tech enabled nation. Also admirable is the governments successful implementation of the Beti Bachao and Beti Padhao scheme which was reflected by the high gross enrollment of girls in all levels of school education. With the budget modeled towards realizing a progressive and equal women-centric society, the Finance minister also highlighted the fact that presently more than 6 lakh Anganwadi workers are equipped to upload status of more than 10 crore households. The governments decision to provide Rs 35,600 crore for nutrition related programs and Rs 28,600 crores for women linked programmes will vastly help in furthering women empowerment and gender equality

Abhishek Kumar, Regional Director, Onvu TechThis years budget includes a number of positive reforms for the surveillance and security agency. The government has announced the launch of Police Academy and Forensic Sciences, 5 more smart cities, 9,000 KMs of economic corridor, enhancement of tourist attractions, and improved business landscape for MSMEs alongside others. Security and Surveillance infrastructure is a core element of all of these reforms and will give a strong stimulus to the segment

Abhishek Kumar, Regional Director, Onvu TechThe government has announced a number of measures for the education sector with a whopping Rs. 99,300 crore budget. With it, courses will go online soon and Top-100 NIRF Ranked Institutes start offering them. The government has also announced positive reforms including Asian-African Study in India program, establishment of Police Academy and Forensic Science, and integration of medical institutes with dist. hospitals. Rs. 3000 crores have further been allocated for Skill Development. Perhaps, all of these reforms will go a long way by including video-analytics-based EdTech solutions to them as well

Raman Singh, Chief revenue officer, Cloud ConnectAt CloudConnect, we wholeheartedly believe that the progress of the country lies in creating more opportunities for start-up owners. Thus, we duly welcome the decisions taken by FM Nirmala Sitharaman through the Union Budget 2020. She has rightly mentioned that entrepreneurship is the true spirit of India and has been its strength.We appreciate the governments emphasis on promoting cutting-edge technologies such as machine learning, robotics and AI in India. The commitment to tech-advancement to support entrepreneurship is evident in the governments decision of building data center parks throughout the country and proposing INR 8,000Cr for over 5 years for the National Mission of Quantum Technology and Application.

Finally, the setting up of investment clearance cells and portals for entrepreneurs in order to assist them in funding will give a significant boost to entrepreneurship in India.

Ravi Goyal, Chairman & MD, AGS Transact Technologies LtdThe removal of dividend distribution tax will reassure the flow of FDI and make Indian equities more attractive. This years budget focused on entrepreneurship and early stage start-ups and the FM has provided a series of measures, that will encourage Indian start-ups whilst focusing on positioning entrepreneurs as job creators. The overall focus on boosting transport infrastructure will help pursue greater commercialization of highways to raise finance operating road assets. Recent developments to promote digital payments such as zero MDR are pre budget announcements and there was an expectation of a clear roadmap from the government on supporting digital payments infrastructure given the sector will be a major catalyst towards achieving the $5.5 trillion target.

Forward Looking Budget Focused on Technology and Infrastructure: IAMAI

New Delhi, 01 February 2020: The Internet and Mobile Association of India (IAMAI) has welcomed the positive outlook on the digital industry and the push to improve digital infrastructure. IAMAI believes the announcement made by the Honourable Minister of Finance Smt. Nirmala Sitaraman will promote entrepreneurship, and will boost investments. Subho Ray, President, IAMAI said: The focus on Technology and Digital Infrastructure is a step towards realizing the trillion-dollar economy and will open up new opportunities for demand generation.

According to IAMAI, the vision to provide digital connectivity to all public institutions at gram panchayat level in FY 21, is ambitious and will usher in the much-needed digital revolution under the Digital India initiative, and will also help in the last mile connectivity. This will also bridge the Rural-Urban digital divide, and will open avenues to jobs and employment creation. According to IAMAI, the budget duly acknowledges the positive role of emerging technologies such as AI, IoT, Quantum Computing, in the new world economy.

IAMAI has also welcomed the finance ministers proposal for promoting the manufacturing of mobile phones, electronics, and semiconductor packaging in the country. In her speech the minister said that India needs to boost domestic manufacturing and attract investment in electronics manufacturing.

IAMAI has maintained that India should focus on attracting large-scale manufacturing and enhance local value integration, and also rapidly capture the markets for high-end smartphones. According to IAMAI, Government must, therefore, provide both productions-based incentives as well as export-oriented incentives to encourage Indian domestic manufacturing. As the Finance Minister rightly said, There is a cost advantage for electronics manufacturing in India.

IAMAI also welcomed the Ministers assurance that there will be an effort to create more opportunities for startup owners. The proposal to set up of Investment clearance cell for entrepreneurs and offering assistance in funding is a welcome move.

IAMAI has also welcomed the plan to provide online quality education to deprived section of society. The association feels that the step will provide the much-needed fillip to the online education sector and will also help in providing quality education in the rural areas.

Priya Mahajan, Head of APAC Public Policy & Regulatory Counsel, Verzion Enterprise SolutionsThe Union Budget 2020, is encouraging , forward looking and would ensure the necessary boost to the Digital India Vision. The Budget duly recognises the transformational impact of emerging technologies such as AI, IOT, Big data, Cybersecurity, ML and Robotics on the economy . The digital growth momentum is steered further and India definitely has a key role to play in the global economy and future of technology and innovation. We believe that India has a unique success story and a step towards being a global technology leader. This budget definitely favours new age digital economy and we look forward to further growth in the sector

Nikhil Arora, VP and MD, GoDaddy IndiaThe Union Budget 2020 is a reflection of the Government of Indias vision and commitment towards delivering an inclusive growth. The proposed reforms especially those focused towards MSMEs and startups such as provision of seed funding for early-stage startups and setting up of a portal based investment clearing cell, will further help to bolster growth of independent ventures in India. Big announcements like deferred payment of ESOPs, as well as the creation of an e-market place for MSMEs, are also laudable steps by the Government towards uplifting the overall entrepreneurial spirit in the country. We also believe that the proposed allocation of INR 99,300 for education and the allocation of INR 3000 for skilling initiatives, can be instrumental in delivering better educational infrastructure and innovation. As India gears up to chart the next chapter in its strong growth story, we at GoDaddy continue to work in collaboration with the Government and our partner ecosystem, to help entrepreneurs and small businesses grow their ventures online, with our easy-to-use and affordable tools and solutions

Prasanna Sarambale, CEO, Sterling & Wilson, Data Centre BusinessThe Union Budget 2020, is extremely encouraging and would ensure the necessary boost to the economy. For the first time Data centres have been given due importance. As technology leads the next level of growth for the country, the governments move to focus on building the necessary back end infrastructure (via construction of new Data centre parks through the country) will ensure the GDP gets the necessary shot in the arm that the country is looking forward too. The impetus planned by the government will ensure long term sustainable growth not only for the sector but also the country. Development of smart cities will need smart data centres, which is a huge opportunity for the sector, this move will also ensure jobs creation and boost to local consumption. This will act as a catalyst in the development of individual states

Jitendra Chaddah, Chairman, IESAThe vision for the semiconductor and electronics industry in the budget speech is encouraging. We feel this interim budget by Finance Minister is progressive and inclusive. It focuses on leveraging new technologies to build countrywide digital infrastructure, skill-building and drives growth by providing cost benefits for electronics manufacturing in India. The scheme to boost the intelligent electronics & semiconductor ecosystem by the manufacturing of mobile phones, semiconductor packaging and electronic equipment, assures more investment. We foresee the sustained incentives by the government to promote local manufacturing will fulfil local demand and also enable India to become an export hub for electronics

Sudhindra Holla, Director, Axis Communications, India and SAARCThe budget set by the Finance Minister is focusing directly on three factors, namely Aspirational India, Economic Development, and a Caring Society. Delving into these three aspects, it has kept a keen eye on improving the transport and infrastructure by allocating Rs 1.75 lakh crore for these sectors. Furthermore, we support the keenness to develop more smart cities by allotting 5 new smart cities under the PPP model. With 100 new operational airports and high-speed trains both the aviation and railways will now see redevelopment programs to enhance the passenger travel experience. The idea of 100% exemption for sovereign wealth funds in infrastructure and other notified sectors with a minimum lock-in of three years is welcoming. We view it as a definite budget for the corporates who are driving the countrys growth and infrastructure development in both Tier 2 and Tier 3 cities

Sashi Kumar, Managing Director, Indeed IndiaData from Indeed reveals that technology-related job roles in India are among the most promising for job seekers, as these job openings have grown consistently in the past five years. Last year alone saw tech job roles grow by 31%. Despite ups and downs, hiring is stabilizing as companies shift gears to skill their workforce. The proposition to provide internship opportunities for young engineers at urban local bodies is a very good move in helping young talent make good use of their qualification and scale from there.The onus of creating a culture of learnability and skilling that can ensure sustained employment is now shifting to the industry. Companies need to invest strongly in L&D initiatives that can help their employees stay industry relevant in the race to profitability. In fact this could be a positive move towards employee loyalty and retention that can in-turn help organisations find sustainable growth

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Budget 2020: Focus on AI, ML, IoT and Quantum Computing will provide a boost to digital economy - Express Computer

New Quantum Switch Turns Metals Into Insulators by Altering the Quantum Nature of the Material – SciTechDaily

This is an artists impression of the dissolving of the electronic traffic jam. The red atoms are different in their quantum nature and allow transport of electrons in their surroundings. Credit: SBQMI

Most modern electronic devices rely on tiny, finely-tuned electrical currents to process and store information. These currents dictate how fast our computers run, how regularly our pacemakers tick and how securely our money is stored in the bank.

In a study published in Nature Physics on January 27, 2020, researchers at the University of British Columbia have demonstrated an entirely new way to precisely control such electrical currents by leveraging the interaction between an electrons spin (which is the quantum magnetic field it inherently carries) and its orbital rotation around the nucleus.

We have found a new way to switch the electrical conduction in materials from on to off, said lead author Berend Zwartsenberg, a Ph.D. student at UBCs Stewart Blusson Quantum Matter Institute (SBQMI). Not only does this exciting result extend our understanding of how electrical conduction works, it will help us further explore known properties such as conductivity, magnetism, and superconductivity, and discover new ones that could be important for quantum computing, data storage, and energy applications.

Broadly, all materials can be categorized as metals or insulators, depending on the ability of electrons to move through the material and conduct electricity.

However, not all insulators are created equally. In simple materials, the difference between metallic and insulating behavior stems from the number of electrons present: an odd number for metals, and an even number for insulators. In more complex materials, like so-called Mott insulators, the electrons interact with each other in different ways, with a delicate balance determining their electrical conduction.

Measurement of a material where modification of the spin-orbit coupling has been used to make it electronically conductive. The dark colors represent electrons that are free to move through the material, and are an indicator of the conductive behavior. Credit: Berend Zwartsenberg/SBQMI

In a Mott insulator, electrostatic repulsion prevents the electrons from getting too close to one another, which creates a traffic jam and limits the free flow of electrons. Until now, there were two known ways to free up the traffic jam: by reducing the strength of the repulsive interaction between electrons, or by changing the number of electrons.

The SBQMI team explored a third possibility: was there a way to alter the very quantum nature of the material to enable a metal-insulator transition to occur?

Using a technique called angle-resolved photoemission spectroscopy, the team examined the Mott insulator Sr2IrO4, monitoring the number of electrons, their electrostatic repulsion, and finally the interaction between the electron spin and its orbital rotation.

We found that coupling the spin to the orbital angular momentum slows the electrons down to such an extent that they become sensitive to one anothers presence, solidifying the traffic jam. said Zwartsenberg. Reducing spin-orbit coupling in turn eases the traffic jam and we were able to demonstrate a transition from an insulator to a metal for the first time using this strategy.

This is a really exciting result at the fundamental physics level, and expands the potential of modern electronics, said co-author Andrea Damascelli, principal investigator and scientific director of SBQMI. If we can develop a microscopic understanding of these phases of quantum matter and their emergent electronic phenomena, we can exploit them by engineering quantum materials atom-by-atom for new electronic, magnetic and sensing applications.

Reference: Spin-orbit-controlled metalinsulator transition in Sr2IrO4 by B. Zwartsenberg, R. P. Day, E. Razzoli, M. Michiardi, N. Xu, M. Shi, J. D. Denlinger, G. Cao, S. Calder, K. Ueda, J. Bertinshaw, H. Takagi, B. J. Kim, I. S. Elfimov and A. Damascelli, 27 January 2020, Nature Physics.DOI: 10.1038/s41567-019-0750-y

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New Quantum Switch Turns Metals Into Insulators by Altering the Quantum Nature of the Material - SciTechDaily

Could Photonic Chips Outpace the Fastest Supercomputers? – Singularity Hub

Theres been a lot of talk about quantum computers being able to solve far more complex problems than conventional supercomputers. The authors of a new paper say theyre on the path to showing an optical computer can do so, too.

The idea of using light to carry out computing has a long pedigree, and it has gained traction in recent years with the advent of silicon photonics, which makes it possible to build optical circuits using the same underlying technology used for electronics. The technology shows particular promise for accelerating deep learning, and is being actively pursued by Intel and a number of startups.

Now Chinese researchers have put a photonic chip to work tackling a fiendishly complex computer science challenge called the subset sum problem. It has some potential applications in cryptography and resource allocation, but primarily its used as a benchmark to test the limits of computing.

Essentially the task is to work out whether any subset of a given selection of numbers adds up to a chosen target number. The task is NP-complete, which means the time required to solve it scales rapidly as you use a bigger selection of numbers, making it fundamentally tricky to calculate large instances of the challenge in a reasonable time using normal computing approaches.

However, optical computers work very differently from standard ones, and the device built by the researchers was able to solve the problem in a way that suggests future versions could outpace even the fastest supercomputers. They even say it could be a step on the way to photonic supremacy, mimicking the term quantum supremacy used to denote the point at which quantum computers outperform classical ones.

The chip the researchers designed is quite different from a conventional processor, though, and did not rely on silicon photonics. While most chips can be reprogrammed, the ones built by the researchers can only solve a particular instance of the subset problem. A laser was used to etch the task into a special glass by creating a network of wave-guides that channel photons through the processor as well as a series of junctions that get the light beams to split, pass each other, or converge.

They used a laser and series of lenses and mirrors to shoot a beam of light into one end of the processor, and a light detector then picked up the output as it came out the other side. The network of channels is designed to split the light into many different beams that explore all possible combinations of numbers simultaneously in parallel.

The team created two chips designed to solve the problem for sets of three and four numbers, and they showed it could do both easily and efficiently. Problems that small arent especially tough; you could probably do them on the back of an envelope, and conventional chips can work them out in fractions of a nanosecond.

However, the researchers say their approach could fairly simply be scaled up to much bigger instances of the problemand thats where things get interesting. For their approach, the time it takes to compute is simply a function of the speed of light and the longest path in the network. The former doesnt change and the latter goes up fairly gradually with bigger problems, and so their calculations show computing time shouldnt shift much even scaling up to far bigger problems.

Conventional chips have to do a brute-force search of every possible combination of numbers, which expands rapidly as the problem gets bigger. The groups calculations suggest that their chip would surpass a state-of-the-art Intel i7 CPU at a problem size of just six, which they think they should be able to demonstrate in their next experiment. Their estimates also predict their approach would overtake the worlds most powerful supercomputer, Summit, at a problem size of just 28.

Obviously, the proof is in the pudding, and until theyve built much larger chips its hard to predict if there might be unforeseen roadblocks. The fact that each chip is bespoke for a particular problem would seem to make it impractical for most applications.

While there is some prospect of mapping real-world problems onto subset problems that could be solved in this way, its likely any practical application would use an alternative chip design. Butthe researchers say its a great demonstration of the potential for photonic approaches to vastly outstrip conventional computers at some problems.

Image Credit: Image by Thomas-Suisse from Pixabay

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Could Photonic Chips Outpace the Fastest Supercomputers? - Singularity Hub

Healthy Living: Heart month, signs and symptoms – Q13 News Seattle

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SEATTLE, Wash. -- February is American Heart Month. Cardiovascular disease is the number one killer in men and women. Heart disease doesnt happen just to older adults. It is happening to younger adults more and more often. Now is the perfect time to learn about your risk for heart disease and the steps you need to take now to help your heart.

Dr. Mariko Harper is a Cardiologist with Virginia Mason and she helps us navigate heart health-- From the signs and symptoms to how women are more susceptible.

Heart diseaseand the conditions that lead to itcan happen at any age. High rates of obesity and high blood pressure among younger people (ages 35-64) are putting them at risk for heart disease earlier in life. Half of all Americans have at least one of the top three risk factors for heart disease (high blood pressure, high cholesterol, and smoking).

Visit http://heart.org for resources and information about cardiovascular disease.

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Healthy Living: Heart month, signs and symptoms - Q13 News Seattle

TMCx names 19 startups to be considered for 2020 cohort – InnovationMap

Everything is different when money is on the line, and a Houston startup is using financial incentives as a motivator for its users to make smart, healthy lifestyle changes to enhance their wellness.

Healthiby, a cost-effective wellness program, is changing the game of health solutions by addressing chronic and pre-chronic conditions through innovative prevention and management methods, all incentivized by both short-term and long-term financial benefits.

"Healthiby incentivizes and empowers people to achieve better health outcomes in a team context," says Mary Beth Snodgrass, managing director and co-founder. "We're different from other wellness solutions because we're focused on changing habits, as well as incentivizing better health outcomes, providing both immediate and long-term rewards."

The company launched in May 2019 and is still in its pilot stage. Snodgrass and co-founder Dr. Tristan Hartzell, a surgeon based in Nebraska, have remained committed to their foundational concept for their startup, which is to empower people on their wellness journeys and spread knowledge about the financial benefits of leading a healthy lifestyle.

Mary Beth Snodgrass (pictured) founded Healthiby with Nebraska-based surgeon Dr. Tristan Hartzell. Photo courtesy of Healthiby.

Healthiby's notion that "health is wealth" relates to the idea that engaging in a healthy lifestyle will ultimately benefit individuals financially long-term, as healthcare costs can be avoided. Essentially, Healthiby qualifies health goals as preventative measures for chronic and pre-chronic diseases. Not only does Healthiby inform its users about the long-term financial benefits of healthy living, the program introduces exciting contests in which users are eligible to win financial rewards if they meet certain health-related criteria.

In time for the start of the new year and the health-related resolutions buzz, Healthiby enacts their user-friendly digital software application, social programs, expert health advice and financial incentives to serve their goal-oriented consumers with an engaging health management regiment that is sure to keep them on track throughout the year.

"What we're really focused on this year is, in addition to our incentives, digital content and coach guidance, is making sure that participants are engaging among themselves," Snodgrass tells InnovationMap. "Science shows there are benefits to surrounding yourself with other people who share similar health goals."

In what the program's founders refer to as a "wellness rewards solution," users are able to tap into the Healthiby digital platform to track their progress, participate in social wellness groups, invest in long-term financial incentives and access digestible, cutting edge wellness literature; all components of Healthiby's "journey goals," the program's building blocks to achieving a healthy lifestyle.

"Our software application manages our contests and our rewards, but we also have a very social component, in which participants are meeting online regularly with a dietician coach," Snodgrass explains. "The reason for this is because when we're talking about chronic and pre-chronic conditions, it's important for people to have a strong understanding of how these issues affect the body and what kinds of lifestyle changes are most effective at helping people better manage or reverse them."

Photo courtesy of Healthiby

For an annual minimum of $8 each month, individual consumers have the opportunity to invest in their own long-term wellness through this interactive, user-friendly health progress program.

"Healthiby is providing a really low cost solution for people to get additional social motivation, information, and incentives so that they can stick with their goals throughout the year," Snodgrass said.

Healthiby is currently available to individual consumers in Texas, but its founders have their sights set on expanding the business and sharing their solutions to companies vested in the importance of healthy living for their employees. For now, Houston's health and wellness consumers just got richer both physically and financially when Healthiby opened its digital doors to the city.

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