Monthly Archives: January 2014

Dr. Avery is a Dad! Grey’s Anatomy Doc Jesse Williams Welcomes Daughter with Wife Aryn Drake-Lee – Video

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Dr. Avery is a Dad! Grey #39;s Anatomy Doc Jesse Williams Welcomes Daughter with Wife Aryn Drake-Lee
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Dr. Avery is a Dad! Grey's Anatomy Doc Jesse Williams Welcomes Daughter with Wife Aryn Drake-Lee - Video

Raymark Launching Next Generation Of Retail Mobility And Analytics Solutions At The National Retail Federation’s BIG …

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Raymark is delighted to announce the upcoming launch of its next generation of retail enterprise solutions for mobility and analytics at the National Retail Federation's BIG Show 2014, in New York on January 13th and 14th. The two new solutions, Raymark Mosaic Point of Sale and Raymark Affinity Analytics, will complement the end-to-end suite of Raymark retail enterprise applications with innovative tools for mobile transaction processing and customer engagement as well as omni-channel retail analytics.

Raymark Mosaic Point of Sale will be a game changer in the world of retail mobility because of its device agnosticism: the application is not locked into any particular hardware model or operating system. Retailers gain the freedom to use the devices they want, and, as new devices, form factors and operating systems become available, the application's HTML5 technology will enable it to evolve with new trends in mobile hardware. The solution's real-time capabilities make it a must-have for up-to-the second access to product information, including price lookup and inventory visibility from anywhere in the retail network, even distribution centers. Raymark Mosaic Point of Sale works in harmony with Raymark Mosaic Clienteling to provide a holistic tool for building customer relationships and providing superior service.

"In order to remain competitive in an omni-channel marketplace, retailers must meet and exceed increasing consumer demands for rapid, informed service in brick-and-mortar locations" says Marc Chriqui, President of Raymark. To empower store associates with tools to provide an outstanding customer experience, Raymark is introducing its newest mobile Point of Sale solution, which provides the tools needed to serve customers from anywhere along with easily-accessible, in-depth customer information that makes up-selling and cross-selling easier than ever.

For head office and management users, Raymark's new Affinity Analytics solution is a powerful yet incredibly easy-to-use tool to create and view graphical dashboards and reports based on transactional, product or customer profile data from any omni-channel source, including POS, e-commerce, merchandising, CRM and many more. Users can analyze customer behaviors and demographics alongside store, product, vendor and promotion performance with interactive visualization tools to drill-down and organize data in a way that makes it simple to zero in on key insights. The solution includes over 25 graphical reports and dashboards that can be viewed from any web-enabled device, including handheld mobile devices, PCs and tablets.

"We believe these new solutions will empower users at every level of the retail organization with the insights and tools to provide the ultimate customer experience" added Marc Chriqui, President of Raymark. Raymark will be demoing the new solutions at booth 719 at the National Retail Federation's BIG Show 2014.

About Raymark For 25 years, Raymark has been empowering retail with world-class enterprise software solutions to optimize stock turns, build customer loyalty, improve associate productivity and increase sales. Raymark's integrated, end-to-end suite of retail technology solutions operate in real-time and provide retailers with everything they need for store operations, customer-centric retailing, planning and inventory management, reporting and analytics. To learn more, visit http://www.raymark.com/about.

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Nature study discovers chromosome therapy to correct a severe chromosome defect

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PUBLIC RELEASE DATE:

12-Jan-2014

Contact: Jessica Studeny jessica.studeny@case.edu 216-368-4692 Case Western Reserve University

Geneticists from Ohio, California and Japan joined forces in a quest to correct a faulty chromosome through cellular reprogramming. Their study, published online today in Nature, used stem cells to correct a defective "ring chromosome" with a normal chromosome. Such therapy has the promise to correct chromosome abnormalities that give rise to birth defects, mental disabilities and growth limitations.

"In the future, it may be possible to use this approach to take cells from a patient that has a defective chromosome with multiple missing or duplicated genes and rescue those cells by removing the defective chromosome and replacing it with a normal chromosome," said senior author Anthony Wynshaw-Boris, MD, PhD, James H. Jewell MD '34 Professor of Genetics and chair of Case Western Reserve School of Medicine Department of Genetics and Genome Sciences and University Hospitals Case Medical Center.

Wynshaw-Boris led this research while a professor in pediatrics, the Institute for Human Genetics and the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UC, San Francisco (UCSF) before joining the faculty at Case Western Reserve in June 2013.

Individuals with ring chromosomes may display a variety of birth defects, but nearly all persons with ring chromosomes at least display short stature due to problems with cell division. A normal chromosome is linear, with its ends protected, but with ring chromosomes, the two ends of the chromosome fuse together, forming a circle. This fusion can be associated with large terminal deletions, a process where portions of the chromosome or DNA sequences are missing. These deletions can result in disabling genetic disorders if the genes in the deletion are necessary for normal cellular functions.

The prospect for effective counter measures has evaded scientistsuntil now. The international research team discovered the potential for substituting the malfunctioning ring chromosome with an appropriately functioning one during reprogramming of patient cells into induced pluripotent stem cells (iPSCs). iPSC reprogramming is a technique that was developed by Shinya Yamanaka, MD, PhD, a co-corresponding author on the Nature paper. Yamanaka is a senior investigator at the UCSF-affiliated Gladstone Institutes, a professor of anatomy at UCSF, and the director of the Center for iPS Cell Research and Application (CiRA) at the Institute for Integrated Cell-Material Sciences (iCeMS) in Kyoto University. He won the Nobel Prize in Medicine in 2012 for developing the reprogramming technique.

Marina Bershteyn, PhD, a postdoctoral fellow in the Wynshaw-Boris lab at UCSF, along with Yohei Hayashi, PhD, a postdoctoral fellow in the Yamanaka lab at the Gladstone Institutes, reprogrammed skin cells from three patients with abnormal brain development due to a rare disorder called Miller Dieker Syndrome, which results from large terminal deletions in one arm of chromosome 17. One patient had a ring chromosome 17 with the deletion and the other two patients had large terminal deletions in one of their chromosome 17, but not a ring. Additionally, each of these patients had one normal chromosome 17.

The researchers observed that, after reprogramming, the ring chromosome 17 that had the deletion vanished entirely and was replaced by a duplicated copy of the normal chromosome 17. However, the terminal deletions in the other two patients remained after reprogramming. To make sure this phenomenon was not unique to ring chromosome 17, they reprogrammed cells from two different patients that each had ring chromosomes 13. These reprogrammed cells also lost the ring chromosome, and contained a duplicated copy of the normal chromosome 13.

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Nature study discovers chromosome therapy to correct a severe chromosome defect

The democratization of medical science

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Vinod Khosla has stirred up some controversy in the healthcare community over the last several years by suggesting that computers might be able to provide better care than doctors.This includes remarks he made at Strata Rx in 2012, including that, We need to move from the practice of medicine to the science of medicine. And the science of medicine is way too complex for human beings to do.

So when I saw the news that Khosla Ventures has just invested $4Min Series A funding intoLumiata (formerly MEDgle), a company that specializes in healthcare data analytics, I was very curious to hear more about that companys vision.Ash Damle is the CEO at Lumiata.We recently spoke by phone to discuss how data can improve access to care and help level the playing field of care quality.

Ash Damle: Were bringing together the best of medical science and graph analytics to provide the best prescriptive analysis to those providing care. We data-mine all the publicly available data sources, such asjournals, de-identified records, etc. We analyze the data to make sure were learning the right things and, most importantly, what the relationships are among the data. We have fundamentally delved into looking at that whole graph, the way Google does to provide you with relevant search results. We curate those relationships to make sure theyre sensible, and take into account behavioral and social factors.

Our goal is to apply the best of medical science in every health interaction possible. In the long term, we want to optimize health. In the short term, we want to optimize care.

Ash Damle: Right now we have care as a service, but not necessarily health as a service. Care is reactive, while health is proactive. If you had a physician who could spend three hours a week looking over all of your data, he could tell you the things you need to do each week to stay healthy and be proactive. But thats not efficient. So we want to bring data science and the power of big data to bear, and we want to provide that anytime, anywhere.

Ash Damle: Theres so much medical science out there, but its really hard to apply it all within a limited amount of time. Were just in the beginning of the datification of health, but if we can computationalize medical science with all the power and nuance that computers and data analysis have to offer, then suddenly we have a way to apply the best of medical science to everyones care all the time.

The advent of the variety and volume of big data presents an opportunity to better contextually understand what is happening with the patient, and what is likely to occur in the future. Everyday we are amazed by the brilliance of physicians. We want to democratize medical science and make it easier so that all kinds of medical stafffrom advice nurses, to physicians assistants, to doctorscan apply higher quality care.

Were at the beginning of what we can do, and were excited about having such an extraordinary partner.

Ash Damle: Physicians and nurse practitioners and other providers are very empathetic people; part of why they do what they do is that they care. How do we superpower them and enable them to do the best they can by giving them the best tools?

The reality is that if a care provider is in the Southwest versus the Northeast of the United States, theyll see different things, and so the way they think about whats more likely will change based on local conditions. Experience is key and intuition is extraordinarily powerful. But intuition is the ability to synthesize huge numbers of variables and personal experience to deduce things from weak signals. In some sense, thats also what were trying to enable, because not everyone has the same level of experience that our best physicians do.We want to democratize that brilliance so that everyone gets the best care. We believe tools improving and applying the science of care should be used to augment and amplify the intangible human components.

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The democratization of medical science

DaSilva Institute Brings World-Class Medicine to Sarasota, Florida

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Sarasota, FL (PRWEB) January 13, 2014

The DaSilva Institute opened their brand new state-of-the-art medical facility in Sarasota, Florida on December 16, 2013.

The DaSilva Institute combines functional medicine with anti-aging and regenerative medicine, making it the most unique multi-specialty medical center of its kind in the U.S.

One major advantage that the DaSilva Institute has over similar centers found elsewhere in the US and overseas is its focus on autologous stem cell therapy. Used to reverse degenerative diseases and injuries, this innovative therapy involves harvesting stem cells from the patients own body fat without the controversial use of embryos, umbilical cords, placentas or donors, thus eliminating the risk of viruses and rejection.

The DaSilva Institute is also known for their expertise in bio-identical hormone replacement therapies, functional gastrointestinal disorders, mood disorders, nutritional counseling, IV nutrition and chelation, natural cancer support, regenerative orthopedics, platelet rich plasma (PRP), prolotherapy, and several new aesthetic treatments including facial rejuvenation, natural breast and buttocks augmentation and gentle liposculpture.

Guy DaSilva, MD, founder and medical director of the DaSilva Institute, states, Our vision is to make this extraordinary form of medicine accessible and affordable for people in the U.S. You shouldnt have to fly to other countries and spend tens of thousands of dollars for what you can receive in your own backyard for much less.

After outgrowing their previous office in the Lakewood Ranch area, the decision to move into a larger, more optimally equipped facility led them to the heart of Sarasota.

Dr. DaSilva states, My hope is that people will benefit from our extended menu of services and enjoy the beautiful and comforting ambiance of our new office, as well as the convenience of the new Sarasota location. And above all, we want to help more people discover health without limits.

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DaSilva Institute Brings World-Class Medicine to Sarasota, Florida