Few happy endings on 'Grey's Anatomy'

Richard Cartwright / ABC

Ellen Pompeo of "Grey's Anatomy."

By Lesley Goldberg, The Hollywood Reporter

[Warning: This story contains spoilers from Thursday's ninth season premiere of "Grey's Anatomy."]

After losing Lexie (and Teddy) last year, "Grey's Anatomy" opened its ninth season with a look to its future as Seattle Grace welcomed a new batch of interns as the deadly plane crash claimed its second victim during Thursday's season premiere.

Opening with a familiar scene -- a new intern walking Seattle Grace's halls on her way to meet a feared doctor to the same Rilo Kiley song from its premiere -- the residents-turned-attendings experienced some major role reversals as everyone is dealing with the after-effects of the crash in a different way.

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"Going, Going, Gone" was (in a way) a tribute to Mark Sloan (the departingEric Dane), who became the second fatality from the crash. The episode, which interweaved flashbacks -- complete with brand-new footage -- to Derek's wedding to Addison as well as Callie and Arizona's nuptials, flashed forward to 30 days after the crash that claimed the life of Lexie Grey (Chyler Leigh) and found most everyone back in Seattle but with a new set of hurdles to overcome: Arizona had to have her leg amputated, Cristina has moved on to Minnesota, April left the medical industry and Derek's medical future remains up in the air.

Meet the New Interns:Gaius Charles' Shane,Camilla Luddington's Jo Wilson andTina Majorino's Heather are among the new batch of interns who must contend with a "Nazi" of their own -- Meredith. While some are ahead of the curve (Jo), others have found new friends (Heather) to spend time with. Early on, Jo is bearing the brunt of Meredith's wrath, but at the same time excelling to the point where she earns her first solo surgery (which doesn't exactly go her way).

Meredith (Ellen Pompeo):Dealing with the aftermath of the crash, Meredith has gone one beyond her former dark and twisty persona into "Medusa," an attending who instills fear in her interns. She's yet to process Lexie's death and high-tails it from Mark's bedside as a way to avoid addressing the epic losses in her life. At the airport, she runs into Alex and lets him have it for leaving without saying goodbye. "Nothing is the same, everything is different, everyone is leaving and everyone is dying," she tells him. After boarding the plane for Minnesota, she's unable to fly and instead hits the bar where she has a Facetime conversation with Cristina.

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Few happy endings on 'Grey's Anatomy'

Grey's Anatomy: Shonda Rhimes Explains Killing Off Eric Dane's Character

Thursday night was a difficult evening for many a "Grey's Anatomy" fan.

Dr. Mark Sloan, aka McSteamy (played by Eric Dane), said his final farewell to the halls of Seattle Grace on the show's Season 9 premiere, after he was taken off life support and subsequently passed away.

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"Grey's" creator addressed the reasoning behind the loss of McSteamy in a blog post on Friday, writing, "For me, this [death] is the most tragic. I'm VERY attached to Mark Sloan. He's part of the fabric of the show."

Shonda explained that if Mark had lived, he would be forced to grieve for Dr. Lexie Grey (Chyler Leigh, who died in the crash during the Season 8 finale), and that storyline would've been too painful for one of her favorite characters.

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"That doesn't sound like what I want for my beloved Mark Sloan," she wrote. "So, I fought it and I debated it and tossed and turned about it but in the end, I had to do what was right for the integrity of the character... So Mark dies. And he and Lexie get to be together in a way. Their love remains true."

Another shocker? Dr. Arizona Robbins (played by Jessica Capshaw) survived the Season 8 finale plane crash, but lost part of her leg.

Jessica took to Twitter to share her relief over her character's survival.

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Grey's Anatomy: Shonda Rhimes Explains Killing Off Eric Dane's Character