As bioengineering progresses, regulation will need to follow – Highlander Newspaper

Courtesy of YouTube

The first annual conference of Please Try This at Home took place in September 2019. At the cross section of biotechnology, body autonomy and anarchy, the conference represents an inclusive group of scientists concerned with using and discussing biotechnology in the hopes of moving the field in a more progressive direction. That being said, it is indeed a solid step in the right direction, especially when one takes into consideration how misunderstood the bioengineering field has become.

To get a sense of the state of bioengineering, a biohacker by the name of Josiah Zayner livestreamed an attempt to splice his DNA to give himself bigger muscles. If it was inserted in the wrong place in his body, or in the wrong place for the code, his DNA could end up producing weakened or ineffective proteins that could affect his body functionality. While that attempt was misguided and Zayner later regretted the stunt, the implication was that this technology should be safe and easy, which is a dangerous and untrue belief to hold. As biotechnology continues to improve, more research and regulation will be needed to ensure the safety of its use.

Ensuring said safety requires a basic understanding of cellular biology, and at its core is the central dogma of molecular biology. Simply put, most genetic material is encoded in DNA, DNA transcribes to RNA and RNA translates to proteins and those proteins are responsible for most functions in the body. Generally, bioengineering works by taking a segment of foreign DNA and inserting it into the rest of the genetic code, resulting in a production of proteins that will carry out a function specific to that DNA code. The described process is extremely complex and delicate, but despite that, genetic engineering has been used to treat Parkinsons disease and sickle cell disease among others.

That said, genetic engineering has a promising future outside of simple disease treatment. To reaffirm the purpose of Please Try This at Home, genetic engineering could be used for a different form of hormone therapy for transgender individuals. In a mostly speculative procedure, a geneticist could activate the necessary genes responsible for production of a specific hormone. That being said, it is important to keep in mind that this is a hypothetical experiment, and could result in potentially greater health problems later in life. These potential problems necessitate the need for greater experimentation and regulation in order to work out the difficulties.

Experiments in gene editing on a larger scale have already been proposed to fight Lyme disease. Normally, the disease spreads when a tick bites a mouse, followed by that tick biting a human. On Nantucket Island and Marthas Vineyard, where Lyme disease is particularly virulent, a project called Mice Against Ticks is under consideration, in which mice would be genetically modified to be able to resist and prevent the spread of Lyme disease. Kevin Esvelt, the scientist spearheading this operation is also acutely aware of the potential ecological ramifications of this project, cautiously choosing an isolated island with a low human population and low chances of dispersal if the project goes awry.

Esvelts caution in choosing an experimental site calls to mind the dangers of genetic engineering: the long term effects are not yet fully known, and it is understandable to be afraid of something that is not entirely explored. The chances of cascading ecological effects from genetic engineering is as present as the possibility for abuse of genetic engineering via eugenics. Simultaneously, those possibilities are also matched by the potential to eradicate Lyme disease, malaria or leukemia.

The best way to ensure safer practices and better opportunities for the future of genetic engineering is to regulate its practice. Clear distinctions need to be made between biohackers, like Zayner and practical, controlled applications like Mice Against Ticks. Genetic engineering could have world changing effects; it just needs to be regulated and perfected.

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As bioengineering progresses, regulation will need to follow - Highlander Newspaper

A New Device that Measures the Stickiness of Tumor Cells May Improve Cancer Prognosis – DocWire News

Researchers have created a device that measures how sticky cancer cells are, which could improve prognostic evaluation of patient tumors. The device is built with a microfluidic chamber that sorts cells by their physical ability to adhere to their environment. The findings were published inCancer Research.

This new device could be the first step to better assess how likely tumor recurrence is, said Adam Engler, bioengineering professor at the UC San Diego Jacobs School of Engineering and senior author of the study in a press release. Patients with few of these aggressive cells lying dormant in their surrounding tissue may be less likely to see a tumor reoccur 5, 10, or 20 years later. Engler noted that by knowing a patients risk, follow-up treatments could be better tailored to the individual.

The device they developed includes a microfluidic chamber coated with an adhesive protein. After cancer cells adhere, they are placed in the chamber before a fluid is pushed through to detach cells. The faster the fluid moves, the higher the stress exerted on the cancer cells. The analysis led the team to another critical finding: weakly adherent cells possess a unique genetic signature that identifies them and enables them to migrate and invade faster. Comparing this signature to thousands of patients in the Cancer Genome Atlas (TCGA) database, researchers observed that patients with tumors high in this weakly adherent signature experienced tumor recurrence occurred earlier and more frequently.

First author Pranjali Beri, a bioengineering Ph.D. student in Englers lab noted that: If our mouse model shows that these cells indeed reduce cancer-free survival times, it will pave the way for substantial prognostic studies in humans with these types of solid tumors.

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A New Device that Measures the Stickiness of Tumor Cells May Improve Cancer Prognosis - DocWire News

Using Regenerative Biology To Restore Mucus Production – Technology Networks

Mucus is a protective, slimy secretion produced by goblet cells and which lines organs of the respiratory, digestive, and reproductive systems. Slime production is essential to health, and an imbalance can be life-threatening. Patients with diseases such as asthma, chronic obstructive pulmonary disease (COPD), and ulcerative colitis produce too much mucus, often after growing too many goblet cells. Loss of goblet cells can be equally devastating - for instance during cancer, after infection, or injury. The balance of slime creation, amount, and transport is critical, so doctors and medical researchers have long sought the origins of goblet cells and have been eager to control processes that regenerate them and maintain balanced populations.

Recently, a group of bioengineers at the University of Pittsburgh discovered a case of goblet cell regeneration that is both easily accessible and happens incredibly fast on cells isolated from early developing frog embryos.

Lance Davidson, William Kepler Whiteford Professor of Bioengineering at Pitt, leads the MechMorpho Lab in the Swanson School of Engineering where his researchers study the role of mechanics in human cells as well as the Xenopus embryo - an aquatic frog native to South Africa.

The Xenopus tadpole, like many frogs, has a respiratory skin that can exchange oxygen and perform tasks similar to a human lung, explained Davidson. Like the human lung, the surface of the Xenopus respiratory skin is a mucociliated epithelium, which is a tissue formed from goblet cells and ciliated cells that also protects the larva against pathogens. Because of these evolutionary similarities, our group uses frog embryonic organoids to examine how tissue mechanics impact cell growth and tissue formation.

Studying this species is a rapid and cost-effective way to explore the genetic origins of biomechanics and how mechanical cues are sensed, not just in the frog embryo, but universally. When clinicians study cancer in patients, such changes can take weeks, months, or even years, but in a frog embryo, changes happen within hours.

In this project, we took a group of mesenchymal cells out of the early embryo and formed them into a spherical aggregate, and within five hours, they began to change, Davidson said. These cells are known to differentiate into a variety of types, but in this scenario, we discovered that they changed very dramatically into a type of cell that they would not have changed into had they been in the embryo.

The lab surprisingly uncovered a case of regeneration that restores a mucociliated epithelium from mesenchymal cells. They performed the experiment multiple times to confirm the unexpected findings and began to look closely at what microenvironmental cues could drive cells into an entirely new type.

We have tools to modulate the mechanical microenvironment that houses the cells, and to our surprise, we found that if we made the environment stiffer, the aggregates changed into these epithelial cells, explained Davidson. If we made it softer, we were able to block them from changing. This finding shows that mechanics alone can cause important changes in the cells, and that is a remarkable thing.

Davidsons group is interested in how cells, influenced by mechanics, may affect disease states. The results detailed in this article may drive new questions in cancer biology, prompting researchers to consider whether certain kinds of invasive cancer cells might revert to a resting cell type based on the stiffness or softness of their surroundings.

When applying these results to cancer biology, one might ask, If tumors are surrounded by soft tissues, would they become dormant and basically non-invasive? Or, If you have them in stiff tissues, would they invade and become deadly? said Davidson. These are major questions in the field that biomechanics may be able to help answer. Many researchers focus solely on the chemical pathways, but we are also finding mechanical influencers of disease.

Hye Young Kim, a young scientist fellow at Institute for Basic Science (IBS) and former member of the MechMorpho Lab, will continue this work at the Center for Vascular Research located at Korea Advanced Institute of Science and Technology (KAIST). She will study how cell motility changes during regeneration and how epithelial cells assemble a new epithelium. Davidson and his lab will explore how this novel case of mechanical cues are sensed by mesenchymal cells and how these mechanical induction pathways are integrated with known pathways that control cell fate choices.

"Frog embryos and organoids give us unparalleled access to study these processes, far more access than is possible with human organs, he said. The old ideas that regeneration is controlled exclusively by diffusing growth factors and hormones is giving way to the recognition that the physical mechanics of the environment such as how rubbery or fluid the environment - play just as critical a role."

Reference:Kim, H. Y., Jackson, T. R., Stuckenholz, C., & Davidson, L. A. (2020). Tissue mechanics drives regeneration of a mucociliated epidermis on the surface of Xenopus embryonic aggregates. Nature Communications, 11(1). https://doi.org/10.1038/s41467-020-14385-y

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Genetically engineered moths have been released into the wild to wipe out pests – KTVZ

Genetically modified diamondback moths designed to wipe out wild pest populations were released in fields for the first time in New York state.

Diamondback moths are migratory pests found in the Americas, Europe, New Zealand and Southeast Asia, but especially in areas where crops can be grown yearround.

In these parts where its not too hot nor too cold are where diamondback moths cause the greatest problems, including billions of dollars in damages to cruciferous crops such as cabbage, broccoli, cauliflower and canola. Theyre one of the most damaging insects because of their high reproduction rate and resistance to most insecticides.

To address these problems in a sustainable, environmentally friendly way, researchers have successfully genetically engineered (GE) male diamondback moths to control the pest population of their wild counterparts, according to findings published Wednesday in the journal Frontiers in Bioengineering and Biotechnology.

Theres a lot of interest in using genetically engineered insects for controlling medically important diseases, said Anthony Shelton, lead author of the study and entomology professor at Cornell Universitys College of Agriculture and Life Sciences.

In agriculture, though, I think we can take the advantage of genetically engineered insects to control a major pest species.

The moths were engineered by Oxitec, a developer of insect biological control systems that is known for its modified mosquito releases to reduce mosquitoes that carry malaria or dengue fever.

When rearing the moths, developers incorporated what they call a self-limiting gene that makes female offspring die shortly after hatching.

Typically, tetracycline, an antibiotic used to suppress the gene, is included in the moths diet so that female moths can be produced as well.

However, when you want to release populations of males, you do not include tetracycline, Shelton said. So all the female larvae that are feeding on the artificial diet will die. And then youll just have thousands and thousands of males which you can release in the field.

In cabbage field studies in Geneva, New York (about 260 miles from New York City) the moths were marked with different fluorescent powders, released together, then captured in a trap. The GE moths behaved similarly to their wild counterparts in regard to factors that would determine their potential to suppress pests.

They traveled the same distance and survived roughly as much as their wild counterparts did, in a ratio of two modified insects to one wild type, which was remarkable because in previous programs the ratio was much higher, Shelton said.

The GE moths also competed equally to the wild moths for female mates. However, wild female moths that mate with GE moths will not produce viable offspring the self-limiting gene passed to offspring prevents them from surviving, leading the authors to conclude that with ongoing releases, pests can be suppressed in a targeted, sustainable way without using insecticides.

The GE moths would eventually have no one to mate with, which means they would decline as well and disappear from the environment within a few generations, the authors said. More releases would be needed to continue to suppress wild populations.

With a method that could largely reduce the amount of pests and insecticides needed to eradicate them, the potential impact for the growers and producers of those crops is huge, said Alton Sparks, an entomology professor in the University of Georgias College of Agriculture.

If this works and can be implemented, it would make my job a lot easier for this one specific group of crops, said Sparks. Ive been battling diamondback moths on crops in South Texas and here [in Georgia] for 32 years.

Shelton previously conducted greenhouse studies in which they had diamondback moths feeding on broccoli. They had similar findings regarding pest suppression and elimination, but they also had moths that were resistant to insecticides.

Though the field releases have been successful, the practice isnt that common, as its only been used on a few insects.

If the technology works, it has tremendous potential, but its a very small set of agriculture because diamondback moths only affect a very small group of crops, Sparks said.

There have been programs funded by the Bill & Melinda Gates Foundation and the US Food and Drug Administration that are geared toward modifying insects to fight diseases and illnesses including the ZIka virus, malaria and dengue fever.

In 2016, the FDA cleared a modified mosquito developed by Oxitec for a field trial in Florida, saying that it hadnt found any negative effect on human health or the environment.

Some of these programs have been successful: From 2013 to 2015, Oxitec released roughly 450,000 modified male mosquitoes, which reduced the overall population by about 90%.

However, modifying insects is controversial, as the long term effects are unknown.

Many experts agree that more studies are needed to determine the long term effects of genetically engineering insects and whether manipulating genes upsets natural ecological cycles.

As for concerns for human health, Shelton said that contrary to the effect of insecticides on human health and the environment, the upside for GE insects is that the process is species specific, as theyll only mate with each other.

So, its not going to affect pollinators, Shelton said. Its not going to affect biological control organisms and its not going to affect human health.

Additional, longer studies are needed to fully assess modified moths ability to suppress pests and reduce insecticide resistance.

We all live in the age of genetics, Shelton said. Whether it be looking at your family tree or genetically engineering plants, we just know so much more about the genes in insects that we can now utilize this knowledge to control the pest populations in a much more environmentally friendly way and a much more sustainable way.

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Bruins go to downtown Los Angeles to share the big potential of the very small – UCLA Newsroom

Los Angeles has a well-earned reputation as a world center for arts and entertainment but thats just one part of the picture according to Paul Weiss, UCLA distinguished professor of chemistry and biochemistry. He told a downtown Los Angeles audience that he believes that the same restless creative energy also drives the research community on campus.

Weiss was speaking as part of a new collaboration between UCLA and MindshareLA; that partnership is a key component of UCLAs commitment to share the knowledge its scholars are creating with people in communities beyond Westwood. The night served as the kickoff for a yearlong, four-event series, called Vision 2020.

We have this pressure on us here that if youre not doing something a little crazy and going out on a limb, youre not doing your job, said Weiss, a member and former director of the California NanoSystems Institute at UCLA. Its a very different environment than the typical conservative academic places that many of us have seen in our training.

Weiss, who also is a distinguished professor of bioengineering and of materials science and engineering, relates this atmosphere of ingenuity and freedom to the sometimes-surprising collaborations hes part of as a nanoscientist, connecting with everyone from neuroscientists to transplant surgeons.

The potential of interdisciplinary work involving nanoscience explorations at the scale of billionths of a meter was a theme that cropped up repeatedly during It Came from Nanospace , an evening of presentations and hands-on experiences produced by UCLA and MindshareLA. Weiss was among four from UCLA who were featured in the Feb. 1 event at the Cross Campus office space in downtown Los Angeles, to a crowd of about 275 attendees.

Weiss, who holds a UC Presidential Chair and is founding editor-in-chief of the journal ACS Nano, shared highlights of his own activities as a leader in his field, from his work while at IBM on a microscope capable of imaging individual atoms to his involvement with ambitious public research initiatives launched during the Obama era. He also discussed the part that nanoscience itself an interdisciplinary field encompassing chemistry, physics, engineering and more is playing in tackling problems in other fields.

It Came from Nanospace began with a presentation by Adam Stieg, a UCLA research scientist and an associate director of CNSI. He provided a brief and engaging history of computing, leading up to a new paradigm hes exploring in his own research with UCLA distinguished professor of chemistry and biochemistry James Gimzewski: nanoscale devices physically and functionally modeled after certain aspects of the human brain. Potential future devices based on this approach wouldnt separate processing and memory, as contemporary computers do, and as a result are expected to operate with much greater energy efficiency.

Stieg noted that such interdisciplinary work fits naturally with nanoscience.

As much as nano is a thing of scale it absolutely is it ultimately becomes something of thinking, where we have to think differently about what we expect, because things dont behave as we would expect them to at the smallest of scales, he said.

We need to expect to see the unexpected, he continued, and to think creatively about how to leverage and harness these unique properties, and in many cases that requires talking across disciplines that we normally wouldnt.

Marc Roseboro/UCLA

Attendees enjoy the It Came from Nanospace event, which combined presentations and hands-on experiences in downtown Los Angeles.

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After a musical interlude, the attendees heard from Clarice Aiello, UCLA assistant professor of electrical and computer engineering and a member of CNSI. She discussed her investigations into the quantum behavior behind chemical sensors in nature such as those that underlie birds ability to use faint signals from Earths magnetic field to guide their migration.

The question that my group and other groups are trying to answer is, Can quantum physics be established or refuted to account for relevant biological phenomena, and importantly be manipulated and controlled for technological and therapeutic advantage? said Aiello, who leads the Quantum Biology Tech Lab at UCLA, known as QuBIT.

She spoke about recent discoveries about cryptochrome, a protein found in the retinas of birds that is believed to be the key to their magnetic sense. She also provided examples of potential applications for knowledge about these kinds of quantum-based biochemical reactions: drugs that protect from the harmful effects of radiation, magnetic therapies that correct metabolic disorders and quantum computers that work at room temperature instead of requiring extreme cold.

Aiello echoed the importance of collaborations across scientific fields.

I really think that by joining forces we can actually solve a lot of more-interesting problems than if we are just restricted to our own disciplines, she said.

Attendees also enjoyed musical performances and hands-on experiences such as Noise Aquarium, an art installation by Victoria Vesna, professor of design media arts and director of the UCLA Art|Sci Center, which is a collaboration between the design media arts department in the UCLA School of the Arts and Architecture and CNSI.

The interactive installation provided participants with an immersive virtual reality trip beneath the oceans surface, where they had close encounters with enlarged projections of plankton collectively the largest source of oxygen in our atmosphere and experienced the underwater noise pollution that results from human activities such as sonar navigation and fracking.

A collaboration involving artists and scientists in Vienna, the installation uses three-dimensional scans of the microscopic plankton, as well as actual sounds recorded in the ocean. Noise Aquarium, which evolved from a linear video that has been presented to audiences around the globe, is meant to bring awareness to issues such as climate change and pollution.

MindshareLA is an event series and mecca for entrepreneurs, designers, technologists and other creative, forward-thinking Angelenos seeking inspiration and connection. It has hosted 150 events and spawned numerous successful companies and countless relationships.

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Society for the study of reproduction honors MSU scientist – MSUToday

The Society For The Study Of Reproduction, or SSR, unveiled its 2020 award winners honoring seven individuals from some of the most prestigious universities in the world who have made outstanding contributions to the scientific discipline of reproductive biology.

MSU University Distinguished Professor and associate chair of research Asgi Fazleabas, from the Department of Obstetrics, Gynecology and Reproductive Biology in the College of Human Medicine, was honored with the Carl Hartmann Award, which is the highest award given by the SSR. The award recognizes a career of research and scholarly activities in the field of reproductive biology.

Six other award recipients come from institutions including University of Michigan, Yale University and the National Cheng Kung University of Taiwan.

SSR is the worlds leading association for supporting the scientific study of reproduction by fostering interdisciplinary communication among scientists, holding conferences and publishing original, meritorious studies.

The scientific research conducted by these seven biology scientists, physicians and professors have significantly advanced the science of reproduction, fertility and development, said Saima Hedrick, executive director, SSR, Their original research on a broad range of topics in the field of reproductive biology is helping lead us toward new discoveries, more mentorship opportunities and greater professionalism in the discipline. Their work has improved the lives of millions of humans and animals."

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Society for the study of reproduction honors MSU scientist - MSUToday

Is fertility law in Ireland set to change? – BioNews

3 February 2020

I reflect with sadness on the slow pace of progress in legislating for assisted human reproduction (AHR) in Ireland. This is all the more poignant when I read the good news coming from France and the recent court decisions on the recognition of parentage for children born through surrogacy.

Under current Irish law, only a male who is biologically related to a child born through surrogacy can establish a legal relationship with the child. The second intended parent can, after two years of living with the child and parent, apply to be appointed as a guardian. Guardianship ceases when the child is 18. There is also the possibility of becoming a legal parent through a step-parent adoption application. However, the Adoption Authority of Ireland is not currently making step-parent adoption orders in circumstances where the child was conceived through AHR.

A General Scheme of the Assisted Human Reproduction Bill was published in 2017, and was followed by public consultation and a report in July 2019. It is anticipated that the corresponding Act, when published, will contain legislation regulating surrogacy arrangements that take place in Ireland. The draft does not contain any provision for the recognition of parentage in a foreign surrogacy arrangement, nor for the retrospective recognition of parentage for Irish children already born through surrogacy, leaving them in legal limbo.

Recently it was reported that the Government's Special Rapporteur on Child Protection, Dr Conor O'Mahony, was asked to review issues relating to the parentage of children born to LGBT families using donor assisted technologies, including surrogacy, and the legal position of their parents. With our forthcoming general election, it is not clear whether this review will proceed.

The Children and Family Relationships Act 2015 (CFRA) came into force in 2015, except parts 2 and 3, which will take effect on 4 May this year. These sections deal specifically with donor assisted human reproduction (DAHR) and the parentage of children born through donor conception, excluding surrogacy. This is the first piece of Irish legislation dealing with donor conception and it is far from perfect.

In the five years since the act was passed, there has been much change in this country. 2015 alone saw the referendum on same-sex marriage resulting in the Marriage Act of 2015, which legalised such unions, and the Gender Recognition Act 2015. As a result of intervening legislation and the lapse of time since enactment, the CFRA has already undergone several amendments.

Parts 2 and 3 of the CRFA are cumbersome and far from perfect.

Providing all the relevant consents and declarations have been put in place and the procedure has been carried out in an Irish DAHR facility (fertility clinic), after 4 May 2020, for the first time in Ireland, it will be possible for a second female to be registered as a parent of a child.

A donor is defined as someone who provides a gamete for use in a DAHR procedure and who does not wish to be a parent. The act lays down a list of steps that must be complied with, including checks and consent procedures and an acknowledgement of the possibility of being contacted by the child after the child reaches 18. The donation must be a known donation.

There is one serious omission, which is a great cause of concern in the LGBT community. Some female couples choose to have one partner provide the egg, and the other carries the pregnancy as a way to both having an enhanced connection to their child (sometimes called 'shared motherhood IVF'). This may be prevented by the legislation, as the egg-providing mother is not a 'donor' as defined by the act: one who does not want to be a legal parent. By contrast, the provision of sperm by a husband for use by his spouse is not classified as a donation. Irish law contains a presumption of parentage in favour of the husband.

The legislation will also allow retrospective recognition of the parentage of a child born to a female couple prior to 4 May 2020. Again, there are very strict conditions to be met: the child must have been born in the Republic of Ireland, the procedure must have taken place in a fertility clinic where such procedures are legal, and the donor must have been unknown and remain unknown at the time the court application is made. Unfortunately, there are very few couples who satisfy all the criteria.

Finally, there is the thorny question of the future for gametes currently in storage in Irish fertility clinics. There is a three-year window for the use of gametes obtained prior to 4 May 2020 subject to certain conditions, the most important of which is that the intending parent is already the parent of a child born through donor conception and the gamete to be used is from the same donor and will provide that first child with a sibling. There is no time limit for the use of embryos in storage.

A lot more work is required and while the current minister for health has taken a very active interest in this area the government is now at an end. We are going to the polls in less than a weeks' time. There is no knowing what attitude the incoming government will take to matters such as this or indeed whether legislating for and regulating fertility treatment in this jurisdiction will even be on their radar.

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Pair bonding may be the foundation of human and primate societies – ZME Science

New research into primate social structures offers insight into how human social life is organized.

Primates can develop quite complex social structures just look at ours, were primates too. But exactly what made this family of species move towards a group rather than individual lifestyle? Thats what Luca Pozzi from the University of Texas at San Antonio (UTSA) Department of Anthropology, in collaboration with Peter Kappeler at the German Primate Center-Leibniz Institute for Primate Research, set out to understand.

The duo identified pair bonding as a key transition system between solitary and community lifestyles.

The evolution of complex social systems in mammals, and more specifically in primates, is a challenging and exciting area of research. Our study shows that pair livingalthough raremight have played a critical role in it, says Pozzi.

Living as a pair represents an evolutionary puzzle in the evolution of mammalian social systems because males could achieve higher rates of reproduction if they did not bond to a single female.

Pozzi explains that social systems can work as an adaptive tool. Species need to adapt to their environmental conditions, he says, which is the same process that drives biological evolution. However, a modification of social behavior can accomplish the same goal at a much faster pace than natural selection. Among half of all primate species live in groups, he adds, while a third only form pairs; the rest (roughly one third) enjoy solitary lifestyles.

In order to understand what drives this behavioral adaptation process, which factors shape it, and how many times it occurred in the past, the team analyzed genetic data and behavioral observations of 362 primate species. The team found that the transition from a solitary way of life towards living in groups most often occurred through pair bonding. Thus, the propensity to form long-term pairs can be seen as the first step towards complex social structures, they explain.

There are two current hypotheses on the development of pair bonding, the team explains: the female spacing hypothesis and the paternal care hypothesis. The first hypothesis holds that females pursue reproductive strategies that are not limited by the number of mates but by access to resources, and that under certain conditions (such as high competition for food) females may spread out, limiting males ability to monopolize access to multiple females. The second one basically boils down to the idea that males may choose to focus on a single female because she either needs his help in raising the offspring (for protection, care, or provision) or to reduce the risk of strange males committing infanticide. Either way, the male in question enjoys greater net reproductive success even if he limits his mating opportunities. Evidence is mixed for both hypotheses, the team adds.

Up to now, the assumption was that these two hypotheses were mutually exclusive. But the team found that they were actually complimentary.

An initial ecological change led the females of a species to separate in space. Solitary males, which previously had several females living in their territory, were now only able to gain access to one female and started to invest more in their offspring to increase their chances of survival thus reinforcing pair living. A further transition to group living was made possible through an improvement of the ecological situation, which allowed related females to live in close proximity once again, and they could then be joined by one or more males.

However, the pair bond typical for humans within larger social units cannot be explained with our results, since none of our recent ancestors lived solitarily. Nevertheless, the advantages of paternal care also may have led to a consolidation of pair living in humans, said Kappeler.

The paper Evolutionary transitions towards pair living in non-human primates as stepping stones towards more complex societies, has been published in the journal Science Advances.

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Pair bonding may be the foundation of human and primate societies - ZME Science

COLUMN-Coronavirus and the impact on oil consumption: Kemp – Reuters

(John Kemp is a Reuters market analyst. The views expressed are his own)

By John Kemp

LONDON, Feb 4 (Reuters) - Oil traders are struggling to estimate the severity and duration of the hit to global consumption from the outbreak of coronavirus in China, based on evidence from previous epidemics of coronaviruses and influenza.

Medical researchers recognise three global pandemics of influenza in the course of the 20th century, in 1918/19 (Spanish influenza), 1957/58 (Asian influenza) and 1968/69 (Hong Kong influenza).

Before the advent of modern record keeping, there are other probable candidates for global influenza pandemics, including 1847 and 1889 (Report on the pandemic of influenza 1918-19, British Ministry of Health, 1920).

More recently, there have been coronavirus outbreaks in 2003 (severe acute respiratory syndrome) and 2013 onwards (Middle East respiratory syndrome coronavirus).

And there have been several influenza epidemics and pseudo-pandemics that were quickly confined, including in 1947 (U.S. service personnel in Asia), 1976 (U.S. service personnel at Fort Dix) and 1977/78 (Russian influenza).

Most influenza and coronavirus outbreaks have followed virus mutations as they have passed back and forth between human and animal hosts, which is why Chinas live animal markets have been such a high-risk factor.

By their nature, epidemics tend to spread rapidly through a susceptible population that has never encountered the virus before and has no immunity, but the rate of infections and fatalities then tends to peak and fade quickly.

Most uncontrolled outbreaks have lasted roughly three months, though in some instances there have been multiple waves, such as the three waves of influenza during the summer, autumn and winter of 1918/19.

The transmission and severity of an outbreak is largely determined by two parameters: the basic reproduction number (R0) and the case fatality rate (CFR).

The basic reproduction number is a measure of the expected number of others an individual host with the virus will infect without containment measures.

In practice, the actual transmission rate (R) may be lower than the R0. But as long as the actual value of R is greater than 1, the epidemic will accelerate, as the number of infected individuals grows exponentially.

Eventually, when enough individuals have contracted the disease, developed immunity, recovered, and are no longer susceptible, the transmission rate will decline, which is why epidemics eventually fade out.

R will eventually decline below 1 because there are simply not enough susceptible individuals left in the population for the virus to continue spreading, as many have already been exposed and died or recovered.

Containment measures aim to bring down the transmission rate more rapidly through quarantine, social distancing, cancelling public events, focusing on super-spreaders, such as healthcare workers, and intensified personal hygiene.

The case fatality rate measures the number of infected individuals who eventually die of the disease or complications, such as secondary bacterial infections.

One reason the pandemic of 1918 proved so deadly is that in an era before antibiotics many of those who contracted viral influenza went on to contract bacterial pneumonia.

In most instances, viruses tend to be most lethal to the young, the old, those with already weakened immune systems and those with underlying medical conditions.

Several million deaths around the world each year are directly or indirectly attributable to the ordinary seasonal outbreaks of influenza, most of them in higher-risk categories.

The pandemic of 1918 was unusual because a high proportion of the deaths were prime age individuals, for reasons that are still not fully understood.

Case fatality rates are difficult to estimate because the mildest cases may not be reported or recorded leading to an overestimate of mortality.

In general, there is a trade off between the reproduction rate and the case fatality rate, because the virus needs to keep its host alive long enough to transmit it to others.

The most lethal viruses tend to have relatively low transmission rates, because they kill the host too quickly, while the highly transmissible viruses tend to be less lethal, giving them more opportunity to infect other hosts.

But reproduction rates and case fatality rates are notoriously difficult to estimate accurately even after an outbreak has been controlled.

In any respiratory epidemic, the biggest impact on the economy and oil consumption comes from the containment measures, such as quarantine and social distancing, taken to bring the epidemic under control.

Some measures will be ordered by the government to deal with a public health emergency but others will be taken voluntarily by businesses and individuals concerned about limiting exposure to the disease.

Social distancing measures can have a large negative impact on both business and consumer spending as well as on manufacturing production, services provision and transportation networks.

Like the course of the epidemic, the economic impact tends to be acute rather than lasting, compressed into the space of a few weeks or months.

As the outbreak burns itself out, or is effectively controlled, the need for extreme quarantine and social distancing measures declines and activity returns to normal.

As the outbreak fades, concern about health risks is eventually displaced by commercial pressure to resume normal activities.

Businesses, employees, transport companies, schools are forced to resume near-normal activity in order to earn revenue, get paid, and pass examinations.

If a typical epidemic lasts less than 13 weeks, peaking around half-way through, the impact on economic activity is likely to follow a similar pattern.

The main exception is where the epidemic returns in multiple waves, which is unusual, but happened in 1918/19.

In London, the first wave of deaths peaked in week 28 of 1918 (with most deaths between week 25 and week 33). The second peaked in week 44 (with most deaths occurring between 42 and 51).

The third wave peaked in week 9 of 2019 (with most deaths starting in week six and ending by week 14), according to contemporary statistics compiled by Britains Ministry of Health.

The first wave was comparatively mild with only a few hundred deaths in the capital. The second was much more severe, killing 3,000-4,000 people per week at its peak. The third was somewhere in between.

In the current outbreak, the principal impact on Chinas oil consumption is likely to be concentrated in the first quarter of the year, especially in January and February.

By March and April, the number of new cases and fatalities should start to decline, and more normal business activity and oil consumption should gradually be restored.

There is likely to be some lingering impact on economic activity and oil consumption as businesses and households absorb the loss of revenue and income from the first quarter, but it should fade.

But the biggest economic and oil consumption impact will most likely be felt in the first quarter and should start to fade from the start of the second and largely have disappeared by the end of the third.

The principal risk is fresh outbreaks in other centres in China or overseas, with a second or third epidemic wave later in the year, which would magnify the economic and oil consumption impact.

Chinas oil consumption averaged around 14.5 million barrels per day (bpd) in 2019, according to the U.S. Energy Information Administration (Short Term Energy Outlook, EIA, Jan. 14).

For the sake of illustration, if coronavirus depresses Chinas consumption by 10% on average in the first quarter, 2% in the second quarter and 1% in the third, the total impact will be the loss of around 450,000 bpd on average in 2020.

BPs chief financial officer said on Friday that coronavirus could reduce oil consumption by about 300,000-500,000 barrels per day, roughly 0.5% of global oil demand, which is in line with this guesstimate.

China, together with India, has accounted for more than 50% of global incremental oil consumption in recent years, so any slowdown would have a major impact on the global production-consumption balance.

Oil prices have already fallen sharply to force U.S. shale producers and the OPEC+ group of major oil exporters to implement corresponding reductions in production this year. (Editing by Barbara Lewis)

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COLUMN-Coronavirus and the impact on oil consumption: Kemp - Reuters

Are we all members of the Voluntary Human Extinction Movement? – The Outline

The other week, the Guardian Experience column, which I love because its one of very few places you can read about people being eaten by hippos in a broadsheet newspaper, published an essay by a retired supply teacher called Les Knight, who has dedicated his life to campaigning for the extinction of the human race (the title of the article is, fittingly, Experience: I campaign for the extinction of the human race).

My journey to advocating for voluntary human extinction began at school, Knight writes. As he remembers it, everywhere, throughout his childhood, seemed like it was getting too full up with people:

After a stint in the army, Knight started reading books about how overpopulation would imminently lead to food shortages and famine (a thesis soon disproved, of course, by the Third Agricultural Revolution). He joined a movement called Zero Population Growth, which wanted every couple to stop breeding after they'd had two children, and at 25 he secured himself a free vasectomy by letting a student doctor use him for practice. But eventually, Knight decided that simply limiting human population growth would never be enough: even a much smaller human population would continue to crowd and defile everywhere it occupied. And so, in the late 1980s, after settling in Portland, Oregon, Knight founded the Voluntary Human Extinction Movement. Our message is simple, he claims, we encourage people to stop procreating so the biosphere might return to its former glory, and everyone already here will be able to live life more abundantly.

The Voluntary Human Extinction Movement has never commanded anything close to mass appeal. Their main output is a newsletter called These Exit Times, which may have as few as 230 subscribers although, to its credit, it does apparently feature a cartoon strip about a voluntarily childless woman raising a bonobo.

To many, Knight's ideas must seem strange, even crazy; in opposition to everything humanity ought to hold dear. But on another perhaps even more accurate level, the message of the Voluntary Human Extinction Movement might rightly be claimed as the dominant ideology of our society and culture.

Knight himself has claimed that his movement consists of anyone who supports the idea of humanity going extinct. And it is interesting to consider what this support might plausibly consist of.

For one thing, we could count anyone, at any point in human history, regardless of VHEM membership, who subscribes in some way to Knight's views. Thus the Medieval Cathars, who believed that reproduction was a sin, were unwitting members of the Voluntary Human Extinction Movement. So too are any followers of the South African philosopher David Benatar, whose anti-natalism is premised on the intuition that it is always bad to bring a new conscious being into existence, since with existence comes the capacity to suffer. Some members of the r/childfree subreddit seem to believe that others should stop having children because it makes it more difficult for them personally to win costume contests.

Knight also appears to be willing to claim as allies people who remain voluntarily childless as a result of concerns over climate change although not wanting to have kids because you're worried about your kids carbon footprint, or the quality of life they might very well be denied in a rapidly warming world, is not the same as thinking it might be better if the whole human race went extinct. More plausibly, it seems motivated by a concern that the planet should be as liveable as possible for those who do happen to be born.

But then in addition to these people, we should probably also think to include those whose actions regardless of what they say, or think, they are doing in fact seem to be helping to bring the extinction of the human race about. (Some theoretical grounding here might be provided by Robert Pippins Hegelian, expressivist theory of intention, on which actions disclose what an agent takes herself to be doing often, indeed, to the agent herself).

And into this category of by-fruits-knowners would fall rather a lot of people, especially those people currently in power. Take the Prime Minister of Australia, Scott Morrison. Morrison might not explicitly want his country to be reduced to a permanently blazing apocalyptic hell, he might not make speeches openly in favor of bringing death and punishment to Australia. But his actions, and those of his government, are in fact working to make Australias complete devastation by climate change a lot more likely. It is a similar situation with Brazil President Jair Bolsanaro, and his enthusiasm for burning down his countrys rainforests.

But the very powerful dont only help accelerate the destruction of the planet/the human species by being cartoonish goons or villains. They also do it much more quietly, by producing structures which force us into choices that necessarily make us complicit with the death-spiral: driving cars; eating food farmed on land grown on cleared rainforests, or in monocultures that kill bees; even just going online. As Pippinian, expressivists agents do even we want everything to die?

So why would anyone, powerful or otherwise, want all conscious life to go extinct? It's worth considering what the death of all conscious life on earth would actually mean. Without anyone or anything left to experience it, the planet will yes persist. But not as the Earth not as a planet; for there will be nothing left to conceptualize it as such. Non-existence beckons.

And perhaps non-existence, in all its finality, has a certain sort of libidinal appeal. Freud, for instance, identified the death drive (or death instincts) as being one of the fundamental forces shaping our psychic lives aside from the life instincts (towards survival, sexual pleasure, and so forth), we all share the urge inherent in organic life to restore an earlier state of things, i.e. non-existence. In a sense, then, the aim of all life is death. Which can be fine, since any living species eventually has older generations die off but only if the death instincts are properly balanced with their opposites. If the death instincts ever won out completely, there would be no more life left to speak of (interestingly, Freud speaks of the death drive as a fundamentally conservative drive, which seems about right). Knight's own essay speaks of his desire for a less cluttered world, where everything beautiful beyond human life could finally thrive his own life-instincts seem to have been projected onto the non-human.

Maybe all of this is in fact motivated not by the death drive, but its opposite. Knight claims he wants all human beings now living to live life to its fullest while voluntarily choosing to wind down the human race. In a way then he doesn't really want to eliminate human life as such: What he actually wants to eliminate are future human generations.

And perhaps that's what the powers-that-be want as well. Knight is a Baby Boomer: a generation the members of whom are notorious for having material interests often starkly opposed to those of their children. What if endless, consequence-free life could be secured for all Boomers, with no pesky shape-of-things-to-come emerging to oppose it? (Was this not, in a sense, the desire behind that paradigmatic work of Boomer philosophy, Francis Fukuyamas The End of History?) Perhaps something like the sterile, polymorphically perverse utopia imagined by Michael Moorcock in his series The Dancers at the End of Time. Or the Grand Hotel Abyss Georg Lukcs described in order to zing his Frankfurt School opponents, who stayed to live comfortably complaining about the capitalist West rather than try and build communism in the East:

What if climate disaster is simply a failed attempt to secure this nihilist utopia the elimination of future generations, without yet having secured eternal life for those now living?

When one considers the extreme electoral polarization between old and young people in the UK or the US, it is possible to conclude with a sort of grim hope that the death spiral can only last so long, that eventually socialism will become the inevitable norm. But just as not all Boomers are selfish, pampered landlords who blundered their way through life riding a wave of extreme historical luck, it would seem strange to think of this utopic nihilism as being purely generational: if nothing else, Millennials were raised in a wholly Boomerfied world, and so we carry the seed of this nihilism with us.

In years to come, how might utopic nihilism continue to manifest? As forests blaze, icebergs melt, and oceans rise, will it continue to be a viable electoral force? What might the political settlement of the future be between people who actively want the human species, now perilously threatened, to be some sort of ongoing concern, and people who would be perfectly happy for it to end with themselves, just so long as they can have some fun right now?

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Are we all members of the Voluntary Human Extinction Movement? - The Outline

The aftermath of the He Jiankui fiasco: China’s response – BioNews

3 February 2020

Dr He Jiankui, who claimed that the world's first babies had been born with edited genomes, has been sentenced to three years in prison and fined for performing 'illegal medical practices' (see BioNews 977 and 1029).

In November 2018 during the Second International Summit on Human Genome Editing, Dr He shocked the world by announcing that twin girls Lulu and Nana had been born with edited DNA to make them resistant to HIV, which he had achieved usingCRISPR/Cas9 genome-editing on embryos.

Many of Dr He's peershave raised ethical questions, including the level of consentobtained from the parents of the twins and the lack of transparency surrounding his experiment. His work has been subjected to intense criticism by the global scientific community.

According to China's state-runXinhua News Agency, the Shenzhen Nanshan District People's Court sentenced Dr He to three years in jail and imposed a 3 million yuan (US$430,000) fine. Two embryologists with whom he collaboratedreceived lesser sentences; Zhang Renli was sentenced to two years in prison and fined 1 million yuan (US$143,000), while Qin Jinzhou was given a suspended prison sentence of 18 months and fined 500,000 yuan (US$71,600).

The public prosecution agency produced various types of evidence including documents, witness testimonies, electronic data, audiovisual materials and inspection records, Xinhua reported. The court held that the accused did not obtain the relevant qualifications, gained profit and had violated the national regulations on scientific research and medical management.

The nature of their transgression was consideredsevere enough toconstitutethe crime of 'illegal medical practice'. According to Article 336 of the Criminal Law of the Chinese Peoples Republic, an illegal medical practice refers to a medical activity performed by a person who does not possess a medical licence. Dr He and his collaborators' clinical trial was interpreted as a type of medical activity. As none of the three had the proper certification to practise medicine,they were found guilty of committing illegal medical practice. All three defendants pleaded guilty.

Interestingly, due process was followed in the trial. The defendants were represented by lawyers and were given the opportunity to speak during the hearing. Among those who attended the court were family members of the defendants, representatives of the National People's Congress (legislature), members of the Political Consultation Conference (official consulting body) and journalists.

In 2016, Dr He became aware of monetary gains from the technology according to the court's findings, Xinhua said. And to keep the matter confidential, he paid every couple who participated in the research 280,000 Yuan (about US$40,000), a hefty amount for most Chinese couples (or western couples). This payment and the lack of disclosure would nullify the consent given by the research subjects.

The last few decades have seen China makesubstantial economic developments and technological advances. Under premier Deng Xiaoping, its economic reform began in 1979 which opened the nation up. As the second-largest economy in the world, the Chinese government has invested heavily in genetic research.

The leading countries in genetic research include the UK, US and China. But, in terms of bioethics, China has a different culture from thedeveloped western nations.In many western societies, editing the genomes of human embryos intended for pregnancy is prohibited. For instance, the UK has had a regulatory framework governingreproductive technologies and embryo researchsince 1990.

If Dr He had been an Australian researcher, he would face 15 years in prison. There would also be sanctions from his employer and loss of research funding. Section 15 of the Prohibition of Human Cloning for Reproduction Act 2002 states that a person commits a criminal offence if they alter the genome of a human cell in a way that the alteration is heritable by descendants of the human whose cell was changed; and in altering the genome, the person intended the alteration to be heritable by descendants of the human whose cell was altered.

On a positive note, the response of the Chinese government indicates they are moving to clarifyregulation. Soon after Dr He's announcement that he had created the world's first genome-edited babies, investigators from the Guangdong Province Health Commission conducted an investigation. Its findings were that Dr He had performed the clinical trial in pursuit of fame and fortune with self-raised funds, forged ethical review documents, misled patients about the risks and breached a 15-year-old regulation that prohibitshuman embryos that have used in research from subsequentreproductive use.

In January 2019, China's President, Xi Jinping, called for stricter laws. In February, the government announced new rules on innovative technologies which would be regulated by the State Council (China's Cabinet). The National Health Commission has prohibited the three scientists from performing assisted reproduction for life and the Ministry of Science and Technology barred them from making applications for research funding. Very importantly, China's Civil Code has been undergoing amendments and its latest version, which is expected to be released in March 2020 aims to address the ethical issues raised by heritable genome editing.

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The aftermath of the He Jiankui fiasco: China's response - BioNews

Februarys Science on Tap to explore Weird, Wonderful World of Animal Sex – The Leaf-Chronicle

Brian Dunn, APSU Published 1:40 p.m. CT Feb. 3, 2020

Im about to ruin Finding Nemo for you.

Students patriciate in professor Mollie Chashners Genetics Lab on Thursday, Feb. 14, 2019. (Taylor Slifko, APSU)(Photo: Taylor Slifko)

Thats the warning Austin Peay State University biology professor Dr. Mollie Cashner had while sharing a sneak peek at Feb. 4s Science on Tap presentation: The Weird, Wonderful World of Animal Sex.

Clownfishthe type offish Nemo and his dad, Marlin, are in the movieare a good example of just how weird sex can be in the animal world.

To find out why Marlin actually should be Marlena in Finding Nemo, youll have to attend Science on Tap on Tuesday. Science on Tap happens at 5:30 p.m. on the first Tuesday of every month at Clarksvilles Strawberry Alley Ale Works.

Male praying mantises can mate even after the female has bitten off their heads.(Photo: Contributed)

Austin Peay scientists explore a different topic every month. Last month, computer science professor Dr. James Church discussed advances in facial recognition technology. Science on Tap is sponsored by the APSU College of STEM.

The freaky sex of coral, flatworms and angler fish

All animals have the ingrained desire to reproduce but doing something that sounds simplegetting two cells (the sperm and the egg) togethercan be complicated and diverse, Cashner said. Reproduction can happen in all sorts of ways.

From our human bias, we think thatthose cells somehow magically come together and then theres a stork that brings the baby, Cashner said. That may be how humans do it, but there are lots of other ways, and some of them are prettyfreaky.

Imagine youre a coral, youre literally stuck to the bottom of the ocean floor, Cashner said. How do you get your gametes (sperm and egg) to meet?

The answer might surprise you.

Cashner also will discuss how flatworms use penis fencing, how male angler fish permanently embed in females and how female damselflies deal with overly amorous males.

Female damselflies have a neat truck to deal with overly amorous males.(Photo: Contributed)

Sometimes, animal reproduction can be fatal. Attendees will learn about a marsupial that ends its life with nonstop mating and about how male praying mantises can mate even after the female has bitten off their heads.

There are all sorts of ways, and sometimes reproduction is actuallykind of scary, she said.

To learn more

Read or Share this story: https://www.theleafchronicle.com/story/news/local/clarksville/2020/02/03/februarys-science-tap-explore-weird-wonderful-world-animal-sex/4647954002/

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Februarys Science on Tap to explore Weird, Wonderful World of Animal Sex - The Leaf-Chronicle

Dill: Nutrition, Benefits, and Uses – Healthline

Dill (Anethum graveolens) is an herb thats found throughout European and Asian cuisines (1).

Also called dill weed, the plant has slender stems with alternating soft leaves and brown, flat, oval seeds. While the leaves have a sweet, grassy flavor, dill seeds are more aromatic, with a slight citrus flavor thats similar to caraway seeds.

As herb and spice, dill is commonly used to elevate the flavor of various dishes. Its often paired with salmon, potatoes, and yogurt-based sauces.

In addition to culinary uses, dill is rich in several nutrients and has traditionally been used to treat various ailments, including digestive issues, colic in infants, and bad breath (1).

This article reviews the nutritional and health benefits of dill, as well as ways to use it in cooking.

One cup (9 grams) of fresh dill sprigs provides approximately (2):

Fresh dill is very low in calories, yet a surprisingly good source of several essential vitamins and minerals, including vitamin C, manganese, and vitamin A (2).

Vitamin A is an essential nutrient that is important for maintaining vision and supporting a healthy immune system. It also plays a role in male and female reproduction (3, 4).

Similarly, vitamin C is vital for your immune system and helps with bone formation, wound healing, and metabolism (5, 6).

Additionally, it has been shown to be a potent antioxidant that helps protect your cells against damage caused by unstable molecules known as free radicals (6, 7).

Dill is also a good source of manganese. While needed in very small amounts, it is an essential mineral that supports normal functioning of your brain, nervous system, and metabolism of sugar and fat (8).

Furthermore, fresh dill provides 12% of the DV for calcium, copper, magnesium, potassium, riboflavin, and zinc (2).

However, as fresh dill is usually consumed in smaller quantities than 1 cup (9 grams), the amount of nutrients you get from sprinkling it over your food will be considerably less.

As for dill seeds, they have many similar nutritional benefits. One tablespoon (6.6 grams) of seeds provides 8% of the DV for calcium, 6% of the DV for iron, and 15% of the DV for magnesium, manganese, phosphorus, and potassium (9).

Fresh dill is low in calories, yet a good source of many essential nutrients, including vitamin C, magnesium, and vitamin A.

With its name derived from the Old Norse word dilla, which means to soothe, dill has been used since ancient times to treat colic in infants and digestive diseases, as well as to help with breastfeeding (10).

While these more traditional uses have not been supported by research, dill has been shown to have other potential health benefits.

Antioxidants are naturally occurring compounds that help protect cells against damage caused by unstable molecules known as free radicals (11).

As a result, research suggests that consuming foods rich in antioxidants may help reduce chronic inflammation and prevent or even treat certain conditions, including heart disease, Alzheimers, rheumatoid arthritis, and certain forms of cancer (11, 12)

Both the seeds and leaves of the dill plant have been found to be rich in several plant compounds with antioxidant properties, including (1, 13):

Additionally, dill is a good source of vitamin C, which has also been shown to have powerful antioxidant properties (6, 7).

Heart disease is the leading cause of death worldwide. However, the World Health Organization estimates that nearly 75% of heart disease cases could be prevented by reducing risk factors like poor diet, smoking, and lack of exercise (19, 20).

Additional risk factors for heart disease include elevated blood pressure, triglyceride, and LDL (bad) cholesterol levels, as well as chronic inflammation (21, 22).

Flavonoids, like those found in dill, have been shown to protect heart health due to their potent antioxidant and anti-inflammatory properties (23).

Furthermore, animal studies have suggested that dill extract may have cholesterol- and triglyceride-lowering effects. However, research in humans in more mixed (10, 24).

One study in 91 people with high total cholesterol and triglyceride levels found that taking 6 dill extract tablets daily for 2 months significantly improved total cholesterol and triglyceride levels but did not change HDL (good) cholesterol levels (25).

Yet, another study in 150 people with high cholesterol and triglyceride levels observed no significant changes in cholesterol or triglyceride levels after 6 weeks of daily dill tablet intake (26).

However, its important to note that most studies looking at the effects of dill on heart health have used extracts. As a result, its unclear how fresh or dried dill in your diet could affect heart health.

Overall, while the antioxidants in dill extracts may benefit overall heart health, more studies in humans are needed to assess the effectiveness of dill on cholesterol and triglyceride levels.

Having chronically high blood sugar levels is concerning as they can increase your risk of conditions like insulin resistance, metabolic syndrome, and type 2 diabetes (27).

Dill has been suggested to have blood-sugar-lowering effects (10).

In fact, several studies in animals with diabetes have shown a significant improvement in fasting blood sugar levels with daily doses of dill extract. Still, research in humans is limited (10, 28).

Monoterpenes are a class of terpenes, which are naturally occurring plant compounds that are linked to anticancer, antiviral, antifungal, and anti-inflammatory properties (1, 29).

Theyre commonly found in essential oils of plants like dill and have been associated with anticancer properties (1).

More specifically, d-limonene is a type of monoterpene that studies have shown may help prevent and treat lung, breast, and colon cancer (30, 31, 32).

As dill is high in monoterpenes, particularly d-limonene, it may have anticancer properties. However, theres currently no research on the effectiveness of dill or dill extract on the risk or treatment of cancer.

Dill may benefit your health in the following ways as well:

Dill is rich in a variety of plant compounds that may have numerous benefits for health, including protection against heart disease and certain forms of cancer. Additionally, dill may help lower blood sugar levels, but more human studies are needed.

Dill is generally safe for consumption. However, in rare cases it has been shown to cause allergic reactions, vomiting, diarrhea, an itchy mouth, swollen red bumps on the tongue, and throat swelling (10).

Additionally, its recommended to avoid dill pills or extracts during pregnancy and breastfeeding as theres limited research of their safety.

Culinary uses of dill are considered safe for most individuals, except in rare cases when it could trigger an allergic response. Additionally, women who are pregnant or breastfeeding are recommended to avoid dill pills or extracts.

Dill is a flavorful ingredient thats easy to add to your food.

Here are some ways to add fresh dill to your meals:

Dried dill can also be used to add flavor to dips, marinades, and potato, chicken, or tuna salads.

As for the seeds, dill seeds can be used whole or crushed and added to bread, soups, or vegetable dishes. They can also be used to make dill pickles.

Dill is a versatile herb that can be used in a variety of dishes, such as in a potato salad, tzatziki sauce, or over fish. Dill seeds can be used as a spice to flavor foods like pickles or bread.

To store fresh dill, you first want to lightly spritz the leaves with fresh water, wrap the sprigs loosely in a paper towel, and then place them in a zip-top plastic bag.

Store the dill in the vegetable drawer of your fridge for up to 1 week. For longer storage, you can also freeze fresh dill by rinsing and then placing the sprigs in a single layer on a cookie sheet in the freezer.

Once frozen, transfer the sprigs to a freezer-safe bag and return to the freezer for up to 6 months for best flavor.

Frozen dill can be used in cooking without thawing first. Dried dill and dill seeds should be stored in an airtight container in a cool, dark place for 6 months to 1 year (39).

When stored properly, fresh dill will keep for up to 1 week in the fridge and up to 6 months in the freezer. Dried dill and dill seeds should keep for 6 months to 1 year.

Rich in antioxidants and a good source of vitamin C, magnesium, and vitamin A, dill may have several benefits for health, including protection against heart disease and cancer.

However, its important to keep in mind that most studies looking at the benefits of dill use dill extracts. Therefore, its unclear whether dietary use of fresh or dried dill would have the same effects.

In any case, both the seeds and leaves of dill can add flavor and a pop of color to a variety of dishes. When stored properly, fresh dill can keep for up to 1 week in the fridge and several months in the freezer.

Overall, dill is a flavorful herb and spice that can add a nutritional boost to your diet.

Excerpt from:
Dill: Nutrition, Benefits, and Uses - Healthline

Sunscreen battle pits FL Republicans against Key West, Hawaii, FDA, and members of Congress – Florida Phoenix

While Republican lawmakers in Florida rush to pass legislation shielding all sunscreens from local government restrictions, the U.S. Food and Drug Administration, two Florida members of Congress, the city of Key West, and the state of Hawaii are working in the opposite direction.

Their reason: Suspicion that certain sunscreen ingredients may harm humans as well as coral reefs.

Florida lawmakers advanced bills last week to stop Key West and any other city from adopting reef safe regulations banning two specific sunscreen ingredients oxybenzone and octinoxate believed to harm corals. Preemption proponents argued the risk of skin cancer outweighs the threat to corals.

Meanwhile, the U.S. Food & Drug Administration announced that its recent studies show that 12 popular sunscreen chemicals enter the bloodstream in concentrations that no longer qualify them for listing as generally recognized as safe and effective for human use. The 12 include oxybenzone and octinoxoate. Still on the safe list are zinc oxide and titanium oxide, which are minerals.

Sen. Rob Bradley, chair of the Senate Appropriations Committee, has said he knew about the FDA findings but forged ahead with his bill preempting any limits on sunscreens. It cleared the full Senate on Wednesday (25-14) and the House health committee (10-6) the next day. It is headed for a vote in the full House as early as this week.

Those votes followed the FDA report on Jan. 21 that it no longer deems oxybenzone and octinoxate the coral-harming chemicals and 10 other sunscreen chemicals safe and effective for human use.

FDA studies demonstrated that the chemicals are readily absorbed into the bloodstream unlike their mineral-based counterparts and can no longer be designated as generally recognized as safe and effective for humans. That determination triggered the need for toxicology studies, the first ones ever done on these ingredients, which have been in use for decades.

Without further testing, the FDA does not know what levels of absorption can be considered safe, write researchers Theresa M. Michele and David Straussin a statement on the FDA website. The findings do not indicate whether absorption of the chemicals is dangerous, which is what the FDA will study next.

Here is an excerpt from theFDA report:

The available literature includes studies indicating that oxybenzone is absorbed through the skin to a greater extent than previously understood and can lead to significant systemic exposure, as well as data showing the presence of oxybenzone in human breast milk, amniotic fluid, urine, and blood plasma.

The significant systemic availability of oxybenzone, coupled with a lack of data evaluating the full extent of its absorption potential, is a concern, among other reasons, because of questions raised in the published literature regarding the potential for endocrine activity in connection with systemic oxybenzone exposure. Nearly all of these sunscreen active ingredients also have limited or no data characterizing their absorption.

Holly Parker Curry, Florida regional manager for the Surfriders Foundation, said she is appalled that lawmakers are rushing broad preemption legislation through rather than differentiating between chemical sunscreen ingredients that may harm both corals and humans and those that clearly pose no threat to either.

At Surfriders, we have repeatedly asked, Why cant we just wait until we have the FDA findings? Curry said adding that her family, which includes two children, uses mineral-based sunscreens, not chemical ones.

Bradley did not respond to requests for comment.

Meanwhile, two Florida members of Congress are pushing for reef-safe sunscreen restrictions, and lawmakers in Hawaii want to expand their own ban to include all the ingredients de-listed by the FDA.

U.S. Rep. Debbie Mucarsel-Powell, a Democrat who represents Miami-Dade and the Florida Keys, and Rep. Francis Rooney, a Republican representing Lee and Collier counties, are sponsoring HR 1834 in Congress to ban oxybenzone and octinoxate from use within national marine sanctuaries that contain coral.

The top target of their protective measure is the Great Florida Reef, where corals are dying from a variety of causes, including stony coral tissue disease, heat-induced bleaching, and water pollution.

Defending our precious coral, the species that live in and around them, and the environmental and economic benefits they provide is a necessity, and Im glad were able to work on this on a bipartisan basis, Mucarsel-Powell says in a joint statement issued with Rooney.

Reefs play a major role in preventing shore erosion and protect coastal wetlands, Rooney adds. Their preservation is a key component of our tourism-based economy. I introduced the Defending Our National Marine Sanctuaries from Damaging Chemicals Act to protect these critical areas so that they can be enjoyed and studied for generations to come. It is common sense to prevent the application of these chemicals in National Marine Sanctuaries.

Veteran corals expert Cheryl Woodley of the National Oceanic and Atmospheric Administration (NOAA) National Center for Coastal Ocean Science in Charleston, S.C., wrote in a Jan. 21 letter to Key West city officials that the evidence of coral damage due to exposure to oxybenzone and octinoxate is overwhelming, refuting claims that it is junk science.

Over 100 scientific papers in the last five to six years have shown that various chemicals in sunscreens are present in the marine environment as pseudo-persistent pollutants. They have been shown to bioaccumulate in marine biota and can have harmful effects on marine life including coral, algae, aquatic insects, mussels, crustaceans, and fish, Woodley wrote, listing the scientific papers in a lengthy appendix.

Oxybenzone threatens overall coral reef health by inducing coral bleaching; harming or killing coral larvae by inducing gross deformities; damaging DNA; and acting as an endocrine disrupter affecting reproduction and development. In fish, it acts as an estrogen-mimetic that feminizes fish. In copepods and sea urchins it slows reproduction and development.

NOAA has committed $2.5 million to coral restoration in Florida.

The state of Hawaii believes NOAA. It adopted its reef-safe sunscreen regulations in 2018, and a bipartisan group of lawmakers led by state Rep. Gene Ward introduced legislation recently to expand the restrictions to ban all sunscreen ingredients no longer deemed generally recognized as safe and effective by the FDA.

Ward told the Florida Phoenix that Hawaiis ban on reef-damaging ingredients had done no harm to the states tourism industry and that retailers embraced it, stocking their shelves with reef-safe sunscreens that contain no oxybenzone or octinoxate.

If its bad for our environment, its bad for our business, Ward said in a telephone interview. Our environment is our economy.

Ward, who serves on Hawaiis House Committee on Health, said the Democratic-controlled Legislature is confident about the science involving coral-damaging sunscreens. And because the FDA withdrew most sunscreens from its safe and effective list over human health concerns, he and other lawmakers want to ban those, too, pending the outcome of the FDA toxicology studies.

If we want to be really scientific, look at the data, Ward said. The data are not on their side.

Sen. Bradley made the same argument from the opposite side, citing undisputed evidence that sun exposure can cause skin cancer and that sunscreens reduce the risk.

He told the Senate Rules Committee that Key West leaders had been fooled by junk science and adopted feel-good measures that only give the appearance of protecting coral reefs.

Curry, with the Surfrider Foundation, and Rebecca OHara, of the Florida League of Cities, testified before the Rules Committee in opposition to Bradleys bill. They questioned why senators would not craft legislation to ban oyxbenzone and octinoxate when safe alternatives remain widely available. In particular, old-school zinc oxide and titanium dioxide, which are minerals, are considered safe for corals and remain FDA-designated as safe and effective for human use.

Bradley said he and other lawmakers are keenly concerned about Florida corals, but hold that skin cancer is a bigger threat that warrants keeping all sunscreens on Florida shelves without exception.

We are the Sunshine State, Bradley said. Florida is second in the nation for new cases of melanoma [a skin cancer]. All sunscreens should be available.

The Rules Committee approved Bradleys bill, the Florida Senate followed, and two committees in the House have done the same.

Key West Mayor Teri Johnston finds vindication for her citys sunscreen regulations within the FDA report, NOAA science, and Hawaiis actions. There is a great deal of new information coming out. This is not the end of the story, she told the Phoenix.

Bradley never discussed with her Key Wests rationale for banning the suspect sunscreens, Johnston said. We should take the lead on this. I dont know why a legislator from a land-locked district in north Florida would make this his issue, Johnston said.

Even Floridas new state-sponsored website FloridasCoralReef.org, rolled out by Gov. Ron DeSantis during a press conference on Thursday, discourages the use of chemical sunscreens.

Some chemicals commonly found in popular sunscreens have been shown to negatively impact marine life, the website says. It advises readers to avoid those and instead use sun-resistant clothing, hats, sunglasses, umbrellas, and mineral-based sunscreens.

Florida is not Florida without its coral reefs, DeSantis said, describing state and volunteer efforts to replant corals that are dying off. The volunteer efforts include Blue Force, a cadre of retired Navy Seals retrained to plant coral.

The Phoenix requested comment from DeSantis about whether he would support or veto Bradleys bill but aides had not responded as of this writing.

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Sunscreen battle pits FL Republicans against Key West, Hawaii, FDA, and members of Congress - Florida Phoenix

What you need to know about viruses – Stuff.co.nz

It is hard to open a paper or switch on the radio at the moment without being exposed to increasingly concerning updates about the coronavirus outbreak.

This WHO-declared global health emergency had infected almost 10,000 people by last Friday, and killed over 200, and is spreading far more quickly than SARS did in the early 2000s.

There are heaps of unknowns about the novel-coronavirus, including exactly where it originated from, but each day that passes will no doubt bring new information that should ultimately lead to a better understanding as to how we can stop the spread and treat those infected.

Anthony Kwan

A vaccine for coronavirus is at least 12 months away.

READ MORE:* The burden of chronic pain*Why do I get so bloated all the time?*The impact of noise

As alarming as this outbreak is, what we do have on our side is a wealth of information about viruses in general, collated over many decades, and this can inform our approach to this outbreak:

* The name virus comes from Latin, and means "poison"

* The first virus identified that could infect humans was the yellow fever virus, and was discovered by a man named Walter Reed in 1901

* Viruses are very unusual entities, being neither truly alive, nor dead, and are not actually classified as a living organism. This is because they can't survive on their own they need a host organism to be able to reproduce. Depending on the type of virus, effective hosts can be plants, animals, fungi, birds or humans. Viruses are the most abundant biological entity on the planet.

* Viruses are tiny so small in fact that they can't be detected with a normal microscope, and you could fit tens of millions of viruses onto the head of a pin. Size-wise, an average virus is between 20-300 nanometres in diameter, compared with for example an E Coli bacteria that is approximately 1000 nm across.

AP

The Novel Coronavirus (2019-nCoV) has identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China.

* They are basic structures, being made up of simply some nucleic acid (genetic material) that can be either DNA or RNA depending on the virus type, housed inside a protective shell made of protein called the capsid. The capsids of varying virus types will have very different shapes, allowing them to be quite easily differentiated by scientists. Some types of viruses also have a membrane outside the capsid called the envelope.

* The corona virus is an RNA-virus, and has an envelope. It's name comes from the Latin word for crown, as its particles have a characteristic shape reminiscent of a royal crown.

* When viruses infect their host (whether it is a plant, animal, bird or human), they effectively hijack their cells, become activated and start to reproduce, invading more cells as they go. This is the process that makes the host unwell.

* Bacteria differ from viruses in that they can survive on their own, and don't need a host to activate them. They can also be effectively inactivated, or even killed, by antibiotics which sadly have absolutely no effect on viruses whatsoever.

Viruses can cause a huge range of diseases from well-known ones such as measles, the common cold and influenza, to rarer ones that you're likely to never encounter (think Monkeypox or Kyasanur Forest disease). The symptoms caused by the infection will depend on the type of virus involved.

Some viruses, such as Ebola, lead to infections that have huge mortality rates, whilst others will trigger an illness that is barely noticeable to its host. Viruses can also have one effect on one type of host, but a very different one on another (for example, some viruses can be lethal to cats, but hardly cause any symptoms for a dog even though they may still use it as a host).

A virus's only purpose is to reproduce. Once it has achieved that in a host, the offspring of the original virus can invade new cells and new hosts this is how viral infections spread to cause outbreaks of illness. There are many different ways viruses can spread, but the exact mechanism will depend on the type of virus it is: some viruses can be transmitted from mother to unborn child, others are spread through infected faeces or blood, touch, or via sexual contact. Other types will require a "transmitter" or vector to enable them to spread, usually insects as is the case with dengue fever, for example.

Coronaviruses are actually a group of viruses, rather than just the "novel-type" (named 2019-nCoV) that is causing the current outbreak. In humans, coronaviruses typically cause respiratory infections (so illnesses affecting the lungs or airways, including our nasal passages, throats, sinuses and ears), and most of the time these are mild the virus that causes your average winter cold is a type of coronavirus. However, some coronaviruses, such as the novel-type we are seeing today and the SARS virus from 18 years ago, can be far more dangerous. Some coronaviruses can also affect chickens, leading to respiratory issues, and cows and pigs, where they can lead to diarrhoea.

Martial Trezzini/Keystone via AP

The World Health Organisation has declared coronavirus to be a global health emergency.

The newly-identified novel coronavirus seems to be able to spread from human to human, which is not the case for all viruses - it is possible that it has mutated or changed its form over the years, as viruses tend to do, to enable this to happen.

At this stage, we don't fully understand everything about this virus, but it appears to be spread by infected droplets, for example when breathing, sneezing or coughing. It is also possible that you could be exposed to the virus by touching an object that has an infected droplet on it we know that some viruses such as the 'flu virus can remain active and potentially infectious for days on inanimate objects or surfaces such as furniture or books, and it is likely that 2019-nCoV has the same capability.

As viruses aren't inactivated by antibiotics, treatment options are limited. Some drugs, known as antivirals, have been developed that can halt or slow down the reproduction cycle of the virus, and these are widely used in diseases like HIV and hepatitis where they have been life-changing.

Sadly at this stage there is no antiviral agent that is known to be effective against the novel coronavirus, though testing is happening around the world to try and identify one that will have some impact.

The most effective way to manage virus outbreaks is to prevent the spread of infection by vaccination. Vaccination programmes have had enormous impacts on morbidity and mortality around the world (the recent measles outbreak in Samoa being a stark example of what can happen when rates of immunisation drop below a certain threshold).

Some viruses, like Ebola, have a much higher mortality rate than others. Vaccination remains the most effective way to deal with a viral outbreak.

It is likely that a vaccine can be developed that will protect people from infection with coronavirus, but there is none in existence at present based on how long it takes to develop and ensure the efficacy and safety of a new vaccine, we are likely looking at 12 months minimum before one could be widely available.

Until vaccination is available, there are some simple things we can do to reduce the likelihood of spread, should cases appear in New Zealand. The most important is to recognise potential symptoms and isolate anyone thought to be carrying the virus this is crucial, but unfortunately recent reports indicate that coronavirus can potentially spread in the 10 days or so before any symptoms appear, so this will make effective "quarantine" difficult to achieve.

For all of us, maintaining really good hygiene, particularly when it comes to hand washing is important, and this applies to limiting the spread of any infection, not just coronavirus.

Focussing on our general health and resilience is important too the fitter and stronger we are, the more able we will be to fight off a virus, should we be exposed. So ensuring our bodies get good nutrition, plenty of vitamins, enough sleep, and minimising the "baddies" including alcohol and smoking, is at this stage the best way to keep ourselves well.

For more information on the coronavirus outbreak, and infections in general, visit http://www.health.govt.nz

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What you need to know about viruses - Stuff.co.nz

The Long History of the Anti-Abortion Movement’s Links to White Supremacists – The Nation

Anti-abortion protesters picket outside Florida State Prison where Paul Hill was executed in 2003 for the murder of abortion provider Dr. John Britton. (Matt Stroshane / Getty Images)

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The anti-abortion movement in the United States has long been complicit with white supremacy. In recent decades, the movement mainstream has been careful to protect its public image by distancing itself from overt white nationalists in its ranks. Last year, anti-abortion leader Kristen Hatten was ousted from her position as vice president of the anti-choice group New Wave Feminists after identifying as an ethnonationalist and sharing white supremacist alt-right content. In 2018, when neo-Nazis from the Traditionalist Worker Party (TWP) sought to join the local March for Life rally organized by Tennessee Right to Life, the anti-abortion organization rejected TWPs involvement. (The organizations statement, however, engaged in the same false equivalency between left and right that Trump used in the wake of fatal white supremacist violence at Charlottesville. Our organizations march has a single agenda to support the rights of mothers and the unborn, and we dont agree with the violent agenda of white supremacists or Antifa, the group wrote on its Facebook page.)Ad Policy

But despite the movements careful curation of its public image, racism and xenophobia have been woven into it throughout its history. With large families, due to Roman Catholic Church prohibitions on contraception and abortion, Catholic immigration in the mid-1800s through 1900s sparked white Anglo-Saxon Protestant fears of being overtaken demographically that fueled opposition to abortion as a means of increasing birthrates among white Protestant women. At the time, Roman Catholic immigrants from countries like Ireland and Italy who would be considered white today were among the targets of white supremacist groups like the Ku Klux Klan. As sociologists Nicola Beisel and Tamara Kay wrote with regards to the criminalization of abortion in the late 19th century, While laws regulating abortion would ultimately affect all women, physicians argued that middle-class, Anglo-Saxon married women were those obtaining abortions, and that their use of abortion to curtail childbearing threatened the Anglo-Saxon race.

Hostile anti-Catholic sentiment cut both ways when it came to abortion, however. Until the 1970s, pro-life activism was firmly associated with Catholics and the pope in the minds of American Protestants. This deterred many Protestants from opposing abortion as a Christian moral issuenot only in the political sphere, but even as a matter of denominational teachingbecause of its association with papists (a derogatory term for Catholics). Even the Roe v. Wade decision in 1973 decriminalizing abortion did not immediately bring conservative Protestants around. As late as 1976, the conservative evangelical Southern Baptist Convention (SBC) passed resolutions affirming abortion rights. The assumption was that it must not be right if Catholics backed it, so we havent, commented John Wilder, who founded Christians for Life as a Southern Baptist ministry in 1977 as the resistance to the pro-life movement began to dissipate.

This shift occurred in light of the lessening of anti-Catholic prejudice, strategic recruitment of evangelicals by New Right Catholic leaders, and evangelical discomfort with how many abortions took place as women accessed their new reproductive rights.

The cultural position of Catholics had shifted dramatically by the 1970s. As substantial immigration from Latin America and Asia posed a new threat to white numerical superiority, Catholics from European countries became culturally accepted as part of the white race, a readjusting of boundaries that maintains demographic control. The election of Roman Catholic John F. Kennedy as president in 1960 demonstrated how far Catholic acceptance had comeat least among liberals. Although conservative evangelical opposition to his candidacy remained rife with anti-Catholic fears, the rhetoric was less racialized and more focused on concerns about influence from the Vatican.

To counter this lingering prejudice, conservative Catholic leaders seized on the opportunity offered by the specter of atheist Communism in the mid-20th century to establish themselves as part of a Christian coalition with Protestants, unified against a common godless enemy. As Randall Balmer has written, evangelical concerns about being forced to desegregate Christian schools spurred political investment that Catholic New Right leaders capitalized on and channeled into anti-abortion and anti-LGBT opposition.

For white nationalists, meanwhile, as Carol Mason wrote in Killing for Life, Jewish people replaced Catholics as targets for groups like the KKK. Now that abortion is tantamount to race suicidenaming Catholicswhose opposition to abortion has been so keenas enemies would be counterproductive, Mason wrote. Militant anti-abortion and explicit white nationalist groups came together prominently in the 1990s when a wing of the anti-abortion movement, frustrated with a lack of legislative progress, took on a more violent character fed by relationships with white supremacists and neo-Nazis.Current Issue

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White supremacists were already participants in the anti-abortion cause, as Loretta Ross wrote in the 1990s. In 1985, the KKK began creating wanted posters listing personal information for abortion providers (doxing before the Internet age). Randall Terry, founder of the anti-choice group Operation Rescue, and John Burt, regional director of the anti-abortion group Rescue America in the 1990s, adopted this tactic in the 1990s. Terrys first wanted poster targeted Dr. David Gunn, who was murdered in 1993 in Pensacola, Florida. Gunns successor, Dr. John Britton, targeted by a Rescue America wanted poser, was killed in 1994.

The Florida-based KKK organized a rally in support of Dr. Brittons killer, Paul Hill, and Tom Metzger, founder of the racist group White Aryan Resistance (WAR), condoned the killing if it protected Aryan women and children. Burt himself was a Florida Klansman prior to becoming Christian and an associate of both killers. Fundamentalist Christians and those people [the Klan] are pretty close, scary close, fighting for God and country, Burt told The New York Times in 1994. Some day we may all be in the trenches together in the fight against the slaughter of unborn children. Members of the Portland-based skinhead group American Front regularly joined Operation Rescue to protest abortion clinics. Tim Bishop, a representative of the white nationalist Aryan Nations, said, Lots of our people join [the anti-abortion movement]. Its part of our Holy War for the pure Aryan race.

Groups like the Confederate Knights of the Ku Klux Klan trafficked in rhetoric that mirrored that of the anti-abortion movementwith an anti-Semitic twist: More than ten million white babies have been murdered through Jewish-engineered legalized abortion since 1973 here in America and more than a million per year are being slaughtered this way. Metzger has claimed that abortion makes money for Jews and called Planned Parenthood a corrupt Jewish organization. In 1996, a series of bombings in Spokane, targeting a newspaper office, a bank, and a Planned Parenthood office, were perpetrated by members of the Phineas Priesthood, who followed the white separatist anti-Semitic religion Christian Identity. In the late 1990s, Eric Rudolph, a clinic bomber, and James Charles Kopp, who murdered a Jewish abortion provider returning home from synagogue, were affiliated with the anti-abortion terrorist organization Army of God and staunch Holocaust deniers.

While in recent years, the mainstream anti-choice movement has been careful to distance itself from overtly racist and white nationalist groups and figures, embedded anti-Semitism appears in the trivialization of the Holocaust and in coded appeals to neo-Nazis. Abolish Human Abortion (AHA), a more recently founded group led by young white men (in a movement that typically likes to put female leaders at the forefront for better mainstream appeal) that views that pro-life movement as too moderate, created an icon linking the acronym AHA in such a way as to resemble newer incarnations of swastikas that are proliferating among white supremacist groups, according to Mason.

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AHA claims that the abortion holocaust exceeds all previous atrocities practiced by the Western World, a statement that signals to anti-Semites an implicit disbelief in the Nazi Holocaust and a trivializing of real historical persecutions. The anti-abortion movement has long framed abortion as a holocausta holocaust that it depicts as numerically more significant than the killing of 6 million Jewish people. Historian Jennifer Holland told Jewish Currents that because Jewish people in the United States are more pro-choice than other religious groups, anti-abortion activists often imply and even outwardly state that Jews are participating in a current genocide and were thus ideologically complicit in the Jewish Holocaust. This frame sometimes goes hand in hand with outright anti-Semitic denial that the Nazi Holocaust even happened.

The framing of abortion-as-holocaust is starkly visible in a law passed by Alabama in May banning abortion in nearly all circumstances and threatening abortion providers with up to 99 years in prison. The law states, More than 50 million babies have been aborted in the United States since the Roe decision in 1973, more than three times the number who were killed in German death camps, Chinese purges, Stalins gulags, Cambodian killing fields, and the Rwandan genocide combined. The framing of abortion as holocaust demeans the significance of the Nazi Holocaust, in turn feeding anti-Semitism already interwoven in the movement.

Florida State Senator Dennis Baxley, discussing the possibility of implementing similar legislation in his state, revealed that nativist fears of replacement went into support for the idea. When you get a birth rate less than 2 percent, that society is disappearing, Baxley said of Western Europe. And its being replaced by folks that come behind them and immigrate, dont wish to assimilate into that society and they do believe in having children.

Anti-choice figures continue to tout demographic concernswhich at their core are a form of white nationalismin order to oppose abortion. In the political sphere, Representative Steve King is the most prominent political figure to emerge as a symbol of both white supremacism and abortion opposition. If we continue to abort our babies and import a replacement for them in the form of young violent men, we are supplanting our culture, our civilization, King stated. King has taken far-right positions on both immigration and abortion, including defending rape and incest as necessary for historical population growth.

These overt expressions of demographic nativism by politicians making decisions about reproductive rights on the state and national level is cause for alarm. With the election of Donald Trump and the rise of the alt-rightan umbrella for white supremacist, male supremacist, and anti-Semitic mobilizationsthe kinder, gentler image the Christian right and the pro-life movement have strategically invested in may be slipping, but also may be less necessary.

Coexisting in abortion opposition is an ideology that honestly seeks to end abortion for people of all races and ethnicities, alongside a white supremacist ideology that only desires to prevent white women from obtaining abortions, but uses universal opposition to abortion as a pragmatic screen for its goals. As Kathleen Belew, author of Bring the War Home: The White Power Movement in Paramilitary America, told The Nation in an interview in September, for white supremacists, opposing abortion, opposing gay rights, opposing feminism, in white power discourse, all of this is tied to reproduction and the birth of white children.

Commenting on the strategic pragmatism of white supremacist movements, Jean Hardisty and Pam Chamberlain wrote in 2000 that public advocacy of abortion for women of color might alienate potential far right supporters who oppose all abortion. White supremacist leaders, like David Duke, have instead focused on other ways to deter birthrates among people of color, such as encouraging long-term contraception or condemning social welfare programs.

The relationship between Christian right anti-abortion, white supremacist, and secular male supremacist ideology is complex. While they often put aside their differences in order to collaborate on shared goals, the agendas are different and inclusive of conflict.

White supremacist responses demonstrated complicated feelings following the passage of the Alabama law, as the Anti-Defamation League (ADL), which tracks hate and bigotry, reported. Some, like the founder of Gab, a popular alternative social media forum frequented by white supremacists and neo-Nazis, heralded the Alabama law. Other white supremacists were unsatisfied that the ban would apply to white women and women of color alike. Longtime white nationalist Tom Metzger eschewed the pragmatic approach in posting on Gab that he had instructed comrades in the Alabama state legislature to introduce a bill that releases all nonwhite women within the borders of Alabama to have free abortions on demand. (Its not clear whether this claim is true or which representatives he meant.)

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Andrew Anglin, founder of the neo-Nazi website The Daily Stormer, writes that while abortion is sick and evil, white supremacists should be focused on the immigrant invasion. Lest readers be disappointed, Anglin reassured them, A great reckoning is comingand it is coming swiftly! The glorious vengeance we take upon these whores will shake the cosmos! Anglin recently referred to himself as the self-appointed spiritual successor to Elliot Rodger, the incel (involuntarily celibate) mass killer who intended retribution on all women for his being sexually rejected. Richard Spencer, the neo-Nazi credited with coining the term alt-right, tweeted that the ban should punish women who seek abortion, but instead demonizes doctors.

Spencers approach, aligning with his other misogynist comments on women, flies in the face of the Christian right frame of protecting women used to advance its agenda in the mainstream. But its the same approach Donald Trump took while on the presidential campaign trail in 2016, when he stated that women should receive some form of punishment if abortion were banned in the United States. After anti-abortion groups made clear that this comment ran afoul of their strategy for banning abortionthough not necessarily their actual preferencesTrump backtracked and instead focused on punishing doctors and stating that the woman is a victim.

On the other hand, MSNBC reported that AHA activists, who refer to themselves as abolitionists, stand for banning all abortion without exceptions, equating hormonal birth control (even the daily pill kind) with abortion, and advocating that women who have abortions be tried as murderers. Under the current Supreme Court, with its Trump-instated anti-choice majority, and the presidents own anti-woman rhetoric, misogyny, and nativism may be becoming more acceptable strategies.

Trump, after all, shows a perfect willingness to cater to the Christian right, but no genuine personal interest in opposing abortion. His brand of secular misogyny, mingling objectification and vilification of women, demonstrates the same ideology as that put forth by secular male supremacist mobilizations such as Mens Rights Activists (MRAs) and The Red Pill, which have little regard for womens rights and well-being. Trumps secretary of education, Betsy DeVos, demonstrated the administrations willingness to give an ear to male supremacist groups at the expense of women when she invited mens rights groups, which spread the myth that women make widespread false accusations of rape despite all data to the contrary, to weigh in on campus sexual assault policy. The result has been the regurgitation of MRA talking points and a proposed rule gutting Obama-era protection for survivors of campus sexual violence.

The anonymous nature of many online forums, like The Red Pill, poses a challenge for determining how much influence members of these communities have. We might be inclined to dismiss Metzgers claim to have comrades in the Alabama state legislature as mere bluster. But before Bonnie Bacarisses investigative reporting in The Daily Beast in 2017 uncovered New Hampshire Republican state Representative Robert Fisher as the founder of The Red Pill, which promotes conspiracist theories about feminist control of society and advocates manipulating women into sexual intercourse, these online misogynist forums were often assumed to be divorced from real-world politics. An online pseudonym that The Daily Beast has linked to Fishers personal e-mail address advocated voting for Trump in 2016 because hed been accused of sexual violence. A spokesperson for a state anti-violence group said that Fisher was part of a very vocal minority in the NH House right now that is very antiwoman and antivictim, and that there had been surprises in recent legislative votes.

These secular misogynist mobilizations address abortion in a variety of ways, though always through the lens of establishing male power and rights, even when endorsing legal abortion. Male supremacist communities seek control over womens bodies, whether it is through denying abortion care or coercing it, or through defending or even perpetrating sexual assault.

While arguments about mens and fathers rights have been used by politicians in suggesting abortion restrictions, such as requiring that a woman receive consent from the man she conceived with in order to obtain an abortion, this is not a key concern for the movements themselves. The misogynist Red Pill forum instead suggested women should have to obtain permission to give birth and that men be able to opt out of child support. The top posts on the Reddit forum r/mensrights related to abortion complain that women hold all the rights when it comes to reproduction, arguing that it is unjust that men have no say in the matter. Not because abortion kills the mans child, as the Christian right would argue, but because men are responsible for 18 years of child support if the pregnancy comes to term. MRAs and MGTOWs (Men Going Their Own Way) refer to this financial obligation as slavery and advocate for paper abortions, where a man can sever financial responsibilities and parental claims to a child.

Paul Elams A Voice for Men, a leading organization in the mens rights movement over the past decade, established in 2010 an editorial policy that would not take an official position on abortion. Elam did criticize womens authority over abortion and painted child support as a means of controlling men, writing, We have an entire fathers rights movement necessitated by the fact that millions of men have had their lives eviscerated, their freedom forfeit, their assets garnisheed, even where paternity fraud has been proven and acknowledged by the courts.

On Return of Kings (ROK), a website listed by the Southern Poverty Law Center as a hate group for pickup artists (PUAs) and founded by Daryush Valizadeh, who goes by Roosh V., the coverage of abortion has shifted from a position accepting of abortionthough not out of support for womens human rightsto an increasingly anti-choice position. In 2013, abortion was discussed as beneficial because it reduces the minority population, demonstrating the racism already inherent in this ideology, and sav[es] a lot of alpha players from having to write a check to a single mom. Other posts promoted access to contraception as a means to prevent abortion, criticizing Christian right opposition to birth control as ineffective to stopping abortion.

Two years later, Valizadeh himself wrote a post on ROK titled Women Must Have Their Behavior and Decisions Controlled by Men, recommending that women receive permission from a guardian to access abortion or birth control. He continues, While my proposals are undoubtedly extreme on the surface and hard to imagine implementing, the alternative of a rapidly progressing cultural decline that we are currently experiencing will end up entailing an even more extreme outcome. (In case youre wondering, Valizadeh has identified other offensive posts as satire, but made no such excuse for this one.) In another 2015 article, The End Goal of Western Progressivism Is Depopulation, he condemns abortion rights, birth control, and female empowerment as causes of declining population that risk Western culture. Valizadeh has admitted to perpetrating acts that meet the legal definition of sexual assault and has endorsed the decriminalization of rape. Though he later claimed that endorsement was a thought experiment, similar excuses have been used by other misogynist leaders such as Paul Elam to provide cover for their most egregious statements.

Further ROK posts on abortion described it as murder and criticized abortion and birth control for destroying traditional families. Matt Forney, a writer whose personal blog appealed to both MRAs and PUAs, referred to women who obtain abortions as monsters, and wrote, If a girl is in favor of abortion, there is evil dwelling in her soul. Forney is a noted white nationalist who also wrote for AltRight.com, and Valizadeh attempted to join him in cozying up with the white supremacist alt-right, sharing the concern for the decline of Western culture. (He turned against this movement after meeting hostility for being a non-white man bragging about sexual intercourse with white women.) The strongest opposition to abortion within the sphere of misogynist groups thus appears to stem from an overlap with the white supremacist movement and concern for the decline of Western culture.

In 2019, Valizadeh announced that he had found God and would no longer promote casual sex. His prior arguments about male control of women and his opposition to abortion and contraception on the basis of concern about population decline, however, fit seamlessly into his new perspective, demonstrating how easy it can be to shift from secular to religious misogyny.

As elements of the male supremacist sphere take on more anti-abortion and white supremacist positions, the confluence of this overt misogyny and racism with the anti-abortion movement may strengthen the support for harsher anti-abortion legislation that eschews the anti-abortion pragmatism of the past and becomes more overt about its criminalization of pregnant people. In 2019, Georgia passed a six-week abortion ban, currently blocked in court, that applies criminal penalties for murder (which includes life imprisonment or the death penalty) for terminating a pregnancy, with no exception for pregnant people self-terminating. Bills like this fulfill Trumps and Abolish Human Abortions claims that the criminalization of abortion should include punishments for women; even though Trump backpedaled because of concerns from mainstream anti-choice groups, his support for this position is already out there, along with his dog whistles to white and male supremacists.

Anti-abortion violence has also been climbing in recent years, as has white supremacist and misogynist violence. Given the history of fatal anti-abortion violence in the 1990s perpetrated by individuals with the connections with white supremacist and anti-Semitic groups, the confluence of these ideologies must be cause for concern beyond the political realm as well.

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The Long History of the Anti-Abortion Movement's Links to White Supremacists - The Nation

Hoth Initiates Preclinical Gene Therapy Program with NC State for the Treatment of Asthma and Allergic Inflammation – P&T Community

NEW YORK, Feb. 4, 2020 /PRNewswire/ --Hoth Therapeutics, Inc. (NASDAQ:HOTH), a biopharmaceutical company focused on unique targeted therapeutics for patients suffering from dermatological indications ranging from atopic dermatitis, psoriasis and acne along with gene therapy treatment for asthmatics, is pleased to announce the initiation of a preclinical study for the treatment of asthma and allergic inflammation in collaboration withNorth Carolina State University(NC State).

The study has begun thedelivery and distribution of nebulized particleswhich willenable the therapeutic oligonucleotide (oligo), short DNA and RNA molecules that have a wide range of applications in gene testing.Hoth has appointed Dr. Glenn Cruse to its Scientific Advisory Board and will oversee the Company's gene therapy programs advancements.

Mr.Robb Knie, Chief Executive Officer of Hoth Therapeutics, Inc. commented,"We are extremely pleased that our gene therapy program with NC State has officially begun and that Dr. Cruse who is overseeing the advancement ofexperimentshas joined our Scientific Advisory Board. Commencement of this initiative is an important step in the development and growth of our company. Dr. Cruse's expertise asa leading mast cell biologist in allergic and inflammatory diseases will be invaluable for the preclinical development of Splice-switching oligonucleotides (SSOs) for asthma."

In November 2019 Hoth entered into a licensing agreement with North Carolina State University (NC State) to study NC State's Exon Skipping Approach for Treating Allergic Diseases. This Exon Skipping Approach was developed by Dr. Glenn Cruse, Principal Investigator and Assistant Professor in the Department of Molecular Biomedical Sciences at the NC State College of Veterinary Medicine. During Dr. Cruse's research, a new approach for the technique of antisense oligonucleotide-mediated exon skipping to specifically target and down-regulate IgE receptor expression in mast cells was identified. These findings set a breakthrough for allergic diseases as they are driven by the activation of mast cells and the release of mediators in response to IgE-directed antigens.

Glenn Cruse completed his Ph.D. at Glenfield Hospital, The University of Leicester, UK in 2009. He then moved to the National Institutes of Health in Bethesda, Maryland in January 2010 to start a visiting postdoctoral fellowship in the Laboratory of Allergic Diseases, NIAID, In January 2015, Dr. Cruse was appointed as a Research Fellow in the same laboratory. Dr. Cruse joined the Department of Molecular Biomedical Sciences at NC State in January 2016 as an Assistant Professor.

Dr. Cruse is a mast cell biologist that has authored and co-authored over 30 publications including articles in top journals such as the New England Journal of Medicine, Proceedings of the National Academy of Sciences USA and Immunity. The Cruse lab is interested in the role that mast cells play in allergic and inflammatory diseases and identifying novel therapeutics that target mast cells. Since mast cells act as sentinel cells that participate in both innate and acquired immunity, particularly at biological barriers, emphasis on diseases in tissues at the interface with the environment such as the lung, skin, gastrointestinal tract and even the neuro-immune axis are the main focus of the lab.

About Hoth Therapeutics, Inc.Hoth Therapeutics, Inc. isa clinical-stage biopharmaceutical company focused on developing new generation therapies for dermatological disorders. HOTH's pipeline has the potential to improve the quality of life for patients suffering from indications including atopic dermatitis, chronic wounds, psoriasis, asthma and acne. To learn more, please visitwww.hoththerapeutics.com.

Forward Looking StatementsThis press release includes "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements in this press release include, but are not limited to, statements that relate to the advancement and development of the BioLexa Platform, the commencement of clinical trials, the availability of data from clinical trials and other information that is not historical information. When used herein, words such as "anticipate", "being", "will", "plan", "may", "continue", and similar expressions are intended to identify forward-looking statements. In addition, any statements or information that refer to expectations, beliefs, plans, projections, objectives, performance or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking. All forward-looking statements are based upon Hoth's current expectations and various assumptions. Hoth believes there is a reasonable basis for its expectations and beliefs, but they are inherently uncertain. Hoth may not realize its expectations, and its beliefs may not prove correct. Actual results could differ materially from those described or implied by such forward-looking statements as a result of various important factors, including, without limitation, market conditions and the factors described under the caption "Risk Factors" in Hoth's Form 10K for the period endingDecember 31, 2018, and Hoth's other filings made with the Securities and Exchange Commission. Consequently, forward-looking statements should be regarded solely as Hoth's current plans, estimates and beliefs. Investors should not place undue reliance on forward-looking statements. Hoth cannot guarantee future results, events, levels of activity, performance or achievements. Hoth does not undertake and specifically declines any obligation to update, republish, or revise any forward-looking statements to reflect new information, future events or circumstances or to reflect the occurrences of unanticipated events, except as may be required by law.

ContactsInvestor Relations Contact:Phone: (646) 756-2997Email:investorrelations@hoththerapeutics.comwww.hoththerapeutics.com

KCSA Strategic CommunicationsValter Pinto (212) 896-1254Hoth@kcsa.com

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SOURCE Hoth Therapeutics, Inc.

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Hoth Initiates Preclinical Gene Therapy Program with NC State for the Treatment of Asthma and Allergic Inflammation - P&T Community

AskBio Announces First Patient Dosed in Phase 1 Trial Using AAV Gene Therapy for Congestive Heart Failure – BioSpace

RESEARCH TRIANGLE PARK, N.C. , Feb. 04, 2020 (GLOBE NEWSWIRE) -- Asklepios BioPharmaceutical (AskBio), a clinical-stage adeno-associated virus (AAV) gene therapy company, and its NanoCor Therapeutics subsidiary today announced that the first patient has been dosed in a Phase 1 clinical trial of NAN-101. NAN-101 is a gene therapy that aims to activate protein phosphatase inhibitor 1 (I-1c) to inhibit the activity of protein phosphatase 1 (PP1), a substance that plays an important role in the development of heart failure.

Congestive heart failure (CHF) is a condition in which the heart is unable to supply sufficient blood and oxygen to the body and can result from conditions that weaken the heart muscle, cause stiffening of the heart muscles, or increase oxygen demand by the body tissues beyond the hearts capability.

"Dosing the first patient using gene therapy to target I-1c to improve heart function is a tremendous milestone not only for the AskBio and NanoCor teams but, more importantly, for patients whose quality of life is negatively affected by CHF, said Jude Samulski, PhD, Chief Scientific Officer and co-founder of AskBio. We initially developed this gene therapy as treatment for late-stage Duchenne muscular dystrophy patients who typically die from cardiomyopathy. Following preclinical studies, we observed that heart function improved, which led us to investigate treatment for all types of heart failure.

Were excited to be involved in this novel approach for patients with Class III heart failure, said Timothy Henry, MD, FACC, MSCAI, Lindner Family Distinguished Chair in Clinical Research and Medical Director of The Carl and Edyth Lindner Center for Research at The Christ Hospital in Cincinnati, Ohio, and principal investigator for the study. These patients currently have no other options besides transplant and left ventricular assist devices (LVAD). Today, we started to explore the potential of gene therapy to change their outcomes.

Heart disease is the leading cause of death worldwide, with CHF affecting an estimated 1% of the Western world, including over six million Americans. There is no cure, and medications and surgical treatments only seek to relieve symptoms and slow further damage.

Research by many investigators around the world has been trying to understand what exactly goes wrong in the heart and weakens its pumping activity until it finally fails, said Evangelia (Litsa) Kranias, PhD, FAHA, Hanna Professor, Distinguished University Research Professor and Director of Cardiovascular Biology at the University of Cincinnati College of Medicine. The aim has been to identify potential therapeutic targets to restore function or prevent further deterioration of the failing heart. Along these lines, research on the role of I-1c started over two decades ago, and it moved from the lab bench to small and large animal models of heart failure. The therapeutic benefits at all levels were impressive. It is thrilling to see I-1c moving into clinical trials with the hope that it also improves heart function in patients with CHF.

About the NAN-101 Clinical Trial NAN-CS101 is a Phase 1 open-label, dose-escalation trial of NAN-101 in subjects with NYHA Class III heart failure. NAN-101 is administered directly to the heart via an intracoronary infusion by cardiac catheterization in a process similar to coronary angioplasty, commonly used to deliver treatments such as stem cells to patients with heart disease. The primary objective of the study is to assess the safety of NAN-101 for the treatment of NYHA Class III heart failure, as well as assess the impact of this treatment on patient health as measured by changes in exercise capacity, heart function and other factors including quality of life.

AskBio is actively enrolling patients with NYHA Class III heart failure to assess three doses of NAN-101. Please refer to clinicaltrials.gov for additional clinical trial information.

Would you like to receive our AskFirst patient engagement program newsletter? Sign up at https://www.askbio.com/patient-advocacy.

About The Christ Hospital Health Network The Christ Hospital Health Network is an acute care hospital located in Mt. Auburn with six ambulatory centers and dozens of offices conveniently located throughout the region. More than 1,200 talented physicians and 6,100 dedicated employees support the Network. Its mission is to improve the health of the community and to create patient value by providing exceptional outcomes, the finest experiences, all in an affordable way. The Network has been recognized by Forbes Magazine as the 24th best large employer in the nation in the magazines Americas 500 Best Large Employers listing and by National Consumer Research as the regions Most Preferred Hospital for more than 22 consecutive years. The Network is dedicated to transforming care by delivering integrated, personalized healthcare through its comprehensive, multi-specialty physician network. The Christ Hospital is among only eight percent of hospitals in the nation to be awarded Magnet recognition for nursing excellence and among the top five percent of hospitals in the country for patient satisfaction. For more than 125 years, The Christ Hospital has provided compassionate care to those it serves.

About AskBioFounded in 2001, Asklepios BioPharmaceutical, Inc. (AskBio) is a privately held, clinical-stage gene therapy company dedicated to improving the lives of children and adults with genetic disorders. AskBios gene therapy platform includes an industry-leading proprietary cell line manufacturing process called Pro10 and an extensive AAV capsid and promoter library. Based in Research Triangle Park, North Carolina, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. An early innovator in the space, the company holds more than 500 patents in areas such as AAV production and chimeric and self-complementary capsids. AskBio maintains a portfolio of clinical programs across a range of neurodegenerative and neuromuscular indications with a current clinical pipeline that includes therapeutics for Pompe disease, limb-girdle muscular dystrophy type 2i/R9 and congestive heart failure, as well as out-licensed clinical indications for hemophilia (Chatham Therapeutics acquired by Takeda) and Duchenne muscular dystrophy (Bamboo Therapeutics acquired by Pfizer). For more information, visit https://www.askbio.com or follow us on LinkedIn.

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AskBio Announces First Patient Dosed in Phase 1 Trial Using AAV Gene Therapy for Congestive Heart Failure - BioSpace

Researches at UCSD Health Sciences identify gene with functional role in aging of eye – A lengthy-named gene called Elongation of Very Long Chain…

Researches at UCSD Health Sciences identify gene with functional role in aging of eye

San Diego Community News Group

A lengthy-named gene called Elongation of Very Long Chain Fatty Acids Protein 2 or ELOVL2 is an established biomarker of age. In a new paper, published online Jan. 14, 2020 in the journal Aging Cell, researchers at the University of California San Diego School of Medicine say the gene appears to play a key role in age-associated functional and anatomical agingin vivoin mouse retinas, a finding that has direct relevance to age-related eye diseases.

Specifically, the research team, led by senior author Dorota Skowronska-Krawczyk, Ph.D., assistant professor in the Viterbi Family Department of Ophthalmology at UC San Diego Shiley Eye Institute, found that an age-related decrease in ELOVL2 gene expression was associated with increased DNA methylation of its promoter. Methylation is a simple biochemical process in which groups of carbon and hydrogen atoms are transferred from one substance to another. In the case of DNA, methylation of regulatory regions negatively impacts the expression of the gene.

When researchers reversed hypermethylationin vivo, they boosted EVOVL2 expression and rescued age-related decline in visual function in mice. These findings indicate that ELOVL2 actively regulates aging in mouse retina, provides a molecular link between polyunsaturated fatty acids elongation and visual functions, and suggests novel therapeutic strategies for treatment of age-related eye diseases, wrote the authors.

ELOVL2 is involved in production of long-chain omega-3 and omega-6 polyunsaturated fatty acids, which are used in several crucial biological functions, such as energy production, inflammation response and maintenance of cell membrane integrity. The gene is found in humans as well as mice.

In particular, ELOVL2 regulates levels of docosahexaenoic acid or DHA, a polyunsaturated omega-3 fatty acid abundantly found in the brain and retina. DHA is associated with a number of beneficial effects. Notably, its presence in photoreceptors in eyes promotes healthy retinal function, protects against damage from bright light or oxidative stress and has been linked to improving a variety of vision conditions, from age-related macular (AMD) degeneration to diabetic eye disease and dry eyes.

Skowronska-Krawczyk said the work demonstrated for the first time that a methylation clock gene had a functional role in the aging of an organ. In this case, the eye. DNA methylation is used throughout the human body, essentially turning biological switches on and off to maximize efficient operation. It has key regulatory roles in the bodys cardiovascular, neurological, reproductive and detoxification systems.

In recent years, there has been much work and progress in identifying possible biomarkers that predict the biological age (not chronological) of individuals. Such biomarkers would be useful in identifying risk and status of age-related diseases. ELOVL2 is among the genes attracting greatest interest.

I have been asked whether I think ELOVL2 istheaging gene, said Skowronska-Krawczyk. After thinking about it, it is not unreasonable to think that lower ELOVL2 expression might be at the basis for many age-related conditions. Future work in our lab will address that question.

For the full study, visithttps://onlinelibrary.wiley.com/doi/full/10.1111/acel.13100

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Researches at UCSD Health Sciences identify gene with functional role in aging of eye - A lengthy-named gene called Elongation of Very Long Chain...

Experts dispute 9 of 17 genes once linked to long QT syndrome – Cardiovascular Business

ClinGen is funded by the National Human Genome Research Institute (NHGRI), which is itself part of the National Institutes of Health. Erin Ramos, PhD, a project scientist for ClinGen and program director for the division of genomic medicine at NHGRI, said in a release that NHGRI developed ClinGen as a way to standardize guidelines for genetic testing. A panel of experts, including researchers, clinicians and genetic counselors comb through scientific evidence from research papers to identify gene-disease relationships as either definitive, strong, moderate, limited, disputed or refuted.

The experts reported that three genesKCNQ1, KCNH2 and SCN5Awere indeed backed by enough evidence to be categorized as definitive genetic triggers for long QT syndrome. They classified four other genes as either strong or definitive for causing atypical forms of long QT syndrome, but the panel didnt find enough evidence to support the remaining 10 genes.

Those 10 genes were all placed in either the limited or disputed category for their link to long QT syndrome, and for that reason the authors said they dont recommend using them as markers in routine clinical tests.

Our study highlights the need to take a step back and to critically evaluate the level of evidence for all reported gene-disease associations, especially when applying genetic testing for diagnostic purposes in our patients, Gollob said in a statement. Testing genes with insufficient evidence to support disease causation only creates a risk of inappropriately interpreting the genetic information and leading to patient harm.

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Experts dispute 9 of 17 genes once linked to long QT syndrome - Cardiovascular Business