Ambrosia Is Back to Selling Transfusions of Young People’s Blood

Ambrosia Health, the

Ambrosia Health is back.

Following a brief shuttering — and then a rebranding effort during which it was known as Ivy Plasma — the “young blood” clinic has gone back to its roots: selling plasma sourced from the blood of 16- to 25- year-olds to healthy patients who believe the transfusions can give them ill-defined health benefits.

“People really like the Ambrosia name and brand, so Ambrosia is going to continue,” Ambrosia founder and young blood advocate Jesse Karmazin told OneZero. “The resounding response from people wanting to sign up was, ‘keep things the same.’ So that’s what we’re going to do.”

With the return to its original branding, Ambrosia is also embracing a new business model.

When it was Ivy Plasma, the clinic offered transfusions in San Francisco and Tampa. It since shuttered the clinic in Tampa, but Karmazin told Futurism that Ambrosia will ship plasma directly to any customer’s doctor so they can get their dose of young blood without having to fly to California.

“We use overnight shipping to deliver the plasma to patients’ doctors offices, and provide training for the doctors to infuse it,” Karmazin told Futurism last month. “This way, the number of patients we are able to serve has increased dramatically. I don’t operate a blood bank.”

Ambrosia’s checkered, on-again-off-again status was spurred by an FDA statement issued in February in which the regulatory agency warned that transfusions of young blood didn’t have any of the health benefits — especially enhanced youthfulness, improved longevity, or reversed memory loss — that advocates claimed it did.

In slightly more words, the FDA essentially called young blood transfusions dangerous scams.

Because of the FDA warning, Karmazin’s clinic offered off-label treatments when it resurfaced as Ivy Plasma. That meant that customers could get their treatments if they desired, but they did so at their own risk and then-Ivy Plasma wasn’t legally permitted to claim it would do them any good.

That practice continues today in the newly rebranded Ambrosia, according to OneZero. But the clinic’s updated website includes more details about the treatment.

“Our treatment has been found to produce statistically significant improvements in biomarkers related to Alzheimer’s disease, cancer, inflammation, and stem cells in our clinical trial,” the website reads. “Patients have reported subjective improvements in athletics, memory, skin quality, sleep, and other areas.”

When asked whether the FDA’s rules had grown more lenient, Karmazin told Futurism he had consulted with the agency as well as “a number of lawyers” and wasn’t worried about the claims made on his website.

“I’m comfortable with going ahead and offering this treatment commercially to patients,” he told OneZero. 

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Scientists Detect Huge Thermonuclear Blast in Deep Space

NASA scientists detected a thermonuclear explosion in space, which they believe was caused by a fusion reaction on the surface of a pulsar.

Big Boom

NASA recently detected a massive thermonuclear explosion coming from outer space.

The culprit seems to be a distant pulsar, the space agency reports, which is the stellar remains of a star that blew up in a supernova but was too small to form a black hole. NASA spotted the burst because it sent out an intense beam of x-rays that got picked up by the agency’s orbital observatory NICER.

All in all, it serves as a potent reminder: space is an extremely dangerous, extremely metal place.

Cosmic Annihilation

The August explosion released in 20 seconds the same amount of energy our Sun would need 10 days to unleash, according to research published in The Astrophysical Journal Letters last month.

“This burst was outstanding,” NASA astrophysicist Peter Bult, who led the research, said in NASA’s statement. “We see a two-step change in brightness, which we think is caused by the ejection of separate layers from the pulsar surface, and other features that will help us decode the physics of these powerful events.”

Space Forensics

Astronomers think the thermonuclear explosion was caused by helium that sunk beneath the surface of the pulsar and fused into a ball of carbon.

“Then the helium erupts explosively and unleashes a thermonuclear fireball across the entire pulsar surface,” NICER head Zaven Arzoumanian explained.

READ MORE: Scientists Detect Huge Thermonuclear Blast in Deep Space [NASA]

More on space: Pulsar Finally Found in the Andromeda Galaxy

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The CDC Says It Really Knows What’s Causing “Vape Lung” This Time

New CDC research solidifies scientists' hunch that a compound called vitamin E acetate is causing the ongoing

Finally, the government says it’s pretty sure what’s behind the mysterious “vape lung” epidemic that’s been spreading across the country, affecting more than 2,000 people and killing at least 39.

A compound called vitamin E acetate has been found in all 29 lung fluid samples taken by the U.S. Centers for Disease Control and Prevention (CDC), The Washington Post reports. And while the CDC was looking for a wide range of other toxins and dangerous compounds, it didn’t find any in those particular samples.

The FDA first identified vitamin E acetate as a possible cause for vape lung back in September. The compound, which WaPo reports is used as a cutting agent in black market THC vapes, is considered safe to eat and touch. But scientists have a poor understanding of what vaporized vitamin E acetate does when inhaled.

The CDC research strengthens the vitamin E acetate hypothesis because the 29 lung fluid samples came from people in 10 U.S. states, helping to rule out other, more local causes for infections. Still, it doesn’t serve as a definitive explanation for vape lung.

“While this is a big step in helping us understand what may be causing these injuries, these findings do not rule out the potential for other compounds or ingredients as contributing factors,” public health expert Scott Becker, executive director of the Association of Public Health Laboratories, told WaPo. “There may be more than one cause of the outbreak.”

Still, CDC principal deputy director Anne Schuchat told WaPo that the research paints vitamin E acetate as “a very strong culprit of concern” for vape lung. Even if other factors are at play, that knowledge could help prevent the outbreak from spreading even farther.

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‘Midway’ review: Celebrating heroism with an epic | Movie-reviews – Gulf News

MID_D36_11971.NEF Image Credit: Reiner Bajo

Midway is so square, so old-school and old-fashioned, it almost feels avant-garde. Ambiguity is not its goal, nor is nihilism its motivating philosophy. It aims to celebrate heroism, sacrifice, determination and grit, and if you dont like that it really does not care.

Though its appearing some 70 years after the epochal Second World War battle it re-creates and more than 40 years after a Hollywood film with the same name on the same subject this Midway, as directed by Roland Emmerich and written by Wes Tooke, pays no attention to the notion that times have changed.

This is a film where men stand on top of bars when they have important speeches to make, where dialogue like thats the bravest damn thing Ive ever seen and lets take it upstairs to the old man is thick on the land, and an officer who neglects his wife to help fight the war promises he will spend the rest of my life making it up to her.

Though it is unlikely to win any awards for its words, Midway has two things going for it. Its based on the exploits of real men who did truly heroic things in a battle that changed the direction of the Pacific War, and it has Emmerichs gift for epic images.

A director best known for science fiction extravaganzas like Independence Day and The Day After Tomorrow (though he also helmed the Revolutionary War historical drama The Patriot), Emmerich knows his way around stirring visuals.

Led by cinematographer Robby Baumgartner and production designer Kirk M Petruccelli, the Midway visual team managed to convincingly re-create nautical action, complete with swooping planes and massive aircraft carriers, on a soundstage surrounded by blue screen walls.

Although the 1976 Midway boasted many stars including Charlton Heston, Henry Fonda, James Coburn, Glenn Ford, Robert Mitchum, Toshiro Mifune and more this years version takes a different tack.

The bigger stars on the marquee do cameos as Navy bigwigs (Woody Harrelson is Admiral Chester W Nimitz. Dennis Quaid is Admiral William Bull Halsey) while solid young actors including Ed Skrein, Patrick Wilson, Luke Evans, Nick Jonas and Mandy Moore carry the brunt of the dramatic action.

Also noteworthy is that the filmmakers have taken pains to present the Japanese in as even-handed a way as possible. In fact Midway begins with a 1937 heart-to-heart chat that starts in subtitled Japanese between Admiral Isoroku Yamamoto (Etsushi Toyokawa) and Tokyo-stationed US Naval Intelligence officer Edwin Layton (Wilson).

Japan is at a crossroads, the admiral, whose life has been threatened for being too moderate, tells Layton. Dont push us into a corner.

Cut to 1941 December 7, to be exact where the Japanese attack on Pearl Harbor and, in particular, the sinking of the battleship USS Arizona are re-created with considerable oomph.

At sea nearby is the massive aircraft carrier USS Enterprise, home base to hot dog pilot Dick Best (Skrein), a gum-chewer from New Jersey whose gifts as an aviator are overshadowed by a hot-headed desire to throw caution about the Japanese fleet to the winds and put a 500-pound bomb down their smokestack as soon as possible.

While Best, aided by ever-understanding wife Ann (Moore), has to learn to moderate his temper to become a better leader of men, Layton, now stationed at Pearl, has to convince his dubious superiors he knows what hes talking about when he insists that the Japanese are up to something involving the tiny but strategic atoll known as Midway.

Though the exploits of the Navy pilots, particularly the remarkable ones of the real-life Best, are at the heart of Midway, the film also finds the space to include both submarine action and the raid on Tokyo led by Army Lieutenant Colonel James Doolittle (Aaron Eckhart.)

In fact, in an attempt to convey multiple stories, Midway introduces so many characters it can be difficult to track who is who and hard to figure what the exact story of the battle is.

The fact that heroes were involved, however, is the one thing that does come through loud and clear, and that, Emmerich and company no doubt feel, is the thing that really counts.

Midway is now showing across the UAE.

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For Artist Tobias Spichtig, Shopping is a Way of Sculpting – Interview

Should a luxury store design offer shoppers an idealized vision of the human experience? The Swiss artist Tobias Spichtig doesnt think so. Spichtig has taken his series of Gheist sculpturesethereally thin, human-like figures that at first glance may appear to be some sort of demented mannequinto Balenciaga, a perfectly dystopian complement to the stores new design. With tubular aluminum railing, suede couches, and cloudscapes projected onto the ceilings, the new stores carry the aura of a movie set in which a group of models flee a climate change-destroyed earth in a minimalist escape pod.

This strain of Balenciaga nihilism, designed by Demna Gvasalia and Niklas Bildstein Zaar, can be experienced at the stores new flagship on Madison Avenue, the first to include a sculpture by Spichtig. Aside from the flagship, Spichtigs sculptures will also be featured in new stores in Paris and London, among other cities. To celebrate Spichtigs love of the macabre (and luxury goods), Interview spoke with Spichtig over the phone from his studio in Berlin about his sculptures, the art of shopping, and the Grim Reaper.

PATRICK MCGRAW: You once told me that you starting making the ghost sculptures because you felt lonely and wanted to fill your apartment with friends.

TOBIAS SPICHTIG: Yeah, I was living on my own and thought it would be nice to have people around all the time. So I took these clothes that people had left in my apartment after a New Years party. You know that feeling you get when there are all these clothes lying around, that theyre kind of looking at you? Or you think for a second, Oh shit, thats a person? So I made the first one with these clothes and kept making more.

MCGRAW: Did you throw more parties to get more clothes?

SPICHTIG: I eventually started going to thrift stores to get more clothes, so the sculptures were also a bit of an excuse to go shopping. I had always wanted to be into fashion but I didnt really have money. So I told myself I could buy clothes because Im making works out of them.

MCGRAW: So if clothes are the artists materials, then buying clothes is like sculpting

SPICHTIG: Well, if youre doing figurative sculpture, and you want to make a body, the proportions are already built into the clothes. Clothes are also empty, and I wanted them to stay that way. When I started making them, there were mannequins in every museum show. But the ghosts are kind of the opposite of mannequins. Theyre just empty clothes. I wanted them to be ghostly, or like the Grim Reaper.

MCGRAW: Did you shop for a specific type of clothes?

SPICHTIG: Mostly clothes that I would wear. Then theres certain things you cant buy. I mean if you buy shorts, then its going to look like somebody cut their legs off, you know? So its kind of specific.

MCGRAW: And you started pouring resin all over them.

SPICHTIG: My dad built airplanes, and a lot of the parts they used were with this type of resin that you mixed with fiberglass, like for sailing boats or surfboards. I called up this company that my dad used to work with. The best resin to use with cotton is the same resin they use with sports equipment and airplanes. So with the ghosts, Im drenching resin on clothes, whereas with planes, you would drench it on fiberglass.

MCGRAW: Theyve traveled such a long distance from being objects in your living room to being in luxury retail stores. Do you think thats changed the sculptures?

SPICHTIG: In a way, its the success story of the ghosts. First they were from a thrift store, and now theyre luxury clothes. But to me, they havent changed at all.

MCGRAW: It almost turns the ghosts into one big performance. Once they were poor, and now theyve become rich.

SPICHTIG: But theyre still doing the same act. Theyre just annoying and standing around and nobody knows what theyre there for. In a strange way, theyre unspectacular. Because theyre empty. Theyre really empty. I like that.

MCGRAW: How do you think the average shopper is going to interact with the sculptures?

SPICHTIG: I think the average shopper would look at them the same way they might look at any other sculpture, person or clothes. Some people might not even notice them.

MCGRAW: I feel like that would upset most artists.

SPICHTIG: Well of course they would notice them, but the ghosts are like an object, but also nothingBut because theyre nothing, they become more than nothing. People fill them with love because they cant wear them.

MCGRAW: What does it say to show the same works in a store after a gallery? Is a gallery just a store anyway?

SPICHTIG: Yeah, except in a store you cant buy the sculptures, and in a gallery you cant buy the clothes a gallerist is wearing. But its the old question of money and art. And I dont think you can have an opinion on money and art because thats like having an opinion on water.

MCGRAW: Is there a relationship between the fashion of your sculptures and your paintings? They often include things like models, clothes, or sunglasses etc.

SPICHTIG: Yeah, its just whats around. Its what people do, and what they wear. With the sunglasses youre not sure if the painting is looking at you, or youre looking at the painting. My neighbor also has an amazing sunglasses collection. But the painting could just as easily be a flower, but a flower doesnt look at you.

MCGRAW: Do you believe in ghosts?

SPICHTIG: There are all these chapels around where I grew up that are from medieval times, and they all had these bone walls and sculptures of death and monks and so on. All of these sculptures looked like ghosts and they had this crazy presence that came from an emptiness that they had. Not in a scary way, but more in an elegant way. They were also kind of funny actually. So I wanted to recreate that presence, only with sports clothes.

MCGRAW: Humor plays a big part in your work, although I have trouble identifying it directly. Its just kind of there

SPICHTIG: Well, whenever I try to be serious, people think its funny. Serious things are always funny.

MCGRAW: So the Grim Reaper is like a comedian.

SPICHTIG: If you stand on a stage, youre already funny. If you really stand for something, its always going to be comical. And of course, the Grim Reaper is the last one standing.

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Review: Its The End of the World, and Youll Know It – The New York Times

Season 2, which continues the story past the end of the graphic novel, is haunted by those events in a literal way: They keep flashing onscreen, in the jagged, agonized memories of Alyssa and James (yes, hes alive). Its two years later, but neither can move forward from what were the most horrible and, in the unexpected closeness they shared, the happiest moments of their lives.

It might be the biggest spoiler to say that this eight-episode coda involves them finding their way back to each other and figuring out how to express their feelings despite their terminal awkwardness and protective armor of nihilism. But what else would it be about? To complicate the process, Covell introduces a third young character, a woman named Bonnie (Naomi Ackie), who like Alyssa and James has been warped by the harsh indifference and creepiness of the adult world.

Bonnies damage intersects with that of Alyssa and James, and she joins them in a violent misadventure that recapitulates some of the motifs of the first season aimless road tripping through a backwoods British countryside reminiscent of Twin Peaks, severe harm to an adult male who probably deserves it. The shows attitudes and comic strategies are still in place, too, with the not-too-subtle punch lines delivered in an affectless deadpan and the reflexive undercutting of sincerity or sentiment.

Its all still amusing, and the notes of strangled romanticism and just-perceptible nobility are still in place. But the plot doesnt have the momentum and the crazy energy it did the first time around, and its harder to ignore the shows calculating nature: how it uses Alyssa and Jamess interior monologues to tell us what to think, and the constant musical cues to tell us how to feel, and the flashbacks to continually remind us of the stakes. You could make an argument in favor of this, as forthrightly postmodern mediation, but its really just predigestion.

The worst effect of this spelling everything out is the way it boxes in the actors theres not much left for them to communicate, and Bardens relentlessly flat affect, in particular, starts to have diminishing returns. Lawther fares better if only because Jamess cringing neediness is inherently funnier. Ackie, whose face fully registers the tumble of emotions inside Bonnie, dominates the scenes among the three of them.

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Review: Its The End of the World, and Youll Know It - The New York Times

"The darkest things are the hungriest" – AdVantageNEWS.com

Doctor Sleep

Rated R

4 stars

Inner demons, in whatever form they may take addiction, ghosts, vampires are a reliable go-to for what really scares us.

In the case of Doctor Sleep, combining all three doesnt bode well, but makes for a good film.

Writer and director Mike Flanagan (The Haunting of Hill House) was faced with a problem when tackling his newest project how do you make a sequel when the original novel and subsequent film adaptation are so vastly different?

Considering the conundrum, Flanagan chose the only scenario that would work, taking the best elements of Stephen Kings 1977 novel The Shining and combining them with the changes that Stanley Kubrick incorporated into the 1980 film version.

The result is a big-screen attempt at Kings 2013 sequel novel that straddles the fence and courts fans of both versions. Mostly, it works.

Doctor Sleep tells the tale of a grown Danny Torrence (Ewan McGregor), the little boy with the big ability who escaped the evil of the Overlook Hotel as a child. The ensuing years have not been easy ones, as Danny runs from the shadows of his father, the ghosts who continue to pursue him, and the genetic curse of addiction. A young girl (a gifted Kyliegh Curran) with similar psychic gifts (called shining) forces Danny to fight his demons once and for all, personified by a cult of energy vampires known as the True Knot.

While serving as a direct sequel, the films in question are very different The Shining was a straight-up ghost story; Doctor Sleep is a tale of vampire hunters. The Shining was claustrophobic, with only a handful of characters and a boxed-in feeling that grew more magnificently unbearable as the story progressed. Doctor Sleep is much more expansive and has more room to breathe; multiple storylines and characters jump across the country (as well as in and out of the Great Beyond).

As a result, the creeping horror of its predecessor does not permeate Doctor Sleep as effectively. If The Shining is a childs nightmare, then this new film is an inspection and dissection of that nightmare sacrificing terror for the sake of resolution.

That is not to say this film is not scary. The savagery of the True Knot can be downright chilling, and the heartbeat pulsing throughout the entire film tells the viewer that a return to the oppressive Overlook Hotel, and the ghosts that dwell within, is inevitable.

When it comes, the payoff is both satisfactory and frustrating. The sense of nihilism also threatens at times to be too much of a bummer (The whole world is one big hospice with fresh air, Danny says early in the film).

For nostalgias sake, Flanagan revisits Kubricks directing style, along with the familiar soundtrack, without imitating either to the point of redundancy. The acting is less over-the-top, and while McGregor and Curran give fine performances, the real standout is Rebecca Ferguson as the head of the vampiric cabal, Rose the Hat. She truly becomes the films boogeyman unrelenting, vicious, and diabolical.

Doctor Sleep had a myriad of challenges in the transition to the big screen. With a few missteps (mostly in the finale, as is the fate of so much of Kings work), it makes a return to one of Kings most iconic settings a thoroughly enjoyable ride.

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Pixar’s hyper-existential Soul gets its first teaser – The A.V. Club

Soul, otherwise known as the Pixar film featuring a Trent Reznor score, just got its first teaser, which teases an existential journey not unlike that of the studios Inside Out.

Jamie Foxx lends his voice to Joe Gardner, a burgeoning jazz musician who, uh, dies after landing his dream job. In an alternate dimension, he meets another soul named 22 (Tina Fey), whose nihilism strikes uncomfortably against his own passion for art. The two then embark through cosmic realms to try and bring Joe back to the living world. Whats especially interesting is how the film interrogates the idea of suffering for ones art. For anyone who has a profession in the creative arts, its an almost religious obsessiveness you have to have to have success and a career in the arts, Kemp Power, a writer and co-director on the film, told Entertainment Weekly. At any point, no matter how happy you are doing what you do, it feels like that obsessiveness is detrimental to the rest of your life. Gardner, producer Dana Powers continues, has lived his whole life like he was meant to do this one thing [music] to the exclusion of pretty every other thing. Soul, then, is about embracing the breadth of everything life has to offer.

Pete Docter, the mind behind Inside Out, is also responsible for this existential piece, the creator having emerged as Pixars creative leader in the wake of John Lasseters departure. Questlove, Phylicia Rashad, and Daveed Diggs round out the cast, while acclaimed musician Jon Batiste penned the jazz tunes that serve to accent Reznor and Atticus Ross score.

Of the films afterlife animation, Docter told EW, We talked to a lot of folks that represented religious traditions and cultural traditions and [asked], What do you think a soul is? All of them said vaporous and ethereal and non-physical. We were like, Great! How do we do this? Were used to toys, cars, things that are much more substantial and easily referenced. This was a huge challenge, but I gotta say, I think the team really put some cool stuff together thats really indicative of those words but also relatable.

Watch the gorgeous teaser below.

Soul hits theaters on June 19, 2020.

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Pixar's hyper-existential Soul gets its first teaser - The A.V. Club

Sandworm and the GRU’s global intifada – Reason

This episode is a wide-ranging interview with Andy Greenberg, author of Sandworm: A New Era of Cyberwar and the Hunt for the Kremlin's Most Dangerous Hackers. The book contains plenty of original reporting, served up with journalistic flair. It digs deep into some of the most startling and destructive cyberattacks of recent years, from two dangerous attacks on Ukraine's power grid, to the multibillion-dollar NotPetya, and then to a sophisticated but largely failed effort to bring down the Seoul Olympics and pin the blame on North Korea. Apart from sophisticated coding and irresponsibly indiscriminate targeting, all these episodes have one thing in common. They are all the work of Russia's GRU.

Andy persuasively sets out the attribution and then asks what kind of corporate culture supports such adventurism and whether there is a strategic vision behind the GRU's attacks. The interview convinced me at least that the GRU is pursuing a strategy of muscular nihilism"our system doesn't work, but yours too is based on fragile illusions." It's a kind of global cyber intifada, with all the dangers and all the self-defeating tactics of the original intifadas. Don't disagree until you've listened!

Download the 286th Episode (mp3).

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As always, The Cyberlaw Podcast is open to feedback. Be sure to engage with @stewartbaker on Twitter. Send your questions, comments, and suggestions for topics or interviewees to CyberlawPodcast@steptoe.com. Remember: If your suggested guest appears on the show, we will send you a highly coveted Cyberlaw Podcast mug!

The views expressed in this podcast are those of the speakers and do not reflect the opinions of the firm.

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Sandworm and the GRU's global intifada - Reason

Poet and producer James Massiah remembers the times he’s felt most free – Dazed

To celebrate the launch of Burberrys Monogram puffer collection, Dazed partnered with the iconic British brand to spotlight young pioneers breaking boundaries across the globe. We asked four creatives to make a piece of work which responds to the ideas of boundlessness, weightlessness and freedom.View Massiahs zine and the rest of the work in a digital gallery, here.

Usually found rooted behind the decks or deep on the dancefloor at any given night, poet, producer, DJ, and performerJames Massiah is a boundless force in London nightlife, everywhere and nowhere all at once.

This apparently limitless energy has propelled the poet into proclivity, whether hes hosting ongoing NTS broadcast The Potry Show, penning verses in celebration of Prince Charles 70th birthday or performing Optimism 101, a reading of 101 poems orbiting stoicism, materialism, hedonism, and happiness live at the ICA. Last month, the Dazed 100 alum teamed up with director Ian Pons Jewell on aUKMVA-nominated video for his track Natural Born Killers (Ride for Me), a film which sees the poet and a disparate cast of characters crawling through an uninhibitedly overheated dystopian cityscape in an amoral tale of divine retribution or environmental ruin.

Seventh-day Adventist turned amoral egoist, Massiahs is a purposefully self-deterministic philosophy blending moral nihilism with psychological egoism. Freedom, through Massiahs eyes, Looks like Prince, sounds like funk music and feels like being high. It lives in the endless potential of a night out, in altered states and the sense that anything could happen - if you keep your mind open.

Firstly, can you tell us about the work you created for Boundless?

James Massiah: I wrote a series of poems in response to the theme. I recorded them and collaborated with graphic designerPeter Kent to visualise them for a final digital zine.

The poems themselves, what are they about?

James Massiah:Freedom, essentially. Times I've felt free and situations I've been free in. One line talks about having the feeling that no one else exists. I guess relating to feeling free from the expectations and condemnations of others. Another poem describes a party situation, the freedom that is felt in dancing and being in an altered state of consciousness.

I'm a determinist, so I have some interesting perspectives on the notion of freedom. I think I write a lot about freedom from moral or ethical constraints through nihilism and about the freedom to decide what you want for yourself within the constraints offered by your reality through egoism.

I was definitely thinking about nights out, being in a slightly altered state and enjoying the adventures that come at such times, the feeling of freedom from deadline or obligation or routine.

Freedom, through Massiahs eyes, Looks like Prince, sounds like funk music and feels like being high.

What was your first experience of freedom?

James Massiah:Hard to say. I'm sure at the point of birth there was something like that felt and then at many other points in my early childhood. Playing my Nintendo 64, riding my bike, being told I'm not grounded anymore, the end of Sabbath hours, and so many other instances I could imagine.

Give us an insight into the method through which you make your work.

James Massiah:I try not to think too much, opting for impulse and feeling where possible, just to get started having a simple idea in my mind; a word or a picture or a sentence or an idea. Any hard thinking or fact checking or research comes once Ive got that initial burst of inspiration out of the way, it may or may not return, but I try not to burden or inhibit that feeling with too much concern for 'rightness.

Do you have a typical creative process?

James Massiah:It's pretty straightforward for me. Writing down ideas as they come, generally into apps on my phone. I sat down to try and knock out some ideas in a session, and there was some procrastination and doodling. I watched some standup, listen to some rock music, watched some of my favourite series and then got back to it.

I think people underestimate the value of time in these processes though. It's all about being happy with the work, and that may take a day or an hour or a year. So I left it alone and then came back to it, and found myself cutting a bunch of the stuff I'd written and landed on new ideas that I was happy with having had some time to look away and then look back at the poems with fresh eyes.

I love coming up with ideas in the shower or when cycling. Those two modes really seem to help generating ideas.

Finally, what you are looking forward to seeing next from Riccardo Tisci at Burberry?

James Massiah:I've always been a fan of the trench coat, I'm excited to see how it can be reimagined for the future.

Click here to be transported into Boundless, a weightless digital realm

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Poet and producer James Massiah remembers the times he's felt most free - Dazed

Earl Sweatshirt’s Eccentricity on Full Display in EAST – The Heights – The Heights

The enigmatic rapper Earl Sweatshirt solidified his reputation as one of the industrys most innovative talents with the release a strange, disorderly music video for the song EAST on Friday. The video follows the recent arrival of Earls EP Feet of Clay. The EP builds on the discordant, choppy sampling techniques used on his previous project released this year, Some Rap Songs, while Earls lyrics reflect the despondency found on his 2015 album I Dont Like Shit, I Dont Go Outside.

The music video manifests the songs choppy production aesthetic through a visually compelling yet bizarre piece of art that appears fractured and unrelated to the song on first viewing yet ultimately succeeds in reflecting Earls struggling mental state.

The video opens with Earl standing on a beach in slides, Corona in hand, smoking a cigarette and hanging out with friends. A superimposed photograph of the moon floats about the screen, and another smaller video of a man running in a parking garage flipping off the camera pops up in the upper right-hand corner. There is not only a lack of cohesion at this point in the video, but a clearly intentional decision by Earl to offer something utterly original and unpredictable to the viewer. The lyrics of EAST deal with alcoholism and his struggles in coping with the passing of his father. He seems to be forgoing representing the plotline of the song in favor of depicting his own scattered and more abstract feelings of loss of direction and meaning.

Shot on an iPhone, the video reflects the independent ethos of Earls music along with his musics lo-fi production quality. Due to his sparse production style, his lyrics have space to operate outside the constraints of more polished instrumentation. Earl is serious about the content and wordplay of his lyrics, despite how outlandish his personality and nonchalant style may seem.

EAST is benefited by the frenetic, carnival-style accordion loop that sounds almost like the flying monkeys from the Wizard of Oz are about to appear at any moment. And with the amount of strange images popping up in the video, it was almost disappointing when they didnt. The video ends with Earl walking off camera, leaving viewers just as unsettled and confused as they were at the start and ultimately wondering, What was the point?

This resigned nihilism pervades Earls work and has almost caused him to quit rapping multiple times. Most notably, he talked about his feelings of disillusionment with the rap industry after a return from a center for troubled youth in Samoa on his 2013 album Doris. On the song Chum, he sadly confesses, Been back a week and already feel like calling it quits. Although Earl is certainly still struggling with finding meaning in the commercial rap industry, in the video for EAST he shows that he is channeling these emotions into compelling, utterly original art.

Featured Image by Warner Records

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Earl Sweatshirt's Eccentricity on Full Display in EAST - The Heights - The Heights

Division Biological Engineer Recognized for Research in Nanotechnology – University of Arkansas Newswire

Fred Miller, Division of Agriculture

Jin-Woo Kim uses an atomic force microscope to examine the structures of nano materials.

FAYETTEVILLE, Ark. Really tiny things are a big deal to Jin-Woo Kim. For his work in nanotechnology, he has been named the 2019 Arkansas Biosciences Institute Established Investigator of the Year.

Kim, a professor of biological and agricultural engineering for the University of Arkansas System Division of Agriculture and the University of Arkansas College of Engineering, has spent years developing methods for turning nanoparticles into practical tools for medical, agricultural and manufacturing uses.

Nanoparticles are between 1 and 100 nanometers long, a nanometer being equal to one billionth of a meter.

Kim's research, funded by grants from the National Science Foundation and the National Institute of Health, combines multiple nanoscale materials into single, multifunctional structures with defined physical, chemical or biological characteristics that hold promise for advanced materials and devices. Engineering the shape, size and material compositions influences the useful properties of those materials.

Such materials offer valuable applications for biosensing, biosecurity or nanomedicine, as well as advanced uses in optoelectronics and nanophotonics, Kim said.

"The potential applications of these technologies is wide open," Kim said.

To produce these materials, Kim has been developing nano-building-block technology to guide self-assembly of nanoparticles into specific shapes for specific purposes. He calls it nBlock technology, and it induces nanoparticles to arrange themselves into designed structures.

Now, he is working to expand nBlock technology into more general techniques that can be applied to many different manufacturing designs. He aims to develop a nanotoolbox of assembly methods that are not limited to a single, specific material, but that can be used to produce an unlimited number of different materials.

One of the challenges, Kim said, is scaling up production for manufacturing bulk materials. Self-assembly is a powerful strategy, he said, but the accurate, scalable and high-rate assembly of nanoparticles into specifically designed shapes and sizes is difficult to accomplish.

"Nanotoolbox technology addresses the urgent need for functional, reliable and scalable techniques to fabricate customizable nanostructures for a wide range of uses," Kim said.

In another project, funded by NSF's Center for Advanced Surface Engineering, Kim is developing efficient and sustainable technologies to produce cellulosic nanomaterials from woody biomass.

The raw material is essentially waste from timber industries, Kim said. "A report from the Department of Energy indicates that U.S. forestry operations generate 97 million dry tons of waste annually," he said.

According to the U.S. Department of Agriculture, Arkansas produces 4 million dry tons of waste each year.

"If that abundant and cheap raw material can be sustainably and economically converted into value-added products," Kim said, "it could provide a significant boost to the state's economy."

To investigate the potential of waste biomass for nanomaterial uses, Kim is investigating the impact of genetic and environmental influences on the quantity and quality of nanocellulose. These factors can help identify the most suitable cellulose resources in Arkansas for nanoparticle production, he said.

Kim is combining multiple production processes to identify the most efficient and sustainable methods to fabricate nanocellulose.

In his study of manufacturing processes, Kim said he is targeting both low-cost, high-volume and high-cost, low-volume markets by developing processes with options to synthesize cellulose nanomaterials to different degrees of purity.

Materials with high purity are costly to produce and are suitable for medical or electronic industries. Such products might include drug delivery systems or medical diagnosis agents, smart fabrics, sensing or imaging nanomaterials and other high-end technical uses.

Nanomaterials produced with lower purity at lower cost are suitable for such products as packing materials, filters, some construction materials, microbeads and other uses where high purity is not required.

"USDA estimates that the market size of nanocellulose-enabled products will reach 35 million metric tons per year by 2050," Kim said.

"Developing a viable way to fabricate value-added products from cellulosic nanomaterials could propel Arkansas into a new era of forest bio-based production industries," Kim said. "There's high potential to advance the state's manufacturing, agriculture, forestry and healthcare industries."

To learn more about Division of Agriculture research, visit the Arkansas Agricultural Experiment Station website:https://aaes.uark.edu. Follow us on Twitter at@ArkAgResearchand Instagram atArkAgResearch.

About the Division of Agriculture:The University of Arkansas System Division of Agriculture's mission is to strengthen agriculture, communities, and families by connecting trusted research to the adoption of best practices. Through the Agricultural Experiment Station and the Cooperative Extension Service, the Division of Agriculture conducts research and extension work within the nation's historic land grant education system.

The Division of Agriculture is one of 20 entities within the University of Arkansas System. It has offices in all 75 counties in Arkansas and faculty on five system campuses.

The University of Arkansas System Division of Agriculture offers all its Extension and Research programs to all eligible persons without regard to race, color, sex, gender identity, sexual orientation, national origin, religion, age, disability, marital or veteran status, genetic information, or any other legally protected status, and is an Affirmative Action/Equal Opportunity Employer.

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Division Biological Engineer Recognized for Research in Nanotechnology - University of Arkansas Newswire

IFFCO introduces Indias first nanotechnology-based products for on-field trials – Livemint

New Delhi: The Indian Farmers Fertiliser Cooperative Limited (IFFCO), worlds largest fertiliser cooperative, on Sunday announced the introduction of its nanotechnology-based product range by introducing Nano Nitrogen, Nano Zinc, Nano Copper for on-field trials at an event held at its Kalol unit in Gujarat.

These products have been researched and developed indigenously at the IFFCO Nano Biotechnology Research Centre (NBRC), an advanced research and development centre based at Kalol Unit. These nanostructured formulations effectively deliver nutrients to the plants. Other benefits of these Nano-products include reduction in the requirement of conventional chemical fertilizer by 50%; upto 15-30% increase in crop production; improvement in soil health; reduction in the emission of greenhouse gases.

Speaking at the event in the introductory speech U.S. Awasthi, MD, IFFCO said," In the first phase of the launch these products will be tested on farms under controlled conditions with support from ICAR/KVK. For this phase IFFCO has introduced three types of the nano-products. The first is IFFCO NANO NITROGEN which is developed as an alternative to Urea. If used properly, this product has the potential to cut the requirement of Urea by 50%. The second is IFFCO NANO ZINC which is developed as an alternative to the currently used Zinc fertilisers. Only 10 gm of this product would be sufficient for a hectare of land and would bring the requirement of NPK fertilizer down by 50%. The third product is IFFCO NANO COPPER which provides both nutrition and protection to the plant. It boosts the plants immunity against harmful pathogens and helps increase the activity of plant growth hormone and improves overall plant growth and development."

Speaking at the event, Sadananda Gowda, Union Minister of Chemicals & Fertilizers praised IFFCO for its efforts and said This step will certainly complement to the vision of our PM Shri Narendra Modiji for doubling the farmers income by 2022."

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IFFCO introduces Indias first nanotechnology-based products for on-field trials - Livemint

Engineers Create Tiny ‘Artificial Sunflowers’ That Bend Towards The Light – ScienceAlert

When it comes to squeezing maximum amounts of energy out of the daylight hours, plants have a head start thanks to evolution.

Now, engineers have designed solar panels that mimic the sunflower's sun-chasing talent, through clever use of nanotechnology.

By moulding temperature-sensitive materials into thin, supportive structures, scientists have come up with tiny 'stems' that bend towards a bright light source, providing a moving platform that could dramatically improve the efficiency of a range of solar technologies.

Researchers from the University of California Los Angeles and Arizona State University refer to their system as a sunflower-like biomimetic omnidirectional tracker. Or 'SunBOT', if you like your acronyms.

In biological terms, any general movement in response to specific changes in the environment is described as a nastic behaviour. Flowers that open at dawn and close at dusk are a good example of this.

Chemists have had little trouble making synthetic nastic materials and structures that open and close, or bend and twist in response to changes in light intensity or fluctuating temperatures.

But nature has another, slightly more complicated behaviour that directs the movements of organisms towards good things and away from threats.

Thesetropic behaviours are what we see when sunflowers tilt their flowers to face the Sun, warming their reproductive bits in order to attract pollinators.

Sun-chasing actions, or heliotropism, would be mighty handy for things like photovoltaics, which are most efficient when bathed in a dense glow of radiation hitting their surface straight-on, rather than from a more shallow angle.

In practical terms, compared to rays from an overhead illumination source, light coming in at an angle of around 75 degrees carries as much as 75 percent less energy.

To solve this problem of oblique-incidence energy-density loss, the research team looked to gels and polymers that respond predictably to light or heat.

A handful of different materials were selected as candidates worth closer investigation, including a hydrogel containing gold nanoparticles, a tangle of light-sensitive polymers, and a type of liquid crystalline elastomer embedded with a light-absorbing dye.

Each arrangement was shaped into a millimetre-wide thread several centimetres in length.When targeted by a laser, the tiny artificial stalks responded rapidly to the light's warmth, shrinking on one side and expanding on the other to cause the thread to kink and lean towards the laser.

To put their synthetic sunflowers to the test, the researchers assembled an array of SunBOTs and submerged them in water, letting them sit right at the water-air boundary.

To detect the harvesting capabilities of their invention, the team then determined how much light was converted to heat by measuring the water vapour their setup generated.

Changes in the amount of vapour indicated that the SunBOTs were up to four times better at harvesting energy at steep angles than a boring old flat, static surface.

By demonstrating that a variety of materials could serve as a synthetic tropic material, the researchers argue their devices could potentially be a solution for just about any system that experiences a loss of efficiency due to a moving energy source.

For example, lawns of these miniature sun-worshippers could theoretically be used to tilt just about any solar process towards the light, from itty-bitty solar cells to evaporation devices that can purify water.

According to the SunBOTs' designers, the sky (if not beyond!) seems to be the limit for this kind of technology.

"This work may be useful for enhanced solar harvesters, adaptive signal receivers, smart windows, self-contained robotics, solar sails for spaceships, guided surgery, self-regulating optical devices, and intelligent energy generation (for example, solar cells and biofuels), as well as energetic emission detection and tracking with telescopes, radars and hydrophones," they write in their report.

Even if just a handful of those predictions eventuates into real-world use, the future of synthetic tropic materials is certainly looking brighter.

This research was published in Nature Nanotechnology.

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Engineers Create Tiny 'Artificial Sunflowers' That Bend Towards The Light - ScienceAlert

Glowing with the flow – Harvard School of Engineering and Applied Sciences

In the battle against heart disease, more than 400,000 coronary artery bypass grafting surgeries are performed in the U.S. each year.

While veins from a patients leg are often used in the surgical procedure, tissue-engineered vascular grafts (TEVG), which are grown outside the body using a patients endothelial cells, are proving to be an effective and increasingly popular technique.

The most common reasons for TEVG failure are conditions like blood clots, narrowing of the blood vessels, and atherosclerosis. But what if these grafts could be engineered to detect and even prevent those ailments from occurring?

A team of Harvard John A. Paulson School of Engineering and Applied Sciences students set out to answer that question for their project in this years International Genetically Engineered Machine Competition. The project, dubbed FlowGlo, seeks to use receptors that exist within the walls of human blood vessels to detect shear stress, a warning sign that a blood vessel may be narrowing.

Shear stress is important to detect because it is a marker of a lot of different cardiovascular diseases. When there is narrowing of a blood vessel due to a blood clot, shear stress jumps exponentially, maybe up to 10 times its normal level, said Teagan Stedman, S.B. 22, a bioengineering concentrator. Our idea is to link the activation of these receptors due to some level of shear stress to a modular response.

Shear stress is a function of viscosity and how rapidly different layers of fluid are flowing over each other through a blood vessel. Because the walls of the vessel must move and roll with the strain of blood flow, receptors naturally activate at different levels of shear stress.

For instance, when shear stress rises above 4 Pascals, channels open in one specific protein receptor, Piezo1, and calcium ions enter the cell, signaling the activation. The students engineered Piezo 1 and two other protein receptors to present different colored fluorescent proteins when that activation occurs.

Down the road, instead of using a fluorescent protein, you could possibly swap it out so the cells secrete some kind of clot busting protein to break up the clot and treat it on site, said Patrick Dickinson, A.B. 22, an applied math concentrator. Current clot-busting medication is delivered through an IV, and it is system-wide and much less targeted, so there are greater risks for side effects. We think this could be a more targeted treatment in the long run.

As part of their project, the team gathered feedback from Elena Aikawa, Professor of Medicine at the Harvard Medical School and Director of the Vascular Biology Program at Brigham and Womens Hospital, who studies tissue-engineered vascular grafts. They also conducted a survey to better understand public perception of genetic engineering ethics, since their technique would require engineered cells to be implanted in the human body.

As they gathered qualitative data, they worked long hours in the lab on intricate experiments. Since beginning the project this summer, the teammates overcame many challenges caused by the difficulty of cloning cells. Relying on the support of their mentor, Timothy Chang, a postdoctoral fellow in the lab of Pamela Silver at the Harvard Medical School, they brainstormed, troubleshot, and learned volumes about synthetic biology along the way.

I learned that biology is messy, Dickinson said. In a lab setting, there is a lot that is hard to predict. We certainly encountered a lot of frustration and stress along the way, but it was a good window into what research really is.

Now that the competition has concluded, the teams work will be included in the iGEM Registry of Standard Biological Parts, a repository of genetic parts that can be mixed and matched to build synthetic biology devices and systems.

For Rahel Imru, it is gratifying to know that future iGEM teams and research groups from around the world could someday build off the research she and her peers have done.

While the weeks leading up to the competition were a whirlwind, the experience was well worth the effort, said Imru, A.B. 21, a biomedical engineering concentrator.

This was my first lab experience, so I definitely learned a lot, she said. I look back and see how much weve grown. Maybe we didnt get all the data and results we wanted to by the end, but for the size of our team and the time that we had, seeing what we are able to accomplish is especially rewarding.

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Glowing with the flow - Harvard School of Engineering and Applied Sciences

Five Reasons Why Its Never Too Late To Start A Business – Forbes

PeakPx

Mark Zuckerberg founded Facebook when he was 19 years old. By 25, his company was valued at over $5 billion. At 28, he took Facebook public. Now, at the age of 35, he is among the top 10 richest people in the world.

When we think of entrepreneurs, we tend to think of the Mark Zuckerbergs of the world youthful visionaries who disrupt traditional businesses with a new and better ways of doing things.

New research, however, challenges the view that youth is advantageous to entrepreneurial success. Perhaps a better entrepreneurial archetype is that of Herbert Boyer. Boyer founded Genentech at the age of 40 based on his breakthrough discoveries in genetic engineering. Or, consider the story of David Duffield. Duffield founded Workday, a financial and human capital management software company, in his 60s, after spending a career in application software. Now, Workday has a market capitalization of over $40 billion.

The data is increasingly showing that its never too late to start a business. Below are five research-backed reasons why entrepreneurial success may come quickest to those who wait.

1) The stereotype of the very young and very successful entrepreneur is exactly that a stereotype.

It turns out that the media may be the biggest culprit in perpetuating the belief that entrepreneurship is a young mans game. For example, the website TechCrunch gives annual awards to the most compelling startups, internet and technology innovations of the year. The average age of award recipients from 2008 to 2016 was 31. Inc. magazine and Entrepreneur magazine also publish lists of entrepreneurs to watch. In 2015, the average age of entrepreneurs who made this list was 29. Compare that to the average age of a typical startup founder (42) to see the discrepancy.

2) Not only are older entrepreneurs more common, they are more successful.

42 is the average founder age of all S-corporations, C-corporations, and Partnerships that registered in the United States between 2007 and 2014. Examining the performance of these companies reveals yet another trend: companies with older founders tend to outperform companies with younger founders. Looking at the top 1% of startups (in terms of company performance), the average founder age increases to 43. Looking at the top 0.1%, the founder age increases even more, to 45. Moreover, the average age of startup founders who achieved a successful exit (as defined by an acquisition or an IPO) is 47.

3) Entrepreneurs working in major entrepreneurial hubs are no younger than other entrepreneurs.

Another misconception is that startup founders practicing in the hottest entrepreneurial hubs think Silicon Valley and New York City are younger than in other areas of the country. Again, the data does not show this to be the case. The average age of entrepreneurs in California, Massachusetts, and Silicon Valley is also 42. And, in New York City, the average entrepreneurial age is only one year younger than average (41).

4) The average age of new entrepreneurs entering the market over the past decade has increased.

Given the rise of technology and technology-related entrepreneurship, one might guess that the average entrepreneurial age has fallen in recent decades. Again, the data suggest the opposite. The average founder age has risen from 41.8 in 2007 to 42.5 in 2014.

5) Certain fields attract entrepreneurs that are older than average.

Not surprisingly, there is truth to the idea that technology is a young mans game. However, the age spread is not as wide as one might think. For instance, startup founders operating in the software publishing industry are, on average, 40 years old (two years younger than the overall average). That said, there are other fields that attract older entrepreneurs. For example, the average age of founders in the pipeline transportation of natural gas, basic chemical manufacturing, and paint, coating, and adhesive manufacturing industries are 51, 48, and 48, respectively. Startup founders operating in oil and gas extraction and engine, turbine, and power transmission equipment manufacturing are also significantly older than other types of entrepreneurs.

Conclusion. The novelist George Eliot famously said, Its never too late to be what you might have been. This is sage advice for all aspects of life, but it might be especially relevant in the case of entrepreneurship.

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Five Reasons Why Its Never Too Late To Start A Business - Forbes

Keep Bioethics out of Elementary and High Schools – National Review

(Mike Blake/Reuters)

Bioethicist Jacob M. Appel wants the bioethics movement to educate your children about the policy and personal conundrums that involve medical care and health public policy. He claims that most of us give little thought to issues that may arise, such as end-of-life care and prenatal screening. Then, when an issue arises, people are unprepared to make wise and informed decisions. From, The Silent Crisis of Bioethics Illiteracy, published in Scientific American:

Change will only occur when bioethics is broadly incorporated into school curricula [at an early age] and when our nations thought leaders begin to place emphasis on the importance of reflecting meaningfully in advance upon these issues

Often merely recognizing such issues in advance is winning the greater part of the battle. Just as we teach calculus and poetry while recognizing that most students are unlikely to become mathematicians or bards, bioethics education offers a versatile skill set that can be applied to issues well outside the scientific arena. At present, bioethics is taught sporadically at various levels, but not with frequency, and even obtaining comprehensive data on its prevalence is daunting.

Is this really an appropriate field for children? Consider the issues with which bioethics grapples and whether elementary-, middle-, and high-school children have the maturity to grapple with them in a meaningful and deliberative way (not to mention, the acute potential that teachers will push their students in particular ideological directions):

Even if some students are mature enough to grapple with these issues thoughtfully, the next problem is that bioethics is extremely contentious and wholly subjective. Its not science, but focuses on questions of philosophy, morality, ideology, religion, etc.. Moreover, there is a dominant point-of-view among the most prominent voices in the field e.g., those who teach at leading universities and would presumably be tasked with writing the educational texts. These perspectives would unquestionably often stand in opposition to the moral values taught young students by their parents.

Appel is typical of the genus (if you will). He has called for paying women who plan to abort to gestate longer in their pregnancy so that more dead fetuses will be available sufficiently developed to be harvested for organs and used in experiments. He advocates mandatory termination of care for patients who are diagnosed as persistently unconscious to save resources for what he considers more important uses. He has also supported assisted suicide for the mentally ill.

Appels perspectives are not unique in bioethics. The movement went semi-berserk when President George W. Bush appointed the conservative bioethicist Leon Kass to head the Presidents Council on Bioethics one even called him an assassin for opposing human cloning research as many worked overtime to discredit the Councils work in the media.

Indeed, activists without a modifier like Catholic or pro-life before the term bioethicistare overwhelmingly very liberal politically and intensely secular in their approach. Most support an almost unlimited right to abortion, the legalization of assisted suicide, genetic engineering (once safe), and accept distinguishing between human beings and persons, that is, they deny universal human equality.

Some wish to repeal the dead donor rule that requires organ donors to be dead before their body parts are extracted an idea that admittedly remains somewhat controversial in the field. Most mainstream bioethicists deny the sanctity of human life and many think that an animal with a greater cognitive capacity has greater value than a human being with lower cognition. Add in the sectors general utilitarianish approach to health-care issues, such as supporting rationing, and the potential for propagandizing becomes clear.

With such opinions, often passionately held, how long would it be before early bioethics education devolved into rank proselytizing? But Wesley, Appel might say. the classes would be objective! Every side would be given equal and a respectful and accurate presentation.

Sure. If you believe that, you must think current sex education curricula and high school classes in social justice present all sides of those issues dispassionately and without attempt to persuade the students to particular points of view and cultural perspectives.

I have a deal for Appel: In-depth courses in bioethics should not be taught before college unless I get to write the textbooks! I promise to be objective and fairly present all sides. Honest!

Do you think he and his mainstream colleagues would approve of that deal?

Neither do I. And we shouldnt go along with his idea for the very same reason.

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Keep Bioethics out of Elementary and High Schools - National Review

CSU ground zero this week for biodefense meeting on threats to livestock, crops and human life – The Denver Channel

FORT COLLINS, Colo. -- China is in the midst of one of the largest outbreaks of pork disease in history, more than half-a-million pigs wiped off the map by a swine fever so insidious it's been likened to Ebola.

May would be quick to look at something like this and say "that's terrible, but it's not like it's going to happen here in the U.S., certainly not Colorado."

But, experts insist that not only is it possible, it could one day be intentional.

There are terrorists who online are looking for biological weapons," said Asha George, executive director of the U.S. Commission on Biodefense.

Thats why George and others with the Bipartisan Commission on Biodefense are visiting Colorado State University in Fort Collins this week. They say theres a real threat that it could easily happen here.

"Right now, we have an African swine flu problem in China that really isn't getting the attention it deserves, said former U.S. Senator Tom Daschle, who sits on the commission. But, it could easily spread to American livestock, as well."

The bi-partisan commission says it goes beyond naturally-occurring outbreaks. There are intentional threats, as well.

"The state department suspects countries like Russia, China, Iraq, Iran, North Korea and even Syria - what theyre trying to do is pursue an advantage using asymmetric warfare," George said.

And terrorist groups possibly pose the most imminent threat.

"Its not difficult to contemplate a situation where instead of airplanes into buildings it's pathogens against humans, pathogens against livestock or crops, said Ken Wainstein, former homeland security advisor and commission member. And it could have a devastating impact."

The commission says the impact to human life and the economy would be catastrophic.

"And because things move around this planet so quickly, we can have a very serious threat at our doors within 24 hours," said Alan Rudolph, vice president of research at Colorado State University.

The decision to hold the forum at CSU was no coincidence. U.S. leaders say the university is leading the charge in biodefense.

"This and Kansas State University are the only two places weve held these discussions, Daschle said. This is where people and resources and real focus and priority lies."

The team says the U.S. must develop real countermeasures like antibiotics and vaccines to isolate threats that could cause incalculable destruction.

"In the absence of those countermeasures, we're screwed," George said.

"Were here sounding the alarm that maybe in the past and present, we're not taking the biothreat seriously enough," Wainstein said.

The commission started as a blue-ribbon study panel and eventually evolved. It delivered its first report to Congress in November 2015 and continues to make strides in biodefense.

As for whats happening in China, George said the economic impact is global. "Sixty percent of all the pigs are either already infected or they're just killing them," she said. Thats a huge, huge hit.

The U.S. battled an Avian influenza outbreak in chickens and poultry a few years ago.

When you start adding things like synthetic biology and genetic engineering, suddenly we have this massive problem that we need to deal with," George said. We cant ignore outbreaks and epidemics until they end up here and then suddenly everybody's freaking out.

The biological threat against this nation is real, Wainstein said. It's real as it relates to humans, as it relates to animals and as it relates to crops.

The commission says bringing the conversation to universities like CSU helps to open-up the conversation, spark new ideas on how to prevent bio-threats and helps the nation understand what they're role we each play.

Colorado State is right in the middle for good planning for that experience, Daschle said. With the resources and leadership to understand and study animal health.

The threat is exacerbated by lack of good countermeasures like antibiotics and their overuse that has resulted in bacteria becoming immune or resistant, Rudolph said. And these universities are now essentially ecosystems of innovation.

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CSU ground zero this week for biodefense meeting on threats to livestock, crops and human life - The Denver Channel

The Slowness of Literature and the Shadow of Knowledge – The New Yorker

The following was adapted from a speech delivered at the Frankfurt Book Fair in October.

Frankfurt, the financial hub of Europe, is home to one of the biggest stock exchanges in the world, where everything is about quick deals and quick money. It is home, too, to a book fair, which also happens to be one of the biggest in the world, and where everything, likewise, is about buying and selling, though the trade is in booksalbeit only the newest ones, which appear in their hundreds of thousands each year. On the occasion of the fair, it is worth thinking about one of literatures most important characteristics: its slowness.

Im not thinking of how long it takes to read a book but of how long its effects can be felt, and of the strange phenomenon that even literature written in other times, on the basis of assumptions radically different to our own and, occasionally, hugely alien to us, can continue to speak to usand, not only that, but can tell us something about who we are, something that we would not have seen otherwise, or would have seen differently.

Some sixty years before the birth of Christ, Lucretius wrote his only known work, On the Nature of Things, a didactic poem about how the world is made of atoms. The atomic reality that Lucretius describes is not an isolated phenomenonit is not a separate realm of electrons and nuclei, electromagnetic fields, particles and waves. In Lucretius poem, the atomic dimension exists side by side with the world as we see it every day, with its grassy plains and rivers, its bridges and buildings, its cows and goats, its birds and its sky. Lucretius knew that the two domains are sides of the same coin, that the one does not exist without the other. There is little doubt in my mind that the world today would look different if the progress of science had been anchored in our human reality instead of losing sight of it, for in that recognition lies an obligation and an unceasing correction: we are no greater than the forestwe are no greater even than the tree. And we are made of the same constituents.

Lucretius poem was long forgotten. But when, eventually, it was rediscovered, in the early fifteenth century, it marked a significant prelude to the dawning Renaissance, and, not only may it still be read todayit continues to speak to us, telling us things we have forgotten, or things we perhaps never truly understood.

Literature works slowly not just in history but also in the individual reader. I remember the first time I read the Danish poet Inger Christensen and, in particular, her long poem alphabet. This was in the mid-nineties, some twenty-five years ago now. alphabet is a list of things occurring in the world; in Susanna Nieds English translation, it begins like this:

apricot trees exist, apricot trees existbracken exists; and blackberries, blackberries;bromine exists; and hydrogen, hydrogen

cicadas exist; chicory, chromium,citrus trees; cicadas exist;cicadas, cedars, cypresses, the cerebellum

doves exist, dreamers, and dolls;killers exist, and doves, and doves;haze, dioxin, and days; daysexist, days and death; and poemsexist; poems, days, death

At the time, twenty-five years ago, I found this poem beautifulthere came from it a very special kind of existential glow. But it did no more than flame up for me in the moment. Then, a few years ago, it resurfaced in my mind. I dont know why. But I read it again, and it had taken on new meaning. Firstly, I sensed a grief in its evocation of objects, animals and plants, as if somehow a shadow were now hanging over them. It could have been the knowledge that at some point we are to die and leave them behind, but it could also have been the knowledge that they might die and leave us behind. There are many animal species we no longer can take for granted.

Secondly, I was now aware of how the poem formally intertwines culture and nature. The entities listed in the poem do not occur randomly but are structured, in two waysalphabetically, and according to the principles of the so-called Fibonacci sequence in mathematics, whereby each number is the sum of the two preceding ones: 1, 1, 2, 3, 5, 8, 13, 21, and so on. This pattern occurs throughout the natural world, in the genealogy of bees, in the branching of trees and flowers, in petal numbers, pine cones, pineapples, and sunflowers. This underlying structure, to which nature itself is at once oblivious and obedient, belongs quite as much to mysticism as to mathematics. In the words that the poem isolates, calling forth their singular entities and phenomena, the world becomes at once familiar and alien to us, at once sensuous and abstract, comprehensible and incomprehensible at the same time.

Christensen is clearly related to Lucretius. The word that Lucretius used for atom is the same word he used for letter of the alphabet. This was also true of the first of the Greeks to write of the atom: they, too, employed the term for letter of the alphabet. Lucretius repeatedly compares atoms with letters; just as the same few letters may be combined in endless ways to express everything between heaven and earth, the same few atoms may be combined to create heaven and earth and everything in between.

Science and literature alike are readers of the world. And, sooner or later, both lead us to the unreadable, the boundary at which the unintelligible begins. In one of her essays, Inger Christensen writes that that boundary, between intelligible and unintelligible, exists within us; science, she writes, conducts the conversation between readability and unreadability using terms such as chaos theory, fractals, and superstrings only because to use the word God would seem overbearing.

Everything exists side by side. Atoms, letters of the alphabet, literature, science, the world. And insight and destruction.

The world in whose midst we now stand, with its skyscrapers and cars, its airports and its banks, also emerged slowly, and, if we were to pinpoint its beginnings, the great upheavals that occurred in Europe around the time of the rediscovery of Lucretius book would be key. The Italian scholar and humanist Poggio Bracciolini unearthed On the Nature of Things in January, 1417. He most likely found the book, perhaps the only copy then in existence, in the German monastery of Fulda, no more than a hundred kilometres from Frankfurt. Some thirty years later, around 1450, Gutenberg developed the printing press. That, too, happened in this region, in Mainz, only forty kilometres from here. Also around this time, the legend of Faust, the learned vagabond who sold his soul to the Devil, took shape in Germany. The roots of the Frankfurt Book Fair go back to that same periodthe first one took place in 1454.

It remains unclear quite how the legend of Faust emerged, but history does make mention of a real Johann Faust, who matches the description, and who is said to have been born twenty-six years after that first book fair, in 1480, at a place called Knittlingen, not a hundred and fifty kilometres from Frankfurt. He is described as a learned charlatan purporting to be skilled in magic, and he appears to have wandered the region with sojourns at its various universities. We know he was in Wrzburg in 1506, a hundred and ten kilometres from Frankfurt, and in Kreuznach in 1507, a hundred and thirty kilometres from here. And we know, too, that in 1509 he was awarded a degree from the University of Heidelberg, only ninety kilometres from here. So we can by no means rule out that Faust, too, attended the book fair at Frankfurt.

Another historical candidate is a certain Johann Fust, who lived from 1400 until 1466. Fust was a goldsmith and a business partner of Gutenbergs, in Mainz, forty kilometres from Frankfurt.

But what about the Devil? Where was he?

If nothing else, we know that he was once in Wartburg, two hundred kilometres from here. In the early fifteen-twenties, the Devil was seen there by a monk who, late one night, sat immersed in his work, translating the Bible into German. The monk called himse
lf Junker Jrg, though his real name was Martin Luther, and he was so enraged at the Devil for interrupting him in his labors that he hurled an ink pot at him.

Here then, in this strangely hybrid world of superstition and rational thought, magic and science, witch burnings and book printing, the reality we now inhabit was founded. The invention of the printing press made it possible to accumulate and disseminate knowledge on a scale hitherto unseen. Here began the slow separation of science from religion which so radically altered our view of the world and ourselves that today we can scarcely believe that anything was ever any different.

So what was the Devil doing there, in the foundation of what was to become the world as we know it?

It can be held, of course, that the Faust legend is a Protestant formation narrative: the tale emerged at the time of the Reformation, and Fausts sin is not necessarily that he seeks knowledge but that he does so while removing himself from God. And, to Goethe, who also hailed from Frankfurt, Fausts sin was secular: he sought knowledge without knowing love.

But its hard to ignore the thought that where man strives for knowledge, the Devil will never be far away. It was the Devil, in the shape of a serpent, who enticed Eve to eat the fruit from the tree of knowledge, leading to man being banished from Paradise, and it was the Devil whom Faust evoked in his efforts to penetrate the secrets of nature.

With all our technological advances, from the printing press to the airplane and the nuclear-power station, there seems to follow a shadow, unseen and yet perceptible, for the consequences of these advances manifest themselves before our eyes. Karl Benz, who, in 1885, built the first motorcar in a workshop in Mannheim, only eighty kilometres from Frankfurt, could hardly have realized that, in the future, his machinewhich would join places and people together, opening cultures to each other and increasing the radius of human life so considerablywould claim the lives of one and a quarter million people each year, in car crashes. Nor could he have known that carbon-dioxide emissions from cars would be a cause of global warming, rising sea levels, burning forests, growing desert areas, and the extinction of animal species.

This phenomenon, whereby the well-intended action of the one spirals into uncontrollable evil when the one becomes the many, is referred to by French philosopher Michel Serres as the original sin. Diabolically, although each of us may wish only good, by our collective deeds we end up committing evil.

The Devil is associated with transgression; he is its very figure. And, since the endeavor to wrestle from nature its innermost secrets is a transgression, Faust must accordingly seek the Devils help.

The Devil exists to us because transgression puts us at peril. The insight is as old as culture itself. And Faust was as relevant in the fifteen-hundreds as he was in the eighteen-hundreds, when Goethe wrote about him, and in the nineteen-forties, when Thomas Mann wrote about him in his novel Doctor Faustus. Doctor Faustus begins with a scene which, when I read it for the first time, at the age of nineteen, etched itself into my memory. Two young lads, with the oddly sounding names Serenus Zeitblom and Adrian Leverkhn, grow up together in the depths of Germany at the end of the nineteenth century, and, at the beginning of the novel, Adrians father performs for them some scientific demonstrations. These concern how dead, inanimate matter may behave as if it were alive. Adrian, who will later sell his soul to the Devil, is amused by his fathers reverence of the mysteries of nature and shakes with laughter, whereas Serenus is aghast.

I dont know why that scene etched itself into my memory at the time, when I was nineteen, but I do know why I keep coming back to it: there, in that room, the living and the dead, the authentic and the inauthentic, alchemy and science, the Devil and modernity, all came together. And none of the elements present in that room has become any less significant to us since Mann brought them together, in the nineteen-forties; rather, they have become consolidated, for, since then, the atom has been split, and we have isolated and analyzed DNA, and now ventured into genetic engineering. The scientific opportunities this presents are hugeplants may be improved, food production increased, organs may be grown, even new life created. Man, we could say, has at last become like God. But, in one ancient text, nearly three thousand years old, we can read about what happened to someone else who wanted to become like God:

For thou hast said in thine heartI will ascend into heaven,I will exalt my throne above the stars of God:I will sit also upon the mount of the congregation, in the sides of the north:I will ascend above the heights of the clouds;I will be like the most High.Yet thou shalt be brought down to hell,to the sides of the pit.

Or, to use the words of perhaps the greatest German poet of them all, Friedrich Hlderlin, born a hundred and sixty kilometres from Frankfurt: Nothing makes with greater certainty the earth into a hell, than mans wanting to make it his heaven. Yet the mutual proximity of insight and destruction tells us nothing of the sequence of these things, and the same Hlderlin wrote something else, which is equally true, in one of his unworldly and exquisite poems: But where the danger is, also grows the saving power.

Translated from the Norwegian by Martin Aitken.

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The Slowness of Literature and the Shadow of Knowledge - The New Yorker

Why making healthy babies in space should be quite the adventure – Genetic Literacy Project

Earth is great and all, but with climate change and the extremely highly likely reemergence of dinosaursdue to genetic engineering, we might need to consider inhabiting other planets. Sending out a pioneering colony of carefully-selected humansis today science fiction but, someday, it might save our species.And, if we ever actually docolonize space, were going to need to have babies up there, which might turn out to be more complicated than it is on Earth.

Im not concerned about the actual baby making part we can figure that out with practice. The part thats tricky is the fine-tuned and carefully orchestrated process of human development, particularly in the brain. Cells inmicrogravitydontgrowexactly like cells on Earth, and a whole bunch of them in a developing babys brain may not grow exactly the same either.

Thankfully, theres a researcher for that.UC San Diego scientist Alysson Muotriisusingblossoming clumps of brain cells called brain organoids to understand how neurons proliferate, form synapses, and communicate but in space.

Inlate July, Muotri and his team sent a bunch of organoids to the International Space Station. Previous research has documented the proliferation ofHeLA cells,cancer cells,bone cellsand more, but there is limited information about the gravity-free growth of early brain cells, known as neural progenitor cells, or brain organoids. Suchorganoidshave proven to be a useful model for understanding brain development, so understanding how they develop in the microgravity of space could demonstrate the ways in which human brain development might be affected if we ever become a space-faring society.

Muotri has long been intrigued by research in space, especially theNASA twins study. A while ago, he half-seriously talked about the idea of doing his own biology space study with one of his collaborators, but nothing quite came of it. He dreamed of sending organoids to space, but didnt know if it was possible. Once he met an engineer who convinced him it was feasible to actually build a device to keep organoids alive in space, he decided it was time for takeoff.

Still, he had some trouble selling others, particularly granting organizations, on the idea. Hes funding the project out of his own salary savings and gifts to the lab, with the hope that his first wave of findings will draw attention to his work and convince funding agencies that his research is valuable.

Backed by his own money, the first task was figuring out how to keep the organoids healthyat the International Space Station.

Even on Earth, the organoids require a lot of care to ensure that they are at the proper temperature and growing conditions. For one, theyre kept in a shaker so that they are constantly suspended in a solution, without anchoring down to anything (though that wont be a problem in microgravity). But like living cells in a body, organoids require nutrients, and they also spit out waste. To support these processes, their solutions need to be changed, and the temperature and pH needs to be carefully maintained, like fish in a tank. Organoids require a lot of babysitting, and Muotri simply cant expect the astronauts to spend as much time caring for his cells as he and his students do back on Earth.

So, he collaborated withan engineering team from Kentucky that specializes in sending biological material into space.They developed a shiny red box called theSpace Tango CubeLab.

Space Tango may sound like abad 80s science fiction filmstarringAntonio Banderas, butits actually the name of the company, and the productsthey make aresomuch cooler than 80s sci-fi. The CubeLab essentially functions like a fully automated, climate-controlled mini-laboratory: it can change the media for the cells, monitor their growth, and send the data back to Earth. The astronauts just need to plug it in.

For this very first mission with the organoids, Muotri wants to see how the cells grow and proliferate. Based onprevious research,he predicts that The progenitor cells will proliferate faster and will probably generate a bigger organoid. Although a bigger brain sounds better, this might actually be a problem: if the brain and surrounding skull are too big, it might prevent birth through the birth canal. Its still speculation, but its entirely possible that maybe humans cannot have natural deliveries in space.

The other issue with faster brain development is that large brain volumes have been implicated in the development of autism spectrum disorder. In fact, having a larger brain circumference is one of the mostrobust biomarkers of autism. We dont fully understand how cell proliferation may later in life lead to intellectual problems or cognitive disability, so this gives us a model to understand that, Muotri hopes.

At the moment, we dont know much about the cellular mechanisms that microgravity could directly impact. Using genome sequencing and techniques to detectepigenetic signatures, Muotris team will look to see if the genomes of the organoids have changed. There is definitely an epigenetic signature that changes neurons in space, Muotri insists, thats what we want to figure out.

Of course, organoids cant capture brain developmentin uteroin its full complexity. However, this study could point us to important considerations before we pack our space bags. For example,itspossible that people with certain genetic backgrounds are less susceptible to the (lack of) pressures of microgravity and might fare better in space. However far-fetched, the social implications are staggering. If it turns out that some genetic backgrounds are better adapted to have babies in space, would this dictate who could become space-faring?

Lastly, Muotri would like to compare organoids generated from cells of healthypatients to those from people with Alzheimers or Parkinsons disease. In 2011, a lab down the hall from Muotris at UC San Diego showed thatneurons derived from schizophrenic patientswere different than those derived from neurotypical patients. However, similar in-the-dish research on diseases of the aging brain have been limited. Organoids closelyresembleyoung neural tissue, and it is a lot of work to keep them alive until they start to look like an aging brain. When Muotricompared neurotypical and Alzheimers organoids in Earths gravity, they were indistinguishable. However,this might not be true in space: Maybe in the microgravity of space the organoids will age faster, and we could reveal their [Alzheimers] phenotypes.

Muotri would also like to send the organoids up with even more sensors, including recording arrays that can actually measure the electrical activity of the organoids while theyre in space. Such data could provide clues about the functionality of these brain clumps, in addition to their genetic and anatomical signatures.

Muotris energy and enthusiasm for the project is palpable. But he has one big concern: when the mini-brains were sent into space, there was a 24-hour black out period during launch preparation over which the Space Tango couldnt send back data. Muotri confessed that this was his biggest worry for the mission. But, he still laughed heartily, We just have to hope that everything is going to be okay.

Ashley Juavinett, PhD is a neuroscientist, educator, and writer. She currently works as an Assistant Teaching Professor at UC San Diego, where she is developing novel approaches to teaching and mentoring folks in neuroscience. Follow her on Twitter @analog_ashley

A version of this article was originally published on Massives website as There might be some problems when we try to make babies in space and has been republished here with permission.

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Why making healthy babies in space should be quite the adventure - Genetic Literacy Project