TITANIUM 2012 Aerospace Materials & Processes Represented By Boeing, Dassault Aviation, Honeywell, Rolls Royce …

DENVER, Sept. 25, 2012 /PRNewswire/ --Aerospace Materials and Processes, a speaker panel at TITANIUM 2012, the 28th annual conference and exhibition, hosted and organized by the International Titanium Association (ITA), will examine titanium manufacturing techniques and alloy selection, both of which are critical for demanding aerospace applications. Titanium Metals Corp. (TIMET), Dallas, will sponsor the panel, which will be moderated by Dr. Yoji Kosaka, senior manager, U.S. research, at TIMET's Henderson Technical Laboratory, Henderson NV.

A paper by Dr. Daniel G. Sanders, senior technical fellow, Boeing Research and Technology for Chicago-based Boeing Co., will examine promising new titanium alloys and production methods now under development at Boeing, which may offer advantages over the existing alloy options. With the recent launch of the Boeing's 787 jetliner as a backdrop to his remarks, Sanders will note the ongoing interest in novel titanium alloys, as they are compatible with composite materials because of their similar galvanic properties and coefficient of thermal expansion.

Matthieu Pachoutinsky, metallic material and processes engineer at Dassault Aviation of France, will provide an overview of titanium applications in Dassault airframes. He will focus on structures using forged cast parts, superplastic forming and diffusion bonding. "Whereas landing gear or engines manufacturers take the benefit of the wide range and high quality of material manufacturer's portfolio, Dassault chooses mainly the Ti-6-4 workhorse," Pachoutinsky stated in a preview of his remarks. "This allows us to rationalize our sources and to minimize qualification costs. Though our material portfolio is narrow, we can target a large range of structural parts, with appropriate optimized processes."

Dr. Michael Glavicic, senior materials engineer for international aerospace engine manufacturer Rolls Royce, will review a summary of the progress achieved in the company's "Advanced Titanium Microstructure Modeling" program, which is funded under the Metals Affordability Initiative (MAI). Glavicic states the goal of this program is to develop computational models that predict location specific microstructure and mechanical properties for wrought titanium alloys through the integration of phase field, crystal plasticity, variant selection, thermodynamic and neural net models into the commercially available finite-element software DEFORM, supported by Scientific Forming Technologies Corp., Columbus, OH.

Dr. Daira Legzdina, principal product design engineer at Phoenix-based Honeywell Aerospace, will present "Additive Manufacturing of Titanium Alloys". Additive manufacturing is a layer-by-layer technique of producing three-dimensional objects directly from a digital model without the need for hard tooling. Legzdina will spotlight three technologies are being considered for the production of titanium parts: Direct Laser Metal Sintering (DMLS); Electron Beam Melting (EBM); and Ion Fusion Formation (IFF). Legzdina's presentation will review the various technologies and discuss titanium alloy applications at Honeywell Aerospace. Additive manufacturing, according to Legzdina, has the potential for major cost savings in the aerospace industry, offering the ability to produce prototypes quickly and inexpensively, ability to produce end of life parts where tooling is no longer available.

Eric J. Fodran, Ph.D., materials and process engineer, Northrop Grumman, Advanced Materials and Processes, Falls Church, VA will discuss Electron Beam (E-Beam) metallic Additive Manufacturing (AM) of Ti-6Al-4V alloy providing a unique opportunity to meet the demands of accelerating production needs by supplying a rapid, cost-effective means of fabricating metallic components that are otherwise cycle time intensive and costly to fabricate.

It's not too late to register for TITANIUM 2012 in Atlanta October 7-10th. Visit http://www.titanium.org for Registration.

Contact: Jennifer Simpson, Executive DirectorDenver, Colorado USA1-303-404-2221 Telephone1-303-404-9111 Facsimileconference@titanium.org Email

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TITANIUM 2012 Aerospace Materials & Processes Represented By Boeing, Dassault Aviation, Honeywell, Rolls Royce ...

AMAC Aerospace Further Expands its Maintenance Capabilities on Large Jets

AMAC Aerospace, the Swiss-based provider of corporate aviation maintenance and completion services, has been granted Boeing B747-400 and B747-8 series Part 145 approval with immediate effect. Base and line maintenance services on these types can now be provided to all AMAC customers, with no restrictions.

The news of the Boeing approvals comes hot on the heels of AMAC Aerospace gaining its European EASA Part 145 approval to undertake heavy base maintenance on the Boeing 777 Series (announced this June) and Airbus A330 and A340 Series (announced earlier this month). The company can now accept scheduled and unscheduled maintenance activities for airframe and powerplants. In addition, also announced earlier in September, AMAC Aerospace Basel has received UAE CAMO approval, making it authorised to provide Continuous Airworthiness Management services on UAE registered aircraft. Customers operating aircraft in this region can now take advantage of AMAC Aerospaces expert aviation management know-how and extensive maintenance services.

AMAC Aerospace continues to perform all major inspections including repairs and modifications, delivery of Original Equipment Manufacturer (OEM) Customer Bulletins (CB) Service Bulletins (SB) and Airworthiness directive (AD) avionic repairs, upgrades and other installation undertakings, adding to the companys extensive maintenance service capabilities.

About AMAC Aerospace

AMAC Aerospace, founded four years ago, is headed by Executive Chairman & Group CEO Kadri Muhhidin. The company boasts a 600-strong workforce and an order book of US$1 billion plus. Its business is split 50:50 between VIP completions and maintenance work and its extensive hangarage facilities in Basel, Switzerland have the capability to accommodate four wide-body and four single-aisle large jets, plus lighter business jet types. AMAC opened a third new wide body hangar in Basel in September, paving the way for heavy jet maintenance to commence next year.

http://www.amacaerospace.com

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AMAC Aerospace Further Expands its Maintenance Capabilities on Large Jets

Canadian aerospace sector expected to get boost from higher airline profits

MONTREAL - Canada's aerospace sector stands to get a boost from an international airlines group's improving industry outlook, with profits expected to reach US$4.1 billion this year and US$7.5 billion in 2013.

The International Air Transport Association on Monday raised its forecast for 2012 from US$3 billion, saying passenger numbers so far this year were robust.

"Airlines are keeping their heads above water better than we expected," IATA Chief Executive Tony Tyler told reporters in Berlin.

But he noted that profits this year will still be less than half the US$8.4 billion that the industry earned in 2011.

Tyler blamed Europe's economic crisis, oil prices averaging US$110 a barrel, weak cargo demand and low business confidence for the slowdown.

A profit of US$4.1 billion on industry revenues of US$636 billion equates to a margin of just 0.6 per cent, up from 0.5 per cent in the prior forecast, Tyler noted.

Benoit Poirier of Desjardins Capital Markets said the improved profit forecast next year is positive for Canadian-based aerospace companies such as Bombardier (TSX:BBD.B), CAE Inc. (TSX:CAE), Transat A.T. (TSX:TRAZ.B) and Heroux-Devtek (TSX:TRZ.B) since profitability is typically linked to aircraft orders.

"We believe the street will see the upward revision to IATAs 2012 outlook and the solid improvement expected for 2013 as a positive surprise," he wrote in a report.

Poirier said the slightly higher forecasted profit margins demonstrates the considerable improvement in the performance of airlines in a challenging environment.

In the past, slowing demand and increasing aircraft deliveries resulted in falling passenger load factors and aircraft utilization. This time, however, airlines have kept those numbers high.

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Canadian aerospace sector expected to get boost from higher airline profits

Potential new class of drugs blocks nerve cell death

Public release date: 1-Oct-2012 [ | E-mail | Share ]

Contact: Jennifer Brown jennifer-l-brown@uiowa.edu 319-356-7124 University of Iowa Health Care

Diseases that progressively destroy nerve cells in the brain or spinal cord, such as Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), are devastating conditions with no cures.

Now, a team that includes a University of Iowa researcher has identified a new class of small molecules, called the P7C3 series, which block cell death in animal models of these forms of neurodegenerative disease. The P7C3 series could be a starting point for developing drugs that might help treat patients with these diseases. These findings are reported in two new studies published the week of Oct. 1 in PNAS Early Edition.

"We believe that our strategy for identifying and testing these molecules in animal models of disease gives us a rational way to develop a new class of neuroprotective drugs, for which there is a great, unmet need," says Andrew Pieper, M.D., Ph.D., associate professor of psychiatry at the UI Carver College of Medicine, and senior author of the two studies.

About six years ago, Pieper, then at the University of Texas Southwestern Medical Center, and his colleagues screened thousands of compounds in living mice in search of small, drug-like molecules that could boost production of neurons in a region of the brain called the hippocampus. They found one compound that appeared to be particularly successful and called it P7C3.

"We were interested in the hippocampus because new neurons are born there every day. But, this neurogenesis is dampened by certain diseases and also by normal aging," Pieper explains. "We were looking for small drug-like molecules that might enhance production of new neurons and help maintain proper functioning in the hippocampus."

However, when the researchers looked more closely at P7C3, they found that it worked by protecting the newborn neurons from cell death. That finding prompted them to ask whether P7C3 might also protect existing, mature neurons in other regions of the nervous system from dying as well, as occurs in neurodegenerative disease.

Using mouse and worm models of PD and a mouse model of ALS, the research team has now shown that P7C3 and a related, more active compound, P7C3A20, do in fact potently protect the neurons that normally are destroyed by these diseases. Their studies also showed that protection of the neurons correlates with improvement of some disease symptoms, including maintaining normal movement in PD worms, and coordination and strength in ALS mice.

Of mice and worms

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Potential new class of drugs blocks nerve cell death

Amarantus BioSciences Announces Landmark MANF Genomics Publication

SUNNYVALE, Calif., Oct. 1, 2012 /PRNewswire/ -- Amarantus BioSciences, Inc. (AMBS), a biotechnology company developing new treatments for brain-related disorders including Parkinson's disease and Traumatic Brain Injuries (TBI) centered on its proprietary anti-apoptotic therapeutic protein known as MANF, today announced the publication of a landmark research paper on MANF, Amarantus' lead development program. The studies were conducted at the University of Helsinki, a research institution based in Helsinki, Finland, performing groundbreaking neuroscience research based in its' Department of Biosciences and Institute of Biotechnology. This research paper, published by Palgi et al., from Dr. Tapio Heino's laboratory at the University of Helsinki in the peer-reviewed journal BMC Genomics is entitled "Gene expression analysis of Drosophila Manf mutants reveals perturbations in membrane traffic and major metabolic changes," in which researchers describe the critical role MANF plays in the endoplasmic reticulum, the unfolded protein response (UPR), and dopaminergic neurons which are affected by Parkinson's Disease. http://www.ncbi.nlm.nih.gov/pubmed/22494833.

"This publication marks a significant advancement in our understanding of how the MANF molecule works in improving overall cellular function," said Dr. John W. Commissiong, Founder & Chief Scientist at Amarantus. "This could be very significant as the MANF Program is advanced for Parkinson's disease"

The MANF-family (MANF and CDNF) of proteins are remarkably conserved in evolution in multicellular organisms. Previous studies in Dr. Heino's laboratory carried out by Palgi et al. demonstrate that fruit fly, Drosophila melanogaster, Manf (DmMANF) is a true orthologue to mammalian MANF, meaning that the proteins have similar biological functions in the two systems. This was most clearly demonstrated by the observation that the lethal effects of the absence of DmMANF observed in Manf mutant flies are fully rescued by human MANF (hMANF). This gene orthology makes Drosophila a powerful genetic model that can be used to study MANF signaling pathways. Furthermore, DmMANF is specifically required for the maintenance of dopaminergic neurites because in Manf mutant embryos and larvae, dopaminergic neurites degenerate and dopamine levels are extremely low. Still, despite these important observations, little is known about the mechanism of action, and about the molecules that interact with the MANF/CDNF proteins.

Dr. Heino's research group has performed an extensive microarray analyses and report interesting genome-wide differences in gene expression between wild type flies, Manf mutant flies, and flies overexpressing Manf. The data obtained from functional annotation clustering, which provides information about biological pathways influenced by these genetic differences, revealed statistically significant enrichment of genes related to metabolism and membrane transport. The observed changes at the gene expression level were further supported by ultrastructural studies of the mutants, which revealed accumulation of vesicles and a structurally disorganized endoplasmic reticulum (ER). Altogether more than 40% of the known Drosophila genes related to the ER and the unfolded protein response (UPR) showed altered expression levels in the mutants. The researchers were also able to demonstrate that lack of DmMANF results in activation of UPR in vivo. Overexpression of DmMANF resulted in upregulation of genes involved in oxidation reduction, an important process that protects dopamine neurons from oxidative stress. Thus, the results support the previously reported findings in mammalian cells that upregulation of MANF is important in the UPR and is protective for the cell. The UPR has been implicated in several human neurodegenerative diseases.

Dr. Mari Palgi, the lead author on the study observed that, "Additionally, this microarray study in Drosophila revealed several other genes and processes implicated in the pathology of Parkinson's disease such as mitochondrial Htra2 and DJ-1, oxidative phosphorylation, and protein ubiquitination. Interestingly, despite the very low dopamine levels in Manf mutants, the genes involved in dopamine synthesis and metabolism showed clear upregulation."

About Amarantus BioSciences, Inc.

Amarantus BioSciences, Inc. is a development-stage biotechnology company founded in January 2008. The Company has a focus on developing certain biologics surrounding the intellectual property and proprietary technologies it owns to treat and/or diagnose Parkinson's disease, Traumatic Brain Injury and other human diseases. The Company owns the intellectual property rights to a therapeutic protein known as Mesencephalic-Astrocyte-derived Neurotrophic Factor ("MANF") and is developing MANF-based products as treatments for brain disorders. The Company also is a Founding Member of the Coalition for Concussion Treatment (#C4CT), a movement initiated in collaboration with Brewer Sports International seeking to raise awareness of new treatments in development for concussions and nervous-system disorders. For further information please visit http://www.Amarantus.com.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements include, but are not limited to, statements about the possible benefits of MANF therapeutic applications and/or advantages presented by Amarantus' PhenoGuard technology, as well as statements about expectations, plans and prospects of the development of Amarantus' new product candidates. These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including the risks that the anticipated benefits of the therapeutic drug candidates or discovery platforms, as well as the risks, uncertainties and assumptions relating to the development of Amarantus' new product candidates, including those identified under "Risk Factors" in Amarantus' most recently filed Annual Report on Form 10-K and Quarterly Report on Form 10-Q and in other filings Amarantus periodically makes with the SEC. Actual results may differ materially from those contemplated by these forward-looking statements Amarantus does not undertake to update any of these forward-looking statements to reflect a change in its views or events or circumstances that occur after the date of this presentation.

MEDIA CONTACTS Amarantus BioSciences, Inc. Gerald E. Commissiong 408-737-2734 pr@amarantus.com

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Amarantus BioSciences Announces Landmark MANF Genomics Publication

Researchers define 2 categories of multiple sclerosis patients

Public release date: 26-Sep-2012 [ | E-mail | Share ]

Contact: Marjorie Montemayor-Quellenberg mmontemayor-quellenberg@partners.org 617-534-2208 Brigham and Women's Hospital

BOSTON, MAThere are approximately 400,000 people in the United States with multiple sclerosis. Worldwide, the number jumps to more than 2.1 million people. Rather than a one-size-fits-all approach to treating the millions with multiple sclerosis, what if doctors could categorize patients to create more personalized treatments? A new study by researchers at Brigham and Women's Hospital (BWH) may one day make this idea a reality in the fight against the debilitating autoimmune disease.

A research team led by Philip De Jager, MD, PhD, BWH Department of Neurology, senior study author, has found a way to distinguish patients with multiple sclerosis into two meaningful subsets. The ability to categorize patients with multiple sclerosis may open new doors for treatment development.

The study will be electronically published on September 26, 2012 in Science Translational Medicine.

"Our results suggest that we can divide the multiple sclerosis patient population into groups that have different levels of disease activity," said De Jager. "These results motivate us to improve these distinctions with further research so that we may reach our goal of identifying the best treatment for each individual who has multiple sclerosis."

De Jager and his team extracted RNAkey molecules involved in making proteins from the instructions found in the DNA sequencefrom blood cells of patients with multiple sclerosis. After analyzing the samples, they found distinct sets of RNA molecules among the patient samples. These unique sets formed a transcriptional signature that distinguished two sets of multiple sclerosis patientsMSa patients and MSb patientswith those in the MSa group having a higher risk for future multiple sclerosis relapse.

According to the researchers, knowing the category a person with multiple sclerosis is in may help doctors make more informed treatment decisions. For instance, since a patient who falls into the MSa category is more likely to experience relapse, her doctor may consider a stronger treatment for the patient.

In light of the discovery, the researchers remain cautious about the findings.

"Our study is an important step towards the goal of personalized medicine in MS, but much work remains to be done to understand under which circumstance and in combination with which other information this transcriptional signature may become useful in a clinical setting," said De Jager.

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Researchers define 2 categories of multiple sclerosis patients

Lewy Body Dementia Association (LBDA) Is Making October “A Month to Remember”

Newswise ATLANTA (October 1, 2012) The Lewy Body Dementia Association (LBDA) announces today is the first day of nationwide October Lewy body dementia awareness month, A Month To Remember. LBDA invited volunteers to join the awareness movement by Standing Strong with LBDA to build awareness for Lewy body dementia in their communities all month long. The LBD Awareness Movement is a national, grass roots effort to increase LBD awareness in the general public and medical profession. Participants in the movement are getting involved with LBDA in several ways to make Lewy body dementia (LBD) become a household word, from distributing materials in their community and to local physicians offices, to organizing outreach or community fundraising events.

Lewy body dementia (LBD) affects an estimated 1.3 million individuals and their families in the United States. It is currently widely underdiagnosed because LBD symptoms can closely resemble other more commonly known diseases like Alzheimers and Parkinsons. Many doctors or other medical professionals still are not familiar with LBD. Early diagnosis allows for important early treatment that may extend quality of life.

Given the growing population of older Americans, at some point in your life LBD will likely affect someone you know, said Angela Herron, President of LBDAs Board of Directors. The general public, and far too many primary care doctors and nurses, have never heard of LBD. In addition to trying to manage a very difficult disease, LBD families find themselves in the unanticipated role of educator and advocate.

These are just a few of the outstanding efforts around the country: Karen F. of Allentown, PA has 8 outreach events and media activities in October Rachael V. and Samantha L. are organizing the 1st Annual LBD Walk for Awareness in Abilene, TX on Oct. 20! Karen M. organized the Giddy-Up for Gary 5K in Omaha, NE on Oct. 12! Sue Ellen J. is doing an outreach event, delivering posters and materials to physicians and getting the word out and the PSAs to her local media in Austin, TX!

Check out LBDAs online calendar for all of the events for October Awareness Month!

LBDA is also encouraging Awareness Movement participants throughout the country to engage with each other locally by joining a Hub of Hope in their community. LBDA Hubs of Hope provide opportunities to connect LBD families and friends in local areas to build a network of resources for caregivers and people with LBD, as well as engage them in social and educational programs about LBD. To join LBDAs awareness movement, A Month To Remember, and for more information please visit http://www.lbda.org/go/awareness.

The Lewy Body Dementia Association The Lewy Body Dementia Association (LBDA) is a 501(c)(3) nonprofit organization dedicated to raising awareness of the Lewy body dementias (LBD), supporting patients, their families and caregivers, and promoting scientific advances. Through outreach, education and research, LBDA supports those affected by Lewy body dementias. To learn more about LBD and LBDA please visit http://www.lbda.org.

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Lewy Body Dementia Association (LBDA) Is Making October "A Month to Remember"

Lewy Body Dementia Association (LBDA) Is Making October "A Month to Remember"

Newswise ATLANTA (October 1, 2012) The Lewy Body Dementia Association (LBDA) announces today is the first day of nationwide October Lewy body dementia awareness month, A Month To Remember. LBDA invited volunteers to join the awareness movement by Standing Strong with LBDA to build awareness for Lewy body dementia in their communities all month long. The LBD Awareness Movement is a national, grass roots effort to increase LBD awareness in the general public and medical profession. Participants in the movement are getting involved with LBDA in several ways to make Lewy body dementia (LBD) become a household word, from distributing materials in their community and to local physicians offices, to organizing outreach or community fundraising events.

Lewy body dementia (LBD) affects an estimated 1.3 million individuals and their families in the United States. It is currently widely underdiagnosed because LBD symptoms can closely resemble other more commonly known diseases like Alzheimers and Parkinsons. Many doctors or other medical professionals still are not familiar with LBD. Early diagnosis allows for important early treatment that may extend quality of life.

Given the growing population of older Americans, at some point in your life LBD will likely affect someone you know, said Angela Herron, President of LBDAs Board of Directors. The general public, and far too many primary care doctors and nurses, have never heard of LBD. In addition to trying to manage a very difficult disease, LBD families find themselves in the unanticipated role of educator and advocate.

These are just a few of the outstanding efforts around the country: Karen F. of Allentown, PA has 8 outreach events and media activities in October Rachael V. and Samantha L. are organizing the 1st Annual LBD Walk for Awareness in Abilene, TX on Oct. 20! Karen M. organized the Giddy-Up for Gary 5K in Omaha, NE on Oct. 12! Sue Ellen J. is doing an outreach event, delivering posters and materials to physicians and getting the word out and the PSAs to her local media in Austin, TX!

Check out LBDAs online calendar for all of the events for October Awareness Month!

LBDA is also encouraging Awareness Movement participants throughout the country to engage with each other locally by joining a Hub of Hope in their community. LBDA Hubs of Hope provide opportunities to connect LBD families and friends in local areas to build a network of resources for caregivers and people with LBD, as well as engage them in social and educational programs about LBD. To join LBDAs awareness movement, A Month To Remember, and for more information please visit http://www.lbda.org/go/awareness.

The Lewy Body Dementia Association The Lewy Body Dementia Association (LBDA) is a 501(c)(3) nonprofit organization dedicated to raising awareness of the Lewy body dementias (LBD), supporting patients, their families and caregivers, and promoting scientific advances. Through outreach, education and research, LBDA supports those affected by Lewy body dementias. To learn more about LBD and LBDA please visit http://www.lbda.org.

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Lewy Body Dementia Association (LBDA) Is Making October "A Month to Remember"

Dementia ‘night camp’ gives caregivers a rest

Jim Fitzgerald / AP

Victor Rivera dances with a dementia patient Sept. 20 at the Hebrew Home at Riverdale in the Bronx borough of New York. The Hebrew Home has a program that provides care and activity overnight for dementia victims with sleep problems.

By JIM FITZGERALD, AP

NEW YORKJust after 10 p.m., when most people their age are going to sleep, a group of elderly folks suffering from dementia are just getting started, dancing and shaking tambourines and maracas in a raucous version of "La Bamba."

"It's a party," says an 81-year-old woman, among dozens of patients brought to a Bronx nursing home every night for a structured series of singalongs, crafts and therapy sessions that lasts until dawn.

The program, which appears to be rare, is kind of a "night camp" for dementia victims who don't sleep at night or tend to wake up agitated or become frightened or disoriented by the fall of darkness.

It's meant to provide care and activity lots of activity to fill the wee hours for people with Alzheimer's and similar diseases who live at home. And it's meant to provide their caregivers usually a son or daughter with a treasured night's sleep.

"Without this program, my father would be lost, and I would be crazy," said Robert Garcia, whose 82-year-old father, Felix, is in the program at the Hebrew Home at Riverdale called ElderServe at Night. "He doesn't sleep. At night he's wide awake, and he needs activity."

Garcia, who lives in a Bronx apartment with his wife and three of their children, said that before his father went into the program he would wake up in the night, loudly, and keep everyone else from sleeping.

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Dementia 'night camp' gives caregivers a rest

Dementia 'night camp' gives caregivers a rest

Jim Fitzgerald / AP

Victor Rivera dances with a dementia patient Sept. 20 at the Hebrew Home at Riverdale in the Bronx borough of New York. The Hebrew Home has a program that provides care and activity overnight for dementia victims with sleep problems.

By JIM FITZGERALD, AP

NEW YORKJust after 10 p.m., when most people their age are going to sleep, a group of elderly folks suffering from dementia are just getting started, dancing and shaking tambourines and maracas in a raucous version of "La Bamba."

"It's a party," says an 81-year-old woman, among dozens of patients brought to a Bronx nursing home every night for a structured series of singalongs, crafts and therapy sessions that lasts until dawn.

The program, which appears to be rare, is kind of a "night camp" for dementia victims who don't sleep at night or tend to wake up agitated or become frightened or disoriented by the fall of darkness.

It's meant to provide care and activity lots of activity to fill the wee hours for people with Alzheimer's and similar diseases who live at home. And it's meant to provide their caregivers usually a son or daughter with a treasured night's sleep.

"Without this program, my father would be lost, and I would be crazy," said Robert Garcia, whose 82-year-old father, Felix, is in the program at the Hebrew Home at Riverdale called ElderServe at Night. "He doesn't sleep. At night he's wide awake, and he needs activity."

Garcia, who lives in a Bronx apartment with his wife and three of their children, said that before his father went into the program he would wake up in the night, loudly, and keep everyone else from sleeping.

See the rest here:
Dementia 'night camp' gives caregivers a rest

Overnight dementia care gives caregivers some rest

NEW YORK (AP) Just after 10 p.m., when most people their age are going to sleep, a group of elderly folks suffering from dementia are just getting started, dancing and shaking tambourines and maracas in a raucous version of "La Bamba."

"It's a party," says an 81-year-old woman, among dozens of patients brought to a Bronx nursing home every night for a structured series of singalongs, crafts and therapy sessions that lasts until dawn.

The program, which appears to be rare, is kind of a "night camp" for dementia victims who don't sleep at night or tend to wake up agitated or become frightened or disoriented by the fall of darkness.

It's meant to provide care and activity lots of activity to fill the wee hours for people with Alzheimer's and similar diseases who live at home. And it's meant to provide their caregivers usually a son or daughter with a treasured night's sleep.

"Without this program, my father would be lost, and I would be crazy," said Robert Garcia, whose 82-year-old father, Felix, is in the program at the Hebrew Home at Riverdale called ElderServe at Night. "He doesn't sleep. At night he's wide awake, and he needs activity."

Garcia, who lives in a Bronx apartment with his wife and three of their children, said that before his father went into the program he would wake up in the night, loudly, and keep everyone else from sleeping.

"We would all wake up, and my daughter would ask, 'Why is Grandpa screaming? Why is he so grumpy?'" Garcia said.

"Now he comes home in the morning, shows me his drawings, tells me what they did all night."

While many nursing homes offer temporary "respite care" so caregivers can catch up on sleep or go on vacation, the overnight-only program at the Hebrew Home fills a niche.

But costs are high, and such programs are rare. An official at the Alzheimer's Association said she knew of no other.

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Overnight dementia care gives caregivers some rest

Overnight dementia ‘camp’ allows caregivers rest

NEW YORK (AP) Just after 10 p.m., when most people their age are going to sleep, a group of elderly folks suffering from dementia are just getting started, dancing and shaking tambourines and maracas in a raucous version of "La Bamba."

"It's a party," says an 81-year-old woman, among dozens of patients brought to a Bronx nursing home every night for a structured series of singalongs, crafts and therapy sessions that lasts until dawn.

The program, which appears to be rare, is kind of a "night camp" for dementia victims who don't sleep at night or tend to wake up agitated or become frightened or disoriented by the fall of darkness.

It's meant to provide care and activity lots of activity to fill the wee hours for people with Alzheimer's and similar diseases who live at home. And it's meant to provide their caregivers usually a son or daughter with a treasured night's sleep.

"Without this program, my father would be lost, and I would be crazy," said Robert Garcia, whose 82-year-old father, Felix, is in the program at the Hebrew Home at Riverdale called ElderServe at Night. "He doesn't sleep. At night he's wide awake, and he needs activity."

Garcia, who lives in a Bronx apartment with his wife and three of their children, said that before his father went into the program he would wake up in the night, loudly, and keep everyone else from sleeping.

"We would all wake up, and my daughter would ask, 'Why is Grandpa screaming? Why is he so grumpy?'" Garcia said.

"Now he comes home in the morning, shows me his drawings, tells me what they did all night."

While many nursing homes offer temporary "respite care" so caregivers can catch up on sleep or go on vacation, the overnight-only program at the Hebrew Home fills a niche.

But costs are high, and such programs are rare. An official at the Alzheimer's Association said she knew of no other.

Excerpt from:
Overnight dementia 'camp' allows caregivers rest

Overnight dementia 'camp' allows caregivers rest

NEW YORK (AP) Just after 10 p.m., when most people their age are going to sleep, a group of elderly folks suffering from dementia are just getting started, dancing and shaking tambourines and maracas in a raucous version of "La Bamba."

"It's a party," says an 81-year-old woman, among dozens of patients brought to a Bronx nursing home every night for a structured series of singalongs, crafts and therapy sessions that lasts until dawn.

The program, which appears to be rare, is kind of a "night camp" for dementia victims who don't sleep at night or tend to wake up agitated or become frightened or disoriented by the fall of darkness.

It's meant to provide care and activity lots of activity to fill the wee hours for people with Alzheimer's and similar diseases who live at home. And it's meant to provide their caregivers usually a son or daughter with a treasured night's sleep.

"Without this program, my father would be lost, and I would be crazy," said Robert Garcia, whose 82-year-old father, Felix, is in the program at the Hebrew Home at Riverdale called ElderServe at Night. "He doesn't sleep. At night he's wide awake, and he needs activity."

Garcia, who lives in a Bronx apartment with his wife and three of their children, said that before his father went into the program he would wake up in the night, loudly, and keep everyone else from sleeping.

"We would all wake up, and my daughter would ask, 'Why is Grandpa screaming? Why is he so grumpy?'" Garcia said.

"Now he comes home in the morning, shows me his drawings, tells me what they did all night."

While many nursing homes offer temporary "respite care" so caregivers can catch up on sleep or go on vacation, the overnight-only program at the Hebrew Home fills a niche.

But costs are high, and such programs are rare. An official at the Alzheimer's Association said she knew of no other.

Excerpt from:
Overnight dementia 'camp' allows caregivers rest

Autism Center receives gift from Hussman foundation

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30 September 2012 By Jonathan Munshaw, News Editor One Comment

Abby Murphy/ The Towerlight

After receiving a $1.25 million gift from the John P. Hussman Foundation, the Towson University Center for Adults with Autism has constructed a life skills center inside the Towson City Center. The skills center includes a fully-functional kitchen, living room, bedroom and bathroom that students on the spectrum of autism use to gain social and life skills that are often impeded by autism. The autism center used to only exist in a 150 square-foot space, Ray Stinar administrative director for the Center for Adults with Autism said. Last year, we had a student who would not come out of his room for eight hours, because he couldnt decide what shirt to put on, Stinar said. For us, thats not that big of a deal, its something that we do every day, but for him, it was a huge task and eventually he got it, but those are the types of things that adults on the spectrum need help with. With help from the Baltimore County Government as well as the gift from the Hussman Foundation, the center was able to move into the Towson City Center and open several classrooms, including an animation lab and the life skills center. In addition to the faculty members at the center, student mentors also assist the students and adults on the spectrum. Since weve moved, weve seen a huge increase in interest to volunteer with us, Rhonda Greenhaw, director of the center for adults with autism, said. Its really exciting because we keep expanding every year. Greenhaw said that the students and adults are learning practical skills and that in the near future, some of the students with autism will also work in dining halls. We just really hope that students can learn these skills so they have something to contribute, and could hopefully turn these skills into a job, she said. The gift came out of a mutual understanding between the University and the Hussman Foundation, Greenhaw said. [The Hussman Foundation] is the largest funder of autism research, so it was a huge vote of confidence to us because they are putting their faith in our program, she said. The center has a lease in the City Center for the next 10 years, according to Greenhaw, and staff wants even more students to volunteer. Autism is really an internal experience, she said. Thats why its important to have a program like this, because it allows the adults on the spectrum to work these things out for themselves. We want them to build up these experiences, and take them outside of the center and revolutionize the community.

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Autism Center receives gift from Hussman foundation

Autism on the Rise and a Young Mother’s Struggle

Olga Chinchilla, then 18 and pregnant, sat glued to the television screen, intrigued by a report on a developmental disorder that impairs social skills.

"I remember sitting there and had never heard about the disability before," said Chinchilla. "Little did I know that in three years my son Anakin was going to be diagnosed with autism." Initially, she said she ignored signs that her son potentially had autism a developmental disorder that is exhibited in impaired comprehension, language barriers, and repetitive behaviors because she was in shock and did not quite know what to expect. "I was the one in denial," she said. Her family's reaction did not help. "Being Hispanic, the typical thing they tell you is that 'it's okay, he's a boy. Boys develop a lot slower than girls do.'"

But there was something alarming and oddly different about Anakin's behavior. At 12 months, he could not walk or talk. There were many times when Anakin could not even look his mother directly in the eyes. He did not like it when anyone touched him and he would often slam doors and spin objects in a repetitive manner warning signs that eventually prompted Chinchilla to seek help from a pediatrician, a health center and then a psychologist.

Chinchilla, now 24, has transitioned from initial disbelief and denial of her son's diagnosis, to struggling as a single mother to find the right resources for Anakin and later advocating and educating others about the rights of families of children with developmental disabilities in the Alhambra area.

Anakin was diagnosed with autism at 22 months and later began receiving funds for ABA therapies at age four at Alhambra's East Los Angeles Regional Center (ELARC), one of 21 resource and service centers in the state of California catering to individuals with developmental disabilities.

Gloria Wong, executive director of ELARC says that 38 percent of their clients are diagnosed with autism, the second largest diagnosis at the center, after mental retardation. Nationally, autism cases have spiked in recent years. According to the Centers for Disease Control and Prevention, 1 in 88 children have been diagnosed with an autism spectrum disorder, a 23 percent increase from CDC's 2009 report. Additionally, more children are being diagnosed at an earlier age and the disability seems much more prevalent in boys than girls.

"There is really an unknown reason for that spike that continues to grow, but there have been studies in terms of what is spiking the ongoing growth in California," said Wong.

Olga Chinchilla and her son Anakin. Shortly after her son's diagnosis, Chinchilla recalls struggling to work as a full-time medical assistant while providing Anakin the special care he needed.

"I was in Rosemead at one point, and I tried two different daycares within a week," Chinchilla said. "I would get off work and get there crying....You try to make a living for your child, you go to work but the whole day, you wonder, 'how's my kid?'"

Chinchilla realized that Anakin needed more than just regular daycare service; he needed a place that catered to children with developmental disabilities. But the search for special daycares was a challenge, and as a single mother, she was not able to afford the cost many of which were well over $30,000 a year.

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Autism on the Rise and a Young Mother's Struggle

Autism on the Rise and a Young Mother's Struggle

Olga Chinchilla, then 18 and pregnant, sat glued to the television screen, intrigued by a report on a developmental disorder that impairs social skills.

"I remember sitting there and had never heard about the disability before," said Chinchilla. "Little did I know that in three years my son Anakin was going to be diagnosed with autism." Initially, she said she ignored signs that her son potentially had autism a developmental disorder that is exhibited in impaired comprehension, language barriers, and repetitive behaviors because she was in shock and did not quite know what to expect. "I was the one in denial," she said. Her family's reaction did not help. "Being Hispanic, the typical thing they tell you is that 'it's okay, he's a boy. Boys develop a lot slower than girls do.'"

But there was something alarming and oddly different about Anakin's behavior. At 12 months, he could not walk or talk. There were many times when Anakin could not even look his mother directly in the eyes. He did not like it when anyone touched him and he would often slam doors and spin objects in a repetitive manner warning signs that eventually prompted Chinchilla to seek help from a pediatrician, a health center and then a psychologist.

Chinchilla, now 24, has transitioned from initial disbelief and denial of her son's diagnosis, to struggling as a single mother to find the right resources for Anakin and later advocating and educating others about the rights of families of children with developmental disabilities in the Alhambra area.

Anakin was diagnosed with autism at 22 months and later began receiving funds for ABA therapies at age four at Alhambra's East Los Angeles Regional Center (ELARC), one of 21 resource and service centers in the state of California catering to individuals with developmental disabilities.

Gloria Wong, executive director of ELARC says that 38 percent of their clients are diagnosed with autism, the second largest diagnosis at the center, after mental retardation. Nationally, autism cases have spiked in recent years. According to the Centers for Disease Control and Prevention, 1 in 88 children have been diagnosed with an autism spectrum disorder, a 23 percent increase from CDC's 2009 report. Additionally, more children are being diagnosed at an earlier age and the disability seems much more prevalent in boys than girls.

"There is really an unknown reason for that spike that continues to grow, but there have been studies in terms of what is spiking the ongoing growth in California," said Wong.

Olga Chinchilla and her son Anakin. Shortly after her son's diagnosis, Chinchilla recalls struggling to work as a full-time medical assistant while providing Anakin the special care he needed.

"I was in Rosemead at one point, and I tried two different daycares within a week," Chinchilla said. "I would get off work and get there crying....You try to make a living for your child, you go to work but the whole day, you wonder, 'how's my kid?'"

Chinchilla realized that Anakin needed more than just regular daycare service; he needed a place that catered to children with developmental disabilities. But the search for special daycares was a challenge, and as a single mother, she was not able to afford the cost many of which were well over $30,000 a year.

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Autism on the Rise and a Young Mother's Struggle

New Autism Care Rules Require Some To Pay For Once Free Services

PITTSBURGH (KDKA) Parents of children with autism are protesting new rules that took effect today in Pennsylvania, which will require parents at certain income levels to partially pay for services that used to be free.

Nicki Gratton, of Plum, is one of them. She has three children. Jeremy has cerebral palsy and Riley has pervasive developmental disorder, which is a type of autism.

Gratton told KDKA-TVs Dr. Maria Simbra that three home visits per week to help her with her childrens behavior issues have been a God-send.

The Pennsylvania Department of Public Welfare used to provide these services at no charge for 48,000 children with mental and physical disabilities.

However, families earning more than $45,000 a year will now have to pay co-pays ranging from $1 to $3 per service. Items such as medical equipment, physical, occupational and speech therapy and outpatient services are exempt.

Cathy Hughes with Family Behavioral Resources, which provides services now subject to co-pays, said the change could be devastating.

Im taking calls and e-mails night and day from families that are going to pay between $400 to $700 a month and theyre going to have to make huge sacrifices, Hughes said.

She also worries about her agency and others having to lay off staff, or parents quitting their jobs so they fall under the poverty level and qualify for free services.

Welfare Secretary Gary Anderson said adding the co-pays was necessary to keep services afloat.

Were growing in the department at eight percent a year, and state revenues are only growing at two percent. In order for us to be able to sustain it for the long haul, the families need to start to pay something for their health care, said Anderson.

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New Autism Care Rules Require Some To Pay For Once Free Services

Understanding aging: Stem cell dysfunction links cancer and aging

ScienceDaily (Oct. 1, 2012) Aging is a complex biological process whereby the functional capacity of the body diminishes with time, ultimately leading to the death of the individual. However, aging is also associated with the onset of many diseases, including cancer, which is often called a "disease of aging." While aging has major effects on the individual, it also represents a significant burden on society as a major healthcare cost. Therefore, it is of chief importance to understand the normal process of aging to help improve not only the lifespan of individuals, but also their healthspan; in other words, to enable people to live longer, healthier lives.

Despite significant worldwide research, the causes of aging remain poorly understood. In particular, why the body undergoes a functional decline over the course of time is not entirely clear. Now, a new study from researchers at the CRG has uncovered a significant clue in understanding how aging may occur, and how this may promote the development of diseases such as cancer.

In this study, the researchers studied the skin of young and old mice, as the skin is one of the most obvious tissues to undergo aging. Indeed many of the visible features of aging are the result of skin aging, including loss of hair growth, wrinkling and thinning of the skin and a reduced wound-healing ability.

In the skin, as in the rest of the body, the tissue is constantly in a state of turnover, replenishing itself by replacing dead and damaged cells with new healthy ones. To achieve this, each tissue relies on populations of specialized cells known as stem cells. "These cells are unique in their ability, as they are able to grow and differentiate into all the other different cells types in the tissue, as well as tolerating stress and damage better than non-stem cells. This process of rejuvenation and renewal is something that was thought to occur all throughout life" says Jason Doles, the first author on the study and a postdoctoral researcher at the CRG.

In this work, the researchers have studied skin stem cells during the aging process to see if changes in stem cell function might contribute to aging. Their major finding is that during the aging process, skin stem cells actually lose their ability to function properly. "We have discovered that major changes occur in these stem cells during aging, whereby stem cells exhibit impaired growth in older animals as compared to their more youthful counterparts. We also found that the aged stem cells are not able to tolerate stress as well as young stem cells, strongly supporting the idea that changes in stem cell function might actually drive the aging process" says Bill Keyes, group leader of the Mechanisms of Cancer and Aging lab at the CRG and lead author of the study.

The report goes further, uncovering novel processes driving skin stem cell aging, and linking the aging process with diseases such as cancer. In fact, a recent study from the same group, demonstrated that these same stem cells become deregulated during the development of squamous cell carcinoma, a deadly type of skin cancer. The current study performed high-throughput profiling of the aging stem cells and identified a likely cause of the loss of function during aging. They demonstrated that during normal aging, the entire skin changes and produces many different proteins that mediate inflammation, and that it is the abnormal production of these inflammatory-mediators that contributes to the decline of stem cell function. Given that the link between inflammation and the development of cancer has been long known, the current study uncovers important findings on how the two might be linked.

Altogether, these findings help to explain what is likely a major cause of the aging process and how this develops, opening the door for future studies that may help to alleviate aspects of the aging process. But in addition, with the identification of inflammation as a cause of stem cell dysfunction, the study also uncovers likely causes in the development of cancer.

The research has been funded by the Spanish Ministry for Science and Innovation and the Centre for Genomic Regulation (CRG).

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Understanding aging: Stem cell dysfunction links cancer and aging

Stem cells improve visual function in blind mice

ScienceDaily (Oct. 1, 2012) An experimental treatment for blindness, developed from a patient's skin cells, improved the vision of blind mice in a study conducted by Columbia ophthalmologists and stem cell researchers.

The findings suggest that induced pluripotent stem (iPS) cells -- which are derived from adult human skin cells but have embryonic properties -- could soon be used to restore vision in people with macular degeneration and other diseases that affect the eye's retina.

"With eye diseases, I think we're getting close to a scenario where a patient's own skin cells are used to replace retina cells destroyed by disease or degeneration," says the study's principal investigator, Stephen Tsang, MD, PhD, associate professor of ophthalmology and pathology & cell biology. "It's often said that iPS transplantation will be important in the practice of medicine in some distant future, but our paper suggests the future is almost here."

The advent of human iPS cells in 2007 was greeted with excitement from scientists who hailed the development as a way to avoid the ethical complications of embryonic stem cells and create patient-specific stem cells. Like embryonic stem cells, iPS cells can develop into any type of cell. Thousands of different iPS cell lines from patients and healthy donors have been created in the last few years, but they are almost always used in research or drug screening.

No iPS cells have been transplanted into people, but many ophthalmologists say the eye is the ideal testing ground for iPS therapies.

"The eye is a transparent and accessible part of the central nervous system, and that's a big advantage. We can put cells into the eye and monitor them every day with routine non-invasive clinical exams," Tsang says. "And in the event of serious complications, removing the eye is not a life-threatening event."

In Tsang's new preclinical iPS study, human iPS cells -- derived from the skin cells of a 53-year-old donor -- were first transformed with a cocktail of growth factors into cells in the retina that lie underneath the eye's light-sensing cells.

The primary job of the retina cells is to nourish the light-sensing cells and protect the fragile cells from excess light, heat, and cellular debris. If the retina cells die -- which happens in macular degeneration and retinitis pigmentosa -- the photoreceptor cells degenerate and the patient loses vision. Macular degeneration is a leading cause of vision loss in the elderly, and it is estimated that 30 percent of people will have some form of macular degeneration by age 75. Macular degeneration currently affects 7 million Americans and its incidence is expected to double by 2020.

In their study, the researchers injected the iPS-derived retina cells into the right eyes of 34 mice that had a genetic mutation that caused their retina cells to degenerate.

In many animals, the human cells assimilated into mouse retina without disruption and functioned as normal retina cells well into the animals' old age. Control mice that got injections of saline or inactive cells showed no improvement in retina tests.

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Stem cells improve visual function in blind mice

Houston Stem Cell Summit Announces Extraordinary Lineup of Keynote Speakers

HOUSTON, Oct. 1, 2012 /PRNewswire/ --The Houston Stem Cell Summit will host an extraordinary lineup of keynote speakers who represent the most accomplished stem cell scientists, clinicians and entrepreneurs in the United States. Joining these distinguished speakers will be Governor of Texas, Rick Perry, consistent champion of adult stem cell therapies.

(Logo: http://photos.prnewswire.com/prnh/20120831/NY66463LOGO )

The Houston Stem Cell Summit will be held October 26 27 in its namesake city and will highlight the latest therapeutic research regarding the use of adult stem and progenitor cell therapies. The Summit will also provide a forum for entrepreneurs to discuss their latest efforts to commercialize stem cell therapies, and to debate and discuss FDA and other legal and regulatory issues impacting stem cell research and commercialization.

Opening Keynote Address October 26, 2012 Arnold I. Caplan, PhD, Professor of Biology and Professor of General Medical Sciences (Oncology) Case Western Reserve University

Dr. Caplan has helped shape the direction and focus of adult stem cell research and commercialization. Virtually every adult stem cell company and literally tens of thousands of research papers are based on Dr. Caplan's original and ground breaking research. Professor Caplan is considered to be the "father" of the mesenchymal stem cell and first described this progenitor cell in his landmark paper; "Mesenchymal stem cells", Journal of Orthopaedic Research 1991;9(5):641-650. Since that foundational study, Dr. Caplan has published over 360 manuscripts and articles in peer reviewed journals. Dr. Caplan has been Chief Scientific Officer at OrthoCyte Corporation since 2010. In addition, Dr. Caplan co-founded Cell Targeting Inc. and has served as President of Skeletech, Inc. as its founder. He is the recipient of several honors and awards from the orthopedic research community. Dr. Caplan holds a Ph. D. from Johns Hopkins University Medical School and a B.S. in chemistry from the Illinois Institute of Technology.

Summit Keynote Address October 26, 2012 Texas Governor Rick Perry

Governor Perry is the 47th and current Governor of Texas. Governor Perry has long championed the role of medical technologies in building the future of not only Texas, but also the United States. In many ways, his strong advocacy on behalf of research and advanced medical technologies is one of his strongest and as yet underappreciated legacies. In addition to his service to the state of Texas, Governor Perry has also served as Chairman of the Republican Governors Association in 2008 and again in 2011. Despite a rigorous schedule, particularly in the teeth of this election season, Governor Perry has graciously made time to speak and encourage the researchers, patients, companies and physicians who form the fabric and future of the stem cell therapy community.

Texas Medical Center Keynote Address, October 27, 2012 James T. Willerson, MD

Over the course of his career, Dr. James T. Willerson has served as a medical, scientific and administrative leader for each of the major institutions that are the foundation of the Texas Medical Center. Dr. Willerson is currently President and Medical Director, Director of Cardiology Research, and Co-Director of the Cullen Cardiovascular Research Laboratories at Texas Heart Institute (THI). Dr. Willerson was appointed President-Elect of THI in 2004 and became President and Medical Director in 2008. He is also an adjunct professor of Medicine at Baylor College of Medicine and at The University of Texas MD Anderson Cancer Center. He is the former chief of Cardiology at St. Luke's Episcopal Hospital and the former chief of Medical Services at Memorial Hermann Hospital.

Dr. Willerson has served as a visiting professor and invited lecturer at more than 170 institutions.

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Houston Stem Cell Summit Announces Extraordinary Lineup of Keynote Speakers