Immunomic Therapeutics Announces Presentations at Upcoming Scientific and Medical Conferences – Business Wire

ROCKVILLE, Md.--(BUSINESS WIRE)--Immunomic Therapeutics, Inc., a privately-held clinical stage biotechnology company pioneering the study of nucleic acid immunotherapy platforms, today announced that Immunomic scientists will present data from its oncology programs at the following scientific and medical conferences.

The data to be presented at the conferences will show the broad promise of Immunomics pipeline and the productivity of our UNITE proprietary technology platform, said Dr. Teri Heiland, Chief Scientific Officer. We are committed to advancing our research into the clinic for patients in the years ahead.

Upcoming Medical & Scientific Conferences:

About UNITE

ITIs investigational UNITE platform, or UNiversal Intracellular Targeted Expression, works by fusing pathogenic antigens with the Lysosomal Associated Membrane Protein, an endogenous protein in humans, for immune processing. In this way, ITIs vaccines (DNA or RNA) have the potential to utilize the bodys natural biochemistry to develop a broad immune response including antibody production, cytokine release and critical immunological memory. This approach could put UNITE technology at the crossroads of immunotherapies in a number of illnesses, including cancer, allergy and infectious diseases. UNITE is currently being employed in Phase II clinical trials as a cancer immunotherapy. ITI is also collaborating with academic centers and biotechnology companies to study the use of UNITE in cancer types of high mortality, including cases where there are limited treatment options like glioblastoma and acute myeloid leukemia. ITI believes that these early clinical studies may provide a proof of concept for UNITE therapy in cancer, and if successful, set the stage for future studies, including combinations in these tumor types and others. Preclinical data is currently being developed to explore whether LAMP nucleic acid constructs may amplify and activate the immune response in highly immunogenic tumor types and be used to create immune responses to tumor types that otherwise do not provoke an immune response.

About Immunomic Therapeutics, Inc.

Immunomic Therapeutics, Inc. (ITI) is a privately-held, clinical stage biotechnology company pioneering the development of vaccines through its proprietary technology platform, UNiversal Intracellular Targeted Expression (UNITE), which is designed to utilize the bodys natural biochemistry to develop vaccines that generate broad immune responses. ITIs UNITE platform could potentially have broad therapeutic applications in oncology, including viral antigens, cancer antigens, neoantigens and antigen-derived antibodies as biologics and ITI has built a large pipeline from UNITE with six oncology programs and two allergy programs. ITI has entered into a significant allergy partnership with Astellas Pharma and has formed several academic collaborations with leading Immuno-oncology researchers at Fred Hutchinson Cancer Research Institute, Johns Hopkins University of Medicine, and Duke University. ITI maintains its headquarters in Rockville, Maryland. For more information, please visit http://www.immunomix.com.

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Immunomic Therapeutics Announces Presentations at Upcoming Scientific and Medical Conferences - Business Wire

Report on GM corn-derived animal feed likely to be taken up today – The Hindu

Amid growing demand for permitting import of animal feed derived out of Genetically Modified (GM) crops, the Genetic Engineering Appraisal Committee (GEAC), the countrys apex biotechnology regulatory body, is expected to take up a report on the guidelines for import of Dried Distillers Grains with Solubles (DDGS) derived out of GM corn at its meeting scheduled in New Delhi on Monday.

A sub-committee constituted by the GEAC, headed by Lalitha Gowda, a retired scientist from the Central Food Technological Research Institute (CFTRI) in Mysuru, has already submitted a report on the guidelines for import of DDGS for livestock and aqua feed.

The GEAC meeting to discuss the report assumes significance in light of the severe scarcity of corn, a key source of animal feed for the burgeoning poultry industry in the country, following the failure of maize crop on account of drought and disease. A number of applications from the poultry industry seeking permission to import GM corn and soyabean are pending.

The sub-committee also included representatives from the agriculture and poultry sectors, the Food Safety and Standards Authority of India, National Dairy Research Institute, and the Directorate General of Foreign Trade. Though its report has been submitted, it up to the GEAC to a take a decision on permitting import.

The report was submitted along with an elaborate background note on DDGS. Corn that is grown in the United States and many other countries is GM corn, which is also used for producing bio-ethanol. After the starch content in the corn is fermented, the remainder is rich in protein and other nutrients and can be used as animal feed. This byproduct, DDGS, is also used as animal feed in the U.S. and elsewhere.

Dismissing the concerns expressed by anti-GM crusaders over the import of animal feed derived out of GM crops into the country, a food scientist ruled out the possibility of GM food entering the food chain when human beings consume livestock fed on a GM diet. Any food that we eat gets digested and broken down into very small molecules or building blocks. So when it gets broken down into the building blocks, it cannot reform again. The body cannot absorb Genetically Modified DNA.

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Report on GM corn-derived animal feed likely to be taken up today - The Hindu

Study: Any Amount of Running Reduces Chance of Death by 20 Percent – Newsweek

Any amount of regular running is associated with staving off a premature death, according to a new study.

The study, conducted by researchers from Australia's Victoria University and published in the British Journal of Sports Medicine, was based on data acquired by 14 earlier studies that studied the habits and longevity of six cohorts, for a total of 232,149 British adults. These people were followed for periods ranging between 5.5 and 35 years.

A total of 25,951 people died during the course of the study, and the researchers found that running was associated a 30 percent lower chance of death from cardiovascular disease and a 23 percent chance of dying from cancer. Runners were 27 percent less likely to die of any cause.

According to reporting by the Guardian, the research team went on to investigate whether the duration or frequency of the subjects' runs affected their longevity, but found no association. Running just 50 minutes per week correlated with longevity.

"Compared with 'sedentary' non-runners, those who ran

In conclusion, the study's authors suggested that nearly any amount of running can help a person live longer. "We found no evidence that mortality benefits increase with greater amounts of running," the researchers wrote.

"Increased rates of participation in running, regardless of its dose, would probably lead to substantial improvements in population health and longevity," the study extrapolated. "Any amount of running, even just once a week, is better than no running, but higher doses of running may not necessarily be associated with greater mortality benefits."

The findings "could make running an ideal activity for those of who want to stay healthy but are short on time," according to Healthline.

But avid runners should not necessarily cut back on their exercise because there is no benefit in running more.

"Any running is probably good for your health and you can achieve those benefits by running even just once a week or running 50 minutes a week," Dr. eljko Pedii, principal author of the study, told the Guardian. "But that shouldn't discourage those who run more than that amount, who maybe enjoy running three times a week or six times a week."

The scientific community, of course, has known for some time that cardio-respiratory exercise like running carries health benefits that can lead to a longer life.

"Exercise has been shown to reduce many of the factors that lead to heart disease so it reduces diabetes, it reduces hypertension," Dr. Michael Chan, an interventional cardiologist in Orange, California, told Healthline.

However, the authors of the study wrote that more research needs to be conducted to understand exactly how running relates to lower risks of dying from cardiovascular disease and cancer.

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Study: Any Amount of Running Reduces Chance of Death by 20 Percent - Newsweek

Budget cuts and longevity | Letters To Editor – Fairbanks Daily News-Miner

To the editor: I concur with Melissa Brown who wrote the Inside Business Column, Theres is a lot in the world to be hopeful about (Daily News-Miner, Oct. 20). However, her column does not accurately depict the ever-widening disparity between the rich and poor that includes a disparity in life expectancy.

According to a 2016 article in The New York Times, experts have long known that rich people generally live longer than poor people. But a growing body of data shows a more disturbing pattern: Despite big advances in medicine, technology and education, the longevity gap between high-income and low-income Americans has been widening sharply. Consequently, the poor are losing ground not only in income but also in years of life, the most basic measure of well-being.

The Robert Wood Johnson Foundation publishes life expectancy data byZIP code. According to the foundation, the U.S. national average life expectancy is 78.60 years. The Alaska average is 78.10 years. However, I just recently moved from Goldstream ValleyZIP code of 99709 to Turner Street, 99701, in South Fairbanks, and based on my address change, my life expectancy has been drastically reduced by over10 years from (above national average) 81.20 years in Goldstream Valley to (well below national average) 71.00 years in South Fairbanks.

TheNew York Times article points out that smoking, obesity, access to health care, and the prescription drug epidemic have helped drive the disparity.

With the recent budget cuts to the Fairbanks Rescue Mission, The Door, and the Pioneers Home, that chasm of economic and social inequality is only going to widen in Fairbanks communities.

The message of the budget cuts is that this administration does not care that much about certain Alaskanswho just happen to reside inZIP code 99701, which include our homeless neighbors, runaway teens, and senior citizens.

Not all Alaskans are enjoying the same prosperity and progress as those residing in the capital, and it would serve us better if our governor looked out for the health and well-being of all Alaskans, including the elderly, those living in homeless shelters,and those out on the streets.

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Budget cuts and longevity | Letters To Editor - Fairbanks Daily News-Miner

Old pinyons and the climate of hope | Outdoors – Montrose Daily Press

There are 14 numbered posts on Black Canyons Warner Point Nature Trail. They are keyed to pages in a booklet that visitors pick up at the trailhead which describes the trees of the woodland along the trail. Rotted with age, we gradually replaced them this fall with new ones; anchoring them in the rocky, shallow soil.

The work takes time, except for post number 13 at one of the aged pinyon pines near the end of the trail. The marker was fairly worn, but we pulled it out with little trouble. It was the last one for that day, so we could sit under the shade of the trees spreading branches for a short break.

We dont exactly know the age of this tree, but studies in the 1940s and 1950s of tree rings from some nearby specimens, revealed ages that today approach 900 years. It started me to wonder about longevity in pinyon pines compared to that of people.

Modern medicine, in the human world, suggests that longevity might be realized by genetics, as DNA is gathered to study age-related diseases. Research related to the sequence of genes in the DNA could unlock the secrets of Illnesses like Alzheimers or Lou Gehrigs Disease (ALS).

Species, perhaps all species, have DNA (a sequence of traits) that could mean healthier or less healthy individuals. In the drought of 2002 2004, large stands of pinyon pines in New Mexico and Arizona succumbed to lack of moisture. Their weakened condition opened the door to ips beetle attack. Beetles took advantage of weakened trees, and large quantities of the trees kicked the bucket.

Back in the shade of our old pinyon, I wonder if there are traits in pinyon trees that better equip them to tolerate temperatures as they warm and conditions as they dry out. Might the gene make-up of some individual trees help them to fend off a beetle attack? Its a grand specimen; sometimes called by colleagues as the grandparent tree or the grand-pinyon tree. Over the years we have bonded with this denizen of time.

Studies have uncovered various conditions which can affect an individual pinyons chances when conditions go downhill. Soil, nutrients, rain and snow, competition from other trees, and temperature all play a part in survival success. Location is also critical. Pinyons on south facing slopes, like many on this ridge, face greater challenges than on north facing sides of hills and canyons.

A recent study of tree rings on pinyons showed that trees which have lived through wetter and drier periods, meaning they have abided through good and bad years, are more successful in getting through a warming period. On top of that, those which have survived to age 70 are more likely to live to a ripe old age than others.

An increase in heat has set the stage to a great deal of beetle kill for Douglas fir and mortality among aspen groves on the south side of Black Canyon. Overlooks and trails expose the die-off that has come about in only the past few years. Yet, after 26 years of hiking the Warner Trail, its hard not to have a concern for this grandparent pinyon that I have come to know.

I have sat with the tree as it helped me with the loss of my dad in 2006. Its fun greeting the tree at the end of an arduous hike back from Warner Point to the river. Touching its bark, smelling the piney aroma on a hot summer day, knowing that the tree is part of a community of living things similar to our own human community, and sharing the glory of old age with visitors have all been part of my relationship.

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The tree sits on the north facing slope of the canyon. It appears to have the usual advantages to survive. Its hard not knowing if it might have a genetic advantage to live through increasing heat and lower moisture in the years ahead.

People who look to the future with promise often find additional years added to their life, whether its in their genes or not. It seems that other factors can contribute to longevity in both humans and plants.

Still, pinyon trees, like the grand pinyon inspire hope. Not an uninformed, ingenuous hope. This is a hope that gives flight to love of trees and woodlands. And in that regard the longevity question is less important than the pull given by that great old tree to have a heart open to the land.

Paul Zaenger has been a supervisory park ranger at Black Canyon of the Gunnison National Park since 1993. Other park assignments include Mount Rushmore National Memorial and Glen Canyon National Recreation Area.

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Old pinyons and the climate of hope | Outdoors - Montrose Daily Press

Harvard study advances gene therapy in fighting age-related diseases – The Boston Globe

If you hit enough specific diseases, youre getting at the core aging components that are common to all of them, Church, a Wyss core faculty member, said in an interview Monday. Gene therapy gives you a testable therapy at scale in mice. And we can move from mice to dogs and then to humans. Were focusing on the reversal of age-related diseases so well be more healthy and youthful later in life.

The research is part of a broader emerging field, sometimes called geroscience. Its advocates believe that the best way to treat a variety of illnesses from cancers and heart disease to Alzheimers and macular degeneration is to attack the aging process itself.

Were taking a holistic approach, said Noah Davidsohn, a former research scientist in Churchs lab who is first author of the study. Rather than attack specific diseases, were trying to make patients generally healthier and, in the process, getting rid of as many age-related diseases as possible. Nobody wants to be old and in a wheelchair and not doing anything.

Bostons biomedical hub has become a hotbed of geroscience research.

Last winter, 16 of the worlds top longevity scientists, including Harvard scientist David Sinclair, professor of genetics and director of the Paul F. Glenn Center for the Biology of Aging, formed a Boston-based academy that will seek to spotlight medical research on extending human life and developing drugs to slow the aging process. The nonprofit Academy for Health and Lifespan Research will share research and lobby governments in the United States, Europe, and elsewhere to increase funding and create new paths to approve age-slowing therapies.

Previous studies in the field have also sought to slow aging and extend healthy life spans through small molecules that increase blood flow and endurance, or weed out zombie cells that send out toxins causing age-related maladies. But the Wyss Institute is the first to use therapy that combines genes to boost protein levels that diminish with aging. The genes were selected from a database developed over the past decade at Churchs lab.

We looked at the ones that had the biggest impact individually and then wanted to see if they would work more effectively in pairs and triples, Church said. Such an approach, he said, had the greatest potential to target multiple diseases through a one-and-done injection into the blood or muscle, a simple procedure akin to getting an influenza vaccine shot.

When deployed against obesity, type II diabetes, heart failure, and renal failure, a single formulation ... was able to treat all four diseases, according to the study published in PNAS. These results emphasize the promise of gene therapy for treating diverse age-related ailments, and demonstrate a new approach of combination gene therapy that may improve healthspan and longevity by addressing multiple diseases at once.

San Diego-based biotech startup Rejuvenate Bio, founded by Church and a pair of coauthors of the PNAS study, Davidsohn and Daniel Oliver, is pursuing a gene therapy to fight age-related diseases. The company has already begun working with the Cummings School of Veterinary Medicine at Tufts University in North Grafton to test the gene therapy combination in dogs.

Davidsohn, chief technology officer at Rejuvenate, said the company is focused for now on developing and marketing a treatment that can extend the health span of dogs, which can suffer from a range of age-related illnesses including heart and kidney problems, obesity, dementia, and hearing and vision loss similar to those afflicting humans.

His own 5-year-old dog, Bear, whom Davidsohn adopted while working in the Wyss Institute lab, was an inspiration and now holds the honorary title of chief inspiration officer at Rejuvenate. The company was launched in stealth mode about a year ago and now has eight employees.

While dogs will be an important market in their own right for the combination gene therapy, Davidsohn said, We would be happy if this ended up in humans.

Church said testing the experimental therapy in dogs is likely to take about two years. Then, if regulators approve it, clinical trials could begin in humans. But even if all goes well, he said, the gene therapy probably wont be available as a marketed product for more than a decade.

By then, he said, the cost of a gene therapy which now can top $1 million per patient for rare diseases could drop to thousands of dollars per patient in what would be a much larger market to treat multiple age-related diseases.

Some supporters of age-slowing research, such as Jay Olshansky, public health professor at the University of Illinois at Chicago, have cautioned against expectations that scientists can radically lengthen life spans. Instead, they believe, the goal should be, as Olshansky puts it, pushing out the red zone, the time of frailty and disability at the end of life.

Church, however, has a more ambitious vision.

The important thing is getting good at age reversal, he said. If age reversal truly works, there is no upper limit on how long healthy lives can be extended.

Robert Weisman can be reached at robert.weisman @globe.com. Follow him on Twitter @GlobeRobW.

Correction: An earlier version of this story incorrectly characterized the status of the collaboration between Rejuvenate Bio and George Churchs Wyss Institute Lab.

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Harvard study advances gene therapy in fighting age-related diseases - The Boston Globe

How to live longer: The simple exercise shown to extend your lifespan – Express

Ample evidence shows that regular exercise is a surefire way to boost longevity, because it lowers the risk of developing a wide range of deadly conditions.

Cardiovascular disease is one of the greatest threats to longevity, for example, but it can largely be prevented by maintaining high fitness levels and following a healthy diet.

While numerous studies demonstrate the health benefits of exercise in general or focus on specific groups of exercise, there is a growing field of research that is shedding a light on the specific forms of exercise that will extend longevity.

One of those studies, published in the British Journal of Sports Medicine, makes the case for speeding up your walking pace.

The study found that walking at an average pace was found to be associated with a 20 percent risk reduction for all-cause mortality compared with walking at a slow pace, while walking at a brisk or fast pace was associated with a risk reduction of 24 percent.

A similar result was found for risk of cardiovascular disease mortality, with a reduction of 24 percent walking at an average pace and 21 percent walking at a brisk or fast pace, compared to walking at a slow pace.

Interestingly, the health benefits were most pronounced in older age groups, with average paced walkers aged 60 years or over experiencing a 46 percent reduction in risk of death from cardiovascular causes, and fast paced walkers a 53 percent reduction.

READ MORE:How to live longer: Can eating an apple a day increase life expectancy? Dr Chris' verdict[INSIGHT]

A fast pace is generally five to seven kilometres per hour, but it really depends on a walker's fitness levels; an alternative indicator is to walk at a pace that makes you slightly out of breath or sweaty when sustained," said lead author Professor Emmanuel Stamatakis from the University of Sydney's Charles Perkins Centre and School of Public Health.

The researchers sought to establish the link between walking pace and all-cause, cardiovascular disease and cancer mortality.

To gather the findings, the researchers pooled together and analysed mortality records with the results of 11 population-based surveys in England and Scotland between 1994 and 2008 - in which participants self-reported their walking pace - the research team then adjusted for factors such as total amount and intensity of all physical activity taken, age, sex and body mass index.

"Walking pace is associated with all-cause mortality risk, but its specific role - independent from the total physical activity a person undertakes - has received little attention until now," Professor Stamatakis said.

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He continued: "While sex and body mass index did not appear to influence outcomes, walking at an average or fast pace was associated with a significantly reduced risk of all-cause mortality and cardiovascular disease. There was no evidence to suggest pace had a significant influence on cancer mortality however."

In light of the findings, the researchers are calling on public health bodies to promote walking pace as a simple and accessible way for people to help ward off developing life-threatening conditions.

Professor Stamatakis said: "Assuming our results reflect cause and effect, these analyses suggest that increasing walking pace may be a straightforward way for people to improve heart health and risk for premature mortality -- providing a simple message for public health campaigns to promote.

"Especially in situations when walking more isn't possible due to time pressures or a less walking-friendly environment, walking faster may be a good option to get the heart rate up - one that most people can easily incorporate into their lives."

The health benefits of exercise can be reaped at any age, according to research led by Alexander Mok, a doctoral researcher at the University of Cambridge in the United Kingdom.

Mok and his team of researchers examined how changes in exercise levels over time affect a person's risk of dying from any cause, as well as dying from specific conditions such as cardiovascular disease.

The findings, which are the result of a large population-based cohort study comprised of almost 15,000 people, found that high levels of exercise and increased physical activity over time correlated with a lower mortality risk overall.

Significantly, the results suggested that even if someone decided to exercise after being physically inactive, they would still both their longevity.

The greatest longevity benefits were seen among individuals who had high physical activity levels at the start of the study and increased them even more with time. These highly active people were 42 percent less likely to die prematurely from any cause.

According to the National Heart, Lung, and Blood Institute, when done regularly, moderate-and vigorous-intensity physical activity strengthens your heart muscle, and this improves your heart's ability to pump blood to your lungs and throughout your body, and as a result, more blood flows to your muscles, and oxygen levels in your blood rise.

The health said: Capillaries, your body's tiny blood vessels, also widen. This allows them to deliver more oxygen to your body and carry away waste products.

Heart-healthy eating is also essential to longevity, and the health site recommends opting for the following to protect heart health:

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How to live longer: The simple exercise shown to extend your lifespan - Express

Stress Over Your Family Can Make or Break Your Long-Term Health – VICE

If you were to ask people in committed romantic relationships who in their life has the greatest impact on their health and well-being, theyd probably point to their partner. This is because partners are, typically, who coupled-up people connect and share their daily lives with most intimately and frequently.

However, a new study published Thursday in the Journal of Family Psychology found that significant others dont have that much of an impact on their partners health. In fact, its our relationships with family membersin the study, this refers to our parents and siblingsthat matter more when it comes to our overall health. According to the study, greater family strain is linked to greater chronic health conditions down the road, and vice versa (a decline in health can lead to familial turmoil)each were found to be causal to the other. The opposite is true, too, according to the study: Good relationships with family are "associated with longevity."

The researchers studied data from 2,802 people who participated in a national survey that collected information about their health between 1995 to 2014. The survey included questions about family relationshipslike, how often do your family members criticize you or demand things of youalong with questions about their intimate relationshipshow much does your partner appreciate you or argue with you? The research team then looked at the participants health, such as whether they ever experienced a stroke, stomach trouble, or chronic headaches. They found that those with toxic family relationships had poorer health, whereas intimate partner relationshipsgood or baddidnt have a big effect on peoples health.

These findings contradict previous research suggesting romantic relationships are the most important type of relationship for adults and can therefore influence our mental and physical health the most. The researchers of the latest study suspect family members seem to have a greater impact on our health more or less because were stuck with them. Partners change, breakups happen, and, now, people tend to put off relationships until later in life, but family is always there. This isnt to say our partners have no effect on our health whatsoeverits too soon to negate all that past evidence we have claiming intimate relationships influence our cardiovascular, endocrine, immune, and neurosensory healthbut that our familys impact seems to be much more powerful.

The researchers recommend prioritizing family ties and adding in family therapy if needed. Its important that people dont leave critical, strained relationships with family unchecked, especially since they may have serious ramifications for physical health, the studys lead author Sarah Woods, an assistant professor of family and community medicine at UT Southwestern Medical Center, said.

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Stress Over Your Family Can Make or Break Your Long-Term Health - VICE

CohBar – The Pioneer In Mitochondrial Drugs – Seeking Alpha

CohBar (CWBR) is a development-stage biotech company focused on drugs based on mitochondria-based therapeutics (MBTs), an emerging class of drugs with the potential to treat a wide range of diseases associated with aging and metabolic dysfunction, including non-alcoholic steatohepatitis (NASH), obesity, type 2 diabetes, cancer, atherosclerosis, cardiovascular disease, fibrosis, neurodegenerative diseases such as Alzheimer's disease, and eventually aging itself. The company has applied for over 65 patents.

The stock is down 80% from its all-time high in January 2018, yet it has moved its lead drug into human clinical trials and has several preclinical programs in progress. This is an opportunity to own a leading company in a whole new therapeutic area at less than a $100 million market capitalization.

Dr. Pinchas Cohen, M.D., is the Dean of the USC Leonard Davis School of Gerontology. He holds the William and Sylvia Kugel Dean's Chair in Gerontology and serves as the executive director of the Ethel Percy Andrus Gerontology Center. He is on the advisory board for the Milken Institute Center for the Future of Aging. He recently received the Glenn Award for Research in Biological Mechanisms of Aging for his research on aging, neurodegeneration, cancer, and diabetes with an emphasis on the emerging science of mitochondrial-derived peptides, which he discovered.

Dr. Nir Barzilai, M.D., is the Founding Director of the Institute for Aging Research, the Nathan Shock Center of Excellence in the Basic Biology of Aging, and the Paul F. Glenn Center for the Biology of Human Aging Research, all at the Albert Einstein College of Medicine of Yeshiva University. He also directs the Longevity Genes Project, a genetics study of over 600 Ashkenazi Jewish families of centenarians and their children. Dr. Barzilai discovered several "longevity genes" in humans that were validated by others and appear to protect centenarians against major age-related diseases, such as cardiovascular disease, cancer, type 2 diabetes, and dementia.

In 2007, Cohen and Barzilai formed CohBar. The company IPO'd in January 2015 and is headquartered in Menlo Park, California.

You know that every cell in your body has the double helix of DNA - the genome. What you may not know is that most cells, with the notable exception of red blood cells, also contain mitochondria. Mitochondria generate most of each cell's supply of adenosine triphosphate (ATP), used as a source of chemical energy. Without them, you would die in about 30 seconds. Cyanide poisons by inhibiting the mitochondrial enzyme cytochrome c oxidase, thereby preventing the cells of an organism from creating ATP.

Mitochondria have their own independent DNA, inherited from the mother, which can transcribe a variety of mitochondrial proteins. There can be hundreds to thousands of mitochondria in a single cell. Mitochondrial DNA (miDNA) encodes only 37 genes, including 13 proteins essential for life and energy production in a cell. Point mutations in mitochondrial DNA have been associated with a broad spectrum of diseases, including muscle weakness, cardiomyopathy, optic nerve atrophy, retinal dystrophy, impaired hearing, and type 2 diabetes. Mitochondria control cell survival, tell old and defective cells to die, signal to the rest of the body when they are stressed, and appear to be a primary cause of aging.

Mitochondrial-derived peptides discovered by Dr. Cohen in the early 2000s are a new therapeutic paradigm. They go into the bloodstream to regulate metabolism, protect cell function, or cause cell death - the underlying factors of the diseases of aging. Humanin, the first mitochondrial peptide, is present in the brain, testes, and plasma. Humanin levels are higher in families with exceptional longevity and decline with age. A September 21, 2018, paper in Nature - Scientific Reports from Dr. Cohen's laboratory is titled: "Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans."

An earlier paper in Cell Metabolism, also from Dr. Cohen's lab, is titled: "The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance." MOTS-c is induced by exercise. This is the target of CohBar's first drug, now in Phase 1 human clinical trials for nonalcoholic steatohepatitis and obesity. It appears to have many other potential uses.

Source: CohBar

To develop mitochondrial-based drugs, CohBar first identifies and characterizes peptides with biological activity that are encoded within the mitochondria. Then it evaluates the therapeutic potential across different disease models. It files for intellectual property protection and has over 65 provisional patent applications that cover these peptides and their analogs - both composition of matter and method of use patents. The company's strategy is to "own the space" - to own the mitochondrial genome.

Once it has identified a mitochondrial-derived peptide or MDP, it optimizes its structure for potency and drug-like properties. These optimized peptides, or Analogs, are subjected to proprietary assays and validated disease models to match the greatest therapeutic potential to medical needs and market opportunities.

CohBar then has a mitochondrial-based therapeutic, or MBT, that can enter internal preclinical development to be partnered or advanced to the clinic. Many of the steps in this process are separately patentable.

Source: CohBar

CohBar has identified MDPs in type 2 diabetes, fibrosis, cancer, and other age-related diseases. All of these are in the discovery, optimization, and preclinical stages. Its lead drug, CB4211, is a MOTS-c analog in a Phase 1a/1b trial for safety and efficacy in nonalcoholic steatohepatitis (NASH) and obesity. NASH is caused by excess free fatty acid released by lipolysis from abdominal fat that flows directly to the liver. That causes liver fat deposits, inflammation, fibrosis, cirrhosis, and eventually liver cancer. Between 12 million and 20 million US patients create a $20 billion to $40 billion market, and there are no approved therapies.

CB4211 has a novel mechanism of action - it inhibits lipolysis, which reduces fatty acid release, leading to a reduction of liver fat. The preclinical data in mice showed a significant 33% reduction in the Non-Alcoholic Fatty Liver Disease Activity Score after only three weeks, improvement in liver triglycerides and plasma ALT (alanine aminotransferase), and normalization of weight in obese animals. The Phase 1a/1b trial is scheduled to end next February, and we should see results in the summer of 2020.

CohBar has identified a new peptide for type 2 diabetes that improved glucose tolerance in diet-induced obese mice. They presented a poster at the June 2019 American Diabetes Association meeting and are optimizing its potency and drug-like qualities.

A new peptide has shown a significant reduction in tumor cell growth in cultured human tumor cells. Twenty different human tumor cell types have been screened against 20 CohBar peptides, and there is evidence of effects against a broad range of tumor types. CohBar also is exploring another new peptide analog that shows antifibrotic effects in lung cells. It has been effective in a mouse model of pulmonary fibrosis. Fibrosis is a major source of organ failure in an aging population and accounts for up to one-third of all deaths worldwide.

Mitochondria play a central role in energy production, cell signaling, and communication. Mitochondrial dysfunction may play a pivotal role in chronic diseases, providing opportunities for drugs that manage and cure the disease instead of just ameliorating the symptoms. CohBar "owns the space" with over 65 patent filings and six issued patents exclusively licensed from UCLA and the Albert Einstein College of Medicine. The company has evaluated over 100 peptides encoded in the mitochondrial DNA and their analogs for potential development into novel drugs treating a wide range of diseases.

It has an experienced drug discovery, development, and partnership team. CEO Steve Engle has over 30 years of executive experience with public biotech companies. He was the Chairman and CEO of XOMA (XOMA) and La Jolla Pharmaceuticals (LJPC). Chief Scientific Officer Ken Cundy PhD has over 30 years of drug development experience at Gilead (NASDAQ:GILD) and Sterling Winthrop.

We are paying a market capitalization of well under $100 million for a company with broad patent protection of new ways to treat and cure the diseases of aging - and perhaps aging itself. There are different approaches to the difficult task of valuing any development-stage biotech stock (See here, here, and here for three examples). Obviously, if CohBar eventually develops drugs that can slow, stop, or even reverse aging, it will be an enormously successful company.

But the most conservative way to value any biotech is to calculate the ultimate value of their drugs in clinical trials and then use a high discount rate to get a value today. In CohBar's case, taking the midpoint estimate of $30 billion for the NASH market and adding $10 billion for the obesity market gives a $40 billion total available market. There are no treatments for NASH and nothing has caught on for obesity. Once CB4211 is approved, CohBar may be valued as if it can capture half of that market. But it won't be approved for about eight years, so we have to discount an ending valuation back to today using a high discount rate to reflect regulatory uncertainty and future dilution. A high 33% discount rate would give CWBR a discounted present value of $2 billion - more than 20x its current value. That may seem outrageous at first glance, but the risk is in the drug development process, not the valuation. A successful NASH and obesity drug should make CWBR worth multiple of its current value eight years from now.

CohBar is pioneering an entirely new therapeutic approach and therefore the risks of failure in human clinical trials, either for safety or, more likely, efficacy reasons are higher than usual. It will take it eight to ten years to bring its first drug to FDA approval. We can expect the FDA to be very cautious with the first mitochondria-based drugs.

The company had $14.4 million in cash and no debt at the end of September, which will carry it into the second half of 2020. CohBar's broad patent portfolio gives it, in the words of Scott McNealy of Sun Microsystems, "insurmountable opportunities" to partner out some development programs in return for milestone payments and eventual royalties. It is actively looking for non-dilutive partnerships with larger companies, but an investor has to assume there will be more financings coming. As I tell my subscribers, the second-worst news is: "Your biotech company just raised money." The first-worst news? "Your biotech company can't raise money."

CohBar is only in a Phase 1a/b safety and efficacy trial. These days, preclinical work has gotten so good that very few drugs fail their Phase 1a human safety trial. However, it is still true that efficacy in preclinical animal studies does not always translate to efficacy in human trials. Some investors may prefer to wait for the Phase 1 efficacy results to buy the stock, even if they have to pay a higher price for a de-risked situation. If mitochondrial medicine works as well as I expect it to, CohBar will offer many profitable entry opportunities over the next several years.

Disclosure: I am/we are long CWBR. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

Additional disclosure: CWBR is one of seven $20-for-$1 biotech stocks that are current Buys in New World Investor. To see more go to newworldinvestor.com/welcome-seekingalpha-reader.

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CohBar - The Pioneer In Mitochondrial Drugs - Seeking Alpha

‘Wrong on every level’: why female doctors are not the problem – The Age

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"That women are somehow the reason why things dont work when its the healthcare system itself that is overburdened and underfunded."

In emails between councillors of the Australian Salaried Medical Officers Federation, Professor Dietz wrote: "Our workforce is increasingly vulnerable - because it's increasingly female and not exactly prepared for adversity because school and uni are safe spaces'."

Dr Rhea Liang, a surgeon and researcher whose work has interrogated the experiences of women in surgery, said the statement was wrong on every level.

Gender discrimination and harassment at universities has been well-documented, she said, so the idea that women have somehow been molly-coddled is false."

Asking if women have an 'inability to cope with nastiness' is the wrong question, Dr Liang said. Why does anyone have to put up with nastiness in medicine? All the evidence suggests that a respectful workforce enhances performance.

In some ways the feminisation of the workforce - if you want to call it that - is driving change in the workplace because we are more likely to experience discrimination and harassment and are more likely to call it out.

If Professor Dietz considers this a bad effect then he and I are never going to see eye to eye.

Breast and general surgeon Dr Rhea Liang.Credit:Gold Coast Health

Dr Liang said the professor's assertion women were more expensive to train because they had a shorter work life was also incorrect.

Women have a longer lifespan in medicine we retire at an older age, so we have more longevity in the game, she said.

But do we really want to measure contribution by literally counting the dollars and number of years worked ... or do we want to look at quality of care?

Dr Khot said women were also more likely to take on the less sexy jobs and attract less money.

Dr Liang cautioned against escalating the public attacks.

His comments have been appropriately censured by the president of his college and the public rebuke has been significant, she said.

Professor Dietz is highly regarded for research and strong advocacy for women who have experience of birth trauma, co-founding the Australasian Birth Trauma Association (ABTA).

Several colleagues said they disagreed with the way he conveyed his arguments, but rejected the notion he is sexist, praising his passion and work ethic.

ABTA executive director Amy Dawes said she was deeply disappointed by his statements, recognising the incredible contribution that women make in the medical workforce as well as acknowledging Professor Dietz' own work has likely helped thousands of women.

A University of Sydney spokeswoman said the university did not condone the unacceptable comments of Professor Dietz, but its academics were entitled to express their opinions.

Kate Aubusson is Health Editor of The Sydney Morning Herald.

Rachel Clun is a journalist at The Sydney Morning Herald.

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'Wrong on every level': why female doctors are not the problem - The Age

Medinex – a business format in the world of health and longevity – AZERTAC News

Baku, November 8, AZERTAC

The Azerbaijan International Medical Innovations Exhibition and Forum, MEDINEX and the Azerbaijan International Beauty Industry Exhibition, Beauty Azerbaijan wrapped up in Baku.

The expositions brought together over 70 companies from 12 countries worldwide, including Germany, Iran, Italy, Kazakhstan, Pakistan, Russia, Japan and others. The event was organized by Caspian Event Organisers (CEO).

The exhibition has currently changed its brand, but retained the role of the platform and navigator of modern innovations in medicine. This trend during the VIP tour was noted by the Deputy Minister of Health of Azerbaijan, Elsevar Aghayev, who emphasized the effectiveness of a multi-year medical exhibition that contributes to the development of the republics healthcare system.

The growing international interest in the exhibition of businessmen and representatives of relevant companies is based on the effective economic development of Azerbaijan and the prospects of the local market.

Over the course of two days, the intense work of the exhibitions attracted professionals in the medical business, local and international manufacturers of clinical equipment, pharmaceuticals, and innovations in the field of healthcare.

Great interest was caused by goods and services exhibited under the brand "Made in Azerbaijan". Many visitors were attracted to the Medinex national pavilion of Belarus, which presented eight medical plants at once. Goods and services of Russian, Kazakh, German manufacturers have become the subject of discussion of potential distributors.

The experts called the Medinex business programme, which covered the professional and entrepreneurial activities of exhibitors, an important component in the work of the exhibitions.

The Innovation and Presentation zones, which are modern platforms for communication, dialogue and searching for effective management solutions, helped to navigate the healthcare world not only by the project participants themselves, but also by numerous visitors, including practicing doctors.

Within the framework of the session Effective Clinic Management, a professional dialogue on methods for the effective management of medical institutions and medical networks was held. During the special session "Bizimkilr" domestic experts shared their experiences with interns and students, answering questions in the format of live communication.

The exhibition also featured B2B meetings organized between exhibitors and invited buyers. The unique format of business meetings allowed manufacturers to directly present the product to potential customers, as well as discuss possible conditions for cooperation and joint projects.

According to visitors, a visit to Medinex and Beauty Azerbaijan made it possible to get acquainted with the latest industry innovations, establish and strengthen business relations, determine the vectors of development of the industry as a whole, and hold many important meetings.

Both exhibitions are supported by the Azerbaijan Export and Investment Promotion Foundation (AZPROMO), the National Confederation of Entrepreneurs (Employers) Organizations of the Republic of Azerbaijan and the Small and Medium Business Development Agency of the Republic of Azerbaijan.

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Medinex - a business format in the world of health and longevity - AZERTAC News

Tucsonans who have been moved, promoted or appointed in July-December 2019 – Arizona Daily Star

Elizabeth R. Betsy Cantwell has been appointed as senior vice president for research and innovation for UA.

Cantwell will lead the UA Office of Research, Development and Innovation, which includes the Corporate Engagement Program, Tech Launch Arizona and the UA research parks.

She will be responsible for expanding the universitys capacity for knowledge creation and discovery; integrating efforts by faculty, students, staff and executive leaders to move inventions and technologies to the marketplace; increasing the UAs connectivity with external collaborators; spearheading industry and public partnerships; and increasing total research funding.

She joins the UA after serving as the CEO of Arizona State University Research Enterprise.

Cantwell moved to higher education after working for the Lawrence Livermore National Laboratory, where she was director for economic development and currently serves as a guest scientist.

Cantwell earned a masters in business administration from the Wharton School at the University of Pennsylvania after earning a doctorate from the University of California, Berkeley, in mechanical engineering and a bachelor of arts in human behavior from the University of Chicago.

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Tucsonans who have been moved, promoted or appointed in July-December 2019 - Arizona Daily Star

How to reduce your stress and thrive, starting today! – Thrive Global

One of the most common health challenges of our time ischronic stress, which, we know can cause, or play a major role in the development of chronic disease. In the midst of multiple demands in todays world, and the fast pace of life, its hard not to be in the fight or flight mode most of the time. We all feel the weight of the stress of work, family, health, social stressors, or unexpected events. The process of evolution hasnt yet caught up to the fast- changing world of multitasking, the speed with which we communicate, make decisions and create and execute our to-do lists. Its hard to be present and appreciate the moment. While naturally programmed to seek security and control, its hard for us not to worry about things that are uncertain (read: everything in life!).

It is no surprise that the U.S. adult population reports significant levels of stress about the future, finances, healthcareto name a few examplesin recent surveys of theAmerican Psychological Association.

We cannot control the outside world, but we CAN CONTROL how we RESPOND to it.

Here are simple, yet powerful tips of how you can cultivate a practice of mindful responsiveness and awareness, rather than be in a loop of never-ending stress, worries and negative thinking.

Whether meditation is new for you, or has been something youve tried but couldnt do, I invite you to view it with a beginners mind. Allow yourself to be patient even when those thoughts are racing, and you are not paying attention to your breath, mantra, or the object of your meditation. A key aspect of the practice of meditation is that we feel acceptance of discomfort, boredom or distraction. This acceptance will lead to a sense of comfort (even with discomfort!) and greater ease with which we practice, which will lead to a more consistent practice. The results are limitless and can range fromimproved moodin individuals with depression,better sleep, andless chronic pain. Beware, consistent practice can also lead to a complete mind and body transformation and a more optimistic outlook on life!

Here are some ofmy favorite meditation resources:

In order to realize our full potential and ease our bodies into the healing mode, it is necessary that we turn down the always on fight or flight mechanism, and activate our parasympathetic nervous system. Regular mindfulness and meditation practice will help with this.

I hope that as you create your own mindfulness journey, you let your inner beauty, love and compassion shine, and that you illuminate this world with kindness and wisdom that are more powerful than ever. I trust that you will find more peace and more ease, as you follow the steps here. Keep me posted on your journey!

Namaste,Dr. Bojana

*This article originally appeared on http://www.drbojana.com

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How to reduce your stress and thrive, starting today! - Thrive Global

Gut Microbiome Puts the Brakes on Iron Absorption – Michigan Medicine

While most people in developed nations may not think much about dietary iron, almost a quarter of the global population lacks this essential nutrient.

Iron plays a critical role in providing oxygen to the bodys cells. Too little iron can lead to iron deficiency anemia and symptoms such as fatigue, heart palpitations and shortness of breath. Too much can lead to iron overload and a disease called hemochromatosis, which can cause heart failure.

Michigan Medicine researchers have unlocked a mechanism behind how the body decides whether or not to absorb iron from the food--one that involves the trillions of bacteria in our guts known as the gut microbiome.

If you have a low-iron diet, the body absorbs more of it in an adaptive mechanism to get enough, says Nupur Das, Ph.D., a research investigator in the Department of Molecular and Integrative Physiology. Our gut microbiomes are also dependent on iron. Different microbes have different iron needs to survive.

He along with Yatrik Shah, Ph.D., a professor in the Department of Internal Medicine and Molecular and Integrative Physiology, and their research team have shown that the bacteria in the gut actively compete with the human body for iron from the diet. They describe their work in a new paper in Cell Metabolism.

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Using mice, they found that certain bacteria in the gut produce metabolites that inhibit the transcription factor HIF-2 in the intestine. By doing so, the gut bacteria block iron absorption by the body.

During a pilot experiment, we found that germ-free mice [mice specially bred to have no bacteria anywhere in their systems] were resistant to anemia, says Shah, senior author on the paper. The easiest explanation is that youve gotten rid of a trillion bacteria and they no longer need iron. But interestingly, we saw that the iron absorptive mechanisms were all highly upregulated in the absence of microbiota.

In other words, without the gut bacteria there to dial back iron absorption, the bodys systems for taking iron in were turned all the way up. To confirm this observation, the group administered antibiotics to normal mice. They found that mice treated with antibiotics also saw an increase in iron absorption. Further, germ-free mice that had gut bacteria transplanted into their systems had reduced iron levels.

What these intriguing findings suggest is an unconventional treatment for iron-related disorders. In an anemic patient, you could help by getting rid of the gut microbiota. Conversely, reintroducing the microbial metabolites that inhibited the absorptive system would reduce iron absorption in patients that have iron overload disorders, says Shah.

Das and Shah note that the antibiotics are inexpensive, readily available and could hold promise for the more than 1.5 billion people globally with iron-deficiency anemia. In the anemic scenario, some places of the world cant afford food with enough iron. These findings suggest we can still improve anemia even when faced with a low iron diet, says Das.

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Furthermore, they note that there are gut specific antibiotics, reducing the risk of antibiotic resistance and can be administered to lower but not completely eliminate beneficial gut microbiota.

Says Shah, We feel that decreasing the microbialburden for a short time would outweigh some of the consequences as anemia, especially in developingnations, can be quite crippling for individuals.

Paper Cited: Yatrik M. Shah et al. "Microbial metabolite signaling is required for systemic iron homeostasis", Cell Metabolism. DOI:10.1016/j.cmet.2019.10.005

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Gut Microbiome Puts the Brakes on Iron Absorption - Michigan Medicine

Exercise the best antidepressant – Times of India

by Luke CoutinhoHolistic Lifestyle Coach- Integrative MedicineBeing chronically anxious and stressed, to a point where it starts affecting your health is not healthy. And being anxious or depressed and sedentary at the same time makes the whole situation all the more complicated. Not only does it lead to weight gain, it also slows down metabolism and causes stress eating... you end up having a lot of unused energy that should ideally be spent exercising or walking.Depression and anxiety are becoming a huge problem for human health because it upsets the entire hormonal balance. One of the best ways out of this mess is exercise. The magic of endorphins Physical movement stimulates the production of happy hormones called endorphins. Heard of runners high? Its exactly that. And mind you, exercise doesnt have to be a gym session or heavy functional training. Something as simple as a 10-15 minute walk amid nature can give you all the benefits. Endorphins are also natural pain killers. What a breather!The first thing that goes out of balance when we are stressed is our breath. It becomes quick and shallow. We either exhibit short breathing patterns or are hyperventilating. This means less oxygen going in and more carbon dioxide storage, which is why it can make us feel dizzy and nauseous. Some may even undergo an anxiety attack and pass out. So, bringing our breath back to balance is the first step towards managing stress. Breathing is one of the quickest ways to bring our bodies from a state of fight and flight to a state of rest and digest. When you break into exercise, you start breathing better which means you start taking in more oxygen. The more oxygen you inhale, the more balanced are your levels of cortisol, progesterone, testosterone, estrogen, and androgens. good distractionGenerally, when you are depressed, you tend to focus on all the negatives. You form a shell around yourself and start to move deeper and deeper into that shell. Hence, distraction can be very useful. It could be going out, speaking to a friend, listening to music, reading a book or even exercising. If you start engaging in walking or yoga or even mild stretching, you immediately create a distraction. If you are lucky and live in a place where there is contact with nature, even better. It brings instant calmness that is going to lessen your anxiety immediately. At the same time, it is necessary to practice balance and moderation even with exercise, especially if you are using it as a tool to manage your stress levels. There are some people who end up burning out through exercise. This is not a good thing because over-exercising can only add up to more stress. Listen to your body, know when to stop and focus on adequate rest and recovery.BREATHE EASYBringing our breath back to balance is the first step towards managing stress. Breathing is one of the quickest ways to bring our bodies from a state of fight and flight to rest and digest.

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Exercise the best antidepressant - Times of India

Working hand in hand with the nation’s largest integrated care system | Penn Today – Penn: Office of University Communications

The Veterans Administration has traditionally been an incubator for innovations that improve quality of life not only for veterans but also for civilian populations around the worldideas like bar-coding machines, or the discovery that daily aspirin cuts the rate of heart attacks for certain patient populations. For many years and in a range of capacities, Penns School of Nursing has been a close VA collaborator.

In 2011,for example, in addition to her role at Penn, palliative care professor Mary Ersek became director of the Veteran Experience Center, a national quality-improvement initiative housed at Philadelphias Corporal Michael J. Crescenz VA Medical Center. Rosemary Polomano, Penn Nursings associate dean for practice and a professor of pain practice, helped change the standard pain scale employed by the VA.

There are many examples of this partnership, with innovative solutions aimed at the largest integrated health system in the U.S. and the top employer of nurse practitioners, according to the Veterans Health Administration. Along the way, the VA has also built systems for tracking outcomes, leading to a treasure trove of data.

Its a great time for evidence-based research and training, saysCoy Smith, associate director of patient care services and nurse executive at the Philadelphia VA, as well as assistant dean for clinical practice at Penn Nursing. A lot of this work is transferrable to non-VA patients.

Here, a look at the work made possible because of the Veterans Health Administration-Penn Nursing collaboration.

Evidence-based health care practices are interventions based on the best, latest scientific findings. Penn sleep and health behavior researcher Amy Sawyer is currently leading 15 evidence-based quality improvement projects at the Philadelphia VA, on subjects like preventing injury in surgical patients and secondary traumatic stress in health care providers.

Change, no matter how you look at it, is hard, Sawyer says. Its hard to accept, and its hard to convey to others that change needs to happen. But implementing it can have real results, like with a recent occupational health project that involved switching the type of tuberculosis testing the VA used for incoming employees.

Unlike the standard test, called purified protein derivative or PPD, a newer test called T-SPOT.TB does not require a follow-up visit after 48 to 72 hours. During a PPD shortage two years ago, VA clinicians put in place the T-SPOT.TB procedure and followed it for a year. The program has since rolled out across the entire VA system, leading to a 29% increase in employee compliance, a 40% drop in costs, and a 50% reduction in time to clear new hires.

We used to think of quality improvement and research as separate, Ersek says. But over the years weve gotten more sophisticated. We use research methods. We sort of mimic, statistically, a randomized control trial.

To that end, Ersek and her team use the Bereaved Family Survey (BFS) in their VA work. The BFS, developed through a VA-funded research project and now used throughout the system, asks respondents to evaluate quality of care at the end of life. Its mailed to the next of kin of every veteran who dies at a VA facility or in one of several VA home-based primary care programs. Facility-level scores are calculated quarterly and sent to each facility. The Veteran Experience Center also works directly with care teams to help them interpret their scores and develop strategies to improve care and outcomes.

For example, we might identify chronically low scores on an overall item, as well as those related to communication for a specific facility, Ersek says. Training in family conferences might then follow. We continue to monitor their BFS scores during and following the training to see whether it had an impact on outcomes, she adds.

The survey is a unique way to keep a pulse on the quality of care at the VA for veterans and families, saysAnn Kutney-Lee, an adjunct associate professor of nursing who studies the effects of nursing care organizations on patient outcomes. We ask about communication with providers, whether their preferences were met for treatment, she says. We ask about emotional and spiritual support. Did they get the amount of support they wanted? Did they see a chaplain if they wanted one?

Veteran demographics are shifting from those who served in World War II and the Korean War to those who served in Vietnam. This has implications for end-of-life care, as veterans from the Vietnam era are more likely to have been exposed to dangerous combat situations, says Kutney-Lee. Many veterans were fighting in jungles and mountains; there were hidden explosives planted, all with a near-constant threat of being ambushed, she says. The nature of the direct combat situations was very different.

The way society welcomed them home was different, too. World War II vets were hailed as heroes, enjoying national support. Vietnam vets experienced the opposite, says Kutney-Lee. Things were thrown at them when they got off the planes. Today, they are less willing to talk about their experiences, something that can resurface, emotionally, at the end of life.

Its something Kutney-Lee and colleagues are trying to understand to better prepare health care providers to treat these vets. They are seeing higher rates of anxiety and post-traumatic stress, as well as more chronic illnesses that correlate with chemicals such as 2,4,5-T, an ingredient in the herbicide Agent Orange, to which many soldiers in Vietnam were exposed. In an effort to be proactive, the VAs Hospice and Palliative Care Program Office and the Veteran Experience Center are using the BFS and other data to create educational programs aimed at helping providers meet this groups unique end-of-life needs. We want the vets and their families experience to be as peaceful as possible, Kutney-Lee says.

She is involved in another project with Ersek andMargo Brooks Carthon, another Penn Nursing researcher, to study racial and ethnic disparities in quality end-of-life care for vets. Some of their work has found that the next of kin of African American vets were 50% less likely than other groups to report that their loved ones received excellent care at the end of life. The researchers want to know why.

One clue: Members of racial and ethnic minorities tend to be more sensitive to changes in nurse-staffing levels. The researchers hypothesize that in facilities where staffing is better, nurses are better positioned to meet the complex care needs of patients, which may also apply at the end of life. They have the resources they need and the time to spend with their patients, says Kutney-Lee.

Pain management entails a complex matrix of mind and body, which makes having a standard scale on which to measure pain crucial.

Penn Nursings Rosemary Polomano specializes in managing acute pain following combat-related injuries. After learning that clinicians in 28 facilities who used the standard numeric pain rating scale (0-10) found it inadequate to help patients and health care providers communicate about pain-intensity levels, Polomano collaborated with leaders from the Defense and Veterans Center for Integrative Pain Management and others to develop the Defense and Veterans Pain Rating Scale (DVPRS).

The scale integrates word anchors (from no pain to as bad as it could be, nothing else matters) with color-coding and facial expressions to help patients rate their pain.

According to Polomano, DVPRS is now the official military pain scale, with the goal of being used in all Department of Defense health care facilities. Other health systems are free to use it too, Polomano says. It is in the public domain.

Polomano also teachesPain Science and Practice, a class open to students from Penn Nursing, Penn Dental, and Penns Perelman School of Medicine. This year, in partnership with the Uniformed Services University Graduate School of Nursing in Bethesda, Maryland, 30 active-duty military personnel from their nurse anesthesia program attended the class.

Nurses work at the heart of the changes in veterans care and, therefore, help to shape the future of American health care. Much of the VAs innovative models of care delivery are due to the leadership and contributions of VA nurses, says David Shulkin, a Distinguished Health Policy Fellow at Penns Leonard Davis Institute of Health Economics and a former secretary of veterans affairs. Its often their affiliation with leading academic centers like Penn that help to ensure the VA remains at the forefront of these innovations.

Ive often felt that the VA is the best place for advanced practice nurses, saysPatricia DAntonio, the Carol E. Ware Professor in Mental Health Nursing and director of the Barbara Bates Center for the Study of the History of Nursing. One of the best jobs she says she ever had was working with VA nurses to identify and help patients with compelling emotional or psychological needs. One patient, an outgoing, lovable former boxer, would sometimes lash out and punch someone when he got upset. The VA nurses developed a plan to appoint him an unofficial nursing assistant. He followed a nurse around, carried water, etc. He had a job to do, says DAntonio. With a new sense of purpose, he could control his anger. No more punching.

Ersek was similarly drawn to the VAs work. Being involved in the military, thats a big honor. Our mission as care providers is not about prestige, she says. We get to use rigorous research methods, but I like that we stop and say its not just an academic exercise; its about using these advanced analytic methods to improve care for veterans.

That sense of purpose goes a long way. I havent practiced clinically at the VA since 1992, says DAntonio, but I still describe myself as a VA nurse. Its part of my identity. Thats true for many among the ranks of Penn Nursing faculty, who work hand in hand with the nations largest integrated care system treating a unique patient population thats changing every day.

A longer version of this feature, by Louis Greenstein, originally ran in the Spring 2019 issue of the Penn Nursing Magazine.

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Working hand in hand with the nation's largest integrated care system | Penn Today - Penn: Office of University Communications

CB2 Insights Announces Record Revenue of $4.2 million for the Third Quarter 2019; Sequential Growth of 29% – Yahoo Finance

TORONTO, Nov. 08, 2019 (GLOBE NEWSWIRE) -- CB2 Insights (CSE:CBII; OTCQB: CBIIF) (CB2 or the Company), a leading data-driven company focused on bringing real-world evidence driven from the point-of-care to the medical cannabis community, announced its results for the three and nine months ended September 30, 2019. All figures are reported in Canadian dollars ($), unless otherwise indicated. CB2 Insights financials are prepared in accordance with International Financial Reporting Standards (IFRS).

This was a milestone quarter for us at CB2, it was the first full reporting period that included the contributions of all three clinical businesses. We now operate one of the largest networks in the US, serving more than 100,000 unique patients annually, said Prad Sekar, CEO of CB2 Insights. Beyond our clinical business, we started to see our technology and research and development services begin to materialize into revenue-generating divisions. The Company has now booked approximately a quarter of a million in trials that will commence over the next 6 months, with $4 million of opportunities in the pipeline. We continue to blend the three divisions to gather Real-World Data and provide Real-World Evidence with our global partners. Going forward, the Company will remain focused on transformative growth in all areas of our business. Therefore, giving us a clear path to profitability in the near future.

Financial highlights for the third quarter ended September 30, 2019

The following are the major financial highlights of CB2s operating results for the three months ended September 30, 2019 compared to the three months ended June 30, 2019:

Corporate Highlights for the third quarter ended September 30, 2019

For a more detailed overview of the Corporate Highlights, please refer to the Managements Discussion and Analysis for the three and nine months ended September 30, 2019.

Subsequent highlights to the quarter ended September 30, 2019

Results from Operations

The following table set forth consolidated statements and financial information for the third quarter of 2019 ended September 30, 2019, and second quarter ended June 30, 2019. For further information, please refer to the Companys Managements Discussion & analysis on SEDAR at sedar.com.

* Adjusted EBITDA is defined as earnings before interest, tax, depreciation and amortization, adjusted by significant one off, non-operational expenses and partially offset by the cash impact of certain accounting treatments during the period.

Financial Measures

This news release makes references to certain non-IFRS measures, including certain industry metrics. These metrics and measures are not recognized measures under IFRS do not have meanings prescribed under IFRS and are as a result unlikely to be comparable to similar measures presented by other companies. These measures are provided as information complimentary to those IFRS measures by providing a further understanding of our operating results from the perspective of management. As such, these measures should not be considered in isolation or in lieu of review of our financial information reported under IFRS. This news release uses non-IFRS measures including "EBITDA", "adjusted EBITDA". EBITDA, and adjusted EBITDA are commonly used operating measures in the industry but may be calculated differently compared to other companies in the industry. These non-IFRS measures, including the industry measures, are used to provide investors with supplementary measures of our operating performance that may not otherwise be apparent when relying solely on IFRS metrics.

Conference Call Details (phone audio only)

CB2 Insights management team will hold a conference call to discuss our 2019 Q3 Earnings on November 8, 2019 at 9:00am EDT.

Milestone Update for Rae of Sunshine Health Services LLC

CB2 is pleased to announce that during the quarter, the acquired assets of Colorado-based medical clinic group Rae of Sunshine Health Services LLC (ROSH), operating as Relaxed Clarity has achieved their milestone and out-performed initial estimates. On September 28, 2019, ROSH was granted 900,380 shares as part of its milestone incentive payments. The team continues to demonstrate that having a strong management team, solid operational platform and economy of scale are key to achieving great success in a mature cannabis market like Colorado.

Story continues

CB2 Insights Completes Payment Obligation to MedEval Clinics LLC

CB2 is pleased to announce that it has successfully completed its payment obligation to its previously announced acquisition of MedEval Clinics LLC (See April 10, 2019 press release). The initial terms of the agreement included a combination of cash and stock paid on closing of US$150,000 and 450,000 shares of CB2 Insights with a deemed value of US$225,000 and milestone payments up to US$300,000 in additional shares over a full 12-month period, however both parties have agreed to an early payout of 100,000 shares in exchange for a discount on the total value of the acquisition. All shares issued are subject to a minimum hold period of four (4) months plus one (1) day from the date of issuance. By completing these payment obligations early, we can immediately satisfy any additional earn-out payments and are able to concentrate on continuing to grow the Colorado market driving even more impact to our bottom line

Interest Payment to Merida Capital

During the quarter, the Company issued 971,179 shares to Merida Capital as part of its interest payment on a debt note.

About CB2 Insights

CB2 Insights (CSE:CBII) is a global leader in clinical operations, technology & analytics solutions and research and development services with a mission to mainstream medical cannabis into traditional healthcare. Providing immediate market access through its wholly-owned clinical network across 12 jurisdictions, proprietary data-driven technology solutions and comprehensive contract research services designed for those in both the medical cannabis and traditional life sciences industries, CB2 Insights is able to support its partners across the entire data and research spectrum.

CB2s Clinical Operations business unit leverages extensive experience to develop clinical models with standard operating procedures, advanced workflows, training and ongoing management support. CB2 also owns and operates its own speciality clinics including the brands Canna Care Docs and Relaxed Clarity which assess nearly 100,000 patients seeking medical cannabis treatment to provide immediate market access to US-based product manufacturers for clinical trial and research programs.

The Company has built both electronic data capture (EDC) and clinical data management software (CDMS) which work to support its partners of any size to execute their data and clinical strategies.

CB2 also offers comprehensive contract research organization (CRO) services including full scale clinical trial management, trial design, monitoring and other key research functions used by licensed producers, multi-state operators and traditional pharmaceutical companies entering the medical cannabis space.

For more information please visit http://www.cb2insights.com.

For additional information, please contact:

Kim Nguyen Director, Investor Relations1.855.847.4999 ext. 212kim.nguyen@cb2inights.com

Disclaimer Regarding Financial Information

The financial information presented in this press release is based on preliminary, unaudited financial statements prepared by management, for the third quarter ended September 30, 2019. Accordingly, such financial information may be subject to change. All information contained in this press release will be qualified with reference to the interim/ unaudited financial results for the three- and nine-month period ending September 30, 2019, which will be released on November xx.2019, and will be posted on sedar.com. While the Company does not expect there to be any material changes to the financial information provided in the press release. Any variation between the Companys actual results and the preliminary financial information set forth herein may be material.

Forward Looking Statements

Statements in this news release that are forward-looking statements are subject to various risks and uncertainties concerning the specific factors disclosed here and elsewhere in CB2s filings with Canadian securities regulators. When used in this news release, words such as "will, could, plan, estimate, expect, intend, may, potential, believe, should," and similar expressions, are forward-looking statements.

Forward-looking statements may include, without limitation, statements regarding the opportunity to provide services and software to the U.S. cannabis industry.

Although CB2 has attempted to identify important factors that could cause actual results, performance or achievements to differ materially from those contained in the forward-looking statements, there can be other factors that cause results, performance or achievements not to be as anticipated, estimated or intended, including, but not limited to: dependence on obtaining regulatory approvals; investing in target companies or projects which have limited or no operating history and are subject to inconsistent legislation and regulation; change in laws; reliance on management; requirements for additional financing; competition; hindering market growth and state adoption due to inconsistent public opinion and perception of the medical-use and recreational-use marijuana industry and; regulatory or political change.

There can be no assurance that such information will prove to be accurate or that management's expectations or estimates of future developments, circumstances or results will materialize. As a result of these risks and uncertainties, the results or events predicted in these forward-looking statements may differ materially from actual results or events.

Accordingly, readers should not place undue reliance on forward-looking statements. The forward-looking statements in this news release are made as of the date of this release. CB2 disclaims any intention or obligation to update or revise such information, except as required by applicable law, and CB2 does not assume any liability for disclosure relating to any other company mentioned herein.

No securities regulator or exchange has reviewed, approved, disapproved, or accepts responsibility for the content of this news release.

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CB2 Insights Announces Record Revenue of $4.2 million for the Third Quarter 2019; Sequential Growth of 29% - Yahoo Finance

MD Sara Gottfried Talks the Differences Between Vitamins and Supplements – coveteur.com

Its becoming pretty clear to us that the vitamin conversation is never really over. There is so much to know about the pills we pop on a daily basis, and we want to be experts on every. little. thing. While we have solved the mystery that is the multivitamin, were now asking ourselves WTF the difference is, if anything, between vitamins and supplements. Seriously, what even are ~supplements~, and why is Elle Macpherson plugging them? Were done being naive with these things, which is exactly why we consulted MD Sara Gottfried, to get some answers. You may recognize Gottfried's name from Goop Wellness as she is the one who creates one of their well known vitamin regimes (they're so good), High School Genes. When we chatted Gottfried, not only did she set a few (JK, a lot) of things straight, but she also let us know about three supplements we had no idea existed let alone should actually be taking. Prepare to be enlightened.

The actual difference between vitamins and supplements:

Supplements are any product that adds nutritional value to your diet or augments health. Vitamins are a type of supplement. Other types of supplements include minerals, herbs, or nutrients like fiber.

Is it possible to overdo it with a vitamin or supplement?

Yes. In health, theres almost always a U-shaped curve, meaning too little is bad and too much is badgetting the right dose is crucial. In addition, not everyone needs vitamins or supplements, so its important to determine whether any supplement is totally necessary. Too little vitamin A causes eye problems; too much vitamin A can cause hair loss, dizziness, nausea, headaches, coma, and even death. Too little vitamin D can cause osteoporosis, bone pain, muscle weakness, heart disease; too much can cause buildup of calcium in your blood (hypercalcemia), poor appetite, nausea, vomiting, weakness, frequent urination, and kidney problems. Consult with your doctor. In functional medicine, we track the blood levels of many supplements over time to make sure our patients are absorbing them well and getting the correct dose.

Three-lesser known supplements to get familiar with:

Chasteberry (Vitex agnus-castus)for PMS. Also known by several other terms, including chaste tree, chaste tree berry, and vitex. It is proven to reduce PMS and infertility, presumably by raising progesterone. Chasteberry, used by the ancient Greeks more than two thousand years ago, restores normal progesterone levels in the body. In Germany, where integrative medicine is practiced as the standard of care, chasteberry is approved for menstrual irregularity, PMS, and breast pain. A Stanford University School of Medicine study shows that in women with low progesterone, fertility rates are higher among those taking chasteberry.

Berberine. Blood sugar rises with age (starting at fifty), and berberine is one of the supplements proven to help you normalize serum glucose. Not only that, berberine will cool inflammation in your body, lower cholesterol, assist weight loss, and behaves like an antioxidant. Taking 300 to 500 milligrams once to three times per day has been shown to activate an important enzyme called adenosine monophosphate-activated protein kinase, or AMP, nicknamed metabolic master switch.

Alpha-lipoic acid (ALA). This powerful antioxidant significantly lowers blood sugar levels and reduces nerve-related symptoms from diabetes. [It] acts to prevent cell damage and restore the function of neurons in [diabetics]. Even with a whole-foods diet, its hard to get enough to keep your oxidant/antioxidant status in balance. ALA repairs damaged cells, and its one of the most critical anti-aging, anti-inflammatory, and antioxidant agents you can ingest. When applied as a serum, alpha-lipoic acid (5%) has been shown to reduce aging in the face over twelve weeks. ALA is 400 times stronger than vitamins C and E.

The most common misconception with vitamins and supplements:

That they are regulated by the government. Supplements, including herbal therapies (also known as botanicals), often lack the scientific scrutiny that the Federal Drug Administration requires prescription medications to have. Since the mandatory regulation is minimal, its a case of buyer beware. Quality of a product is left to the manufacturer, which means that you must take great care when choosing your supplements.

Pro tip:

Consider taking only one new supplement at a time so you are able to determine whether it is helping you. Give it at least 6-12 weeks, and if it isnt working after this period, move on to another choice.

[As always, we are definitely not doctors or medical know-it-alls. And everybody is different, so make sure to check with a doctor before trying anything!]

Photo: Trays,Herms; Supplements, HUM Nutrition

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MD Sara Gottfried Talks the Differences Between Vitamins and Supplements - coveteur.com

In Good Health: How Traditional Chinese Medicine Is Evolving In Leaps And Bounds – Hong Kong Tatler

By Oliver Giles November 08, 2019

Its been around since 3000 BC, but traditional Chinese medicine is not only survivingits thriving. Practitioners and manufacturers explain why and what the future holds

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In the future, people will send photos of their tongue via WhatsApp, says Lin Zhixiu. Hes not talking about the latest quirky internet craze or teenagers Snapchat habits. Lin is predicting how people will contact their doctors.

Lin is associate director of the school of Chinese medicine at the Chinese University of Hong Kong (CUHK), a department whose very existence may seem surprising in an era when medicine is so closely tied to technology that computers powered by artificial intelligence are diagnosing patients in Shanghai hospitals.

Everyone from toddlers to 90-year-olds comes to our clinic for traditional medicine, says Lin. I also see a growing trend of young people opting for Chinese medicine, especially when they have things like a cold, cough, flu or pain such as back or neck pain.

Hes not the only one. Rather than quietly closing shop as robots steal their jobs, traditional Chinese medicine (TCM) practitioners are arguing that there is a place for their ancient remedies in the 21st centuryand theyre generating cutting-edge research to prove it.

In 2015, chemist Tu Youyou from the China Academy of Traditional Chinese Medicine won a Nobel Prize for deriving an anti-malaria drug from sweet wormwood. Other researchers have proved traditional remedies effectiveness at tackling everything from eczema to infertility, and for the first time this year the World Health Organisation has listed TCM in its annual global compendium that instructs doctors around the world.

This scientific backing is contributing to a global boom in TCM, which as an industry is estimated to be worth about US$60 billion a year and is growing 11 per cent annually.

Theres been a big change in the image of traditional Chinese medicine, says Viola Man-Chan, an executive director of PuraPharm, a major manufacturer of traditional medicines. Were disrupting the Chinese medicine industry by changing it from a very old-fashioned industry to something that is trendy, modern and accepted by the young generations. In modern life we cant just rely on traditions; we need evidence-based science to understand how it works.

PuraPharm operates its own laboratory, which collaborates with universities around the world. Weve been working with the University of Hong Kong faculty of medicine for, I think, 10 years now and we have identified a new active ingredient in one of the herbs, Man-Chan says. Weve found that this herb has very powerful antiviral and anti inflammatory effects, which is similar or comparable to the best-selling antiviral Western medicine.

Wai Yuen Tong, a Hong Kong-based company founded in 1897 that manufactures premium Chinese medicine sought-after around Asia, is similarly investing heavily in science.

Our research and development team is not focused on creating new drug formulas, explains Vivian Tang, the companys executive director. Instead, were focusing on two aspects: how to measure and improve traditional formulas efficacy and how to translate century-old production methods and re-engineer it as modern-day mass production.

Re-engineering traditional formulas is key to the industrys newfound success with younger generations. For centuries, Chinese herbal medicine has relied on patients cooking their own medicine, normally by boiling herbs, sometimes for hours at a stretch. Many people now simply dont have the time, so manufacturers are releasing their formulas as granules that dissolve quickly in boiling water.

At the CUHK clinic, Lin estimates that half the patients opt for granules. When it comes to Wai Yuen Tongs customers, Tang believes the proportion is even higher. Ninety-nine per cent of our younger clients will never spend an hour boiling raw traditional Chinese medicine themselves, says Tang.

See also: Vivian TangFrom Wai Yuen Tong Talks Traditional Chinese Medicine

Refining recipes to pill or granule form has also made it easier for TCM to be dispensed in hospitals. The way forward for traditional Chinese medicine for me is combining it with Western medicine. This could offer the best of both systems to the patient, says Lin, who is also director of the Hong Kong Institute of Integrative Medicine.

One of the most successful examples of the disciplines being combined is in treating cancer patients.

Cancer treatmentoperations, chemotherapy and radiotherapycauses serious side effects, says Lin. Patients may lose weight, they may lose their appetite, they may feel tired all the time. In these cases, we can give them herbal medicine to try and boost their immune system. Herbal medicine can also really help digestion and improve their energy levels. This is a very common practice in Mainland China and increasingly in Hong Kong.

Despite these steps forward, the industry still commonly hits headlines not for scientific discoveries or its rapid modernisation, but for some unethical doctors continued and controversial use of animal products.

Ingredients such as rhino horn and pangolin scales have long been prized by TCM practitioners, which has decimated wild populations and driven these animals, among others, to the brink of extinction. The trade of these ingredients is now illegal in almost all countries, and academics are searching for alternatives to try to curb the black market trade.

There are almost always substitutes, and I see a big trend towards plant-based medicine, especially with millennials, who care deeply about the environment and sustainability, says Man-Chan. Feng Yibin, an associate professor at the University of Hong Kong, has found plant-based alternatives to bear bile, for example, and multiple herbal substitutes for rhino horn.

People who might choose to pop an aspirin before boiling a medicinal brew might find that TCM is finding its way into their lives in other ways.

Herbal, a cocktail bar in Beijings trendy Sanlitun district, serves drinks inspired by ancient remedies. Singaporean Jamie Koh, the founder of Brass Lion Distillery, the citys only gin brand, scoured local TCM shops for ingredients when she was developing her infusion. LVMH is also betting on increasing interest in Chinese healthcare with Cha Ling, a skincare brand that combines traditional medical knowledge and the anti-ageing properties of puer tea.

In Shanghai, entrepreneurs Jen Hau and Polly Zhang are building a whole lifestyle brand inspired by Chinese medicine. The pair launched Jova Health in 2013 with three different blended juices, all of which were based on traditional medical recipes.

Purify is a pear juice-based drink with rock sugar, to purify your lungs and your system; Replenish has a lot of iron and vitamins and is great for women having their period; and Nourish is a great substitute for milk drinksits almond milk and almond is a big ingredient in traditional Chinese medicine, says Hau.

Since then, theyve expanded their drinks range, released candles made using classic ingredients from TCM and launched Jova Senses, wellness classes that combine yoga, meditation and TCM.

As a millennial herself, Hau understands why TCM appeals to younger generations. It is all about implementing things into your daily life to improve your health, and its all natural, says Hau.

As opposed to, I dont feel well so Im going to take a painkiller. Or, I dont feel well so Ill drink some cough syrup, and on and on. Those are very short-term solutions, while Chinese medicine is a very long-term way of conditioning your body to put you in better health. And when you do need to see a doctor, the approach is very different. Chinese medicine always looks for the root cause, and its a lot less invasive, says Lin.

Its so non-invasive that, in five years, when you feel a cold coming on, you might not even need to see a doctor. Youll simply stick your tongue out and snap a photo from the comfort of your bed.

In Chinese medicine, we always look at the tongue. It says a lot about your health, says Lin. If the patient WhatsApps a photo of their tongue and leaves a message about symptoms, the doctor can make a diagnosis and write a prescription. I think that will become more and more popular in the future.

See also: Urban Escapes: Where To Find The Cleanest Air In Asia

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In Good Health: How Traditional Chinese Medicine Is Evolving In Leaps And Bounds - Hong Kong Tatler

Medical doctors will soon rally traditional medicine for integrative treatment of ailments – Guardian

Recently, World Health Organisation (WHO) pledged support to the federal government to integrate traditional medicine into national healthcare, what is your take on this?That is hugely awesome and no doubt it is an encouragement for practitioners of traditional medicine that the days of more honour and recognition for our practice is here. As it is said, the future is here. With this kind of support from the global apex health body, it further goes to show that the world knows and confirms that indeed nature cures. Of course, this is not the first time we would be telling the masses that nature has cure for all that affects our body, but this kind of recognition speaks volume to the wide acceptability of our call. In no time, we would begin to see even medical doctors rallying around traditional medicine for integrative treatment for ailments just as we have seen in other climes where the practice of natural medicine has been more established and controlled. Even as natural therapies continues to bask in the glory of its richness and wellness as an efficient cure system, this kind of support at this time in our country is needed to harness all the potentials. We look forward to seeing in practice and learning of this healthcare system, which we believe will fight against incompetence and lack of best practice that ravages the traditional medicine.

What is the likely outcome of this synergy?If by this you mean the synergy the integration of traditional medicine into the healthcare system will birth, then one thing I would say is, let us look at the Chinese and the Indians. What did the synergy foster for them? A sustainable healthcare system, assured healthy living and a population living more hale and hearty. This is because with traditional medicine and implementation of best practice which is a function of structured learning, just as we have for the orthodox medicine, will not just treat the surface of ailments or treat the effects of diseases, rather traditional medicine will imbibe the very message of natural treatment therapies which is to treat the root cause of every diseases and create true cure for the body. As abundantly blessed as the Nigeria has been blessed with almost all kinds of herbal and other traditional medicine therapies, we are yet to harness this into both health wellness and economic growth. The reason for this being that there are a lot of quacks in the practice of traditional medicines.

But with a synergy like this, it will bring forth more standard which will enable us to sieve the shaft away from the substance, making the business of health primarily based not on making money but that of saving lives and empathising with those with ailments of different kinds. Lastly, with a synergy like this, we would find standards in our traditional healthcare management system just as I saw in my recent travel to Malaysia for an International Course on Neuroacupuncture and Non Invasive Pain and Paralysis Management.

How do you think traditional medicine can fit into healthcare?Traditional medicine, which is primarily about utilising nature in the process of administering cure, is synonymous to effective healthcare just as life is synonymous to living. Any healthcare system that is yet to embrace traditional medicine as a mode of treatment is not only lagging behind, it is almost nonexistent because the very basis upon which living is formed, that is nature, has been neglected. I remembered when I was learning at the Indian Board of Alternative Medicine where I first bagged my Doctor of Natural Medicine after having graduated from University of Ilorin as a first degree holder in Biochemistry, my learning made it clear that even the synthetic drugs used in curing humans has a greater element of natural cure in it. Why then would someone not want to go to natural cure through expert guidance and make-up to cure that which affects the body.

You have had success in treating patients with chronic and severe pain within few minutes, what can you say about this?We as doctors are only applying treatment protocols with best practice, we cannot totally lay claims to our knowledge and practice as the basis for the success. God Almighty cures and no doubt about that. But then as humanly possible, yes, it is true that I am having success in treating chronic pain related ailments such as sciatica, paralysis patients and so on and within minutes, my patient experience instant relief from pains they have suffered in years. In fact, my teacher that taught me this treatment system would treat over 200 patients in a day when I was learning with him. These are patients with different chronic pain and paralysis related health issues. So, the treatment methodology I employed is Non-Invasive Neuroacupuncture which I learnt during my last learning tour to Kuala Lumpur, Malaysia. One thing I am passionate about is to continue to research and learn the best and less troubling ways to bring smile to the faces of my patients. This is why aside from putting a lot of efforts into research; I have interest in continuous learning which has made me travel to Colombo, Sri-Lanka where I bagged my Doctor of Medicine in Acupuncture. Still, I am not stopping. My aim is also to bridge calibre in Traditional African and Chinese Medicine to give pristine admiration to natural healing.

How does neuro acupuncture work? Arent there side effects of this therapy?No. Neuroacupuncture is a very good treatment procedure with no known side effects. This treatment is based on knowledge of traditional acupuncture and neurology. It is done by inserting acupuncture needles into loose areolar tissue layer of the scalp to stimulate the brain neurons of the underlying area. Since the skull protects the brain and there are no organs in the scalp to injure it is a very safe treatment. Its a non-invasive procedure and works by stimulating the brain cells that are related to the impaired functions. The mechanism is three-fold: to wake-up the brain cells that are not dead but lacking in proper functioning, to encourage the recruitment of healthy brain cells to perform the lost function and to promote a healthy reintegration of the brain system. It does not only treats pains but also paralysis, Parkinsons Disease, multiple sclerosis, traumatic brain injury, spinal cord injury, motor neuron diseases, Alzheimers disease, restless leg syndrome and attention deficit hyperactivity disorder and other neurological issues. Scalp acupuncture can help regain speech in all kinds of Aphasia: expressive, receptive, anomic or global. The speed and amount of recovery vary with the individual and the severity of damage but progress is usually readily seen within few minutes of treatment.

You treat people with cancer and other chronic diseases, is it only acupuncture that you are using or there is another treatment method you are adopting?First thing I will say here to clarify the misconceptions that there are some incurable diseases is that which I have said in past interviews. I as a person do not believe there are incurable diseases, but I know for sure that there may be incurable cases. So this has influenced my belief and interest in always researching on how we can improve on treatment because people are out there in pains and need healing. Why then would we not as practitioners continue to make research on how to improve the wellness of the people. So going back to the question, no, it is not Acupuncture alone that we use as the treatment protocol. We utilise a system called integrative system that allows us to use different therapies in treating our cancer patients. But then Acupuncture is an integral part of that protocol because it helps us manage pain for our cancer patients. We integrate different therapies in order to achieve success as early as possible. Our local herbs and spices play major role in treating these conditions, also, massage, diet and nutrition therapies. I combine as many therapies as possible. For cancer, up-to seven therapies will be combined depending on the type of cancer. I hold that not any therapy is self-sufficient. Every therapy has its own limitations. Combining them will bring meaningful results and may lead to cure in maturation of time.

Visit to your centre shows some children affected by Autism recovering fast, how do you manage to achieve this?Yes, we have really worked on autism and sincerely I would say that we can assist autistic children get better. We have been successful in about three cases and many more successes are approaching by Gods grace. The major treatment methods are herbalism and neuro acupuncture. Also, administration of Camels milk, black seed and natural honey have really been effective in alleviating the symptoms associated with autistic especially speech difficulty and walking. We appeal that the WHO and FG continue looking into traditional medicine. No doubt, there is a need for integrative medicine in order to achieve better results.

You have treated many HIV patients, but not many are too keen to face the media due to the stigma attached to it, what are you doing differently?Should I say its not curable so that I wont get held? Well, let me simply say the truth. There is no diseases that isnt curable if given integrative natural approach and enough treatment durations. HIV is one of the easiest diseases to treat but unfortunately many still believe its cure is just a claim. There are natural herbs and spices that get rid of this virus in the body within few months, no doubt. Some of what I use are garlic, Indian costus and black seed. They are very potent and give good result if taken for many months. How to prepare, required dose and dosages for different individuals is key and thats where I come in.

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Medical doctors will soon rally traditional medicine for integrative treatment of ailments - Guardian