David Sinclair supplements and protocol explained NMN …

If you watched any of David Sinclair videos you probably noticed that he looks younger than he actually is. When I saw the video it made me think that this guy must be doing something that works for him. I did some research, and that brought me to his Joe Rogan podcast, where he explains exactly what he is doing to stay young.

I would highly suggest that you go watch the video as he gives out a massive amount of valuable information.

I will first give you an overview of all the things he does and then later try to explain how everything comes together

List of things David Sincalir consumes or does

Sirtuins are genes which protect all organisms from deterioration and disease. NMN and Resveratrol are molecules which essentially mimic the effects of the sirtuin genes.

NMN also boosts NAD levels (which sirtuins need to function)

Nicotinamide mononucleotide is a nucleotide derived from ribose and nicotinamide. Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide.

Formula: C11H15N2O8PMolar mass: 334.2192 g/mol

Resveratrol is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi. Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts.

Molar mass: 228.25 g/molFormula: C14H12O3Solubility in water: 0.03 g/LMelting point: 261 to 263 C (502 to 505 F; 534 to 536 K)Appearance: white powder with; slight yellow castSolubility in DMSO: 16 g/L

Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. It is not associated with weight gain. It is taken by mouth.

Molar mass: 129.1636 g/molFormula: C4H11N5Excretion: Urine (90%)Trade name: Glucophage, otherBioavailability: 5060%Elimination half-life: 48.7 hours

There are 3 pathways related to aging:

Intermittent fasting is an umbrella term for various eating diet plans that cycle between a period of fasting and non-fasting over a defined period. Intermittent fasting is under preliminary research to assess if it can produce weight loss comparable to long-term calorie restriction.

The main idea is that you ideally skip a meal or two, therefore putting your body in a state of starvation which triggers different processes in the body, which are proved to have a broad variety of benefits, some of them include anti ageing benefits.

David recommends performing exercise regularly. He recommends running and doing resistance training.

David especially recommends exposing your body to temperature extremes which force your body to kick start protective mechanisms. He recommends doing a hot sauna immediately followed by cold water submersion.

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David Sinclair supplements and protocol explained NMN ...

Lifespan: Why We Age_and Why We Don’t Have To: David A …

Lifespanis entertaining and fast-paceda whirlwind tour of the recent past and a near future that will see 90 become the new 70. In a succession of colorfully titled chapters (The Demented Pianist, A Better Pill to Swallow), Sinclair and LaPlante weave a masterful narrative of how we arrived at this crucial inflection point., Nature Journal

Sinclairs work on slowing the aging process, and even reversing some aspects of it, could lead to the most significant set of medical breakthroughs since the discovery of antibiotics nearly a century ago., Sydney Morning Herald

"In this insightful and provocative book that asks questions about how we age, and whether humans can overcome decay and degeneration, Sinclair grapples with some of the most fundamental questions around the science of aging. The result is an elegant and exciting book that deserves to be read broadly and deeply." -- Siddhartha Mukherjee, Pulitzer Prizewinning and #1 New York Times bestselling author

There are few books that have ever made me think about science in a fundamentally new way. David Sinclairs book did that for me on aging. This is a book that anyone who ages must read. -- Leroy Hood, PhD, professor at the California Institute of Technology, inventor, entrepreneur, member of all three US National Academies, and co-author of Code of Codes

If you ever wondered how we age, if we can slow or even reverse aging, and if we can live a healthy 100 plus years, then David Sinclairs new bookLifespan, which reads like a detective novel, will guide you through the science and the practical strategies to make your health span equal your lifespan, and make your lifespan long and vibrant. -- Mark Hyman, MD, director of the Cleveland Clinic Center for Functional Medicine and #1 New York Times bestselling author

This is the most visionary book about aging I have ever read.Seize the dayand seize this book! -- Dean Ornish, MD, founder and president of the Preventative Medicine Research Institute and New York Times bestselling author of UnDo It!

In Lifespan, David Sinclair eloquently tells us the secret everyone wants to know: how to live longer and age slower. Boldly weaving cutting-edge science with fascinating bits of history, sociology, and morality, Sinclair convinces us that it is not only possible to live beyond one hundred years, it is inevitable that we will be able to one day do so. If you are someone who wants to know how to beat aging, Lifespan is a must-read. -- William W. Li, MD, New York Times bestselling author of Eat to Beat Disease

For years, the aging field has been about vitamins, juicebars, and snake oil. Now, in a seminal book, Harvard Professor David Sinclair has changed the landscape: he has combined precise science, practical translation, and autobiography to produce a rare book that is insightful, inspiring, and informative. He has translated a wealth of molecular detail into a program that we can all use to live longer and healthier. This is part of the ongoing revolution in aging and chronic disease, and there is no one who is better suited to write such an authoritative book than David Sinclair. For anyone interested in understanding the aging process, living longer, and avoiding the diseases of aging, this is the book to read. -- Dale Bredesen, MD, New York Times bestselling author of The End of Alzheimer's

A visionary book from one of the most masterful longevity scientists of our time. Lifespan empowers us to change our health today while revealing a potential future when we live younger for longer. -- Sara Gottfried, MD, New York Times bestselling author of The Hormone Cure

Prepare to have your mind blown. You are holding in your hands the precious results of decades of work, as shared by Dr. David Sinclair, the rock star of aging and human longevity. -- Dave Asprey, founder and CEO of Bulletproof and New York Times bestselling author of The Bulletproof Diet

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Lifespan: Why We Age_and Why We Don't Have To: David A ...

#70 – David Sinclair, Ph.D.: How cellular reprogramming could …

In this episode, David Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, returns to the podcast to discuss the content of his new book, Lifespan: Why We Age and Why We Dont Have To. This conversation focuses on the biological mechanisms involved in what David terms the Information Theory of Aging which provides insights into the clock that determines our aging and to what degree it can be manipulated. Our discussion on aging of course leads us into interconnected topics of epigenetics, sirtuins, cellular senescence, as well as what compounds David is personally taking for his own longevity. Additionally, we discuss the most up to date information related to NAD and longevity by looking at the potential benefits (if any) of supplemental agents (NAD precursors, NR, NMR, etc.) that pose a promise of increasing NAD.

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The SIR gene silent information regulator is a gene that controls other genes

The SIR enzyme is the master regulator of this cellular survival circuit

Figure 1. When SIR enzyme proteins detect stress in the cell (e.g. DNA breakage) the protein leaves the silent region to go and repair the DNA. When the problem is fixed, it returns to its original post, silencing genes. Image credit: (Alves-Fernandes and Jasiulionis, 2019)

Overtime, in the back-and-forth of repair SIR genes lose track of which genes should be silenced or not

We have some early evidence from mice that we can actually find that hard disk drive and reinstall the software so that its pristine again and we find that we can actually improve the health quite dramatically in parts of a mouses body. David Sinclair, Ph.D

What does Claude Shannons Information Theory of Communication have to do with aging?

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David A. Sinclair, Ph.D. is a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging.

He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co-discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where his laboratorys research has focused primarily on understanding the role of sirtuins in disease and aging, with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. He has also contributed to the understanding of how sirtuins are modulated by endogenous molecules and pharmacological agents such as resveratrol.

Dr. Sinclair is the co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. His work is featured in five books, two documentary movies, 60 Minutes, Morgan Freemans Through the Wormhole and other media.

He is an inventor on 35 patents and has received more than 25 awards and honors including the CSL Prize, The Australian Commonwealth Prize, Thompson Prize, Helen Hay Whitney Postdoctoral Award, Charles Hood Fellowship, Leukemia Society Fellowship, Ludwig Scholarship, Harvard-Armenise Fellowship, American Association for Aging Research Fellowship, Nathan Shock Award from the National Institutes of Health, Ellison Medical Foundation Junior and Senior Scholar Awards, Merck Prize, Genzyme Outstanding Achievement in Biomedical Science Award, Bio-Innovator Award, David Murdock-Dole Lectureship, Fisher Honorary Lectureship, Les Lazarus Lectureship, Australian Medical Research Medal, The Frontiers in Aging and Regeneration Award, Top 100 Australian Innovators, and TIME magazines list of the 100 most influential people in the world. [medapps.med.harvard.edu] His new book, Lifespan, explains why we age and why we dont have to.

David on LinkedIn: David A. Sinclair, Ph.D. A.O.

David on Twitter: @davidasinclair

David on Instagram: davidsinclairphdDavids book website: lifespanbook.com

BOSTON, MA - MAY 16: David A. Sinclair, Professor of Genetics and Director of the Paul F. Glenn Center for the Biology of Aging, poses for a portrait in the lab at Harvard Medical School in Boston on May 16, 2018. (Photo by Craig F. Walker/The Boston Globe via Getty Images)

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#70 - David Sinclair, Ph.D.: How cellular reprogramming could ...

NMN and NAD Reverse Aging of Blood Vessels in New Study

Reading Time: 5 minutes. >>

Harvard professor Dr. David Sinclair reports that the NAD boosting NMN compound reverses aging in blood vessels and restores muscle strength in a new study published March 22nd. [This article firstappeared onLongevityFacts. Author:Brady Hartman.]

Using the NAD boosting molecule NMN, Dr. David Sinclairs team reversed blood vessel and muscle aging in mice, while boosting their exercise endurance. As Dr. Sinclair says

Weve discovered a way to reverse vascular aging by boosting the presence of naturally occurring molecules in the body that augment the physiological response to exercise addingThe approach stimulates blood vessel growth and boosts stamina and endurance in mice and sets the stage for therapies in humans to address the spectrum of diseases that arise from vascular aging.

The team says the achievement paves the way for similar therapies for humans and published the results of their study on March 22 in the journal Cell.

David A. Sinclair, Ph.D. is best known for his research on the NAD molecule and its role in increasing health in aging bodies. Dr. Sinclair is a professor in the Department of Genetics and a Co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School (HMS) as well as a Professor at the University of New South Wales, Sydney.

In a video accompanying the new study, published by Harvard News, Dr. David Sinclair describes the compound NMN boosts levels of NAD in the bodies of aging mice, and how that restores muscle function.

Vascular aging leads to a deterioration in many organs and tissues throughout the human body, as Dr. David Sinclair says:

As we age, the tiniest blood vessels in our bodies wither and die, reducing the blood flow to organs and tissues. Vascular aging causes many diseases cardiovascular, neurological, muscle wasting, frailty, and even aging. Here at Harvard Medical School, weve reversed the process in mice, setting the stage for radical new therapies to help people. The new study has unraveled the cascade of interactions between blood vessels and muscles.

Dr. David Sinclair also describes the how aging of the cells lining our blood vessels leads to a decline in our vascular systems and muscles, saying:

Endothelial cells, which line the walls of blood vessels, are essential for the health and growth of the vessels. And as endothelial cells age, blood vessels begin to atrophy and die. Blood flow to many parts of the body diminishes, organs and tissues begin to function less well. Blood vessel demise hits muscles especially hard because muscles rely on a robust blood supply for their function. This process can be slowed down with regular exercise, but only up to a point. Over time, even exercise fails to stave off blood vessel demise and muscle loss.

The newstudy suggests that this loss of blood flow is a key driver behind age-related muscle loss and frailty. Even if we exercise, our muscles shrink as we get older, as Dr. David Sinclair says

The new findings have cracked the mystery behind this process. As our blood vessels age, they become deaf to the signals from exercise muscles. This actually leads to the muscles shrinking as we get older, and therefore were less able to exercise and grow new blood vessels. A vicious cycle indeed.

The declining levels of NAD in our bodies cause this aging process. However, using NMN to boost levels of NAD stimulates a sirtuin protein called SIRT1, asDr. David Sinclair describes

The two key players in the crosstalk between blood vessels and muscles are a molecule called NAD and a protein called SIRT1. NAD boosts SIRT 1, which in turn enables the conversation between muscles and blood vessels. But both NAD and SIRT1 decline as we age. They can no longer perform their role as the interface between muscles and blood vessels.

Finally, the researcher describes how giving the compound NMN to mice boosted their levels of NAD, producing remarkable results, as Dr. David Sinclair says,

In our new study, we gave mice NMN, a chemical compound commonly found in the body and previously shown to boost NAD levels, which in turn boosts SIRT1. These mice had better endothelial function, blood vessel growth and improved blood supply to their muscles.

The most striking effect of was a significant boost in the mices ability to exercise. The aging mice treated with NMN gained between 56 and 80 percent greater exercise capacity, compared with untreated ones by being able to run much farther on a treadmill. According to Dr. Sinclair, the mice treated with NMN had improved exercise capacity due to improvements in vascular function, saying

And what was most striking? These animals capacity for exercise improved dramatically. In fact, the old mice treated with NMN had up to 80 percent greater exercise capacity, compared with the untreated old mice.

Sinclair believes that the results achieved in mice can eventually be translated to humans, helping to counter age-related diseases with a vascular component, such as frailty, heart attack, stroke or even forms of dementia such as Alzheimers disease. As Dr. David Sinclair says in his parting words,

These results, I believe, can help millions of people who have lost their mobility, or simply can no longer exercise, either through frailty, disability or old age. This sets the stage for new medicines that will be able to restore blood flow in organs that have lost it, either through a heart attack, a stroke or even in patients with dementia.

Related: Trial suggests nicotinamide riboside (NR) may help vascular health.

Photo Credit: All images courtesy of Dr. David Sinclair / Harvard Medical School.

Diagnosis, Treatment, and Advice:This article is intended for informational and educational purposes only and is not a substitute for qualified, professional medical advice. The opinions and information stated in this article should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Consult a qualified and licensed physician for the diagnosis and treatment of any and all medical conditions. Experimental treatments to boost NAD such as NMN carry a much higher risk than FDA-approved ones. Dial 9-1-1, or an equivalent emergency hotline number, for all medical emergencies. As well, consult a licensed, qualified physician before changing your diet, supplement or exercise programs.Photos,Endorsements, & External Links:This article is not intended to endorse organizations, companies, or their products. Links to external websites, mention or depiction of company names or brands, are intended for illustration only and do not constitute endorsements.

Tags: Dr. David Sinclair, NAD, NMN

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NMN and NAD Reverse Aging of Blood Vessels in New Study

David Sinclair on Joe Rogan Podcast – chatting about NMN and …

Joe Rogan interviewed Dr Sinclair for 2 1/2 hours last week, and aired on his popular podcast on Jan 29th.

We were looking forward to this for weeks, as Dr Sinclair is always a great interview and probably the most knowledgable person on the planet regarding the current state of research on NAD+.

In case youre not that familiar, research with NAD+, and compounds to boost it like NMN and NR, are showing incredible results for health and longevity.

So if you want to be amazed and excited about the potential of stopping, or even reversing damage from aging (who doesnt?) check out Joe and David having a great chat

Heres a few notes taken by our friend David, from the NAD Boosters Facebook group

33:45 The epigenome and the cause of aging. Your DNA contains all your genes and the epigenome controls which genes are actually expressed, so that a liver cell can be a liver cell and a brain cell a brain cell. Over time, cells lose the ability to read the DNA, similar to a laser trying to read a scratched CD. Cells then become dysfunctional. In older people a liver cell might show up in the brain and a brain cell in the kidney, all because its becoming harder to read the CD and the wrong genes are getting expressed. So how do you polish the CD to get the information that was easy to read in your teens and twenties restored again, resetting your age? They havent actually polished the entire CD yet but they are currently working on ways to do this in order to reset the entire epigenome back to a younger age. See further explanation of this further down at 1:51:45. Theyve already figured out how to polish parts of the epigenome and repair tissue.

43 Advances in ability to reprogram the epigenome. Clinical trials in early 2020 will focus on restoring eyesight, repairing spinal injuries and more.

1:45:40 Sinclair has a company called Metro Biotech that makes super NAD Boosters. They are testing this developmental drug (called MIB-626) along with NMN.

1:51:45 New bioage test called the DNA clock. The epigenome changes over time due to methyls that bind to the DNA. The older you get the more methyls you accumulate (sunlight and x-rays are 2 examples of many that cause methyls to bind). Sinclair compares this to scratches on a CD that make the DNA harder to read. These build up over time, causing aging. They can now read the methyls (scratches) on your DNA and give you a precise bioage. Sinclair said they believe that they can now reverse these scratches on the CD. They are testing it now to reprogram the epigenome and re-grow optic nerves as well as reverse glocoma. Published results will be soon. As mentioned clinical trials in early 2020.

1:53:30 Gives a sneak preview they are about to announce a new academy for aging research made up of the top 20 longevity scientists in the world to produce white papers and opinions, sort of like a Manhattan Project for longevity research.

The official notes from the Joe Rogan Podcast:

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David Sinclair on Joe Rogan Podcast - chatting about NMN and ...

5 Unknown Health Benefits of Drinking Wine – Nature World News

Nov 23, 2019 09:55 AM EST

Aside from the family and the bedroom that we look forward to when going home, sitting on a couch while drinking something gives you a sense of comfort and peace of mind. A glass of wine is one good example.

Wines, in general, are alcoholic beverages. However, unlike other liquors, they are made from natural ingredients. The main ingredient of a wine is various grape varietals planted in a specific estate. It undergoes strict cultivation and fermentation process to produce authentic taste.

Aside from the sense of comfort and relief, people are also looking forward to the health benefits that wines provide. Although wines contain alcohol, most of its ingredients have potent natural antioxidants which are beneficial to our health.

Resveratrol is one of the substances found in wine that renders many health advantages which can be found at the grapes' skin and seeds. Some common health benefits of resveratrol are reducing bad cholesterol, regulating blood pressure, protecting the brain cells from damage, just to name a few.

While there are many proven results that are already familiar to you, there are still other advantages that you might not have known. Thus, here are some other health benefits of drinking wine that may surprise you.

It may surprise you, but wines such asCabernet Sauvignon Winescan actually help control the growth of acne. Bear in mind that acne breakout is a serious problem due to hormones or poor hygiene practices. Apart from taking prescribed medications, drinking wine may also work wonders for your skin.

In some cases, wine comes a skincare agent. After sipping a glass of your favorite wine label, you can pour a few drops in a cotton ball and gently rub it all over your face. It tightens the skin of your face and controls the production of oil. In that sense, the growth of acne gets prevented, giving you a younger and fairer-looking skin.

Improving one's memory is another health benefit that wine brings. As we age and get older, we tend to lose our memory and cognitive response gets lower. It means that our ability to remember things for a long period is affected. It is why drinking a glass of wine every day can boost our memory as we get older.

According to the study, resveratrol in wine is the main antioxidantthat helps protect the brain cells from damage. It helps in lowering the sugar content in our blood that can sometimes affect the ability of our brain to grasp quick ideas. Besides, wine also helps in strengthening the brain cells to avoid any severe problems it may encounter.

You may not have known this before, but drinking a modest wine like a glass or two every day helps you get stronger and white teeth.

The antioxidants found in wine are proven to fight the bacteria that can cause oral plaque, making sure that you do not develop cavities. That's why if you want a bright smile, it's time to drink wine regularly, in moderation.

Generally, it is rare for someone to maintain a good mood all the time. We all start our day in different ways, and some things just go beyond our control. However, there's always a thin line between being happy and choosing to stay positive. It may be hard to choose the latter, but wines can undoubtedly help you with that.

Drinking a glass of red wine before going to bed helps you get better sleep. When you have enough hours and better rest, your mood the next day will surely come as bright as the sunrise. Besides, sipping a glass of wine can also relieve the pressure and anxiety you feel.

Most of us wanted to get fit and achieve the best body aesthetics to flaunt everywhere. We can accomplish this by going to the gym regularly and take strenuous workouts. We all do our best to sweat a lot, so we develop that body muscles and thin waistline.

On the other hand, drinking wine helps you save time going to the gym. A glass of red wine can burn calories in your body the same amount that shed off while sweating out in a fitness gym. Aside from that, you also maintain the health of your heart, bone, and mind in the most excellent state.

There are lots of health advantages that wines can provide. Some are widely known before, which people keep on practicing. Therefore, the surprising additional benefits mentioned above will surely entice and convince you to take a glass of wine today.

2018 NatureWorldNews.com All rights reserved. Do not reproduce without permission.

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Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disea | CIA – Dove Medical Press

Blanca Olivia Murillo Ortiz,1 Alma Rosa Fuentes Preciado,2 Joel Ramrez Emiliano,2 Sandra Martnez Garza,1 Edna Ramos Rodrguez,3 Luz Anglica de Alba Macas2

1Clinical Epidemiology Research Unit, UMAE No. 1 Bajio, Mexican Institute Social Security, Len, Guanajuato, Mexico; 2Department of Medical Sciences, University of Guanajuato, Len, Guanajuato, Mexico; 3Regional General Hospital No. 58, Mexican Institute Social Security, Len, Guanajuato, Mexico

Correspondence: Blanca Olivia Murillo OrtizUnidad de Investigacin en Epidemiologa Clnica, Unidad Mdica de Alta Especialidad No. 1 Bajo, Instituto Mexicano del Seguro Social, Boulevard Lpez Mateos e Insurgentes s/n, Colonia Los Parasos, Len, Guanajuato, MxicoTel/Fax +52 4777183039Email bomo907@hotmail.com

Introduction: Malnutrition is common in haemodialysis patients and closely related to morbidity and mortality. We evaluated the effect of twelve weeks of supplementation with resveratrol and curcumin on recovery of bone and muscle mass and protein oxidation, lipid peroxidation on patients with chronic kidney disease and iron overload undergoing hemodialysis, we performed a randomized, double-blind, placebo-controlled trial.Methods: We included a total of 40 patients, were randomly assigned to two groups, 20 to the group with antioxidant supplementation (Resveratrol + Curcumin) (Group A), treated with a daily oral dose of 500 mg of Resveratrol and 500 mg of Curcumin, and 20 to the control group treated with placebo (Group B).Results: Significant differences were found in the body composition of the patients between both groups. There was a significant difference in Body Mass Index (BMI) values (p = 0.002), fat percentage (p = 0.007), muscle mass (p = 0.01) bone mass (p = 0.01), as well as in the score of the subjective global evaluation (p = 0.03). Also differences were found between the basal and final serum levels of Triglycerides (TG) (p = 0.01), VLDL (p = 0.003). A significant decrease in the levels of serum ferritin (2003.69 518.73 vs 1795.65 519.00 ng/mL; p = 0.04). Nor were significant differences observed between the baseline and the final Thiobarbituric Acid Reactive Substances (TBARS) values (70.45 69.21 vs 50.19 32.62, p = 0.24). The same results was obtained for carbonyl values (2.67 0.75 vs 2.50 0.85; p = 0.50).Discussion: The present study is the first assay on patients with chronic kidney disease and iron overload that demonstrates the beneficial effects of combined supplementation with Curcumin and Resveratrol on muscle and bone mass. There was a significant decrease in circulating levels of ferritin, to finding that remarkably novel.

Keywords: curcumin, resveratrol, chronic kidney disease, recovery of bone and muscle mass

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disea | CIA - Dove Medical Press

Resveratrol Supplements Expected to Witness a Fast-paced Growth Over the Forecast Period 2019 2028 – Tech Admirers

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Resveratrol Supplements Expected to Witness a Fast-paced Growth Over the Forecast Period 2019 2028 - Tech Admirers

Cardioprotective properties found in pterostilbene: Study – NutraIngredients-usa.com

Pterostilbene polyphenol that is often compared to its cousin resveratrol, although it has been found to be much more metabolically stable and bioavailable due to its molecular structure. Pterostilbene can be founding a number of plants.

Herbal extract manufacturer and supplier Sabinsa offers pterostilbene, the active compound in Sabinsas Silbinol range of products. It is extracted from the heartwood of Pterocarpus marsupium, also known as the Indian Kino Tree. Pterocarpus is a genus of pantropical trees in the Fabaceae family and originates from dry, hilly areas of India, Sri Lanka and Nepal.

The ingredient was the subject of a new study published by Sabinsa researchers and academic scientists from Taiwan and China in the journal Molecular Nutrition and Food Research.

The joint study suggests cardioprotective properties in pterostilbene after the researchers found that it reduces Trimethylamine-N-oxide (TMAO) formation and decreases vascular inflammation in mice. TMAO is a risk factor for atherosclerosis, heart disease as well as for colorectal cancer in postmenopausal women. With that mind, Sabinsa said, Consequently, ingredients that lower TMAO are welcome additions to the repertoire of supplements.

The researchers found that pterostilbene was shown to influence gut microbiota and lower inflammatory genes in the mice.

The study concluded, These data suggest that amelioration of carnitineinduced vascular inflammation after consumption of pterostilbene is partially mediated via modulation of gut microbiota composition and hepatic enzyme FMO3 gene expression.

In other words,While weve known that Silbinols pterostilbene is a powerful antioxidant, this research has significantly advanced our understanding of its mechanisms of action and benefits for heart health, said Dr. Muhammed Majeed, Sabinsas founder.

When asked about studies beyond mice, Majeed told NutraIngredients-USA that Sabinsa doesn't have any human studies in the pipeline, "but it's an intriguingarea of research."

Source:

Molecular Nutrition and Food Research

Volume 63, Issue 20 Oct 2019 1900514 doi.org/10.1002/mnfr.201900514

Prevention of Vascular Inflammation by Pterostilbene via TrimethylamineNOxide Reduction and Mechanism of Microbiota Regulation

Author: Y. Koh, et al.

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Cardioprotective properties found in pterostilbene: Study - NutraIngredients-usa.com

What the industry needs to know about polypharmacology – NutraIngredients-usa.com

One advantageous strategy the nutraceutical industry uses in botanical extract development involves multiple compounds from plants that hit a variety of biological pathways.

When you say polypharmacology people dont know what youre talking about, said Dan Gubler, PhD.

The term doesnt exactly roll off the tongue. According Gubler, a natural products chemist, there are two different models to support health and wellness: Polypharmacology and mono pharmacology.

Mono pharmacology is a practice employed by pharmaceutical companies. Its one molecule, binding to one target, that causes a biological response. The method the pharmaceutical uses is for treatment and sick care. This molecule is a synthesized molecule. One potential issue is that these synthesized compounds are unnatural to the body and not recognized by the liver, Gubler said.

Polypharmacology on the other hand, is used by science-based nutraceutical companies. This method uses multiple natural compounds from plants, which target several receptors in the body. Gubler told NutraIngredients-USA that there is a lot of potential synergy with polypharmacology. When you intelligently include multiple compounds from plants, you can harness greater power than you can in some cases with mono pharmacology.

Now I have nothing against big pharma, drugs have saved millions of lives. But theres this alternate approach, this everyday preventative well care approach, and thats what we offer in the nutraceutical industry.

Theres a lot of new science and a lot of new formulations that could be developed with clinical studies, with good science, they could help with preventative, daily well care, instead of sick care. Polypharmacology is used for preventative well care. When you think about compounds like curcuminoids from curcumin, or resveratrol from red wine, flavonals from cacao, these compounds have the ability to support everyday health and wellness, Gubler said.

Other examples would be coffee which contains caffeine and catechins, as well as other compounds that cause the beneficial responses.

Another example Gubler pointed out is CBD.The hemp industry is a good example of polypharmacology where you have a mixture of cannabinoids, like CBD, and then you have terpenes in hemp oil that combine to cause this polypharmacological response.

I think a lot of people in the nutraceutical industry dont understand it. Polypharmacology, if done right, with clinical studies, can and should be as rigorous as the mono pharmacology approach is with the pharmaceutical industry. And I think we need to be more deliberate in understanding the principles of polypharmacology and then applying them in formulations, in new ingredients that are developed, and finding synergistic combinations of existing ingredients.

Gubler said that more industry experts need to be aware of the polypharmacology method. He said if industry experts like formulators and manufacturers unified, it would be a powerful means ofimproving the nutraceutical development process in revolutionary ways.

Polypharmacology is just getting started, Gubler explained, adding that there is an estimated 600,000 species of plants on the earth and less than 5% of those plants have been actively studied for their bioactive compounds. So theres so much left for the nutraceutical industry to discover and explore.

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What the industry needs to know about polypharmacology - NutraIngredients-usa.com

5 Effective Ways To Fight Inflammation – Medical Daily

Inflammation, which is a localized physical condition that makes a part of our body feel hot, reddened or swollen, is a very pervasive health problem these days. Its also very flexible in that record, becoming a symptom of everything, from a simple allergic reaction or hormonal imbalance to a full-blown autoimmune condition.

With that in mind, however, inflammation isnt inherently bad since studies show that its actually an important process that helps our immune system in fighting bacteria and viruses. The problem with it though, starts when the problem subsides and it decides to overstay its welcome.

Thankfully, there are various ways you can do to help drive inflammation down, especially when it starts to become a pesky chore. Here are some of the best ones:

Meditation

Believe it or not, but the calming effects of meditation can help lower inflammation, due to the stimulation of the vagus nerve. So practice slow breathing a lot, youll thank yourself later.

CBD oil

Ever heard of the endocannabinoid system? Also known as the ECS, it helps fight inflammation by stopping pro-inflammatory cytokines. Thankfully, they dont have to be alone in that fight since CBD oil can help them battle inflammation. Only thing left to do is to choose whether you want it in capsule form, or the more common oil tincture.

Stimulate your vagus nerve

A cranial nerve that plays an important role in both communicating and modulating the function of our brain, liver, heart, lungs and guts, stimulating the vagus nerve is shown to help lower inflammation-related health issues. To stimulate it, you may do so via deep humming, slow breathing, singing or electrode therapy.

Drink a glass of red wine

Rich in polyphenols like resveratrol, enjoying a glass of red wine can help lower your inflammation.

Take a nap

While getting enough sleep every night should be the norm, taking a power nap that lasts for around two hours can also help reduce inflammation levels. Its also a quick refresher, and will make you feel more energized upon waking up.

Cytokines, known to promote inflammation, are increased in the bodies and brains of people who are contemplating or have attempted suicide. Photo courtesy of Shutterstock.

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5 Effective Ways To Fight Inflammation - Medical Daily

Bitfinex partners with ODEM to expand cryptocurrency and blockchain education – HedgeWeek

Digital asset platform Bitfinex and on-demand education and employment marketplace ODEM SA have collaborated to produce a new model of education on the role of digital token in the blockchain-enabled economy.

The idea is to provide an innovative token transaction simulation model, designed and operated by ODEM, using Bitfinex as its premier liquidity platform.Bitfinex and ODEM will launch a series of programmes and courses aimed at increasing the level of education of both novice and advanced Bitfinex users who are interested in obtaining more knowledge about the technical features of digital tokens. In conjunction with these educational programmes, ODEM will launch a full simulation of its education marketplace. Bitfinex will provide the liquidity for ODEM transactions, reflected through ODEMs smart contracts. This way, Bitfinex users purchasing educational programmes on the ODEM Marketplace using the same credentials as on Bitfinex will be able to view their ODEM Token transactions on Bitfinexs order book.Were excited to be the first to market with completely mirrored fiat-to-crypto trades in our education and employment marketplace, says Richard Maaghul, CEO at ODEM. Mirroring blockchain transactions allows users to view their payment activity reflected through our smart contracts in real-time and viewable through Etherscan.io. Transactions conducted by ODEMs Token simulation are fuelled by liquidity provided by Bitfinex. With their support of the overall decentralised ecosystem and focus on community-driven social impact, Bitfinex was a clear driver for us.Bitfinex users will be able to obtain access to all educational programs on the ODEM Marketplace directly from the platforms website. Bitfinex can leverage these programs to obtain a holistic view of cryptocurrency markets and trends, while also further enhancing users understanding of how the platform operates.Our collaboration with ODEM is a natural extension of our role as the premier trading platform worldwide, says Paolo Ardoino, CTO at Bitfinex. By educating more individuals on the uses and value of cryptocurrency and the vital role it plays in powering the blockchain economy, we are encouraging greater understanding and adoption of digital currencies. Were confident that through continued, dynamic and relevant education provided by expert educators on ODEMs platform, Bitfinex users will receive an advanced service offering.

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Bitfinex partners with ODEM to expand cryptocurrency and blockchain education - HedgeWeek

Venezuela to Back Its Petro Cryptocurrency With 30 Million Barrels of Oil in Reserve – CryptoGlobe

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Venezuela to Back Its Petro Cryptocurrency With 30 Million Barrels of Oil in Reserve

venezuela-to-back-its-petro-cryptocurrency-with-30-million-barrels-of-oil-in-reserve

Venezuelan president Nicols Maduro has said that the country will back its Petro cryptocurrency with 30 million barrels of oil it has in its reserves.

When the OPEC nation initially sold the Petro via its initial coin offering it stated the Petro would be backed by 5 million barrels of oil. Maduros words, Reuters reports, came as part of a renewed push to promote the oil-backed cryptocurrency, as Venezuela deals with hyperinflation and economic sanctions.

In a state television address, Nicols Maduro reportedly stated:

The inventories of crude and products in storage tanks are available for immediate commercialization ... to sustain and back the operations of the sovereign Venezuelan crypto-asset, the petro.

A previous report from Reuters showed that the initial 5 million barrels of oil said to back the cryptocurrency were from an area without infrastructure to get it out of the ground. In his speech, Maduro didnt clarify how the backing would work.

The Petro isnt currently listed on any major cryptocurrency exchanges, and its unclear whether investors can redeem it in any way with the Venezuelan government. Its crude inventories have been on the rise in recent months, as international sanctions scare off buyers from the state-run oil company PDVSA.

Over the last few months Maduro has been pushing for the Petros adoption. As covered he recently stated t has over 27,000 affiliated businesses, after last month a Venezuelan official claiming it can be used for payments at 93 different stores thanks to a new payments gateway called PetroPago.

Venezuela has even revealed plans this year to see its state-sanctioned crypto exchange CriptoLAGO release a debit card and a point-of-sale system to help the Petros use grow at retail stores.

Featured image via Pexels.

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Venezuela to Back Its Petro Cryptocurrency With 30 Million Barrels of Oil in Reserve - CryptoGlobe

This week in Cryptocurrency – Born2Invest

Crypto has had a big week, a number of big names in the finance space have weighed in on the viability of cryptocurrency and there have been a number of big regulatory shifts surrounding ICOs, while Europe is positioning itself to become the global cryptocurrency leader.

If youre in a rush the Born2Invest business news mobile app helps readers digest the crypto news summaries in small digestible chunks, helping them be up to date with the newest information in this field. Our team of experts puts the most important cryptocurrencies news at your fingertips.

Binance founder Changpeng Zhao said that President Xi Jinpings approval of blockchain would have a positive impact on the global cryptographic industry. According to Tom Lee of Fundstrat, Bitcoin will go through the same stages of development as technology companies from Silicon Valley and the Creator of Ethereum, Vitalik Buterin, believes that the shift from transaction fees, once block fees stop being issued, will create a number of significant security and verification problems for blockchains that utilize Proof-of-Work (PoW).

Joseph Lubin, founder of the Consensys startup, expressed his hope that the Chinese digital currency will interact with many blockchains, including the ethereum. While Mark Yusko, CEO of the Morgan Creek Foundation, believes that it is time to resume buying Bitcoins now. He stressed that investors should give up Amazon shares and increase capital investments in the first cryptocurrency.

John Macafee made a statement that cryptocurrency companies are not obliged to supervise everything that happens in the cryptographic industry. According to him, the fight against criminals should not fall within the remit of cryptocurrency companies.

The creator of the C++ programming language, Bjrn Straustrup, complained that his brainchild plays a key role in the functioning of Bitcoin. Speaking in Lex Freedmans podcast, Straustrup said that mining uses too much energy and that Bitcoin serves criminals. This opinion appears to be shared by the former U.S. Federal Reserve Chairman Alan Greenspan, it makes no sense for central banks to issue their own digital currency.

In contrast Bobby Li, co-founder of the Chinese cryptocurrency exchange BTCC believes Bitcoin will be able to grow in price up to $1 million, and the market capitalization of the first cryptocurrency will reach $8 trillion.

Almost half of the financial experts believe that Bitcoin will become the most efficient asset next year. This is evidenced by the results of a survey conducted by the analytical company Chainalysis.

Willy Wu, a well-known analyst, has prepared a chart that clearly shows which assets have the largest volume today. According to his estimation, more than 99% of all cryptographic assets on CoinMarketCap are illiquid.

The Weiss rating agency has published a series of posts on Twitter, where it tried to explain why the Cardano network is better than EOS.

Binance plans to add 180 new fiat currencies to its platform. Binance and HTC intend to release a cryptocurrency smartphone with Binance Chain blockchain support. The Exodus 1 Binance Edition smartphone will allow access to the decentralized Binance DEX exchange through a trusted execution environment called Zion Vault. Also, the Binance page in the Chinese social network Weibo has been blocked due to violation of the law.

Bittrex decided to return the frozen cryptocurrency funds to customers in jurisdictions where its services were banned. Bithumb Global has announced the release of a native token for the Bithumb Chain blockchain exchange. Bitfinex plans to expand its product range with options on cryptocurrency and digital staple coin secured with gold.

Several ICO-projects, which raised together about $40 million in 2017, failed to fulfill their obligations under the agreement with the U.S. Securities and Exchange Commission. The companies agreed to return the money to investors or provide greater transparency in exchange for lower fines, but failed to comply with these requirements within the specified time frame.

The French central bank is looking for a blockchain analyst and engineer to deal with digital currencies and the application of blockchain to banking services.

The European Union will become a leader in the crypto sphere if it will develop a unified approach to regulating relations in the industry, as it is stated in the study of the Association of Financial Markets of Europe. The authors of the report emphasize that European countries need to speed up the work on creating a single legal framework, as the U.S. and China also want to become leaders in this area.

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(Featured image byAndr Franois McKenzieviaUnsplash)

DISCLAIMER: This article was written by a third party contributor and does not reflect the opinion of Born2Invest, its management, staff or its associates. Please review our disclaimer for more information.

This article may include forward-looking statements. These forward-looking statements generally are identified by the words believe, project, estimate, become, plan, will, and similar expressions. These forward-looking statements involve known and unknown risks as well as uncertainties, including those discussed in the following cautionary statements and elsewhere in this article and on this site. Although the Company may believe that its expectations are based on reasonable assumptions, the actual results that the Company may achieve may differ materially from any forward-looking statements, which reflect the opinions of the management of the Company only as of the date hereof. Additionally, please make sure to read these important disclosures.

First published in coinspot, a third-party contributor translated and adapted the article from the original. In case of discrepancy, the original will prevail.

Although we made reasonable efforts to provide accurate translations, some parts may be incorrect. Born2Invest assumes no responsibility for errors, omissions or ambiguities in the translations provided on this website. Any person or entity relying on translated content does so at their own risk. Born2Invest is not responsible for losses caused by such reliance on the accuracy or reliability of translated information. If you wish to report an error or inaccuracy in the translation, we encourage you to contact us.

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This week in Cryptocurrency - Born2Invest

BITCOIN: Cryptocurrency is for criminals, says inventor of worlds leading computer code – Express

Danish computer scientist Bjarne Stroustrup invented the language C++ in 1985. Even now, 34 years on, it remains the one of the most commonly used codes woven into systems throughout the world.However, Stroustrup now says his one overwhelming regret over the last four decades is that his work went on to become the code upon which bitcoin is based. When you build a tool, you do not know how it is going to be used, he lamented.

Im very happy and proud of some of the things C++ is being used for and there are some other things I wish people wouldnt do.

Bitcoin mining is my favourite example it uses as much energy as Switzerland and mostly serves criminals.

The 68-year-old a managing director at Morgan Stanley in New York has spoken before about his dislike of cryptocurrency, but this is the first time hes expressed remorse over his code being used in the creation of BTC.

Speaking on the highly popular Lex Fridman podcast, the University of Cambridge graduate enthused over the great achievements made with computer science, but he turned his ire upon bitcoin when he discussed regrets, highlighting concern over environmental issues and criminality.

Almost half of all bitcoin transactions have, according to some studies, connections to criminal activities. It has also been suggested that almost a quarter of BTC users are also involved in illegal activity to the tune of $72 billion a year.

Bitcoin also attracts criticism for its negative environmental impact, using up a mind-boggling seven gigawatts of electricity a year and accounting for 0.21 percent of the worlds supplies.

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BITCOIN: Cryptocurrency is for criminals, says inventor of worlds leading computer code - Express

Op-ed | Living off the land: Lunar water is key to crewed space exploration – SpaceNews

The moon has formed the isolated backdrop for a new era of space exploration. As you read this, there are teams of exploration advocates around the world striving to reach its surface. This goal may be accomplished as early as next year.

This new age is one that is being led not by spacefaring superpowers seeking to fly flags and footprints but instead by numerous private companies, each vying to demonstrate their capability to fly 385,000 kilometers through the vacuous darkness of space and safely soft-land on our celestial neighbor. The rise of such companies follows the renewed focus on the moon by space agencies around the world, spurred on the by the Global Exploration Roadmap, as we prepare once again for crewed deep space exploration. This resurgence of lunar exploration has reached fever pitch and soon these private companies will provide the capability to deploy scientific and commercial payloads to various locations on the moons surface for the first time in history.

The price tag to perform such a magnificent feat of engineering? About $1 million per kilogram. Think about that for a second; thats the mass of just 1 liter of water.

As the space industry continuously vies with the worlds biggest issues for its share of public support (and funding) it is imperative that we do everything we can to lower these costs and deliver milestones that truly benefit those of us left here on Earth. So, with such price tags on our most basic amenities, how could we ever possibly afford to permanently expand humanitys presence further into space?

The answer lies in going back to the roots of human existence; living off the land. The moons barren surface was once described by Buzz Aldrin as magnificent desolation and it appears to be exactly that at first glance. But lying within the unmoving surface layers is a treasure trove of resources adequate to nurture a settlement of future explorers.

Among the plentiful resources on the moon are various metals trapped as oxides in the surface material (regolith). These oxides can be used in the coproduction of oxygen and pure metals to provide astronauts with breathable air and sturdy 3D-printed structures in which to shelter from micrometeorite impacts and the constant stream of potentially lethal cosmic rays that emanate from supernova explosions far outside our solar system.

Looking much further ahead, rare Earth metals may also be extracted for use in our advanced electronic devices or even Helium-3 for fuel in our yet-to-be-built fusion reactors. But the most immediate, and to me the most exciting, avenue for resource utilization on the moon is lunar ice.

Water has long been theorized to exist on the lunar surface due to a unique quirk of the entwined orbital geometry between the Earth and the moon. Due to this very stable set up, which has existed for billions of years, the moons axis is tilted only 1.5 degrees relative to the suns incoming rays. This means that at the lunar poles there exist regions within deep craters that are utterly untouched by sunlight.

This, coupled with the fact that there is little-to-no atmosphere, means that there are extreme temperature differences between light and dark on the moon, upward of 150 degrees Celsius. These unlit regions within craters, referred to as permanently shadowed regions, or PSRs, are now known to host vast quantities of water ice that have been lying in perfect isolation for hundreds of millions of years. Although an exceedingly difficult number to quantify, it is commonly believed that the quantity of water in these PSRs exceeds 100 million tons.

Companies and agencies around the world are already investigating if this lunar water can be successfully and efficiently harvested. If so, it will unlock untold possibilities for our future in space.

The beauty of lunar water is that it may prove to be remarkably easy to harvest with robotic technologies. ESA already has plans to demonstrate this through a proposed mission called Heracles. By utilizing a new NASA-led space station around the moon, the Gateway, which is slated for construction in 2024, astronauts can tele-operate a rover and collect lunar samples for eventual return to Earth. Whats more, many of the transportation companies that intend to fly to the moon within the next few years seek to demonstrate roving capability once on the surface. This means that within the next decade there may be tens of companies with the ability to harvest water robotically in preparation for the return of humans to the surface.

A mission profile which relies heavily on precursor robotic utilization, although perhaps not as exciting as watching a human bounce gleefully across the dusty lunar surface in low gravity, will reduce risks for astronauts. If enough water can be harvested in advance by their robotic companions, astronauts can arrive at a rudimentary base with preliminary supplies, thereby reducing the amount of propellant used at every step in the mission.

With access to lunar ice, we can finally realize our vision of sustainable, affordable expansion beyond low Earth orbit. Of course, the most obvious examples of this are purifying lunar ice through a simple boil-off procedure into drinking water. Or one could use solar arrays to harness the suns energy to electrolyze the ice and form oxygen for astronauts to breathe; a practice which is already commonplace aboard the International Space Station. Water will allow us to begin cultivating fresh food, which will have huge benefits for astronauts physical and mental health during future missions.

The list goes on. Water is even vital when not being consumed. Due to its high hydrogen content, it can be utilized as an efficient radiation protection to help shield astronauts from the never-ending stream of cancer-inducing space radiation.

In the far future, it will also be possible to convert lunar ice into liquid hydrogen and liquid oxygen to form a rocket propellant with impressive characteristics. By leveraging the moon, or more precisely cislunar space, as a refueling station on the highway to deep space it may be possible to drastically lower the price of space exploration as we would no longer have to lift hundreds of tons of extra propellant off the surface of the Earth. This point, I should note, is heavily contested due to the difficulties in storing liquid hydrogen over long durations. However, the skeptics would appear to be betting against the worlds richest man, Jeff Bezos, and his space company Blue Originit is no coincidence that their lunar lander, Blue Moon, will rely on a newly developed engine fueled by liquid hydrogen and liquid oxygen.

Skeptics aside, there is no doubt in my mind that the moon is the ideal next steppingstone on our global exploration journey. And by utilizing the available resources in-situ, we will gain the ability to greatly reduce the costs of exploring the moon and work toward a truly sustainable and permanent outpost in space. Over the coming decades, and with the right nourishment from national agencies, new deep space industries will mature, and a lunar economy will be born: an economy with lunar water at its heart.

Calum Hervieu is a mission analyst at Planetary Transportation Systems GmbH (formerly PTScientists GmbH), a Berlin-based company that aims to land a privately funded spacecraft on the moon.

This article originally appeared in the Oct. 21, 2019 issue of SpaceNews magazine.

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Op-ed | Living off the land: Lunar water is key to crewed space exploration - SpaceNews

SpaceXs Starship Craft For Space Exploration Blows Its Top During Test – Forbes

SpaceX's Starship prototypen before the explosion on Wednesday.

The top of SpaceXs Mk1 Starship appears to have blown off during a pressure test of the prototype rocket. Livestream cameras set up by third parties to watch the spacecrafts construction captured footage of the explosion.

The companys CEO and founder Elon Musk downplayed the incident, replying to a Twitter comment about what this means for the spacecrafts development by saying, This had some value as a manufacturing pathfinder, but flight design is quite different.

In an emailed statement, the company said, The purpose of todays test was to pressurize systems to the max, so the outcome was not completely unexpected. There were no injuries, nor is this a serious setback.

Starship is the space companys next-generation program for space exploration, which it intends to use to provide service to the Moon, Mars and possibly elsewhere. On a conference call organized by NASA earlier this week, SpaceX president and COO Gwynne Shotwell stated that the company could land a Starship craft on the Moon as early as 2022. Its not clear yet if this incident would impact that ambitious timeline, but the companys emailed statement indicated that its Starship team is focused on the Mk3 builds, which are designed for orbit.

This isnt the first time that SpaceX has experienced failures, either in testing or on the launch pad. It suffered a failure of a commercial Falcon 9 launch in 2016 as well as the failure of a test of its crewed Dragon spacecraft earlier this year. But the company tends to take such failures in stride, seeing them as part of the iterative process to improve its products.

For example, the company first successfully landed the first stage of a Falcon 9 rocket in 2016, but not until after multiple failures that the company celebrated in a highlight reel called How Not to Land an Orbital Rocket Booster on YouTube. That video has since been viewed over 14 million times.

This article has been updated since publication to include comment from SpaceX.

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SpaceXs Starship Craft For Space Exploration Blows Its Top During Test - Forbes

The Most Exciting Moments About Space in 2019 – Interesting Engineering

2019 has been a very exciting year for space-related events. Here we explore some of the most notable space missions of the past and explore the most notable and exciting space moments of this year.

Trust us when we say the events detailed below are far from exhaustive.

RELATED:5 TECHNOLOGY TRENDS TO WATCH IN 2019

We are living through an exciting and vibrant time in space exploration. Events are happening at a break-neck speed, and news change almost daily.

For this reason, any declaration of the "latest" space mission would quickly become redundant.

There are many current and in-development space missions by various private and public space agencies around the world. For up to date news on missions it is recommended you sign up to and follow each organization on social media and via their websites.

But, taking NASA as an example, their website is the best place to find the latest news of their ongoing and planned space missions.

This is something of a personal choice, but there are some very significant events in space exploration over time. Some notable milestones in our exploration of the heavens are as follows:

1. The very first satellite in space - In October of 1954, the Soviet Union launched humanity's first artificial satellite in history - Sputnik 1. This was not only a triumph for humanity in general but it almost single-handedly led to the creation of NASA.

2. The first human in space - Another amazing achievement by the Soviet Union. In 1961,cosmonaut Yuri A. Gagarin, onboard the Vostok 1 spacecraft, became the first human in space.

3. The first lunar landing - In a classic game of one-upmanship, NASA pulled out all the stops to plant the very first human beings on the Moon. Apollo 11 stands as one of man's greatest technological achievements of all time.

4. The Hubble Space Telescope - Launched in April of 1990, the Hubble Space Telescope has been a gift that keeps on giving. Offering unprecedented views of the universe around us, Hubble has led to many discoveries beyond all the hopes and dreams of its designers.

5. The first private spacecraft - In June of 2004, SpaceShipOne was designed and built by an aerospace development company known as Scaled Composites. Flown by a South-African born American, it actually managed to fly past the boundary of space.

This laid the foundations for the current explosion in private enterprises turning their hand to space exploration. As more and more private enterprises enter the market, humanity's future in space will undoubtedly get better, cheaper and more accessible to private citizens in the future.

Here is a summary of the past and future events in all things space in 2019. A lot has happened this year and, as such, the following is just a hand-picked sampling of the most notable events of the year.

On New Years Day of 2019, NASA's New Horizons spacecraft completed its journey to Ultima Thule. This was the furthest object that we've ever managed to visit in our Solar System.

Scientists pored over the first images received but will have to wait for a little longer for the rest of the probe's data to arrive on Earth.

China was also hoping to land its Chang'e-4 lander on the far side of the Moon in January. On the 4th of the month, all their hard work paid off with the lander touching down on the mostly unexplored side of the Moon.

The probe returned some interesting images and very exciting data for astrophysicists to sift through at their leisure.

NASA's Mars Insight Lander's HP3began drilling the Red Planet's surface at the beginning of the month. They plan was to reach about 5-meters in-depth to take important measurements on the internal surface temperature of the planet.

But, for some as yet unknown reason, it hit technical issues and couldn't penetrate beyond 30 cmin depth.

This month, Israeli private non-profit, SpaceIL launched their first Moon lander onboard a SpaceX Falcon 9 rocket. The team hoped to plant an Israeli flag and make some magnetic readings if they successfully completed their landing sometime in April of 2019 (more on this later).

The Moon itself also made a show for Earth-bound spectators this month. On the 19th of February, it passed closer to the Earth than usual to provide a Supermoon in the night's sky.

This same month, the Juno probe was planned to make a sweeping visit to Jupiter. True to form, the probe got some great images of the gas giant. Further flybys were also scheduled for May, July, and September of the same year.

Japan also made its attempt to collect samples from the asteroid Ryugu this month. The probe called Hayabusa2, successfully fired a pellet at the asteroid's surface to gather some of the asteroids material for analysis.

Further sampling attempts were planned for later in 2019.

In March, SpaceX launched and tested one of their crewed Dragon 2 spacecraft in the rigors of space. the craft, called Demonstration Mission 1 (DM-1), wasn't actually crewed but the data they gathered would guide future crewed flights.

After months of delay, it successfully reached orbit and made its way to the ISS.

Boeing also planned to test its brand-new CST-100 Starliner this month. The craft is currently under development to provide a vehicle to transport crews and materiel to the ISS.

Sadly it was plagued with delays and rescheduled for April.The test was to be uncrewed, and following its successful completion, a crewed test would be attempted in August of 2019.

This has since been revised again, with current estimates for an unmanned test flight in December of this year.

April started out brilliantly with a close approach of NASA's Parker Solar Probe to the Sun. This followed other approaches in late 2018 and will not be the last for many years to come.

This month also spelled the end of a contract with Russia and NASAfor delivering people and stuff to the ISS using their Soyuz spacecraft. This contract was established following the unfortunate retirement of their own Space Shuttle program in 2011.

For this reason, NASA has been busy working with Boeing and SpaceX to find an alternative logistics solution. But it was announced in February of 2019 that NASA may still consider using Russian Soyuz craft until alternatives are found.

April was not the best month for the team behind the Israeli gambit to put a probe of their own on the Moon. SpaceIL, a private venture, had teamed up with Elon Musk's SpaceX to attempt to plant an Israeli flag on the lunar surface.

Sadly, all contact was lost with the Beresheet lunar lander in the afternoon of April the 11th as it crashed into the Moon's surface. Despite the setback, the team is hoping to send a second Moon lander in the not too distant future.

Also this month, SpaceX had hoped to make a test flight of their Starship craft. "Starhopper" managed to perform a short, tethered, engine test leading to future plans for untethered testing later in the year.

SpaceX also successfully tested another of its Heavy Falcons this month. Not only was the launch a success, but they also managed to recover all three of its booster rockets.

May was a quieter month for space exploration. But there were some notable events.

The first was the Eta Aquarid meteor shower on the 6th of May. This is a fairly regular event that peaks around early-May every year.

The meteors are actually debris leftover from Halley's comet when it passes close to Earth on its rare visits.

On a more dramatic note, SpaceX's Dragon Crew Capsule was confirmed to have exploded during another test this month. This was the very same capsule, DM-1, that had proved successful back in March of 2019.

Astronomers also released an interesting report on the recent asteroid impact on the Moon's surface this month. Leaving a crater about 15-meters wide, the collision was reported in theMonthly Notices of the Royal Astronomical Society.

In other news, a rocket designed by a team of students from the University of Southern California (USC) Rocket Propulsion Lab (RPL) successfully launched a small rocket that reached the edges of space. The tiny 8-inch (20.3 cm) diameter, 13-foot (3.96 m) tall rocket, called Traveller IV, is the first student-designed craft to ever do so.

Towards the end of the month, an asteroid also made a 'close' approach to our beloved home planet. The mile-wide (1.6 km) rock with its own small moon, passed around 3.5 million miles from Earth.

Also this month, a Soyuz rocket was hit by lightning with no ill-effects on the 27th of May.

NASA's Mars Reconnaissance Orbiter took some impressive images of Mars this month. Using it'sHigh-Resolution Imaging Science Experiment(HiRISE), the orbiter captured images of an impressive and supposedly newly formed crater on Mars.

Also this month, NASA announced that their Curiosity rover had detected high levels of methane in the atmosphere of Mars. This sparked much debate about the likely source and potential for finding life.

By far, one of the most spectacular Space events this month was the Strawberry Moon. Many people around the world who were able to catch a glimpse were left awestruck around the world.

In the middle of June, a new study was released that pointed to the fact the Europa, one of Jupiter's moons, might have saltwater comparable to Earth's oceans under its icy crust. Using data fromHubble Space Telescope Imaging Spectograph (STIS)the team reported they've picked up the spectral signature of irradiated sodium chloride.

This month, SpaceX successfully launched another Falcon Heavy Rocket. What was different about this event was the fact that, for the first time, the company successfully resued one of their booster rockets from previous launches.

But it came at a cost. They failed to recover the central core unit.

Towards the end of June, scientists announced they had found an exoplanet that bears a striking resemblance to Earth.TheCARMENESsurvey team announced that the planet that orbits Teegarden's star, the 24th closest star to our own, is only 12 light-years away.

Airing on the 29th of June, the "Apollo 11" documentary premiered on CNN. The film was edited and directed by Todd Douglas Miller and was compiled from hours of real NASA archive footage of this history-making event in human history.

Earlier in the month, researchers revealed that there may be a way for black holes to form without the need for a collapsing star. The theory, called 'direct collapse' was proposed by two researchers at Western University in Ontario, Canada.

Also at the start of July, the first total eclipse of the Sun since 2017 was enjoyed by onlookers in South America. Parts of Chile and Argentina were treated to one of the most spectacular events the heavens have to offer.

Researchers also put to bed any notion that the now infamous'Oumuamua asteroid was actually an alien spaceship. Much to the disappointment of many excited members of the public.

Deployed into space in late June, the Carl Sagan inspired LightSail2 solar sail spacecraft was reported to be operational and ready to deploy its innovative propulsion device (which it did later in July). If successful, this will provide a proof of concept for the tech for future applications.

In mid-July, a United Arab Emirates spy satellite failed to make it into orbit and crashed into the Atlantic Ocean. It appears a serious rocket failure occurred only two minutes after liftoff.

The bad news was not exclusive to the UAE in July. The European Galileo GPS satellite system suffered a major outing in July too. Costing over 3 Billion Euros to date, a mysterious technical issue left Europe relying on American satellites until service was restored.

In late July, India also made its own attempt to launch a Moon lander and rover to the Moon. CalledChandrayaan-2, it had originally been planned for launch in January but was delayed for several months following technical issues.

In early August, researchers revealed they had detected the highest energy photons ever recorded from the Crab Nebula. The team was unable to explain how they are created by the nebula, however.

Also in early August, NASA announced they had found a new "Hot Earth" exoplanet. The space agenciesplanet-hunting satelliteTransiting Exoplanet Survey Satellite, orTESS for short, spotted the new planet as well as two others orbiting its parent star.

Also this month, an "Ultra-Massive" black hole was discovered in the universe. With an estimated mass of over 40 billion suns, this new black hole is one hell of a monster.

SpaceX's space-bound Roadster made it's the first orbit of the Sun this month. Launched onboard a Falcon Heavy rocket test in February of 2018, the Roadster has been a tour of our solar system over since.

It won't come close to Earth again until November 2020. We say close but it'll be somewhere in the order of32.2 million miles (52.8 million km) away by then.

On the subject of SpaceX, a Chinese private space company, LinkSpace, also announced the third successful launch of its reusable rocket. The Beijing-based company reported it reached 300-meters in height before safely returning to its launchpad 50 seconds later.

Also on the subject of SpaceX, Elon Musk announced it might be a good idea to nuke Mars to prepare it for human settlement. Although it might sound a little gung-ho, there is some merit to his suggestion.

Back onto the subject of black holes, scientists revealed they had evidence of one swallowing a neutron star. The event appears to have occurred 900 million years ago,and must have been an impressive thing to have seen if you were close enough at the time.

On a lighter note, the hyped "Storm Area 51 Event" that was planned on the 20th September 2019, turned out to be a bit a flop. But it was fun to watch some of the attendees attempting to "Naruto run".

In September, SpaceX revealed its candidate landing sites for future Mars missions by the private space company. These sites appear to have been penciled in for their Starship once its development is complete.

Probably the main news event this month was the announcement of a million-dollar prize for the first image of a black hole. The team of eight at EHT split the 3 million prize between them.

On a completely different subject, researchers also announced they had made cement in space for the very first time. A recent series of experiments on the ISS discovered it was actually possible to get cement to solidify in microgravity.

India's Chandrayaan-2arrives at the moon but contact was lost with its lander, called Vikram, creating serious doubts about the mission's success.

The Indian Space Research Organisation (ISRO), the team behind the apparently ill-fated Vikram Lunar landerdid later announce that they had found it. The team was still unable to make contact, but they announced that it appeared to be operational and was expected to complete its planned 7-year mission.

Water vapor appears to have been discovered on an exoplanet for the first time, according to findings released in September. What's more, the exoplanet also appeared to be in the habitable zone of its parent star - - could it harbor life?

Our solar system was visited by another interstellar tourist in September.C/2019 Q4,believed to be a comet, was spotted by an amateur astronomer and got many stargazers very excited indeed.

Just at the close of the month, Elon Musk announced that he wants to put SpaceX's "Starship" into orbit within the next six months. Whether they can achieve it or not is anyone's guess.

There was some very exciting news earlier this month. Scientists announced that they had potentially discovered the existence of the basic ingredients for life on Saturn's moon Enceladus.

NASA also announced earlier this month that the Juno probe was ready to jump Jupiter's shadow. The maneuver was needed to prevent the probe's solar panels from being obscured by the gas-giant blocking the sun.

Astronomers announced they had found twin baby stars growing amongst gas and dust in October.The remarkable find sheds new light on the earliest phases of the lives of stars.

There was also some good news for people hoping to one day colonize the Moon. Oxygen and metal were found to be present in Lunar soil. Analysis of samples of regolith found that it was around 40-45% oxygen by weight.

A NASA engineer revealed information about a new form of propulsion that could achieve 99% the speed of light. Called an EmDrive, it requires no propellant and could prove to be the future of space exploration.

Scheduled for launch between October 15th and November 14th, the ESA plans to launch their own planet-hunting mission. CalledCHEOPS(Characterising Exoplanets Satellite), it will look for planets orbiting bright stars close to our Solar System.

Uranus(don't, just don't) is also scheduled to make its closest approach to Earth this month. This will mean it will look a little bigger and brighter than usual.

On the 2nd of November, the Moon will pass in front of the ringed planet Saturn. skywatchers in New Zealand will get the best views but it should still be impressive from other locations around the Earth.

On the same day,Northrop Grumman will launch the Cygnus NG-12 cargo mission. It will resupply the ISS.

On the 11th of November, Mercury is set to transit the Sun as viewed from Earth.This won't happen again until 2039 so be sure to check it out.

If you are hoping to see this amazing event, make sure you use special equipment. It is, after all, extremely dangerous to look directly at the Sun.

Sometime in November, SpaceX is also planning to send its first crewed Crew Dragon mission to the ISS.This will be the Crew Dragon's first test flight with astronauts on board following the uncrewed DM-1 mission in March.

SpaceX will need to ensure any issues they've uncovered with DM-1's untimely explosion earlier in the year have been rectified.

During the festive season, Japan'sHayabusa-2 spacecraft is scheduled to depart the asteroid Ryugu andreturning to Earth in December 2020. It will bring its valuable cargo of samples for rigorous analysis on Terra Firma.

December also means it's time for theGeminids meteor shower. This shower is caused by debris from an asteroid called 3200 Phaethon.

On boxing day 2019, we will be treated to a rare annular solar eclipse. But only, that is, if you are in the right place at the right time.For an annular eclipse to happen, the Moon has to be at its furthest from the Earth, so it doesn't quite cover up the Sun.

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The Most Exciting Moments About Space in 2019 - Interesting Engineering

NASA’s Orion spacecraft to arrive Sunday and undergo environmental testing in Sandusky – News 5 Cleveland

SANDUSKY, Ohio The next stage of human space exploration will start this weekend right here in Ohio at NASA's Plumbrook Station in Sandusky when the Artemis 1 Orion spacecraft arrives for environmental testing.

According to NASA, the Artemis 1 Orion spacecraft is "built to take humans farther than theyve ever gone before. Orion will serve as the exploration vehicle that will carry the crew to space, provide emergency abort capability, sustain the crew during the space travel, and provide safe re-entry from deep space return velocities."

Artemis 1 Orion left the Kennedy Space Center in Florida on Thursday and it and its crew will arrive at Mansfield Lahm Airport, 2000 Harington Memorial Road, on Sunday afternoon. The Artemis I Orion will be delivered via NASA's Super Guppy aircraft.

The airport will be open to the public for anyone interested in watching the spacecraft being unloaded. Anyone who plans to attend should arrive no later than 1:30 p.m. The Super Guppy is scheduled to land at 2:30 p.m.

Astronaut Doug Wheelock will make an appearance at the main airport terminal office and be available for autographs from 4 to 4:30 p.m. Additionally, there will be exhibits and activities from noon to 5 p.m.

NASA will use a 135-foot-long truck to take the Artemis I Orion to its Space Environments Complex (SEC) at the Plumbrook Station. According to the agency, the SEC "houses the largest and most powerful space environment simulation facilities in the world."

To see a virtual tour and find more information about NASA's Plumbrook Station, click here.

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NASA's Orion spacecraft to arrive Sunday and undergo environmental testing in Sandusky - News 5 Cleveland

Out Of This World: Is Space A New Twist On Frontier Investing? – MarketWatch

The term frontier markets typically refers to international diversificationthat is, investing outside United States bordersand specifically nations that are developing economically and newly open to investment. But what if we were to widen that definition out a bit, from international to interplanetary? Would that be the final frontier in investing?

Richard Bransons space-tourism company, Virgin Galactic Holdings SPCE, -9.85%, had its initial public offering (IPO) in the last week of October 2019, making it one of the few pure-play, publicly traded companies in the space industry. If you want to hitch a ride, a single round trip will set you back $250,000and no, theres no one-way rate.

Is that price tag out of your budget? There are other ways to push toward the heavens, namely by launching your portfolio into space.

Michael Fairbourn, education coach at TD Ameritrade, noted there are two ways to look at investing among the stars: Space tourism and space exploration. Space tourism companies such as SPCE are officially called suborbital space tourism because they remain in the earths atmosphere. The privately held Blue Origin, owned by Amazon.com, Inc. AMZN, +0.63% founder Jeff Bezos, is in the space tourism business but is also developing a variety of technologies, including vehicles to access suborbital and orbital space.

The second type of space-related investing focuses on traditional space exploration that goes beyond the earths atmosphere. According to Fairbourn, the driving force for space exploration investments is what the National Aeronautics and Space Administration [NASA] invests in. "It has the knowledge base and the spending. But the funny thing is, SpaceXs activity is what really prompted NASA to get back on board and start looking again at exploration, Fairbourn said, referring to the company owned by Tesla Inc TSLA, -6.14% founder Elon Musk.

Privately held SpaceX falls into the space exploration category because it aims to deliver satellites into space. The company received Federal Communications Commission (FCC) approval in March 2018 to deliver 4,425 satellites into space. In October, the company and the FCC filed paperwork for another 30,000 satellites with the International Telecommunication Union, a United Nations entity.

With so many satellites approved for launch into space, interested investors may want to look at companies manufacturing satellites. There are four publicly traded companies in this industry: ViaSat, Inc. VSAT, +0.48%, Intelsat SA I, +0.57%, Iridium Communications Inc IRDM, -1.75%, and Teledyne Technologies Inc TDY, +0.99%.

Another category for space exploration is companies involved in rocketry, which delivers both space tourists and payloads into orbit. Some names better known for their work in the defense sector spring up here, including Northrop Grumman Corporation NOC, +0.27% and Lockheed Martin Corporation LM, +0.31%. Some of these companies are devoting significant research to rocket science, such as LMT, which gets 18% of its total net sales from space.

There are fewer of these companies, but it could potentially be a growing division because of what NASA is looking to do with increased exploration, Fairbourn explained. But he was quick to add that the outlook could change at any time.

Boeing Co BA, +1.34% also has significant money tied up in space. The firm is creating the X-37 Orbital Test Vehicle as well as the Space Launch System, which is designed to carry people and cargo into deep space.

Not a recommendation. For illustrative purposes only.

NASA is also looking at moon exploration. Maxar Technologies Inc MAXR, +3.00%, a newer company in the space industry, was awarded the first propulsion system contract from NASA for the Artemis program that aims to land the first woman and the next man on the moon by 2024. MAXRs system drives the spaceships to the moon and navigates back to Earth. The firm is also assisting in the development of the Orion Multi-Purpose Crew Vehicle, a U.S.-European spacecraft.

Another smaller company involved in the moon mission is Aerojet Rocketdyne Holdings Inc AJRD, +1.06%, which develops propulsion and power systems for space vehicles.

Some companies are using their space ties to help push boundaries back home on terra firma. Sports equipment and apparel maker Adidas (otcmkts:ADDYY), for example, is launching an effort with the International Space Station to test productsincluding sneakers, soccer balls and compression garmentsin a gravity-free environment, in hopes of optimizing performance.

Speaking of apparel, astronauts cant go into space without protective gear. Earlier this year, SPCE teamed up with Under Armour Inc UAA, +2.59% to supply passenger outfits. And for the rest of us? News reports mention that UA said it would offer a capsule collection in 2020 featuring flight jackets, base layer pieces, and hoodies to wear on Earth. So even if you cant afford $250,000 for a trip to space, you can go boldly and dress like youre taking a suborbital vacation.

And who knows? It was only a generation ago that intercontinental air travel was a luxury reserved only for the well-heeled among us. Perhaps by the end of the next decade, well all be accustomed to standing in line at the Space Transportation Safety Administration, removing our moon boots as we walk through the X-ray machine, and grabbing our assigned seats, preferably not middle seats in the coach section.

Image by Free-Photos from Pixabay

2019 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

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Out Of This World: Is Space A New Twist On Frontier Investing? - MarketWatch