I’ve got your missing links right here (2 April 2011) | Not Exactly Rocket Science

Egyptian cobra by Michael Ransburg

Top twelve picks

This, my friends, is how it’s done. Carl Zimmer on “The Human Lake“. If you read one post this month…

Inspired. Craig McClain draws parallels between a 1st century Germanic chieftain and a baby coral

I loved the Bronx Zoo Cobra story. It was a wonderful break from a month of depressing news. I loved this line: “The case of the missing [cobra] has yielded much interest… What It has not yielded is the snake.” I loved the @Bronxzooscobra Twitter feed, and the @Bronxcobrawife one too. I loved the exclusive interview in the NYT.

An amazing story that starts with an egg sandwich, continues with a weird bag of blue powder, and ends with mass radiation poisoning. By Sally Adee

A touching look at the people on Fukushima’s frontline. “My town is gone… My parents are still missing… I still have to work…”

Mark Peplow of Nature News visits Chernobyl. What lessons does it hold for Fukushima?

Unbeleafable! Scientists create artificial leaf, 10x more efficient than the real deal.

Bugs vs drugs: Maryn McKenna, writing about ...

Revisting Yevgeny Zamyatin’s We (1921)

Everybody knows the dystopian novels Brave New World and 1984, but few remember Yevgeny Zamyatin's seminal work, We.

The Russian Zamyatin completed We in 1921, a book that was largely written in response to the Bolshevik Revolution of 1917 and his work in the Tyne shipyards during the First World War. The result was a characteristically unique vision of the future, one that in turn spawned the satirical science fiction dystopia genre.

There's no questioning Zamyatin's influence on 21st Century writers like Aldous Huxley, George Orwell, Kurt Vonnegut and even Ayn Rand. In fact, Orwell himself said that it served as the model for 1984. Like the writers who followed him, Zamyatin took the burgeoning totalitarian and conformative elements of modern industrial society to an extreme conclusion, conveying a surveillance state that considered free will as the cause of unhappiness—and who in turn took it upon itself to control and direct the lives of its citizens.

The novel is set in the future where the protagonist, D-503, lives in the One State, an urban nation constructed almost entirely of glass and which serves as a kind of Benthamite Panopticon; the configuration allows the secret police and spies to inform on and supervise the public more easily. Society is thus portrayed as a kind of prison.

Life in this society is organized to promote maximum productive efficiency along the lines of the system advocated by the hugely influential F.W. Taylor. People march in step with each other and wear identical clothing. Names have been replaced by numbers; men have odd numbers prefixed by consonants while women have even numbers prefixed by vowels. The story itself follows the plight of D-503 as he struggles to reconcile his obligations to the state with his discovery of a nascent revolt called the Mephi.

Like 1984, the dystopian society is presided over by the Benefactor (who Orwell called Big Brother) and every hour "The Table" offers instructions to citizens (a precursor to the telescreen).

Needless to say Zamyatin's book was immediately banned in the Soviet Union. His literary position quickly deteriorated during the 1920s and he eventually fled to Paris in 1931. The novel was first published in English in 1924, but its first publication in the Soviet Union had to wait until 1988, when glasnost resulted in it appearing alongside 1984. A year later We and Brave New World were published together in a combined edition. In 1994, the novel received a Prometheus Award in the "Hall of Fame" category.


Favorite High-Voltage BJT Power Trannies

I'm looking for suggestions for high-voltage bipolar power transistors you like, which might be suitable for use in amplifier circuits at modest currents. Successful candidates should have an fT of at least 30MHz, at currents of 0.5A, etc. Fairly-high capacitances are OK. Parts rated anywhere in the

Ingenious Geological Sleuthing Reveals the Shapes of Ancient Mountains | 80beats

Fiordland National Park
Fiordland National Park in New Zealand, the location of the study

What’s the News: Researchers have mapped out the detailed geological history of a 300-square-mile chunk of New Zealand, from 2.5 million years ago to the present day. The study showed how glaciers carved out the area’s distinctive valleys using a little-known technique called thermochronometry, which involves shooting proton beams onto rocks and making note of what happens—along with some impressive analytical skills.

How the Heck: Thermochronometry, as the name implies, is a way to measure both temperature and time. The general principle is that the deeper something is below the Earth’s surface, the warmer it is; thus, tracking a rock’s temperature over millions of years reveals how deep the rock was as it cooled.

This study used a particular version of the method called helium-4/helium-3 thermochronometry, first developed by a member of the research team in 2005. This technique lets you track the time and temperature for apatite, a mineral found in rocks like granite that solidify from liquid magma far beneath the surface. Two chemical elements in apatite—uranium and thorium—are radioactive. As they decay over millions of years, ...


Enraf 854ATG

I check the error code and found es 0407 and vendors claims that force transducer is faulty I want to know can this transducer is repairable ? because I don't see any damage or cause of failure. Is there any way that I can find the force transducer is faulty?or any method to check Force Transducer .

Has Birtherism Evolved? | The Intersection

Donald Trump isn’t stupid. And Donald Trump is a birther–at least of the “I have doubts” variety. Writes David Wiegel at Slate:

Trump—whose campaign may qualify as a massive, “I’m Still Here” publicity stunt—is responsible for the sudden acceptability of the question. On The View, he reminded viewers that he went to “the best schools,” so he knew that documents are forged all the time, and he didn’t trust what he’d heard about Obama. Even after Tuesday, when he finally released a scan of his 1946 birth certificate to ABC News, that claim hung in the air. It echoed what some birthers still say; it gave them wider uncritical media exposure than they’d gotten since Lou Dobbs left CNN.

One reason Trump has been able to do this is that two schools of birtherism have developed since 2008, and one of them has become a surprisingly comfortable place for conservatives to lounge. There have always been Orthodox Birthers. They start with the belief that Obama cannot be eligible for the presidency. They trust evidence they find online—an erroneous report about “Obama’s grandmother” saying he was born in Kenya, for example—which stays online forever, just like amateur diagnostic reports of how crashing planes couldn’t possibly have brought down the Twin Towers. If that evidence is challenged, they look to theories about what the founders thought “natural born citizenship” meant. Phil Berg, the attorney who filed the first birther lawsuits and who held a “March on Washington” in 2010, says Obama lost his citizenship because a school form from Indonesia calls him Indonesian. Another theory says Obama can’t be president because his father was Kenyan and that made his son a British citizen by default. (This theory would disqualify Trump, whose mother was Scottish.)

What Trump is embracing, and Corsi is selling, is Reform Birtherism. It’s deductive. “There’s something on that birth certificate that he doesn’t like,” said Trump last week. “I don’t know what is on the document,” said Corsi in 2009. The truth is unknowable, because Obama is hiding something about his birth documents.

I think it may be too rational to judge the two forms of birtherism as truly distinct. At bottom, both “start with a belief” and then come up with arguments to make the belief sound most plausible. From the outside, a new set of arguments may look like goalpost shifting–but to birthers, it will seem like nothing of the kind. Those new arguments will just further reinforce their preconceptions.

If anything, what I suspect is happening here is that smarter birthers like Trump–those more conversant with the respectable boundaries of mainstream political discourse–will tend to make more sophisticated arguments, and make them more convincingly. With birtherism–as is often the case–the more sophisticated arguments tend to be doubt mongering arguments.

But it’s still a belief system, just one with smoother, slicker advocates–not unlike the transition from young-Earth creationism to intelligent design.


Altitude Attitude Adjustment rev. 1

I formed the above title with this thought in mind: I've had people actually get angry over this subject. The attitude adjustment component can be solved, in most cases, by picking up a book, and by being WILLING to learn. However, for some, this is not as easy as it sounds, in my experience. Thank

2 Butt Weld Seams Comes Closer – Effects?

What will happen if 2 butt weld seams comes closer, Please specify details based on metallurgy and strength.

Client specification says weld toe to toe min 50 mm. Actually how much proximity minimum required?

If happen, to ensure soundness of welds any of the below can follow?

a)"NDT & Hardness te

Camcorder Advice

I'm looking at buying a camcorder but the choice is somewhat overwhelming so I'm hoping that some of you have some practical experience you might share.

I'm thinking of a compact digital type recording to flash memory. I'd like a decent sized CCD sensor & fair optical zoom, not concerned with d

‘Dal Futurismo all’Informale’ in Castelbasso

Attraverso l’arte del ’900 italiano: dal Futurismo all’Informale
Opere della Collezione De Donno

March 12 – May 8, 2011
Fondazione Malvina Menegaz, Castelbasso
Curated by Francesco Poli
Catalog

Il progetto espositivo, a cura di Francesco Poli e realizzato in collaborazione con l’Associazione Culturale Viaindustriae di Foligno, si propone come una narrazione chiara e corretta delle fasi fondamentali degli sviluppi dell’arte italiana del Novecento.

Questa mostra tratterà il primo periodo dell’arte del Novecento, che va dall’inizio del secolo fino alla svolta cruciale della fine degli anni ’50. attraverso le opere di Medardo Rosso, Umberto Boccioni, Giacomo Balla, Enrico Prampolini, Fortunato Depero, Giorgio de Chirico, Alberto Savinio, Ardengo Soffici, Mario Mafai (da aggiungere), Giorgio Morandi, Mario Sironi, Alberto Magnelli, Lucio Fontana, Alberto Burri, Emilio Vedova, Afro, Piero Manzoni.

In occasione della mostra la sezione didattica si presenta con una veste tutta nuova: il progetto “UNO, DU2, TR3, ..tocca a te!” propone visite guidate, percorsi educativi per le scuole ed eventi speciali.

Press release

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Video: Brake Installation and Maintenance

Do you want to learn how to upgrade your vehicle's brake system to something that's bigger and better with more stopping power? How about learning how to bleed your car's brakes or change your SUV's front brake pads? In this episode, Chris Duke provides step-by-step instructions in Motorz TV's B

Controlled Atmosphere For Coffee

When produccing coffee for expresso, we use controlled atmosphere to avoid oxidation. Usually Ar and N2 are recommended but we are thinking about using CO2. Apparently it could help in several ways: cost, better behaviTour to transport as it can be diluted inif there are changes of pressure and part

Trolling the Moon | Bad Astronomy

A long time ago, something really, really, really BIG hit the Moon. Hard. The explosion was huge beyond human grasp, and when it was all done, the hole it left on the Moon was 900 km (600 miles) across!

Behold, Mare Orientale:

This image was taken by the Lunar Reconnaissance Orbiter’s Wide Angle Camera, and shows the entire basin. It’s located just over the edge of the Moon as seen from Earth, so we can only get hints of it when we look from home. LRO can see it in all its neck-hair-raising glory.

See all those radial features emanating outward from it? Those are crater chains: secondary impact events as huge chunks of debris hundreds of meters or even kilometers across were thrown hundreds of kilometers away by the force of the impact!

Yegads. You can see these better in an interactive pan-and-scan image that allows you to zoom in to scales of 100 meters per pixel. It’s incredible.

But looking at the central part itself, I got a funny familiar feeling. I read reddit, after all. Was the Moon… trolling us?


SIVQ-aided laser capture microdissection: A tool for high-throughput expression profiling

Jason Hipp1, Jerome Cheng1, Jeffrey C. Hanson2, Wusheng Yan2, Phil Taylor3, Nan Hu2, Jaime
Rodriguez-Canales2, Jennifer Hipp2, Michael A. Tangrea2, Michael R. Emmert-Buck2, Ulysses Balis1

1Department of Pathology, University of Michigan School of Medicine, Division of Pathology Informatics, M4233 Med Sci I, 1301 Catherine, Ann Arbor, MI 48109-0602.

2National Institutes of Health, National Cancer Institute, Laboratory of Pathology, Center for Cancer Research, Advanced Technology Center, Room 109, 8717 Grovemont Circle, Gaithersburg, MD 20877.

3Division of Cancer Epidemiology and Genetics, Executive Plaza South, Room 7006, Rockville, MD 20892.

Abstract
Introduction: Laser capture microdissection (LCM) facilitates procurement of defined cell populations for study in the context of histopathology. The morphologic assessment step in the LCM procedure is time consuming and tedious, thus restricting the utility of the technology for large applications.

Results: Here, we describe the use of Spatially Invariant Vector Quantization (SIVQ) for histological analysis within LCM. Using SIVQ, we selected vectors as morphologic predicates that were representative of normal epithelial or cancer cells and then searched for phenotypically similar cells across entire tissue sections. The selected cells were subsequently auto-microdissected and the recovered RNA was analyzed by expression microarray. Gene expression profiles from SIVQ–LCM and standard LCM-derived samples demonstrated highly congruous signatures, confirming the equivalence of the differing microdissection methods.

Conclusion: SIVQ–LCM improves the workflow of microdissection in two significant ways. First, the process is transformative in that it shifts the pathologist’s role from technical execution of the entire microdissection to a limited-contact supervisory role, enabling large-scale extraction of tissue by expediting subsequent semi-autonomous identification of target cell populations. Second, this work-flow model provides an opportunity to systematically identify highly constrained cell populations and morphologically consistent regions within tissue sections. Integrating SIVQ with LCM in a single environment provides advanced capabilities for efficient and high-throughput histological-based molecular studies.


Key words: Laser capture microdissection, microarray, Spatially Invariant Vector Quantization

E-mail: *Ulysses J. Balis - ulysses@umich.edu
*Corresponding author
Received: 26 January 11 Accepted: 22 February 11 Published: 31 March 11
DOI: 10.4103/2153-3539.78500 J Pathol Inform 2011, 2:19
This article is available from: http://www.jpathinformatics.org/content/2/1/19
Copyright: © 2011 Hipp J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and
reproduction in any medium, provided the original author and source are credited.


This article may be cited as:
Hipp J, Cheng J, Hanson JC, Yan W, Taylor P, Hu N, Rodriguez-Canales J, Hipp J, Tangrea MA, Emmert-Buck MR, Balis U. SIVQ-aided laser capture microdissection: A tool for high-throughput
expression profiling. J Pathol Inform 2011;2:19

 

Twofer for Far Leftist Artists: Hatred for Jesus and Sarah Palin

From Eric Dondero:

An "Art" Show opened at the R&R Gallery in Los Angeles on January 28.

The Exhibit shows out of the mainstream depictions of Jesus Christ.

From the description on therandr website:

The R&R Gallery is celebrating it's very first trip around the sun with a salute to The Man. That's right, we're pulling out the big guns...it's The JESUS SHOW. Whether you're a believer or an unrepentant sinner, come out and give props to the O.G. Badass. We may not be turning water into wine, but we'll be trying our damndest, with original works by some of the finest of God's children. Holy Shit.

Editor's comment - As offensive as this is, as libertarians, we of course, fully support their right to create such works. But it does leave one to wonder what the outcry would be like if Obama was similarly depicted as Muhammed.

photo h/t Hoft